-- dump date 20140619_085811 -- class Genbank::Feature -- table feature -- table main -- field 1 id -- field 2 type -- field 3 name -- field 4 contig -- field 5 start_pos -- field 6 end_pos -- field 7 strand -- field 8 description -- field 9 chrom_position -- field 10 organism -- field 11 GeneID -- header -- id type name contig start_pos end_pos strand description chrom_position organism GeneID 155864000001 SEQ_END SEQ_END NC_002655.2 5528445 5528445 DR NC_002655.2; contig end 5528445..5528445 Escherichia coli O157:H7 str. EDL933 155864000002 SEQ_END SEQ_END NC_007414.1 92077 92077 DR NC_007414.1; contig end 92077..92077 Escherichia coli O157:H7 str. EDL933 NP_285693.1 CDS thrL NC_002655.2 190 273 D involved in threonine biosynthesis; controls the expression of the thrLABC operon; thr operon leader peptide 190..273 Escherichia coli O157:H7 str. EDL933 962112 NP_285694.1 CDS thrA NC_002655.2 354 2816 D multifunctional homotetrameric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways; bifunctional aspartokinase I/homoserine dehydrogenase I 354..2816 Escherichia coli O157:H7 str. EDL933 962110 NP_285695.1 CDS thrB NC_002655.2 2818 3750 D catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase 2818..3750 Escherichia coli O157:H7 str. EDL933 962111 NP_285696.1 CDS thrC NC_002655.2 3751 5037 D catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase 3751..5037 Escherichia coli O157:H7 str. EDL933 956660 NP_285697.1 CDS Z0005 NC_002655.2 5251 5547 D hypothetical protein 5251..5547 Escherichia coli O157:H7 str. EDL933 956661 NP_285698.1 CDS yaaA NC_002655.2 5700 6476 R hypothetical protein complement(5700..6476) Escherichia coli O157:H7 str. EDL933 956662 NP_285699.1 CDS yaaJ NC_002655.2 6546 7976 R inner membrane transport protein complement(6546..7976) Escherichia coli O157:H7 str. EDL933 956663 NP_285700.1 CDS talB NC_002655.2 8255 9208 D Maintains the balance of metabolites in the pentose-phosphate pathway; transaldolase B 8255..9208 Escherichia coli O157:H7 str. EDL933 956664 NP_285701.1 CDS mogA NC_002655.2 9323 9910 D forms a trimer; related to eukaryotic protein gephyrin; functions during molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MogA 9323..9910 Escherichia coli O157:H7 str. EDL933 956666 NP_285702.1 CDS yaaH NC_002655.2 9945 10511 R hypothetical protein complement(9945..10511) Escherichia coli O157:H7 str. EDL933 956668 NP_285703.1 CDS Z0011 NC_002655.2 10660 11373 R hypothetical protein complement(10660..11373) Escherichia coli O157:H7 str. EDL933 956669 NP_285705.1 CDS yaaI NC_002655.2 11399 11803 R hypothetical protein complement(11399..11803) Escherichia coli O157:H7 str. EDL933 956671 NP_285706.1 CDS dnaK NC_002655.2 12180 14096 D heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 12180..14096 Escherichia coli O157:H7 str. EDL933 956673 NP_285707.1 CDS dnaJ NC_002655.2 14185 15315 D chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; molecular chaperone DnaJ 14185..15315 Escherichia coli O157:H7 str. EDL933 956674 NP_285708.1 CDS gef NC_002655.2 15419 15628 R Gef protein complement(15419..15628) Escherichia coli O157:H7 str. EDL933 956675 NP_285709.1 CDS nhaA NC_002655.2 16157 17323 D exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH; pH-dependent sodium/proton antiporter 16157..17323 Escherichia coli O157:H7 str. EDL933 956676 NP_285710.1 CDS nhaR NC_002655.2 17383 18288 D Na+/H+ antiporter regulatory protein; activates the genes nhaA and osmC; transcriptional activator NhaR 17383..18288 Escherichia coli O157:H7 str. EDL933 956677 NP_285711.1 CDS Z0020 NC_002655.2 18326 18949 R No significant matches; hypothetical protein complement(18326..18949) Escherichia coli O157:H7 str. EDL933 956678 NP_285712.1 CDS Z0021 NC_002655.2 18960 19286 R No significant matches; hypothetical protein complement(18960..19286) Escherichia coli O157:H7 str. EDL933 956679 NP_285713.1 CDS Z0022 NC_002655.2 19299 21749 R usher protein complement(19299..21749) Escherichia coli O157:H7 str. EDL933 956680 NP_285714.1 CDS Z0023 NC_002655.2 21762 22445 R chaperone protein complement(21762..22445) Escherichia coli O157:H7 str. EDL933 956681 NP_285715.1 CDS Z0024 NC_002655.2 22495 23028 R type-1 fimbrial protein complement(22495..23028) Escherichia coli O157:H7 str. EDL933 956683 NP_285716.1 CDS Z0025 NC_002655.2 23330 24751 R No significant matches; hypothetical protein complement(23330..24751) Escherichia coli O157:H7 str. EDL933 956684 NP_285717.1 CDS rpsT NC_002655.2 25221 25484 R binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 complement(25221..25484) Escherichia coli O157:H7 str. EDL933 956688 NP_285718.1 CDS Z0028 NC_002655.2 25587 25811 D hypothetical protein 25587..25811 Escherichia coli O157:H7 str. EDL933 956689 NP_285719.1 CDS ribF NC_002655.2 25819 26760 D catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase 25819..26760 Escherichia coli O157:H7 str. EDL933 956690 NP_285720.1 CDS ileS NC_002655.2 26803 29619 D IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase type 1 subfamily; some organisms carry two different copies of this enzyme; isoleucyl-tRNA synthetase 26803..29619 Escherichia coli O157:H7 str. EDL933 956691 NP_285721.1 CDS lspA NC_002655.2 29619 30113 D lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 29619..30113 Escherichia coli O157:H7 str. EDL933 956692 NP_285722.1 CDS slpA NC_002655.2 30201 30650 D peptidyl-prolyl cis- trans isomerase 30201..30650 Escherichia coli O157:H7 str. EDL933 956693 NP_285723.1 CDS ispH NC_002655.2 30652 31602 D catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 30652..31602 Escherichia coli O157:H7 str. EDL933 956694 NP_285724.1 CDS yaaF NC_002655.2 31668 32582 D catalyzes the hydrolysis of both purine and pyrimidine ribonucleosides; ribonucleoside hydrolase RihC 31668..32582 Escherichia coli O157:H7 str. EDL933 956696 NP_285725.1 CDS dapB NC_002655.2 32749 33570 D catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase 32749..33570 Escherichia coli O157:H7 str. EDL933 956697 NP_285726.1 CDS carA NC_002655.2 34026 35174 D catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit 34026..35174 Escherichia coli O157:H7 str. EDL933 956698 NP_285727.1 CDS carB NC_002655.2 35192 38413 D four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit 35192..38413 Escherichia coli O157:H7 str. EDL933 956699 NP_285728.1 CDS Z0039 NC_002655.2 38421 38639 R No significant matches; hypothetical protein complement(38421..38639) Escherichia coli O157:H7 str. EDL933 956700 NP_285729.2 CDS Z0040 NC_002655.2 38674 39069 D regulator of carnitine metabolism; induces the caiTABCDE and fixABCX operons; DNA-binding transcriptional activator CaiF 38674..39069 Escherichia coli O157:H7 str. EDL933 956701 NP_285730.1 CDS caiE NC_002655.2 39188 39799 R involved in the synthesis of a cofactor required for carnitine dehydratase and carnitine racemase activities; carnitine operon protein CaiE complement(39188..39799) Escherichia coli O157:H7 str. EDL933 956703 NP_285731.2 CDS caiD NC_002655.2 39784 40569 R catalyzes the dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA; carnitinyl-CoA dehydratase complement(39784..40569) Escherichia coli O157:H7 str. EDL933 956704 NP_285732.1 CDS caiC NC_002655.2 40678 42246 R crotonobetaine/carnitine-CoA ligase complement(40678..42246) Escherichia coli O157:H7 str. EDL933 956705 NP_285733.1 CDS caiB NC_002655.2 42305 43522 R catalyzes formation of L-carnitinyl-CoA by transfering the CoA moiety from gamma-butyrobetainyl-CoA, also catalyzes the formation of crotonobetainyl-CoA by transfer of CoA from gamma-butyrobetainyl-CoA or L-carnitinyl-CoA to crotonobetaine; crotonobetainyl-CoA:carnitine CoA-transferase complement(42305..43522) Escherichia coli O157:H7 str. EDL933 956706 NP_285734.1 CDS caiA NC_002655.2 43651 44793 R catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA; crotonobetainyl-CoA dehydrogenase complement(43651..44793) Escherichia coli O157:H7 str. EDL933 956708 NP_285735.1 CDS caiT NC_002655.2 44824 46338 R catalyzes the exchange of L-carnitine for gamma-butyrobetaine in carnitine metabolism; L-carnitine/gamma-butyrobetaine antiporter complement(44824..46338) Escherichia coli O157:H7 str. EDL933 956709 NP_285736.2 CDS fixA NC_002655.2 46817 47587 D required for anaerobic carnitine reduction, may act to transfer electrons to crotonobetaine reductase; electron transfer flavoprotein FixA 46817..47587 Escherichia coli O157:H7 str. EDL933 956710 NP_285737.1 CDS fixB NC_002655.2 47602 48543 D involved in electron transfer during carnitine metabolism; electron transfer flavoprotein FixB 47602..48543 Escherichia coli O157:H7 str. EDL933 956711 NP_285738.1 CDS fixC NC_002655.2 48594 49880 D FAD/NAD(P)-binding domain; possibly part of an electron transfer system required for anaerobic carnitine reduction; oxidoreductase FixC 48594..49880 Escherichia coli O157:H7 str. EDL933 956714 NP_285739.1 CDS fixX NC_002655.2 49877 50164 D ferredoxin 49877..50164 Escherichia coli O157:H7 str. EDL933 956715 NP_285740.1 CDS yaaU NC_002655.2 50222 51553 D transporter 50222..51553 Escherichia coli O157:H7 str. EDL933 956716 NP_285741.1 CDS yabF NC_002655.2 51661 52191 D Required for full activity of KefC, a potassium-proton antiporter; glutathione-regulated potassium-efflux system ancillary protein KefF 51661..52191 Escherichia coli O157:H7 str. EDL933 956717 NP_285742.1 CDS kefC NC_002655.2 52184 54046 D transport system that facilitates potassium-efflux; glutathione-regulated potassium-efflux system protein KefC 52184..54046 Escherichia coli O157:H7 str. EDL933 956719 NP_285743.1 CDS folA NC_002655.2 54238 54717 D catalyzes the reduction of dihydrofolate to tetrahydrofolate; dihydrofolate reductase 54238..54717 Escherichia coli O157:H7 str. EDL933 956721 NP_285744.1 CDS Z0056 NC_002655.2 54803 55036 D antitoxin of gyrase inhibiting toxin-antitoxin system 54803..55036 Escherichia coli O157:H7 str. EDL933 956723 NP_285745.1 CDS Z0057 NC_002655.2 55039 55353 D toxin of gyrase inhibiting toxin-antitoxin system 55039..55353 Escherichia coli O157:H7 str. EDL933 956724 NP_285746.1 CDS apaH NC_002655.2 55350 56198 R hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP; diadenosine tetraphosphatase complement(55350..56198) Escherichia coli O157:H7 str. EDL933 956725 NP_285747.1 CDS apaG NC_002655.2 56205 56582 R protein associated with Co2+ and Mg2+ efflux; ApaG protein complement(56205..56582) Escherichia coli O157:H7 str. EDL933 956726 NP_285748.1 CDS ksgA NC_002655.2 56585 57406 R catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase complement(56585..57406) Escherichia coli O157:H7 str. EDL933 956727 NP_285749.1 CDS pdxA NC_002655.2 57403 58392 R catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate); 4-hydroxythreonine-4-phosphate dehydrogenase complement(57403..58392) Escherichia coli O157:H7 str. EDL933 956728 NP_285750.1 CDS surA NC_002655.2 58392 59678 R Chaperone involved in the folding of extracytoplasmic proteins, especially OmpA, OmpF and LamB; peptidyl-prolyl cis-trans isomerase SurA complement(58392..59678) Escherichia coli O157:H7 str. EDL933 956729 NP_285751.1 CDS imp NC_002655.2 59731 62085 R determines N-hexane tolerance and is involved in outer membrane permeability; organic solvent tolerance protein complement(59731..62085) Escherichia coli O157:H7 str. EDL933 956730 NP_285752.1 CDS djlA NC_002655.2 62340 63155 D functions as a co-chaperone with DnaK; involved in regulation of colanic acid capsule; inner membrane protein; dimerized via transmembrane domain; J-like domain is cytoplasmic and can functionally substitute for DnaJ; stimulates synthesis of colanic acid mucoid capsule through the RcsB/C signal transduction system; molecular chaperone DnaJ 62340..63155 Escherichia coli O157:H7 str. EDL933 956731 NP_285753.1 CDS Z0065 NC_002655.2 63450 64202 D hypothetical protein 63450..64202 Escherichia coli O157:H7 str. EDL933 956733 NP_285754.1 CDS yabO NC_002655.2 64620 65279 R catalyzes the synthesis of pseudouridine from uracil-746 in 23S ribosomal RNA and from uracil-32 in the anticodon stem and loop of transfer RNAs; 23S rRNA/tRNA pseudouridine synthase A complement(64620..65279) Escherichia coli O157:H7 str. EDL933 956734 NP_285755.1 CDS Z0067 NC_002655.2 65291 68197 R transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA; ATP-dependent helicase HepA complement(65291..68197) Escherichia coli O157:H7 str. EDL933 956735 NP_285756.1 CDS polB NC_002655.2 68361 70712 R Has polymerase, DNA-binding and 3'-5' exonuclease activities. In Aeropyrum pernix this protein is sensitive to aphidicolin and stable at 95#C; DNA polymerase II complement(68361..70712) Escherichia coli O157:H7 str. EDL933 956736 NP_285757.1 CDS araD NC_002655.2 70787 71482 R catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; L-ribulose-5-phosphate 4-epimerase complement(70787..71482) Escherichia coli O157:H7 str. EDL933 956737 NP_285758.1 CDS araA NC_002655.2 71682 73184 R catalyzes the formation of L-ribulose from L-arabinose in L-arabinose catabolism; L-arabinose isomerase complement(71682..73184) Escherichia coli O157:H7 str. EDL933 956742 NP_285759.1 CDS araB NC_002655.2 73195 74895 R catalyzes the phosphorylation of ribulose to ribulose 5-phosphate; ribulokinase complement(73195..74895) Escherichia coli O157:H7 str. EDL933 956743 NP_285760.1 CDS araC NC_002655.2 75234 76112 D positive and negative regulator; regulates the araBAD and araFGH operons and other genes involved in the transport and catabolism of L-arabinose; DNA-binding transcriptional regulator AraC 75234..76112 Escherichia coli O157:H7 str. EDL933 956744 NP_285761.1 CDS yabI NC_002655.2 76198 76962 D hypothetical protein 76198..76962 Escherichia coli O157:H7 str. EDL933 956745 NP_285762.1 CDS thiQ NC_002655.2 77049 77747 R with TbpA and ThiP is part of the thiamine and TPP transport system; thiamine transporter ATP-binding subunit complement(77049..77747) Escherichia coli O157:H7 str. EDL933 956746 NP_285763.1 CDS thiP NC_002655.2 77731 79341 R permease; with TbpA and ThiQ functions in transport of thiamine and thiamine pyrophosphate into the cell; repressed in presence of exogenous thiamine; thiamine transporter membrane protein complement(77731..79341) Escherichia coli O157:H7 str. EDL933 956747 NP_285764.1 CDS tbpA NC_002655.2 79317 80300 R part of the thiamine and TPP transport system tbpA-thiPQ; thiamine transporter substrate binding subunit complement(79317..80300) Escherichia coli O157:H7 str. EDL933 956748 NP_285765.1 CDS Z0078 NC_002655.2 80672 81241 D hypothetical protein 80672..81241 Escherichia coli O157:H7 str. EDL933 956752 NP_285766.1 CDS yabN NC_002655.2 81470 83128 R activates sgrS under glucose-phosphate stress conditions; transcriptional regulator SgrR complement(81470..83128) Escherichia coli O157:H7 str. EDL933 956753 NP_285767.1 CDS leuD NC_002655.2 83456 84061 R catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D; isopropylmalate isomerase small subunit complement(83456..84061) Escherichia coli O157:H7 str. EDL933 956754 NP_285768.1 CDS leuC NC_002655.2 84072 85472 R dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; isopropylmalate isomerase large subunit complement(84072..85472) Escherichia coli O157:H7 str. EDL933 956755 NP_285769.2 CDS leuB NC_002655.2 85475 86566 R catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis; 3-isopropylmalate dehydrogenase complement(85475..86566) Escherichia coli O157:H7 str. EDL933 956756 NP_285770.1 CDS leuA NC_002655.2 86566 88137 R catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis; 2-isopropylmalate synthase complement(86566..88137) Escherichia coli O157:H7 str. EDL933 956757 NP_285771.1 CDS leuL NC_002655.2 88230 88316 R involved in attenuation control of the leuABCD operon in leucine biosynthesis; leu operon leader peptide complement(88230..88316) Escherichia coli O157:H7 str. EDL933 956758 NP_285772.1 CDS leuO NC_002655.2 88956 89918 D activator for leuABCD operon; member of LysR family of transcriptional activators; leucine transcriptional activator 88956..89918 Escherichia coli O157:H7 str. EDL933 956759 NP_285773.2 CDS ilvI NC_002655.2 90236 91960 D catalyzes the formation of 2-acetolactate from pyruvate, leucine sensitive; acetolactate synthase 3 catalytic subunit 90236..91960 Escherichia coli O157:H7 str. EDL933 956760 NP_285774.1 CDS ilvH NC_002655.2 91963 92454 D with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; acetolactate synthase 3 regulatory subunit 91963..92454 Escherichia coli O157:H7 str. EDL933 956761 NP_285776.1 CDS fruR NC_002655.2 92634 93638 D binds D-fructose as an inducer; involved in regulation of operons for central pathways of carbon metabolism; DNA-binding transcriptional regulator FruR 92634..93638 Escherichia coli O157:H7 str. EDL933 956764 NP_285777.1 CDS yabB NC_002655.2 94240 94698 D MraZ; UPF0040; crystal structure shows similarity to AbrB; cell division protein MraZ 94240..94698 Escherichia coli O157:H7 str. EDL933 956765 NP_285778.1 CDS mraW NC_002655.2 94700 95641 D S-adenosyl-methyltransferase MraW 94700..95641 Escherichia coli O157:H7 str. EDL933 956766 NP_285779.1 CDS ftsL NC_002655.2 95638 96003 D membrane bound cell division protein at septum containing leucine zipper motif; cell division protein FtsL 95638..96003 Escherichia coli O157:H7 str. EDL933 956768 NP_285780.1 CDS ftsI NC_002655.2 96019 97785 D septum formation; penicillin-binding protein 3; peptidoglycan synthetase 96019..97785 Escherichia coli O157:H7 str. EDL933 956770 NP_285781.1 CDS murE NC_002655.2 97772 99259 D involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 97772..99259 Escherichia coli O157:H7 str. EDL933 956771 NP_285782.1 CDS murF NC_002655.2 99256 100614 D UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase 99256..100614 Escherichia coli O157:H7 str. EDL933 956772 NP_285783.1 CDS mraY NC_002655.2 100608 101690 D First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 100608..101690 Escherichia coli O157:H7 str. EDL933 956773 NP_285784.1 CDS murD NC_002655.2 101693 103009 D UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 101693..103009 Escherichia coli O157:H7 str. EDL933 956774 NP_285785.1 CDS ftsW NC_002655.2 103009 104253 D integral membrane protein involved in stabilizing FstZ ring during cell division; cell division protein FtsW 103009..104253 Escherichia coli O157:H7 str. EDL933 956775 NP_285786.1 CDS murG NC_002655.2 104250 105317 D UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase 104250..105317 Escherichia coli O157:H7 str. EDL933 956776 NP_285787.1 CDS murC NC_002655.2 105371 106846 D Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase 105371..106846 Escherichia coli O157:H7 str. EDL933 956777 NP_285788.1 CDS ddl NC_002655.2 106839 107759 D D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanine--D-alanine ligase 106839..107759 Escherichia coli O157:H7 str. EDL933 956778 NP_285789.1 CDS ftsQ NC_002655.2 107761 108591 D involved in septum formation; cell division protein FtsQ 107761..108591 Escherichia coli O157:H7 str. EDL933 956781 NP_285790.1 CDS ftsA NC_002655.2 108588 109850 D ATP-binding involved in recruitment of FtsK to Z ring; essential cell division protein; colocalizes with FtsZ through direct interaction to the septal ring structure; structurally similar to eukaryotic actin; binds directly to the cell membrane; cell division protein FtsA 108588..109850 Escherichia coli O157:H7 str. EDL933 956782 NP_285791.1 CDS ftsZ NC_002655.2 109911 111062 D GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ 109911..111062 Escherichia coli O157:H7 str. EDL933 956784 NP_285792.1 CDS lpxC NC_002655.2 111163 112080 D zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase 111163..112080 Escherichia coli O157:H7 str. EDL933 956787 NP_285793.2 CDS yacA NC_002655.2 112311 112823 D secM translational pause allows for the initiation of secA translation; SecA regulator SecM 112311..112823 Escherichia coli O157:H7 str. EDL933 956788 NP_285794.1 CDS secA NC_002655.2 112885 115590 D functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 112885..115590 Escherichia coli O157:H7 str. EDL933 956789 NP_285795.1 CDS mutT NC_002655.2 115650 116048 D nucleoside triphosphate pyrophosphohydrolase 115650..116048 Escherichia coli O157:H7 str. EDL933 956790 NP_285796.1 CDS Z0110 NC_002655.2 116054 116188 R hypothetical protein complement(116054..116188) Escherichia coli O157:H7 str. EDL933 956791 NP_285797.1 CDS yacG NC_002655.2 116139 116336 R zinc-binding protein complement(116139..116336) Escherichia coli O157:H7 str. EDL933 956792 NP_285798.1 CDS yacF NC_002655.2 116346 117089 R hypothetical protein complement(116346..117089) Escherichia coli O157:H7 str. EDL933 956793 NP_285799.1 CDS coaE NC_002655.2 117089 117709 R catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; dephospho-CoA kinase complement(117089..117709) Escherichia coli O157:H7 str. EDL933 956794 NP_285800.1 CDS guaC NC_002655.2 117934 118977 D catalyzes the NADPH-dependent deamination of GMP to inosine monophosphate; guanosine 5'-monophosphate oxidoreductase 117934..118977 Escherichia coli O157:H7 str. EDL933 956795 NP_285801.1 CDS Z0115 NC_002655.2 118897 119004 R hypothetical protein complement(118897..119004) Escherichia coli O157:H7 str. EDL933 956796 NP_285802.1 CDS hofC NC_002655.2 119012 120214 R type IV pilin biogenesis protein complement(119012..120214) Escherichia coli O157:H7 str. EDL933 956797 NP_285803.1 CDS hofB NC_002655.2 120204 121589 R hypothetical protein complement(120204..121589) Escherichia coli O157:H7 str. EDL933 956799 NP_285804.1 CDS ppdD NC_002655.2 121599 122039 R major pilin subunit complement(121599..122039) Escherichia coli O157:H7 str. EDL933 956800 NP_285805.1 CDS nadC NC_002655.2 122242 123135 R catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide; quinolinate phosphoribosyltransferase complement(122242..123135) Escherichia coli O157:H7 str. EDL933 956801 NP_285806.1 CDS ampD NC_002655.2 123223 123774 D N-acetyl-anhydromuranmyl-L-alanine amidase 123223..123774 Escherichia coli O157:H7 str. EDL933 956802 NP_285807.1 CDS ampE NC_002655.2 123771 124625 D involved in regulation of beta-lactamase; signaling protein; regulatory protein AmpE 123771..124625 Escherichia coli O157:H7 str. EDL933 956804 NP_285808.1 CDS aroP NC_002655.2 124668 126041 R aromatic amino acid transporter complement(124668..126041) Escherichia coli O157:H7 str. EDL933 956805 NP_285809.1 CDS pdhR NC_002655.2 126582 127346 D activates lctPRD operon; autoregulates itself through repression of pdhR-aceEF-lpdA operon; regulates pyruvate dehydrogenase complex; transcriptional regulator PdhR 126582..127346 Escherichia coli O157:H7 str. EDL933 956808 NP_285810.1 CDS aceE NC_002655.2 127507 130170 D E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC; pyruvate dehydrogenase subunit E1 127507..130170 Escherichia coli O157:H7 str. EDL933 956809 NP_285811.1 CDS aceF NC_002655.2 130185 132077 D E2 component of pyruvate dehydrogenase multienzyme complex; in Escherichia coli AceF contains three N-terminal lipoyl domains; dihydrolipoamide acetyltransferase 130185..132077 Escherichia coli O157:H7 str. EDL933 956812 NP_285812.1 CDS lpdA NC_002655.2 132285 133709 D E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; dihydrolipoamide dehydrogenase 132285..133709 Escherichia coli O157:H7 str. EDL933 956813 NP_285813.1 CDS yacH NC_002655.2 133780 135633 R hypothetical protein complement(133780..135633) Escherichia coli O157:H7 str. EDL933 956814 NP_285814.1 CDS acnB NC_002655.2 135988 138585 D catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate; bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase 135988..138585 Escherichia coli O157:H7 str. EDL933 956815 NP_285815.2 CDS yacL NC_002655.2 138761 139123 D hypothetical protein 138761..139123 Escherichia coli O157:H7 str. EDL933 956816 NP_285816.1 CDS speD NC_002655.2 139161 139955 R S-adenosylmethionine provides the aminopropyl moiety required for spermidine biosynthesis from putrescine; S-adenosylmethionine decarboxylase complement(139161..139955) Escherichia coli O157:H7 str. EDL933 956820 NP_285817.1 CDS speE NC_002655.2 139971 140837 R catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine; spermidine synthase complement(139971..140837) Escherichia coli O157:H7 str. EDL933 956821 NP_285818.1 CDS yacC NC_002655.2 140943 141413 R hypothetical protein complement(140943..141413) Escherichia coli O157:H7 str. EDL933 956822 NP_285819.1 CDS yacK NC_002655.2 141456 143006 D laccase; copper-stimulated phenoloxidase and ferroxidase which may be involved in copper detoxification; multicopper oxidase 141456..143006 Escherichia coli O157:H7 str. EDL933 956823 NP_285820.1 CDS gcd NC_002655.2 143208 145598 R glucose dehydrogenase complement(143208..145598) Escherichia coli O157:H7 str. EDL933 956827 NP_285821.2 CDS hpt NC_002655.2 145804 146340 D Catalyzes the salvage synthesis of inosine-5'-monophosphate (IMP) and guanosine-5'-monophosphate (GMP) from the purine bases hypoxanthine and guanine, respectively; hypoxanthine-guanine phosphoribosyltransferase 145804..146340 Escherichia coli O157:H7 str. EDL933 956828 NP_285822.1 CDS yadF NC_002655.2 146381 147043 R catalyzes the interconversion of bicarbonate and carbon dioxide; carbonic anhydrase complement(146381..147043) Escherichia coli O157:H7 str. EDL933 956830 NP_285823.1 CDS yadG NC_002655.2 147152 148078 D ABC transporter ATP-binding protein 147152..148078 Escherichia coli O157:H7 str. EDL933 956832 NP_285824.1 CDS yadH NC_002655.2 148075 148845 D hypothetical protein 148075..148845 Escherichia coli O157:H7 str. EDL933 956833 NP_285825.1 CDS yadI NC_002655.2 148950 149390 D PTS enzyme II B component 148950..149390 Escherichia coli O157:H7 str. EDL933 956834 NP_285826.1 CDS yadE NC_002655.2 149454 150683 D hypothetical protein 149454..150683 Escherichia coli O157:H7 str. EDL933 956835 NP_285827.1 CDS panD NC_002655.2 150687 151067 R Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5); aspartate alpha-decarboxylase complement(150687..151067) Escherichia coli O157:H7 str. EDL933 956836 NP_285828.1 CDS yadD NC_002655.2 151341 152237 D hypothetical protein 151341..152237 Escherichia coli O157:H7 str. EDL933 956837 NP_285829.1 CDS panC NC_002655.2 152536 153387 R catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine; pantoate--beta-alanine ligase complement(152536..153387) Escherichia coli O157:H7 str. EDL933 956839 NP_285830.1 CDS panB NC_002655.2 153399 154193 R catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate; 3-methyl-2-oxobutanoate hydroxymethyltransferase complement(153399..154193) Escherichia coli O157:H7 str. EDL933 956841 NP_285831.1 CDS yadC NC_002655.2 154328 155437 R fimbrial protein complement(154328..155437) Escherichia coli O157:H7 str. EDL933 956842 NP_285832.1 CDS yadK NC_002655.2 155449 156039 R fimbrial protein complement(155449..156039) Escherichia coli O157:H7 str. EDL933 956843 NP_285833.1 CDS yadL NC_002655.2 156060 156665 R fimbrial protein complement(156060..156665) Escherichia coli O157:H7 str. EDL933 956844 NP_285834.1 CDS yadM NC_002655.2 156680 157240 R fimbrial protein complement(156680..157240) Escherichia coli O157:H7 str. EDL933 956845 NP_285835.2 CDS htrE NC_002655.2 157242 159842 R similar to the fimbrial usher protein PapC; outer membrane usher protein complement(157242..159842) Escherichia coli O157:H7 str. EDL933 956847 NP_285836.1 CDS ecpD NC_002655.2 159884 160615 R chaperone protein EcpD complement(159884..160615) Escherichia coli O157:H7 str. EDL933 956849 NP_285837.1 CDS yadN NC_002655.2 160696 161301 R fimbrial protein complement(160696..161301) Escherichia coli O157:H7 str. EDL933 956850 NP_285838.1 CDS folK NC_002655.2 161573 162055 R catalyzes the formation of 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine and ATP; 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase complement(161573..162055) Escherichia coli O157:H7 str. EDL933 956852 NP_285839.2 CDS pcnB NC_002655.2 162052 163470 R Polymerase that creates the 3' poly(A) tail found in some mRNA's; poly(A) polymerase complement(162052..163470) Escherichia coli O157:H7 str. EDL933 956853 NP_285840.2 CDS yadB NC_002655.2 163509 164405 R this tRNA synthetase lacks the tRNA anticodon interaction domain; instead this enzyme modifies tRNA(Asp) with glutamate by esterifying glutamate to the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of queosine generating a modified nucleoside at the first anticodon position of tRNAAsp; the modified tRNA does not bind elongation factor Tu; glutamyl-Q tRNA(Asp) synthetase complement(163509..164405) Escherichia coli O157:H7 str. EDL933 956855 NP_285841.1 CDS dksA NC_002655.2 164472 164927 R RNA polymerase-binding transcription factor complement(164472..164927) Escherichia coli O157:H7 str. EDL933 956857 NP_285842.1 CDS sfsA NC_002655.2 165105 165809 R Regulatory factor involved in maltose metabolism; sugar fermentation stimulation protein A complement(165105..165809) Escherichia coli O157:H7 str. EDL933 956859 NP_285843.1 CDS yadP NC_002655.2 165824 166363 R 2'-5' RNA ligase complement(165824..166363) Escherichia coli O157:H7 str. EDL933 956861 NP_285844.1 CDS hrpB NC_002655.2 166383 168857 D similar in sequence to the ATP-dependent RNA helicase HrpA; ATP-dependent RNA helicase HrpB 166383..168857 Escherichia coli O157:H7 str. EDL933 956862 NP_285845.1 CDS mrcB NC_002655.2 169053 171587 D bifunctional periplasmic enzyme; contains transglycosylase and transpeptidase activity; major enzyme for peptidoglycan biosynthesis in Escherichia coli; transmembrane protein; forms dimers; three variants, one of which may be a degradation product, while the other appears to result from an alternative initiation site, are found within the cell; penicillin-binding protein 1b 169053..171587 Escherichia coli O157:H7 str. EDL933 956863 NP_285846.1 CDS fhuA NC_002655.2 171807 174050 D involved with the transport of ferrichrome across the outer membrane; binds the ferrichrome-iron ligand and interacts with the TonB protein; ferrichrome outer membrane transporter 171807..174050 Escherichia coli O157:H7 str. EDL933 956865 NP_285847.1 CDS fhuC NC_002655.2 174101 174898 D part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter; iron-hydroxamate transporter ATP-binding subunit 174101..174898 Escherichia coli O157:H7 str. EDL933 956866 NP_285848.1 CDS fhuD NC_002655.2 174898 175788 D Part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter; binds to all hydroxamate siderophores; iron-hydroxamate transporter substrate-binding subunit 174898..175788 Escherichia coli O157:H7 str. EDL933 956867 NP_285849.1 CDS fhuB NC_002655.2 175785 177767 D part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter involved in the high-affinity transport of Fe(3+)-ferrichrome; iron-hydroxamate transporter permease subunit 175785..177767 Escherichia coli O157:H7 str. EDL933 956868 NP_285850.1 CDS hemL NC_002655.2 177802 179082 R Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway; glutamate-1-semialdehyde aminotransferase complement(177802..179082) Escherichia coli O157:H7 str. EDL933 956871 NP_285851.1 CDS yadQ NC_002655.2 179307 180728 D Acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation; chloride channel protein 179307..180728 Escherichia coli O157:H7 str. EDL933 956872 NP_285852.1 CDS yadR NC_002655.2 180810 181154 D essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors; iron-sulfur cluster insertion protein ErpA 180810..181154 Escherichia coli O157:H7 str. EDL933 956873 NP_285853.1 CDS yadS NC_002655.2 181201 181824 R hypothetical protein complement(181201..181824) Escherichia coli O157:H7 str. EDL933 956874 NP_285854.1 CDS yadT NC_002655.2 181862 182662 R solute binding component of the vitamin B12 transport system BtuCDF; vitamin B12-transporter protein BtuF complement(181862..182662) Escherichia coli O157:H7 str. EDL933 956876 NP_285855.1 CDS pfs NC_002655.2 182655 183353 R enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase complement(182655..183353) Escherichia coli O157:H7 str. EDL933 956877 NP_285856.1 CDS dgt NC_002655.2 183437 184954 D forms a homotetramer; requires magnesium for activity; catalyzes the hydrolysis of dGTP to form deoxyguanosine and triphosphate; deoxyguanosinetriphosphate triphosphohydrolase 183437..184954 Escherichia coli O157:H7 str. EDL933 956878 NP_285857.1 CDS htrA NC_002655.2 185084 186508 D protease Do; required at high temperature; degrades damaged proteins; serine endoprotease 185084..186508 Escherichia coli O157:H7 str. EDL933 956879 NP_285858.2 CDS yaeG NC_002655.2 186663 187820 D regulates the expression of the operons for the enzymes involved in galactarate, glucarate and glycerate utilization; carbohydrate diacid transcriptional activator CdaR 186663..187820 Escherichia coli O157:H7 str. EDL933 956880 NP_285859.1 CDS yaeH NC_002655.2 187909 188295 R hypothetical protein complement(187909..188295) Escherichia coli O157:H7 str. EDL933 956884 NP_285860.1 CDS dapD NC_002655.2 188610 189434 R catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway; 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase complement(188610..189434) Escherichia coli O157:H7 str. EDL933 956888 NP_285861.1 CDS glnD NC_002655.2 189465 192137 R catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein; PII uridylyl-transferase complement(189465..192137) Escherichia coli O157:H7 str. EDL933 956891 NP_285862.1 CDS map NC_002655.2 192199 192993 R catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn; methionine aminopeptidase complement(192199..192993) Escherichia coli O157:H7 str. EDL933 956892 NP_285863.1 CDS rpsB NC_002655.2 193361 194086 D one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 193361..194086 Escherichia coli O157:H7 str. EDL933 956893 NP_285864.1 CDS tsf NC_002655.2 194344 195195 D EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 194344..195195 Escherichia coli O157:H7 str. EDL933 956894 NP_285865.1 CDS pyrH NC_002655.2 195342 196067 D Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 195342..196067 Escherichia coli O157:H7 str. EDL933 956895 NP_285866.1 CDS frr NC_002655.2 196217 196774 D Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 196217..196774 Escherichia coli O157:H7 str. EDL933 956896 NP_285867.1 CDS yaeM NC_002655.2 196866 198062 D catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase 196866..198062 Escherichia coli O157:H7 str. EDL933 956898 NP_285868.1 CDS yaeS NC_002655.2 198248 199009 D catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; undecaprenyl pyrophosphate synthase 198248..199009 Escherichia coli O157:H7 str. EDL933 956899 NP_285869.2 CDS cdsA NC_002655.2 199022 199879 D catalyzes the synthesis of CDP-diglyceride from CTP and phosphatidate; CDP-diglyceride synthase 199022..199879 Escherichia coli O157:H7 str. EDL933 956900 NP_285870.1 CDS yaeL NC_002655.2 199891 201243 D catalyzes the cleavage of RseA which activates the sigmaE-mediated stress response; zinc metallopeptidase RseP 199891..201243 Escherichia coli O157:H7 str. EDL933 956902 NP_285871.1 CDS yaeT NC_002655.2 201273 203705 D part of a complex with YfgL, YfiO, and NlpB involved in outer membrane protein biosynthesis; involved in the assembly of outer membrane proteins; outer membrane protein assembly factor YaeT 201273..203705 Escherichia coli O157:H7 str. EDL933 956907 NP_285872.1 CDS hlpA NC_002655.2 203826 204311 D periplasmic chaperone 203826..204311 Escherichia coli O157:H7 str. EDL933 956909 NP_285873.1 CDS lpxD NC_002655.2 204315 205340 D adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase 204315..205340 Escherichia coli O157:H7 str. EDL933 956910 NP_285874.1 CDS fabZ NC_002655.2 205445 205900 D in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase 205445..205900 Escherichia coli O157:H7 str. EDL933 956911 NP_285875.1 CDS lpxA NC_002655.2 205904 206692 D catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis; UDP-N-acetylglucosamine acyltransferase 205904..206692 Escherichia coli O157:H7 str. EDL933 956912 NP_285876.1 CDS lpxB NC_002655.2 206692 207840 D catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM; lipid-A-disaccharide synthase 206692..207840 Escherichia coli O157:H7 str. EDL933 956914 NP_285877.1 CDS rnhB NC_002655.2 207837 208433 D RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 207837..208433 Escherichia coli O157:H7 str. EDL933 956915 NP_285878.1 CDS dnaE NC_002655.2 208470 211952 D catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase; DNA polymerase III subunit alpha 208470..211952 Escherichia coli O157:H7 str. EDL933 956917 NP_285879.1 CDS accA NC_002655.2 211965 212924 D catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; acetyl-CoA carboxylase carboxyltransferase subunit alpha 211965..212924 Escherichia coli O157:H7 str. EDL933 956919 NP_285880.1 CDS ldcC NC_002655.2 213023 215164 D lysine decarboxylase 2, constitutive 213023..215164 Escherichia coli O157:H7 str. EDL933 956921 NP_285881.2 CDS yaeR NC_002655.2 215221 215610 D hypothetical protein 215221..215610 Escherichia coli O157:H7 str. EDL933 956922 NP_285882.1 CDS tilS NC_002655.2 215675 216970 D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU; ATP-dependent; responsible for modifying the wobble-base of the CAU anticodon of tRNAIle such that it exhibits proper recognition of the AUA codon rather than the AUG codon and is in turn properly recognized by isoleucyl-tRNA synthetase; tRNA(Ile)-lysidine synthetase 215675..216970 Escherichia coli O157:H7 str. EDL933 956928 NP_285883.1 CDS yaeO NC_002655.2 217023 217283 R Suppresses temperature-sensitive mutations in essential genes by modulating rho-dependent transcription termination; Rho-binding antiterminator complement(217023..217283) Escherichia coli O157:H7 str. EDL933 956930 NP_285884.1 CDS Z0202 NC_002655.2 217636 218094 D hypothetical protein 217636..218094 Escherichia coli O157:H7 str. EDL933 956931 NP_285885.1 CDS yaeJ NC_002655.2 218178 218588 D peptidyl-tRNA hydrolase domain-containing protein 218178..218588 Escherichia coli O157:H7 str. EDL933 956932 NP_285886.1 CDS cutF NC_002655.2 218602 219312 D lipoprotein involved with copper homeostasis and adhesion 218602..219312 Escherichia coli O157:H7 str. EDL933 956934 NP_285887.1 CDS yaeF NC_002655.2 219512 220336 R hypothetical protein complement(219512..220336) Escherichia coli O157:H7 str. EDL933 956935 NP_285888.1 CDS proS NC_002655.2 220389 222107 R catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase complement(220389..222107) Escherichia coli O157:H7 str. EDL933 956936 NP_285889.1 CDS Z0207 NC_002655.2 222218 222925 R hypothetical protein complement(222218..222925) Escherichia coli O157:H7 str. EDL933 956938 NP_285890.1 CDS rcsF NC_002655.2 222922 223326 R outer membrane lipoprotein complement(222922..223326) Escherichia coli O157:H7 str. EDL933 956941 NP_285891.1 CDS metQ NC_002655.2 223444 224259 R DL-methionine transporter substrate-binding subunit complement(223444..224259) Escherichia coli O157:H7 str. EDL933 956942 NP_285892.1 CDS yaeE NC_002655.2 224299 224952 R part of the MetNIQ methionine uptake system; DL-methionine transporter permease complement(224299..224952) Escherichia coli O157:H7 str. EDL933 956943 NP_285893.1 CDS metN NC_002655.2 224945 225976 R part of the metNIQ transport system for methionine; DL-methionine transporter ATP-binding subunit complement(224945..225976) Escherichia coli O157:H7 str. EDL933 956944 NP_285894.1 CDS yaeD NC_002655.2 226164 226739 D Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate; D,D-heptose 1,7-bisphosphate phosphatase 226164..226739 Escherichia coli O157:H7 str. EDL933 956945 NP_285895.1 CDS dkgB NC_002655.2 232497 233300 D catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid; 2,5-diketo-D-gluconate reductase B 232497..233300 Escherichia coli O157:H7 str. EDL933 956971 NP_285896.1 CDS yafC NC_002655.2 233297 234211 R LysR family transcriptional regulator complement(233297..234211) Escherichia coli O157:H7 str. EDL933 956972 NP_285897.1 CDS yafD NC_002655.2 234452 235252 D hypothetical protein 234452..235252 Escherichia coli O157:H7 str. EDL933 956973 NP_285898.1 CDS Z0233 NC_002655.2 235330 236100 D hypothetical protein 235330..236100 Escherichia coli O157:H7 str. EDL933 956974 NP_285899.1 CDS mltD NC_002655.2 236148 237506 R catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; may play a role in recycling muropeptides during cell division and/or cell elongation; in Helicobacter pylori MltD is a endolytic transglycosylase involved mainly in the rearrangement of the peptidoglycan layer of the bacterial cell wall; membrane-bound lytic murein transglycosylase D complement(236148..237506) Escherichia coli O157:H7 str. EDL933 956975 NP_285900.1 CDS gloB NC_002655.2 237578 238333 R catalyzes the hydrolysis of S-D-lactoylglutathione to D-lactic acid and reduced glutathione; plays an important role in cellular detoxification using glutathione; hydroxyacylglutathione hydrolase complement(237578..238333) Escherichia coli O157:H7 str. EDL933 956977 NP_285901.1 CDS yafS NC_002655.2 238349 239089 D hypothetical protein 238349..239089 Escherichia coli O157:H7 str. EDL933 956978 NP_285902.1 CDS rnhA NC_002655.2 239086 239553 R An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids; ribonuclease H complement(239086..239553) Escherichia coli O157:H7 str. EDL933 956979 NP_285903.1 CDS dnaQ NC_002655.2 239618 240349 D 3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon 239618..240349 Escherichia coli O157:H7 str. EDL933 956980 NP_285904.1 CDS Z0243 NC_002655.2 240887 241687 D hypothetical protein 240887..241687 Escherichia coli O157:H7 str. EDL933 956982 NP_285905.1 CDS Z0244 NC_002655.2 241872 242168 R No significant matches; hypothetical protein complement(241872..242168) Escherichia coli O157:H7 str. EDL933 956983 NP_285906.1 CDS Z0245 NC_002655.2 242165 242620 R No significant matches; hypothetical protein complement(242165..242620) Escherichia coli O157:H7 str. EDL933 956985 NP_285907.1 CDS Z0246 NC_002655.2 242617 243213 R No significant matches; hypothetical protein complement(242617..243213) Escherichia coli O157:H7 str. EDL933 956986 NP_285908.1 CDS Z0247 NC_002655.2 243292 243513 R No significant matches; hypothetical protein complement(243292..243513) Escherichia coli O157:H7 str. EDL933 956987 NP_285909.1 CDS Z0248 NC_002655.2 243534 244013 R hypothetical protein complement(243534..244013) Escherichia coli O157:H7 str. EDL933 956988 NP_285910.1 CDS Z0249 NC_002655.2 243979 245478 R No significant matches; hypothetical protein complement(243979..245478) Escherichia coli O157:H7 str. EDL933 956989 NP_285911.1 CDS Z0250 NC_002655.2 245399 248833 R macrophage toxin complement(245399..248833) Escherichia coli O157:H7 str. EDL933 956993 NP_285912.1 CDS Z0251 NC_002655.2 248970 249764 R No significant matches; hypothetical protein complement(248970..249764) Escherichia coli O157:H7 str. EDL933 956995 NP_285913.1 CDS Z0252 NC_002655.2 249761 250381 R No significant matches; hypothetical protein complement(249761..250381) Escherichia coli O157:H7 str. EDL933 956996 NP_285914.1 CDS Z0253 NC_002655.2 250386 251129 R No significant matches; hypothetical protein complement(250386..251129) Escherichia coli O157:H7 str. EDL933 956997 NP_285915.1 CDS Z0254 NC_002655.2 251126 253897 R protease complement(251126..253897) Escherichia coli O157:H7 str. EDL933 956999 NP_285916.1 CDS Z0255 NC_002655.2 253906 254667 R No significant matches; hypothetical protein complement(253906..254667) Escherichia coli O157:H7 str. EDL933 957001 NP_285917.1 CDS Z0256 NC_002655.2 254672 256003 R hypothetical protein complement(254672..256003) Escherichia coli O157:H7 str. EDL933 957002 NP_285918.1 CDS Z0257 NC_002655.2 256006 256530 R No significant matches; hypothetical protein complement(256006..256530) Escherichia coli O157:H7 str. EDL933 957003 NP_285919.1 CDS Z0258 NC_002655.2 256527 257828 R No significant matches; hypothetical protein complement(256527..257828) Escherichia coli O157:H7 str. EDL933 957005 NP_285920.1 CDS Z0259 NC_002655.2 257832 258914 R No significant matches; hypothetical protein complement(257832..258914) Escherichia coli O157:H7 str. EDL933 957006 NP_285921.1 CDS Z0260 NC_002655.2 258878 260728 R No significant matches; hypothetical protein complement(258878..260728) Escherichia coli O157:H7 str. EDL933 957008 NP_285922.1 CDS Z0261 NC_002655.2 260732 261145 R No significant matches; hypothetical protein complement(260732..261145) Escherichia coli O157:H7 str. EDL933 957009 NP_285923.1 CDS Z0262 NC_002655.2 261236 262627 R hypothetical protein complement(261236..262627) Escherichia coli O157:H7 str. EDL933 957010 NP_285924.1 CDS Z0263 NC_002655.2 262678 262902 R No significant matches; hypothetical protein complement(262678..262902) Escherichia coli O157:H7 str. EDL933 957012 NP_285925.1 CDS Z0264 NC_002655.2 262937 263437 R hypothetical protein complement(262937..263437) Escherichia coli O157:H7 str. EDL933 957014 NP_285926.1 CDS Z0265 NC_002655.2 263864 264007 D No significant matches; hypothetical protein 263864..264007 Escherichia coli O157:H7 str. EDL933 957016 NP_285927.1 CDS Z0266 NC_002655.2 264134 264652 D hypothetical protein 264134..264652 Escherichia coli O157:H7 str. EDL933 957018 NP_285928.1 CDS Z0267 NC_002655.2 264862 267003 D hypothetical protein 264862..267003 Escherichia coli O157:H7 str. EDL933 957020 NP_285929.1 CDS Z0268 NC_002655.2 267079 271293 D hypothetical protein 267079..271293 Escherichia coli O157:H7 str. EDL933 957021 NP_285930.1 CDS Z0269 NC_002655.2 271296 271907 D hypothetical protein 271296..271907 Escherichia coli O157:H7 str. EDL933 957022 NP_285931.1 CDS Z0271 NC_002655.2 272653 273789 D hypothetical protein 272653..273789 Escherichia coli O157:H7 str. EDL933 957023 NP_285932.1 CDS Z0272 NC_002655.2 273792 275552 D hypothetical protein 273792..275552 Escherichia coli O157:H7 str. EDL933 957024 NP_285933.1 CDS Z0273 NC_002655.2 275640 275777 R No significant matches; hypothetical protein complement(275640..275777) Escherichia coli O157:H7 str. EDL933 957025 NP_285934.1 CDS Z0274 NC_002655.2 275754 276017 D hypothetical protein 275754..276017 Escherichia coli O157:H7 str. EDL933 957026 NP_285935.1 CDS Z0275 NC_002655.2 276198 277370 D hypothetical protein 276198..277370 Escherichia coli O157:H7 str. EDL933 957027 NP_285936.1 CDS yafV NC_002655.2 277488 278258 R hypothetical protein complement(277488..278258) Escherichia coli O157:H7 str. EDL933 957028 NP_285937.1 CDS ykfE NC_002655.2 278412 278885 D inactivates vertebrate C-type lysozyme; C-lysozyme inhibitor 278412..278885 Escherichia coli O157:H7 str. EDL933 957030 NP_285938.2 CDS fadE NC_002655.2 278928 281372 R functions in fatty acid oxidation; converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA; acyl-CoA dehydrogenase complement(278928..281372) Escherichia coli O157:H7 str. EDL933 957031 NP_285939.1 CDS gmhA NC_002655.2 281612 282190 D catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate; phosphoheptose isomerase 281612..282190 Escherichia coli O157:H7 str. EDL933 957034 NP_285940.1 CDS yafJ NC_002655.2 282295 283062 D amidotransferase 282295..283062 Escherichia coli O157:H7 str. EDL933 957036 NP_285941.1 CDS yafK NC_002655.2 283033 283773 R hypothetical protein complement(283033..283773) Escherichia coli O157:H7 str. EDL933 957037 NP_285942.1 CDS Z0284 NC_002655.2 283929 284132 R hypothetical protein complement(283929..284132) Escherichia coli O157:H7 str. EDL933 957038 NP_285943.1 CDS dinJ NC_002655.2 284208 284468 R damage-inducible protein J complement(284208..284468) Escherichia coli O157:H7 str. EDL933 957039 NP_285944.1 CDS yafL NC_002655.2 284678 285427 D lipoprotein 284678..285427 Escherichia coli O157:H7 str. EDL933 957040 NP_285945.1 CDS yafM NC_002655.2 285603 285899 D hypothetical protein 285603..285899 Escherichia coli O157:H7 str. EDL933 957043 NP_285946.1 CDS fhiA NC_002655.2 286245 287984 R flagellar biosynthesis complement(286245..287984) Escherichia coli O157:H7 str. EDL933 957044 NP_285947.1 CDS mbhA NC_002655.2 287929 288714 D hypothetical protein 287929..288714 Escherichia coli O157:H7 str. EDL933 957045 NP_285948.1 CDS dinP NC_002655.2 288785 289840 D involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV 288785..289840 Escherichia coli O157:H7 str. EDL933 957047 NP_285949.1 CDS yafN NC_002655.2 289892 290185 D antitoxin of the YafO-YafN toxin-antitoxin system 289892..290185 Escherichia coli O157:H7 str. EDL933 957048 NP_285950.1 CDS yafO NC_002655.2 290188 290586 D YafO overproduction induces toxicity; it is believed to be the toxin of a toxin-antitoxin pair; unknown function; toxin YafO 290188..290586 Escherichia coli O157:H7 str. EDL933 957049 NP_285951.1 CDS yafP NC_002655.2 290596 291048 D hypothetical protein 290596..291048 Escherichia coli O157:H7 str. EDL933 957051 NP_285952.1 CDS Z0296 NC_002655.2 291355 291621 D hypothetical protein 291355..291621 Escherichia coli O157:H7 str. EDL933 957054 NP_285953.1 CDS prfH NC_002655.2 291590 292090 D similar to release factor 1 and 2; peptide chain release factor-like protein 291590..292090 Escherichia coli O157:H7 str. EDL933 957057 NP_285954.1 CDS pepD NC_002655.2 292147 293604 R aminoacyl-histidine dipeptidase complement(292147..293604) Escherichia coli O157:H7 str. EDL933 957058 NP_285955.1 CDS gpt NC_002655.2 293865 294323 D catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively; xanthine-guanine phosphoribosyltransferase 293865..294323 Escherichia coli O157:H7 str. EDL933 957059 NP_285956.1 CDS frsA NC_002655.2 294415 295659 D forms a 1:1 complex with the unphosphorylated from of enzyme IIAGlc; FrsA may promote fermentation; fermentation/respiration switch protein 294415..295659 Escherichia coli O157:H7 str. EDL933 957063 NP_285957.1 CDS crl NC_002655.2 295717 296118 D involved in the expression of csgBA which is involved in curli formation; interacts with sigmaS; DNA-binding transcriptional regulator Crl 295717..296118 Escherichia coli O157:H7 str. EDL933 957064 NP_285958.1 CDS phoE NC_002655.2 296157 297212 R outer membrane phosphoporin protein E complement(296157..297212) Escherichia coli O157:H7 str. EDL933 957066 NP_285959.1 CDS proB NC_002655.2 297500 298603 D catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase 297500..298603 Escherichia coli O157:H7 str. EDL933 957067 NP_285960.1 CDS proA NC_002655.2 298615 299868 D Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase 298615..299868 Escherichia coli O157:H7 str. EDL933 957068 NP_285961.1 CDS intH NC_002655.2 300073 301047 R integrase for prophage CP-933H complement(300073..301047) Escherichia coli O157:H7 str. EDL933 957072 NP_285962.1 CDS Z0308 NC_002655.2 301423 301812 R hypothetical protein complement(301423..301812) Escherichia coli O157:H7 str. EDL933 957073 NP_285963.1 CDS Z0309 NC_002655.2 301940 302653 R cI repressor protein for prophage CP-933H complement(301940..302653) Escherichia coli O157:H7 str. EDL933 957076 NP_285964.1 CDS Z0310 NC_002655.2 303073 303366 D cII antiterminator protein for prophage CP-933H 303073..303366 Escherichia coli O157:H7 str. EDL933 957081 NP_285965.1 CDS Z0311 NC_002655.2 303399 304007 D hypothetical protein 303399..304007 Escherichia coli O157:H7 str. EDL933 957082 NP_285966.1 CDS Z0312 NC_002655.2 303947 304321 D hypothetical protein 303947..304321 Escherichia coli O157:H7 str. EDL933 957085 NP_285967.1 CDS Z0313 NC_002655.2 304318 304629 D No significant matches; hypothetical protein 304318..304629 Escherichia coli O157:H7 str. EDL933 957087 NP_285968.1 CDS Z0314 NC_002655.2 304629 305339 D hypothetical protein 304629..305339 Escherichia coli O157:H7 str. EDL933 957088 NP_285969.1 CDS Z0315 NC_002655.2 305351 305803 D hypothetical protein 305351..305803 Escherichia coli O157:H7 str. EDL933 957089 NP_285970.1 CDS Z0316 NC_002655.2 305775 306368 R hypothetical protein complement(305775..306368) Escherichia coli O157:H7 str. EDL933 957090 NP_285971.1 CDS Z0317 NC_002655.2 306368 306865 R tail fiber protein from prophage CP-933H complement(306368..306865) Escherichia coli O157:H7 str. EDL933 957092 NP_285972.1 CDS pinH NC_002655.2 306856 307446 D DNA invertase from prophage CP-933H 306856..307446 Escherichia coli O157:H7 str. EDL933 957093 NP_285973.1 CDS Z0319 NC_002655.2 307504 308277 R hypothetical protein complement(307504..308277) Escherichia coli O157:H7 str. EDL933 957094 NP_285974.1 CDS Z0321 NC_002655.2 309101 309844 D AraC family transcriptional regulator 309101..309844 Escherichia coli O157:H7 str. EDL933 957095 NP_285975.1 CDS Z0322 NC_002655.2 309886 310251 R hypothetical protein complement(309886..310251) Escherichia coli O157:H7 str. EDL933 957096 NP_285976.1 CDS Z0324 NC_002655.2 310756 311988 D integrase for prophage CP-933I 310756..311988 Escherichia coli O157:H7 str. EDL933 957097 NP_285977.1 CDS Z0325 NC_002655.2 311992 312408 D No significant matches; hypothetical protein 311992..312408 Escherichia coli O157:H7 str. EDL933 957099 NP_285978.1 CDS Z0326 NC_002655.2 312381 312998 D No significant matches; hypothetical protein 312381..312998 Escherichia coli O157:H7 str. EDL933 957100 NP_285979.1 CDS Z0327 NC_002655.2 312998 313456 D No significant matches; hypothetical protein 312998..313456 Escherichia coli O157:H7 str. EDL933 957102 NP_285980.1 CDS Z0328 NC_002655.2 313449 314081 D No significant matches; hypothetical protein 313449..314081 Escherichia coli O157:H7 str. EDL933 957104 NP_285981.1 CDS Z0330 NC_002655.2 314112 314702 D No significant matches; hypothetical protein 314112..314702 Escherichia coli O157:H7 str. EDL933 957106 NP_285982.1 CDS Z0331 NC_002655.2 314702 315268 D No significant matches; hypothetical protein 314702..315268 Escherichia coli O157:H7 str. EDL933 957107 NP_285983.1 CDS Z0332 NC_002655.2 315678 315950 R activator encoded in prophage CP-933I complement(315678..315950) Escherichia coli O157:H7 str. EDL933 957109 NP_285984.1 CDS psuI NC_002655.2 315956 316507 R polarity suppression protein encoded in CP-933I complement(315956..316507) Escherichia coli O157:H7 str. EDL933 957110 NP_285985.1 CDS sidI NC_002655.2 316504 317256 R capsid morphogenesis protein encoded in CP-933I complement(316504..317256) Escherichia coli O157:H7 str. EDL933 957111 NP_285986.1 CDS Z0335 NC_002655.2 317659 317829 D No significant matches; hypothetical protein 317659..317829 Escherichia coli O157:H7 str. EDL933 957112 NP_285987.1 CDS Z0336 NC_002655.2 318190 318450 D regulatory protein encoded in prophage CP-933I 318190..318450 Escherichia coli O157:H7 str. EDL933 957114 NP_285988.1 CDS Z0337 NC_002655.2 318447 319004 D regulator encoded in prophage CP-933I 318447..319004 Escherichia coli O157:H7 str. EDL933 957116 NP_285989.1 CDS Z0338 NC_002655.2 319222 319545 D hypothetical protein 319222..319545 Escherichia coli O157:H7 str. EDL933 957117 NP_285990.1 CDS Z0339 NC_002655.2 319502 321892 D alpha replication protein of prophage CP-933I 319502..321892 Escherichia coli O157:H7 str. EDL933 957118 NP_285991.1 CDS Z0340 NC_002655.2 322025 322981 R hypothetical protein complement(322025..322981) Escherichia coli O157:H7 str. EDL933 957120 NP_285993.1 CDS Z0342 NC_002655.2 323657 324556 R LysR family transcriptional regulator complement(323657..324556) Escherichia coli O157:H7 str. EDL933 957123 NP_285994.1 CDS Z0343 NC_002655.2 324655 325377 D oxidoreductase 324655..325377 Escherichia coli O157:H7 str. EDL933 957124 NP_285995.1 CDS Z0344 NC_002655.2 325544 325822 D No significant matches; hypothetical protein 325544..325822 Escherichia coli O157:H7 str. EDL933 957130 NP_285996.1 CDS Z0345 NC_002655.2 326097 326246 D No significant matches; hypothetical protein 326097..326246 Escherichia coli O157:H7 str. EDL933 957131 NP_285997.1 CDS Z0346 NC_002655.2 326525 327409 R LysR family transcriptional regulator complement(326525..327409) Escherichia coli O157:H7 str. EDL933 957132 NP_285998.1 CDS Z0347 NC_002655.2 327673 328731 D hypothetical protein 327673..328731 Escherichia coli O157:H7 str. EDL933 957133 NP_285999.1 CDS Z0348 NC_002655.2 328807 330000 D transcriptional regulator 328807..330000 Escherichia coli O157:H7 str. EDL933 957135 NP_286000.1 CDS yagQ NC_002655.2 330179 331135 R hypothetical protein complement(330179..331135) Escherichia coli O157:H7 str. EDL933 957137 NP_286001.1 CDS yagR NC_002655.2 331145 333343 R hypothetical protein complement(331145..333343) Escherichia coli O157:H7 str. EDL933 957138 NP_286002.1 CDS yagS NC_002655.2 333340 334296 R hypothetical protein complement(333340..334296) Escherichia coli O157:H7 str. EDL933 957139 NP_286003.1 CDS yagT NC_002655.2 334293 334982 R xanthine dehydrogenase iron-sulfur-binding subunit complement(334293..334982) Escherichia coli O157:H7 str. EDL933 957140 NP_286004.1 CDS yagU NC_002655.2 335400 336014 D hypothetical protein 335400..336014 Escherichia coli O157:H7 str. EDL933 957141 NP_286005.1 CDS ykgJ NC_002655.2 336262 336591 R ferredoxin complement(336262..336591) Escherichia coli O157:H7 str. EDL933 957145 NP_286006.1 CDS yagV NC_002655.2 336904 337659 R hypothetical protein complement(336904..337659) Escherichia coli O157:H7 str. EDL933 957146 NP_286007.1 CDS yagW NC_002655.2 337583 339226 R receptor complement(337583..339226) Escherichia coli O157:H7 str. EDL933 957147 NP_286008.1 CDS yagX NC_002655.2 339216 341741 R hypothetical protein complement(339216..341741) Escherichia coli O157:H7 str. EDL933 957149 NP_286009.1 CDS yagY NC_002655.2 341767 342435 R hypothetical protein complement(341767..342435) Escherichia coli O157:H7 str. EDL933 957150 NP_286010.1 CDS yagZ NC_002655.2 342493 343080 R hypothetical protein complement(342493..343080) Escherichia coli O157:H7 str. EDL933 957151 NP_286011.1 CDS ykgK NC_002655.2 343155 343745 R regulator complement(343155..343745) Escherichia coli O157:H7 str. EDL933 957152 NP_286012.1 CDS Z0362 NC_002655.2 344151 344375 R No significant matches; hypothetical protein complement(344151..344375) Escherichia coli O157:H7 str. EDL933 957155 NP_286013.1 CDS ykgL NC_002655.2 344522 344713 D hypothetical protein 344522..344713 Escherichia coli O157:H7 str. EDL933 957160 NP_286014.1 CDS rpmE2 NC_002655.2 344923 345186 R RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 complement(344923..345186) Escherichia coli O157:H7 str. EDL933 957162 NP_286015.1 CDS Z0365 NC_002655.2 345429 345830 D hypothetical protein 345429..345830 Escherichia coli O157:H7 str. EDL933 957163 NP_286016.1 CDS Z0366 NC_002655.2 345827 346174 D hypothetical protein 345827..346174 Escherichia coli O157:H7 str. EDL933 957164 NP_286017.1 CDS Z0367 NC_002655.2 346224 347762 D hypothetical protein 346224..347762 Escherichia coli O157:H7 str. EDL933 957165 NP_286018.1 CDS Z0369 NC_002655.2 348575 349717 R oxidoreductase complement(348575..349717) Escherichia coli O157:H7 str. EDL933 957166 NP_286019.1 CDS Z0370 NC_002655.2 349953 350873 R hypothetical protein complement(349953..350873) Escherichia coli O157:H7 str. EDL933 957168 NP_286020.1 CDS Z0371 NC_002655.2 350967 351956 D LysR family transcriptional regulator 350967..351956 Escherichia coli O157:H7 str. EDL933 957169 NP_286021.1 CDS Z0372 NC_002655.2 352244 352600 R No significant matches; hypothetical protein complement(352244..352600) Escherichia coli O157:H7 str. EDL933 957171 NP_286022.1 CDS Z0373 NC_002655.2 352631 352759 D No significant matches; hypothetical protein 352631..352759 Escherichia coli O157:H7 str. EDL933 957173 NP_286023.1 CDS Z0374 NC_002655.2 352793 353368 R hypothetical protein complement(352793..353368) Escherichia coli O157:H7 str. EDL933 957174 NP_286024.1 CDS eaeH NC_002655.2 353934 358187 D adhesin 353934..358187 Escherichia coli O157:H7 str. EDL933 957175 NP_286025.1 CDS ykgA NC_002655.2 358308 359198 R AraC family transcriptional regulator complement(358308..359198) Escherichia coli O157:H7 str. EDL933 957184 NP_286026.1 CDS Z0377 NC_002655.2 359399 360283 D dehydrogenase 359399..360283 Escherichia coli O157:H7 str. EDL933 957185 NP_286027.1 CDS ykgB NC_002655.2 360443 361036 R hypothetical protein complement(360443..361036) Escherichia coli O157:H7 str. EDL933 957187 NP_286029.1 CDS ykgI NC_002655.2 361048 361299 R hypothetical protein complement(361048..361299) Escherichia coli O157:H7 str. EDL933 957190 NP_286030.2 CDS ykgC NC_002655.2 361393 362718 R Involved in disulfide oxidoreductase activity and electron transport; pyridine nucleotide-disulfide oxidoreductase complement(361393..362718) Escherichia coli O157:H7 str. EDL933 957192 NP_286031.1 CDS ykgD NC_002655.2 362944 363798 D AraC family transcriptional regulator 362944..363798 Escherichia coli O157:H7 str. EDL933 957193 NP_286032.1 CDS ykgE NC_002655.2 364325 365044 D dehydrogenase subunit 364325..365044 Escherichia coli O157:H7 str. EDL933 957194 NP_286033.1 CDS ykgF NC_002655.2 365055 366482 D hypothetical protein 365055..366482 Escherichia coli O157:H7 str. EDL933 957196 NP_286034.2 CDS ykgG NC_002655.2 366475 367170 D hypothetical protein 366475..367170 Escherichia coli O157:H7 str. EDL933 957198 NP_286035.1 CDS Z0387 NC_002655.2 367125 367337 R hypothetical protein complement(367125..367337) Escherichia coli O157:H7 str. EDL933 957199 NP_286036.1 CDS Z0388 NC_002655.2 367665 368081 R hypothetical protein complement(367665..368081) Escherichia coli O157:H7 str. EDL933 957201 NP_286037.1 CDS Z0389 NC_002655.2 368263 368505 R hypothetical protein complement(368263..368505) Escherichia coli O157:H7 str. EDL933 957202 NP_286038.1 CDS Z0390 NC_002655.2 368429 369538 R hypothetical protein complement(368429..369538) Escherichia coli O157:H7 str. EDL933 957204 NP_286039.1 CDS Z0391 NC_002655.2 369565 370326 R No significant matches; hypothetical protein complement(369565..370326) Escherichia coli O157:H7 str. EDL933 957205 NP_286040.1 CDS Z0392 NC_002655.2 370480 370956 R No significant matches; hypothetical protein complement(370480..370956) Escherichia coli O157:H7 str. EDL933 957206 NP_286041.1 CDS Z0393 NC_002655.2 371156 371311 R No significant matches; hypothetical protein complement(371156..371311) Escherichia coli O157:H7 str. EDL933 957207 NP_286042.1 CDS Z0394 NC_002655.2 371604 371762 R hypothetical protein complement(371604..371762) Escherichia coli O157:H7 str. EDL933 957208 NP_286043.1 CDS Z0395 NC_002655.2 371783 372166 R hypothetical protein complement(371783..372166) Escherichia coli O157:H7 str. EDL933 957209 NP_286044.1 CDS Z0397 NC_002655.2 372972 373223 D No significant matches; hypothetical protein 372972..373223 Escherichia coli O157:H7 str. EDL933 957210 NP_286045.1 CDS betA NC_002655.2 373225 374913 R catalyzes the oxidation of choline to betaine aldehyde and betain aldehyde to glycine betaine; choline dehydrogenase complement(373225..374913) Escherichia coli O157:H7 str. EDL933 957211 NP_286046.1 CDS betB NC_002655.2 374927 376399 R catalyzes the formation of betaine from betaine aldehyde; betaine aldehyde dehydrogenase complement(374927..376399) Escherichia coli O157:H7 str. EDL933 957212 NP_286047.1 CDS betI NC_002655.2 376413 377000 R HTH-type; bet1; Repressor involved in choline regulation of the bet genes; transcriptional regulator BetI complement(376413..377000) Escherichia coli O157:H7 str. EDL933 957214 NP_286048.1 CDS betT NC_002655.2 377129 379162 D proton-motive-force-driven choline transporter; choline transport protein BetT 377129..379162 Escherichia coli O157:H7 str. EDL933 957215 NP_286049.1 CDS Z0402 NC_002655.2 379670 383719 D beta-barrel outer membrane protein 379670..383719 Escherichia coli O157:H7 str. EDL933 957216 NP_286050.1 CDS yahA NC_002655.2 383852 384949 D hypothetical protein 383852..384949 Escherichia coli O157:H7 str. EDL933 957219 NP_286051.1 CDS Z0404 NC_002655.2 384991 385251 R hypothetical protein complement(384991..385251) Escherichia coli O157:H7 str. EDL933 957221 NP_286052.1 CDS Z0405 NC_002655.2 385212 385922 R hypothetical protein complement(385212..385922) Escherichia coli O157:H7 str. EDL933 957224 NP_286053.1 CDS Z0406 NC_002655.2 386014 386316 R hypothetical protein complement(386014..386316) Escherichia coli O157:H7 str. EDL933 957225 NP_286054.1 CDS yahD NC_002655.2 386779 387384 D transcription factor 386779..387384 Escherichia coli O157:H7 str. EDL933 957226 NP_286055.1 CDS yahE NC_002655.2 387424 388287 D hypothetical protein 387424..388287 Escherichia coli O157:H7 str. EDL933 957227 NP_286056.1 CDS yahF NC_002655.2 388277 389824 D oxidoreductase subunit 388277..389824 Escherichia coli O157:H7 str. EDL933 957228 NP_286057.1 CDS yahG NC_002655.2 389824 391242 D hypothetical protein 389824..391242 Escherichia coli O157:H7 str. EDL933 957234 NP_286058.1 CDS yahI NC_002655.2 391757 392707 D forms a homodimer; may be used to synthesize carbomyl phosphate from ATP and carbamate; carbamate kinase 391757..392707 Escherichia coli O157:H7 str. EDL933 957235 NP_286059.1 CDS yahJ NC_002655.2 392717 394099 D metallo-dependent hydrolase superfamily; deaminase with metallo-dependent hydrolase domain; deaminase 392717..394099 Escherichia coli O157:H7 str. EDL933 957236 NP_286060.1 CDS Z0414 NC_002655.2 394398 394808 D hypothetical protein 394398..394808 Escherichia coli O157:H7 str. EDL933 957239 NP_286061.1 CDS Z0415 NC_002655.2 395059 396045 D periplasmic binding protein, substrate ribose 395059..396045 Escherichia coli O157:H7 str. EDL933 957242 NP_286062.1 CDS Z0416 NC_002655.2 396094 396354 D ABC transporter ATP-binding protein 396094..396354 Escherichia coli O157:H7 str. EDL933 957243 NP_286063.1 CDS Z0417 NC_002655.2 396400 397578 D ABC transporter ATP-binding protein 396400..397578 Escherichia coli O157:H7 str. EDL933 957244 NP_286064.1 CDS Z0418 NC_002655.2 397571 398542 D permease 397571..398542 Escherichia coli O157:H7 str. EDL933 957245 NP_286065.1 CDS Z0419 NC_002655.2 398539 399495 D permease 398539..399495 Escherichia coli O157:H7 str. EDL933 957246 NP_286066.1 CDS yahK NC_002655.2 399582 400631 D oxidoreductase 399582..400631 Escherichia coli O157:H7 str. EDL933 957248 NP_286067.1 CDS yahL NC_002655.2 400874 401689 D hypothetical protein 400874..401689 Escherichia coli O157:H7 str. EDL933 957249 NP_286068.1 CDS Z0423 NC_002655.2 402210 402350 D hypothetical protein 402210..402350 Escherichia coli O157:H7 str. EDL933 957252 NP_286069.1 CDS yahN NC_002655.2 402367 403038 R cytochrome subunit of dehydrogenase complement(402367..403038) Escherichia coli O157:H7 str. EDL933 957253 NP_286070.1 CDS yahO NC_002655.2 403185 403460 D hypothetical protein 403185..403460 Escherichia coli O157:H7 str. EDL933 957254 NP_286071.1 CDS prpR NC_002655.2 403558 405144 R regulator for prp operon complement(403558..405144) Escherichia coli O157:H7 str. EDL933 957255 NP_286072.1 CDS prpB NC_002655.2 405383 406273 D catalyzes the formation of pyruvate and succinate from 2-methylisocitrate; 2-methylisocitrate lyase 405383..406273 Escherichia coli O157:H7 str. EDL933 957256 NP_286073.1 CDS prpC NC_002655.2 406429 407598 D catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate; also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity; methylcitrate synthase 406429..407598 Escherichia coli O157:H7 str. EDL933 957257 NP_286074.1 CDS prpD NC_002655.2 407632 409083 D functions in propionate metabolism; involved in isomerization of (2S,3S)-methylcitrate to (2R,3S)-methylisocitrate; also encodes minor aconitase or dehydratase activity; aconitase C; 2-methylcitrate dehydratase 407632..409083 Escherichia coli O157:H7 str. EDL933 957258 NP_286075.1 CDS prpE NC_002655.2 409123 411009 D catalyzes the formation of propionyl-CoA using propionate as a substrate; PrpE from Ralstonia solanacearum can produce acetyl-, propionyl-, butyryl- and acrylyl-coenzyme A, and Salmonella enterica produces propionyl- and butyryl-coenzyme A; not expressed in Escherichia coli when grown on propionate/minimal media; ATP-dependent; propionyl-CoA synthetase 409123..411009 Escherichia coli O157:H7 str. EDL933 957259 NP_286076.1 CDS Z0431 NC_002655.2 411372 411509 R No significant matches; hypothetical protein complement(411372..411509) Escherichia coli O157:H7 str. EDL933 957260 NP_286077.1 CDS codB NC_002655.2 411903 413162 D cytosine permease 411903..413162 Escherichia coli O157:H7 str. EDL933 957261 NP_286078.1 CDS codA NC_002655.2 413152 414435 D Catalyzes the deamination of cytosine to uracil and ammonia; cytosine deaminase 413152..414435 Escherichia coli O157:H7 str. EDL933 957262 NP_286079.1 CDS cynR NC_002655.2 414568 415467 R controls the expression of the cynTSX operon involved in degrading and using cyanate as a sole nitrogen source; DNA-binding transcriptional regulator CynR complement(414568..415467) Escherichia coli O157:H7 str. EDL933 957263 NP_286080.1 CDS cynT NC_002655.2 415577 416236 D carbonic anhydrase 415577..416236 Escherichia coli O157:H7 str. EDL933 957265 NP_286081.1 CDS cynS NC_002655.2 416267 416737 D catalyzes the reaction of cyanate and bicarbonate to produce ammonia and carbon dioxide; cyanate hydratase 416267..416737 Escherichia coli O157:H7 str. EDL933 957266 NP_286082.1 CDS cynX NC_002655.2 416770 417924 D MFS transporter family member induced in the presence of cyanate as part of a 3 gene operon; not essential; cyanate transporter 416770..417924 Escherichia coli O157:H7 str. EDL933 957267 NP_286083.1 CDS lacA NC_002655.2 418027 418638 R transfers acetyl group from acetyl-CoA to the 6-hydroxyl of galactopyranosides; exact physiological role is unknown; galactoside O-acetyltransferase complement(418027..418638) Escherichia coli O157:H7 str. EDL933 957269 NP_286084.1 CDS lacY NC_002655.2 418704 419957 R lactose/proton symporter; mediates lactose/proton symport through the membrane by utilizing the proton gradient to drive transport of galactosides; member of major facilitator superfamily; functions as a monomer with 12 transmembrane segments; galactoside permease complement(418704..419957) Escherichia coli O157:H7 str. EDL933 957270 NP_286085.1 CDS lacZ NC_002655.2 420009 423083 R forms a homotetramer; hydrolyzes lactose disaccharide to galactose and glucose; converts lactose to allolactose which is the natural inducer of the lac operon; beta-D-galactosidase complement(420009..423083) Escherichia coli O157:H7 str. EDL933 957271 NP_286086.1 CDS lacI NC_002655.2 423206 424288 R transcriptional repressor of lac operon; forms a homotetramer as a dimer of dimers; binds specific sites in lac operon resulting in DNA looping between the operators; binds allolactose as inducer; lac repressor complement(423206..424288) Escherichia coli O157:H7 str. EDL933 957273 NP_286087.1 CDS Z0442 NC_002655.2 424325 425278 R AraC family transcriptional regulator complement(424325..425278) Escherichia coli O157:H7 str. EDL933 957278 NP_286088.1 CDS Z0443 NC_002655.2 425298 426074 R hypothetical protein complement(425298..426074) Escherichia coli O157:H7 str. EDL933 957280 NP_286089.1 CDS mhpR NC_002655.2 426189 427061 R activator of 3-phenylpropionic acid catabolism; DNA-binding transcriptional activator MhpR complement(426189..427061) Escherichia coli O157:H7 str. EDL933 957281 NP_286090.1 CDS mhpA NC_002655.2 427213 428877 D catalyzes the formation of 3-(2,3-dihydroxyphenyl)propionate from 3-(3-hydroxyphenyl)propionate; 3-(3-hydroxyphenyl)propionate hydroxylase 427213..428877 Escherichia coli O157:H7 str. EDL933 957286 NP_286091.1 CDS mhpB NC_002655.2 428879 429823 D catalyzes the cleavage of 3-(2,3-dihydroxyphenyl) propionate into 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate; part of the 3-phenylpropionic acid degradation pathway; member of the protocatechuate 4,5-dioxygenase; 3-(2,3-dihydroxyphenyl)propionate dioxygenase 428879..429823 Escherichia coli O157:H7 str. EDL933 957287 NP_286092.1 CDS mhpC NC_002655.2 429778 430707 D 2-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase 429778..430707 Escherichia coli O157:H7 str. EDL933 957288 NP_286093.1 CDS mhpD NC_002655.2 430717 431526 D catalyzes the formation of 2-keto-4-hydroxypentanoic acid from 2-hydroxypentadienoic acid; 2-keto-4-pentenoate hydratase 430717..431526 Escherichia coli O157:H7 str. EDL933 957289 NP_286094.1 CDS mhpF NC_002655.2 431523 432473 D catalyzes the formation of acetyl-CoA from acetalaldehyde; acetaldehyde dehydrogenase 431523..432473 Escherichia coli O157:H7 str. EDL933 957291 NP_286095.1 CDS mhpE NC_002655.2 432470 433483 D catalyzes the formation of pyruvate and acetaldehyde from 4-hydroxy-2-ketovaleric acid; involved in the degradation of phenylpropionate; 4-hydroxy-2-ketovalerate aldolase 432470..433483 Escherichia coli O157:H7 str. EDL933 957292 NP_286096.2 CDS mhpT NC_002655.2 433659 434870 D 3-hydroxyphenylpropionic transporter MhpT 433659..434870 Escherichia coli O157:H7 str. EDL933 957293 NP_286097.2 CDS yaiL NC_002655.2 434972 435511 D nucleoprotein/polynucleotide-associated enzyme 434972..435511 Escherichia coli O157:H7 str. EDL933 957294 NP_286098.1 CDS yaiM NC_002655.2 435636 436469 R esterase complement(435636..436469) Escherichia coli O157:H7 str. EDL933 957295 NP_286099.1 CDS adhC NC_002655.2 436562 437671 R glutathione-dependent formaldehyde dehydrogenase complement(436562..437671) Escherichia coli O157:H7 str. EDL933 957296 NP_286100.1 CDS yaiN NC_002655.2 437706 438002 R formaldehyde-induced negative regulator of the frmRAB operon; regulator protein FrmR complement(437706..438002) Escherichia coli O157:H7 str. EDL933 957297 NP_286101.2 CDS fbpC NC_002655.2 438141 439187 R Part of the ABC transporter complex FbpABC involved in Fe(3+) ions import; ferric transporter ATP-binding subunit complement(438141..439187) Escherichia coli O157:H7 str. EDL933 957301 NP_286102.1 CDS afuB NC_002655.2 439199 441277 R permease component of transport system for ferric iron complement(439199..441277) Escherichia coli O157:H7 str. EDL933 957302 NP_286103.1 CDS afuA NC_002655.2 441346 442377 R periplasmic ferric iron-binding protein complement(441346..442377) Escherichia coli O157:H7 str. EDL933 957305 NP_286104.1 CDS Z0461 NC_002655.2 442374 443678 R permease; hexosephosphate transport complement(442374..443678) Escherichia coli O157:H7 str. EDL933 957306 NP_286105.1 CDS Z0462 NC_002655.2 443763 445304 R sensor kinase complement(443763..445304) Escherichia coli O157:H7 str. EDL933 957307 NP_286106.1 CDS Z0463 NC_002655.2 445304 445933 R response regulator; hexosephosphate transport complement(445304..445933) Escherichia coli O157:H7 str. EDL933 957308 NP_286107.1 CDS tauA NC_002655.2 446236 447198 D with TauB and TauC is responsible for taurine uptake.; taurine transporter substrate binding subunit 446236..447198 Escherichia coli O157:H7 str. EDL933 957309 NP_286108.1 CDS tauB NC_002655.2 447211 447978 D Part of the ABC transporter complex tauABC involved in taurine import; taurine transporter ATP-binding subunit 447211..447978 Escherichia coli O157:H7 str. EDL933 957311 NP_286109.1 CDS tauC NC_002655.2 447975 448802 D taurine transporter subunit 447975..448802 Escherichia coli O157:H7 str. EDL933 957312 NP_286110.1 CDS tauD NC_002655.2 448799 449650 D catalyzes the conversion of taurine (2-aminoethanesulfonate) to sulfite and aminoacetaldehyde concurrently with the conversion of alpha-ketoglutarate to succinate and carbon dioxide; non-heme iron oxidase; allows the use of taurine as an alternative sulfur source; forms homodimers; taurine dioxygenase 448799..449650 Escherichia coli O157:H7 str. EDL933 957313 NP_286111.1 CDS hemB NC_002655.2 449757 450764 R catalyzes the formation of porphobilinogen from 5-aminolevulinate; delta-aminolevulinic acid dehydratase complement(449757..450764) Escherichia coli O157:H7 str. EDL933 957314 NP_286112.1 CDS Z0469 NC_002655.2 451257 454199 D hypothetical protein 451257..454199 Escherichia coli O157:H7 str. EDL933 957315 NP_286113.1 CDS yaiV NC_002655.2 454242 454910 D DNA-binding transcriptional regulator 454242..454910 Escherichia coli O157:H7 str. EDL933 957317 NP_286114.1 CDS yaiH NC_002655.2 454911 456068 R this protein has no known enzymatic function; beta-lactam binding protein AmpH complement(454911..456068) Escherichia coli O157:H7 str. EDL933 957318 NP_286115.1 CDS sbmA NC_002655.2 456420 457640 D in Escherichia coli SbmA is involved in uptake of microcin J25; functions along with FhuA, TonB, and ExbB/D in this capacity; in Sinorhizobium meliloti, BacA is essential and required for symbiosis; defects appear to affect the cell envelope; transporter 456420..457640 Escherichia coli O157:H7 str. EDL933 957320 NP_286116.1 CDS yaiW NC_002655.2 457653 458747 D hypothetical protein 457653..458747 Escherichia coli O157:H7 str. EDL933 957321 NP_286117.1 CDS Z0475 NC_002655.2 458806 459114 R hypothetical protein complement(458806..459114) Escherichia coli O157:H7 str. EDL933 957322 NP_286118.1 CDS Z0476 NC_002655.2 459242 459586 D hypothetical protein 459242..459586 Escherichia coli O157:H7 str. EDL933 957324 NP_286119.1 CDS ddl NC_002655.2 459610 460704 R D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A complement(459610..460704) Escherichia coli O157:H7 str. EDL933 957325 NP_286120.1 CDS yaiB NC_002655.2 461167 461427 D hypothetical protein 461167..461427 Escherichia coli O157:H7 str. EDL933 957326 NP_286121.1 CDS phoA NC_002655.2 461459 462943 D alkaline phosphatase 461459..462943 Escherichia coli O157:H7 str. EDL933 957327 NP_286122.1 CDS psiF NC_002655.2 463044 463382 D hypothetical protein 463044..463382 Escherichia coli O157:H7 str. EDL933 957328 NP_286123.1 CDS adrA NC_002655.2 463484 464599 D catalyzes the conversion of 2 GTP into c-di-GMP; adrA overexpression induces cellulose biosynthesis, cell adherence to abiotic surfaces and swimming and swarming motility; AdrA acts post-transcriptionally on the bcsABZC operon activating cellulose biosynthesis; diguanylate cyclase AdrA 463484..464599 Escherichia coli O157:H7 str. EDL933 957331 NP_286124.1 CDS proC NC_002655.2 464616 465425 R catalyzes the formation of L-proline from pyrroline-5-carboxylate; pyrroline-5-carboxylate reductase complement(464616..465425) Escherichia coli O157:H7 str. EDL933 957332 NP_286125.2 CDS Z0483 NC_002655.2 465545 466003 D hypothetical protein 465545..466003 Escherichia coli O157:H7 str. EDL933 957333 NP_286126.1 CDS aroL NC_002655.2 466186 466710 D type II enzyme similar to type I but differentially regulated and with a lower Km; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase 466186..466710 Escherichia coli O157:H7 str. EDL933 957334 NP_286127.1 CDS yaiA NC_002655.2 466760 466951 D hypothetical protein 466760..466951 Escherichia coli O157:H7 str. EDL933 957335 NP_286128.1 CDS aroM NC_002655.2 467209 467886 D hypothetical protein 467209..467886 Escherichia coli O157:H7 str. EDL933 957336 NP_286129.1 CDS yaiE NC_002655.2 467958 468242 D hypothetical protein 467958..468242 Escherichia coli O157:H7 str. EDL933 957337 NP_286130.1 CDS Z0489 NC_002655.2 470384 470665 D hypothetical protein 470384..470665 Escherichia coli O157:H7 str. EDL933 957339 NP_286131.1 CDS Z0491 NC_002655.2 470662 471111 D No significant matches; hypothetical protein 470662..471111 Escherichia coli O157:H7 str. EDL933 957340 NP_286132.1 CDS rdgC NC_002655.2 471196 472107 R Required for efficient pilin antigenic variation; recombination associated protein complement(471196..472107) Escherichia coli O157:H7 str. EDL933 957342 NP_286133.2 CDS yajF NC_002655.2 472232 473140 D catalyzes phosphorylation of fructose; cytosolic enzyme; fructokinase 472232..473140 Escherichia coli O157:H7 str. EDL933 957343 NP_286134.1 CDS araJ NC_002655.2 473283 474467 R member of the major facilitator superfamily (MFS) of transporters; unknown function; may be associated with transport or processing of arabinose polymers; MFS transport protein AraJ complement(473283..474467) Escherichia coli O157:H7 str. EDL933 957344 NP_286135.1 CDS sbcC NC_002655.2 474593 477736 R with SbcD cleaves DNA hairpin structures; also has 5' single-strand endonuclease activity; exonuclease SbcC complement(474593..477736) Escherichia coli O157:H7 str. EDL933 957347 NP_286136.1 CDS sbcD NC_002655.2 477733 478935 R with SbcC cleaves DNA hairpin structure, also has 5' single-strand endonuclease activity; exonuclease SbcD complement(477733..478935) Escherichia coli O157:H7 str. EDL933 957348 NP_286137.1 CDS phoB NC_002655.2 479125 479814 D two component response regulator for the phosphate regulon; PhoR phosphorylates PhoB; transcriptional regulator PhoB 479125..479814 Escherichia coli O157:H7 str. EDL933 957349 NP_286138.1 CDS phoR NC_002655.2 479872 481167 D membrane-associated histidine protein kinase that phosphorylates phoB in response to environmental signals as part of the two-component phosphate regulatory system phoR/phoB; phosphate regulon sensor protein 479872..481167 Escherichia coli O157:H7 str. EDL933 957350 NP_286139.1 CDS brnQ NC_002655.2 481574 482893 D branched chain amino acid transport system II carrier protein 481574..482893 Escherichia coli O157:H7 str. EDL933 957352 NP_286140.1 CDS proY NC_002655.2 482969 484342 D cryptic permease that may be involved in the transport of proline across the inner membrane; in Salmonella typhimurium, the proY gene is silent unless overexpressed on a multicopy plasmid or activated by a proZ mutation; permease 482969..484342 Escherichia coli O157:H7 str. EDL933 957353 NP_286141.1 CDS malZ NC_002655.2 484498 486315 D maltodextrin glucosidase 484498..486315 Escherichia coli O157:H7 str. EDL933 957355 NP_286142.1 CDS Z0502 NC_002655.2 486503 487948 D hypothetical protein 486503..487948 Escherichia coli O157:H7 str. EDL933 957356 NP_286143.1 CDS yajB NC_002655.2 487969 488550 R Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP; ACP phosphodieterase complement(487969..488550) Escherichia coli O157:H7 str. EDL933 957357 NP_286144.1 CDS queA NC_002655.2 488643 489713 D Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step; S-adenosylmethionine--tRNA ribosyltransferase-isomerase 488643..489713 Escherichia coli O157:H7 str. EDL933 957360 NP_286145.1 CDS tgt NC_002655.2 489768 490895 D Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); queuine tRNA-ribosyltransferase 489768..490895 Escherichia coli O157:H7 str. EDL933 957361 NP_286146.1 CDS yajC NC_002655.2 490918 491250 D member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex; preprotein translocase subunit YajC 490918..491250 Escherichia coli O157:H7 str. EDL933 957362 NP_286147.1 CDS secD NC_002655.2 491278 493125 D part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; preprotein translocase subunit SecD 491278..493125 Escherichia coli O157:H7 str. EDL933 957363 NP_286148.1 CDS secF NC_002655.2 493136 494107 D forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; preprotein translocase subunit SecF 493136..494107 Escherichia coli O157:H7 str. EDL933 957364 NP_286149.1 CDS Z0509 NC_002655.2 494258 494500 D hypothetical protein 494258..494500 Escherichia coli O157:H7 str. EDL933 957365 NP_286150.1 CDS Z0510 NC_002655.2 494493 494774 D hypothetical protein 494493..494774 Escherichia coli O157:H7 str. EDL933 957367 NP_286151.1 CDS yajD NC_002655.2 494862 495209 D hypothetical protein 494862..495209 Escherichia coli O157:H7 str. EDL933 957368 NP_286152.1 CDS tsx NC_002655.2 495386 496270 R nucleoside channel phage T6/colicin K receptor complement(495386..496270) Escherichia coli O157:H7 str. EDL933 957370 NP_286153.2 CDS yajI NC_002655.2 496569 497108 R hypothetical protein complement(496569..497108) Escherichia coli O157:H7 str. EDL933 957371 NP_286154.1 CDS nrdR NC_002655.2 497259 497708 D transcriptional regulator NrdR 497259..497708 Escherichia coli O157:H7 str. EDL933 957372 NP_286155.1 CDS ribD NC_002655.2 497712 498815 D riboflavin biosynthesis protein which catalyzes the deamination and reduction steps in the riboflavin biosynthesis pathway; catalyzes the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 5-amino-6-(5-phosphoribitylamino)uracil; bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase 497712..498815 Escherichia coli O157:H7 str. EDL933 957373 NP_286156.1 CDS ribH NC_002655.2 498904 499374 D RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase 498904..499374 Escherichia coli O157:H7 str. EDL933 957375 NP_286157.1 CDS nusB NC_002655.2 499394 499813 D Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB 499394..499813 Escherichia coli O157:H7 str. EDL933 957377 NP_286158.1 CDS thiL NC_002655.2 499891 500868 D catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP; thiamine monophosphate kinase 499891..500868 Escherichia coli O157:H7 str. EDL933 957378 NP_286159.1 CDS pgpA NC_002655.2 500846 501361 D hydrolyzes phosphatidylglycerophosphate to produce phosphatidylglycerol and phosphate; phosphatidylglycerophosphatase A 500846..501361 Escherichia coli O157:H7 str. EDL933 957379 NP_286160.1 CDS Z0521 NC_002655.2 501539 503110 R hypothetical protein complement(501539..503110) Escherichia coli O157:H7 str. EDL933 957382 NP_286161.1 CDS yajO NC_002655.2 503341 504315 R NAD(P)H-dependent xylose reductase complement(503341..504315) Escherichia coli O157:H7 str. EDL933 957383 NP_286162.1 CDS dxs NC_002655.2 504370 506232 R catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase complement(504370..506232) Escherichia coli O157:H7 str. EDL933 957384 NP_286163.1 CDS ispA NC_002655.2 506257 507156 R geranyltranstransferase complement(506257..507156) Escherichia coli O157:H7 str. EDL933 957385 NP_286164.1 CDS xseB NC_002655.2 507156 507398 R catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit complement(507156..507398) Escherichia coli O157:H7 str. EDL933 957387 NP_286165.1 CDS yajK NC_002655.2 507604 509052 D Required for the synthesis of the thiazole moiety; thiamine biosynthesis protein ThiI 507604..509052 Escherichia coli O157:H7 str. EDL933 957389 NP_286166.1 CDS thiJ NC_002655.2 509106 509702 R DJ-1 family protein complement(509106..509702) Escherichia coli O157:H7 str. EDL933 957392 NP_286167.1 CDS apbA NC_002655.2 509659 510570 R ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis; 2-dehydropantoate 2-reductase complement(509659..510570) Escherichia coli O157:H7 str. EDL933 957394 NP_286168.2 CDS yajQ NC_002655.2 510738 511229 D nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription; nucleotide-binding protein 510738..511229 Escherichia coli O157:H7 str. EDL933 957395 NP_286169.1 CDS yajR NC_002655.2 511357 512727 R transporter complement(511357..512727) Escherichia coli O157:H7 str. EDL933 957396 NP_286170.1 CDS cyoE NC_002655.2 512870 513760 R converts protoheme IX and farnesyl diphosphate to heme O; protoheme IX farnesyltransferase complement(512870..513760) Escherichia coli O157:H7 str. EDL933 957397 NP_286171.1 CDS cyoD NC_002655.2 513772 514101 R cytochrome o ubiquinol oxidase subunit IV complement(513772..514101) Escherichia coli O157:H7 str. EDL933 957398 NP_286172.1 CDS cyoC NC_002655.2 514101 514715 R cytochrome o ubiquinol oxidase subunit III complement(514101..514715) Escherichia coli O157:H7 str. EDL933 957399 NP_286173.1 CDS cyoB NC_002655.2 514705 516696 R cytochrome o ubiquinol oxidase subunit I complement(514705..516696) Escherichia coli O157:H7 str. EDL933 957400 NP_286174.1 CDS cyoA NC_002655.2 516718 517665 R cytochrome o ubiquinol oxidase subunit II complement(516718..517665) Escherichia coli O157:H7 str. EDL933 957401 NP_286175.1 CDS ampG NC_002655.2 518125 519600 R in Escherichia coli this protein is a permease involved in peptidoglycan recycling; member of major facilitator superfamily; MFS; inner membrane protein; muropeptide transporter complement(518125..519600) Escherichia coli O157:H7 str. EDL933 957402 NP_286176.2 CDS yajG NC_002655.2 519644 520222 R hypothetical protein complement(519644..520222) Escherichia coli O157:H7 str. EDL933 957404 NP_286177.2 CDS bolA NC_002655.2 520527 520844 D positive transcriptional regulator of morphogenetic pathway; controlling several genes involved in oxidative stress, acid stress, heat shock, osmotic shock, and carbon-starvation stress; transcriptional regulator BolA 520527..520844 Escherichia coli O157:H7 str. EDL933 957405 NP_286178.1 CDS tig NC_002655.2 521188 522486 D Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 521188..522486 Escherichia coli O157:H7 str. EDL933 957406 NP_286179.1 CDS clpP NC_002655.2 522731 523354 D hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 522731..523354 Escherichia coli O157:H7 str. EDL933 957407 NP_286180.1 CDS clpX NC_002655.2 523480 524754 D binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX 523480..524754 Escherichia coli O157:H7 str. EDL933 957408 NP_286181.1 CDS lon NC_002655.2 524897 527296 D DNA-binding ATP-dependent protease La 524897..527296 Escherichia coli O157:H7 str. EDL933 957409 NP_286182.1 CDS hupB NC_002655.2 527505 527777 D histone-like DNA-binding protein; transcriptional regulator HU subunit beta 527505..527777 Escherichia coli O157:H7 str. EDL933 957410 NP_286183.1 CDS ybaU NC_002655.2 527969 529840 D peptidyl-prolyl cis-trans isomerase 527969..529840 Escherichia coli O157:H7 str. EDL933 957411 NP_286184.1 CDS ybaV NC_002655.2 529992 530363 D hypothetical protein 529992..530363 Escherichia coli O157:H7 str. EDL933 957412 NP_286185.1 CDS ybaW NC_002655.2 530469 530867 D hypothetical protein 530469..530867 Escherichia coli O157:H7 str. EDL933 957413 NP_286186.1 CDS ybaX NC_002655.2 530919 531614 R YbaX; catalyzes the transformation of GTP to 7-cyano-7-deazaguanine (preQ0), as one of the early reactions of quenosine biosynthesis; quenosine is a modified nucleoside that occurs at the wobble position of GUN anticodons in tRNAs for Asn, Asp, Tyr, and His; queuosine biosynthesis protein QueC complement(530919..531614) Escherichia coli O157:H7 str. EDL933 957415 NP_286187.1 CDS ybaE NC_002655.2 531679 533379 R hypothetical protein complement(531679..533379) Escherichia coli O157:H7 str. EDL933 957416 NP_286188.1 CDS cof NC_002655.2 533467 534297 D hypothetical protein 533467..534297 Escherichia coli O157:H7 str. EDL933 957417 NP_286189.1 CDS ybaO NC_002655.2 534449 534907 D transcriptional regulator 534449..534907 Escherichia coli O157:H7 str. EDL933 957418 NP_286190.1 CDS mdlA NC_002655.2 534937 536709 D multidrug transporter membrane\ATP-binding components 534937..536709 Escherichia coli O157:H7 str. EDL933 957419 NP_286191.1 CDS mdlB NC_002655.2 536702 538483 D multidrug transporter membrane\ATP-binding components 536702..538483 Escherichia coli O157:H7 str. EDL933 957421 NP_286192.1 CDS glnK NC_002655.2 538664 539002 D indirectly regulates nitrogen metabolism; at high nitrogen levels P-II 2 prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II 2 is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; functionally it is equivalent to protein P-II (GlnB), but itsexpression is driven by the presence of uridylyltransferase, nitrogen regulator I, and the absence of ammonia.; nitrogen regulatory protein P-II 2 538664..539002 Escherichia coli O157:H7 str. EDL933 957422 NP_286193.1 CDS amtB NC_002655.2 539032 540318 D ammonium transporter 539032..540318 Escherichia coli O157:H7 str. EDL933 957423 NP_286194.1 CDS tesB NC_002655.2 540367 541227 R acyl-CoA thioesterase complement(540367..541227) Escherichia coli O157:H7 str. EDL933 957424 NP_286195.1 CDS ybaY NC_002655.2 541445 542017 D glycoprotein/polysaccharide metabolism 541445..542017 Escherichia coli O157:H7 str. EDL933 957425 NP_286196.1 CDS ybaZ NC_002655.2 542050 542421 R hypothetical protein complement(542050..542421) Escherichia coli O157:H7 str. EDL933 957427 NP_286197.1 CDS ybaA NC_002655.2 542740 543093 D hypothetical protein 542740..543093 Escherichia coli O157:H7 str. EDL933 957429 NP_286198.1 CDS ylaB NC_002655.2 543135 544691 R hypothetical protein complement(543135..544691) Escherichia coli O157:H7 str. EDL933 957430 NP_286199.1 CDS ylaC NC_002655.2 544849 545358 R hypothetical protein complement(544849..545358) Escherichia coli O157:H7 str. EDL933 957431 NP_286200.1 CDS ylaD NC_002655.2 545435 545986 R maltose O-acetyltransferase complement(545435..545986) Escherichia coli O157:H7 str. EDL933 957433 NP_286201.1 CDS hha NC_002655.2 546158 546376 R with Hns involved in transcriptional regulation of hemolysin; non-specific DNA-binding protein which affects the production of multiple proteins; hemolysin expression-modulating protein complement(546158..546376) Escherichia coli O157:H7 str. EDL933 957434 NP_286202.1 CDS ybaJ NC_002655.2 546402 546776 R hypothetical protein complement(546402..546776) Escherichia coli O157:H7 str. EDL933 957435 NP_286203.1 CDS acrB NC_002655.2 547322 550471 R acridine efflux pump complement(547322..550471) Escherichia coli O157:H7 str. EDL933 957438 NP_286204.1 CDS acrA NC_002655.2 550494 551687 R acridine efflux pump complement(550494..551687) Escherichia coli O157:H7 str. EDL933 957439 NP_286205.1 CDS acrR NC_002655.2 551829 552476 D regulates the acrAB operon which is involved in susceptibility to dephalothin and cephaloridine; DNA-binding transcriptional repressor AcrR 551829..552476 Escherichia coli O157:H7 str. EDL933 957440 NP_286206.1 CDS aefA NC_002655.2 552604 555966 D small mechanosensitive ion channel (MscS) that opens in response to stretch forces in the membrane lipid bilayer; maintains cell turgor through accumulation and release of potassium; large protein class of MscS; potassium efflux protein KefA 552604..555966 Escherichia coli O157:H7 str. EDL933 957441 NP_286207.1 CDS Z0583 NC_002655.2 556005 556169 R hypothetical protein complement(556005..556169) Escherichia coli O157:H7 str. EDL933 957442 NP_286208.1 CDS priC NC_002655.2 556183 556710 R PriC; protein involved in DNA replication; part of the primosome, a protein complex required to restart stalled replication forks; binds the complex formed by PriA, PriB and DNA; PriC-dependent primosome requires a gap to restart DNA replication; stimulates Rep activity at stalled forks; primosomal replication protein N'' complement(556183..556710) Escherichia coli O157:H7 str. EDL933 957443 NP_286209.1 CDS ybaN NC_002655.2 556780 557157 D hypothetical protein 556780..557157 Escherichia coli O157:H7 str. EDL933 957444 NP_286210.1 CDS apt NC_002655.2 557310 557861 D catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase 557310..557861 Escherichia coli O157:H7 str. EDL933 957445 NP_286211.1 CDS dnaX NC_002655.2 557990 559921 D catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau 557990..559921 Escherichia coli O157:H7 str. EDL933 957446 NP_286212.1 CDS ybaB NC_002655.2 559974 560303 D hypothetical protein 559974..560303 Escherichia coli O157:H7 str. EDL933 957447 NP_286213.1 CDS recR NC_002655.2 560303 560908 D involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR 560303..560908 Escherichia coli O157:H7 str. EDL933 957448 NP_286214.1 CDS htpG NC_002655.2 561018 562892 D molecular chaperone; heat shock protein 90 561018..562892 Escherichia coli O157:H7 str. EDL933 957449 NP_286215.1 CDS adk NC_002655.2 563073 563717 D essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 563073..563717 Escherichia coli O157:H7 str. EDL933 957450 NP_286216.1 CDS hemH NC_002655.2 563849 564811 D protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic; ferrochelatase 563849..564811 Escherichia coli O157:H7 str. EDL933 957451 NP_286217.1 CDS ybaC NC_002655.2 564808 565767 R acetyl esterase complement(564808..565767) Escherichia coli O157:H7 str. EDL933 957452 NP_286218.1 CDS gsk NC_002655.2 565919 567223 D inosine-guanosine kinase 565919..567223 Escherichia coli O157:H7 str. EDL933 957453 NP_286219.1 CDS ybaL NC_002655.2 567356 569032 R YbaL; member of the CPA-2 family of antiporters; uncharacterized protein; cation:proton antiport protein complement(567356..569032) Escherichia coli O157:H7 str. EDL933 957454 NP_286220.1 CDS fsr NC_002655.2 569269 570489 R fosmidomycin resistance protein complement(569269..570489) Escherichia coli O157:H7 str. EDL933 957455 NP_286221.1 CDS ushA NC_002655.2 570707 572359 D catalyzes the degradation of periplasmic UDP-glucose to uridine, glucose-1-phosphate and inorganic phosphate; specific for uridine nucleotides; bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic 570707..572359 Escherichia coli O157:H7 str. EDL933 957456 NP_286222.1 CDS ybaK NC_002655.2 572396 572875 R hypothetical protein complement(572396..572875) Escherichia coli O157:H7 str. EDL933 957457 NP_286223.1 CDS ybaP NC_002655.2 573079 573873 R ligase complement(573079..573873) Escherichia coli O157:H7 str. EDL933 957458 NP_286224.1 CDS ybaQ NC_002655.2 573957 574352 D hypothetical protein 573957..574352 Escherichia coli O157:H7 str. EDL933 957459 NP_286225.1 CDS copA NC_002655.2 574567 577071 R copper exporting ATPase complement(574567..577071) Escherichia coli O157:H7 str. EDL933 957460 NP_286226.1 CDS ybaS NC_002655.2 577333 578265 D catalyzes the formation of glutamate from glutamine; glutaminase 577333..578265 Escherichia coli O157:H7 str. EDL933 957462 NP_286227.1 CDS ybaT NC_002655.2 578268 579560 D amino acid/amine transport protein 578268..579560 Escherichia coli O157:H7 str. EDL933 957463 NP_286228.1 CDS Z0608 NC_002655.2 579898 581253 D outer membrane export protein 579898..581253 Escherichia coli O157:H7 str. EDL933 957464 NP_286229.1 CDS Z0609 NC_002655.2 581356 585741 D hypothetical protein 581356..585741 Escherichia coli O157:H7 str. EDL933 957466 NP_286230.1 CDS Z0615 NC_002655.2 585949 601515 D RTX family exoprotein 585949..601515 Escherichia coli O157:H7 str. EDL933 957468 NP_286231.1 CDS Z0634 NC_002655.2 601519 603681 D hypothetical protein 601519..603681 Escherichia coli O157:H7 str. EDL933 957469 NP_286232.1 CDS Z0635 NC_002655.2 603678 604853 D membrane spanning export protein 603678..604853 Escherichia coli O157:H7 str. EDL933 957470 NP_286233.1 CDS ybbI NC_002655.2 604925 605257 D transcriptional regulator 604925..605257 Escherichia coli O157:H7 str. EDL933 957471 NP_286234.1 CDS Z0638 NC_002655.2 605461 605883 R No significant matches; hypothetical protein complement(605461..605883) Escherichia coli O157:H7 str. EDL933 957473 NP_286235.1 CDS Z0639 NC_002655.2 605968 606984 R hypothetical protein complement(605968..606984) Escherichia coli O157:H7 str. EDL933 957474 NP_286236.1 CDS Z0640 NC_002655.2 607351 607713 D No significant matches; hypothetical protein 607351..607713 Escherichia coli O157:H7 str. EDL933 957475 NP_286237.1 CDS ybbJ NC_002655.2 607892 608350 R hypothetical protein complement(607892..608350) Escherichia coli O157:H7 str. EDL933 957476 NP_286238.1 CDS ybbK NC_002655.2 608347 609264 R protease complement(608347..609264) Escherichia coli O157:H7 str. EDL933 957477 NP_286239.1 CDS ybbL NC_002655.2 609410 610087 D ABC transporter ATP-binding protein 609410..610087 Escherichia coli O157:H7 str. EDL933 957478 NP_286240.1 CDS ybbM NC_002655.2 610047 610853 D metal resistance protein 610047..610853 Escherichia coli O157:H7 str. EDL933 957479 NP_286241.1 CDS ybbN NC_002655.2 610916 611806 R thioredoxin-like protein complement(610916..611806) Escherichia coli O157:H7 str. EDL933 957481 NP_286242.1 CDS ybbO NC_002655.2 611831 612640 R short chain dehydrogenase complement(611831..612640) Escherichia coli O157:H7 str. EDL933 957483 NP_286243.1 CDS tesA NC_002655.2 612630 613256 R multifunctional acyl-CoA thioesterase I/protease I/lysophospholipase L1 complement(612630..613256) Escherichia coli O157:H7 str. EDL933 957484 NP_286244.1 CDS ybbA NC_002655.2 613224 613910 D ABC transporter ATP-binding protein 613224..613910 Escherichia coli O157:H7 str. EDL933 957485 NP_286245.1 CDS ybbP NC_002655.2 613907 616321 D oxidoreductase 613907..616321 Escherichia coli O157:H7 str. EDL933 957486 NP_286246.1 CDS Z0651 NC_002655.2 616751 620947 D hypothetical protein 616751..620947 Escherichia coli O157:H7 str. EDL933 957487 NP_286247.1 CDS ybbD NC_002655.2 620928 621188 D hypothetical protein 620928..621188 Escherichia coli O157:H7 str. EDL933 957488 NP_286248.1 CDS Z0654 NC_002655.2 621227 621376 D hypothetical protein 621227..621376 Escherichia coli O157:H7 str. EDL933 957489 NP_286249.1 CDS Z0655 NC_002655.2 621371 621523 R No significant matches; hypothetical protein complement(621371..621523) Escherichia coli O157:H7 str. EDL933 957491 NP_286250.1 CDS Z0656 NC_002655.2 621932 622339 R hypothetical protein complement(621932..622339) Escherichia coli O157:H7 str. EDL933 957492 NP_286251.1 CDS ybbB NC_002655.2 622419 623513 R catalyzes the selenophosphate-dependent transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA; tRNA 2-selenouridine synthase complement(622419..623513) Escherichia coli O157:H7 str. EDL933 957493 NP_286252.1 CDS ybbS NC_002655.2 623582 624508 R activator of the allDC-ylbA operon involved in allantoin utilization; DNA-binding transcriptional activator AllS complement(623582..624508) Escherichia coli O157:H7 str. EDL933 957494 NP_286253.1 CDS ybbT NC_002655.2 624738 625220 D catalyzes the formation of glyoxylate from (S)-ureidoglycolate; ureidoglycolate hydrolase 624738..625220 Escherichia coli O157:H7 str. EDL933 957495 NP_286254.1 CDS ybbU NC_002655.2 625298 626113 D regulates operons involved in the utilization of allantoin; DNA-binding transcriptional repressor AllR 625298..626113 Escherichia coli O157:H7 str. EDL933 957496 NP_286255.1 CDS gcl NC_002655.2 626203 627984 D catalyzes the formation of 2-hydroxy-3-oxopropanoate (tartronate semialdehyde) from two molecules of glyoxylate; glyoxylate carboligase 626203..627984 Escherichia coli O157:H7 str. EDL933 957497 NP_286256.1 CDS gip NC_002655.2 627997 628773 D hydroxypyruvate isomerase 627997..628773 Escherichia coli O157:H7 str. EDL933 957498 NP_286257.1 CDS ybbQ NC_002655.2 628874 629752 D oxidoreductase 628874..629752 Escherichia coli O157:H7 str. EDL933 957501 NP_286258.1 CDS ybbV NC_002655.2 629784 630062 D hypothetical protein 629784..630062 Escherichia coli O157:H7 str. EDL933 957502 NP_286259.1 CDS Z0665 NC_002655.2 629921 631312 D allantoin permease 629921..631312 Escherichia coli O157:H7 str. EDL933 957507 NP_286260.1 CDS Z0666 NC_002655.2 631349 632239 D Plays a crucial role on both purine and pyrimidine metabolism; allantoinase 631349..632239 Escherichia coli O157:H7 str. EDL933 957508 NP_286261.1 CDS Z0667 NC_002655.2 632246 632710 D hypothetical protein 632246..632710 Escherichia coli O157:H7 str. EDL933 957509 NP_286262.1 CDS ybbY NC_002655.2 632761 634068 D purine permease YbbY 632761..634068 Escherichia coli O157:H7 str. EDL933 957511 NP_286263.1 CDS ybbZ NC_002655.2 634090 635235 D glycerate kinase 634090..635235 Escherichia coli O157:H7 str. EDL933 957512 NP_286264.1 CDS ylbA NC_002655.2 635463 636248 R hypothetical protein complement(635463..636248) Escherichia coli O157:H7 str. EDL933 957514 NP_286265.1 CDS ylbB NC_002655.2 636259 637494 R allantoate amidohydrolase and N-carbamoyl-L-amino acid amidohydrolase are very similar; the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia; carbamoyl amidohydrolase from Bacillus sp. converts N-carbamoyl amino acids to amino acids, ammonia, and carbon dioxide; allantoate amidohydrolase complement(636259..637494) Escherichia coli O157:H7 str. EDL933 957515 NP_286266.1 CDS ylbC NC_002655.2 637516 638565 R malate dehydrogenase complement(637516..638565) Escherichia coli O157:H7 str. EDL933 957518 NP_286267.1 CDS fdrA NC_002655.2 638882 640549 D multicopy suppressor of dominant negative ftsH mutations; membrane protein FdrA 638882..640549 Escherichia coli O157:H7 str. EDL933 957519 NP_286268.1 CDS ylbE NC_002655.2 640817 641818 D hypothetical protein 640817..641818 Escherichia coli O157:H7 str. EDL933 957521 NP_286269.1 CDS ylbF NC_002655.2 641829 642644 D carboxylase 641829..642644 Escherichia coli O157:H7 str. EDL933 957522 NP_286270.1 CDS arcC NC_002655.2 642641 643534 D forms a homodimer; may be used to synthesize carbomyl phosphate from ATP and carbamate; carbamate kinase 642641..643534 Escherichia coli O157:H7 str. EDL933 957524 NP_286271.1 CDS purK NC_002655.2 643673 644740 R With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit complement(643673..644740) Escherichia coli O157:H7 str. EDL933 957525 NP_286272.1 CDS purE NC_002655.2 644737 645246 R Catalyzes a step in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase catalytic subunit complement(644737..645246) Escherichia coli O157:H7 str. EDL933 957530 NP_286273.1 CDS ybbF NC_002655.2 645364 646086 R catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine; UDP-2,3-diacylglucosamine hydrolase complement(645364..646086) Escherichia coli O157:H7 str. EDL933 957532 NP_286274.1 CDS ppiB NC_002655.2 646089 646583 R peptidyl-prolyl cis-trans isomerase B complement(646089..646583) Escherichia coli O157:H7 str. EDL933 957533 NP_286275.1 CDS cysS NC_002655.2 646757 648142 D catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 646757..648142 Escherichia coli O157:H7 str. EDL933 957534 NP_286276.1 CDS ybcI NC_002655.2 648178 648699 R hypothetical protein complement(648178..648699) Escherichia coli O157:H7 str. EDL933 957535 NP_286277.2 CDS ybcJ NC_002655.2 648807 649019 R hypothetical protein complement(648807..649019) Escherichia coli O157:H7 str. EDL933 957536 NP_286278.1 CDS folD NC_002655.2 649021 649887 R catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase complement(649021..649887) Escherichia coli O157:H7 str. EDL933 957537 NP_286279.1 CDS sfmA NC_002655.2 650325 650900 D fimbrial-like protein 650325..650900 Escherichia coli O157:H7 str. EDL933 957538 NP_286280.1 CDS sfmC NC_002655.2 651120 651812 D chaperone 651120..651812 Escherichia coli O157:H7 str. EDL933 957539 NP_286281.1 CDS sfmD NC_002655.2 651843 654452 D hypothetical protein 651843..654452 Escherichia coli O157:H7 str. EDL933 957540 NP_286282.1 CDS sfmH NC_002655.2 654495 655472 D fimbrial asembly protein 654495..655472 Escherichia coli O157:H7 str. EDL933 957543 NP_286283.1 CDS sfmF NC_002655.2 655483 655998 D fimbrial protein 655483..655998 Escherichia coli O157:H7 str. EDL933 957544 NP_286284.1 CDS fimZ NC_002655.2 656001 656696 R activates the production of the major fimbrae protein FimA; transcriptional regulator FimZ complement(656001..656696) Escherichia coli O157:H7 str. EDL933 957547 NP_286285.1 CDS envY NC_002655.2 656998 657759 R envelope protein; thermoregulation of porin biosynthesis complement(656998..657759) Escherichia coli O157:H7 str. EDL933 957551 NP_286286.1 CDS ybcH NC_002655.2 657942 658832 R hypothetical protein complement(657942..658832) Escherichia coli O157:H7 str. EDL933 957552 NP_286287.1 CDS nfrA NC_002655.2 658833 661805 R bacteriophage N4 receptor, outer membrane subunit complement(658833..661805) Escherichia coli O157:H7 str. EDL933 957554 NP_286288.1 CDS nfrB NC_002655.2 661792 664029 R bacteriophage N4 adsorption protein B complement(661792..664029) Escherichia coli O157:H7 str. EDL933 957558 NP_286289.1 CDS Z0700 NC_002655.2 664295 665431 R receptor complement(664295..665431) Escherichia coli O157:H7 str. EDL933 957559 NP_286290.1 CDS Z0701 NC_002655.2 665646 665867 R No significant matches; hypothetical protein complement(665646..665867) Escherichia coli O157:H7 str. EDL933 957560 NP_286291.1 CDS Z0702 NC_002655.2 665894 667228 R hypothetical protein complement(665894..667228) Escherichia coli O157:H7 str. EDL933 957562 NP_286292.1 CDS Z0705 NC_002655.2 667823 672760 R hypothetical protein complement(667823..672760) Escherichia coli O157:H7 str. EDL933 957563 NP_286293.1 CDS Z0706 NC_002655.2 672780 673241 R No significant matches; hypothetical protein complement(672780..673241) Escherichia coli O157:H7 str. EDL933 957564 NP_286294.1 CDS Z0707 NC_002655.2 673269 675170 R hypothetical protein complement(673269..675170) Escherichia coli O157:H7 str. EDL933 957565 NP_286295.1 CDS ybcZ NC_002655.2 675764 677212 R sensor kinase CusS complement(675764..677212) Escherichia coli O157:H7 str. EDL933 957566 NP_286296.1 CDS ylcA NC_002655.2 677202 677885 R response regulator in two-component regulatory system with CusS; regulates the copper efflux system; DNA-binding transcriptional activator CusR complement(677202..677885) Escherichia coli O157:H7 str. EDL933 957567 NP_286297.1 CDS ylcB NC_002655.2 678042 679424 D with CusA, CusB and CusF is part of a cation efflux system that mediates resistance to copper and silver; copper/silver efflux system outer membrane protein CusC 678042..679424 Escherichia coli O157:H7 str. EDL933 957569 NP_286298.1 CDS ylcC NC_002655.2 679448 679780 D copper-binding protein 679448..679780 Escherichia coli O157:H7 str. EDL933 957570 NP_286299.1 CDS ylcD NC_002655.2 679796 681019 D with CusA, CusC and CusF is part of a cation efflux system that mediates resistance to copper and silver; copper/silver efflux system membrane fusion protein CusB 679796..681019 Escherichia coli O157:H7 str. EDL933 957571 NP_286300.1 CDS ybdE NC_002655.2 681031 684168 D inner membrane component for iron transport 681031..684168 Escherichia coli O157:H7 str. EDL933 957572 NP_286301.1 CDS pheP NC_002655.2 684270 685646 D phenylalanine transporter 684270..685646 Escherichia coli O157:H7 str. EDL933 957574 NP_286302.1 CDS ybdG NC_002655.2 685714 686961 R transport complement(685714..686961) Escherichia coli O157:H7 str. EDL933 957575 NP_286303.1 CDS nfnB NC_002655.2 687069 687722 R catalyzes the reduction of nitroaromatic compounds such as nitrofurazone, quinones and the anti-tumor agent CB1954; NAD(P)H-dependent; oxygen insensitive; dihydropteridine reductase complement(687069..687722) Escherichia coli O157:H7 str. EDL933 957577 NP_286304.1 CDS ybdF NC_002655.2 687816 688184 R hypothetical protein complement(687816..688184) Escherichia coli O157:H7 str. EDL933 957578 NP_286305.1 CDS ybdJ NC_002655.2 688249 688497 R hypothetical protein complement(688249..688497) Escherichia coli O157:H7 str. EDL933 957580 NP_286306.1 CDS ybdK NC_002655.2 688563 689681 R ATP-dependent; carboxylate-amine ligase with weak glutamate--cysteine ligase activity; carboxylate-amine ligase complement(688563..689681) Escherichia coli O157:H7 str. EDL933 957581 NP_286307.1 CDS Z0721 NC_002655.2 689976 690272 D hypothetical protein 689976..690272 Escherichia coli O157:H7 str. EDL933 957586 NP_286308.1 CDS Z0722 NC_002655.2 690524 690775 D hypothetical protein 690524..690775 Escherichia coli O157:H7 str. EDL933 957587 NP_286309.1 CDS entD NC_002655.2 690897 691526 R phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex complement(690897..691526) Escherichia coli O157:H7 str. EDL933 957588 NP_286310.1 CDS fepA NC_002655.2 691692 693932 R Fep; Cbt; Cbr; FeuB; FepA; PfeA; IroN; BfeA; outer membrane receptor of ferric enterobactin and colicins B and D; interacts with the TonB-ExbBD complex which catalyzes the translocation of the siderophore to the periplasmic space; outer membrane receptor FepA complement(691692..693932) Escherichia coli O157:H7 str. EDL933 957590 NP_286311.1 CDS fes NC_002655.2 694253 695377 D enterobactin/ferric enterobactin esterase 694253..695377 Escherichia coli O157:H7 str. EDL933 957591 NP_286312.1 CDS Z0726 NC_002655.2 695380 695598 D No significant matches; hypothetical protein 695380..695598 Escherichia coli O157:H7 str. EDL933 957592 NP_286313.1 CDS entF NC_002655.2 695595 699476 D with EntB, EntD, and EntE forms the multienzyme complex enterobactin synthase; EntF is the serine activating enzyme which catalyzes the formation of the amide and ester bonds of the cyclic enterobactin; enterobactin synthase subunit F 695595..699476 Escherichia coli O157:H7 str. EDL933 957595 NP_286314.1 CDS fepE NC_002655.2 699692 700825 D part of the ferric enterobactin transport system; necessary for enetrobactin uptake; ferric enterobactin transport protein FepE 699692..700825 Escherichia coli O157:H7 str. EDL933 957597 NP_286315.1 CDS fepC NC_002655.2 700822 701637 R with FepBDE is involved in the transport of ferric enterobactin; iron-enterobactin transporter ATP-binding protein complement(700822..701637) Escherichia coli O157:H7 str. EDL933 957599 NP_286316.1 CDS fepG NC_002655.2 701634 702626 R with FepBCD is involved in the transport of ferric enterobactin; iron-enterobactin transporter permease complement(701634..702626) Escherichia coli O157:H7 str. EDL933 957600 NP_286317.1 CDS fepD NC_002655.2 702623 703627 R with FepBCG is involved in the transport of ferric enterobactin; iron-enterobactin transporter membrane protein complement(702623..703627) Escherichia coli O157:H7 str. EDL933 957601 NP_286318.1 CDS ybdA NC_002655.2 703738 704988 D protein p43; inner membrane protein that exports enterobactin to the periplasmic space; member of the major facilitator superfamily (MFS) of transporters; enterobactin exporter EntS 703738..704988 Escherichia coli O157:H7 str. EDL933 957603 NP_286319.1 CDS fepB NC_002655.2 704992 705948 R with FepCDG is involved in the transport of ferric enterobactin; iron-enterobactin transporter periplasmic binding protein complement(704992..705948) Escherichia coli O157:H7 str. EDL933 957604 NP_286320.1 CDS entC NC_002655.2 706137 707312 D synthesizes isochorismate acid from chorismate; isochorismate synthase 706137..707312 Escherichia coli O157:H7 str. EDL933 957607 NP_286321.1 CDS entE NC_002655.2 707322 708932 D bifunctional 2,3-dihydroxybenzoate-AMP ligase/S-dihydroxybenzoyltransferase; activates the carboxylate group of 2,3-dihydroxy-benzoate forming (2,3-dihydroxybenzoyl)adenylate then catalyzes the acylation of holo-entB with 2,3-dihydroxy-benzoate adenylate; enterobactin synthase subunit E 707322..708932 Escherichia coli O157:H7 str. EDL933 957608 NP_286322.1 CDS entB NC_002655.2 708946 709803 D 2,3-dihydro-2,3-dihydroxybenzoate synthetase 708946..709803 Escherichia coli O157:H7 str. EDL933 957609 NP_286323.1 CDS entA NC_002655.2 709803 710549 D catalyzes the formation of 2,3-dihydroxybenzoate from 2,3-dihydro-2,3-dihydroxybenzoate; involved in the biosynthesis of siderophores, enterobactin, bacillibactin or vibriobactin; 2,3-dihydroxybenzoate-2,3-dehydrogenase 709803..710549 Escherichia coli O157:H7 str. EDL933 957611 NP_286324.1 CDS ybdB NC_002655.2 710552 710965 D hypothetical protein 710552..710965 Escherichia coli O157:H7 str. EDL933 957613 NP_286325.1 CDS cstA NC_002655.2 711146 713251 D carbon starvation protein 711146..713251 Escherichia coli O157:H7 str. EDL933 957614 NP_286326.1 CDS ybdH NC_002655.2 713640 714728 R member of the iron-containing alcohol dehydrogenase; unknown function; hypothetical protein complement(713640..714728) Escherichia coli O157:H7 str. EDL933 957615 NP_286327.1 CDS ybdL NC_002655.2 714837 715997 D catalyzes the transfer of an amino moiety; aminotransferase 714837..715997 Escherichia coli O157:H7 str. EDL933 957617 NP_286328.1 CDS ybdM NC_002655.2 715998 716627 R hypothetical protein complement(715998..716627) Escherichia coli O157:H7 str. EDL933 957619 NP_286329.1 CDS ybdN NC_002655.2 716600 717820 R hypothetical protein complement(716600..717820) Escherichia coli O157:H7 str. EDL933 957620 NP_286330.1 CDS ybdO NC_002655.2 717967 718869 R LysR family transcriptional regulator complement(717967..718869) Escherichia coli O157:H7 str. EDL933 957621 NP_286331.2 CDS dsbG NC_002655.2 719079 719825 R Involved in disulfide bond formation; disulfide isomerase/thiol-disulfide oxidase complement(719079..719825) Escherichia coli O157:H7 str. EDL933 957624 NP_286332.1 CDS ahpC NC_002655.2 720197 720760 D with AhpF catalyzes the conversion of alkyl hydroperoxides to their corresponding alcohols; AhpC reduced the hydroperoxide substrate; alkyl hydroperoxide reductase 720197..720760 Escherichia coli O157:H7 str. EDL933 957626 NP_286333.1 CDS ahpF NC_002655.2 720859 722454 D alkyl hydroperoxide reductase 720859..722454 Escherichia coli O157:H7 str. EDL933 957628 NP_286334.1 CDS ybdQ NC_002655.2 722575 723003 R hypothetical protein complement(722575..723003) Escherichia coli O157:H7 str. EDL933 957630 NP_286335.1 CDS ybdR NC_002655.2 723224 724462 D oxidoreductase 723224..724462 Escherichia coli O157:H7 str. EDL933 957631 NP_286336.1 CDS Z0753 NC_002655.2 724543 725004 D hypothetical protein 724543..725004 Escherichia coli O157:H7 str. EDL933 957632 NP_286337.1 CDS rnk NC_002655.2 724693 725103 R Regulates the synthesis of nucleoside triphosphates for nucleic acid synthesis, CTP for lipid synthesis, and GTP for protein elongation; nucleoside diphosphate kinase regulator complement(724693..725103) Escherichia coli O157:H7 str. EDL933 957633 NP_286338.1 CDS rna NC_002655.2 725333 726139 R ribonuclease I complement(725333..726139) Escherichia coli O157:H7 str. EDL933 957635 NP_286339.1 CDS ybdS NC_002655.2 726253 727716 R hypothetical protein complement(726253..727716) Escherichia coli O157:H7 str. EDL933 957636 NP_286340.1 CDS citG NC_002655.2 727767 728645 R catalyzes the formation of 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA from ATP and 3-dephospho-CoA; triphosphoribosyl-dephospho-CoA synthase complement(727767..728645) Escherichia coli O157:H7 str. EDL933 957638 NP_286341.1 CDS citX NC_002655.2 728620 729171 R 2'-(5''-phosphoribosyl)-3'-dephospho-CoA transferase; holo-citrate lyase synthase; CitG forms the prosthetic group precursor 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA which is then transferred to apo-ACP by CitX to produce holo-ACP and pyrophosphate; 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase complement(728620..729171) Escherichia coli O157:H7 str. EDL933 957639 NP_286342.1 CDS citF NC_002655.2 729175 730707 R citrate lyase subunit alpha complement(729175..730707) Escherichia coli O157:H7 str. EDL933 957640 NP_286343.1 CDS citE NC_002655.2 730718 731641 R citrate lyase subunit beta complement(730718..731641) Escherichia coli O157:H7 str. EDL933 957644 NP_286344.1 CDS citD NC_002655.2 731623 731919 R acyl carrier protein; with CitE and CitF catalyzes the formation of oxaloacetate from citrate; citrate lyase subunit gamma complement(731623..731919) Escherichia coli O157:H7 str. EDL933 957645 NP_286345.1 CDS citC NC_002655.2 731934 733079 R citrate lyase synthetase complement(731934..733079) Escherichia coli O157:H7 str. EDL933 957647 NP_286346.1 CDS citA NC_002655.2 733372 735030 D sensor-type protein 733372..735030 Escherichia coli O157:H7 str. EDL933 957648 NP_286347.1 CDS dpiA NC_002655.2 734999 735679 D regulates the expression of citAB in citrate fermentation; two-component response regulator DpiA 734999..735679 Escherichia coli O157:H7 str. EDL933 957649 NP_286348.1 CDS dcuC NC_002655.2 735720 737105 R responsible for the transport of C4-dicarboxylates during anaerobic growth; C4-dicarboxylate transporter DcuC complement(735720..737105) Escherichia coli O157:H7 str. EDL933 957650 NP_286349.1 CDS pagP NC_002655.2 737694 738254 D catalyzes the transfer of palmitate to lipid A; palmitoyl transferase 737694..738254 Escherichia coli O157:H7 str. EDL933 957652 NP_286350.1 CDS cspE NC_002655.2 738429 738638 D member of the CspA family; constitutively expressed RNA/ssDNA-binding protein; functions in helping cells adapt to low temperature; aids nucleic acid melting; participates in gene regulation; can act as a transcription antiterminator; cold shock protein CspE 738429..738638 Escherichia coli O157:H7 str. EDL933 957654 NP_286351.1 CDS ccrB NC_002655.2 738691 739074 R may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB complement(738691..739074) Escherichia coli O157:H7 str. EDL933 957655 NP_286352.1 CDS ybeM NC_002655.2 739392 739955 D hypothetical protein 739392..739955 Escherichia coli O157:H7 str. EDL933 957658 NP_286353.1 CDS tatE NC_002655.2 740084 740287 D TatE; similar to TatA and found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin arginine translocase E 740084..740287 Escherichia coli O157:H7 str. EDL933 957659 NP_286354.1 CDS lipA NC_002655.2 740388 741353 R catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group; lipoyl synthase complement(740388..741353) Escherichia coli O157:H7 str. EDL933 957660 NP_286355.1 CDS ybeF NC_002655.2 741562 742362 R DNA-binding transcriptional regulator complement(741562..742362) Escherichia coli O157:H7 str. EDL933 957661 NP_286356.2 CDS lipB NC_002655.2 742775 743416 R lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein; lipoate-protein ligase B complement(742775..743416) Escherichia coli O157:H7 str. EDL933 957662 NP_286357.1 CDS ybeD NC_002655.2 743517 743780 R hypothetical protein complement(743517..743780) Escherichia coli O157:H7 str. EDL933 957666 NP_286358.1 CDS dacA NC_002655.2 743890 745101 R penicillin-binding protein 5; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; D-alanyl-D-alanine carboxypeptidase complement(743890..745101) Escherichia coli O157:H7 str. EDL933 957671 NP_286359.1 CDS rlpA NC_002655.2 745241 746329 R rare lipoprotein A complement(745241..746329) Escherichia coli O157:H7 str. EDL933 957673 NP_286360.1 CDS mrdB NC_002655.2 746340 747452 R cell wall shape-determining protein complement(746340..747452) Escherichia coli O157:H7 str. EDL933 957677 NP_286361.1 CDS mrdA NC_002655.2 747455 749356 R penicillin-binding protein 2 complement(747455..749356) Escherichia coli O157:H7 str. EDL933 957678 NP_286362.1 CDS ybeA NC_002655.2 749387 749854 R SPOUT methyltransferase; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA; rRNA large subunit methyltransferase complement(749387..749854) Escherichia coli O157:H7 str. EDL933 957681 NP_286363.1 CDS ybeB NC_002655.2 749858 750067 R hypothetical protein complement(749858..750067) Escherichia coli O157:H7 str. EDL933 957683 NP_286364.1 CDS phpB NC_002655.2 750435 751046 R alpha-ribazole-5'-phosphate phosphatase complement(750435..751046) Escherichia coli O157:H7 str. EDL933 957685 NP_286365.1 CDS nadD NC_002655.2 751070 751711 R transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria; nicotinic acid mononucleotide adenylyltransferase complement(751070..751711) Escherichia coli O157:H7 str. EDL933 957686 NP_286366.1 CDS holA NC_002655.2 751713 752744 R required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA; DNA polymerase III subunit delta complement(751713..752744) Escherichia coli O157:H7 str. EDL933 957687 NP_286367.1 CDS rlpB NC_002655.2 752744 753325 R rare lipoprotein B; involved in the assembly of LPS in the outer membrane; LPS-assembly lipoprotein RlpB complement(752744..753325) Escherichia coli O157:H7 str. EDL933 957688 NP_286368.1 CDS leuS NC_002655.2 753340 755922 R leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase complement(753340..755922) Escherichia coli O157:H7 str. EDL933 957690 NP_286369.1 CDS ybeL NC_002655.2 756158 756640 D hypothetical protein 756158..756640 Escherichia coli O157:H7 str. EDL933 957694 NP_286370.1 CDS ybeQ NC_002655.2 756710 757297 R hypothetical protein complement(756710..757297) Escherichia coli O157:H7 str. EDL933 957695 NP_286371.1 CDS Z0793 NC_002655.2 757532 757693 R hypothetical protein complement(757532..757693) Escherichia coli O157:H7 str. EDL933 957697 NP_286372.1 CDS ybeR NC_002655.2 757852 758559 D hypothetical protein 757852..758559 Escherichia coli O157:H7 str. EDL933 957701 NP_286373.1 CDS ybeS NC_002655.2 758556 759983 D enzyme of polynucleotide modification 758556..759983 Escherichia coli O157:H7 str. EDL933 957703 NP_286374.1 CDS ybeT NC_002655.2 759993 760547 R hypothetical protein complement(759993..760547) Escherichia coli O157:H7 str. EDL933 957705 NP_286375.1 CDS ybeU NC_002655.2 760649 761356 D tRNA ligase 760649..761356 Escherichia coli O157:H7 str. EDL933 957706 NP_286376.1 CDS ybeW NC_002655.2 762864 764534 R molecular chaperone DnaK complement(762864..764534) Escherichia coli O157:H7 str. EDL933 957707 NP_286377.1 CDS rihA NC_002655.2 764618 765553 R Hydrolyzes with equal efficiency cytidine or uridine to ribose and cytosine or uracil, respectively; pyrimidine-specific; ribonucleoside hydrolase 1 complement(764618..765553) Escherichia coli O157:H7 str. EDL933 957708 NP_286378.1 CDS gltL NC_002655.2 765671 766396 R glutamate/aspartate ABC transporter ATP-binding protein complement(765671..766396) Escherichia coli O157:H7 str. EDL933 957712 NP_286379.1 CDS gltK NC_002655.2 766396 767070 R glutamate/aspartate transport system permease complement(766396..767070) Escherichia coli O157:H7 str. EDL933 957713 NP_286380.1 CDS gltJ NC_002655.2 767070 767810 R glutamate/aspartate transport system permease complement(767070..767810) Escherichia coli O157:H7 str. EDL933 957714 NP_286381.1 CDS ybeJ NC_002655.2 767980 768888 R glutamate and aspartate transporter subunit complement(767980..768888) Escherichia coli O157:H7 str. EDL933 957715 NP_286382.1 CDS lnt NC_002655.2 769285 770823 R Transfers the fatty acyl group on membrane lipoproteins; apolipoprotein N-acyltransferase complement(769285..770823) Escherichia coli O157:H7 str. EDL933 957716 NP_286383.1 CDS ybeX NC_002655.2 770848 771726 R transporter complement(770848..771726) Escherichia coli O157:H7 str. EDL933 957717 NP_286384.1 CDS ybeY NC_002655.2 771816 772283 R metalloprotease complement(771816..772283) Escherichia coli O157:H7 str. EDL933 957719 NP_286385.1 CDS ybeZ NC_002655.2 772280 773359 R ATP-binding protein in pho regulon complement(772280..773359) Escherichia coli O157:H7 str. EDL933 957720 NP_286386.1 CDS yleA NC_002655.2 773473 774897 R catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A); (dimethylallyl)adenosine tRNA methylthiotransferase complement(773473..774897) Escherichia coli O157:H7 str. EDL933 957722 NP_286387.1 CDS ubiF NC_002655.2 775043 776218 D catalyzes the formation of 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol from 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol; functions in the biosynthesis of ubiquinone or coenzyme Q; 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase 775043..776218 Escherichia coli O157:H7 str. EDL933 957724 NP_286388.1 CDS asnB NC_002655.2 777457 779121 R functions in asparagine biosynthesis; converts glutamine, aspartate, ATP, and water to glutamate, asparagine, pyrophosphate and AMP; asparagine synthetase B complement(777457..779121) Escherichia coli O157:H7 str. EDL933 957740 NP_286389.1 CDS nagD NC_002655.2 779378 780130 R UMP phosphatase complement(779378..780130) Escherichia coli O157:H7 str. EDL933 957741 NP_286390.1 CDS nagC NC_002655.2 780178 781398 R transcriptional repressor of nag (N-acetylglucosamine) operon complement(780178..781398) Escherichia coli O157:H7 str. EDL933 957745 NP_286391.1 CDS nagA NC_002655.2 781407 782555 R catalyzes the formation of glucosamine 6-phosphate from N-acetylglucosamine 6-phosphate; N-acetylglucosamine-6-phosphate deacetylase complement(781407..782555) Escherichia coli O157:H7 str. EDL933 957746 NP_286392.1 CDS nagB NC_002655.2 782615 783415 R catalyzes the reversible formation of fructose 6-phosphate from glucosamine 6-phosphate; glucosamine-6-phosphate deaminase complement(782615..783415) Escherichia coli O157:H7 str. EDL933 957748 NP_286393.1 CDS nagE NC_002655.2 783748 785694 D phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system N-acetyl glucosamine specific transporter subunit IIABC 783748..785694 Escherichia coli O157:H7 str. EDL933 957751 NP_286394.1 CDS glnS NC_002655.2 785897 787561 D catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; glutaminyl-tRNA synthetase 785897..787561 Escherichia coli O157:H7 str. EDL933 957752 NP_286395.1 CDS Z0828 NC_002655.2 788140 788619 D hypothetical protein 788140..788619 Escherichia coli O157:H7 str. EDL933 957754 NP_286396.1 CDS ybfM NC_002655.2 788574 789545 D hypothetical protein 788574..789545 Escherichia coli O157:H7 str. EDL933 957756 NP_286397.1 CDS ybfN NC_002655.2 789595 789921 D hypothetical protein 789595..789921 Escherichia coli O157:H7 str. EDL933 957757 NP_286398.1 CDS fur NC_002655.2 790005 790451 R negatively regulates a number of operons that encode enzymes involved in iron transport; activated by manganese; forms a homodimer; ferric uptake regulator complement(790005..790451) Escherichia coli O157:H7 str. EDL933 957758 NP_286399.1 CDS fldA NC_002655.2 790742 791272 R An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin FldA complement(790742..791272) Escherichia coli O157:H7 str. EDL933 957759 NP_286400.1 CDS ybfE NC_002655.2 791412 791774 R LexA regulated protein complement(791412..791774) Escherichia coli O157:H7 str. EDL933 957760 NP_286401.1 CDS ybfF NC_002655.2 791845 792609 R hypothetical protein complement(791845..792609) Escherichia coli O157:H7 str. EDL933 957763 NP_286402.1 CDS seqA NC_002655.2 792794 793339 D negative modulator of the initiation of chromosome replication; replication initiation regulator SeqA 792794..793339 Escherichia coli O157:H7 str. EDL933 957765 NP_286403.1 CDS pgm NC_002655.2 793365 795005 D catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate; phosphoglucomutase 793365..795005 Escherichia coli O157:H7 str. EDL933 957767 NP_286404.1 CDS potE NC_002655.2 795062 796381 R catalyzes the uptake of putrescine via a proton symport mechanism, as well as the efflux of putrescine by a putrescine/ornithine antiport system; putrescine transporter complement(795062..796381) Escherichia coli O157:H7 str. EDL933 957769 NP_286405.1 CDS speF NC_002655.2 796378 798576 R ornithine decarboxylase complement(796378..798576) Escherichia coli O157:H7 str. EDL933 957771 NP_286406.1 CDS Z0840 NC_002655.2 799110 799244 D No significant matches; hypothetical protein 799110..799244 Escherichia coli O157:H7 str. EDL933 957773 NP_286407.1 CDS kdpE NC_002655.2 799266 799943 R response regulator in two-component regulatory system with KdpD; regulates the kdp operon involved in potassium transport; DNA-binding transcriptional activator KdpE complement(799266..799943) Escherichia coli O157:H7 str. EDL933 957774 NP_286408.1 CDS kdpD NC_002655.2 799940 802624 R sensory histidine kinase in two-component regulatory system with KdpE; signal sensing protein; sensor protein KdpD complement(799940..802624) Escherichia coli O157:H7 str. EDL933 957776 NP_286409.1 CDS kdpC NC_002655.2 802617 803189 R One of the components of the high-affinity ATP-driven potassium transport (or KDP)system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex; potassium-transporting ATPase subunit C complement(802617..803189) Escherichia coli O157:H7 str. EDL933 957777 NP_286410.1 CDS kdpB NC_002655.2 803198 805246 R One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit B complement(803198..805246) Escherichia coli O157:H7 str. EDL933 957779 NP_286411.1 CDS kdpA NC_002655.2 805269 806942 R catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit A complement(805269..806942) Escherichia coli O157:H7 str. EDL933 957781 NP_286412.1 CDS ybfA NC_002655.2 807344 807550 D hypothetical protein 807344..807550 Escherichia coli O157:H7 str. EDL933 957782 NP_286413.1 CDS rhsC NC_002655.2 807792 811985 D rhsC protein in rhs element, interrupted 807792..811985 Escherichia coli O157:H7 str. EDL933 957783 NP_286415.1 CDS ybfB NC_002655.2 811985 812311 D hypothetical protein 811985..812311 Escherichia coli O157:H7 str. EDL933 957785 NP_286416.1 CDS Z0851 NC_002655.2 812675 813862 D hypothetical protein 812675..813862 Escherichia coli O157:H7 str. EDL933 957786 NP_286417.1 CDS ybfC NC_002655.2 813887 814429 D hypothetical protein 813887..814429 Escherichia coli O157:H7 str. EDL933 957787 NP_286418.1 CDS Z0855 NC_002655.2 815446 815535 D No significant matches; hypothetical protein 815446..815535 Escherichia coli O157:H7 str. EDL933 957788 NP_286420.1 CDS Z0857 NC_002655.2 816079 817152 D receptor 816079..817152 Escherichia coli O157:H7 str. EDL933 957795 NP_286422.1 CDS ybgA NC_002655.2 817301 817810 D hypothetical protein 817301..817810 Escherichia coli O157:H7 str. EDL933 957797 NP_286423.1 CDS phrB NC_002655.2 817807 819225 D UV-induced DNA repair; converts cyclobutane-type pyrimidine dimers created during exposure to UV ratiation to monomers; light dependent; deoxyribodipyrimidine photolyase 817807..819225 Escherichia coli O157:H7 str. EDL933 957799 NP_286424.1 CDS ybgH NC_002655.2 819375 820856 R transporter complement(819375..820856) Escherichia coli O157:H7 str. EDL933 957800 NP_286425.1 CDS ybgI NC_002655.2 821127 821870 D hydrolase-oxidase 821127..821870 Escherichia coli O157:H7 str. EDL933 957801 NP_286426.1 CDS ybgJ NC_002655.2 821893 822549 D carboxylase 821893..822549 Escherichia coli O157:H7 str. EDL933 957802 NP_286427.1 CDS ybgK NC_002655.2 822543 823475 D carboxylase 822543..823475 Escherichia coli O157:H7 str. EDL933 957804 NP_286428.1 CDS ybgL NC_002655.2 823465 824199 D LamB/YcsF family protein 823465..824199 Escherichia coli O157:H7 str. EDL933 957805 NP_286429.1 CDS nei NC_002655.2 824235 825026 D 5-formyluracil/5-hydroxymethyluracil DNA glycosylase; involved in base excision repair of DNA damaged by oxidation or by mutagenic agents; acts as DNA glycosylase that recognizes and removes damaged bases with a preference for oxidized pyrimidines; has apurinic/apyrimidinic lyase activity; endonuclease VIII 824235..825026 Escherichia coli O157:H7 str. EDL933 957808 NP_286430.1 CDS abrB NC_002655.2 825023 826114 R transporter complement(825023..826114) Escherichia coli O157:H7 str. EDL933 957811 NP_286431.1 CDS ybgO NC_002655.2 826218 827279 R hypothetical protein complement(826218..827279) Escherichia coli O157:H7 str. EDL933 957812 NP_286432.1 CDS ybgP NC_002655.2 827276 828007 R chaperone complement(827276..828007) Escherichia coli O157:H7 str. EDL933 957813 NP_286433.1 CDS Z0870 NC_002655.2 828022 828171 R hypothetical protein complement(828022..828171) Escherichia coli O157:H7 str. EDL933 957816 NP_286434.1 CDS ybgQ NC_002655.2 828310 830472 R outer membrane usher protein complement(828310..830472) Escherichia coli O157:H7 str. EDL933 957819 NP_286435.1 CDS ybgD NC_002655.2 830531 831097 R fimbriae structural protein complement(830531..831097) Escherichia coli O157:H7 str. EDL933 957821 NP_286436.1 CDS gltA NC_002655.2 831484 832767 R type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; type II citrate synthase complement(831484..832767) Escherichia coli O157:H7 str. EDL933 957824 NP_286437.1 CDS sdhC NC_002655.2 833476 833865 D succinate dehydrogenase cytochrome b556 large membrane subunit 833476..833865 Escherichia coli O157:H7 str. EDL933 957825 NP_286438.1 CDS sdhD NC_002655.2 833859 834206 D succinate dehydrogenase cytochrome b556 small membrane subunit 833859..834206 Escherichia coli O157:H7 str. EDL933 957828 NP_286439.1 CDS sdhA NC_002655.2 834206 835972 D part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; succinate dehydrogenase flavoprotein subunit 834206..835972 Escherichia coli O157:H7 str. EDL933 957829 NP_286440.1 CDS sdhB NC_002655.2 835988 836704 D part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; succinate dehydrogenase iron-sulfur subunit 835988..836704 Escherichia coli O157:H7 str. EDL933 957830 NP_286441.1 CDS Z0879 NC_002655.2 836763 837023 D hypothetical protein 836763..837023 Escherichia coli O157:H7 str. EDL933 957831 NP_286442.1 CDS sucA NC_002655.2 837005 839806 D SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide; 2-oxoglutarate dehydrogenase E1 837005..839806 Escherichia coli O157:H7 str. EDL933 957833 NP_286443.1 CDS sucB NC_002655.2 839821 841038 D component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA; dihydrolipoamide succinyltransferase 839821..841038 Escherichia coli O157:H7 str. EDL933 957834 NP_286444.1 CDS sucC NC_002655.2 841132 842298 D catalyzes the interconversion of succinyl-CoA and succinate; succinyl-CoA synthetase subunit beta 841132..842298 Escherichia coli O157:H7 str. EDL933 957835 NP_286445.1 CDS sucD NC_002655.2 842298 843167 D Catalyzes the only substrate-level phosphorylation in the TCA cycle; succinyl-CoA synthetase subunit alpha 842298..843167 Escherichia coli O157:H7 str. EDL933 957836 NP_286446.1 CDS Z0884 NC_002655.2 843450 843563 D No significant matches; hypothetical protein 843450..843563 Escherichia coli O157:H7 str. EDL933 957838 NP_286447.1 CDS Z0885 NC_002655.2 843834 844739 D LysR family transcriptional regulator 843834..844739 Escherichia coli O157:H7 str. EDL933 957839 NP_286448.1 CDS Z0886 NC_002655.2 844773 845375 R catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide; cob(I)yrinic acid a,c-diamide adenosyltransferase complement(844773..845375) Escherichia coli O157:H7 str. EDL933 957842 NP_286449.1 CDS Z0887 NC_002655.2 845385 847037 R fumarate hydratase complement(845385..847037) Escherichia coli O157:H7 str. EDL933 957844 NP_286450.1 CDS Z0888 NC_002655.2 847145 848425 R symport protein complement(847145..848425) Escherichia coli O157:H7 str. EDL933 957845 NP_286451.1 CDS Z0890 NC_002655.2 848586 848903 R No significant matches; hypothetical protein complement(848586..848903) Escherichia coli O157:H7 str. EDL933 957847 NP_286452.1 CDS Z0891 NC_002655.2 848900 850270 R hypothetical protein complement(848900..850270) Escherichia coli O157:H7 str. EDL933 957849 NP_286453.1 CDS Z0892 NC_002655.2 850274 851515 R methylaspartate ammonia-lyase complement(850274..851515) Escherichia coli O157:H7 str. EDL933 957850 NP_286454.1 CDS Z0893 NC_002655.2 851515 852960 R glutamate mutase subumit E complement(851515..852960) Escherichia coli O157:H7 str. EDL933 957851 NP_286455.1 CDS Z0894 NC_002655.2 852979 854367 R hypothetical protein complement(852979..854367) Escherichia coli O157:H7 str. EDL933 957852 NP_286456.1 CDS Z0895 NC_002655.2 854367 854879 R converts methylaspartate to L-glutamate; methylaspartate mutase subunit S complement(854367..854879) Escherichia coli O157:H7 str. EDL933 957856 NP_286457.1 CDS Z0896 NC_002655.2 855003 855170 R No significant matches; hypothetical protein complement(855003..855170) Escherichia coli O157:H7 str. EDL933 957857 NP_286458.1 CDS Z0897 NC_002655.2 855364 855786 R No significant matches; hypothetical protein complement(855364..855786) Escherichia coli O157:H7 str. EDL933 957859 NP_286459.1 CDS Z0898 NC_002655.2 855868 856812 R No significant matches; hypothetical protein complement(855868..856812) Escherichia coli O157:H7 str. EDL933 957860 NP_286461.1 CDS cydA NC_002655.2 857615 859186 D cytochrome d terminal oxidase, polypeptide subunit I 857615..859186 Escherichia coli O157:H7 str. EDL933 957863 NP_286462.1 CDS cydB NC_002655.2 859202 860341 D cytochrome d terminal oxidase polypeptide subunit II 859202..860341 Escherichia coli O157:H7 str. EDL933 957864 NP_286463.1 CDS ybgE NC_002655.2 860469 860762 D hypothetical protein 860469..860762 Escherichia coli O157:H7 str. EDL933 957865 NP_286464.1 CDS ybgC NC_002655.2 860912 861316 D catalyzes the hydrolysis of short chain aliphatic acyl-CoA thioesters; physiological role remains unknown; involved in phospholipid metabolism; part of the Tol/Pal system of proteins that are critical for maintaining the integrity of the cell envelope components; acyl-CoA thioester hydrolase 860912..861316 Escherichia coli O157:H7 str. EDL933 957866 NP_286465.1 CDS tolQ NC_002655.2 861313 862005 D membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins; colicin uptake protein TolQ 861313..862005 Escherichia coli O157:H7 str. EDL933 957868 NP_286466.1 CDS tolR NC_002655.2 862009 862437 D membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins; colicin uptake protein TolR 862009..862437 Escherichia coli O157:H7 str. EDL933 957870 NP_286467.1 CDS tolA NC_002655.2 862502 863686 D inner membrane component of 7 member Tol-Pal envelope-spanning complex; involved in maintaining cell envelope integrity; utilized by colicins and filamentous phages for import; interacts with TolB, Pal, and through TolB to various outer membrane porins; cell envelope integrity inner membrane protein TolA 862502..863686 Escherichia coli O157:H7 str. EDL933 957872 NP_286468.1 CDS tolB NC_002655.2 863819 865111 D forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA; translocation protein TolB 863819..865111 Escherichia coli O157:H7 str. EDL933 957873 NP_286469.1 CDS pal NC_002655.2 865146 865667 D peptidoglycan-associated outer membrane lipoprotein 865146..865667 Escherichia coli O157:H7 str. EDL933 957874 NP_286470.1 CDS ybgF NC_002655.2 865677 866468 D periplasmic protein that interacts with TolA; the tol-pal system is probably involved in maintaining cell envelope integrity; tol-pal system protein YbgF 865677..866468 Escherichia coli O157:H7 str. EDL933 957876 NP_286471.1 CDS nadA NC_002655.2 867603 868646 D 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate; quinolinate synthetase 867603..868646 Escherichia coli O157:H7 str. EDL933 957889 NP_286472.1 CDS pnuC NC_002655.2 868684 869403 D required for NMN transport 868684..869403 Escherichia coli O157:H7 str. EDL933 957890 NP_286473.1 CDS ybgR NC_002655.2 869400 870335 R involved in zinc efflux across the cytoplasmic membrane; zinc transporter ZitB complement(869400..870335) Escherichia coli O157:H7 str. EDL933 957891 NP_286474.1 CDS Z0923 NC_002655.2 870449 870829 R homeobox protein complement(870449..870829) Escherichia coli O157:H7 str. EDL933 957892 NP_286475.1 CDS aroG NC_002655.2 871145 872197 D catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 871145..872197 Escherichia coli O157:H7 str. EDL933 957894 NP_286476.1 CDS gpmA NC_002655.2 872363 873115 R 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase complement(872363..873115) Escherichia coli O157:H7 str. EDL933 957895 NP_286477.1 CDS galM NC_002655.2 873317 874357 R catalyzes the conversion of alpha-aldose to the beta-anomer; active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose; links the metabolism of lactose and galactose; aldose 1-epimerase complement(873317..874357) Escherichia coli O157:H7 str. EDL933 957897 NP_286478.1 CDS galK NC_002655.2 874351 875499 R catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism; galactokinase complement(874351..875499) Escherichia coli O157:H7 str. EDL933 957898 NP_286479.1 CDS galT NC_002655.2 875503 876549 R catalyzes the interconversion of UDP-galactose and galactose-1-P with UDP-galactose and glucose-1-P; galactose-1-phosphate uridylyltransferase complement(875503..876549) Escherichia coli O157:H7 str. EDL933 957899 NP_286480.1 CDS galE NC_002655.2 876559 877575 R UDP-galactose-4-epimerase complement(876559..877575) Escherichia coli O157:H7 str. EDL933 957904 NP_286481.2 CDS modF NC_002655.2 877837 879309 R contains 2 ATP-binding cassettes; involved in the transport of molybdenum; molybdenum transport ATP-binding protein ModF complement(877837..879309) Escherichia coli O157:H7 str. EDL933 957906 NP_286482.1 CDS modE NC_002655.2 879377 880165 R represses the modABCD operon and activates the moaABCD and napFDAGHBC operons; DNA-binding transcriptional regulator ModE complement(879377..880165) Escherichia coli O157:H7 str. EDL933 957908 NP_286483.1 CDS Z0932 NC_002655.2 880294 880443 D hypothetical protein 880294..880443 Escherichia coli O157:H7 str. EDL933 957909 NP_286484.1 CDS modA NC_002655.2 880610 881383 D with ModCB is involved in the high-affinity transport of molybdate; molybdate transporter periplasmic protein 880610..881383 Escherichia coli O157:H7 str. EDL933 957910 NP_286485.1 CDS modB NC_002655.2 881383 882072 D part of ModCBA molybdate transporter; member of ABC superfamily; inner membrane component; regulated by repressor protein ModE; molybdate ABC transporter permease 881383..882072 Escherichia coli O157:H7 str. EDL933 957911 NP_286486.1 CDS modC NC_002655.2 882075 883133 D Part of the ABC transporter complex modABC involved in molybdenum import; molybdate transporter ATP-binding protein 882075..883133 Escherichia coli O157:H7 str. EDL933 957912 NP_286487.1 CDS ybhA NC_002655.2 883134 883952 R YbhA; catalyzes the dephosphorylation of pyridoxal phosphate, fructose 1,6-bisphosphate, erythrose 4-phosphate and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; phosphotransferase activity observed when using monophosphates as phosphate donor; member of the haloacid dehalogenase-like hydrolases superfamily; phosphotransferase complement(883134..883952) Escherichia coli O157:H7 str. EDL933 957914 NP_286488.1 CDS ybhE NC_002655.2 884107 885102 D catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate; 6-phosphogluconolactonase 884107..885102 Escherichia coli O157:H7 str. EDL933 957915 NP_286489.1 CDS ybhD NC_002655.2 885143 886159 R LysR family transcriptional regulator complement(885143..886159) Escherichia coli O157:H7 str. EDL933 957916 NP_286490.1 CDS ybhH NC_002655.2 886280 887332 D hypothetical protein 886280..887332 Escherichia coli O157:H7 str. EDL933 957919 NP_286491.1 CDS ybhI NC_002655.2 887409 888842 D membrane pump protein 887409..888842 Escherichia coli O157:H7 str. EDL933 957920 NP_286492.2 CDS ybhJ NC_002655.2 889025 891286 D hypothetical protein 889025..891286 Escherichia coli O157:H7 str. EDL933 957921 NP_286493.1 CDS ybhC NC_002655.2 891427 892710 R outer membrane lipoprotein that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; YbhC localizes to the cellular poles; member of pectinesterase; pectinesterase complement(891427..892710) Escherichia coli O157:H7 str. EDL933 957922 NP_286494.1 CDS Z0946 NC_002655.2 892845 893708 R integrase encoded by prophage CP-933K; partial complement(892845..893708) Escherichia coli O157:H7 str. EDL933 957923 NP_286495.1 CDS Z0947 NC_002655.2 894148 894315 R hypothetical protein complement(894148..894315) Escherichia coli O157:H7 str. EDL933 957926 NP_286496.1 CDS Z0948 NC_002655.2 894558 895160 D No significant matches; hypothetical protein 894558..895160 Escherichia coli O157:H7 str. EDL933 957927 NP_286497.1 CDS Z0949 NC_002655.2 895691 895906 R hypothetical protein complement(895691..895906) Escherichia coli O157:H7 str. EDL933 957929 NP_286498.1 CDS Z0950 NC_002655.2 895983 896174 R hypothetical protein complement(895983..896174) Escherichia coli O157:H7 str. EDL933 957931 NP_286499.1 CDS Z0951 NC_002655.2 896326 897006 R exonuclease complement(896326..897006) Escherichia coli O157:H7 str. EDL933 957932 NP_286500.1 CDS Z0952 NC_002655.2 897003 897650 R Bet recombination protein of prophage CP-933K complement(897003..897650) Escherichia coli O157:H7 str. EDL933 957933 NP_286501.1 CDS Z0953 NC_002655.2 898043 898666 D hypothetical protein 898043..898666 Escherichia coli O157:H7 str. EDL933 957934 NP_286502.1 CDS Z0954 NC_002655.2 898894 899325 D hypothetical protein 898894..899325 Escherichia coli O157:H7 str. EDL933 957935 NP_286503.1 CDS Z0955 NC_002655.2 899537 900496 R hypothetical protein complement(899537..900496) Escherichia coli O157:H7 str. EDL933 957936 NP_286504.1 CDS Z0956 NC_002655.2 900887 901660 D antiterminator Q protein of prophage CP-933K 900887..901660 Escherichia coli O157:H7 str. EDL933 957937 NP_286505.1 CDS Z0957 NC_002655.2 901830 902588 D hypothetical protein 901830..902588 Escherichia coli O157:H7 str. EDL933 957938 NP_286506.1 CDS Z0958 NC_002655.2 902731 902832 D No significant matches; hypothetical protein 902731..902832 Escherichia coli O157:H7 str. EDL933 957940 NP_286508.1 CDS Z0960 NC_002655.2 903669 904166 D lysozyme protein R of prophage CP-933K 903669..904166 Escherichia coli O157:H7 str. EDL933 957943 NP_286509.1 CDS Z0961 NC_002655.2 904163 904630 D endopeptidase Rz of prophage CP-933K 904163..904630 Escherichia coli O157:H7 str. EDL933 957945 NP_286510.1 CDS Z0962 NC_002655.2 905200 905295 R No significant matches; hypothetical protein complement(905200..905295) Escherichia coli O157:H7 str. EDL933 957947 NP_286511.1 CDS Z0963 NC_002655.2 905445 905936 D No significant matches; hypothetical protein 905445..905936 Escherichia coli O157:H7 str. EDL933 957948 NP_286512.1 CDS Z0964 NC_002655.2 905936 908038 D DNA packaging protein of prophage CP-933K 905936..908038 Escherichia coli O157:H7 str. EDL933 957949 NP_286513.1 CDS Z0965 NC_002655.2 908175 909299 D hypothetical protein 908175..909299 Escherichia coli O157:H7 str. EDL933 957950 NP_286514.1 CDS Z0966 NC_002655.2 909394 909756 D No significant matches; hypothetical protein 909394..909756 Escherichia coli O157:H7 str. EDL933 957952 NP_286515.1 CDS Z0967 NC_002655.2 909701 911728 D protease encoded in prophage CP-933K 909701..911728 Escherichia coli O157:H7 str. EDL933 957953 NP_286516.1 CDS Z0968 NC_002655.2 911815 912138 D No significant matches; hypothetical protein 911815..912138 Escherichia coli O157:H7 str. EDL933 957955 NP_286517.1 CDS Z0969 NC_002655.2 912131 912406 D No significant matches; hypothetical protein 912131..912406 Escherichia coli O157:H7 str. EDL933 957956 NP_286518.1 CDS Z0970 NC_002655.2 912418 912996 D tail component of prophage CP-933K 912418..912996 Escherichia coli O157:H7 str. EDL933 957958 NP_286519.1 CDS Z0971 NC_002655.2 912993 913394 D tail component of prophage CP-933K 912993..913394 Escherichia coli O157:H7 str. EDL933 957959 NP_286520.1 CDS Z0972 NC_002655.2 913399 914148 D tail component of prophage CP-933K 913399..914148 Escherichia coli O157:H7 str. EDL933 957961 NP_286521.1 CDS Z0973 NC_002655.2 914197 914595 D tail component of prophage CP-933K 914197..914595 Escherichia coli O157:H7 str. EDL933 957962 NP_286522.1 CDS Z0974 NC_002655.2 914616 914933 D tail component of prophage CP-933K 914616..914933 Escherichia coli O157:H7 str. EDL933 957963 NP_286523.1 CDS Z0975 NC_002655.2 914905 917970 D tail component of prophage CP-933K 914905..917970 Escherichia coli O157:H7 str. EDL933 957964 NP_286524.1 CDS Z0976 NC_002655.2 917970 918299 D tail component of prophage CP-933K 917970..918299 Escherichia coli O157:H7 str. EDL933 957966 NP_286525.1 CDS Z0977 NC_002655.2 918309 919007 D tail component of prophage CP-933K 918309..919007 Escherichia coli O157:H7 str. EDL933 957969 NP_286526.1 CDS Z0978 NC_002655.2 919082 919756 D tail component of prophage CP-933K 919082..919756 Escherichia coli O157:H7 str. EDL933 957970 NP_286527.1 CDS Z0979 NC_002655.2 919654 920301 D tail component of prophage CP-933K 919654..920301 Escherichia coli O157:H7 str. EDL933 957973 NP_286528.1 CDS Z0980 NC_002655.2 920362 923778 D tail component of prophage CP-933K 920362..923778 Escherichia coli O157:H7 str. EDL933 957974 NP_286529.1 CDS lomK NC_002655.2 923849 924448 D prophage protein 923849..924448 Escherichia coli O157:H7 str. EDL933 957976 NP_286530.1 CDS Z0982 NC_002655.2 924502 925824 D tail component of prophage CP-933K 924502..925824 Escherichia coli O157:H7 str. EDL933 957977 NP_286531.1 CDS Z0984 NC_002655.2 925787 926095 D hypothetical protein 925787..926095 Escherichia coli O157:H7 str. EDL933 957980 NP_286532.1 CDS Z0985 NC_002655.2 926272 927252 D hypothetical protein 926272..927252 Escherichia coli O157:H7 str. EDL933 957982 NP_286533.1 CDS Z0986 NC_002655.2 927313 928305 D No significant matches; hypothetical protein 927313..928305 Escherichia coli O157:H7 str. EDL933 957984 NP_286534.1 CDS Z0989 NC_002655.2 929133 930014 D No significant matches; hypothetical protein 929133..930014 Escherichia coli O157:H7 str. EDL933 957985 NP_286535.1 CDS Z0990 NC_002655.2 930245 930943 D No significant matches; hypothetical protein 930245..930943 Escherichia coli O157:H7 str. EDL933 957986 NP_286536.1 CDS ybhB NC_002655.2 931451 931927 R YbhB; similar to rat and human kinase inhibitory proteins; kinase inhibitor protein complement(931451..931927) Escherichia coli O157:H7 str. EDL933 957989 NP_286537.1 CDS bioA NC_002655.2 931986 933275 R catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate; adenosylmethionine-8-amino-7-oxononanoate aminotransferase complement(931986..933275) Escherichia coli O157:H7 str. EDL933 957991 NP_286538.1 CDS bioB NC_002655.2 933362 934402 D biotin synthase 933362..934402 Escherichia coli O157:H7 str. EDL933 957992 NP_286539.1 CDS bioF NC_002655.2 934399 935553 D catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine; 8-amino-7-oxononanoate synthase 934399..935553 Escherichia coli O157:H7 str. EDL933 957994 NP_286540.1 CDS bioC NC_002655.2 935540 936295 D methyltransferase; acyl carrier protein involved in an unidentified step in the synthesis of pimeloyl-CoA, a biotin precursor; member of the bio operon (bioABFCD); in Escherichia coli, bioC-null mutants require biotin for growth; biotin biosynthesis protein BioC 935540..936295 Escherichia coli O157:H7 str. EDL933 957995 NP_286541.1 CDS bioD NC_002655.2 936288 936965 D DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase 936288..936965 Escherichia coli O157:H7 str. EDL933 957997 NP_286542.1 CDS uvrB NC_002655.2 937545 939566 D The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 937545..939566 Escherichia coli O157:H7 str. EDL933 957998 NP_286543.1 CDS ybhK NC_002655.2 939757 940665 R structural protein complement(939757..940665) Escherichia coli O157:H7 str. EDL933 957999 NP_286544.1 CDS moaA NC_002655.2 941062 942051 D together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z; molybdenum cofactor biosynthesis protein A 941062..942051 Escherichia coli O157:H7 str. EDL933 958000 NP_286545.1 CDS moaB NC_002655.2 942073 942585 D molybdopterin biosynthesis, protein B 942073..942585 Escherichia coli O157:H7 str. EDL933 958001 NP_286546.1 CDS moaC NC_002655.2 942588 943073 D MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MoaC 942588..943073 Escherichia coli O157:H7 str. EDL933 958003 NP_286547.1 CDS moaD NC_002655.2 943066 943311 D catalyzes the conversion of molybdopterin precursor Z into molybdopterin; molybdopterin synthase small subunit 943066..943311 Escherichia coli O157:H7 str. EDL933 958004 NP_286548.1 CDS moaE NC_002655.2 943313 943765 D catalyzes the conversion of molybdopterin precursor Z into molybdopterin; molybdopterin guanine dinucleotide biosynthesis protein MoaE 943313..943765 Escherichia coli O157:H7 str. EDL933 958005 NP_286549.1 CDS ybhL NC_002655.2 943901 944605 D hypothetical protein 943901..944605 Escherichia coli O157:H7 str. EDL933 958007 NP_286550.1 CDS ybhM NC_002655.2 944813 945526 D hypothetical protein 944813..945526 Escherichia coli O157:H7 str. EDL933 958010 NP_286551.1 CDS ybhN NC_002655.2 945562 946518 R hypothetical protein complement(945562..946518) Escherichia coli O157:H7 str. EDL933 958011 NP_286552.1 CDS ybhO NC_002655.2 946518 947759 R cardiolipin synthase 2 complement(946518..947759) Escherichia coli O157:H7 str. EDL933 958012 NP_286553.1 CDS ybhP NC_002655.2 947756 948517 R hypothetical protein complement(947756..948517) Escherichia coli O157:H7 str. EDL933 958013 NP_286554.1 CDS ybhQ NC_002655.2 948650 949060 D hypothetical protein 948650..949060 Escherichia coli O157:H7 str. EDL933 958014 NP_286555.1 CDS ybhR NC_002655.2 949022 950128 R hypothetical protein complement(949022..950128) Escherichia coli O157:H7 str. EDL933 958016 NP_286556.1 CDS ybhS NC_002655.2 950139 951272 R hypothetical protein complement(950139..951272) Escherichia coli O157:H7 str. EDL933 958017 NP_286557.1 CDS ybhF NC_002655.2 951265 953016 R ABC transporter ATP-binding protein complement(951265..953016) Escherichia coli O157:H7 str. EDL933 958020 NP_286558.1 CDS Z1015 NC_002655.2 952994 953992 R hypothetical protein complement(952994..953992) Escherichia coli O157:H7 str. EDL933 958021 NP_286559.1 CDS ybiH NC_002655.2 953992 954675 R DNA-binding transcriptional regulator complement(953992..954675) Escherichia coli O157:H7 str. EDL933 958023 NP_286560.1 CDS rhlE NC_002655.2 954892 956259 D this helicase is not essential cell growth; ATP-dependent RNA helicase RhlE 954892..956259 Escherichia coli O157:H7 str. EDL933 958024 NP_286561.1 CDS Z1018 NC_002655.2 956323 956421 D No significant matches; hypothetical protein 956323..956421 Escherichia coli O157:H7 str. EDL933 958025 NP_286562.1 CDS Z1019 NC_002655.2 956867 958879 D hypothetical protein 956867..958879 Escherichia coli O157:H7 str. EDL933 958026 NP_286563.1 CDS dinG NC_002655.2 959163 961313 D helicase involved in DNA repair and perhaps also replication; ATP-dependent DNA helicase DinG 959163..961313 Escherichia coli O157:H7 str. EDL933 958028 NP_286564.1 CDS ybiB NC_002655.2 961341 962303 D glycosyl transferase 961341..962303 Escherichia coli O157:H7 str. EDL933 958029 NP_286565.1 CDS ybiC NC_002655.2 962445 963530 D hypothetical protein 962445..963530 Escherichia coli O157:H7 str. EDL933 958033 NP_286566.1 CDS ybiJ NC_002655.2 963760 964020 R hypothetical protein complement(963760..964020) Escherichia coli O157:H7 str. EDL933 958035 NP_286567.1 CDS ybiI NC_002655.2 964285 964551 R hypothetical protein complement(964285..964551) Escherichia coli O157:H7 str. EDL933 958039 NP_286568.1 CDS ybiX NC_002655.2 964627 965313 R hydroxylase complement(964627..965313) Escherichia coli O157:H7 str. EDL933 958040 NP_286569.1 CDS Z1026 NC_002655.2 965355 967637 R Fiu; YbiL; porin involved in the uptake of iron complexed with catecholate siderophores (e.g. dihydroxybenzoylserine, dihydroxybenzoate) and beta lactam agents; Fiu interacts with TonB which provides the energy required for transport across the outer membrane; acts as a receptor for iron-siderophores and microcins E492, M, and H47; outer membrane protein; catecholate siderophore receptor Fiu complement(965355..967637) Escherichia coli O157:H7 str. EDL933 958041 NP_286570.1 CDS ybiM NC_002655.2 967902 968306 R hypothetical protein complement(967902..968306) Escherichia coli O157:H7 str. EDL933 958042 NP_286571.1 CDS ybiN NC_002655.2 968357 969364 D SAM-dependent methyltransferase 968357..969364 Escherichia coli O157:H7 str. EDL933 958047 NP_286572.1 CDS ybiO NC_002655.2 969361 971586 R hypothetical protein complement(969361..971586) Escherichia coli O157:H7 str. EDL933 958048 NP_286573.1 CDS glnQ NC_002655.2 971703 972425 R similar to ABC transporter ATP-binding proteins; glutamine ABC transporter ATP-binding protein complement(971703..972425) Escherichia coli O157:H7 str. EDL933 958052 NP_286574.1 CDS glnP NC_002655.2 972422 973081 R similar to permease component of ABC transporters; mutations impair ability of Escherichia coli to transport and utilize glutamine; glutamine ABC transporter permease complement(972422..973081) Escherichia coli O157:H7 str. EDL933 958053 NP_286575.1 CDS glnH NC_002655.2 973220 973966 R similar to periplasmic-binding component of ABC transporters; glutamine ABC transporter periplasmic protein complement(973220..973966) Escherichia coli O157:H7 str. EDL933 958054 NP_286576.1 CDS dps NC_002655.2 974370 974873 R binds DNA in a non-sequence-specific manner and is abundant during stationary phase; forms a DNA-protein crystal that protects DNA from damage; required for normal starvation response and long-term stationary viability; forms a homododecameric complex and sequesters iron which provides protection against oxidative damage; DNA starvation/stationary phase protection protein Dps complement(974370..974873) Escherichia coli O157:H7 str. EDL933 958055 NP_286577.1 CDS ybiF NC_002655.2 975172 976059 R threonine and homoserine efflux system complement(975172..976059) Escherichia coli O157:H7 str. EDL933 958056 NP_286578.1 CDS ompX NC_002655.2 976412 976927 D OmpX; involved in cell adhesion; forms an eight-stranded antiparallel beta-barrel that protrudes from the cell surface; mutations in the gene increase cell-surface contact in fimbriated strains but decrease contact in nonfimbriated strains; outer membrane protein X 976412..976927 Escherichia coli O157:H7 str. EDL933 958057 NP_286579.1 CDS ybiP NC_002655.2 976976 978559 R hypothetical protein complement(976976..978559) Escherichia coli O157:H7 str. EDL933 958061 NP_286580.1 CDS Z1038 NC_002655.2 978795 978902 D hypothetical protein 978795..978902 Escherichia coli O157:H7 str. EDL933 958074 NP_286581.1 CDS Z1039 NC_002655.2 979145 979612 D Transcriptional regulator that represses the manganese transporter MntH when manganese is present; manganese transport regulator MntR 979145..979612 Escherichia coli O157:H7 str. EDL933 958082 NP_286582.1 CDS ybiR NC_002655.2 979609 980727 D hypothetical protein 979609..980727 Escherichia coli O157:H7 str. EDL933 958083 NP_286583.1 CDS ybiS NC_002655.2 980785 981705 R hypothetical protein complement(980785..981705) Escherichia coli O157:H7 str. EDL933 958084 NP_286584.1 CDS ybiT NC_002655.2 981925 983517 D ABC transporter ATP-binding protein 981925..983517 Escherichia coli O157:H7 str. EDL933 958094 NP_286585.1 CDS ybiU NC_002655.2 983685 984950 R hypothetical protein complement(983685..984950) Escherichia coli O157:H7 str. EDL933 958095 NP_286586.1 CDS Z1044 NC_002655.2 985103 985918 R hypothetical protein complement(985103..985918) Escherichia coli O157:H7 str. EDL933 958099 NP_286587.1 CDS Z1046m NC_002655.2 986064 988495 R pyruvate-formate lyase complement(join(986064..987962,987962..988495)) Escherichia coli O157:H7 str. EDL933 959651 NP_286588.2 CDS ybiY NC_002655.2 988501 989400 R pyruvate formate-lyase 2 activating enzyme complement(988501..989400) Escherichia coli O157:H7 str. EDL933 958103 NP_286589.2 CDS mipB NC_002655.2 989531 990193 D similar to transaldolase from Escherichia coli; many organisms have multiple copies; fructose-6-phosphate aldolase 989531..990193 Escherichia coli O157:H7 str. EDL933 958104 NP_286590.1 CDS moeB NC_002655.2 990372 991121 R ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase; molybdopterin biosynthesis protein MoeB complement(990372..991121) Escherichia coli O157:H7 str. EDL933 958112 NP_286591.1 CDS moeA NC_002655.2 991121 992356 R is involved in the formation of active molybdenum cofactor and the chelation of molybdenum; molybdopterin biosynthesis protein MoeA complement(991121..992356) Escherichia coli O157:H7 str. EDL933 958116 NP_286592.1 CDS Z1051m NC_002655.2 992560 993525 D L-asparaginase 992560..993525 Escherichia coli O157:H7 str. EDL933 959650 NP_286593.1 CDS Z1053 NC_002655.2 993545 995383 D with GsiBCD is involved in glutathione import; GsiA contains 2 ATP-binding domains; glutathione transporter ATP-binding protein 993545..995383 Escherichia coli O157:H7 str. EDL933 958119 NP_286594.1 CDS Z1054 NC_002655.2 995403 996941 D transporter 995403..996941 Escherichia coli O157:H7 str. EDL933 958120 NP_286595.1 CDS Z1055 NC_002655.2 996959 997879 D transport system permease 996959..997879 Escherichia coli O157:H7 str. EDL933 958122 NP_286596.1 CDS Z1056 NC_002655.2 997882 998793 D transport system permease 997882..998793 Escherichia coli O157:H7 str. EDL933 958128 NP_286597.1 CDS Z1057 NC_002655.2 998971 1001319 D hypothetical protein 998971..1001319 Escherichia coli O157:H7 str. EDL933 958133 NP_286598.1 CDS Z1058 NC_002655.2 1001327 1002655 D hypothetical protein 1001327..1002655 Escherichia coli O157:H7 str. EDL933 958134 NP_286599.1 CDS Z1059 NC_002655.2 1002725 1003054 R hypothetical protein complement(1002725..1003054) Escherichia coli O157:H7 str. EDL933 958141 NP_286600.1 CDS Z1060 NC_002655.2 1003044 1003430 R hypothetical protein complement(1003044..1003430) Escherichia coli O157:H7 str. EDL933 958143 NP_286601.1 CDS rimO NC_002655.2 1003656 1004981 R catalyzes the methylthiolation of an aspartic acid residue of the S12 protein of the 30S ribosomal subunit; ribosomal protein S12 methylthiotransferase complement(1003656..1004981) Escherichia coli O157:H7 str. EDL933 958145 NP_286602.1 CDS bssR NC_002655.2 1005194 1005577 D BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing; biofilm formation regulatory protein BssR 1005194..1005577 Escherichia coli O157:H7 str. EDL933 958146 NP_286603.1 CDS yliI NC_002655.2 1005688 1006803 D dehydrogenase 1005688..1006803 Escherichia coli O157:H7 str. EDL933 958149 NP_286604.1 CDS yliJ NC_002655.2 1006800 1007432 R transferase complement(1006800..1007432) Escherichia coli O157:H7 str. EDL933 958156 NP_286605.1 CDS dacC NC_002655.2 1007672 1008874 D penicillin-binding protein 6a; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains; D-alanyl-D-alanine carboxypeptidase 1007672..1008874 Escherichia coli O157:H7 str. EDL933 958157 NP_286606.1 CDS deoR NC_002655.2 1008921 1009679 R DeoR family transcriptional regulator complement(1008921..1009679) Escherichia coli O157:H7 str. EDL933 958158 NP_286607.1 CDS ybjG NC_002655.2 1009737 1010333 R undecaprenyl pyrophosphate phosphatase complement(1009737..1010333) Escherichia coli O157:H7 str. EDL933 958159 NP_286608.1 CDS cmr NC_002655.2 1010618 1011850 D proton motive force efflux pump 1010618..1011850 Escherichia coli O157:H7 str. EDL933 958160 NP_286609.1 CDS ybjH NC_002655.2 1011891 1012175 R hypothetical protein complement(1011891..1012175) Escherichia coli O157:H7 str. EDL933 958168 NP_286610.1 CDS Z1071 NC_002655.2 1012261 1013049 R hypothetical protein complement(1012261..1013049) Escherichia coli O157:H7 str. EDL933 958173 NP_286611.1 CDS Z1072 NC_002655.2 1013076 1014284 R DEOR-type transcriptional regulator complement(1013076..1014284) Escherichia coli O157:H7 str. EDL933 958182 NP_286612.1 CDS Z1073 NC_002655.2 1014368 1014904 D DEOR-type transcriptional regulator 1014368..1014904 Escherichia coli O157:H7 str. EDL933 958183 NP_286613.1 CDS Z1074 NC_002655.2 1015079 1016764 R hypothetical protein complement(1015079..1016764) Escherichia coli O157:H7 str. EDL933 958193 NP_286614.1 CDS ybjM NC_002655.2 1017035 1017412 D hypothetical protein 1017035..1017412 Escherichia coli O157:H7 str. EDL933 958194 NP_286615.1 CDS grxA NC_002655.2 1017442 1017699 R functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase; also involved in reducing some disulfides in a coupled system with glutathione reductase; glutaredoxin complement(1017442..1017699) Escherichia coli O157:H7 str. EDL933 958195 NP_286616.1 CDS ybjC NC_002655.2 1017859 1018146 D YbjC; located in the same operon as the nfsA gene; member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress; induced by paraquat; regulated by SoxS; unknown function; hypothetical protein 1017859..1018146 Escherichia coli O157:H7 str. EDL933 958199 NP_286617.1 CDS mdaA NC_002655.2 1018130 1018852 D NADPH-dependent; oxygen-insensitive; catalyzes the reduction of nitroaromatic compounds; nitroreductase A 1018130..1018852 Escherichia coli O157:H7 str. EDL933 958200 NP_286618.1 CDS rimK NC_002655.2 1018913 1019815 D responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6; ribosomal protein S6 modification protein 1018913..1019815 Escherichia coli O157:H7 str. EDL933 958206 NP_286619.1 CDS ybjN NC_002655.2 1019903 1020379 D sensory transduction regulator 1019903..1020379 Escherichia coli O157:H7 str. EDL933 958210 NP_286620.1 CDS potF NC_002655.2 1020730 1021842 D putrescine ABC transporter periplasmic-binding protein 1020730..1021842 Escherichia coli O157:H7 str. EDL933 958211 NP_286621.1 CDS potG NC_002655.2 1021937 1023070 D part of the PotFGHI ATP-dependent putrescine transporter; putrescine ABC transporter ATP-binding protein 1021937..1023070 Escherichia coli O157:H7 str. EDL933 958215 NP_286622.1 CDS potH NC_002655.2 1023080 1024033 D putrescine ABC transporter membrane protein 1023080..1024033 Escherichia coli O157:H7 str. EDL933 958218 NP_286623.1 CDS potI NC_002655.2 1024030 1024875 D putrescine ABC transporter membrane protein 1024030..1024875 Escherichia coli O157:H7 str. EDL933 958223 NP_286624.1 CDS ybjO NC_002655.2 1024935 1025423 D hypothetical protein 1024935..1025423 Escherichia coli O157:H7 str. EDL933 958224 NP_286625.1 CDS rumB NC_002655.2 1025464 1026591 D RNA uridine methyltransferase B; catalyzes the formation of 5-methyl-uridine at position 747 in 23S rRNA; 23S rRNA methyluridine methyltransferase 1025464..1026591 Escherichia coli O157:H7 str. EDL933 958225 NP_286626.1 CDS ulaA NC_002655.2 1026871 1028214 D membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC 1026871..1028214 Escherichia coli O157:H7 str. EDL933 958237 NP_286627.1 CDS Z1088 NC_002655.2 1028236 1028556 D hypothetical protein 1028236..1028556 Escherichia coli O157:H7 str. EDL933 958238 NP_286628.1 CDS Z1089 NC_002655.2 1028568 1030049 D sulfatase 1028568..1030049 Escherichia coli O157:H7 str. EDL933 958249 NP_286629.1 CDS artJ NC_002655.2 1030100 1030882 R arginine ABC transporter substrate-binding protein complement(1030100..1030882) Escherichia coli O157:H7 str. EDL933 958254 NP_286630.1 CDS artM NC_002655.2 1031122 1031790 R with ArtPQJI acts to transport arginine across the inner membrane; arginine transporter permease subunit ArtM complement(1031122..1031790) Escherichia coli O157:H7 str. EDL933 958255 NP_286631.1 CDS artQ NC_002655.2 1031790 1032506 R with ArtPMJI transports arginine across the inner membrane; arginine transporter permease subunit ArtQ complement(1031790..1032506) Escherichia coli O157:H7 str. EDL933 958269 NP_286632.1 CDS artI NC_002655.2 1032513 1033244 R arginine ABC transporter substrate-binding protein complement(1032513..1033244) Escherichia coli O157:H7 str. EDL933 958271 NP_286633.1 CDS artP NC_002655.2 1033262 1033990 R With ArtMQJI transports arginine across the inner membrane; arginine transporter ATP-binding subunit complement(1033262..1033990) Escherichia coli O157:H7 str. EDL933 958275 NP_286634.1 CDS ybjP NC_002655.2 1034208 1034729 R induced during stationary phase and by acivicin (a glutamine analog); regulated by Lrp and RpoS; lipoprotein complement(1034208..1034729) Escherichia coli O157:H7 str. EDL933 958281 NP_286635.1 CDS Z1096 NC_002655.2 1034737 1034919 R No significant matches; hypothetical protein complement(1034737..1034919) Escherichia coli O157:H7 str. EDL933 958283 NP_286636.1 CDS Z1097 NC_002655.2 1035348 1036589 D No significant matches; hypothetical protein 1035348..1036589 Escherichia coli O157:H7 str. EDL933 958293 NP_286637.1 CDS Z1098 NC_002655.2 1036699 1037154 D No significant matches; hypothetical protein 1036699..1037154 Escherichia coli O157:H7 str. EDL933 958306 NP_286638.1 CDS Z1099 NC_002655.2 1037365 1037688 D hypothetical protein 1037365..1037688 Escherichia coli O157:H7 str. EDL933 958317 NP_286639.1 CDS Z1100 NC_002655.2 1037685 1038515 D regulator 1037685..1038515 Escherichia coli O157:H7 str. EDL933 958329 NP_286640.1 CDS Z1102 NC_002655.2 1038512 1039561 R nucleotide di-P-sugar epimerase or dehydratase complement(1038512..1039561) Escherichia coli O157:H7 str. EDL933 958348 NP_286641.1 CDS ybjT NC_002655.2 1039624 1041054 R dTDP-glucose enzyme complement(1039624..1041054) Escherichia coli O157:H7 str. EDL933 958350 NP_286642.1 CDS ybjU NC_002655.2 1041065 1042066 R low- specificity; catalyzes the formation of acetaldehyde and glycine from L-threonine; acts on L-threonine, L-allo-threonine, L-threo-phenylserine, and L-erythro-phenylserine; L-threonine aldolase complement(1041065..1042066) Escherichia coli O157:H7 str. EDL933 958351 NP_286643.1 CDS poxB NC_002655.2 1042103 1043821 R catalyzes the formation of acetate from pyruvate; pyruvate dehydrogenase complement(1042103..1043821) Escherichia coli O157:H7 str. EDL933 958381 NP_286644.1 CDS Z1106 NC_002655.2 1043954 1044922 R HCP oxidoreductase complement(1043954..1044922) Escherichia coli O157:H7 str. EDL933 958384 NP_286645.2 CDS ybjW NC_002655.2 1044934 1046586 R catalyzes the reduction of hydroxylamine to ammonia and water; hydroxylamine reductase complement(1044934..1046586) Escherichia coli O157:H7 str. EDL933 958391 NP_286646.1 CDS ybjE NC_002655.2 1046730 1047629 R surface protein complement(1046730..1047629) Escherichia coli O157:H7 str. EDL933 958392 NP_286647.1 CDS aqpZ NC_002655.2 1048087 1048782 R porin involved in osmoregulation allowing water to move into and out of the cell in response to osmotic pressure; aquaporin Z complement(1048087..1048782) Escherichia coli O157:H7 str. EDL933 958402 NP_286648.1 CDS ybjD NC_002655.2 1049208 1050866 D hypothetical protein 1049208..1050866 Escherichia coli O157:H7 str. EDL933 958404 NP_286649.1 CDS ybjX NC_002655.2 1050863 1051855 R hypothetical protein complement(1050863..1051855) Escherichia coli O157:H7 str. EDL933 958410 NP_286650.2 CDS Z1115 NC_002655.2 1051970 1053085 D confers macrolide resistance via active drug efflux; macrolide transporter subunit MacA 1051970..1053085 Escherichia coli O157:H7 str. EDL933 958411 NP_286651.1 CDS ybjZ NC_002655.2 1053082 1055028 D with MacA is involved in the export of macrolide; macrolide transporter ATP-binding /permease 1053082..1055028 Escherichia coli O157:H7 str. EDL933 958415 NP_286652.1 CDS cspD NC_002655.2 1055101 1055325 R inhibits DNA replication at both initiation and elongation steps; stationary phase and starvation inducible; stationary phase/starvation inducible regulatory protein CspD complement(1055101..1055325) Escherichia coli O157:H7 str. EDL933 958429 NP_286653.1 CDS clpS NC_002655.2 1055648 1055968 D involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA; ATP-dependent Clp protease adaptor protein ClpS 1055648..1055968 Escherichia coli O157:H7 str. EDL933 958433 NP_286654.1 CDS clpA NC_002655.2 1055999 1058275 D ATPase and specificity subunit of the ClpA-ClpP ATP dependent serine protease; directs protease to specific substrates; ATP-dependent Clp protease ATP-binding subunit 1055999..1058275 Escherichia coli O157:H7 str. EDL933 958434 NP_286655.1 CDS Z1120 NC_002655.2 1058795 1059997 D P4 family integrase 1058795..1059997 Escherichia coli O157:H7 str. EDL933 958437 NP_286656.1 CDS Z1121 NC_002655.2 1060184 1062001 R No significant matches; hypothetical protein complement(1060184..1062001) Escherichia coli O157:H7 str. EDL933 958445 NP_286657.1 CDS Z1122 NC_002655.2 1062369 1062470 D hypothetical protein 1062369..1062470 Escherichia coli O157:H7 str. EDL933 958450 NP_286658.1 CDS Z1123 NC_002655.2 1062497 1062934 D hypothetical protein 1062497..1062934 Escherichia coli O157:H7 str. EDL933 958463 NP_286659.1 CDS Z1124 NC_002655.2 1063113 1063409 D prophage regulatory protein 1063113..1063409 Escherichia coli O157:H7 str. EDL933 958484 NP_286660.1 CDS Z1125 NC_002655.2 1063636 1063833 D hypothetical protein 1063636..1063833 Escherichia coli O157:H7 str. EDL933 958509 NP_286661.1 CDS Z1126 NC_002655.2 1064034 1065437 D hypothetical protein 1064034..1065437 Escherichia coli O157:H7 str. EDL933 958522 NP_286663.1 CDS Z1128 NC_002655.2 1066258 1066821 D No significant matches; hypothetical protein 1066258..1066821 Escherichia coli O157:H7 str. EDL933 958524 NP_286664.1 CDS Z1129 NC_002655.2 1066952 1069336 D helicase 1066952..1069336 Escherichia coli O157:H7 str. EDL933 958525 NP_286665.1 CDS Z1130 NC_002655.2 1069498 1069767 R No significant matches; hypothetical protein complement(1069498..1069767) Escherichia coli O157:H7 str. EDL933 958531 NP_286666.1 CDS Z1131 NC_002655.2 1070093 1071631 R hypothetical protein complement(1070093..1071631) Escherichia coli O157:H7 str. EDL933 958535 NP_286667.1 CDS Z1132 NC_002655.2 1071681 1072028 R hypothetical protein complement(1071681..1072028) Escherichia coli O157:H7 str. EDL933 958538 NP_286668.1 CDS Z1133 NC_002655.2 1072481 1072792 R transposase complement(1072481..1072792) Escherichia coli O157:H7 str. EDL933 958542 NP_286669.1 CDS Z1134 NC_002655.2 1072932 1073750 D hypothetical protein 1072932..1073750 Escherichia coli O157:H7 str. EDL933 958543 NP_286670.1 CDS Z1135 NC_002655.2 1073863 1074402 D complement resistance protein 1073863..1074402 Escherichia coli O157:H7 str. EDL933 958544 NP_286671.1 CDS Z1136 NC_002655.2 1074450 1074743 R No significant matches; hypothetical protein complement(1074450..1074743) Escherichia coli O157:H7 str. EDL933 958547 NP_286672.1 CDS Z1137 NC_002655.2 1074725 1075015 R No significant matches; hypothetical protein complement(1074725..1075015) Escherichia coli O157:H7 str. EDL933 958553 NP_286673.1 CDS Z1138 NC_002655.2 1075148 1075222 D No significant matches; hypothetical protein 1075148..1075222 Escherichia coli O157:H7 str. EDL933 958557 NP_286674.1 CDS Z1139 NC_002655.2 1075701 1076060 D diacylglycerol kinase 1075701..1076060 Escherichia coli O157:H7 str. EDL933 958566 NP_286675.1 CDS Z1140 NC_002655.2 1076153 1077772 R hypothetical protein complement(1076153..1077772) Escherichia coli O157:H7 str. EDL933 958567 NP_286676.1 CDS Z1141 NC_002655.2 1077997 1078278 R No significant matches; hypothetical protein complement(1077997..1078278) Escherichia coli O157:H7 str. EDL933 958570 NP_286677.1 CDS ureD NC_002655.2 1078653 1079351 D urease accessory protein D 1078653..1079351 Escherichia coli O157:H7 str. EDL933 958575 NP_286678.1 CDS ureA NC_002655.2 1079442 1079744 D UreA, with UreB and UreC catalyzes the hydrolysis of urea into ammonia and carbon dioxide; nickel metalloenzyme; accessory proteins UreD, UreE, UreF, and UreG are necessary for assembly of the metallocenter; urease subunit gamma 1079442..1079744 Escherichia coli O157:H7 str. EDL933 958577 NP_286679.1 CDS ureB NC_002655.2 1079753 1080073 D ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori and Yersinia enterocolitica the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 UreC (alpha) and 3 UreAB (gamma/beta); in Brucella suis the urease encoded by this operon (one of two urease-encoding operons found in its genome) is involved with urease activity, optimum growth, resistance to low-pH killing in-vitro and persistence in-vivo, while the other operon does not seem to be active; urease subunit beta 1079753..1080073 Escherichia coli O157:H7 str. EDL933 958579 NP_286680.1 CDS ureC NC_002655.2 1080063 1081769 D ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits; urease subunit alpha 1080063..1081769 Escherichia coli O157:H7 str. EDL933 958581 NP_286681.1 CDS ureE NC_002655.2 1081779 1082243 D involved in the assembly of the urease metallocenter; possible nickel donor; urease accessory protein UreE 1081779..1082243 Escherichia coli O157:H7 str. EDL933 958583 NP_286682.1 CDS ureF NC_002655.2 1082244 1082918 D urease accessory protein F 1082244..1082918 Escherichia coli O157:H7 str. EDL933 958588 NP_286683.1 CDS ureG NC_002655.2 1082930 1083547 D urease accessory protein G 1082930..1083547 Escherichia coli O157:H7 str. EDL933 958601 NP_286684.1 CDS Z1149 NC_002655.2 1083595 1083726 R hypothetical protein complement(1083595..1083726) Escherichia coli O157:H7 str. EDL933 958644 NP_286685.1 CDS Z1150 NC_002655.2 1083803 1084144 R hypothetical protein complement(1083803..1084144) Escherichia coli O157:H7 str. EDL933 958653 NP_286686.1 CDS Z1151 NC_002655.2 1084206 1084334 R hypothetical protein complement(1084206..1084334) Escherichia coli O157:H7 str. EDL933 958664 NP_286687.1 CDS rpmE2 NC_002655.2 1084759 1085022 D RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 1084759..1085022 Escherichia coli O157:H7 str. EDL933 958672 NP_286688.1 CDS Z1153 NC_002655.2 1085324 1085464 D No significant matches; hypothetical protein 1085324..1085464 Escherichia coli O157:H7 str. EDL933 958685 NP_286689.1 CDS Z1154 NC_002655.2 1085879 1086031 R No significant matches; hypothetical protein complement(1085879..1086031) Escherichia coli O157:H7 str. EDL933 958700 NP_286690.1 CDS Z1155 NC_002655.2 1086337 1087074 R No significant matches; hypothetical protein complement(1086337..1087074) Escherichia coli O157:H7 str. EDL933 958705 NP_286691.1 CDS Z1156 NC_002655.2 1087457 1087597 R No significant matches; hypothetical protein complement(1087457..1087597) Escherichia coli O157:H7 str. EDL933 958708 NP_286692.1 CDS Z1157 NC_002655.2 1088028 1088201 R No significant matches; hypothetical protein complement(1088028..1088201) Escherichia coli O157:H7 str. EDL933 958710 NP_286693.1 CDS Z1158 NC_002655.2 1088541 1089026 R hypothetical protein complement(1088541..1089026) Escherichia coli O157:H7 str. EDL933 958711 NP_286694.1 CDS Z1159 NC_002655.2 1089346 1089771 D hypothetical protein 1089346..1089771 Escherichia coli O157:H7 str. EDL933 958712 NP_286695.1 CDS Z1160 NC_002655.2 1089768 1090118 D hypothetical protein 1089768..1090118 Escherichia coli O157:H7 str. EDL933 958714 NP_286696.1 CDS Z1161 NC_002655.2 1090149 1091762 D hypothetical protein 1090149..1091762 Escherichia coli O157:H7 str. EDL933 958715 NP_286697.1 CDS Z1162 NC_002655.2 1091766 1092623 R hypothetical protein complement(1091766..1092623) Escherichia coli O157:H7 str. EDL933 958717 NP_286698.1 CDS Z1163 NC_002655.2 1092705 1093067 R hypothetical protein complement(1092705..1093067) Escherichia coli O157:H7 str. EDL933 958719 NP_286699.1 CDS terW NC_002655.2 1093623 1094090 R hypothetical protein complement(1093623..1094090) Escherichia coli O157:H7 str. EDL933 958721 NP_286700.1 CDS Z1165 NC_002655.2 1094108 1095316 R No significant matches; hypothetical protein complement(1094108..1095316) Escherichia coli O157:H7 str. EDL933 958722 NP_286701.1 CDS Z1166 NC_002655.2 1095327 1096283 R hypothetical protein complement(1095327..1096283) Escherichia coli O157:H7 str. EDL933 958726 NP_286702.1 CDS Z1167 NC_002655.2 1096283 1097398 R hypothetical protein complement(1096283..1097398) Escherichia coli O157:H7 str. EDL933 958727 NP_286703.1 CDS Z1168 NC_002655.2 1097364 1098359 R hypothetical protein complement(1097364..1098359) Escherichia coli O157:H7 str. EDL933 958733 NP_286704.1 CDS Z1169 NC_002655.2 1098130 1099272 R hypothetical protein complement(1098130..1099272) Escherichia coli O157:H7 str. EDL933 958736 NP_286705.1 CDS Z1170 NC_002655.2 1099282 1100340 R hypothetical protein complement(1099282..1100340) Escherichia coli O157:H7 str. EDL933 958739 NP_286706.1 CDS terZ NC_002655.2 1100663 1101244 D phage inhibition, colicin resistance and tellurite resistance protein 1100663..1101244 Escherichia coli O157:H7 str. EDL933 958741 NP_286707.1 CDS terA NC_002655.2 1101244 1102401 D phage inhibition, colicin resistance and tellurite resistance protein 1101244..1102401 Escherichia coli O157:H7 str. EDL933 958742 NP_286708.1 CDS terB NC_002655.2 1102424 1102879 D phage inhibition, colicin resistance and tellurite resistance protein 1102424..1102879 Escherichia coli O157:H7 str. EDL933 958743 NP_286709.1 CDS terC NC_002655.2 1102902 1103942 D phage inhibition, colicin resistance and tellurite resistance protein 1102902..1103942 Escherichia coli O157:H7 str. EDL933 958744 NP_286710.1 CDS terD NC_002655.2 1103991 1104569 D phage inhibition, colicin resistance and tellurite resistance protein 1103991..1104569 Escherichia coli O157:H7 str. EDL933 958745 NP_286711.1 CDS terE NC_002655.2 1104638 1105213 D phage inhibition, colicin resistance and tellurite resistance protein 1104638..1105213 Escherichia coli O157:H7 str. EDL933 958747 NP_286712.1 CDS terF NC_002655.2 1105635 1105943 D phage inhibition, colicin resistance and tellurite resistance protein 1105635..1105943 Escherichia coli O157:H7 str. EDL933 958749 NP_286713.1 CDS Z1178 NC_002655.2 1106535 1108625 R IrgA-homologue adhesin (Iha); TonB-dependent; acts as a specific receptor of enterobactin; fur-regulated; urovirulence factor; bifunctional enterobactin receptor/adhesin protein complement(1106535..1108625) Escherichia coli O157:H7 str. EDL933 958751 NP_286715.1 CDS Z1180 NC_002655.2 1109295 1109582 R No significant matches; hypothetical protein complement(1109295..1109582) Escherichia coli O157:H7 str. EDL933 958753 NP_286716.1 CDS Z1181 NC_002655.2 1110079 1110297 D hypothetical protein 1110079..1110297 Escherichia coli O157:H7 str. EDL933 958754 NP_286717.1 CDS Z1182 NC_002655.2 1110699 1110797 R No significant matches; hypothetical protein complement(1110699..1110797) Escherichia coli O157:H7 str. EDL933 958755 NP_286718.1 CDS Z1183 NC_002655.2 1110930 1111265 D hypothetical protein 1110930..1111265 Escherichia coli O157:H7 str. EDL933 958761 NP_286719.1 CDS Z1184 NC_002655.2 1111782 1111916 D No significant matches; hypothetical protein 1111782..1111916 Escherichia coli O157:H7 str. EDL933 958762 NP_286720.1 CDS Z1185 NC_002655.2 1112046 1112240 R No significant matches; hypothetical protein complement(1112046..1112240) Escherichia coli O157:H7 str. EDL933 958764 NP_286721.1 CDS Z1186 NC_002655.2 1112560 1112832 D No significant matches; hypothetical protein 1112560..1112832 Escherichia coli O157:H7 str. EDL933 958765 NP_286722.1 CDS Z1187 NC_002655.2 1113224 1113331 D No significant matches; hypothetical protein 1113224..1113331 Escherichia coli O157:H7 str. EDL933 958766 NP_286723.1 CDS Z1188 NC_002655.2 1113397 1113594 D No significant matches; hypothetical protein 1113397..1113594 Escherichia coli O157:H7 str. EDL933 958769 NP_286724.1 CDS Z1189 NC_002655.2 1113678 1113797 D No significant matches; hypothetical protein 1113678..1113797 Escherichia coli O157:H7 str. EDL933 958771 NP_286725.1 CDS Z1190 NC_002655.2 1114324 1115448 D glucosyltransferase 1114324..1115448 Escherichia coli O157:H7 str. EDL933 958772 NP_286726.1 CDS Z1191 NC_002655.2 1115590 1115865 R hypothetical protein complement(1115590..1115865) Escherichia coli O157:H7 str. EDL933 958776 NP_286727.1 CDS Z1192 NC_002655.2 1115867 1116370 R IS1 protein InsB complement(1115867..1116370) Escherichia coli O157:H7 str. EDL933 958777 NP_286728.1 CDS Z1193 NC_002655.2 1116802 1117272 R No significant matches; hypothetical protein complement(1116802..1117272) Escherichia coli O157:H7 str. EDL933 958778 NP_286729.1 CDS Z1194 NC_002655.2 1117718 1118227 D No significant matches; hypothetical protein 1117718..1118227 Escherichia coli O157:H7 str. EDL933 958779 NP_286730.1 CDS Z1195 NC_002655.2 1118316 1118939 D No significant matches; hypothetical protein 1118316..1118939 Escherichia coli O157:H7 str. EDL933 958780 NP_286731.1 CDS Z1196 NC_002655.2 1119035 1119268 D No significant matches; hypothetical protein 1119035..1119268 Escherichia coli O157:H7 str. EDL933 958781 NP_286732.1 CDS Z1197 NC_002655.2 1119321 1119512 R No significant matches; hypothetical protein complement(1119321..1119512) Escherichia coli O157:H7 str. EDL933 958782 NP_286733.1 CDS Z1198 NC_002655.2 1120106 1120993 R transposase complement(1120106..1120993) Escherichia coli O157:H7 str. EDL933 958784 NP_286734.1 CDS Z1199 NC_002655.2 1120993 1121319 R hypothetical protein complement(1120993..1121319) Escherichia coli O157:H7 str. EDL933 958785 NP_286735.1 CDS Z1200 NC_002655.2 1121500 1122546 D hypothetical protein 1121500..1122546 Escherichia coli O157:H7 str. EDL933 958787 NP_286736.1 CDS Z1201 NC_002655.2 1122787 1123302 D No significant matches; hypothetical protein 1122787..1123302 Escherichia coli O157:H7 str. EDL933 958788 NP_286737.1 CDS Z1202 NC_002655.2 1123332 1125467 D hypothetical protein 1123332..1125467 Escherichia coli O157:H7 str. EDL933 958789 NP_286738.1 CDS Z1203 NC_002655.2 1125968 1127200 D hypothetical protein 1125968..1127200 Escherichia coli O157:H7 str. EDL933 958792 NP_286739.1 CDS Z1204 NC_002655.2 1127185 1127823 D hypothetical protein 1127185..1127823 Escherichia coli O157:H7 str. EDL933 958793 NP_286740.1 CDS Z1205 NC_002655.2 1128192 1128836 D No significant matches; hypothetical protein 1128192..1128836 Escherichia coli O157:H7 str. EDL933 958794 NP_286741.1 CDS Z1206 NC_002655.2 1128884 1129039 D No significant matches; hypothetical protein 1128884..1129039 Escherichia coli O157:H7 str. EDL933 958795 NP_286742.1 CDS Z1207 NC_002655.2 1129534 1129782 R hypothetical protein complement(1129534..1129782) Escherichia coli O157:H7 str. EDL933 958796 NP_286743.1 CDS Z1208 NC_002655.2 1129836 1130261 D hypothetical protein 1129836..1130261 Escherichia coli O157:H7 str. EDL933 958799 NP_286744.1 CDS Z1209 NC_002655.2 1130561 1130743 R No significant matches; hypothetical protein complement(1130561..1130743) Escherichia coli O157:H7 str. EDL933 958800 NP_286745.1 CDS Z1210 NC_002655.2 1131072 1131944 D histone 1131072..1131944 Escherichia coli O157:H7 str. EDL933 958806 NP_286746.1 CDS Z1211 NC_002655.2 1132148 1135165 D adhesin 1132148..1135165 Escherichia coli O157:H7 str. EDL933 958808 NP_286747.1 CDS Z1212 NC_002655.2 1135273 1137660 D hypothetical protein 1135273..1137660 Escherichia coli O157:H7 str. EDL933 958809 NP_286748.1 CDS Z1213 NC_002655.2 1137657 1138562 D hypothetical protein 1137657..1138562 Escherichia coli O157:H7 str. EDL933 958810 NP_286749.1 CDS Z1214 NC_002655.2 1138559 1139629 D hypothetical protein 1138559..1139629 Escherichia coli O157:H7 str. EDL933 958812 NP_286750.1 CDS Z1215 NC_002655.2 1139969 1140787 D hypothetical protein 1139969..1140787 Escherichia coli O157:H7 str. EDL933 958815 NP_286751.1 CDS Z1216 NC_002655.2 1140878 1141363 D hypothetical protein 1140878..1141363 Escherichia coli O157:H7 str. EDL933 958816 NP_286752.1 CDS Z1217 NC_002655.2 1141379 1141855 D RadC family DNA repair protein 1141379..1141855 Escherichia coli O157:H7 str. EDL933 958817 NP_286753.1 CDS Z1218 NC_002655.2 1141918 1142139 D hypothetical protein 1141918..1142139 Escherichia coli O157:H7 str. EDL933 958819 NP_286754.1 CDS Z1219 NC_002655.2 1142139 1142252 D No significant matches; hypothetical protein 1142139..1142252 Escherichia coli O157:H7 str. EDL933 958820 NP_286755.1 CDS Z1220 NC_002655.2 1142302 1142676 D structural protein 1142302..1142676 Escherichia coli O157:H7 str. EDL933 958821 NP_286756.1 CDS Z1221 NC_002655.2 1142979 1143866 R transposase complement(1142979..1143866) Escherichia coli O157:H7 str. EDL933 958822 NP_286757.1 CDS Z1222 NC_002655.2 1143866 1144192 R hypothetical protein complement(1143866..1144192) Escherichia coli O157:H7 str. EDL933 958825 NP_286758.1 CDS Z1223 NC_002655.2 1144407 1144898 D hypothetical protein 1144407..1144898 Escherichia coli O157:H7 str. EDL933 958829 NP_286759.1 CDS Z1225 NC_002655.2 1144910 1145107 D hypothetical protein 1144910..1145107 Escherichia coli O157:H7 str. EDL933 958835 NP_286760.1 CDS Z1226 NC_002655.2 1145192 1146034 D hypothetical protein 1145192..1146034 Escherichia coli O157:H7 str. EDL933 958836 NP_286761.1 CDS infA NC_002655.2 1146525 1146743 R stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 complement(1146525..1146743) Escherichia coli O157:H7 str. EDL933 958838 NP_286762.1 CDS aat NC_002655.2 1147028 1147732 R leucyltransferase; phenylalanyltransferse; functions in the N-end rule pathway; transfers Leu, Phe, Met, from aminoacyl-tRNAs to N-terminal of proteins with Arg or Lys; leucyl/phenylalanyl-tRNA--protein transferase complement(1147028..1147732) Escherichia coli O157:H7 str. EDL933 958840 NP_286763.1 CDS cydC NC_002655.2 1147774 1149495 R in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding protein complement(1147774..1149495) Escherichia coli O157:H7 str. EDL933 958841 NP_286764.1 CDS cydD NC_002655.2 1149496 1151262 R in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding protein complement(1149496..1151262) Escherichia coli O157:H7 str. EDL933 958845 NP_286765.1 CDS trxB NC_002655.2 1151385 1152350 R catalyzes the transfer of electrons from NADPH to thioredoxin; FAD/NAD(P) binding; thioredoxin reductase complement(1151385..1152350) Escherichia coli O157:H7 str. EDL933 958846 NP_286766.1 CDS lrp NC_002655.2 1152895 1153389 D mediates a global response to leucine; acts as a regulator for several genes involved in the high-affinity branched-chain amino acid transport system; leucine-responsive transcriptional regulator 1152895..1153389 Escherichia coli O157:H7 str. EDL933 958847 NP_286767.1 CDS ftsK NC_002655.2 1153524 1157552 D DNA-binding membrane protein required for chromosome resolution and partitioning; DNA translocase FtsK 1153524..1157552 Escherichia coli O157:H7 str. EDL933 958848 NP_286768.1 CDS lolA NC_002655.2 1157704 1158318 D participates with LolB in the incorporation of lipoprotein into the outer membrane; outer-membrane lipoprotein carrier protein 1157704..1158318 Escherichia coli O157:H7 str. EDL933 958850 NP_286769.1 CDS ycaJ NC_002655.2 1158329 1159672 D recombination factor protein RarA 1158329..1159672 Escherichia coli O157:H7 str. EDL933 958851 NP_286770.1 CDS serS NC_002655.2 1159763 1161055 D catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 1159763..1161055 Escherichia coli O157:H7 str. EDL933 958852 NP_286771.1 CDS dmsA NC_002655.2 1161381 1163738 D anaerobic dimethyl sulfoxide reductase subunit A 1161381..1163738 Escherichia coli O157:H7 str. EDL933 958853 NP_286772.1 CDS dmsB NC_002655.2 1163749 1164366 D anaerobic dimethyl sulfoxide reductase subunit B 1163749..1164366 Escherichia coli O157:H7 str. EDL933 958857 NP_286773.1 CDS dmsC NC_002655.2 1164368 1165231 D anaerobic dimethyl sulfoxide reductase subunit C 1164368..1165231 Escherichia coli O157:H7 str. EDL933 958858 NP_286774.1 CDS ycaC NC_002655.2 1165267 1165893 R hypothetical protein complement(1165267..1165893) Escherichia coli O157:H7 str. EDL933 958860 NP_286775.1 CDS ycaD NC_002655.2 1166208 1167356 D MFS family transporter protein 1166208..1167356 Escherichia coli O157:H7 str. EDL933 958861 NP_286776.1 CDS Z1245 NC_002655.2 1167374 1168996 D transport 1167374..1168996 Escherichia coli O157:H7 str. EDL933 958862 NP_286777.1 CDS pflA NC_002655.2 1169206 1169946 R activates pyruvate formate-lyase 1 under anaerobic conditions; pyruvate formate lyase-activating enzyme 1 complement(1169206..1169946) Escherichia coli O157:H7 str. EDL933 958863 NP_286778.1 CDS pflB NC_002655.2 1170138 1172420 R formate acetyltransferase 1 complement(1170138..1172420) Escherichia coli O157:H7 str. EDL933 958864 NP_286779.1 CDS focA NC_002655.2 1172475 1173332 R formate transporter complement(1172475..1173332) Escherichia coli O157:H7 str. EDL933 958866 NP_286780.1 CDS ycaO NC_002655.2 1173738 1175507 R hypothetical protein complement(1173738..1175507) Escherichia coli O157:H7 str. EDL933 958867 NP_286781.1 CDS ycaP NC_002655.2 1175628 1176320 D hypothetical protein 1175628..1176320 Escherichia coli O157:H7 str. EDL933 958868 NP_286782.1 CDS serC NC_002655.2 1176519 1177607 D catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine; phosphoserine aminotransferase 1176519..1177607 Escherichia coli O157:H7 str. EDL933 958869 NP_286783.1 CDS aroA NC_002655.2 1177678 1178961 D catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase 1177678..1178961 Escherichia coli O157:H7 str. EDL933 958870 NP_286784.1 CDS ycaL NC_002655.2 1179106 1179894 D heat shock protein 1179106..1179894 Escherichia coli O157:H7 str. EDL933 958871 NP_286785.1 CDS cmk NC_002655.2 1180067 1180750 D Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase 1180067..1180750 Escherichia coli O157:H7 str. EDL933 958872 NP_286786.1 CDS rpsA NC_002655.2 1180861 1182534 D in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 1180861..1182534 Escherichia coli O157:H7 str. EDL933 958873 NP_286787.1 CDS ihfB NC_002655.2 1182694 1182978 D This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit beta 1182694..1182978 Escherichia coli O157:H7 str. EDL933 958874 NP_286788.2 CDS ycaI NC_002655.2 1183185 1185449 D hypothetical protein 1183185..1185449 Escherichia coli O157:H7 str. EDL933 958876 NP_286789.1 CDS msbA NC_002655.2 1185486 1187234 D involved in the transport of lipid A across the inner membrane; lipid transporter ATP-binding protein/permease 1185486..1187234 Escherichia coli O157:H7 str. EDL933 958877 NP_286790.1 CDS lpxK NC_002655.2 1187231 1188217 D transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate; tetraacyldisaccharide 4'-kinase 1187231..1188217 Escherichia coli O157:H7 str. EDL933 958878 NP_286791.1 CDS ycaQ NC_002655.2 1188254 1189486 D hypothetical protein 1188254..1189486 Escherichia coli O157:H7 str. EDL933 958879 NP_286792.1 CDS ycaR NC_002655.2 1189538 1189720 D hypothetical protein 1189538..1189720 Escherichia coli O157:H7 str. EDL933 958880 NP_286793.1 CDS kdsB NC_002655.2 1189717 1190463 D CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS; 3-deoxy-manno-octulosonate cytidylyltransferase 1189717..1190463 Escherichia coli O157:H7 str. EDL933 958882 NP_286794.1 CDS Z1265 NC_002655.2 1190617 1191510 D hypothetical protein 1190617..1191510 Escherichia coli O157:H7 str. EDL933 958883 NP_286795.1 CDS ycbC NC_002655.2 1191487 1192266 R hypothetical protein complement(1191487..1192266) Escherichia coli O157:H7 str. EDL933 958886 NP_286796.1 CDS smtA NC_002655.2 1192402 1193187 D involved in cellular zinc and cadmium homeostasis by binding excess metal ions to its cysteine sulfurs and histidine nitrogens; expression of smtA in cyanobacteria is repressed by SmtB at low concentrations of zinc; NO elicits release of Zn ions from SmtA; metallothionein SmtA 1192402..1193187 Escherichia coli O157:H7 str. EDL933 958887 NP_286797.1 CDS mukF NC_002655.2 1193184 1194506 D acts with MukB and MukE to condense the chromosome and allow for segregation during cell division; condesin subunit F 1193184..1194506 Escherichia coli O157:H7 str. EDL933 958891 NP_286798.1 CDS mukE NC_002655.2 1194514 1195191 D acts with MukB and MukF to condense the chromosome and allow for segregation during cell division; condesin subunit E 1194514..1195191 Escherichia coli O157:H7 str. EDL933 958893 NP_286799.1 CDS mukB NC_002655.2 1195191 1199651 D SMC (structural maintenance of chromosomes) family of proteins; involved in chromosome condensatin and partitioning; forms a homodimer and the C-terminal is essential for DNA-binding activity while the purified N-terminal domain binds FtsZ; mutations result in cell division defects; cell division protein MukB 1195191..1199651 Escherichia coli O157:H7 str. EDL933 958894 NP_286800.1 CDS ycbB NC_002655.2 1199912 1201759 D hypothetical protein 1199912..1201759 Escherichia coli O157:H7 str. EDL933 958895 NP_286801.1 CDS ycbK NC_002655.2 1201940 1202488 D hypothetical protein 1201940..1202488 Escherichia coli O157:H7 str. EDL933 958899 NP_286802.1 CDS ycbL NC_002655.2 1202515 1203162 D hypothetical protein 1202515..1203162 Escherichia coli O157:H7 str. EDL933 958903 NP_286803.1 CDS aspC NC_002655.2 1203213 1204403 R catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate; aromatic amino acid aminotransferase complement(1203213..1204403) Escherichia coli O157:H7 str. EDL933 958904 NP_286804.1 CDS ompF NC_002655.2 1204588 1205676 R outer membrane porin F; 1a; Ia; b; outer membrane protein F complement(1204588..1205676) Escherichia coli O157:H7 str. EDL933 958905 NP_286805.1 CDS asnC NC_002655.2 1206279 1207679 R catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; asparaginyl-tRNA synthetase complement(1206279..1207679) Escherichia coli O157:H7 str. EDL933 958907 NP_286806.1 CDS pncB NC_002655.2 1207848 1209050 R catalyzes the formation of nictonate and 5-phospho-alpha-D-ribose 1-diphosphate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase complement(1207848..1209050) Escherichia coli O157:H7 str. EDL933 958910 NP_286807.1 CDS pepN NC_002655.2 1209316 1211928 D aminopeptidase 1209316..1211928 Escherichia coli O157:H7 str. EDL933 958912 NP_286808.1 CDS ssuB NC_002655.2 1211971 1212738 R part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic substrate-binding subunit, SsuB the ATP-binding subunit and SsuC the permease; aliphatic sulfonates transport ATP-binding subunit complement(1211971..1212738) Escherichia coli O157:H7 str. EDL933 958914 NP_286809.1 CDS ssuC NC_002655.2 1212735 1213526 R part of the ABC type transport system for alkanesulfonate SsuABC; SsuB the ATP-binding subunit and SsuC the permease; alkanesulfonate transporter permease complement(1212735..1213526) Escherichia coli O157:H7 str. EDL933 958915 NP_286810.1 CDS ycbN NC_002655.2 1213538 1214683 R catalyzes the release of sulfite from alkanesulfonates; alkanesulfonate monooxygenase complement(1213538..1214683) Escherichia coli O157:H7 str. EDL933 958916 NP_286811.2 CDS ycbO NC_002655.2 1214680 1215639 R part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic subunit SsuB the ATP-binding subunit and SsuC the permease; alkanesulfonate transporter substrate-binding subunit complement(1214680..1215639) Escherichia coli O157:H7 str. EDL933 958917 NP_286812.1 CDS ycbP NC_002655.2 1215632 1216207 R NAD(P)H-dependent FMN reductase complement(1215632..1216207) Escherichia coli O157:H7 str. EDL933 958918 NP_286813.1 CDS ycbQ NC_002655.2 1216554 1217102 D fimbrial-like protein 1216554..1217102 Escherichia coli O157:H7 str. EDL933 958919 NP_286814.1 CDS ycbR NC_002655.2 1217185 1217886 D chaperone 1217185..1217886 Escherichia coli O157:H7 str. EDL933 958920 NP_286815.1 CDS Z1288m NC_002655.2 1217911 1220510 D PapC-like porin protein involved in fimbrial biogenesis join(1217911..1218402,1218402..1220510) Escherichia coli O157:H7 str. EDL933 959649 NP_286816.1 CDS Z1290 NC_002655.2 1220501 1221481 D fimbrial protein 1220501..1221481 Escherichia coli O157:H7 str. EDL933 958921 NP_286817.1 CDS Z1291 NC_002655.2 1221650 1222126 D hypothetical protein 1221650..1222126 Escherichia coli O157:H7 str. EDL933 958922 NP_286818.1 CDS Z1292 NC_002655.2 1222086 1222649 D fimbrial-like protein 1222086..1222649 Escherichia coli O157:H7 str. EDL933 958924 NP_286819.1 CDS ycbF NC_002655.2 1222615 1223351 D pili assembly chaperone join(1222615..1223085,1223085..1223351) Escherichia coli O157:H7 str. EDL933 959630 NP_286820.1 CDS pyrD NC_002655.2 1223462 1224472 D catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors; dihydroorotate dehydrogenase 2 1223462..1224472 Escherichia coli O157:H7 str. EDL933 958925 NP_286821.1 CDS ycbW NC_002655.2 1224610 1225188 D hypothetical protein 1224610..1225188 Escherichia coli O157:H7 str. EDL933 958929 NP_286822.1 CDS Z1297 NC_002655.2 1225185 1226294 R hypothetical protein complement(1225185..1226294) Escherichia coli O157:H7 str. EDL933 958930 NP_286823.1 CDS rlmL NC_002655.2 1226538 1228646 D catalyzes the N2-methyl guanosine modification of the G2445 residue of 23S rRNA; 23S rRNA m(2)G2445 methyltransferase 1226538..1228646 Escherichia coli O157:H7 str. EDL933 958931 NP_286824.1 CDS uup NC_002655.2 1228658 1230565 D Uup; in Escherichia coli this cytoplasmic protein was shown to contain ATPase activity; mutations in this gene affect RecA-independent excision of transposons and affects Mu bacteriophage growth; ABC transporter ATPase 1228658..1230565 Escherichia coli O157:H7 str. EDL933 958932 NP_286825.1 CDS pqiA NC_002655.2 1230695 1231948 D paraquat-inducible protein A 1230695..1231948 Escherichia coli O157:H7 str. EDL933 958933 NP_286826.1 CDS pqiB NC_002655.2 1231953 1233593 D paraquat-inducible protein B 1231953..1233593 Escherichia coli O157:H7 str. EDL933 958934 NP_286827.1 CDS ymbA NC_002655.2 1233605 1234153 D hypothetical protein 1233605..1234153 Escherichia coli O157:H7 str. EDL933 958935 NP_286828.1 CDS rmf NC_002655.2 1234409 1234576 D ribosome modulation factor 1234409..1234576 Escherichia coli O157:H7 str. EDL933 958936 NP_286829.1 CDS fabA NC_002655.2 1234646 1235164 R catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP; 3-hydroxydecanoyl-ACP dehydratase complement(1234646..1235164) Escherichia coli O157:H7 str. EDL933 958939 NP_286830.1 CDS Z1305 NC_002655.2 1235233 1236993 R ATP-dependent protease complement(1235233..1236993) Escherichia coli O157:H7 str. EDL933 958940 NP_286831.1 CDS ycbG NC_002655.2 1237179 1237631 D hypothetical protein 1237179..1237631 Escherichia coli O157:H7 str. EDL933 958945 NP_286832.1 CDS ompA NC_002655.2 1237707 1238747 R OmpA is believed to be a porin, involved in diffusion of nonspecific small solutes across the outer membrane. It is the most abundant integral protein of the outer membrane of E. coli, and it is known to play a role as a phage receptor, a mediator of F-factor dependent conjugation, and in maintaining the structural shape of the outer membrane; 3a; II*; G; d; outer membrane protein OmpA complement(1237707..1238747) Escherichia coli O157:H7 str. EDL933 958948 NP_286833.1 CDS sulA NC_002655.2 1239104 1239613 R SOS cell division inhibitor complement(1239104..1239613) Escherichia coli O157:H7 str. EDL933 958949 NP_286834.1 CDS Z1309 NC_002655.2 1239832 1240461 D hypothetical protein 1239832..1240461 Escherichia coli O157:H7 str. EDL933 958950 NP_286835.1 CDS Z1311 NC_002655.2 1240424 1242586 R hypothetical protein complement(1240424..1242586) Escherichia coli O157:H7 str. EDL933 958951 NP_286836.1 CDS yccF NC_002655.2 1242596 1243042 R hypothetical protein complement(1242596..1243042) Escherichia coli O157:H7 str. EDL933 958952 NP_286837.1 CDS helD NC_002655.2 1243165 1245219 D catalyzes the ATP-dependent unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand; DNA helicase IV 1243165..1245219 Escherichia coli O157:H7 str. EDL933 958954 NP_286838.2 CDS mgsA NC_002655.2 1245251 1245709 R catalyzes the formation of methylglyoxal from glycerone phosphate; methylglyoxal synthase complement(1245251..1245709) Escherichia coli O157:H7 str. EDL933 958955 NP_286839.1 CDS Z1315 NC_002655.2 1245805 1246467 R hypothetical protein complement(1245805..1246467) Escherichia coli O157:H7 str. EDL933 958959 NP_286840.1 CDS Z1317 NC_002655.2 1246640 1247053 D hypothetical protein 1246640..1247053 Escherichia coli O157:H7 str. EDL933 958960 NP_286841.1 CDS yccV NC_002655.2 1247098 1247466 R heat shock protein HspQ complement(1247098..1247466) Escherichia coli O157:H7 str. EDL933 958962 NP_286842.1 CDS Z1319 NC_002655.2 1247473 1248576 R oxidoreductase complement(1247473..1248576) Escherichia coli O157:H7 str. EDL933 958963 NP_286843.1 CDS Z1320 NC_002655.2 1248758 1249036 D catalyzes the hydrolysis of acylphosphate; acylphosphatase 1248758..1249036 Escherichia coli O157:H7 str. EDL933 958964 NP_286844.2 CDS yccK NC_002655.2 1249033 1249362 R transfers sulfur from TusBCD complex to MnmA; involved in thiouridation of U34 position of some tRNAs; sulfur transfer protein TusE complement(1249033..1249362) Escherichia coli O157:H7 str. EDL933 958965 NP_286845.1 CDS yccA NC_002655.2 1249453 1250112 R hypothetical protein complement(1249453..1250112) Escherichia coli O157:H7 str. EDL933 958966 NP_286846.1 CDS Z1323 NC_002655.2 1250521 1251540 R integrase for cryptic prophage CP-933M complement(1250521..1251540) Escherichia coli O157:H7 str. EDL933 958967 NP_286847.1 CDS Z1324 NC_002655.2 1251828 1254299 R exodeoxyribonuclease VIII complement(1251828..1254299) Escherichia coli O157:H7 str. EDL933 958968 NP_286848.1 CDS Z1325 NC_002655.2 1254393 1254584 R hypothetical protein complement(1254393..1254584) Escherichia coli O157:H7 str. EDL933 958969 NP_286849.1 CDS Z1326 NC_002655.2 1254581 1254769 R inhibitor of cell division encoded by cryptic prophage CP-933M complement(1254581..1254769) Escherichia coli O157:H7 str. EDL933 958970 NP_286850.1 CDS Z1328 NC_002655.2 1255272 1255529 D No significant matches; hypothetical protein 1255272..1255529 Escherichia coli O157:H7 str. EDL933 958973 NP_286851.1 CDS Z1329 NC_002655.2 1255716 1256105 R No significant matches; hypothetical protein complement(1255716..1256105) Escherichia coli O157:H7 str. EDL933 958974 NP_286852.1 CDS Z1330 NC_002655.2 1256117 1256254 R hypothetical protein complement(1256117..1256254) Escherichia coli O157:H7 str. EDL933 958975 NP_286853.1 CDS Z1331 NC_002655.2 1256247 1256402 R hypothetical protein complement(1256247..1256402) Escherichia coli O157:H7 str. EDL933 958976 NP_286854.1 CDS Z1332 NC_002655.2 1256967 1257158 R No significant matches; hypothetical protein complement(1256967..1257158) Escherichia coli O157:H7 str. EDL933 958977 NP_286855.1 CDS Z1333 NC_002655.2 1257186 1257584 R DicA, regulator of DicB; encoded within cryptic prophage CP-933M complement(1257186..1257584) Escherichia coli O157:H7 str. EDL933 958978 NP_286856.1 CDS Z1334 NC_002655.2 1257696 1257968 D No significant matches; hypothetical protein 1257696..1257968 Escherichia coli O157:H7 str. EDL933 958979 NP_286857.1 CDS Z1335 NC_002655.2 1257952 1258377 D hypothetical protein 1257952..1258377 Escherichia coli O157:H7 str. EDL933 958980 NP_286858.1 CDS Z1336 NC_002655.2 1258343 1258900 D No significant matches; hypothetical protein 1258343..1258900 Escherichia coli O157:H7 str. EDL933 958981 NP_286859.1 CDS Z1337 NC_002655.2 1259007 1260209 D No significant matches; hypothetical protein 1259007..1260209 Escherichia coli O157:H7 str. EDL933 958982 NP_286860.1 CDS Z1338 NC_002655.2 1260216 1260962 D acts to load the DnaB helicase onto the intiation site durning DNA replication; replication protein 1260216..1260962 Escherichia coli O157:H7 str. EDL933 958983 NP_286861.1 CDS Z1339 NC_002655.2 1260984 1261754 D hypothetical protein 1260984..1261754 Escherichia coli O157:H7 str. EDL933 958984 NP_286862.1 CDS Z1340 NC_002655.2 1261770 1262183 D No significant matches; hypothetical protein 1261770..1262183 Escherichia coli O157:H7 str. EDL933 958985 NP_286863.1 CDS Z1341 NC_002655.2 1262535 1263308 R hypothetical protein complement(1262535..1263308) Escherichia coli O157:H7 str. EDL933 958986 NP_286864.1 CDS Z1342 NC_002655.2 1263856 1264068 D cell killing protein encoded within cryptic prophage CP-933M 1263856..1264068 Escherichia coli O157:H7 str. EDL933 958987 NP_286865.1 CDS Z1343 NC_002655.2 1264516 1265565 D hypothetical protein 1264516..1265565 Escherichia coli O157:H7 str. EDL933 958988 NP_286866.1 CDS Z1344 NC_002655.2 1265578 1265952 D endonuclease of cryptic prophage CP-933M 1265578..1265952 Escherichia coli O157:H7 str. EDL933 958989 NP_286867.1 CDS Z1345 NC_002655.2 1265949 1266770 D antitermination protein Q 1265949..1266770 Escherichia coli O157:H7 str. EDL933 958990 NP_286869.1 CDS Z1347 NC_002655.2 1267098 1267370 D No significant matches; hypothetical protein 1267098..1267370 Escherichia coli O157:H7 str. EDL933 958992 NP_286870.1 CDS Z1348 NC_002655.2 1267367 1267534 D No significant matches; hypothetical protein 1267367..1267534 Escherichia coli O157:H7 str. EDL933 958993 NP_286871.1 CDS Z1349 NC_002655.2 1267849 1269699 D hypothetical protein 1267849..1269699 Escherichia coli O157:H7 str. EDL933 958994 NP_286872.1 CDS Z1350 NC_002655.2 1270148 1270354 D holin protein of cryptic prophage CP-933M 1270148..1270354 Escherichia coli O157:H7 str. EDL933 958995 NP_286873.1 CDS Z1351 NC_002655.2 1270356 1270703 D hypothetical protein 1270356..1270703 Escherichia coli O157:H7 str. EDL933 958996 NP_286874.1 CDS Z1352 NC_002655.2 1270754 1271104 D endolysin of cryptic prophage CP-933M 1270754..1271104 Escherichia coli O157:H7 str. EDL933 958997 NP_286875.1 CDS Z1353 NC_002655.2 1271559 1272128 D antirepressor protein of cryptic prophage CP-933M 1271559..1272128 Escherichia coli O157:H7 str. EDL933 958998 NP_286876.1 CDS Z1354 NC_002655.2 1272282 1272749 D endopeptidase of cryptic prophage CP-933M 1272282..1272749 Escherichia coli O157:H7 str. EDL933 959000 NP_286877.1 CDS Z1355 NC_002655.2 1273112 1273339 R hypothetical protein complement(1273112..1273339) Escherichia coli O157:H7 str. EDL933 959001 NP_286878.1 CDS Z1356 NC_002655.2 1273463 1273747 D No significant matches; hypothetical protein 1273463..1273747 Escherichia coli O157:H7 str. EDL933 959002 NP_286879.1 CDS Z1357 NC_002655.2 1274037 1274600 D No significant matches; hypothetical protein 1274037..1274600 Escherichia coli O157:H7 str. EDL933 959003 NP_286880.1 CDS Z1358 NC_002655.2 1274597 1275853 D hypothetical protein 1274597..1275853 Escherichia coli O157:H7 str. EDL933 959004 NP_286881.1 CDS Z1359 NC_002655.2 1275708 1276259 D hypothetical protein 1275708..1276259 Escherichia coli O157:H7 str. EDL933 959005 NP_286882.1 CDS Z1360 NC_002655.2 1276323 1278260 D hypothetical protein 1276323..1278260 Escherichia coli O157:H7 str. EDL933 959006 NP_286883.1 CDS Z1361 NC_002655.2 1278305 1278526 D No significant matches; hypothetical protein 1278305..1278526 Escherichia coli O157:H7 str. EDL933 959007 NP_286884.1 CDS Z1362 NC_002655.2 1278472 1279017 D No significant matches; hypothetical protein 1278472..1279017 Escherichia coli O157:H7 str. EDL933 959008 NP_286885.1 CDS Z1363 NC_002655.2 1279288 1279839 D hypothetical protein 1279288..1279839 Escherichia coli O157:H7 str. EDL933 959009 NP_286886.1 CDS Z1364 NC_002655.2 1279836 1280240 D No significant matches; hypothetical protein 1279836..1280240 Escherichia coli O157:H7 str. EDL933 959010 NP_286887.1 CDS Z1365 NC_002655.2 1280274 1281224 D No significant matches; hypothetical protein 1280274..1281224 Escherichia coli O157:H7 str. EDL933 959011 NP_286888.1 CDS Z1366 NC_002655.2 1281221 1281547 D No significant matches; hypothetical protein 1281221..1281547 Escherichia coli O157:H7 str. EDL933 959012 NP_286889.1 CDS Z1367 NC_002655.2 1281704 1281907 D hypothetical protein 1281704..1281907 Escherichia coli O157:H7 str. EDL933 959013 NP_286890.1 CDS Z1368 NC_002655.2 1281904 1282350 D hypothetical protein 1281904..1282350 Escherichia coli O157:H7 str. EDL933 959014 NP_286891.1 CDS Z1369 NC_002655.2 1282347 1282691 D hypothetical protein 1282347..1282691 Escherichia coli O157:H7 str. EDL933 959015 NP_286892.1 CDS Z1370 NC_002655.2 1282688 1283467 D tail component encoded by cryptic prophage CP-933M 1282688..1283467 Escherichia coli O157:H7 str. EDL933 959016 NP_286893.1 CDS Z1371 NC_002655.2 1283473 1283847 D tail assembly chaperone encoded by cryptic prophage CP-933M 1283473..1283847 Escherichia coli O157:H7 str. EDL933 959017 NP_286894.1 CDS Z1372 NC_002655.2 1283871 1284152 D hypothetical protein 1283871..1284152 Escherichia coli O157:H7 str. EDL933 959018 NP_286895.1 CDS Z1373 NC_002655.2 1284423 1285205 D hypothetical protein 1284423..1285205 Escherichia coli O157:H7 str. EDL933 959019 NP_286896.1 CDS Z1374 NC_002655.2 1285072 1285407 D hypothetical protein 1285072..1285407 Escherichia coli O157:H7 str. EDL933 959020 NP_286897.1 CDS Z1375 NC_002655.2 1285628 1286059 D tail component encoded by cryptic prophage CP-933M; partial 1285628..1286059 Escherichia coli O157:H7 str. EDL933 959021 NP_286898.1 CDS Z1376 NC_002655.2 1286065 1286235 D tail component encoded by cryptic prophage CP-933M; partial 1286065..1286235 Escherichia coli O157:H7 str. EDL933 959022 NP_286899.1 CDS Z1377 NC_002655.2 1286409 1286927 D tail component encoded by cryptic prophage CP-933M 1286409..1286927 Escherichia coli O157:H7 str. EDL933 959023 NP_286900.1 CDS Z1378 NC_002655.2 1286761 1287663 D tail component encoded by cryptic prophage CP-933M; partial 1286761..1287663 Escherichia coli O157:H7 str. EDL933 959024 NP_286901.1 CDS Z1379 NC_002655.2 1288074 1289009 D tail component encoded by cryptic prophage CP-933M; partial 1288074..1289009 Escherichia coli O157:H7 str. EDL933 959025 NP_286902.1 CDS Z1380 NC_002655.2 1289061 1291484 D tail component encoded by cryptic prophage CP-933M; partial 1289061..1291484 Escherichia coli O157:H7 str. EDL933 959026 NP_286903.1 CDS Z1381 NC_002655.2 1291552 1292151 D outer membrane protein Lom encoded by cryptic prophage CP-933M 1291552..1292151 Escherichia coli O157:H7 str. EDL933 959028 NP_286904.1 CDS Z1382 NC_002655.2 1292210 1293337 D tail component encoded by cryptic prophage CP-933M; partial 1292210..1293337 Escherichia coli O157:H7 str. EDL933 959029 NP_286905.1 CDS Z1383 NC_002655.2 1293413 1293802 D hypothetical protein 1293413..1293802 Escherichia coli O157:H7 str. EDL933 959030 NP_286906.1 CDS Z1385 NC_002655.2 1293927 1294679 R hypothetical protein complement(1293927..1294679) Escherichia coli O157:H7 str. EDL933 959031 NP_286907.1 CDS Z1386 NC_002655.2 1295011 1295127 D No significant matches; hypothetical protein 1295011..1295127 Escherichia coli O157:H7 str. EDL933 959032 NP_286908.1 CDS Z1387 NC_002655.2 1295276 1295458 R hypothetical protein complement(1295276..1295458) Escherichia coli O157:H7 str. EDL933 959033 NP_286909.1 CDS hyaA NC_002655.2 1296076 1297194 D hydrogenase-1 small subunit 1296076..1297194 Escherichia coli O157:H7 str. EDL933 959035 NP_286910.1 CDS hyaB NC_002655.2 1297191 1298984 D involved in hydrogen cycling during fermentative growth; hydrogenase 1 large subunit 1297191..1298984 Escherichia coli O157:H7 str. EDL933 959036 NP_286911.1 CDS hyaC NC_002655.2 1299003 1299710 D hydrogenase 1 b-type cytochrome subunit 1299003..1299710 Escherichia coli O157:H7 str. EDL933 959037 NP_286912.1 CDS hyaD NC_002655.2 1299707 1300294 D HyaD; endopeptidase involved in the cleavage of the C-terminus end of HyaB (the large subunit of hydrogenase 1); hydrogenase 1 maturation protease 1299707..1300294 Escherichia coli O157:H7 str. EDL933 959038 NP_286913.1 CDS hyaE NC_002655.2 1300291 1300689 D involved in processing hydrogenases HyaA and HyaB; hydrogenase-1 operon protein HyaE 1300291..1300689 Escherichia coli O157:H7 str. EDL933 959040 NP_286914.1 CDS hyaF NC_002655.2 1300686 1301543 D hydrogenase-1 operon protein HyaF 1300686..1301543 Escherichia coli O157:H7 str. EDL933 959041 NP_286915.1 CDS appC NC_002655.2 1301677 1303221 D third cytochrome oxidase, subunit I 1301677..1303221 Escherichia coli O157:H7 str. EDL933 959042 NP_286916.1 CDS appB NC_002655.2 1303233 1304369 D third cytochrome oxidase, subunit II 1303233..1304369 Escherichia coli O157:H7 str. EDL933 959043 NP_286917.1 CDS appA NC_002655.2 1304524 1305858 D phosphoanhydride phosphorylase 1304524..1305858 Escherichia coli O157:H7 str. EDL933 959044 NP_286918.1 CDS yccC NC_002655.2 1305978 1308158 R cryptic autophosphorylating protein tyrosine kinase Etk complement(1305978..1308158) Escherichia coli O157:H7 str. EDL933 959045 NP_286919.2 CDS etp NC_002655.2 1308178 1308624 R Etk and Etp are a tyrosine kinase-tyrosine phosphatase pair, etp dephosphorylates etk; phosphotyrosine-protein phosphatase complement(1308178..1308624) Escherichia coli O157:H7 str. EDL933 959046 NP_286920.1 CDS yccZ NC_002655.2 1308612 1309751 R function in exopolysaccharide production complement(1308612..1309751) Escherichia coli O157:H7 str. EDL933 959047 NP_286921.1 CDS ymcA NC_002655.2 1309797 1311893 R hypothetical protein complement(1309797..1311893) Escherichia coli O157:H7 str. EDL933 959048 NP_286922.1 CDS ymcB NC_002655.2 1311893 1312639 R hypothetical protein complement(1311893..1312639) Escherichia coli O157:H7 str. EDL933 959049 NP_286923.1 CDS ymcC NC_002655.2 1312636 1313280 R regulator complement(1312636..1313280) Escherichia coli O157:H7 str. EDL933 959050 NP_286924.1 CDS ymcD NC_002655.2 1313387 1313710 R hypothetical protein complement(1313387..1313710) Escherichia coli O157:H7 str. EDL933 959051 NP_286925.1 CDS cspH NC_002655.2 1314134 1314346 R cold shock-like protein complement(1314134..1314346) Escherichia coli O157:H7 str. EDL933 959052 NP_286926.1 CDS cspG NC_002655.2 1314632 1314844 D cold shock protein CspG 1314632..1314844 Escherichia coli O157:H7 str. EDL933 959053 NP_286927.1 CDS sfa NC_002655.2 1315018 1315248 D cold shock gene 1315018..1315248 Escherichia coli O157:H7 str. EDL933 959054 NP_286928.1 CDS yccM NC_002655.2 1315459 1316532 R hypothetical protein complement(1315459..1316532) Escherichia coli O157:H7 str. EDL933 959055 NP_286929.2 CDS torS NC_002655.2 1316604 1319348 R Member of the two-component regulatory system torS/torR involved in the anaerobic utilization of trimethylamine-N-oxide; hybrid sensory histidine kinase TorS complement(1316604..1319348) Escherichia coli O157:H7 str. EDL933 959056 NP_286930.1 CDS torT NC_002655.2 1319431 1320459 D periplasmic sensory protein associated with the TorRS two-component regulatory system; TMAO reductase system periplasmic protein TorT 1319431..1320459 Escherichia coli O157:H7 str. EDL933 959057 NP_286931.1 CDS torR NC_002655.2 1320432 1321124 R response regulator in two-component regulatory system with TorS; involved in regulation of trimethylamine N-oxide reductase genes; DNA-binding transcriptional regulator TorR complement(1320432..1321124) Escherichia coli O157:H7 str. EDL933 959058 NP_286932.1 CDS torC NC_002655.2 1321254 1322426 D trimethylamine N-oxide reductase 1321254..1322426 Escherichia coli O157:H7 str. EDL933 959059 NP_286933.1 CDS torA NC_002655.2 1322426 1324972 D trimethylamine N-oxide reductase subunit 1322426..1324972 Escherichia coli O157:H7 str. EDL933 959060 NP_286934.1 CDS torD NC_002655.2 1324969 1325568 D TorD; involved in the biogenesis of torA; acts on torA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor; chaperone protein TorD 1324969..1325568 Escherichia coli O157:H7 str. EDL933 959061 NP_286935.1 CDS yccD NC_002655.2 1325722 1326027 R with CpbA modulates the activity of the dnaK chaperone system; interacts with CbpA and inhibits both the DnaJ-like co-chaperone activity and the DNA binding activity of CbpA; chaperone-modulator protein CbpM complement(1325722..1326027) Escherichia coli O157:H7 str. EDL933 959062 NP_286936.1 CDS cbpA NC_002655.2 1326027 1326947 R functional analog of DnaJ; co-chaperone with DnaK, molecular chaperone in an adaptive response to environmental stresses other than heat shock; curved DNA-binding protein CbpA complement(1326027..1326947) Escherichia coli O157:H7 str. EDL933 959063 NP_286937.1 CDS Z1419 NC_002655.2 1327207 1328106 D hypothetical protein 1327207..1328106 Escherichia coli O157:H7 str. EDL933 959064 NP_286938.1 CDS Z1420 NC_002655.2 1328114 1328464 D hypothetical protein 1328114..1328464 Escherichia coli O157:H7 str. EDL933 959065 NP_286939.1 CDS agp NC_002655.2 1328755 1329996 D glucose-1-phosphatase/inositol phosphatase 1328755..1329996 Escherichia coli O157:H7 str. EDL933 959066 NP_286940.1 CDS yccJ NC_002655.2 1330034 1330261 R hypothetical protein complement(1330034..1330261) Escherichia coli O157:H7 str. EDL933 959067 NP_286941.1 CDS wrbA NC_002655.2 1330282 1330827 R stationary phase that binds TrpR repressor; TrpR binding protein WrbA complement(1330282..1330827) Escherichia coli O157:H7 str. EDL933 959068 NP_286942.1 CDS intW NC_002655.2 1330857 1332191 R integrase for bacteriophage BP-933W complement(1330857..1332191) Escherichia coli O157:H7 str. EDL933 959069 NP_286943.1 CDS xisW NC_002655.2 1332220 1332519 R excisionase complement(1332220..1332519) Escherichia coli O157:H7 str. EDL933 959070 NP_286944.1 CDS Z1426 NC_002655.2 1332590 1332901 R hypothetical protein complement(1332590..1332901) Escherichia coli O157:H7 str. EDL933 959071 NP_286945.1 CDS Z1428 NC_002655.2 1332961 1333326 R No significant matches; hypothetical protein complement(1332961..1333326) Escherichia coli O157:H7 str. EDL933 959072 NP_286946.1 CDS Z1429 NC_002655.2 1333238 1333861 R hypothetical protein complement(1333238..1333861) Escherichia coli O157:H7 str. EDL933 959073 NP_286947.1 CDS Z1430 NC_002655.2 1333865 1334152 R hypothetical protein complement(1333865..1334152) Escherichia coli O157:H7 str. EDL933 959074 NP_286948.1 CDS Z1431 NC_002655.2 1334191 1334487 D No significant matches; hypothetical protein 1334191..1334487 Escherichia coli O157:H7 str. EDL933 959075 NP_286949.1 CDS Z1432 NC_002655.2 1334931 1335704 R hypothetical protein complement(1334931..1335704) Escherichia coli O157:H7 str. EDL933 959076 NP_286950.1 CDS Z1433 NC_002655.2 1336021 1336302 R hypothetical protein complement(1336021..1336302) Escherichia coli O157:H7 str. EDL933 959077 NP_286951.1 CDS Z1434 NC_002655.2 1336313 1336504 R hypothetical protein complement(1336313..1336504) Escherichia coli O157:H7 str. EDL933 959078 NP_286952.1 CDS exoW NC_002655.2 1336659 1337336 R exonuclease of bacteriophage BP-933W complement(1336659..1337336) Escherichia coli O157:H7 str. EDL933 959079 NP_286953.1 CDS betW NC_002655.2 1337333 1338118 R Bet recombination protein of bacteriophage BP-933W complement(1337333..1338118) Escherichia coli O157:H7 str. EDL933 959080 NP_286954.1 CDS gamW NC_002655.2 1338124 1338420 R host-nuclease inhibitor protein Gam of bacteriphage BP-933W complement(1338124..1338420) Escherichia coli O157:H7 str. EDL933 959081 NP_286955.1 CDS kilW NC_002655.2 1338496 1338765 R Kil protein of bacteriphage BP-933W complement(1338496..1338765) Escherichia coli O157:H7 str. EDL933 959082 NP_286956.1 CDS ssbW NC_002655.2 1338845 1339213 R single-stranded DNA binding protein complement(1338845..1339213) Escherichia coli O157:H7 str. EDL933 959083 NP_286957.1 CDS Z1441 NC_002655.2 1339364 1339834 R hypothetical protein complement(1339364..1339834) Escherichia coli O157:H7 str. EDL933 959084 NP_286958.1 CDS Z1442 NC_002655.2 1339893 1340276 R antitermination protein N of bacteriophage BP-933W complement(1339893..1340276) Escherichia coli O157:H7 str. EDL933 959085 NP_286959.1 CDS Z1443 NC_002655.2 1340765 1340929 R hypothetical protein complement(1340765..1340929) Escherichia coli O157:H7 str. EDL933 959086 NP_286960.1 CDS Z1444 NC_002655.2 1340932 1341978 R serine/threonine kinase encoded by bacteriophage BP-933W complement(1340932..1341978) Escherichia coli O157:H7 str. EDL933 959087 NP_286961.1 CDS Z1445 NC_002655.2 1341972 1342433 R hypothetical protein complement(1341972..1342433) Escherichia coli O157:H7 str. EDL933 959088 NP_286962.1 CDS Z1446 NC_002655.2 1342501 1342842 R hypothetical protein complement(1342501..1342842) Escherichia coli O157:H7 str. EDL933 959089 NP_286963.1 CDS Z1447 NC_002655.2 1342903 1343610 R repressor protein CI of bacteriophage BP-933W complement(1342903..1343610) Escherichia coli O157:H7 str. EDL933 959090 NP_286964.1 CDS Z1448 NC_002655.2 1343689 1343916 D regulatory protein Cro of bacteriophage BP-933W 1343689..1343916 Escherichia coli O157:H7 str. EDL933 959091 NP_286965.1 CDS Z1449 NC_002655.2 1344055 1344351 D regulatory protein CII of bacteriophage BP-933W 1344055..1344351 Escherichia coli O157:H7 str. EDL933 959092 NP_286966.1 CDS Z1450 NC_002655.2 1344384 1345322 D replication protein O of bacteriophage BP-933W 1344384..1345322 Escherichia coli O157:H7 str. EDL933 959093 NP_286967.1 CDS Z1451 NC_002655.2 1345319 1346020 D replication protein P of bacteriophage BP-933W 1345319..1346020 Escherichia coli O157:H7 str. EDL933 959094 NP_286968.1 CDS Z1452 NC_002655.2 1346378 1346656 D hypothetical protein 1346378..1346656 Escherichia coli O157:H7 str. EDL933 959095 NP_286969.1 CDS Z1453 NC_002655.2 1347208 1347654 D hypothetical protein 1347208..1347654 Escherichia coli O157:H7 str. EDL933 959096 NP_286970.1 CDS Z1454 NC_002655.2 1347651 1348178 D DNA N-6-adenine-methyltransferase of bacteriophage BP-933W 1347651..1348178 Escherichia coli O157:H7 str. EDL933 959097 NP_286971.1 CDS Z1456 NC_002655.2 1348366 1349409 D hypothetical protein 1348366..1349409 Escherichia coli O157:H7 str. EDL933 959098 NP_286972.1 CDS Z1457 NC_002655.2 1349555 1350283 D DNA-binding protein Roi of bacteriophage BP-933W 1349555..1350283 Escherichia coli O157:H7 str. EDL933 959099 NP_286973.1 CDS Z1458 NC_002655.2 1350283 1350888 D hypothetical protein 1350283..1350888 Escherichia coli O157:H7 str. EDL933 959100 NP_286974.1 CDS Z1459 NC_002655.2 1351072 1351506 D antitermination protein Q of bacteriophage BP-933W 1351072..1351506 Escherichia coli O157:H7 str. EDL933 959101 NP_286975.1 CDS Z1460 NC_002655.2 1351809 1351907 D hypothetical protein 1351809..1351907 Escherichia coli O157:H7 str. EDL933 959102 NP_286976.1 CDS stx2A NC_002655.2 1352290 1353249 D shiga-like toxin II A subunit encoded by bacteriophage BP-933W 1352290..1353249 Escherichia coli O157:H7 str. EDL933 959106 NP_286977.1 CDS stx2B NC_002655.2 1353261 1353530 D shiga-like toxin II B subunit encoded by bacteriophage BP-933W 1353261..1353530 Escherichia coli O157:H7 str. EDL933 959107 NP_286978.1 CDS Z1466 NC_002655.2 1354017 1355954 D hypothetical protein 1354017..1355954 Escherichia coli O157:H7 str. EDL933 959108 NP_286979.1 CDS Z1467 NC_002655.2 1356135 1356581 D hypothetical protein 1356135..1356581 Escherichia coli O157:H7 str. EDL933 959109 NP_286980.1 CDS Z1468 NC_002655.2 1356658 1356873 D lysis protein S of bacteriophage BP-933W 1356658..1356873 Escherichia coli O157:H7 str. EDL933 959110 NP_286981.1 CDS Z1469 NC_002655.2 1356878 1357411 D lysozyme protein R of bacteriophage BP-933W 1356878..1357411 Escherichia coli O157:H7 str. EDL933 959111 NP_286982.1 CDS Z1471 NC_002655.2 1357682 1358251 D No significant matches; antirepressor protein Ant of bacteriophage BP-933W 1357682..1358251 Escherichia coli O157:H7 str. EDL933 959112 NP_286983.1 CDS Z1473 NC_002655.2 1358405 1358869 D endopeptidase Rz of bacteriophage BP-933W 1358405..1358869 Escherichia coli O157:H7 str. EDL933 959113 NP_286984.1 CDS borW NC_002655.2 1358901 1359194 R Bor protein of bacteriophage BP-933W complement(1358901..1359194) Escherichia coli O157:H7 str. EDL933 959114 NP_286985.1 CDS Z1475 NC_002655.2 1359603 1360409 D terminase small subunit of bacteriophage BP-933W 1359603..1360409 Escherichia coli O157:H7 str. EDL933 959115 NP_286986.1 CDS Z1476 NC_002655.2 1360390 1362096 D terminase large subunit of bacteriophage BP-933W 1360390..1362096 Escherichia coli O157:H7 str. EDL933 959116 NP_286987.1 CDS Z1477 NC_002655.2 1362096 1364240 D portal protein of bacteriophage BP-933W 1362096..1364240 Escherichia coli O157:H7 str. EDL933 959117 NP_286988.1 CDS Z1478 NC_002655.2 1364398 1365405 D hypothetical protein 1364398..1365405 Escherichia coli O157:H7 str. EDL933 959118 NP_286989.1 CDS Z1479 NC_002655.2 1365429 1366643 D hypothetical protein 1365429..1366643 Escherichia coli O157:H7 str. EDL933 959119 NP_286990.1 CDS Z1480 NC_002655.2 1366699 1367088 D hypothetical protein 1366699..1367088 Escherichia coli O157:H7 str. EDL933 959120 NP_286991.1 CDS Z1481 NC_002655.2 1367138 1367599 D hypothetical protein 1367138..1367599 Escherichia coli O157:H7 str. EDL933 959121 NP_286992.1 CDS Z1482 NC_002655.2 1368146 1368796 D hypothetical protein 1368146..1368796 Escherichia coli O157:H7 str. EDL933 959122 NP_286993.1 CDS Z1483 NC_002655.2 1368793 1370730 D tail fiber protein of bacteriophage BP-933W 1368793..1370730 Escherichia coli O157:H7 str. EDL933 959123 NP_286994.1 CDS Z1484 NC_002655.2 1370693 1371001 D tail fiber protein of bacteriophage BP-933W 1370693..1371001 Escherichia coli O157:H7 str. EDL933 959124 NP_286995.1 CDS Z1485 NC_002655.2 1371048 1371329 D hypothetical protein 1371048..1371329 Escherichia coli O157:H7 str. EDL933 959125 NP_286996.1 CDS Z1486 NC_002655.2 1371546 1373249 D hypothetical protein 1371546..1373249 Escherichia coli O157:H7 str. EDL933 959126 NP_286997.1 CDS Z1487 NC_002655.2 1373291 1374514 D hypothetical protein 1373291..1374514 Escherichia coli O157:H7 str. EDL933 959127 NP_286998.1 CDS Z1488 NC_002655.2 1374813 1375430 D hypothetical protein 1374813..1375430 Escherichia coli O157:H7 str. EDL933 959128 NP_286999.1 CDS lomW NC_002655.2 1375521 1376255 D outer membrane protein Lom of bacteriophage BP-933W 1375521..1376255 Escherichia coli O157:H7 str. EDL933 959129 NP_287000.1 CDS Z1490 NC_002655.2 1376685 1377086 D hypothetical protein 1376685..1377086 Escherichia coli O157:H7 str. EDL933 959130 NP_287001.1 CDS Z1491 NC_002655.2 1377180 1377836 D hypothetical protein 1377180..1377836 Escherichia coli O157:H7 str. EDL933 959131 NP_287002.1 CDS Z1492 NC_002655.2 1377839 1378285 D hypothetical protein 1377839..1378285 Escherichia coli O157:H7 str. EDL933 959132 NP_287003.1 CDS Z1493 NC_002655.2 1378295 1378546 D hypothetical protein 1378295..1378546 Escherichia coli O157:H7 str. EDL933 959133 NP_287004.1 CDS Z1494 NC_002655.2 1378557 1379822 D hypothetical protein 1378557..1379822 Escherichia coli O157:H7 str. EDL933 959134 NP_287005.1 CDS Z1495 NC_002655.2 1379853 1388273 D hypothetical protein 1379853..1388273 Escherichia coli O157:H7 str. EDL933 959135 NP_287006.1 CDS Z1498 NC_002655.2 1388824 1389168 R hypothetical protein complement(1388824..1389168) Escherichia coli O157:H7 str. EDL933 959136 NP_287007.1 CDS Z1500 NC_002655.2 1389734 1390129 R hypothetical protein complement(1389734..1390129) Escherichia coli O157:H7 str. EDL933 959137 NP_287008.1 CDS Z1501 NC_002655.2 1390129 1391028 R hypothetical protein complement(1390129..1391028) Escherichia coli O157:H7 str. EDL933 959139 NP_287009.1 CDS Z1503 NC_002655.2 1391294 1391923 R hypothetical protein complement(1391294..1391923) Escherichia coli O157:H7 str. EDL933 959140 NP_287011.1 CDS ycdG NC_002655.2 1393103 1394497 R transporter complement(1393103..1394497) Escherichia coli O157:H7 str. EDL933 959142 NP_287012.1 CDS Z1506 NC_002655.2 1394452 1394910 R 4-hydroxyphenylacetate 3-monooxygenase complement(1394452..1394910) Escherichia coli O157:H7 str. EDL933 959143 NP_287013.1 CDS Z1507 NC_002655.2 1394957 1395547 R hypothetical protein complement(1394957..1395547) Escherichia coli O157:H7 str. EDL933 959144 NP_287014.1 CDS Z1508 NC_002655.2 1395557 1396357 R acetyltransferase complement(1395557..1396357) Escherichia coli O157:H7 str. EDL933 959145 NP_287015.1 CDS Z1509 NC_002655.2 1396365 1396751 R hypothetical protein complement(1396365..1396751) Escherichia coli O157:H7 str. EDL933 959146 NP_287016.1 CDS Z1510 NC_002655.2 1396763 1397497 R synthetase complement(1396763..1397497) Escherichia coli O157:H7 str. EDL933 959147 NP_287017.1 CDS Z1511 NC_002655.2 1397455 1398603 R hypothetical protein complement(1397455..1398603) Escherichia coli O157:H7 str. EDL933 959148 NP_287018.1 CDS ycdC NC_002655.2 1398834 1399472 D tet operon regulator 1398834..1399472 Escherichia coli O157:H7 str. EDL933 959149 NP_287019.1 CDS putA NC_002655.2 1399512 1403474 R proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichai coli this protein also self-regulates transcription via a DNA-binding domain at the N-terminus; forms dimers and is a peripherally membrane-associated protein; trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase complement(1399512..1403474) Escherichia coli O157:H7 str. EDL933 959150 NP_287020.1 CDS putP NC_002655.2 1403897 1405405 D major sodium/proline symporter 1403897..1405405 Escherichia coli O157:H7 str. EDL933 959151 NP_287021.1 CDS Z1516 NC_002655.2 1405554 1406897 R No significant matches; hypothetical protein complement(1405554..1406897) Escherichia coli O157:H7 str. EDL933 959152 NP_287022.1 CDS Z1517 NC_002655.2 1407460 1407606 D No significant matches; hypothetical protein 1407460..1407606 Escherichia coli O157:H7 str. EDL933 959153 NP_287023.1 CDS Z1518 NC_002655.2 1407897 1408043 R No significant matches; hypothetical protein complement(1407897..1408043) Escherichia coli O157:H7 str. EDL933 959154 NP_287024.1 CDS Z1519 NC_002655.2 1408070 1408909 D hypothetical protein 1408070..1408909 Escherichia coli O157:H7 str. EDL933 959155 NP_287025.1 CDS ycdO NC_002655.2 1408967 1410094 D hypothetical protein 1408967..1410094 Escherichia coli O157:H7 str. EDL933 959156 NP_287026.1 CDS ycdB NC_002655.2 1410100 1411371 D hypothetical protein 1410100..1411371 Escherichia coli O157:H7 str. EDL933 959157 NP_287027.1 CDS phoH NC_002655.2 1411715 1412779 D hypothetical protein 1411715..1412779 Escherichia coli O157:H7 str. EDL933 959158 NP_287028.1 CDS pgaD NC_002655.2 1412829 1413242 R in Yersinia this gene is involved in biofilm formation and hemin adsorption; in Escherichia coli it is involved in PGA biosynthesis and export; PGA biosynthesis protein complement(1412829..1413242) Escherichia coli O157:H7 str. EDL933 959159 NP_287029.1 CDS ycdQ NC_002655.2 1413244 1414569 R predicted polysaccharide polymerase involved in biofilm formation; required for the synthesis of the beta-1,6-N-acetylglucosamine polysaccharide; PgaC; in Yersinia the HmsR protein is an inner membrane protein; N-glycosyltransferase complement(1413244..1414569) Escherichia coli O157:H7 str. EDL933 959160 NP_287030.1 CDS pgaB NC_002655.2 1414562 1416580 R in Yersinia this protein is involved in biofilm formation and hemin adsorption; related protein PgaB in Escherichia coli is an outer membrane N-deacetylase involved in poly-beta-1,6-N-acetyl-D-glucosamine (PGA) export; outer membrane N-deacetylase complement(1414562..1416580) Escherichia coli O157:H7 str. EDL933 959161 NP_287031.1 CDS pgaA NC_002655.2 1416589 1419012 R outer membrane protein essential for the synthesis of poly-beta-1,6-N-acetyl-D-glucosamine (PGA); adhesin required for biofilm formation; PgaA (HmsH) seems to translocate and/or dock PGA to the cell surface; member of the hmsHFRS (ycdSRQP or pgaABCD in Escherichia coli) operon in Yersinia; outer membrane protein PgaA complement(1416589..1419012) Escherichia coli O157:H7 str. EDL933 959162 NP_287032.1 CDS ycdT NC_002655.2 1419599 1420957 D hypothetical protein 1419599..1420957 Escherichia coli O157:H7 str. EDL933 959163 NP_287033.1 CDS Z1528 NC_002655.2 1421055 1422665 D hypothetical protein 1421055..1422665 Escherichia coli O157:H7 str. EDL933 959164 NP_287034.1 CDS Z1530 NC_002655.2 1422767 1423258 R hypothetical protein complement(1422767..1423258) Escherichia coli O157:H7 str. EDL933 959165 NP_287035.1 CDS Z1531 NC_002655.2 1423263 1424075 R hypothetical protein complement(1423263..1424075) Escherichia coli O157:H7 str. EDL933 959166 NP_287036.1 CDS Z1532 NC_002655.2 1424667 1424747 D No significant matches; hypothetical protein 1424667..1424747 Escherichia coli O157:H7 str. EDL933 959167 NP_287037.1 CDS Z1533 NC_002655.2 1424754 1425545 D oxidoreductase 1424754..1425545 Escherichia coli O157:H7 str. EDL933 959168 NP_287038.1 CDS Z1534 NC_002655.2 1425691 1426380 R chaperone complement(1425691..1426380) Escherichia coli O157:H7 str. EDL933 959169 NP_287039.1 CDS Z1535 NC_002655.2 1426377 1427711 R hypothetical protein complement(1426377..1427711) Escherichia coli O157:H7 str. EDL933 959170 NP_287040.1 CDS Z1536 NC_002655.2 1427727 1430249 R usher protein complement(1427727..1430249) Escherichia coli O157:H7 str. EDL933 959171 NP_287041.1 CDS Z1537 NC_002655.2 1430302 1431024 R chaperone complement(1430302..1431024) Escherichia coli O157:H7 str. EDL933 959172 NP_287042.1 CDS Z1538 NC_002655.2 1431089 1431649 R pilin subunit complement(1431089..1431649) Escherichia coli O157:H7 str. EDL933 959173 NP_287043.1 CDS Z1539 NC_002655.2 1431692 1432315 R No significant matches; hypothetical protein complement(1431692..1432315) Escherichia coli O157:H7 str. EDL933 959174 NP_287044.1 CDS Z1540 NC_002655.2 1432584 1432694 R No significant matches; hypothetical protein complement(1432584..1432694) Escherichia coli O157:H7 str. EDL933 959175 NP_287045.1 CDS Z1541 NC_002655.2 1433156 1433275 R No significant matches; hypothetical protein complement(1433156..1433275) Escherichia coli O157:H7 str. EDL933 959176 NP_287046.1 CDS Z1542 NC_002655.2 1433706 1437518 D ShlA/HecA/FhaA exofamily protein 1433706..1437518 Escherichia coli O157:H7 str. EDL933 959177 NP_287047.1 CDS Z1543 NC_002655.2 1437607 1439226 D ShlA/HecA/FhaA exofamily protein 1437607..1439226 Escherichia coli O157:H7 str. EDL933 959178 NP_287048.1 CDS Z1544 NC_002655.2 1439242 1439610 D ACP synthase 1439242..1439610 Escherichia coli O157:H7 str. EDL933 959179 NP_287049.1 CDS Z1545 NC_002655.2 1439630 1440385 D fatty acyl chain reductase 1439630..1440385 Escherichia coli O157:H7 str. EDL933 959180 NP_287050.1 CDS Z1546 NC_002655.2 1440389 1440937 D fatty acyl chain dehydrase 1440389..1440937 Escherichia coli O157:H7 str. EDL933 959181 NP_287051.1 CDS Z1547 NC_002655.2 1440959 1441240 D acyl carrier protein 1440959..1441240 Escherichia coli O157:H7 str. EDL933 959182 NP_287052.1 CDS Z1548 NC_002655.2 1441276 1442436 D glycine cleavage system protein T 1441276..1442436 Escherichia coli O157:H7 str. EDL933 959183 NP_287053.1 CDS Z1549 NC_002655.2 1442510 1445068 D beta-ketoacyl-[acyl carrier protein] synthase 1442510..1445068 Escherichia coli O157:H7 str. EDL933 959185 NP_287054.1 CDS Z1550 NC_002655.2 1445073 1446296 D hypothetical protein 1445073..1446296 Escherichia coli O157:H7 str. EDL933 959186 NP_287055.1 CDS Z1551 NC_002655.2 1446293 1447246 D No significant matches; hypothetical protein 1446293..1447246 Escherichia coli O157:H7 str. EDL933 959187 NP_287056.1 CDS Z1552 NC_002655.2 1447257 1447964 D hypothetical protein 1447257..1447964 Escherichia coli O157:H7 str. EDL933 959188 NP_287057.1 CDS Z1553 NC_002655.2 1447948 1448604 D No significant matches; hypothetical protein 1447948..1448604 Escherichia coli O157:H7 str. EDL933 959189 NP_287058.1 CDS Z1554 NC_002655.2 1448605 1449915 D hypothetical protein 1448605..1449915 Escherichia coli O157:H7 str. EDL933 959190 NP_287059.1 CDS Z1555 NC_002655.2 1449924 1450712 D No significant matches; hypothetical protein 1449924..1450712 Escherichia coli O157:H7 str. EDL933 959191 NP_287060.1 CDS Z1556 NC_002655.2 1450709 1452097 D No significant matches; hypothetical protein 1450709..1452097 Escherichia coli O157:H7 str. EDL933 959192 NP_287061.1 CDS Z1557 NC_002655.2 1452729 1453052 D hypothetical protein 1452729..1453052 Escherichia coli O157:H7 str. EDL933 959193 NP_287062.1 CDS ycdU NC_002655.2 1453049 1454035 D hypothetical protein 1453049..1454035 Escherichia coli O157:H7 str. EDL933 959194 NP_287063.1 CDS Z1559 NC_002655.2 1454402 1455604 D P4 family integrase 1454402..1455604 Escherichia coli O157:H7 str. EDL933 959195 NP_287064.1 CDS Z1560 NC_002655.2 1455791 1457608 R No significant matches; hypothetical protein complement(1455791..1457608) Escherichia coli O157:H7 str. EDL933 959196 NP_287065.1 CDS Z1561 NC_002655.2 1457976 1458077 D hypothetical protein 1457976..1458077 Escherichia coli O157:H7 str. EDL933 959197 NP_287066.1 CDS Z1562 NC_002655.2 1458104 1458541 D hypothetical protein 1458104..1458541 Escherichia coli O157:H7 str. EDL933 959198 NP_287067.1 CDS Z1563 NC_002655.2 1458720 1459016 D prophage regulatory protein 1458720..1459016 Escherichia coli O157:H7 str. EDL933 959199 NP_287068.1 CDS Z1564 NC_002655.2 1459243 1459440 D hypothetical protein 1459243..1459440 Escherichia coli O157:H7 str. EDL933 959200 NP_287069.1 CDS Z1565 NC_002655.2 1459641 1461044 D hypothetical protein 1459641..1461044 Escherichia coli O157:H7 str. EDL933 959201 NP_287071.1 CDS Z1567 NC_002655.2 1461865 1462428 D No significant matches; hypothetical protein 1461865..1462428 Escherichia coli O157:H7 str. EDL933 959205 NP_287072.1 CDS Z1568 NC_002655.2 1462559 1464943 D helicase 1462559..1464943 Escherichia coli O157:H7 str. EDL933 959206 NP_287073.1 CDS Z1569 NC_002655.2 1465105 1465374 R No significant matches; hypothetical protein complement(1465105..1465374) Escherichia coli O157:H7 str. EDL933 959208 NP_287074.1 CDS Z1570 NC_002655.2 1465700 1467238 R hypothetical protein complement(1465700..1467238) Escherichia coli O157:H7 str. EDL933 959209 NP_287075.1 CDS Z1571 NC_002655.2 1467288 1467635 R hypothetical protein complement(1467288..1467635) Escherichia coli O157:H7 str. EDL933 959210 NP_287076.1 CDS Z1572 NC_002655.2 1468088 1468399 R transposase complement(1468088..1468399) Escherichia coli O157:H7 str. EDL933 959212 NP_287077.1 CDS Z1573 NC_002655.2 1468539 1469357 D hypothetical protein 1468539..1469357 Escherichia coli O157:H7 str. EDL933 959213 NP_287078.1 CDS Z1574 NC_002655.2 1469470 1470009 D complement resistance protein 1469470..1470009 Escherichia coli O157:H7 str. EDL933 959217 NP_287079.1 CDS Z1575 NC_002655.2 1470057 1470350 R No significant matches; hypothetical protein complement(1470057..1470350) Escherichia coli O157:H7 str. EDL933 959219 NP_287080.1 CDS Z1576 NC_002655.2 1470332 1470622 R No significant matches; hypothetical protein complement(1470332..1470622) Escherichia coli O157:H7 str. EDL933 959222 NP_287082.1 CDS Z1578 NC_002655.2 1471308 1471667 D diacylglycerol kinase 1471308..1471667 Escherichia coli O157:H7 str. EDL933 959224 NP_287083.1 CDS Z1579 NC_002655.2 1471760 1473379 R hypothetical protein complement(1471760..1473379) Escherichia coli O157:H7 str. EDL933 959225 NP_287084.1 CDS Z1580 NC_002655.2 1473604 1473885 R No significant matches; hypothetical protein complement(1473604..1473885) Escherichia coli O157:H7 str. EDL933 959226 NP_287085.1 CDS ureD_2 NC_002655.2 1474260 1474958 D urease accessory protein D 1474260..1474958 Escherichia coli O157:H7 str. EDL933 959228 NP_287086.1 CDS ureA NC_002655.2 1475049 1475351 D UreA, with UreB and UreC catalyzes the hydrolysis of urea into ammonia and carbon dioxide; nickel metalloenzyme; accessory proteins UreD, UreE, UreF, and UreG are necessary for assembly of the metallocenter; urease subunit gamma 1475049..1475351 Escherichia coli O157:H7 str. EDL933 959229 NP_287087.1 CDS ureB NC_002655.2 1475360 1475680 D ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori and Yersinia enterocolitica the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 UreC (alpha) and 3 UreAB (gamma/beta); in Brucella suis the urease encoded by this operon (one of two urease-encoding operons found in its genome) is involved with urease activity, optimum growth, resistance to low-pH killing in-vitro and persistence in-vivo, while the other operon does not seem to be active; urease subunit beta 1475360..1475680 Escherichia coli O157:H7 str. EDL933 959230 NP_287088.1 CDS ureC NC_002655.2 1475670 1477376 D ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits; urease subunit alpha 1475670..1477376 Escherichia coli O157:H7 str. EDL933 959231 NP_287089.1 CDS ureE NC_002655.2 1477386 1477850 D involved in the assembly of the urease metallocenter; possible nickel donor; urease accessory protein UreE 1477386..1477850 Escherichia coli O157:H7 str. EDL933 959232 NP_287090.1 CDS ureF_2 NC_002655.2 1477851 1478525 D urease accessory protein F 1477851..1478525 Escherichia coli O157:H7 str. EDL933 959233 NP_287091.1 CDS ureG_2 NC_002655.2 1478537 1479154 D urease accessory protein G 1478537..1479154 Escherichia coli O157:H7 str. EDL933 959235 NP_287092.1 CDS Z1588 NC_002655.2 1479202 1479333 R hypothetical protein complement(1479202..1479333) Escherichia coli O157:H7 str. EDL933 959236 NP_287093.1 CDS Z1589 NC_002655.2 1479410 1479751 R hypothetical protein complement(1479410..1479751) Escherichia coli O157:H7 str. EDL933 959237 NP_287094.1 CDS Z1590 NC_002655.2 1479813 1479941 R hypothetical protein complement(1479813..1479941) Escherichia coli O157:H7 str. EDL933 959240 NP_287095.1 CDS rpmE2 NC_002655.2 1480366 1480629 D RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 1480366..1480629 Escherichia coli O157:H7 str. EDL933 959241 NP_287096.1 CDS Z1592 NC_002655.2 1480931 1481071 D No significant matches; hypothetical protein 1480931..1481071 Escherichia coli O157:H7 str. EDL933 959242 NP_287097.1 CDS Z1593 NC_002655.2 1481486 1481638 R No significant matches; hypothetical protein complement(1481486..1481638) Escherichia coli O157:H7 str. EDL933 959244 NP_287098.1 CDS Z1594 NC_002655.2 1481944 1482681 R No significant matches; hypothetical protein complement(1481944..1482681) Escherichia coli O157:H7 str. EDL933 959245 NP_287099.1 CDS Z1595 NC_002655.2 1483064 1483204 R No significant matches; hypothetical protein complement(1483064..1483204) Escherichia coli O157:H7 str. EDL933 959249 NP_287100.1 CDS Z1596 NC_002655.2 1483635 1483808 R No significant matches; hypothetical protein complement(1483635..1483808) Escherichia coli O157:H7 str. EDL933 959253 NP_287101.1 CDS Z1597 NC_002655.2 1484148 1484633 R hypothetical protein complement(1484148..1484633) Escherichia coli O157:H7 str. EDL933 959255 NP_287102.1 CDS Z1598 NC_002655.2 1484953 1485378 D hypothetical protein 1484953..1485378 Escherichia coli O157:H7 str. EDL933 959256 NP_287103.1 CDS Z1599 NC_002655.2 1485375 1485725 D hypothetical protein 1485375..1485725 Escherichia coli O157:H7 str. EDL933 959259 NP_287104.1 CDS Z1600 NC_002655.2 1485756 1487369 D hypothetical protein 1485756..1487369 Escherichia coli O157:H7 str. EDL933 959261 NP_287105.1 CDS Z1601 NC_002655.2 1487373 1488230 R hypothetical protein complement(1487373..1488230) Escherichia coli O157:H7 str. EDL933 959262 NP_287106.1 CDS Z1602 NC_002655.2 1488312 1488674 R hypothetical protein complement(1488312..1488674) Escherichia coli O157:H7 str. EDL933 959265 NP_287107.1 CDS terW_2 NC_002655.2 1489230 1489697 R hypothetical protein complement(1489230..1489697) Escherichia coli O157:H7 str. EDL933 959266 NP_287108.1 CDS Z1604 NC_002655.2 1489715 1490923 R No significant matches; hypothetical protein complement(1489715..1490923) Escherichia coli O157:H7 str. EDL933 959267 NP_287109.1 CDS Z1605 NC_002655.2 1490934 1491890 R hypothetical protein complement(1490934..1491890) Escherichia coli O157:H7 str. EDL933 959268 NP_287110.1 CDS Z1606 NC_002655.2 1491890 1493005 R hypothetical protein complement(1491890..1493005) Escherichia coli O157:H7 str. EDL933 959269 NP_287111.1 CDS Z1607 NC_002655.2 1492971 1493966 R hypothetical protein complement(1492971..1493966) Escherichia coli O157:H7 str. EDL933 959270 NP_287112.1 CDS Z1608 NC_002655.2 1493737 1494879 R hypothetical protein complement(1493737..1494879) Escherichia coli O157:H7 str. EDL933 959271 NP_287113.1 CDS Z1609 NC_002655.2 1494889 1495947 R hypothetical protein complement(1494889..1495947) Escherichia coli O157:H7 str. EDL933 959272 NP_287114.1 CDS terZ_2 NC_002655.2 1496270 1496851 D phage inhibition, colicin resistance and tellurite resistance protein 1496270..1496851 Escherichia coli O157:H7 str. EDL933 959274 NP_287115.1 CDS terA_2 NC_002655.2 1496851 1498008 D phage inhibition, colicin resistance and tellurite resistance protein 1496851..1498008 Escherichia coli O157:H7 str. EDL933 959276 NP_287116.1 CDS terB_2 NC_002655.2 1498031 1498486 D phage inhibition, colicin resistance and tellurite resistance protein 1498031..1498486 Escherichia coli O157:H7 str. EDL933 959277 NP_287117.1 CDS terC_2 NC_002655.2 1498509 1499549 D phage inhibition, colicin resistance and tellurite resistance protein 1498509..1499549 Escherichia coli O157:H7 str. EDL933 959278 NP_287118.1 CDS terD_2 NC_002655.2 1499598 1500176 D phage inhibition, colicin resistance and tellurite resistance protein 1499598..1500176 Escherichia coli O157:H7 str. EDL933 959279 NP_287119.1 CDS terE_2 NC_002655.2 1500245 1500820 D phage inhibition, colicin resistance and tellurite resistance protein 1500245..1500820 Escherichia coli O157:H7 str. EDL933 959280 NP_287120.1 CDS terF_2 NC_002655.2 1501242 1501550 D phage inhibition, colicin resistance and tellurite resistance protein 1501242..1501550 Escherichia coli O157:H7 str. EDL933 959282 NP_287121.1 CDS Z1617 NC_002655.2 1502142 1504232 R IrgA-homologue adhesin (Iha); TonB-dependent; acts as a specific receptor of enterobactin; fur-regulated; urovirulence factor; bifunctional enterobactin receptor/adhesin protein complement(1502142..1504232) Escherichia coli O157:H7 str. EDL933 959284 NP_287123.1 CDS Z1619 NC_002655.2 1504902 1505189 R No significant matches; hypothetical protein complement(1504902..1505189) Escherichia coli O157:H7 str. EDL933 959287 NP_287124.1 CDS Z1620 NC_002655.2 1505686 1505904 D hypothetical protein 1505686..1505904 Escherichia coli O157:H7 str. EDL933 959288 NP_287125.1 CDS Z1621 NC_002655.2 1506306 1506404 R No significant matches; hypothetical protein complement(1506306..1506404) Escherichia coli O157:H7 str. EDL933 959290 NP_287126.1 CDS Z1622 NC_002655.2 1506537 1506872 D hypothetical protein 1506537..1506872 Escherichia coli O157:H7 str. EDL933 959291 NP_287127.1 CDS Z1623 NC_002655.2 1507389 1507523 D No significant matches; hypothetical protein 1507389..1507523 Escherichia coli O157:H7 str. EDL933 959292 NP_287128.1 CDS Z1624 NC_002655.2 1507653 1507847 R No significant matches; hypothetical protein complement(1507653..1507847) Escherichia coli O157:H7 str. EDL933 959297 NP_287129.1 CDS Z1625 NC_002655.2 1508168 1508440 D No significant matches; hypothetical protein 1508168..1508440 Escherichia coli O157:H7 str. EDL933 959299 NP_287130.1 CDS Z1626 NC_002655.2 1508832 1508939 D No significant matches; hypothetical protein 1508832..1508939 Escherichia coli O157:H7 str. EDL933 959300 NP_287131.1 CDS Z1627 NC_002655.2 1509005 1509202 D No significant matches; hypothetical protein 1509005..1509202 Escherichia coli O157:H7 str. EDL933 959302 NP_287132.1 CDS Z1628 NC_002655.2 1509286 1509405 D No significant matches; hypothetical protein 1509286..1509405 Escherichia coli O157:H7 str. EDL933 959303 NP_287133.1 CDS Z1629m NC_002655.2 1509932 1511055 D glycosyl transferase join(1509932..1510384,1510384..1511055) Escherichia coli O157:H7 str. EDL933 959648 NP_287134.1 CDS Z1631 NC_002655.2 1511197 1511472 R hypothetical protein complement(1511197..1511472) Escherichia coli O157:H7 str. EDL933 959304 NP_287135.1 CDS Z1632 NC_002655.2 1511474 1511977 R IS1 protein InsB complement(1511474..1511977) Escherichia coli O157:H7 str. EDL933 959307 NP_287136.1 CDS Z1633 NC_002655.2 1512409 1512879 R No significant matches; hypothetical protein complement(1512409..1512879) Escherichia coli O157:H7 str. EDL933 959308 NP_287137.1 CDS Z1634 NC_002655.2 1513325 1513834 D No significant matches; hypothetical protein 1513325..1513834 Escherichia coli O157:H7 str. EDL933 959310 NP_287138.1 CDS Z1635 NC_002655.2 1513923 1514546 D No significant matches; hypothetical protein 1513923..1514546 Escherichia coli O157:H7 str. EDL933 959311 NP_287139.1 CDS Z1636 NC_002655.2 1514642 1514875 D No significant matches; hypothetical protein 1514642..1514875 Escherichia coli O157:H7 str. EDL933 959314 NP_287140.1 CDS Z1637 NC_002655.2 1514928 1515119 R No significant matches; hypothetical protein complement(1514928..1515119) Escherichia coli O157:H7 str. EDL933 959315 NP_287141.1 CDS Z1638 NC_002655.2 1515713 1516600 R transposase complement(1515713..1516600) Escherichia coli O157:H7 str. EDL933 959316 NP_287142.1 CDS Z1639 NC_002655.2 1516600 1516926 R hypothetical protein complement(1516600..1516926) Escherichia coli O157:H7 str. EDL933 959319 NP_287143.1 CDS Z1640 NC_002655.2 1517107 1518153 D hypothetical protein 1517107..1518153 Escherichia coli O157:H7 str. EDL933 959321 NP_287144.1 CDS Z1641 NC_002655.2 1518394 1518909 D No significant matches; hypothetical protein 1518394..1518909 Escherichia coli O157:H7 str. EDL933 959322 NP_287145.1 CDS Z1642 NC_002655.2 1518939 1521074 D hypothetical protein 1518939..1521074 Escherichia coli O157:H7 str. EDL933 959324 NP_287146.1 CDS Z1643 NC_002655.2 1521574 1522806 D hypothetical protein 1521574..1522806 Escherichia coli O157:H7 str. EDL933 959328 NP_287147.1 CDS Z1644 NC_002655.2 1522791 1523429 D hypothetical protein 1522791..1523429 Escherichia coli O157:H7 str. EDL933 959329 NP_287148.1 CDS Z1645 NC_002655.2 1523798 1524442 D No significant matches; hypothetical protein 1523798..1524442 Escherichia coli O157:H7 str. EDL933 959330 NP_287149.1 CDS Z1646 NC_002655.2 1524490 1524645 D No significant matches; hypothetical protein 1524490..1524645 Escherichia coli O157:H7 str. EDL933 959331 NP_287150.1 CDS Z1647 NC_002655.2 1525140 1525388 R hypothetical protein complement(1525140..1525388) Escherichia coli O157:H7 str. EDL933 959333 NP_287151.1 CDS Z1648 NC_002655.2 1525442 1525867 D hypothetical protein 1525442..1525867 Escherichia coli O157:H7 str. EDL933 959334 NP_287152.1 CDS Z1649 NC_002655.2 1526167 1526349 R No significant matches; hypothetical protein complement(1526167..1526349) Escherichia coli O157:H7 str. EDL933 959335 NP_287153.1 CDS Z1650 NC_002655.2 1526678 1527550 D hypothetical protein 1526678..1527550 Escherichia coli O157:H7 str. EDL933 959336 NP_287154.1 CDS Z1651 NC_002655.2 1527754 1530771 D adhesin 1527754..1530771 Escherichia coli O157:H7 str. EDL933 959338 NP_287155.1 CDS Z1652 NC_002655.2 1530879 1533266 D hypothetical protein 1530879..1533266 Escherichia coli O157:H7 str. EDL933 959340 NP_287156.1 CDS Z1653 NC_002655.2 1533263 1534168 D hypothetical protein 1533263..1534168 Escherichia coli O157:H7 str. EDL933 959341 NP_287157.1 CDS Z1654 NC_002655.2 1534165 1535235 D hypothetical protein 1534165..1535235 Escherichia coli O157:H7 str. EDL933 959342 NP_287158.1 CDS Z1655 NC_002655.2 1535575 1536393 D hypothetical protein 1535575..1536393 Escherichia coli O157:H7 str. EDL933 959343 NP_287159.1 CDS Z1656 NC_002655.2 1536484 1536969 D hypothetical protein 1536484..1536969 Escherichia coli O157:H7 str. EDL933 959345 NP_287160.1 CDS Z1657 NC_002655.2 1536985 1537461 D RadC family DNA repair protein 1536985..1537461 Escherichia coli O157:H7 str. EDL933 959346 NP_287161.1 CDS Z1658 NC_002655.2 1537908 1538282 D structural protein 1537908..1538282 Escherichia coli O157:H7 str. EDL933 959347 NP_287162.1 CDS Z1660 NC_002655.2 1538585 1539472 R transposase for IS629 complement(1538585..1539472) Escherichia coli O157:H7 str. EDL933 959348 NP_287163.1 CDS Z1661 NC_002655.2 1539472 1539798 R hypothetical protein complement(1539472..1539798) Escherichia coli O157:H7 str. EDL933 959350 NP_287164.1 CDS Z1662 NC_002655.2 1540013 1540504 D hypothetical protein 1540013..1540504 Escherichia coli O157:H7 str. EDL933 959353 NP_287165.1 CDS Z1663 NC_002655.2 1540471 1540713 D hypothetical protein 1540471..1540713 Escherichia coli O157:H7 str. EDL933 959354 NP_287166.1 CDS Z1664 NC_002655.2 1540798 1541640 D hypothetical protein 1540798..1541640 Escherichia coli O157:H7 str. EDL933 959356 NP_287167.1 CDS ycdW NC_002655.2 1542072 1543049 D dehydrogenase 1542072..1543049 Escherichia coli O157:H7 str. EDL933 959358 NP_287168.1 CDS ycdX NC_002655.2 1543104 1543841 D hydrolase 1543104..1543841 Escherichia coli O157:H7 str. EDL933 959359 NP_287169.1 CDS ycdY NC_002655.2 1543865 1544419 D oxidoreductase component 1543865..1544419 Escherichia coli O157:H7 str. EDL933 959360 NP_287170.1 CDS ycdZ NC_002655.2 1544473 1545012 D hypothetical protein 1544473..1545012 Escherichia coli O157:H7 str. EDL933 959362 NP_287171.1 CDS csgG NC_002655.2 1545076 1545909 R curli production assembly/transport component, 2nd curli operon complement(1545076..1545909) Escherichia coli O157:H7 str. EDL933 959365 NP_287172.1 CDS csgF NC_002655.2 1545936 1546352 R nucleator protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex; curli assembly protein CsgF complement(1545936..1546352) Escherichia coli O157:H7 str. EDL933 959366 NP_287173.1 CDS csgE NC_002655.2 1546377 1546766 R chaperone-like protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex; curli assembly protein CsgE complement(1546377..1546766) Escherichia coli O157:H7 str. EDL933 959367 NP_287174.1 CDS csgD NC_002655.2 1546771 1547421 R activates the csgBA and csgDEFG operons involved in biofilm formation; DNA-binding transcriptional regulator CsgD complement(1546771..1547421) Escherichia coli O157:H7 str. EDL933 959369 NP_287175.1 CDS csgB NC_002655.2 1548176 1548631 D CsgB; functions as a nucleator in the assembly of curli (coiled surface structures) on the cell surface; curlin minor subunit 1548176..1548631 Escherichia coli O157:H7 str. EDL933 959370 NP_287176.1 CDS csgA NC_002655.2 1548672 1549130 D cryptic curlin major subunit 1548672..1549130 Escherichia coli O157:H7 str. EDL933 959371 NP_287177.1 CDS csgC NC_002655.2 1549189 1549521 D involved in autoagglutination of curliated cells; not involved in production of curli fibers; autoagglutination protein 1549189..1549521 Escherichia coli O157:H7 str. EDL933 959373 NP_287178.1 CDS Z1678 NC_002655.2 1549642 1549953 D hypothetical protein 1549642..1549953 Escherichia coli O157:H7 str. EDL933 959374 NP_287179.1 CDS Z1679 NC_002655.2 1550048 1550581 D hypothetical protein 1550048..1550581 Escherichia coli O157:H7 str. EDL933 959375 NP_287180.1 CDS ymdC NC_002655.2 1550523 1552004 D synthase 1550523..1552004 Escherichia coli O157:H7 str. EDL933 959376 NP_287181.1 CDS mdoC NC_002655.2 1552012 1553169 R required for the transfer of succinyl residues to the glucan backbone; glucans biosynthesis protein complement(1552012..1553169) Escherichia coli O157:H7 str. EDL933 959379 NP_287182.1 CDS mdoG NC_002655.2 1553562 1555097 D involved in the biosynthesis of osmoregulated periplasmic glucans; required for the assembly of the polyglucose structure of glucan; glucan biosynthesis protein G 1553562..1555097 Escherichia coli O157:H7 str. EDL933 959380 NP_287183.1 CDS mdoH NC_002655.2 1555090 1557633 D necessary for biosynthesis of osmoregulated periplasmic glucans possibly involved in the transfer to the periplasmic space; glucosyltransferase MdoH 1555090..1557633 Escherichia coli O157:H7 str. EDL933 959381 NP_287184.1 CDS yceK NC_002655.2 1557806 1558033 D hypothetical protein 1557806..1558033 Escherichia coli O157:H7 str. EDL933 959382 NP_287185.1 CDS msyB NC_002655.2 1558034 1558411 R hypothetical protein complement(1558034..1558411) Escherichia coli O157:H7 str. EDL933 959385 NP_287186.1 CDS Z1687 NC_002655.2 1558438 1558536 R hypothetical protein complement(1558438..1558536) Escherichia coli O157:H7 str. EDL933 959386 NP_287187.1 CDS yceE NC_002655.2 1558491 1559558 R hypothetical protein complement(1558491..1559558) Escherichia coli O157:H7 str. EDL933 959387 NP_287188.1 CDS Z1690 NC_002655.2 1559889 1560809 R Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis lauroyl acyltransferase complement(1559889..1560809) Escherichia coli O157:H7 str. EDL933 959388 NP_287189.1 CDS yceA NC_002655.2 1561034 1562086 D hypothetical protein 1561034..1562086 Escherichia coli O157:H7 str. EDL933 959389 NP_287190.1 CDS yceI NC_002655.2 1562128 1562703 R hypothetical protein complement(1562128..1562703) Escherichia coli O157:H7 str. EDL933 959391 NP_287191.1 CDS Z1693 NC_002655.2 1562707 1563273 R cytochrome complement(1562707..1563273) Escherichia coli O157:H7 str. EDL933 959393 NP_287192.1 CDS yceO NC_002655.2 1563534 1563674 R hypothetical protein complement(1563534..1563674) Escherichia coli O157:H7 str. EDL933 959395 NP_287193.1 CDS solA NC_002655.2 1563695 1564813 R catalyzes the demethylation of N-methyl-L-tryptophan forming L-tryptophan and formaldehyde; FAD-binding; can also catalyze the demethylation of other N-methyl amino acids; N-methyltryptophan oxidase complement(1563695..1564813) Escherichia coli O157:H7 str. EDL933 959396 NP_287194.1 CDS bssS NC_002655.2 1564928 1565182 R BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing; biofilm formation regulatory protein BssS complement(1564928..1565182) Escherichia coli O157:H7 str. EDL933 959397 NP_287195.1 CDS dinI NC_002655.2 1565472 1565717 R DNA damage-inducible protein I complement(1565472..1565717) Escherichia coli O157:H7 str. EDL933 959399 NP_287196.1 CDS pyrC NC_002655.2 1565791 1566837 R catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis; dihydroorotase complement(1565791..1566837) Escherichia coli O157:H7 str. EDL933 959400 NP_287197.1 CDS yceB NC_002655.2 1566943 1567503 R hypothetical protein complement(1566943..1567503) Escherichia coli O157:H7 str. EDL933 959401 NP_287198.1 CDS grxB NC_002655.2 1567637 1568284 R cofactor involved in the reduction of disulfides; glutaredoxin complement(1567637..1568284) Escherichia coli O157:H7 str. EDL933 959403 NP_287199.2 CDS yceL NC_002655.2 1568348 1569556 R Confers resistance to norfloxacin and enoxacin; multidrug resistance protein MdtH complement(1568348..1569556) Escherichia coli O157:H7 str. EDL933 959404 NP_287200.1 CDS rimJ NC_002655.2 1569792 1570376 D ribosomal-protein-S5-alanine N-acetyltransferase 1569792..1570376 Escherichia coli O157:H7 str. EDL933 959405 NP_287201.1 CDS yceH NC_002655.2 1570387 1571034 D hypothetical protein 1570387..1571034 Escherichia coli O157:H7 str. EDL933 959406 NP_287202.1 CDS mviM NC_002655.2 1571036 1571959 D virulence factor 1571036..1571959 Escherichia coli O157:H7 str. EDL933 959407 NP_287203.1 CDS mviN NC_002655.2 1572069 1573604 D virulence factor 1572069..1573604 Escherichia coli O157:H7 str. EDL933 959408 NP_287204.1 CDS flgN NC_002655.2 1573644 1574060 R flagellar synthesis protein FlgN complement(1573644..1574060) Escherichia coli O157:H7 str. EDL933 959409 NP_287205.1 CDS flgM NC_002655.2 1574065 1574358 R regulates the flagellar specific sigma28 transcription factor; anti-sigma-28 factor FlgM complement(1574065..1574358) Escherichia coli O157:H7 str. EDL933 959410 NP_287206.1 CDS flgA NC_002655.2 1574434 1575093 R required for the assembly of the flagellar basal body P-ring; flagellar basal body P-ring biosynthesis protein FlgA complement(1574434..1575093) Escherichia coli O157:H7 str. EDL933 959412 NP_287207.1 CDS flgB NC_002655.2 1575248 1575664 D with FlgF and C makes up the proximal portion of the flagellar basal body rod; Vibrio parahaemolyticus protein is associated with the polar flagella; flagellar basal-body rod protein FlgB 1575248..1575664 Escherichia coli O157:H7 str. EDL933 959413 NP_287208.1 CDS flgC NC_002655.2 1575668 1576072 D with FlgF and B makes up the proximal portion of the flagellar basal body rod; flagellar basal body rod protein FlgC 1575668..1576072 Escherichia coli O157:H7 str. EDL933 959415 NP_287209.1 CDS flgD NC_002655.2 1576084 1576779 D acts as a scaffold for the assembly of hook proteins onto the flagellar basal body rod; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of some flagellar genes; in V. parahaemolyticus one set used for lateral flagella production and the other is used for the polar flagella production; flagellar basal body rod modification protein 1576084..1576779 Escherichia coli O157:H7 str. EDL933 959416 NP_287210.1 CDS flgE NC_002655.2 1576804 1578009 D the hook connects flagellar basal body to the flagellar filament; flagellar hook protein FlgE 1576804..1578009 Escherichia coli O157:H7 str. EDL933 959417 NP_287211.1 CDS flgF NC_002655.2 1578029 1578784 D FlgF, with FlgB and C, makes up the proximal portion of the flagellar basal body rod; flagellar basal body rod protein FlgF 1578029..1578784 Escherichia coli O157:H7 str. EDL933 959418 NP_287212.1 CDS flgG NC_002655.2 1578922 1579704 D makes up the distal portion of the flagellar basal body rod; flagellar basal body rod protein FlgG 1578922..1579704 Escherichia coli O157:H7 str. EDL933 959421 NP_287213.1 CDS flgH NC_002655.2 1579757 1580455 D part of the flagellar basal body which consists of four rings L,P, S and M mounted on a central rod; flagellar basal body L-ring protein 1579757..1580455 Escherichia coli O157:H7 str. EDL933 959422 NP_287214.1 CDS flgI NC_002655.2 1580467 1581564 D part of the basal body which consists of four rings L, P, S, and M mounted on a central rod; Vibrio parahaemolyticus, Yersinia, Bradyrhizobium and other bacteria have two copies of this and other flagellar genes; the V. parahaemolyticus protein is associated with the polar flagella and the Bradyrhizobium protein is associated with the thick flagellum; flagellar basal body P-ring biosynthesis protein FlgA 1580467..1581564 Escherichia coli O157:H7 str. EDL933 959423 NP_287215.1 CDS flgJ NC_002655.2 1581564 1582505 D Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space; flagellar rod assembly protein/muramidase FlgJ 1581564..1582505 Escherichia coli O157:H7 str. EDL933 959424 NP_287216.1 CDS flgK NC_002655.2 1582571 1584214 D with FlgL acts as a hook filament junction protein to join the flagellar filament to the hook; flagellar hook-associated protein FlgK 1582571..1584214 Escherichia coli O157:H7 str. EDL933 959425 NP_287217.1 CDS flgL NC_002655.2 1584226 1585179 D with FlgK acts as a hook filament junction protein to join the flagellar filament to the hook; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of this and other flagellar genes; flagellar hook-associated protein FlgL 1584226..1585179 Escherichia coli O157:H7 str. EDL933 959427 NP_287218.1 CDS rne NC_002655.2 1585374 1588559 R bifunctional ribonuclease E/endoribonuclease/RNA-binding protein/RNA degradosome binding protein; forms part of the membrane-associated degradosome complex along with PNPase, RhlB, and enolase; ribonuclease E complement(1585374..1588559) Escherichia coli O157:H7 str. EDL933 959428 NP_287219.1 CDS Z1724 NC_002655.2 1588640 1589014 D hypothetical protein 1588640..1589014 Escherichia coli O157:H7 str. EDL933 959429 NP_287220.1 CDS yceC NC_002655.2 1589132 1590091 D catalyzes the transformation of uracil to pseudouracil at nucleotides U955, U2504, and U2580 in 23S rRNA; 23S rRNA pseudouridylate synthase C 1589132..1590091 Escherichia coli O157:H7 str. EDL933 959430 NP_287221.2 CDS maf NC_002655.2 1590192 1590776 R Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein complement(1590192..1590776) Escherichia coli O157:H7 str. EDL933 959431 NP_287222.1 CDS yceD NC_002655.2 1590975 1591496 D hypothetical protein 1590975..1591496 Escherichia coli O157:H7 str. EDL933 959432 NP_287223.1 CDS rpmF NC_002655.2 1591548 1591721 D some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 1591548..1591721 Escherichia coli O157:H7 str. EDL933 959433 NP_287224.2 CDS plsX NC_002655.2 1591802 1592872 D involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY; glycerol-3-phosphate acyltransferase PlsX 1591802..1592872 Escherichia coli O157:H7 str. EDL933 959434 NP_287225.1 CDS fabH NC_002655.2 1592940 1593893 D FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-ACP synthase 1592940..1593893 Escherichia coli O157:H7 str. EDL933 959435 NP_287226.1 CDS fabD NC_002655.2 1593909 1594838 D ACP S-malonyltransferase 1593909..1594838 Escherichia coli O157:H7 str. EDL933 959436 NP_287227.1 CDS fabG NC_002655.2 1594851 1595585 D catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 1594851..1595585 Escherichia coli O157:H7 str. EDL933 959437 NP_287228.1 CDS acpP NC_002655.2 1595796 1596032 D carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 1595796..1596032 Escherichia coli O157:H7 str. EDL933 959438 NP_287229.1 CDS fabF NC_002655.2 1596120 1597361 D FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase 1596120..1597361 Escherichia coli O157:H7 str. EDL933 959439 NP_287230.1 CDS pabC NC_002655.2 1597481 1598290 D catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate; 4-amino-4-deoxychorismate lyase 1597481..1598290 Escherichia coli O157:H7 str. EDL933 959440 NP_287231.1 CDS yceG NC_002655.2 1598293 1599315 D hypothetical protein 1598293..1599315 Escherichia coli O157:H7 str. EDL933 959444 NP_287232.1 CDS tmk NC_002655.2 1599305 1599946 D catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 1599305..1599946 Escherichia coli O157:H7 str. EDL933 959446 NP_287233.1 CDS holB NC_002655.2 1599943 1600947 D catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; DNA polymerase III subunit delta' 1599943..1600947 Escherichia coli O157:H7 str. EDL933 959447 NP_287234.1 CDS ycfH NC_002655.2 1600958 1601755 D metallodependent hydrolase 1600958..1601755 Escherichia coli O157:H7 str. EDL933 959448 NP_287235.1 CDS ptsG NC_002655.2 1602051 1603484 D phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system glucose-specific transporter subunit IIBC 1602051..1603484 Escherichia coli O157:H7 str. EDL933 959449 NP_287236.1 CDS fhuE NC_002655.2 1603544 1605733 R ferric-rhodotorulic acid outer membrane transporter complement(1603544..1605733) Escherichia coli O157:H7 str. EDL933 959453 NP_287237.1 CDS ycfF NC_002655.2 1606087 1606446 D purine nucleoside phosphoramidase 1606087..1606446 Escherichia coli O157:H7 str. EDL933 959454 NP_287238.1 CDS ycfL NC_002655.2 1606449 1606826 D hypothetical protein 1606449..1606826 Escherichia coli O157:H7 str. EDL933 959456 NP_287239.1 CDS ycfM NC_002655.2 1606840 1607481 D hypothetical protein 1606840..1607481 Escherichia coli O157:H7 str. EDL933 959457 NP_287240.1 CDS thiK NC_002655.2 1607462 1608286 D catalyzes the phosphorylation of thiamine to thiamine phosphate; thiamine kinase 1607462..1608286 Escherichia coli O157:H7 str. EDL933 959458 NP_287241.1 CDS ycfO NC_002655.2 1608297 1609322 D hydrolyzes the terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides; beta-hexosaminidase 1608297..1609322 Escherichia coli O157:H7 str. EDL933 959459 NP_287242.2 CDS ycfP NC_002655.2 1609345 1609887 D hypothetical protein 1609345..1609887 Escherichia coli O157:H7 str. EDL933 959460 NP_287243.1 CDS ndh NC_002655.2 1610288 1611592 D NADH dehydrogenase 1610288..1611592 Escherichia coli O157:H7 str. EDL933 959461 NP_287244.1 CDS ycfJ NC_002655.2 1611819 1612358 D hypothetical protein 1611819..1612358 Escherichia coli O157:H7 str. EDL933 959463 NP_287245.1 CDS ycfQ NC_002655.2 1612420 1613130 R hypothetical protein complement(1612420..1613130) Escherichia coli O157:H7 str. EDL933 959464 NP_287246.1 CDS ycfR NC_002655.2 1613293 1613550 D hypothetical protein 1613293..1613550 Escherichia coli O157:H7 str. EDL933 959465 NP_287247.1 CDS ycfS NC_002655.2 1613633 1614595 R hypothetical protein complement(1613633..1614595) Escherichia coli O157:H7 str. EDL933 959467 NP_287248.1 CDS mfd NC_002655.2 1614739 1618185 R transcription-repair coupling factor complement(1614739..1618185) Escherichia coli O157:H7 str. EDL933 959468 NP_287249.1 CDS ycfT NC_002655.2 1618313 1619386 R hypothetical protein complement(1618313..1619386) Escherichia coli O157:H7 str. EDL933 959469 NP_287250.1 CDS ycfU NC_002655.2 1619648 1620847 D part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane; outer membrane-specific lipoprotein transporter subunit LolC 1619648..1620847 Escherichia coli O157:H7 str. EDL933 959470 NP_287251.2 CDS lolD NC_002655.2 1620840 1621541 D outer membrane specific; part of transporter complex lolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone; lipoprotein transporter ATP-binding subunit 1620840..1621541 Escherichia coli O157:H7 str. EDL933 959471 NP_287252.1 CDS ycfW NC_002655.2 1621541 1622785 D part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane; outer membrane-specific lipoprotein transporter subunit LolE 1621541..1622785 Escherichia coli O157:H7 str. EDL933 959472 NP_287253.1 CDS ycfX NC_002655.2 1622814 1623725 D catalyzes the formation of N-acetyl-D-glucosamine-6-phosphate from N-acetyl-D-glucosamine; N-acetyl-D-glucosamine kinase 1622814..1623725 Escherichia coli O157:H7 str. EDL933 959473 NP_287254.1 CDS cobB NC_002655.2 1623741 1624562 D Modulates the activities of several enzymes which are inactive in their acetylated form; NAD-dependent deacetylase 1623741..1624562 Escherichia coli O157:H7 str. EDL933 959474 NP_287255.1 CDS potD NC_002655.2 1624718 1625764 R can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotD is a periplasmic component that binds the substrate; spermidine/putrescine ABC transporter substrate-binding protein complement(1624718..1625764) Escherichia coli O157:H7 str. EDL933 959475 NP_287256.1 CDS potC NC_002655.2 1625761 1626555 R can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotC is a membrane component; spermidine/putrescine ABC transporter complement(1625761..1626555) Escherichia coli O157:H7 str. EDL933 959476 NP_287257.1 CDS intN NC_002655.2 1626722 1627840 R hypothetical protein complement(1626722..1627840) Escherichia coli O157:H7 str. EDL933 959477 NP_287258.1 CDS xisN NC_002655.2 1627809 1628087 R No significant matches; excisionase complement(1627809..1628087) Escherichia coli O157:H7 str. EDL933 959478 NP_287259.1 CDS Z1766 NC_002655.2 1628140 1628484 R No significant matches; hypothetical protein complement(1628140..1628484) Escherichia coli O157:H7 str. EDL933 959480 NP_287260.1 CDS Z1768 NC_002655.2 1628545 1629177 D No significant matches; hypothetical protein 1628545..1629177 Escherichia coli O157:H7 str. EDL933 959481 NP_287261.1 CDS Z1769 NC_002655.2 1629292 1629522 R hypothetical protein complement(1629292..1629522) Escherichia coli O157:H7 str. EDL933 959482 NP_287262.1 CDS Z1770 NC_002655.2 1629760 1630236 R hypothetical protein complement(1629760..1630236) Escherichia coli O157:H7 str. EDL933 959483 NP_287263.1 CDS Z1771 NC_002655.2 1630361 1630684 D hypothetical protein 1630361..1630684 Escherichia coli O157:H7 str. EDL933 959484 NP_287264.1 CDS Z1772 NC_002655.2 1630668 1631093 D hypothetical protein 1630668..1631093 Escherichia coli O157:H7 str. EDL933 959485 NP_287265.1 CDS Z1773 NC_002655.2 1631162 1632199 D hypothetical protein 1631162..1632199 Escherichia coli O157:H7 str. EDL933 959486 NP_287266.1 CDS Z1774 NC_002655.2 1631991 1632653 D hypothetical protein 1631991..1632653 Escherichia coli O157:H7 str. EDL933 959487 NP_287267.1 CDS Z1775 NC_002655.2 1632687 1633403 D hypothetical protein 1632687..1633403 Escherichia coli O157:H7 str. EDL933 959488 NP_287268.1 CDS Z1776 NC_002655.2 1633400 1633717 D No significant matches; hypothetical protein 1633400..1633717 Escherichia coli O157:H7 str. EDL933 959489 NP_287269.1 CDS Z1777 NC_002655.2 1633714 1634016 D hypothetical protein 1633714..1634016 Escherichia coli O157:H7 str. EDL933 959490 NP_287270.1 CDS Z1778 NC_002655.2 1634006 1634323 D hypothetical protein 1634006..1634323 Escherichia coli O157:H7 str. EDL933 959491 NP_287271.1 CDS Z1779 NC_002655.2 1634277 1634594 D No significant matches; hypothetical protein 1634277..1634594 Escherichia coli O157:H7 str. EDL933 959492 NP_287272.1 CDS Z1780 NC_002655.2 1634581 1635018 D hypothetical protein 1634581..1635018 Escherichia coli O157:H7 str. EDL933 959493 NP_287273.1 CDS Z1781 NC_002655.2 1635214 1635801 D hypothetical protein 1635214..1635801 Escherichia coli O157:H7 str. EDL933 959499 NP_287274.1 CDS Z1782 NC_002655.2 1635917 1636021 D No significant matches; hypothetical protein 1635917..1636021 Escherichia coli O157:H7 str. EDL933 959501 NP_287275.1 CDS Z1783 NC_002655.2 1636210 1636422 D Gef-like protein encoded by prophage CP-933N 1636210..1636422 Escherichia coli O157:H7 str. EDL933 959503 NP_287276.1 CDS Z1784 NC_002655.2 1636870 1637919 D hypothetical protein 1636870..1637919 Escherichia coli O157:H7 str. EDL933 959505 NP_287277.1 CDS Z1785 NC_002655.2 1637932 1638303 D endodeoxyribonuclease of prophage CP-933N 1637932..1638303 Escherichia coli O157:H7 str. EDL933 959510 NP_287278.1 CDS Z1786 NC_002655.2 1638293 1638664 D Q antiterminator of prophage CP-933N 1638293..1638664 Escherichia coli O157:H7 str. EDL933 959511 NP_287279.1 CDS Z1787 NC_002655.2 1638810 1639634 D hypothetical protein 1638810..1639634 Escherichia coli O157:H7 str. EDL933 959512 NP_287280.1 CDS Z1788 NC_002655.2 1639921 1640160 D hypothetical protein 1639921..1640160 Escherichia coli O157:H7 str. EDL933 959513 NP_287281.1 CDS Z1789 NC_002655.2 1640255 1640968 D envelope protein encoded within prophage CP-933N 1640255..1640968 Escherichia coli O157:H7 str. EDL933 959517 NP_287282.1 CDS Z1793 NC_002655.2 1641736 1643589 D hypothetical protein 1641736..1643589 Escherichia coli O157:H7 str. EDL933 959534 NP_287283.1 CDS Z1794 NC_002655.2 1643640 1643954 D holin protein 1643640..1643954 Escherichia coli O157:H7 str. EDL933 959539 NP_287284.1 CDS Z1795 NC_002655.2 1643959 1644303 D hypothetical protein 1643959..1644303 Escherichia coli O157:H7 str. EDL933 959544 NP_287285.1 CDS Z1796 NC_002655.2 1644354 1644887 D endolysin of prophage CP-933N 1644354..1644887 Escherichia coli O157:H7 str. EDL933 959547 NP_287286.1 CDS Z1797 NC_002655.2 1645161 1645856 D antirepressor of prophage CP-933N 1645161..1645856 Escherichia coli O157:H7 str. EDL933 959548 NP_287287.1 CDS Z1798 NC_002655.2 1646079 1646552 D endopeptidase of prophage CP-933N 1646079..1646552 Escherichia coli O157:H7 str. EDL933 959549 NP_287288.1 CDS Z1799 NC_002655.2 1646885 1647217 D hypothetical protein 1646885..1647217 Escherichia coli O157:H7 str. EDL933 959550 NP_287289.1 CDS Z1800 NC_002655.2 1647591 1647956 D hypothetical protein 1647591..1647956 Escherichia coli O157:H7 str. EDL933 959551 NP_287290.1 CDS Z1802 NC_002655.2 1648245 1648808 D No significant matches; hypothetical protein 1648245..1648808 Escherichia coli O157:H7 str. EDL933 959553 NP_287291.1 CDS Z1803 NC_002655.2 1648805 1650466 D terminase encoded by prophage CP-933N 1648805..1650466 Escherichia coli O157:H7 str. EDL933 959554 NP_287292.1 CDS Z1804 NC_002655.2 1650530 1652467 D hypothetical protein 1650530..1652467 Escherichia coli O157:H7 str. EDL933 959555 NP_287293.1 CDS Z1805 NC_002655.2 1652512 1652733 D No significant matches; hypothetical protein 1652512..1652733 Escherichia coli O157:H7 str. EDL933 959556 NP_287294.1 CDS Z1806 NC_002655.2 1652679 1655258 D hypothetical protein 1652679..1655258 Escherichia coli O157:H7 str. EDL933 959557 NP_287295.1 CDS Z1807 NC_002655.2 1655261 1655587 D No significant matches; hypothetical protein 1655261..1655587 Escherichia coli O157:H7 str. EDL933 959559 NP_287296.1 CDS Z1808 NC_002655.2 1655744 1655947 D hypothetical protein 1655744..1655947 Escherichia coli O157:H7 str. EDL933 959562 NP_287297.1 CDS Z1809 NC_002655.2 1655944 1656390 D hypothetical protein 1655944..1656390 Escherichia coli O157:H7 str. EDL933 959564 NP_287298.1 CDS Z1810 NC_002655.2 1656387 1656731 D hypothetical protein 1656387..1656731 Escherichia coli O157:H7 str. EDL933 959566 NP_287299.1 CDS Z1811 NC_002655.2 1656728 1657513 D tail component encoded by prophage CP-933N 1656728..1657513 Escherichia coli O157:H7 str. EDL933 959567 NP_287300.1 CDS Z1812 NC_002655.2 1657480 1657902 D tail assembly chaperone encoded by prophage CP-933N 1657480..1657902 Escherichia coli O157:H7 str. EDL933 959568 NP_287301.1 CDS Z1813 NC_002655.2 1657926 1658207 D hypothetical protein 1657926..1658207 Escherichia coli O157:H7 str. EDL933 959569 NP_287302.1 CDS Z1814 NC_002655.2 1658259 1659452 D hypothetical protein 1658259..1659452 Escherichia coli O157:H7 str. EDL933 959570 NP_287303.1 CDS Z1815 NC_002655.2 1659673 1660371 D tail component L homolog encoded by prophage CP-933N 1659673..1660371 Escherichia coli O157:H7 str. EDL933 959572 NP_287304.1 CDS Z1816 NC_002655.2 1660546 1660704 D No significant matches; hypothetical protein 1660546..1660704 Escherichia coli O157:H7 str. EDL933 959573 NP_287305.1 CDS Z1817 NC_002655.2 1660751 1660861 D No significant matches; hypothetical protein 1660751..1660861 Escherichia coli O157:H7 str. EDL933 959574 NP_287306.1 CDS Z1818 NC_002655.2 1661164 1662042 D antirepressor protein encoded by prophage CP-933N 1661164..1662042 Escherichia coli O157:H7 str. EDL933 959576 NP_287307.1 CDS Z1819 NC_002655.2 1662096 1662833 D tail component K homolog encoded by prophage CP-933N 1662096..1662833 Escherichia coli O157:H7 str. EDL933 959578 NP_287308.1 CDS Z1820 NC_002655.2 1662830 1663015 D hypothetical protein 1662830..1663015 Escherichia coli O157:H7 str. EDL933 959579 NP_287309.1 CDS Z1821 NC_002655.2 1663272 1663508 R No significant matches; hypothetical protein complement(1663272..1663508) Escherichia coli O157:H7 str. EDL933 959580 NP_287310.1 CDS Z1822 NC_002655.2 1663537 1665486 D hypothetical protein 1663537..1665486 Escherichia coli O157:H7 str. EDL933 959581 NP_287311.1 CDS Z1823 NC_002655.2 1666077 1666661 D No significant matches; hypothetical protein 1666077..1666661 Escherichia coli O157:H7 str. EDL933 959582 NP_287312.1 CDS Z1824 NC_002655.2 1666666 1669479 D hypothetical protein 1666666..1669479 Escherichia coli O157:H7 str. EDL933 959583 NP_287313.1 CDS Z1825 NC_002655.2 1670022 1670927 R IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD complement(1670022..1670927) Escherichia coli O157:H7 str. EDL933 959585 NP_287314.1 CDS Z1826 NC_002655.2 1671089 1671250 R IS encoded protein complement(1671089..1671250) Escherichia coli O157:H7 str. EDL933 959586 NP_287315.1 CDS Z1827 NC_002655.2 1671207 1671560 D IS encoded protein 1671207..1671560 Escherichia coli O157:H7 str. EDL933 959587 NP_287316.1 CDS Z1829 NC_002655.2 1672124 1673485 R No significant matches; hypothetical protein complement(1672124..1673485) Escherichia coli O157:H7 str. EDL933 959588 NP_287317.1 CDS potB NC_002655.2 1673849 1674712 R can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotB is a membrane component; spermidine/putrescine ABC transporter complement(1673849..1674712) Escherichia coli O157:H7 str. EDL933 959589 NP_287318.1 CDS potA NC_002655.2 1674696 1675832 R functions together with PotBCD (A2BCD) in ATP-dependent polyamine transport; PotA is the membrane-associated ATPase; putrescine/spermidine ABC transporter ATPase complement(1674696..1675832) Escherichia coli O157:H7 str. EDL933 959590 NP_287319.1 CDS pepT NC_002655.2 1676082 1677308 D catalyzes the release of the N-terminal amino acid from a tripeptide; peptidase T 1676082..1677308 Escherichia coli O157:H7 str. EDL933 959591 NP_287320.1 CDS ycfD NC_002655.2 1677357 1678487 R hypothetical protein complement(1677357..1678487) Escherichia coli O157:H7 str. EDL933 959592 NP_287321.1 CDS Z1835 NC_002655.2 1678706 1679956 D integrase of prophage CP-933C 1678706..1679956 Escherichia coli O157:H7 str. EDL933 959593 NP_287323.1 CDS Z1838 NC_002655.2 1680376 1680546 R No significant matches; hypothetical protein complement(1680376..1680546) Escherichia coli O157:H7 str. EDL933 959595 NP_287324.1 CDS Z1839 NC_002655.2 1681010 1681141 R No significant matches; hypothetical protein complement(1681010..1681141) Escherichia coli O157:H7 str. EDL933 959596 NP_287325.1 CDS Z1840 NC_002655.2 1681526 1681711 D No significant matches; hypothetical protein 1681526..1681711 Escherichia coli O157:H7 str. EDL933 959597 NP_287326.1 CDS Z1841 NC_002655.2 1681874 1682134 D No significant matches; hypothetical protein 1681874..1682134 Escherichia coli O157:H7 str. EDL933 959598 NP_287327.1 CDS Z1842 NC_002655.2 1682436 1683410 D No significant matches; hypothetical protein 1682436..1683410 Escherichia coli O157:H7 str. EDL933 959599 NP_287328.1 CDS Z1843 NC_002655.2 1683407 1684567 D No significant matches; hypothetical protein 1683407..1684567 Escherichia coli O157:H7 str. EDL933 959600 NP_287329.1 CDS Z1844 NC_002655.2 1684938 1685189 D No significant matches; hypothetical protein 1684938..1685189 Escherichia coli O157:H7 str. EDL933 959601 NP_287330.1 CDS Z1845 NC_002655.2 1685186 1685596 D ssDNA-binding protein 1685186..1685596 Escherichia coli O157:H7 str. EDL933 959602 NP_287331.1 CDS Z1846 NC_002655.2 1685926 1686228 D No significant matches; hypothetical protein 1685926..1686228 Escherichia coli O157:H7 str. EDL933 959603 NP_287332.1 CDS Z1847 NC_002655.2 1686521 1687678 D capsid protein of prophage CP-933C 1686521..1687678 Escherichia coli O157:H7 str. EDL933 959604 NP_287333.1 CDS Z1848 NC_002655.2 1687718 1688290 D head maturation protease of prophage CP-933C 1687718..1688290 Escherichia coli O157:H7 str. EDL933 959605 NP_287334.1 CDS Z1849 NC_002655.2 1688292 1689503 D portal protein of prophage CP-933C 1688292..1689503 Escherichia coli O157:H7 str. EDL933 959607 NP_287335.1 CDS Z1850 NC_002655.2 1689595 1689876 R No significant matches; hypothetical protein complement(1689595..1689876) Escherichia coli O157:H7 str. EDL933 959608 NP_287336.1 CDS Z1851 NC_002655.2 1689835 1690131 D hypothetical protein 1689835..1690131 Escherichia coli O157:H7 str. EDL933 959610 NP_287337.1 CDS Z1852 NC_002655.2 1690182 1690571 D holin protein of prophage CP-933C 1690182..1690571 Escherichia coli O157:H7 str. EDL933 959611 NP_287338.1 CDS Z1853 NC_002655.2 1690861 1691217 D hypothetical protein 1690861..1691217 Escherichia coli O157:H7 str. EDL933 959612 NP_287339.1 CDS Z1854 NC_002655.2 1691333 1692862 D terminase of prophage CP-933C 1691333..1692862 Escherichia coli O157:H7 str. EDL933 959613 NP_287340.1 CDS Z1855 NC_002655.2 1692876 1693157 D No significant matches; hypothetical protein 1692876..1693157 Escherichia coli O157:H7 str. EDL933 959614 NP_287341.1 CDS Z1856 NC_002655.2 1692900 1693238 R No significant matches; hypothetical protein complement(1692900..1693238) Escherichia coli O157:H7 str. EDL933 959615 NP_287342.1 CDS Z1857 NC_002655.2 1693462 1693737 R No significant matches; hypothetical protein complement(1693462..1693737) Escherichia coli O157:H7 str. EDL933 959616 NP_287343.1 CDS phoQ NC_002655.2 1694014 1695396 R sensor protein PhoQ complement(1694014..1695396) Escherichia coli O157:H7 str. EDL933 959617 NP_287344.1 CDS phoP NC_002655.2 1695474 1696145 R response regulator in two-component regulatory system with PhoQ; involved in magnesium starvation and stress; DNA-binding transcriptional regulator PhoP complement(1695474..1696145) Escherichia coli O157:H7 str. EDL933 959618 NP_287345.1 CDS purB NC_002655.2 1696314 1697684 R Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase complement(1696314..1697684) Escherichia coli O157:H7 str. EDL933 959619 NP_287346.1 CDS ycfC NC_002655.2 1697688 1698329 R HflD; UPF0274; in Escherichia coli this protein is peripherally associated with the membrane and appears to act with lambda CII protein; in Haemophilus influenzae a knockout of the HI0638 gene affected paracytosis; hypothetical protein complement(1697688..1698329) Escherichia coli O157:H7 str. EDL933 959647 NP_287347.2 CDS mnmA NC_002655.2 1698365 1699471 R catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA complement(1698365..1699471) Escherichia coli O157:H7 str. EDL933 959790 NP_287348.1 CDS Z1863 NC_002655.2 1699525 1699986 R phosphohydrolase complement(1699525..1699986) Escherichia coli O157:H7 str. EDL933 959806 NP_287349.1 CDS ymfC NC_002655.2 1699996 1700619 R catalyzes the formation of pseudouridine from uracil-2457 in 23S ribosomal RNA; 23S rRNA pseudouridine synthase E complement(1699996..1700619) Escherichia coli O157:H7 str. EDL933 959820 NP_287350.1 CDS icdA NC_002655.2 1700821 1702071 D Converts isocitrate to alpha ketoglutarate; isocitrate dehydrogenase 1700821..1702071 Escherichia coli O157:H7 str. EDL933 959821 NP_287351.1 CDS Z1866 NC_002655.2 1702185 1703327 R integrase of prophage CP-933X complement(1702185..1703327) Escherichia coli O157:H7 str. EDL933 959822 NP_287352.1 CDS Z1867 NC_002655.2 1703317 1703553 R integrase of prophage CP-933X complement(1703317..1703553) Escherichia coli O157:H7 str. EDL933 959823 NP_287353.1 CDS Z1868 NC_002655.2 1703657 1704400 D replication protein O of prophage CP-933X 1703657..1704400 Escherichia coli O157:H7 str. EDL933 959824 NP_287354.1 CDS Z1869 NC_002655.2 1704516 1705181 D replication protein P of prophage CP-933X 1704516..1705181 Escherichia coli O157:H7 str. EDL933 959825 NP_287355.1 CDS emrE NC_002655.2 1705548 1705880 D member of the small MDR (multidrug resistance) family of transporters; in Escherichia coli this protein provides resistance against a number of positively charged compounds including ethidium bromide and erythromycin; proton-dependent secondary transporter which exchanges protons for compound translocation; multidrug efflux protein 1705548..1705880 Escherichia coli O157:H7 str. EDL933 959826 NP_287356.1 CDS Z1871 NC_002655.2 1706125 1707651 D hypothetical protein 1706125..1707651 Escherichia coli O157:H7 str. EDL933 959827 NP_287357.1 CDS ybcN NC_002655.2 1708153 1708608 D DLP12 prophage; hypothetical protein 1708153..1708608 Escherichia coli O157:H7 str. EDL933 959828 NP_287358.1 CDS rus NC_002655.2 1709058 1709420 D DLP12 prophage; Holliday junction resolvase; endodeoxyribonuclease RUS 1709058..1709420 Escherichia coli O157:H7 str. EDL933 959829 NP_287359.1 CDS Z1874 NC_002655.2 1709554 1710243 D antiterminator Q of prophage CP-933X 1709554..1710243 Escherichia coli O157:H7 str. EDL933 959830 NP_287360.1 CDS Z1875 NC_002655.2 1710565 1710870 D holin protein of prophage CP-933X 1710565..1710870 Escherichia coli O157:H7 str. EDL933 959831 NP_287361.1 CDS Z1876 NC_002655.2 1710857 1711333 D endolysin of prophage CP-933X 1710857..1711333 Escherichia coli O157:H7 str. EDL933 959832 NP_287362.1 CDS Z1877 NC_002655.2 1711474 1711791 D endopeptidase of prophage CP-933X 1711474..1711791 Escherichia coli O157:H7 str. EDL933 959833 NP_287363.1 CDS Z1878 NC_002655.2 1711823 1712116 R Bor protein of prophage CP-933X complement(1711823..1712116) Escherichia coli O157:H7 str. EDL933 959834 NP_287364.1 CDS Z1879 NC_002655.2 1712408 1712860 R envelope protein of prophage CP-933X complement(1712408..1712860) Escherichia coli O157:H7 str. EDL933 959835 NP_287365.1 CDS Z1880 NC_002655.2 1713104 1713310 D hypothetical protein 1713104..1713310 Escherichia coli O157:H7 str. EDL933 959836 NP_287366.1 CDS Z1881 NC_002655.2 1713475 1713669 R hypothetical protein complement(1713475..1713669) Escherichia coli O157:H7 str. EDL933 959837 NP_287367.1 CDS Z1882 NC_002655.2 1714058 1714603 D DNA packaging protein of prophage CP-933X 1714058..1714603 Escherichia coli O157:H7 str. EDL933 959838 NP_287368.1 CDS Z1883 NC_002655.2 1714578 1716503 D DNA packaging protein of prophage CP-933X 1714578..1716503 Escherichia coli O157:H7 str. EDL933 959839 NP_287369.1 CDS Z1884 NC_002655.2 1716551 1716706 D head-tail joining protein of prophage CP-933X 1716551..1716706 Escherichia coli O157:H7 str. EDL933 959840 NP_287370.1 CDS Z1885 NC_002655.2 1716703 1718304 D capsid structural protein of prophage CP-933X 1716703..1718304 Escherichia coli O157:H7 str. EDL933 959841 NP_287371.1 CDS Z1886 NC_002655.2 1718285 1719604 D capsid protein of prophage CP-933X 1718285..1719604 Escherichia coli O157:H7 str. EDL933 959843 NP_287372.2 CDS Z1887 NC_002655.2 1719608 >1719952 D head-DNA stabilization protein of prophage CP-933X 1719608..>1719952 Escherichia coli O157:H7 str. EDL933 959844 NP_287373.1 CDS Z1888 NC_002655.2 1720003 1721028 D capsid protein of prophage CP-933X 1720003..1721028 Escherichia coli O157:H7 str. EDL933 959845 NP_287374.1 CDS Z1889 NC_002655.2 1721031 1721468 D DNA packaging protein of prophage CP-933X 1721031..1721468 Escherichia coli O157:H7 str. EDL933 959846 NP_287375.1 CDS Z1890 NC_002655.2 1721480 1721833 D head-tail joining protein of prophage CP-933X 1721480..1721833 Escherichia coli O157:H7 str. EDL933 959847 NP_287376.1 CDS Z1891 NC_002655.2 1722178 1722423 D tail component of prophage CP-933X 1722178..1722423 Escherichia coli O157:H7 str. EDL933 959848 NP_287377.1 CDS Z1893 NC_002655.2 1722420 1722815 D tail component of prophage CP-933X 1722420..1722815 Escherichia coli O157:H7 str. EDL933 959849 NP_287378.1 CDS Z1894 NC_002655.2 1722793 1723563 D tail component of prophage CP-933X 1722793..1723563 Escherichia coli O157:H7 str. EDL933 959850 NP_287379.1 CDS Z1895 NC_002655.2 1723579 1724001 D tail component of prophage CP-933X 1723579..1724001 Escherichia coli O157:H7 str. EDL933 959851 NP_287380.1 CDS Z1896 NC_002655.2 1723983 1724417 D tail component of prophage CP-933X 1723983..1724417 Escherichia coli O157:H7 str. EDL933 959852 NP_287381.1 CDS Z1898 NC_002655.2 1724410 >1725748 D tail component of prophage CP-933X 1724410..>1725748 Escherichia coli O157:H7 str. EDL933 959853 NP_287382.1 CDS Z1901 NC_002655.2 1730065 1730391 D No significant matches; hypothetical protein 1730065..1730391 Escherichia coli O157:H7 str. EDL933 959854 NP_287383.1 CDS Z1902 NC_002655.2 1730401 1730751 D head-tail adaptor of prophage CP-933X 1730401..1730751 Escherichia coli O157:H7 str. EDL933 959855 NP_287384.1 CDS Z1903 NC_002655.2 1730748 1730993 D hypothetical protein 1730748..1730993 Escherichia coli O157:H7 str. EDL933 959856 NP_287385.1 CDS Z1905 NC_002655.2 1730929 1731195 D hypothetical protein 1730929..1731195 Escherichia coli O157:H7 str. EDL933 959857 NP_287386.1 CDS Z1906 NC_002655.2 1731192 1731536 D hypothetical protein 1731192..1731536 Escherichia coli O157:H7 str. EDL933 959858 NP_287387.1 CDS Z1908 NC_002655.2 1731533 1732321 D tail component of prophage CP-933X 1731533..1732321 Escherichia coli O157:H7 str. EDL933 959859 NP_287388.1 CDS Z1910 NC_002655.2 1732327 1732569 D hypothetical protein 1732327..1732569 Escherichia coli O157:H7 str. EDL933 959860 NP_287389.1 CDS Z1912 NC_002655.2 1732727 1733008 D hypothetical protein 1732727..1733008 Escherichia coli O157:H7 str. EDL933 959861 NP_287390.1 CDS Z1913 NC_002655.2 1733056 1736136 D tail component of prophage CP-933X 1733056..1736136 Escherichia coli O157:H7 str. EDL933 959862 NP_287391.1 CDS Z1914 NC_002655.2 1736470 1736907 D minor tail fiber protein of prophage CP-933X 1736470..1736907 Escherichia coli O157:H7 str. EDL933 959863 NP_287392.1 CDS Z1915 NC_002655.2 1737105 1738271 D tail protein (partial) of prophage CP-933X 1737105..1738271 Escherichia coli O157:H7 str. EDL933 959864 NP_287393.1 CDS Z1916 NC_002655.2 1738220 1740568 D tail protein (partial) of prophage CP-933X 1738220..1740568 Escherichia coli O157:H7 str. EDL933 959865 NP_287394.1 CDS Z1917 NC_002655.2 1740636 1741235 D prophage protein 1740636..1741235 Escherichia coli O157:H7 str. EDL933 959866 NP_287395.1 CDS Z1918 NC_002655.2 1741294 1744215 D membrane protein of prophage CP-933X 1741294..1744215 Escherichia coli O157:H7 str. EDL933 959867 NP_287396.1 CDS Z1919 NC_002655.2 1741797 1742546 R hypothetical protein complement(1741797..1742546) Escherichia coli O157:H7 str. EDL933 959869 NP_287397.1 CDS Z1920 NC_002655.2 1744215 1744796 D tail fiber protein of prophage CP-933X 1744215..1744796 Escherichia coli O157:H7 str. EDL933 959870 NP_287398.1 CDS Z1921 NC_002655.2 1744916 1745806 R hypothetical protein complement(1744916..1745806) Escherichia coli O157:H7 str. EDL933 959871 NP_287399.1 CDS Z1922 NC_002655.2 1745825 1746331 R hypothetical protein complement(1745825..1746331) Escherichia coli O157:H7 str. EDL933 959872 NP_287400.1 CDS Z1923 NC_002655.2 1746368 1746874 R hypothetical protein complement(1746368..1746874) Escherichia coli O157:H7 str. EDL933 959873 NP_287401.1 CDS Z1924 NC_002655.2 1746947 1747129 R hypothetical protein complement(1746947..1747129) Escherichia coli O157:H7 str. EDL933 959874 NP_287402.1 CDS Z1925 NC_002655.2 1747627 1748295 R hypothetical protein complement(1747627..1748295) Escherichia coli O157:H7 str. EDL933 959875 NP_287403.1 CDS Z1926 NC_002655.2 1748352 1748600 D hypothetical protein 1748352..1748600 Escherichia coli O157:H7 str. EDL933 959876 NP_287404.1 CDS Z1927 NC_002655.2 1748655 1749113 D hypothetical protein 1748655..1749113 Escherichia coli O157:H7 str. EDL933 959877 NP_287405.1 CDS Z1928 NC_002655.2 1749317 1749409 D hypothetical protein 1749317..1749409 Escherichia coli O157:H7 str. EDL933 959878 NP_287406.1 CDS Z1929 NC_002655.2 1749459 1750997 D hypothetical protein 1749459..1750997 Escherichia coli O157:H7 str. EDL933 959879 NP_287407.1 CDS Z1930 NC_002655.2 1751300 1752784 R protease encoded within prophage CP-933X complement(1751300..1752784) Escherichia coli O157:H7 str. EDL933 959880 NP_287408.1 CDS Z1931 NC_002655.2 1752971 1753924 R outer membrane protease; involved in virulence in many organisms; OmpT; IcsP; SopA; Pla; PgtE; omptin; in Escherichia coli OmpT can degrade antimicrobial peptides; in Yersinia Pla activates plasminogen during infection; in Shigella flexneria SopA cleaves the autotransporter IcsA; outer membrane protease complement(1752971..1753924) Escherichia coli O157:H7 str. EDL933 959882 NP_287409.1 CDS Z1932 NC_002655.2 1754406 1754741 D hypothetical protein 1754406..1754741 Escherichia coli O157:H7 str. EDL933 959883 NP_287410.1 CDS Z1933 NC_002655.2 1754793 1755119 D hypothetical protein 1754793..1755119 Escherichia coli O157:H7 str. EDL933 959884 NP_287411.1 CDS Z1934 NC_002655.2 1755359 1756006 D transposase for IS629 1755359..1756006 Escherichia coli O157:H7 str. EDL933 959885 NP_287412.1 CDS Z1935 NC_002655.2 1756588 1756800 D hypothetical protein 1756588..1756800 Escherichia coli O157:H7 str. EDL933 959886 NP_287413.1 CDS minE NC_002655.2 1757172 1757438 R works in conjunction with MinC and MinD to enable cell division at the midpoint of the long axis of the cell; cell division topological specificity factor MinE complement(1757172..1757438) Escherichia coli O157:H7 str. EDL933 959887 NP_287414.1 CDS minD NC_002655.2 1757442 1758254 R ATPase; with MinC inhibits cell division by blocking formation of the polar Z ring septums; cell division inhibitor MinD complement(1757442..1758254) Escherichia coli O157:H7 str. EDL933 959888 NP_287415.1 CDS minC NC_002655.2 1758278 1758973 R blocks the formation of polar Z-ring septums; septum formation inhibitor complement(1758278..1758973) Escherichia coli O157:H7 str. EDL933 959889 NP_287416.1 CDS ycgJ NC_002655.2 1759493 1759861 D hypothetical protein 1759493..1759861 Escherichia coli O157:H7 str. EDL933 959890 NP_287417.1 CDS ycgK NC_002655.2 1759964 1760365 R hypothetical protein complement(1759964..1760365) Escherichia coli O157:H7 str. EDL933 959891 NP_287418.1 CDS ycgL NC_002655.2 1760574 1760900 D hypothetical protein 1760574..1760900 Escherichia coli O157:H7 str. EDL933 959892 NP_287419.1 CDS Z1942 NC_002655.2 1760972 1761631 D hypothetical protein 1760972..1761631 Escherichia coli O157:H7 str. EDL933 959893 NP_287420.2 CDS ycgN NC_002655.2 1761723 1762169 D hypothetical protein 1761723..1762169 Escherichia coli O157:H7 str. EDL933 959894 NP_287421.1 CDS hlyE NC_002655.2 1762376 1763293 R Acts by forming a pore-like structure upon contact with mammalian cells; hemolysin E complement(1762376..1763293) Escherichia coli O157:H7 str. EDL933 959895 NP_287422.1 CDS umuD NC_002655.2 1763660 1764079 D binds with UmuC protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization; DNA polymerase V subunit UmuD 1763660..1764079 Escherichia coli O157:H7 str. EDL933 959896 NP_287423.1 CDS umuC NC_002655.2 1764079 1765347 D binds processed UmuD protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization; DNA polymerase V subunit UmuC 1764079..1765347 Escherichia coli O157:H7 str. EDL933 959897 NP_287424.1 CDS dsbB NC_002655.2 1765393 1765923 R disulfide oxidoreductase; integral membrane protein; required for perioplasmic disulfide bond formation; oxidizes DsbA protein; disulfide bond formation protein B complement(1765393..1765923) Escherichia coli O157:H7 str. EDL933 959898 NP_287425.1 CDS nhaB NC_002655.2 1766069 1767610 R involved in regulation of intracellular pH under alkaline conditions; sodium/proton antiporter complement(1766069..1767610) Escherichia coli O157:H7 str. EDL933 959899 NP_287426.1 CDS fadR NC_002655.2 1767832 1768551 D Multifunctional regulator of fatty acid metabolism; fatty acid metabolism regulator 1767832..1768551 Escherichia coli O157:H7 str. EDL933 959900 NP_287427.1 CDS ycgB NC_002655.2 1768603 1770135 R SpoVR family protein complement(1768603..1770135) Escherichia coli O157:H7 str. EDL933 959901 NP_287428.1 CDS dadA NC_002655.2 1770498 1771796 D catalyzes the oxidative deamination of D-amino acids; D-amino acid dehydrogenase small subunit 1770498..1771796 Escherichia coli O157:H7 str. EDL933 960218 NP_287429.1 CDS dadX NC_002655.2 1771806 1772876 D catabolic enzyme, converts L-alanine to D-alanine which is then oxidized to pyruvate by dadA; alanine racemase 1771806..1772876 Escherichia coli O157:H7 str. EDL933 960219 NP_287430.2 CDS Z1954 NC_002655.2 1773268 1775004 R the Vibrio parahaemolyticus gene VP2867 was found to be a potassium/proton antiporter; can rapidly extrude potassium against a potassium gradient at alkaline pH when cloned and expressed in Escherichia coli; potassium/proton antiporter complement(1773268..1775004) Escherichia coli O157:H7 str. EDL933 960225 NP_287431.1 CDS ldcA NC_002655.2 1775100 1776014 R catalyzes the release of D-alanine from L-alanyl-D-glutamyl-meso-diaminopimelyl-D-alanine; L,D-carboxypeptidase A complement(1775100..1776014) Escherichia coli O157:H7 str. EDL933 960229 NP_287432.1 CDS mltE NC_002655.2 1776000 1776725 D murein transglycosylase E 1776000..1776725 Escherichia coli O157:H7 str. EDL933 960231 NP_287433.1 CDS Z1957 NC_002655.2 1776913 1777803 R transposase for IS629 complement(1776913..1777803) Escherichia coli O157:H7 str. EDL933 960242 NP_287434.1 CDS Z1958 NC_002655.2 1777800 1778126 R hypothetical protein complement(1777800..1778126) Escherichia coli O157:H7 str. EDL933 960334 NP_287435.1 CDS ycgR NC_002655.2 1778178 1778774 R hypothetical protein complement(1778178..1778774) Escherichia coli O157:H7 str. EDL933 960358 NP_287436.1 CDS ymgE NC_002655.2 1778975 1779229 D hypothetical protein 1778975..1779229 Escherichia coli O157:H7 str. EDL933 960379 NP_287437.1 CDS prrA NC_002655.2 1779279 1781249 R TonB dependent outer membrane receptor complement(1779279..1781249) Escherichia coli O157:H7 str. EDL933 960384 NP_287438.1 CDS modD NC_002655.2 1781275 1782129 R involved in molybdenum transport; molybdenum transport protein ModD complement(1781275..1782129) Escherichia coli O157:H7 str. EDL933 960430 NP_287439.1 CDS Z1963 NC_002655.2 1782294 1782938 R hypothetical protein complement(1782294..1782938) Escherichia coli O157:H7 str. EDL933 960437 NP_287440.1 CDS Z1964 NC_002655.2 1782948 1783706 R iron ABC transporter ATP-binding protein complement(1782948..1783706) Escherichia coli O157:H7 str. EDL933 960440 NP_287441.1 CDS Z1965 NC_002655.2 1783703 1784683 R iron ABC transporter permease complement(1783703..1784683) Escherichia coli O157:H7 str. EDL933 960443 NP_287442.1 CDS Z1966 NC_002655.2 1784683 1785705 R hypothetical protein complement(1784683..1785705) Escherichia coli O157:H7 str. EDL933 960444 NP_287443.1 CDS Z1967 NC_002655.2 1785813 1786013 R No significant matches; hypothetical protein complement(1785813..1786013) Escherichia coli O157:H7 str. EDL933 960445 NP_287444.1 CDS treA NC_002655.2 1786041 1787498 R trehalase, periplasmic complement(1786041..1787498) Escherichia coli O157:H7 str. EDL933 960446 NP_287445.1 CDS ycgC NC_002655.2 1788045 1789466 R phosphotransferaese subunit; phosphorylates dihydroxyacetone along with DhaK/DhaL; dihydroxyacetone kinase subunit DhaM complement(1788045..1789466) Escherichia coli O157:H7 str. EDL933 960447 NP_287446.1 CDS Z1970 NC_002655.2 1789474 1790106 R with DhaK and DhaM catalyzes the phosphorylation of dihydroxyacetone; dihydroxyacetone kinase subunit DhaL complement(1789474..1790106) Escherichia coli O157:H7 str. EDL933 960449 NP_287447.1 CDS Z1971 NC_002655.2 1790117 1791217 R with DhaL and DhaM forms dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone; DhaK is the dihydroxyacetone binding subunit of the dihydroxyacetone kinase; dihydroxyacetone kinase subunit DhaK complement(1790117..1791217) Escherichia coli O157:H7 str. EDL933 960450 NP_287448.1 CDS Z1972 NC_002655.2 1791522 1793165 R adhesion protein complement(1791522..1793165) Escherichia coli O157:H7 str. EDL933 960451 NP_287449.1 CDS ychF NC_002655.2 1794009 1795100 R translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD complement(1794009..1795100) Escherichia coli O157:H7 str. EDL933 960453 NP_287450.1 CDS pth NC_002655.2 1795217 1795801 R Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase complement(1795217..1795801) Escherichia coli O157:H7 str. EDL933 960454 NP_287451.1 CDS ychH NC_002655.2 1796079 1796357 D YchH; transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria; ychH presents a class II promoter to bind CRP; unknown function; hypothetical protein 1796079..1796357 Escherichia coli O157:H7 str. EDL933 960455 NP_287452.1 CDS ychM NC_002655.2 1796412 1798064 R role in sulfate transport across the inner membrane; member of the SulP family of sulfate transporters; seems to mediate transport via sulfate/proton symport; sulfate transporter YchM complement(1796412..1798064) Escherichia coli O157:H7 str. EDL933 960456 NP_287453.1 CDS prsA NC_002655.2 1798216 1799163 R catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase complement(1798216..1799163) Escherichia coli O157:H7 str. EDL933 960457 NP_287454.1 CDS ipk NC_002655.2 1799314 1800165 R An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase complement(1799314..1800165) Escherichia coli O157:H7 str. EDL933 960458 NP_287455.1 CDS lolB NC_002655.2 1800165 1800788 R Incorporates lipoproteins in the outer membrane after they are released by the LolA protein; molecular chaperone LolB complement(1800165..1800788) Escherichia coli O157:H7 str. EDL933 960459 NP_287456.1 CDS hemA NC_002655.2 1801002 1802258 D catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins; glutamyl-tRNA reductase 1801002..1802258 Escherichia coli O157:H7 str. EDL933 960460 NP_287457.1 CDS prfA NC_002655.2 1802300 1803382 D recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 1802300..1803382 Escherichia coli O157:H7 str. EDL933 960461 NP_287458.1 CDS hemK NC_002655.2 1803382 1804215 D HemK; PrmC; transfers a methyl group from S-adenosylmethionine to amide nitrogen of specific glutamine residues in protein chain release factors PrfA and PrfB; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase 1803382..1804215 Escherichia coli O157:H7 str. EDL933 960462 NP_287459.1 CDS Z1984 NC_002655.2 1804212 1804604 D transcriptional regulator 1804212..1804604 Escherichia coli O157:H7 str. EDL933 960463 NP_287460.1 CDS ychA NC_002655.2 1804608 1805417 D transcriptional regulator 1804608..1805417 Escherichia coli O157:H7 str. EDL933 960464 NP_287461.1 CDS kdsA NC_002655.2 1805453 1806307 D catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis; 2-dehydro-3-deoxyphosphooctonate aldolase 1805453..1806307 Escherichia coli O157:H7 str. EDL933 960465 NP_287462.1 CDS Z1987 NC_002655.2 1806455 1806589 R No significant matches; hypothetical protein complement(1806455..1806589) Escherichia coli O157:H7 str. EDL933 960466 NP_287463.1 CDS Z1989 NC_002655.2 1806991 1807125 R No significant matches; hypothetical protein complement(1806991..1807125) Escherichia coli O157:H7 str. EDL933 960467 NP_287464.1 CDS chaA NC_002655.2 1808027 1809127 R calcium/sodium:proton antiporter complement(1808027..1809127) Escherichia coli O157:H7 str. EDL933 960468 NP_287465.1 CDS chaB NC_002655.2 1809397 1809627 D in Escherichia coli this protein ly regulates the sodium/proton (also pH-independent calcium/proton) antiporter chaA; has weak affinity for calcium and magnesium ions; cation transport regulator 1809397..1809627 Escherichia coli O157:H7 str. EDL933 960469 NP_287466.1 CDS chaC NC_002655.2 1809788 1810483 D cation transport regulator 1809788..1810483 Escherichia coli O157:H7 str. EDL933 960470 NP_287467.1 CDS ychN NC_002655.2 1810527 1810880 R hypothetical protein complement(1810527..1810880) Escherichia coli O157:H7 str. EDL933 960471 NP_287468.1 CDS ychP NC_002655.2 1811207 1812460 D hypothetical protein 1811207..1812460 Escherichia coli O157:H7 str. EDL933 960472 NP_287469.1 CDS narL NC_002655.2 1812461 1813111 R two-component response regulator NarL; phosphorylated by NarQ; activates transcription of nitrate and nitrite reductase genes and represses transcription of fumarate reductase; transcriptional regulator NarL complement(1812461..1813111) Escherichia coli O157:H7 str. EDL933 960473 NP_287470.1 CDS narX NC_002655.2 1813104 1814900 R nitrate/nitrite sensor protein NarX complement(1813104..1814900) Escherichia coli O157:H7 str. EDL933 960474 NP_287471.1 CDS narK NC_002655.2 1815239 1816630 D nitrite extrusion protein 1815239..1816630 Escherichia coli O157:H7 str. EDL933 960475 NP_287472.1 CDS narG NC_002655.2 1817023 1820766 D nitrate reductase 1 subunit alpha 1817023..1820766 Escherichia coli O157:H7 str. EDL933 960477 NP_287473.1 CDS narH NC_002655.2 1820763 1822301 D nitrate reductase 1 subunit beta 1820763..1822301 Escherichia coli O157:H7 str. EDL933 960478 NP_287474.1 CDS narJ NC_002655.2 1822298 1823008 D nitrate reductase 1, delta subunit, assembly function 1822298..1823008 Escherichia coli O157:H7 str. EDL933 960479 NP_287475.1 CDS narI NC_002655.2 1823008 1823685 D nitrate reductase 1, cytochrome b(NR), gamma subunit 1823008..1823685 Escherichia coli O157:H7 str. EDL933 960480 NP_287477.1 CDS purU NC_002655.2 1824763 1825605 R produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine; formyltetrahydrofolate deformylase complement(1824763..1825605) Escherichia coli O157:H7 str. EDL933 960484 NP_287478.1 CDS ychJ NC_002655.2 1825655 1826113 R hypothetical protein complement(1825655..1826113) Escherichia coli O157:H7 str. EDL933 960485 NP_287479.1 CDS ychK NC_002655.2 1826187 1827131 D hypothetical protein 1826187..1827131 Escherichia coli O157:H7 str. EDL933 960486 NP_287480.1 CDS hnr NC_002655.2 1827223 1828236 D response regulator of RpoS 1827223..1828236 Escherichia coli O157:H7 str. EDL933 960487 NP_287481.1 CDS galU NC_002655.2 1828438 1829346 D together with GalF subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose; UTP-glucose-1-phosphate uridylyltransferase 1828438..1829346 Escherichia coli O157:H7 str. EDL933 960488 NP_287482.1 CDS hns NC_002655.2 1829490 1829903 R global DNA-binding transcriptional dual regulator H-NS complement(1829490..1829903) Escherichia coli O157:H7 str. EDL933 960489 NP_287483.1 CDS tdk NC_002655.2 1830507 1831124 D catalyzes the formation of thymidine 5'-phosphate from thymidine; thymidine kinase 1830507..1831124 Escherichia coli O157:H7 str. EDL933 960490 NP_287484.1 CDS adhE NC_002655.2 1831425 1834100 R bifunctional acetaldehyde-CoA/alcohol dehydrogenase complement(1831425..1834100) Escherichia coli O157:H7 str. EDL933 960491 NP_287485.1 CDS ychE NC_002655.2 1834577 1835224 D hypothetical protein 1834577..1835224 Escherichia coli O157:H7 str. EDL933 960492 NP_287486.1 CDS oppA NC_002655.2 1835963 1837594 D oligopeptide transport; periplasmic binding protein 1835963..1837594 Escherichia coli O157:H7 str. EDL933 960493 NP_287487.1 CDS oppB NC_002655.2 1837680 1838600 D oligopeptide transporter permease 1837680..1838600 Escherichia coli O157:H7 str. EDL933 960494 NP_287488.1 CDS oppC NC_002655.2 1838615 1839523 D oligopeptide transport permease 1838615..1839523 Escherichia coli O157:H7 str. EDL933 960495 NP_287489.1 CDS oppD NC_002655.2 1839535 1840548 D oligopeptide ABC transporter ATP-binding protein 1839535..1840548 Escherichia coli O157:H7 str. EDL933 960496 NP_287490.1 CDS oppF NC_002655.2 1840545 1841549 D oligopeptide ABC transporter ATP-binding protein 1840545..1841549 Escherichia coli O157:H7 str. EDL933 960497 NP_287491.2 CDS Z2024 NC_002655.2 1841602 1841931 R highly acidic protein; the structure of the Haemophilus influenzae protein shows similarity to uracil DNA glycosylase inhibitor (Ugi); binds heat-unstable protein (HU-alpha) which is a histone-like protein; dsDNA-mimic protein complement(1841602..1841931) Escherichia coli O157:H7 str. EDL933 960498 NP_287492.1 CDS cls NC_002655.2 1841966 1843426 R catalyzes the transfer of a phosphatidyl group to phosphodidylglycerol to form cardiolipin (diphosphatidylglycerol); cardiolipin synthetase complement(1841966..1843426) Escherichia coli O157:H7 str. EDL933 960499 NP_287493.1 CDS kch NC_002655.2 1843798 1845051 R voltage-gated potassium channel complement(1843798..1845051) Escherichia coli O157:H7 str. EDL933 960501 NP_287494.2 CDS yciI NC_002655.2 1845352 1845648 R unknown function; YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the predicted reactions based on sequence and structure similarity; hypothetical protein complement(1845352..1845648) Escherichia coli O157:H7 str. EDL933 960503 NP_287495.1 CDS tonB NC_002655.2 1845873 1846592 D membrane spanning protein in TonB-ExbB-ExbD complex; transduces proton motive force of the cytoplasmic membrane to outer membrane transporters; involved in the transport of ron-siderophore complexes, vitamin B12 and colicins; transporter 1845873..1846592 Escherichia coli O157:H7 str. EDL933 960504 NP_287496.1 CDS yciA NC_002655.2 1846632 1847030 R YciA; hydrolase that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA and malonyl-CoA; member of the the acyl coenzyme A hydrolase of proteins; acyl-CoA thioester hydrolase complement(1846632..1847030) Escherichia coli O157:H7 str. EDL933 960505 NP_287497.1 CDS yciB NC_002655.2 1847135 1847674 R Involved in cell division; probably involved in intracellular septation; intracellular septation protein A complement(1847135..1847674) Escherichia coli O157:H7 str. EDL933 960506 NP_287498.1 CDS yciC NC_002655.2 1847704 1848447 R hypothetical protein complement(1847704..1848447) Escherichia coli O157:H7 str. EDL933 960507 NP_287499.1 CDS yciD NC_002655.2 1848804 1849442 D receptor for colicin S4; outer membrane protein W 1848804..1849442 Escherichia coli O157:H7 str. EDL933 960508 NP_287500.1 CDS intO NC_002655.2 1849488 1850618 R integrase for prophage CP-933O complement(1849488..1850618) Escherichia coli O157:H7 str. EDL933 960509 NP_287501.1 CDS exoO NC_002655.2 1850909 1853380 R exonuclease VIII complement(1850909..1853380) Escherichia coli O157:H7 str. EDL933 960510 NP_287502.1 CDS Z2038 NC_002655.2 1853473 1853673 R hypothetical protein complement(1853473..1853673) Escherichia coli O157:H7 str. EDL933 960511 NP_287503.1 CDS Z2039 NC_002655.2 1853661 1853954 R regulator of cell division encoded by prophage CP-933O complement(1853661..1853954) Escherichia coli O157:H7 str. EDL933 960512 NP_287504.1 CDS Z2040 NC_002655.2 1854323 1854556 D No significant matches; hypothetical protein 1854323..1854556 Escherichia coli O157:H7 str. EDL933 960513 NP_287505.1 CDS Z2041 NC_002655.2 1854534 1854941 R No significant matches; hypothetical protein complement(1854534..1854941) Escherichia coli O157:H7 str. EDL933 960514 NP_287506.1 CDS Z2042 NC_002655.2 1854964 1855182 R hypothetical protein complement(1854964..1855182) Escherichia coli O157:H7 str. EDL933 960515 NP_287507.1 CDS Z2043 NC_002655.2 1855255 1855554 R No significant matches; hypothetical protein complement(1855255..1855554) Escherichia coli O157:H7 str. EDL933 960516 NP_287508.1 CDS Z2045 NC_002655.2 1855818 1856225 R The transcriptional repressor of DicA (divison cell) has a hypothetical DNA binding domain. It represses the transcription of dicB and dicC, but its specific role in cellular replication and mode of action are still unknown.; transcriptional repressor DicA complement(1855818..1856225) Escherichia coli O157:H7 str. EDL933 960517 NP_287509.1 CDS Z2046 NC_002655.2 1856302 1856529 D DNA-binding transcriptional regulator DicC 1856302..1856529 Escherichia coli O157:H7 str. EDL933 960518 NP_287510.1 CDS Z2047 NC_002655.2 1856513 1857064 D hypothetical protein 1856513..1857064 Escherichia coli O157:H7 str. EDL933 960519 NP_287511.1 CDS Z2048 NC_002655.2 1857036 1858076 D hypothetical protein 1857036..1858076 Escherichia coli O157:H7 str. EDL933 960520 NP_287512.1 CDS Z2049 NC_002655.2 1857865 1858530 D hypothetical protein 1857865..1858530 Escherichia coli O157:H7 str. EDL933 960521 NP_287513.1 CDS Z2051 NC_002655.2 1858717 1859298 D hypothetical protein 1858717..1859298 Escherichia coli O157:H7 str. EDL933 960522 NP_287514.1 CDS Z2052 NC_002655.2 1859890 1859997 D No significant matches; hypothetical protein 1859890..1859997 Escherichia coli O157:H7 str. EDL933 960523 NP_287515.1 CDS Z2053 NC_002655.2 1860158 1860916 D intestinal colonization factor encoded by prophage CP-933O 1860158..1860916 Escherichia coli O157:H7 str. EDL933 960524 NP_287516.1 CDS Z2054 NC_002655.2 1861195 1861407 D killer protein encoded by prophage CP-933O; paralogous proteins disrupt host membranes when produced in excess 1861195..1861407 Escherichia coli O157:H7 str. EDL933 960525 NP_287517.1 CDS Z2055 NC_002655.2 1861628 1861885 D hypothetical protein 1861628..1861885 Escherichia coli O157:H7 str. EDL933 960526 NP_287518.1 CDS Z2056 NC_002655.2 1862299 1863282 D hypothetical protein 1862299..1863282 Escherichia coli O157:H7 str. EDL933 960527 NP_287519.1 CDS Z2057 NC_002655.2 1863295 1863654 D endonuclease of prophage CP-933O 1863295..1863654 Escherichia coli O157:H7 str. EDL933 960528 NP_287520.1 CDS Z2058 NC_002655.2 1863651 1864193 D No significant matches; hypothetical protein 1863651..1864193 Escherichia coli O157:H7 str. EDL933 960529 NP_287521.1 CDS Z2059 NC_002655.2 1864312 1864632 D hypothetical protein 1864312..1864632 Escherichia coli O157:H7 str. EDL933 960530 NP_287522.1 CDS Z2060 NC_002655.2 1864783 1865841 D DNA adenine methyltransferase encoded by prophage CP-933O 1864783..1865841 Escherichia coli O157:H7 str. EDL933 960531 NP_287524.1 CDS Z2065 NC_002655.2 1866638 1867588 D phage protein YjhS encoded within prophage CP-933O 1866638..1867588 Escherichia coli O157:H7 str. EDL933 960535 NP_287525.1 CDS Z2066 NC_002655.2 1867576 1868448 D hypothetical protein 1867576..1868448 Escherichia coli O157:H7 str. EDL933 960536 NP_287526.1 CDS Z2068 NC_002655.2 1868303 1868491 D No significant matches; hypothetical protein 1868303..1868491 Escherichia coli O157:H7 str. EDL933 960537 NP_287527.1 CDS Z2069 NC_002655.2 1868940 1869146 D holin protein of prophage CP-933O 1868940..1869146 Escherichia coli O157:H7 str. EDL933 960538 NP_287528.1 CDS Z2070 NC_002655.2 1869148 1869495 D hypothetical protein 1869148..1869495 Escherichia coli O157:H7 str. EDL933 960539 NP_287529.1 CDS Z2071 NC_002655.2 1869546 1869776 D endolysin of prophage CP933-O; partial 1869546..1869776 Escherichia coli O157:H7 str. EDL933 960540 NP_287530.1 CDS Z2072 NC_002655.2 1870229 1870576 D IS encoded proteinen coded by prophage CP-933O 1870229..1870576 Escherichia coli O157:H7 str. EDL933 960541 NP_287531.1 CDS Z2073 NC_002655.2 1871077 1871724 R transposase within CP-933O complement(1871077..1871724) Escherichia coli O157:H7 str. EDL933 960542 NP_287532.1 CDS Z2074 NC_002655.2 1871964 1872290 R IS encoded protein within CP-933O complement(1871964..1872290) Escherichia coli O157:H7 str. EDL933 960543 NP_287533.1 CDS Z2075 NC_002655.2 1872625 1873119 D hypothetical protein 1872625..1873119 Escherichia coli O157:H7 str. EDL933 960544 NP_287534.1 CDS Z2076 NC_002655.2 1873441 1873593 D No significant matches; hypothetical protein 1873441..1873593 Escherichia coli O157:H7 str. EDL933 960545 NP_287535.1 CDS Z2077 NC_002655.2 1873867 1874514 D hypothetical protein 1873867..1874514 Escherichia coli O157:H7 str. EDL933 960546 NP_287536.1 CDS Z2078 NC_002655.2 1874668 1875090 D transposase within CP-933O 1874668..1875090 Escherichia coli O157:H7 str. EDL933 960547 NP_287537.1 CDS Z2079 NC_002655.2 1875212 1875622 R IS encoded protein within CP-933O complement(1875212..1875622) Escherichia coli O157:H7 str. EDL933 960548 NP_287538.1 CDS Z2080 NC_002655.2 1875922 1876614 R IS encoded protein within CP-933O complement(1875922..1876614) Escherichia coli O157:H7 str. EDL933 960549 NP_287539.1 CDS Z2081 NC_002655.2 1876695 1877042 R IS encoded protein within CP-933O complement(1876695..1877042) Escherichia coli O157:H7 str. EDL933 960550 NP_287540.1 CDS Z2082 NC_002655.2 1877451 1878332 D transposase within CP-933O; partial 1877451..1878332 Escherichia coli O157:H7 str. EDL933 960551 NP_287541.1 CDS Z2083 NC_002655.2 1878382 1878717 R hypothetical protein complement(1878382..1878717) Escherichia coli O157:H7 str. EDL933 960552 NP_287542.1 CDS Z2084 NC_002655.2 1878802 1879269 R integrase within CP-933O; partial complement(1878802..1879269) Escherichia coli O157:H7 str. EDL933 960553 NP_287543.1 CDS Z2085 NC_002655.2 1879335 1880579 R exonuclease VIII complement(1879335..1880579) Escherichia coli O157:H7 str. EDL933 960554 NP_287544.1 CDS Z2086 NC_002655.2 1880857 1881150 R division inhibition protein DicB within CP-933O complement(1880857..1881150) Escherichia coli O157:H7 str. EDL933 960555 NP_287545.1 CDS Z2087 NC_002655.2 1881371 1881436 R No significant matches; hypothetical protein complement(1881371..1881436) Escherichia coli O157:H7 str. EDL933 960556 NP_287546.1 CDS Z2088 NC_002655.2 1881820 1882470 R No significant matches; hypothetical protein complement(1881820..1882470) Escherichia coli O157:H7 str. EDL933 960557 NP_287547.1 CDS Z2089 NC_002655.2 1882470 1882703 R hypothetical protein complement(1882470..1882703) Escherichia coli O157:H7 str. EDL933 960558 NP_287548.1 CDS Z2090 NC_002655.2 1882915 1883553 R repressor protein encoded within prophage CP-933O complement(1882915..1883553) Escherichia coli O157:H7 str. EDL933 960559 NP_287549.1 CDS Z2091 NC_002655.2 1883633 1883887 D hypothetical protein 1883633..1883887 Escherichia coli O157:H7 str. EDL933 960560 NP_287550.1 CDS Z2092 NC_002655.2 1883871 1884296 D hypothetical protein 1883871..1884296 Escherichia coli O157:H7 str. EDL933 960561 NP_287551.1 CDS Z2093 NC_002655.2 1884365 1885408 D hypothetical protein 1884365..1885408 Escherichia coli O157:H7 str. EDL933 960562 NP_287552.1 CDS Z2094 NC_002655.2 1885200 1885862 D hypothetical protein 1885200..1885862 Escherichia coli O157:H7 str. EDL933 960563 NP_287553.1 CDS Z2095 NC_002655.2 1885896 1886153 D hypothetical protein 1885896..1886153 Escherichia coli O157:H7 str. EDL933 960564 NP_287554.1 CDS Z2096 NC_002655.2 1886131 1886613 D hypothetical protein 1886131..1886613 Escherichia coli O157:H7 str. EDL933 960565 NP_287555.1 CDS Z2097 NC_002655.2 1887144 1887455 D No significant matches; hypothetical protein 1887144..1887455 Escherichia coli O157:H7 str. EDL933 960566 NP_287556.1 CDS Z2098 NC_002655.2 1887803 1888360 D hypothetical protein 1887803..1888360 Escherichia coli O157:H7 str. EDL933 960567 NP_287557.1 CDS Z2099 NC_002655.2 1888927 1889271 D hypothetical protein 1888927..1889271 Escherichia coli O157:H7 str. EDL933 960568 NP_287558.1 CDS Z2100 NC_002655.2 1889668 1890717 D hypothetical protein 1889668..1890717 Escherichia coli O157:H7 str. EDL933 960569 NP_287559.1 CDS Z2101 NC_002655.2 1890730 1891035 D endonuclease encoded within prophage CP-933O 1890730..1891035 Escherichia coli O157:H7 str. EDL933 960570 NP_287560.1 CDS Z2102 NC_002655.2 1891086 1891652 D No significant matches; hypothetical protein 1891086..1891652 Escherichia coli O157:H7 str. EDL933 960571 NP_287561.1 CDS Z2103 NC_002655.2 1891790 1892074 D hypothetical protein 1891790..1892074 Escherichia coli O157:H7 str. EDL933 960572 NP_287562.1 CDS Z2104 NC_002655.2 1892210 1892923 D AraC family transcriptional regulator 1892210..1892923 Escherichia coli O157:H7 str. EDL933 960573 NP_287563.1 CDS Z2105 NC_002655.2 1893311 1893541 D No significant matches; hypothetical protein 1893311..1893541 Escherichia coli O157:H7 str. EDL933 960574 NP_287564.1 CDS Z2106 NC_002655.2 1893498 1893806 D No significant matches; hypothetical protein 1893498..1893806 Escherichia coli O157:H7 str. EDL933 960575 NP_287565.1 CDS Z2107 NC_002655.2 1893803 1893970 D No significant matches; hypothetical protein 1893803..1893970 Escherichia coli O157:H7 str. EDL933 960576 NP_287566.1 CDS Z2108 NC_002655.2 1894381 1895331 D phage protein YjhS encoded within prophage CP-933O 1894381..1895331 Escherichia coli O157:H7 str. EDL933 960577 NP_287567.1 CDS Z2109 NC_002655.2 1895319 1896233 D phage protein YjhS encoded within prophage CP-933O 1895319..1896233 Escherichia coli O157:H7 str. EDL933 960578 NP_287568.1 CDS Z2110 NC_002655.2 1896409 1896735 D transposase encoded within prophage CP-933O 1896409..1896735 Escherichia coli O157:H7 str. EDL933 960580 NP_287569.1 CDS Z2111 NC_002655.2 1896975 1897622 D transposase encoded within prophage CP-933O 1896975..1897622 Escherichia coli O157:H7 str. EDL933 960581 NP_287570.1 CDS Z2112 NC_002655.2 1897625 1898422 R ClpP-like protease encoded within prophage CP-933O complement(1897625..1898422) Escherichia coli O157:H7 str. EDL933 960582 NP_287571.1 CDS Z2113 NC_002655.2 1898650 1899156 R hypothetical protein complement(1898650..1899156) Escherichia coli O157:H7 str. EDL933 960583 NP_287572.1 CDS Z2114 NC_002655.2 1899500 1900006 R No significant matches; hypothetical protein complement(1899500..1900006) Escherichia coli O157:H7 str. EDL933 960584 NP_287573.1 CDS Z2115 NC_002655.2 1900215 1900775 R No significant matches; hypothetical protein complement(1900215..1900775) Escherichia coli O157:H7 str. EDL933 960585 NP_287574.1 CDS Z2116 NC_002655.2 1900720 1902228 R hypothetical protein complement(1900720..1902228) Escherichia coli O157:H7 str. EDL933 960586 NP_287575.1 CDS Z2117 NC_002655.2 1902336 1902812 R No significant matches; hypothetical protein complement(1902336..1902812) Escherichia coli O157:H7 str. EDL933 960587 NP_287576.1 CDS Z2118 NC_002655.2 1903267 1903734 R endopeptidase Rz of prophage CP-933O complement(1903267..1903734) Escherichia coli O157:H7 str. EDL933 960588 NP_287577.1 CDS Z2119 NC_002655.2 1903736 1903888 R No significant matches; hypothetical protein complement(1903736..1903888) Escherichia coli O157:H7 str. EDL933 960589 NP_287578.1 CDS Z2120 NC_002655.2 1904070 1904603 R endolysin of prophage CP-933O complement(1904070..1904603) Escherichia coli O157:H7 str. EDL933 960590 NP_287579.1 CDS Z2121 NC_002655.2 1904721 1905035 D No significant matches; hypothetical protein 1904721..1905035 Escherichia coli O157:H7 str. EDL933 960591 NP_287580.1 CDS Z2122 NC_002655.2 1905291 1905497 R holin protein of prophage CP-933O complement(1905291..1905497) Escherichia coli O157:H7 str. EDL933 960592 NP_287581.1 CDS Z2123 NC_002655.2 1905505 1905666 D No significant matches; hypothetical protein 1905505..1905666 Escherichia coli O157:H7 str. EDL933 960593 NP_287582.1 CDS Z2124 NC_002655.2 1906248 1906523 D No significant matches; hypothetical protein 1906248..1906523 Escherichia coli O157:H7 str. EDL933 960594 NP_287583.1 CDS Z2127 NC_002655.2 1906763 1907323 D prophage CP-933O IS protein 1906763..1907323 Escherichia coli O157:H7 str. EDL933 960595 NP_287584.1 CDS Z2130 NC_002655.2 1907373 1908911 D prophage CP-933O IS protein 1907373..1908911 Escherichia coli O157:H7 str. EDL933 960596 NP_287585.1 CDS Z2131 NC_002655.2 1909139 1911103 D terminase large subunit of prophage CP-933O 1909139..1911103 Escherichia coli O157:H7 str. EDL933 960597 NP_287586.1 CDS Z2132 NC_002655.2 1911153 1911293 D head completion protein of prophage CP-933O 1911153..1911293 Escherichia coli O157:H7 str. EDL933 960598 NP_287587.1 CDS Z2133 NC_002655.2 1911290 1912882 D capsid assembly protein of prophage CP-933O 1911290..1912882 Escherichia coli O157:H7 str. EDL933 960599 NP_287588.1 CDS Z2134 NC_002655.2 1912872 1914377 D head-tail preconnector protein of prophage CP-933O 1912872..1914377 Escherichia coli O157:H7 str. EDL933 960600 NP_287589.1 CDS Z2135 NC_002655.2 1914414 1914761 D capsid protein small subunit of prophage CP-933O 1914414..1914761 Escherichia coli O157:H7 str. EDL933 960601 NP_287590.1 CDS Z2136 NC_002655.2 1914819 1915085 D major capsid protein of prophage CP-933O 1914819..1915085 Escherichia coli O157:H7 str. EDL933 960602 NP_287591.1 CDS Z2137 NC_002655.2 1915178 1915807 D tail component of prophage CP-933O 1915178..1915807 Escherichia coli O157:H7 str. EDL933 960603 NP_287592.1 CDS Z2138 NC_002655.2 1915749 1916252 D tail component of prophage CP-933O 1915749..1916252 Escherichia coli O157:H7 str. EDL933 960604 NP_287593.1 CDS Z2139 NC_002655.2 1916279 1916692 D tail component of prophage CP-933O 1916279..1916692 Escherichia coli O157:H7 str. EDL933 960605 NP_287594.1 CDS Z2140 NC_002655.2 1916673 1919252 D tail component of prophage CP-933O 1916673..1919252 Escherichia coli O157:H7 str. EDL933 960606 NP_287595.1 CDS Z2141 NC_002655.2 1919249 1919578 D tail component of prophage CP-933O 1919249..1919578 Escherichia coli O157:H7 str. EDL933 960607 NP_287596.1 CDS Z2142 NC_002655.2 1919578 1920276 D tail component of prophage CP-933O 1919578..1920276 Escherichia coli O157:H7 str. EDL933 960608 NP_287597.1 CDS Z2143 NC_002655.2 1920149 1921030 D tail component of prophage CP-933O 1920149..1921030 Escherichia coli O157:H7 str. EDL933 960609 NP_287598.1 CDS Z2144 NC_002655.2 1920928 1921605 D tail component of prophage CP-933O 1920928..1921605 Escherichia coli O157:H7 str. EDL933 960610 NP_287599.1 CDS Z2145 NC_002655.2 1921846 1925322 D tail component of prophage CP-933O 1921846..1925322 Escherichia coli O157:H7 str. EDL933 960611 NP_287600.1 CDS Z2146 NC_002655.2 1925390 1925989 D outer membrane protein Lom of prophage CP-933O 1925390..1925989 Escherichia coli O157:H7 str. EDL933 960612 NP_287601.1 CDS Z2147 NC_002655.2 1926048 1927367 D tail fiber protein of prophage CP-933O 1926048..1927367 Escherichia coli O157:H7 str. EDL933 960613 NP_287602.1 CDS Z2148 NC_002655.2 1927369 1927638 D hypothetical protein 1927369..1927638 Escherichia coli O157:H7 str. EDL933 960614 NP_287603.1 CDS Z2149 NC_002655.2 1927752 1928327 D hypothetical protein 1927752..1928327 Escherichia coli O157:H7 str. EDL933 960615 NP_287604.1 CDS Z2150 NC_002655.2 1928400 1929029 D hypothetical protein 1928400..1929029 Escherichia coli O157:H7 str. EDL933 960616 NP_287605.1 CDS Z2151 NC_002655.2 1929111 1929752 D hypothetical protein 1929111..1929752 Escherichia coli O157:H7 str. EDL933 960617 NP_287606.1 CDS Z2152 NC_002655.2 1929903 1930250 R hypothetical protein complement(1929903..1930250) Escherichia coli O157:H7 str. EDL933 960618 NP_287607.1 CDS ydfJ NC_002655.2 1930289 1931572 D transporter 1930289..1931572 Escherichia coli O157:H7 str. EDL933 960619 NP_287608.1 CDS ydfI NC_002655.2 1931661 1933121 D oxidoreductase 1931661..1933121 Escherichia coli O157:H7 str. EDL933 960620 NP_287609.1 CDS Z2156 NC_002655.2 1933157 1933360 R hypothetical protein complement(1933157..1933360) Escherichia coli O157:H7 str. EDL933 960621 NP_287610.1 CDS ydfH NC_002655.2 1933537 1934223 R hypothetical protein complement(1933537..1934223) Escherichia coli O157:H7 str. EDL933 960622 NP_287611.1 CDS ydfG NC_002655.2 1934312 1935058 R NADP(+)-dependent; catalyzes the formation of 2-aminomalonate-semialdehyde from L-serine; can also use 3-hydroxybutyrate, 3-hydroxy-isobutyrate, D-threonine, L-allo-threonine,D-serine; 3-hydroxy acid dehydrogenase complement(1934312..1935058) Escherichia coli O157:H7 str. EDL933 960623 NP_287612.1 CDS dcp NC_002655.2 1935195 1937240 D dipeptidyl carboxypeptidase II 1935195..1937240 Escherichia coli O157:H7 str. EDL933 960624 NP_287613.1 CDS ydeJ NC_002655.2 1937285 1937803 R competence damage-inducible protein A complement(1937285..1937803) Escherichia coli O157:H7 str. EDL933 960625 NP_287614.1 CDS ydeI NC_002655.2 1938079 1938471 D hypothetical protein 1938079..1938471 Escherichia coli O157:H7 str. EDL933 960626 NP_287615.1 CDS ydeH NC_002655.2 1938726 1939616 D hypothetical protein 1938726..1939616 Escherichia coli O157:H7 str. EDL933 960627 NP_287616.1 CDS ftrA NC_002655.2 1940038 1941021 R upregulated by FixLJ/FixK under oxygen limitation; involved in regulation of genes involved in carbon and amino acid metabolism; transcriptional activator FtrA complement(1940038..1941021) Escherichia coli O157:H7 str. EDL933 960628 NP_287617.1 CDS Z2165 NC_002655.2 1941104 1941499 D No significant matches; hypothetical protein 1941104..1941499 Escherichia coli O157:H7 str. EDL933 960629 NP_287618.1 CDS ydeF NC_002655.2 1941540 1942727 R YdeF; uncharacterized member of the major facilitator superfamily (MFS) of transporters; MFS-type transporter YdeE complement(1941540..1942727) Escherichia coli O157:H7 str. EDL933 960630 NP_287619.1 CDS ydeD NC_002655.2 1943021 1943821 D O-acetylserine/cysteine export protein 1943021..1943821 Escherichia coli O157:H7 str. EDL933 960631 NP_287620.1 CDS marB NC_002655.2 1943852 1944070 R hypothetical protein complement(1943852..1944070) Escherichia coli O157:H7 str. EDL933 960632 NP_287621.2 CDS marA NC_002655.2 1944102 1944485 R transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype; also activates sodA, zwf and micF; DNA-binding transcriptional activator MarA complement(1944102..1944485) Escherichia coli O157:H7 str. EDL933 960633 NP_287622.2 CDS marR NC_002655.2 1944505 1944939 R Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes; MarR family transcriptional regulator complement(1944505..1944939) Escherichia coli O157:H7 str. EDL933 960634 NP_287623.1 CDS ydeB NC_002655.2 1945151 1945816 D protein involved in resistance to different drugs (tetracycline, chloramphenicol, beta-lactams, and quinolones); part of the multiple antibiotic resistance (mar) locus, which is composed by the genes marC and marRAB; unknown function; multiple drug resistance protein MarC 1945151..1945816 Escherichia coli O157:H7 str. EDL933 960635 NP_287624.1 CDS ydeA NC_002655.2 1945841 1947031 R sugar efflux transporter complement(1945841..1947031) Escherichia coli O157:H7 str. EDL933 960636 NP_287625.1 CDS Z2175 NC_002655.2 1947183 1947452 R hypothetical protein complement(1947183..1947452) Escherichia coli O157:H7 str. EDL933 960637 NP_287626.1 CDS Z2176 NC_002655.2 1947510 1948298 R hypothetical protein complement(1947510..1948298) Escherichia coli O157:H7 str. EDL933 960638 NP_287627.1 CDS yneJ NC_002655.2 1948376 1949257 R LysR family transcriptional regulator complement(1948376..1949257) Escherichia coli O157:H7 str. EDL933 960639 NP_287628.1 CDS yneI NC_002655.2 1949334 1950746 D in Escherichia coli this enzyme appears to be an NAD+/NADP+-dependent succinate semialdehyde dehydrogenase; succinate semialdehyde dehydrogenase 1949334..1950746 Escherichia coli O157:H7 str. EDL933 960640 NP_287629.1 CDS yneH NC_002655.2 1950810 1951736 D catalyzes the formation of glutamate from glutamine; glutaminase 1950810..1951736 Escherichia coli O157:H7 str. EDL933 960641 NP_287630.1 CDS Z2180 NC_002655.2 1951736 1952095 D hypothetical protein 1951736..1952095 Escherichia coli O157:H7 str. EDL933 960642 NP_287631.1 CDS Z2181 NC_002655.2 1952264 1952428 D No significant matches; hypothetical protein 1952264..1952428 Escherichia coli O157:H7 str. EDL933 960643 NP_287632.1 CDS Z2182 NC_002655.2 1952706 1953653 D hypothetical protein 1952706..1953653 Escherichia coli O157:H7 str. EDL933 960644 NP_287633.2 CDS uxaB NC_002655.2 1953880 1955331 D catalyzes the formation of D-tagaturonate from D-altronate; altronate oxidoreductase 1953880..1955331 Escherichia coli O157:H7 str. EDL933 960645 NP_287634.1 CDS Z2185 NC_002655.2 1955477 1956442 D hypothetical protein 1955477..1956442 Escherichia coli O157:H7 str. EDL933 960646 NP_287635.1 CDS Z2186 NC_002655.2 1956446 1957204 R catalyzes the formation of (E)-3-(methoxycarbonyl)pent-2-enedioate and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and trans-aconitate; trans-aconitate 2-methyltransferase complement(1956446..1957204) Escherichia coli O157:H7 str. EDL933 960647 NP_287636.1 CDS Z2187 NC_002655.2 1957261 1957551 R autoinducer-2 (AI-2) modifying protein LsrG complement(1957261..1957551) Escherichia coli O157:H7 str. EDL933 960648 NP_287637.1 CDS yneB NC_002655.2 1957575 1958450 R aldolase complement(1957575..1958450) Escherichia coli O157:H7 str. EDL933 960649 NP_287638.1 CDS Z2189 NC_002655.2 1958477 1959499 R LACI-type transcriptional regulator complement(1958477..1959499) Escherichia coli O157:H7 str. EDL933 960650 NP_287639.1 CDS ydeZ NC_002655.2 1959511 1960503 R transport system permease complement(1959511..1960503) Escherichia coli O157:H7 str. EDL933 960651 NP_287640.1 CDS ydeY NC_002655.2 1960503 1961531 R transport system permease complement(1960503..1961531) Escherichia coli O157:H7 str. EDL933 960652 NP_287641.1 CDS Z2192 NC_002655.2 1961525 1963060 R ABC transporter ATP-binding protein complement(1961525..1963060) Escherichia coli O157:H7 str. EDL933 960653 NP_287642.1 CDS ydeW NC_002655.2 1963309 1964262 D SorC family transcriptional regulator 1963309..1964262 Escherichia coli O157:H7 str. EDL933 960654 NP_287643.1 CDS ydeV NC_002655.2 1964341 1965933 D autoinducer-2 (AI-2) kinase 1964341..1965933 Escherichia coli O157:H7 str. EDL933 960655 NP_287644.1 CDS ydeK NC_002655.2 1966464 1970495 D lipoprotein 1966464..1970495 Escherichia coli O157:H7 str. EDL933 960656 NP_287645.1 CDS Z2196 NC_002655.2 1970492 1971892 D ABC transporter ATP-binding protein 1970492..1971892 Escherichia coli O157:H7 str. EDL933 960657 NP_287646.1 CDS hipA NC_002655.2 1972050 1973072 D DNA-binding regulator 1972050..1973072 Escherichia coli O157:H7 str. EDL933 960658 NP_287647.1 CDS Z2199 NC_002655.2 1973409 1973612 D hypothetical protein 1973409..1973612 Escherichia coli O157:H7 str. EDL933 960659 NP_287648.1 CDS Z2200 NC_002655.2 1974046 1974609 D major fimbrial subunit 1974046..1974609 Escherichia coli O157:H7 str. EDL933 960660 NP_287649.1 CDS Z2201 NC_002655.2 1974961 1975680 D fimbrial chaperone protein 1974961..1975680 Escherichia coli O157:H7 str. EDL933 960661 NP_287650.1 CDS Z2203 NC_002655.2 1975722 1978373 D fimbrial usher protein 1975722..1978373 Escherichia coli O157:H7 str. EDL933 960662 NP_287651.1 CDS Z2204 NC_002655.2 1978387 1978917 D fimbrial-like protein 1978387..1978917 Escherichia coli O157:H7 str. EDL933 960663 NP_287652.1 CDS Z2205 NC_002655.2 1978930 1979433 D fimbrial-like protein 1978930..1979433 Escherichia coli O157:H7 str. EDL933 960664 NP_287653.1 CDS Z2206 NC_002655.2 1979493 1980407 D adhesin FimH 1979493..1980407 Escherichia coli O157:H7 str. EDL933 960665 NP_287654.1 CDS Z2207 NC_002655.2 1980741 1983020 D in Escherichia coli it may be involved in repression of type III secretion system (TTSS) genes of the host cell; involved with increased resistance to low pH; member of the prokaryotic molybdopterin-containing oxidoreductase; oxidoreductase 1980741..1983020 Escherichia coli O157:H7 str. EDL933 960666 NP_287655.1 CDS Z2208 NC_002655.2 1983268 1983465 D hypothetical protein 1983268..1983465 Escherichia coli O157:H7 str. EDL933 960667 NP_287656.1 CDS Z2209 NC_002655.2 1983539 1984300 D regulates the cellular response to acid resistance; transcriptional regulator YdeO 1983539..1984300 Escherichia coli O157:H7 str. EDL933 960668 NP_287657.1 CDS Z2210 NC_002655.2 1984671 1986386 D sulfatase 1984671..1986386 Escherichia coli O157:H7 str. EDL933 960669 NP_287658.1 CDS Z2211 NC_002655.2 1986423 1987595 D hypothetical protein 1986423..1987595 Escherichia coli O157:H7 str. EDL933 960670 NP_287659.1 CDS yddA NC_002655.2 1987886 1989571 D ABC transporter ATP-binding protein 1987886..1989571 Escherichia coli O157:H7 str. EDL933 960672 NP_287660.1 CDS yddB NC_002655.2 1989609 1991981 D hypothetical protein 1989609..1991981 Escherichia coli O157:H7 str. EDL933 960673 NP_287661.1 CDS pqqL NC_002655.2 1992026 1994821 D peptidase 1992026..1994821 Escherichia coli O157:H7 str. EDL933 960674 NP_287662.1 CDS gadB NC_002655.2 1995182 1996582 D glutamate decarboxylase 1995182..1996582 Escherichia coli O157:H7 str. EDL933 960675 NP_287663.1 CDS xasA NC_002655.2 1996738 1998273 D acid sensitivity protein 1996738..1998273 Escherichia coli O157:H7 str. EDL933 960676 NP_287664.1 CDS Z2217 NC_002655.2 1998404 1999723 D hypothetical protein 1998404..1999723 Escherichia coli O157:H7 str. EDL933 960677 NP_287665.1 CDS Z2219 NC_002655.2 2000100 2001482 D hypothetical protein 2000100..2001482 Escherichia coli O157:H7 str. EDL933 960678 NP_287666.1 CDS Z2221m NC_002655.2 2001483 2003896 D heme-regulated phosphodiesterase with phosphodiesterase activity with cAMP but not with cGMP, bis(p-nitrophenyl) phosphate or p-nitrophenyl phosphate; cAMP phosphodiesterase join(2001483..2002721,2002721..2003896) Escherichia coli O157:H7 str. EDL933 959622 NP_287667.1 CDS Z2222 NC_002655.2 2004154 2004735 D catalyzes the hydrolysis of D-alanyl-D-alanine dipeptide: Zn dependent; involved in peptidoglycan synthesis; D-alanyl-D-alanine dipeptidase 2004154..2004735 Escherichia coli O157:H7 str. EDL933 960679 NP_287668.1 CDS Z2223 NC_002655.2 2004749 2006299 D hemin-binding lipoprotein 2004749..2006299 Escherichia coli O157:H7 str. EDL933 960680 NP_287669.1 CDS Z2224 NC_002655.2 2006342 2007322 D transport system permease 2006342..2007322 Escherichia coli O157:H7 str. EDL933 960682 NP_287670.1 CDS Z2225 NC_002655.2 2007319 2008215 D ATP-dependent peptide transporter membrane subunit 2007319..2008215 Escherichia coli O157:H7 str. EDL933 960683 NP_287671.1 CDS Z2226 NC_002655.2 2008212 2009198 D ABC transporter ATP-binding protein 2008212..2009198 Escherichia coli O157:H7 str. EDL933 960684 NP_287672.1 CDS Z2227 NC_002655.2 2009191 2010117 D ABC transporter ATP-binding protein 2009191..2010117 Escherichia coli O157:H7 str. EDL933 960685 NP_287673.1 CDS osmC NC_002655.2 2010173 2010604 R osmotically inducible protein complement(2010173..2010604) Escherichia coli O157:H7 str. EDL933 960686 NP_287674.2 CDS Z2229 NC_002655.2 2010950 2011165 D biofilm-dependent modulation protein 2010950..2011165 Escherichia coli O157:H7 str. EDL933 960687 NP_287675.1 CDS rpsV NC_002655.2 2011267 2011404 D protein D; stationary-phase-induced ribosome-associated; in Escherichia coli this protein becomes associated with the ribosome; expression increases during stationary phase; 30S ribosomal subunit S22 2011267..2011404 Escherichia coli O157:H7 str. EDL933 960688 NP_287676.2 CDS sfcA NC_002655.2 2011561 2013258 D malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate; malate dehydrogenase 2011561..2013258 Escherichia coli O157:H7 str. EDL933 960690 NP_287677.2 CDS adhP NC_002655.2 2013392 2014402 D similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs; alcohol dehydrogenase 2013392..2014402 Escherichia coli O157:H7 str. EDL933 960692 NP_287678.1 CDS yddM NC_002655.2 2014470 2014832 D hypothetical protein 2014470..2014832 Escherichia coli O157:H7 str. EDL933 960694 NP_287679.1 CDS fdnI NC_002655.2 2015060 2015713 R nitrate-inducible, cytochrome b556(fdn) component of formate dehydrogenase; formate dehydrogenase-N subunit gamma complement(2015060..2015713) Escherichia coli O157:H7 str. EDL933 960699 NP_287680.1 CDS fdnH NC_002655.2 2015706 2016590 R formate dehydrogenase-N, nitrate-inducible, iron-sulfur beta subunit complement(2015706..2016590) Escherichia coli O157:H7 str. EDL933 960701 NP_287681.1 CDS fdnG NC_002655.2 2016603 2019650 R formate dehydrogenase-N, nitrate-inducible, alpha subunit complement(2016603..2019650) Escherichia coli O157:H7 str. EDL933 960702 NP_287682.1 CDS yddG NC_002655.2 2019882 2020763 D hypothetical protein 2019882..2020763 Escherichia coli O157:H7 str. EDL933 960703 NP_287683.1 CDS Z2239 NC_002655.2 2021022 2022122 D porin 2021022..2022122 Escherichia coli O157:H7 str. EDL933 960704 NP_287684.1 CDS Z2240 NC_002655.2 2022291 2022794 D hypothetical protein 2022291..2022794 Escherichia coli O157:H7 str. EDL933 960705 NP_287685.1 CDS Z2241 NC_002655.2 2022917 2023549 D hypothetical protein 2022917..2023549 Escherichia coli O157:H7 str. EDL933 960706 NP_287686.1 CDS Z2242 NC_002655.2 2023612 2024871 D hypothetical protein 2023612..2024871 Escherichia coli O157:H7 str. EDL933 960707 NP_287687.1 CDS narU NC_002655.2 2025177 2026565 D nitrite extrusion protein 2 2025177..2026565 Escherichia coli O157:H7 str. EDL933 960708 NP_287688.1 CDS narZ NC_002655.2 2026647 2030387 D cryptic nitrate reductase 2 subunit alpha 2026647..2030387 Escherichia coli O157:H7 str. EDL933 960709 NP_287689.1 CDS narY NC_002655.2 2030384 2031928 D cryptic nitrate reductase 2 subunit beta 2030384..2031928 Escherichia coli O157:H7 str. EDL933 960710 NP_287690.1 CDS narW NC_002655.2 2031928 2032623 D cryptic nitrate reductase 2 subunit delta 2031928..2032623 Escherichia coli O157:H7 str. EDL933 960713 NP_287691.1 CDS narV NC_002655.2 2032620 2033300 D cryptic nitrate reductase 2 subunit gamma 2032620..2033300 Escherichia coli O157:H7 str. EDL933 960731 NP_287692.1 CDS yddE NC_002655.2 2033379 2034272 D hypothetical protein 2033379..2034272 Escherichia coli O157:H7 str. EDL933 960735 NP_287693.1 CDS Z2249 NC_002655.2 2034368 2034523 R hypothetical protein complement(2034368..2034523) Escherichia coli O157:H7 str. EDL933 960739 NP_287694.1 CDS Z2250 NC_002655.2 2034478 2035212 R N-hydroxyarylamine O-acetyltransferase complement(2034478..2035212) Escherichia coli O157:H7 str. EDL933 960742 NP_287695.1 CDS Z2251 NC_002655.2 2035511 2035954 D hypothetical protein 2035511..2035954 Escherichia coli O157:H7 str. EDL933 960744 NP_287696.1 CDS ydcE NC_002655.2 2035958 2036224 R 4-OT; member of subfamily 5; forms a dimer; the function in the Escherichia coli cell is unknown; 4-oxalocrotonate tautomerase complement(2035958..2036224) Escherichia coli O157:H7 str. EDL933 960745 NP_287697.1 CDS Z2253 NC_002655.2 2036554 2037165 R H repeat-containing Rhs element protein complement(2036554..2037165) Escherichia coli O157:H7 str. EDL933 960765 NP_287698.1 CDS Z2254 NC_002655.2 2037265 2037444 R H repeat-containing Rhs element protein complement(2037265..2037444) Escherichia coli O157:H7 str. EDL933 960766 NP_287699.1 CDS Z2255 NC_002655.2 2037736 2037885 R No significant matches; Rhs element protein complement(2037736..2037885) Escherichia coli O157:H7 str. EDL933 960768 NP_287700.1 CDS Z2256 NC_002655.2 2037952 2038161 R Rhs element protein complement(2037952..2038161) Escherichia coli O157:H7 str. EDL933 960769 NP_287701.1 CDS Z2257 NC_002655.2 2038358 2040328 R Rhs element protein complement(2038358..2040328) Escherichia coli O157:H7 str. EDL933 960770 NP_287702.1 CDS Z2259 NC_002655.2 2040412 2042130 R Rhs element protein complement(2040412..2042130) Escherichia coli O157:H7 str. EDL933 960774 NP_287703.1 CDS Z2261 NC_002655.2 2042057 2042560 R Rhs element protein complement(2042057..2042560) Escherichia coli O157:H7 str. EDL933 960775 NP_287704.1 CDS vgrE NC_002655.2 2042627 2044771 R Rhs element protein complement(2042627..2044771) Escherichia coli O157:H7 str. EDL933 960776 NP_287705.1 CDS Z2263 NC_002655.2 2044997 2045143 D No significant matches; Rhs element protein 2044997..2045143 Escherichia coli O157:H7 str. EDL933 960780 NP_287706.1 CDS Z2264 NC_002655.2 2045556 2045768 R hypothetical protein complement(2045556..2045768) Escherichia coli O157:H7 str. EDL933 960782 NP_287707.1 CDS Z2265 NC_002655.2 2045844 2046461 R transferase complement(2045844..2046461) Escherichia coli O157:H7 str. EDL933 960783 NP_287708.1 CDS ansP NC_002655.2 2046677 2048227 D L-asparagine permease 2046677..2048227 Escherichia coli O157:H7 str. EDL933 960787 NP_287709.1 CDS Z2267 NC_002655.2 2048342 2049403 R receptor complement(2048342..2049403) Escherichia coli O157:H7 str. EDL933 960790 NP_287710.1 CDS Z2268 NC_002655.2 2049645 2051747 D outer membrane receptor for iron transport 2049645..2051747 Escherichia coli O157:H7 str. EDL933 960791 NP_287711.1 CDS Z2269 NC_002655.2 2051783 2052505 R DNA-binding transcriptional regulator complement(2051783..2052505) Escherichia coli O157:H7 str. EDL933 960792 NP_287712.1 CDS yncB NC_002655.2 2052646 2053776 R oxidoreductase complement(2052646..2053776) Escherichia coli O157:H7 str. EDL933 960806 NP_287713.1 CDS Z2271 NC_002655.2 2053864 2054382 D resistance protein 2053864..2054382 Escherichia coli O157:H7 str. EDL933 960808 NP_287714.1 CDS Z2272 NC_002655.2 2054379 2054828 D hypothetical protein 2054379..2054828 Escherichia coli O157:H7 str. EDL933 960812 NP_287715.1 CDS Z2273 NC_002655.2 2054829 2055062 R hypothetical protein complement(2054829..2055062) Escherichia coli O157:H7 str. EDL933 960818 NP_287716.1 CDS Z2274 NC_002655.2 2055148 2055369 R hypothetical protein complement(2055148..2055369) Escherichia coli O157:H7 str. EDL933 960819 NP_287717.1 CDS Z2275 NC_002655.2 2055708 2057132 R catalyzes the formation of 4-aminobutanoate from 4-aminobutanal; involved in putrescine degradation; gamma-aminobutyraldehyde dehydrogenase complement(2055708..2057132) Escherichia coli O157:H7 str. EDL933 960824 NP_287718.1 CDS Z2276 NC_002655.2 2057154 2057948 R transport system permease complement(2057154..2057948) Escherichia coli O157:H7 str. EDL933 960825 NP_287719.1 CDS Z2277 NC_002655.2 2057938 2058879 R transport system permease complement(2057938..2058879) Escherichia coli O157:H7 str. EDL933 960829 NP_287720.1 CDS Z2278 NC_002655.2 2058880 2059893 R ABC transporter ATP-binding protein complement(2058880..2059893) Escherichia coli O157:H7 str. EDL933 960830 NP_287721.1 CDS Z2279 NC_002655.2 2059911 2061056 R transporter complement(2059911..2061056) Escherichia coli O157:H7 str. EDL933 960831 NP_287722.1 CDS Z2280 NC_002655.2 2061301 2062707 R multifunctional transcriptional regulator/ABC transporter ATP-binding protein complement(2061301..2062707) Escherichia coli O157:H7 str. EDL933 960832 NP_287723.1 CDS Z2281 NC_002655.2 2062786 2063223 R hypothetical protein complement(2062786..2063223) Escherichia coli O157:H7 str. EDL933 960844 NP_287724.1 CDS Z2282 NC_002655.2 2063263 2063460 D hypothetical protein 2063263..2063460 Escherichia coli O157:H7 str. EDL933 960899 NP_287725.1 CDS Z2283 NC_002655.2 2063646 2063876 D hypothetical protein 2063646..2063876 Escherichia coli O157:H7 str. EDL933 960921 NP_287726.1 CDS ydcP NC_002655.2 2063968 2065971 R collagenase complement(2063968..2065971) Escherichia coli O157:H7 str. EDL933 960922 NP_287727.1 CDS ydcN NC_002655.2 2066002 2066538 R hypothetical protein complement(2066002..2066538) Escherichia coli O157:H7 str. EDL933 960929 NP_287728.1 CDS Z2286 NC_002655.2 2066573 2067802 D membrane transport protein 2066573..2067802 Escherichia coli O157:H7 str. EDL933 960944 NP_287729.1 CDS Z2287 NC_002655.2 2067837 2068505 R hypothetical protein complement(2067837..2068505) Escherichia coli O157:H7 str. EDL933 960969 NP_287730.1 CDS tehB NC_002655.2 2068811 2069404 R with TehA confers resistance to tellurite; tellurite resistance protein TehB complement(2068811..2069404) Escherichia coli O157:H7 str. EDL933 960971 NP_287731.1 CDS tehA NC_002655.2 2069401 2070393 R potassium-tellurite ethidium and proflavin transporter complement(2069401..2070393) Escherichia coli O157:H7 str. EDL933 960974 NP_287732.1 CDS Z2290 NC_002655.2 2070517 2071497 D hypothetical protein 2070517..2071497 Escherichia coli O157:H7 str. EDL933 960976 NP_287733.1 CDS Z2291 NC_002655.2 2071732 2072028 R hypothetical protein complement(2071732..2072028) Escherichia coli O157:H7 str. EDL933 960977 NP_287734.1 CDS ydcH NC_002655.2 2072091 2072258 R hypothetical protein complement(2072091..2072258) Escherichia coli O157:H7 str. EDL933 960981 NP_287735.1 CDS Z2293 NC_002655.2 2072331 2072534 D hypothetical protein 2072331..2072534 Escherichia coli O157:H7 str. EDL933 960983 NP_287736.1 CDS mdoD NC_002655.2 2072455 2074110 R involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans; glucan biosynthesis protein D complement(2072455..2074110) Escherichia coli O157:H7 str. EDL933 960984 NP_287737.1 CDS Z2296 NC_002655.2 2074336 2074860 R hypothetical protein complement(2074336..2074860) Escherichia coli O157:H7 str. EDL933 960985 NP_287738.1 CDS Z2297 NC_002655.2 2074877 2075515 R hypothetical protein complement(2074877..2075515) Escherichia coli O157:H7 str. EDL933 960986 NP_287739.1 CDS Z2298 NC_002655.2 2075484 2075681 R hypothetical protein complement(2075484..2075681) Escherichia coli O157:H7 str. EDL933 960987 NP_287740.1 CDS Z2299 NC_002655.2 2075757 2076821 D LysR family transcriptional regulator 2075757..2076821 Escherichia coli O157:H7 str. EDL933 960988 NP_287741.1 CDS trg NC_002655.2 2076859 2078499 R methyl-accepting chemotaxis protein III, ribose sensor receptor complement(2076859..2078499) Escherichia coli O157:H7 str. EDL933 960989 NP_287742.1 CDS Z2301 NC_002655.2 2078840 2079007 D hypothetical protein 2078840..2079007 Escherichia coli O157:H7 str. EDL933 960990 NP_287743.1 CDS ydcA NC_002655.2 2079119 2079292 R hypothetical protein complement(2079119..2079292) Escherichia coli O157:H7 str. EDL933 960991 NP_287744.1 CDS cybB NC_002655.2 2079537 2080103 R B-type di-heme cytochrome with a major alpha-absorption peak at 561 nm and a minor peak at 555 nm; cytochrome b561 complement(2079537..2080103) Escherichia coli O157:H7 str. EDL933 960992 NP_287745.1 CDS gapC NC_002655.2 2080256 2081257 D glyceraldehyde-3-phosphate dehydrogenase 2080256..2081257 Escherichia coli O157:H7 str. EDL933 960993 NP_287746.1 CDS aldA NC_002655.2 2081299 2082738 R NAD-linked; aldehyde dehydrogenase complement(2081299..2082738) Escherichia coli O157:H7 str. EDL933 960994 NP_287747.1 CDS ydcF NC_002655.2 2082935 2083735 R hypothetical protein complement(2082935..2083735) Escherichia coli O157:H7 str. EDL933 960995 NP_287748.1 CDS Z2309 NC_002655.2 2083851 2084228 R No significant matches; hypothetical protein complement(2083851..2084228) Escherichia coli O157:H7 str. EDL933 960996 NP_287749.1 CDS Z2310 NC_002655.2 2084353 2084784 R No significant matches; hypothetical protein complement(2084353..2084784) Escherichia coli O157:H7 str. EDL933 960997 NP_287750.1 CDS Z2311 NC_002655.2 2084771 2085139 R No significant matches; hypothetical protein complement(2084771..2085139) Escherichia coli O157:H7 str. EDL933 960998 NP_287751.1 CDS Z2312 NC_002655.2 2085114 2085539 R No significant matches; hypothetical protein complement(2085114..2085539) Escherichia coli O157:H7 str. EDL933 960999 NP_287752.1 CDS hrpA NC_002655.2 2085685 2089530 R involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain; ATP-dependent RNA helicase HrpA complement(2085685..2089530) Escherichia coli O157:H7 str. EDL933 961000 NP_287753.1 CDS acpD NC_002655.2 2089788 2090393 D FMN-dependent; requires NADH; catalyzes the cleavage of azo bond in aromatic azo compounds; azoreductase 2089788..2090393 Escherichia coli O157:H7 str. EDL933 961001 NP_287754.1 CDS ynbD NC_002655.2 2090444 2091736 R hypothetical protein complement(2090444..2091736) Escherichia coli O157:H7 str. EDL933 961002 NP_287755.1 CDS Z2317 NC_002655.2 2091750 2093507 R hypothetical protein complement(2091750..2093507) Escherichia coli O157:H7 str. EDL933 961003 NP_287756.1 CDS Z2318 NC_002655.2 2093523 2094419 R phosphatidate cytidylyltransferase complement(2093523..2094419) Escherichia coli O157:H7 str. EDL933 961004 NP_287757.1 CDS Z2319 NC_002655.2 2094419 2095030 R hypothetical protein complement(2094419..2095030) Escherichia coli O157:H7 str. EDL933 961005 NP_287758.1 CDS ydbD NC_002655.2 2095195 2097507 R hypothetical protein complement(2095195..2097507) Escherichia coli O157:H7 str. EDL933 961006 NP_287759.1 CDS ydbC NC_002655.2 2097565 2098425 R oxidoreductase complement(2097565..2098425) Escherichia coli O157:H7 str. EDL933 961007 NP_287760.1 CDS Z2322 NC_002655.2 2098645 2101104 R hypothetical protein complement(2098645..2101104) Escherichia coli O157:H7 str. EDL933 961008 NP_287761.1 CDS Z2323 NC_002655.2 2101324 2104044 R hypothetical protein complement(2101324..2104044) Escherichia coli O157:H7 str. EDL933 961009 NP_287762.1 CDS Z2325 NC_002655.2 2104315 2104434 R No significant matches; hypothetical protein complement(2104315..2104434) Escherichia coli O157:H7 str. EDL933 961010 NP_287763.1 CDS ydbL NC_002655.2 2104774 2105103 R hypothetical protein complement(2104774..2105103) Escherichia coli O157:H7 str. EDL933 961011 NP_287764.1 CDS ynbE NC_002655.2 2105105 2105290 R hypothetical protein complement(2105105..2105290) Escherichia coli O157:H7 str. EDL933 961012 NP_287765.1 CDS ydbH NC_002655.2 2105287 2107926 R hypothetical protein complement(2105287..2107926) Escherichia coli O157:H7 str. EDL933 961013 NP_287766.1 CDS ldhA NC_002655.2 2108135 2109124 D Catalyzes the reduction of sulfopyruvate to (R)-sulfolactate much more efficiently than the reverse reaction. Also catalyzes the reduction of oxaloacetate, alpha-ketoglutarate, and to a much lower extent, KHTCA, but not pyruvate. Involved in the biosynthes; D-lactate dehydrogenase 2108135..2109124 Escherichia coli O157:H7 str. EDL933 961014 NP_287767.1 CDS hslJ NC_002655.2 2109236 2109658 D heat-inducible protein 2109236..2109658 Escherichia coli O157:H7 str. EDL933 961015 NP_287768.1 CDS ydbK NC_002655.2 2110195 2113719 D oxidoreductase, Fe-S subunit 2110195..2113719 Escherichia coli O157:H7 str. EDL933 961016 NP_287769.1 CDS Z2333 NC_002655.2 2114085 2114456 D hypothetical protein 2114085..2114456 Escherichia coli O157:H7 str. EDL933 961017 NP_287770.1 CDS Z2334 NC_002655.2 2114431 2115198 D hypothetical protein 2114431..2115198 Escherichia coli O157:H7 str. EDL933 961018 NP_287771.1 CDS ynaF NC_002655.2 2115267 2115773 D hypothetical protein 2115267..2115773 Escherichia coli O157:H7 str. EDL933 961019 NP_287772.1 CDS Z2337 NC_002655.2 2116354 2116995 R hypothetical protein complement(2116354..2116995) Escherichia coli O157:H7 str. EDL933 961020 NP_287773.1 CDS Z2338 NC_002655.2 2117077 2117706 R hypothetical protein complement(2117077..2117706) Escherichia coli O157:H7 str. EDL933 961021 NP_287774.1 CDS Z2339 NC_002655.2 2117779 2118354 R hypothetical protein complement(2117779..2118354) Escherichia coli O157:H7 str. EDL933 961022 NP_287775.1 CDS Z2340 NC_002655.2 2118738 2120057 R tail fiber protein encoded by prophage CP-933R complement(2118738..2120057) Escherichia coli O157:H7 str. EDL933 961023 NP_287776.2 CDS Z2342 NC_002655.2 2120116 >2120442 R outer membrane protein Lom encoded by prophage CP-933R complement(2120116..>2120442) Escherichia coli O157:H7 str. EDL933 961024 NP_287777.1 CDS Z2343 NC_002655.2 2120536 2120817 R outer membrane protein Lom encoded by prophage CP-933R complement(2120536..2120817) Escherichia coli O157:H7 str. EDL933 961025 NP_287778.1 CDS Z2344 NC_002655.2 2120885 2123818 R tail fiber protein encoded by prophage CP-933R complement(2120885..2123818) Escherichia coli O157:H7 str. EDL933 961026 NP_287779.1 CDS Z2346 NC_002655.2 2123826 2124359 R phage tail protein encoded by prophage CP-933R complement(2123826..2124359) Escherichia coli O157:H7 str. EDL933 961027 NP_287780.1 CDS Z2347 NC_002655.2 2124196 2125020 D copper-zinc superoxide dismutase encoded within prophage CP-933R 2124196..2125020 Escherichia coli O157:H7 str. EDL933 961030 NP_287781.1 CDS Z2348 NC_002655.2 2125211 2125345 R phage tail protein encoded by prophage CP-933R complement(2125211..2125345) Escherichia coli O157:H7 str. EDL933 961033 NP_287782.1 CDS Z2350 NC_002655.2 2125364 2125642 R phage tail protein encoded by prophage CP-933R complement(2125364..2125642) Escherichia coli O157:H7 str. EDL933 961034 NP_287783.1 CDS Z2351 NC_002655.2 2125787 2126461 R tail component of prophage CP-933R complement(2125787..2126461) Escherichia coli O157:H7 str. EDL933 961037 NP_287784.1 CDS Z2352 NC_002655.2 2126541 2127239 R tail component of prophage CP-933R complement(2126541..2127239) Escherichia coli O157:H7 str. EDL933 961047 NP_287785.1 CDS Z2353 NC_002655.2 2127239 2127568 R tail component of prophage CP-933R complement(2127239..2127568) Escherichia coli O157:H7 str. EDL933 961050 NP_287786.1 CDS Z2354 NC_002655.2 2127565 2128329 R tail component of prophage CP-933R complement(2127565..2128329) Escherichia coli O157:H7 str. EDL933 961055 NP_287787.1 CDS Z2355 NC_002655.2 2128281 2130143 R tail component of prophage CP-933R complement(2128281..2130143) Escherichia coli O157:H7 str. EDL933 961059 NP_287788.1 CDS Z2356 NC_002655.2 2130124 2130537 R tail component of prophage CP-933R complement(2130124..2130537) Escherichia coli O157:H7 str. EDL933 961066 NP_287789.1 CDS Z2357 NC_002655.2 2130564 2131067 R tail component of prophage CP-933R complement(2130564..2131067) Escherichia coli O157:H7 str. EDL933 961078 NP_287790.1 CDS Z2358 NC_002655.2 2131009 2131671 R tail component of prophage CP-933R complement(2131009..2131671) Escherichia coli O157:H7 str. EDL933 961087 NP_287791.1 CDS Z2359 NC_002655.2 2131731 2131997 R capsid structural protein of prophage CP-933R complement(2131731..2131997) Escherichia coli O157:H7 str. EDL933 961089 NP_287792.1 CDS Z2360 NC_002655.2 2132055 2132402 R capsid protein of prophage CP-933R complement(2132055..2132402) Escherichia coli O157:H7 str. EDL933 961096 NP_287793.1 CDS Z2361 NC_002655.2 2132439 2133944 R capsid assembly protein of prophage CP-933R complement(2132439..2133944) Escherichia coli O157:H7 str. EDL933 961099 NP_287794.1 CDS Z2362 NC_002655.2 2133934 2135526 R capsid protein of prophage CP-933R complement(2133934..2135526) Escherichia coli O157:H7 str. EDL933 961100 NP_287795.1 CDS Z2363 NC_002655.2 2135523 2135663 R DNA packaging protein of prophage CP-933R complement(2135523..2135663) Escherichia coli O157:H7 str. EDL933 961101 NP_287796.1 CDS Z2364 NC_002655.2 2135713 2137677 R DNA packaging protein of prophage CP-933R; terminase large subunit complement(2135713..2137677) Escherichia coli O157:H7 str. EDL933 961103 NP_287797.1 CDS Z2365 NC_002655.2 2137613 2138122 R DNA packaging protein of prophage CP-933R; terminase small subunit complement(2137613..2138122) Escherichia coli O157:H7 str. EDL933 961104 NP_287798.1 CDS Z2366 NC_002655.2 2138517 2138741 D hypothetical protein 2138517..2138741 Escherichia coli O157:H7 str. EDL933 961105 NP_287799.1 CDS Z2367 NC_002655.2 2139140 2139253 D No significant matches; hypothetical protein 2139140..2139253 Escherichia coli O157:H7 str. EDL933 961106 NP_287800.1 CDS Z2368 NC_002655.2 2139379 2139519 R No significant matches; hypothetical protein complement(2139379..2139519) Escherichia coli O157:H7 str. EDL933 961108 NP_287801.1 CDS Z2369 NC_002655.2 2139602 2140069 R endopeptidase Rz of prophage CP-933R complement(2139602..2140069) Escherichia coli O157:H7 str. EDL933 961109 NP_287802.1 CDS Z2370 NC_002655.2 2140221 2140403 R No significant matches; hypothetical protein complement(2140221..2140403) Escherichia coli O157:H7 str. EDL933 961110 NP_287803.1 CDS Z2371 NC_002655.2 2140559 2141092 R lysozyme R of prophage CP-933R complement(2140559..2141092) Escherichia coli O157:H7 str. EDL933 961111 NP_287804.1 CDS Z2372 NC_002655.2 2141118 2141489 R hypothetical protein complement(2141118..2141489) Escherichia coli O157:H7 str. EDL933 961113 NP_287805.1 CDS Z2374 NC_002655.2 2141494 2141700 R holin protein of prophage CP-933R complement(2141494..2141700) Escherichia coli O157:H7 str. EDL933 961114 NP_287806.1 CDS Z2375 NC_002655.2 2142020 2142346 D hypothetical protein 2142020..2142346 Escherichia coli O157:H7 str. EDL933 961115 NP_287807.1 CDS Z2376 NC_002655.2 2142587 2143234 D IS629 transposase within prophage CP-933R 2142587..2143234 Escherichia coli O157:H7 str. EDL933 961116 NP_287808.1 CDS Z2377 NC_002655.2 2143317 2145167 R hypothetical protein complement(2143317..2145167) Escherichia coli O157:H7 str. EDL933 961117 NP_287809.1 CDS Z2378 NC_002655.2 2145579 2145746 R No significant matches; hypothetical protein complement(2145579..2145746) Escherichia coli O157:H7 str. EDL933 961118 NP_287810.1 CDS Z2379 NC_002655.2 2145743 2146237 R hypothetical protein complement(2145743..2146237) Escherichia coli O157:H7 str. EDL933 961119 NP_287811.1 CDS Z2382 NC_002655.2 2146736 2146900 R No significant matches; hypothetical protein complement(2146736..2146900) Escherichia coli O157:H7 str. EDL933 961124 NP_287812.1 CDS Z2384 NC_002655.2 2146893 2147411 R No significant matches; hypothetical protein complement(2146893..2147411) Escherichia coli O157:H7 str. EDL933 961125 NP_287813.1 CDS Z2385 NC_002655.2 2147578 2148177 R No significant matches; hypothetical protein complement(2147578..2148177) Escherichia coli O157:H7 str. EDL933 961126 NP_287814.1 CDS Z2386 NC_002655.2 2148677 2150068 D No significant matches; hypothetical protein 2148677..2150068 Escherichia coli O157:H7 str. EDL933 961127 NP_287815.1 CDS Z2387 NC_002655.2 2150065 2151057 D No significant matches; hypothetical protein 2150065..2151057 Escherichia coli O157:H7 str. EDL933 961128 NP_287816.1 CDS Z2389 NC_002655.2 2151025 2152176 R DNA modification methyltransferase encoded within prophage CP-933R complement(2151025..2152176) Escherichia coli O157:H7 str. EDL933 961129 NP_287817.1 CDS Z2390 NC_002655.2 2152608 2152865 R hypothetical protein complement(2152608..2152865) Escherichia coli O157:H7 str. EDL933 961130 NP_287818.1 CDS Z2391 NC_002655.2 2152932 2153093 R hypothetical protein complement(2152932..2153093) Escherichia coli O157:H7 str. EDL933 961131 NP_287819.1 CDS Z2392 NC_002655.2 2153104 2153367 R No significant matches; hypothetical protein complement(2153104..2153367) Escherichia coli O157:H7 str. EDL933 961132 NP_287820.1 CDS Z2393 NC_002655.2 2153619 2153831 R No significant matches; hypothetical protein complement(2153619..2153831) Escherichia coli O157:H7 str. EDL933 961134 NP_287821.1 CDS Z2394 NC_002655.2 2153937 2154359 R No significant matches; hypothetical protein complement(2153937..2154359) Escherichia coli O157:H7 str. EDL933 961136 NP_287822.1 CDS Z2395 NC_002655.2 2154375 2155187 R hypothetical protein complement(2154375..2155187) Escherichia coli O157:H7 str. EDL933 961137 NP_287823.1 CDS Z2396 NC_002655.2 2155159 2155905 R acts to load the DnaB helicase onto the intiation site durning DNA replication; replication protein complement(2155159..2155905) Escherichia coli O157:H7 str. EDL933 961138 NP_287824.1 CDS Z2397 NC_002655.2 2155912 2156700 R hypothetical protein complement(2155912..2156700) Escherichia coli O157:H7 str. EDL933 961139 NP_287825.1 CDS Z2398 NC_002655.2 2156778 2157200 R hypothetical protein complement(2156778..2157200) Escherichia coli O157:H7 str. EDL933 961140 NP_287826.1 CDS Z2399 NC_002655.2 2157197 2157523 R regulatory protein Cro of prophage CP-933R complement(2157197..2157523) Escherichia coli O157:H7 str. EDL933 961142 NP_287827.1 CDS Z2400 NC_002655.2 2157531 2157827 D represssor protein encoded within prophage CP-933R 2157531..2157827 Escherichia coli O157:H7 str. EDL933 961143 NP_287828.1 CDS Z2402 NC_002655.2 2158194 2158373 D hypothetical protein 2158194..2158373 Escherichia coli O157:H7 str. EDL933 961144 NP_287829.1 CDS Z2403 NC_002655.2 2158351 2158527 R hypothetical protein complement(2158351..2158527) Escherichia coli O157:H7 str. EDL933 961145 NP_287830.1 CDS sieB NC_002655.2 2158536 2159147 R prophage CP-933R superinfection exclusion protein complement(2158536..2159147) Escherichia coli O157:H7 str. EDL933 961147 NP_287831.1 CDS kil NC_002655.2 2159454 2159687 D Rac prophage Kil protein; Kil overexpression leads to morphological defects and inhibits cell division; FtsZ inhibitor protein 2159454..2159687 Escherichia coli O157:H7 str. EDL933 961149 NP_287832.1 CDS racC NC_002655.2 2159932 2160207 D Rac prophage hypothetical protein; hypothetical protein 2159932..2160207 Escherichia coli O157:H7 str. EDL933 961150 NP_287833.1 CDS recE NC_002655.2 2160309 2162909 D The RecE (also known as exonuclease VIII) pathway is an alternative pathway for the initiation of homologous recombination in Escherichia coli. The RecE pathway is activated in recB, recC sbcA (suppressors of recB and recC) mutants. Activation of the RecE pathway results in the production of at least two phage proteins relevant for recombinational repair. RecE is a duplex DNA-specific exonuclease which produces 3' overhangs in duplex DNA by preferentially degrading the 5'-ending strands. Recombinational repair of E.coli chromosomal DNA involves as well other proteins: RecA, RecF, RecJ, RecO, RecR, and RuvC.; exonuclease VIII 2160309..2162909 Escherichia coli O157:H7 str. EDL933 961151 NP_287834.1 CDS recT NC_002655.2 2162902 2163711 D recombination and repair protein RecT 2162902..2163711 Escherichia coli O157:H7 str. EDL933 961152 NP_287835.1 CDS lar NC_002655.2 2163767 2163916 D seems to be involved in restriction alleviation and enhancement of modification by EcoKI, but not in restriction alleviation of type III restriction systems; Rac prophage; restriction alleviation and modification protein 2163767..2163916 Escherichia coli O157:H7 str. EDL933 961165 NP_287836.1 CDS ydaC NC_002655.2 2163882 2164142 D Rac prophage; hypothetical protein 2163882..2164142 Escherichia coli O157:H7 str. EDL933 961168 NP_287837.1 CDS ydaQ NC_002655.2 2164218 2164457 D hypothetical protein 2164218..2164457 Escherichia coli O157:H7 str. EDL933 961170 NP_287838.1 CDS intR NC_002655.2 2164459 2165694 D integrase for prophage CP-933R 2164459..2165694 Escherichia coli O157:H7 str. EDL933 961182 NP_287839.1 CDS ydaO NC_002655.2 2165746 2166681 D TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs; C32 tRNA thiolase 2165746..2166681 Escherichia coli O157:H7 str. EDL933 961183 NP_287840.1 CDS dbpA NC_002655.2 2166810 2168183 R exhibits an RNA-dependent ATPase activity, specifically stimulated by bacterial 23S rRNA; ATP-dependent RNA helicase DbpA complement(2166810..2168183) Escherichia coli O157:H7 str. EDL933 961184 NP_287841.1 CDS zntB NC_002655.2 2168661 2169644 R zinc transporter complement(2168661..2169644) Escherichia coli O157:H7 str. EDL933 961186 NP_287842.1 CDS Z2421 NC_002655.2 2169839 2171131 D hypothetical protein 2169839..2171131 Escherichia coli O157:H7 str. EDL933 961215 NP_287843.1 CDS ydaL NC_002655.2 2171152 2171715 R hypothetical protein complement(2171152..2171715) Escherichia coli O157:H7 str. EDL933 961224 NP_287844.1 CDS ydaK NC_002655.2 2172045 2172953 R DNA-binding transcriptional regulator complement(2172045..2172953) Escherichia coli O157:H7 str. EDL933 961256 NP_287845.1 CDS ydaJ NC_002655.2 2173129 2174439 D aminohydrolase 2173129..2174439 Escherichia coli O157:H7 str. EDL933 961259 NP_287846.1 CDS Z2427 NC_002655.2 2174439 2175884 D hypothetical protein 2174439..2175884 Escherichia coli O157:H7 str. EDL933 961261 NP_287847.1 CDS Z2428 NC_002655.2 2175921 2176718 D pump protein; disrupted by IS629 2175921..2176718 Escherichia coli O157:H7 str. EDL933 961262 NP_287848.1 CDS Z2429 NC_002655.2 2176744 2177070 D hypothetical protein 2176744..2177070 Escherichia coli O157:H7 str. EDL933 961266 NP_287849.1 CDS Z2430 NC_002655.2 2177310 2177957 D transposase for IS629 2177310..2177957 Escherichia coli O157:H7 str. EDL933 961268 NP_287850.1 CDS Z2431 NC_002655.2 2178068 2178760 D pump protein; disrupted by IS629 2178068..2178760 Escherichia coli O157:H7 str. EDL933 961269 NP_287851.1 CDS ogt NC_002655.2 2178771 2179286 D O-6-alkylguanine-DNA:cysteine-protein methyltransferase 2178771..2179286 Escherichia coli O157:H7 str. EDL933 961272 NP_287852.1 CDS fnr NC_002655.2 2179481 2180233 D Global transcription factor that controls the expression of over 100 target genes in response to anoxia; fumarate/nitrate reduction transcriptional regulator 2179481..2180233 Escherichia coli O157:H7 str. EDL933 961273 NP_287853.1 CDS ydaA NC_002655.2 2180385 2181335 D with UspC and UspD is involved in resistance to UV irradiation; universal stress protein UspE 2180385..2181335 Escherichia coli O157:H7 str. EDL933 961275 NP_287854.1 CDS ynaJ NC_002655.2 2181385 2181642 R hypothetical protein complement(2181385..2181642) Escherichia coli O157:H7 str. EDL933 961276 NP_287855.1 CDS Z2437 NC_002655.2 2181886 2182917 D hypothetical protein 2181886..2182917 Escherichia coli O157:H7 str. EDL933 961278 NP_287856.1 CDS Z2438 NC_002655.2 2182968 2184602 R transport periplasmic protein complement(2182968..2184602) Escherichia coli O157:H7 str. EDL933 961280 NP_287857.1 CDS ycjZ NC_002655.2 2184918 2185817 R LysR family transcriptional regulator complement(2184918..2185817) Escherichia coli O157:H7 str. EDL933 961281 NP_287858.1 CDS Z2442 NC_002655.2 2185943 2186875 D hypothetical protein 2185943..2186875 Escherichia coli O157:H7 str. EDL933 961282 NP_287859.1 CDS Z2444 NC_002655.2 2186875 2187243 D hypothetical protein 2186875..2187243 Escherichia coli O157:H7 str. EDL933 961283 NP_287860.1 CDS Z2445 NC_002655.2 2187182 2187805 D hypothetical protein 2187182..2187805 Escherichia coli O157:H7 str. EDL933 961288 NP_287861.1 CDS Z2446 NC_002655.2 2187814 2188464 D hypothetical protein 2187814..2188464 Escherichia coli O157:H7 str. EDL933 961290 NP_287862.1 CDS ycjI NC_002655.2 2188695 2189483 D murein peptide amidase A 2188695..2189483 Escherichia coli O157:H7 str. EDL933 961294 NP_287863.1 CDS ycjG NC_002655.2 2189458 2190423 R muconate cycloisomerase I complement(2189458..2190423) Escherichia coli O157:H7 str. EDL933 961300 NP_287864.1 CDS tpx NC_002655.2 2190542 2191048 D antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein; thiol peroxidase 2190542..2191048 Escherichia coli O157:H7 str. EDL933 961304 NP_287865.1 CDS tyrR NC_002655.2 2191092 2192633 R regulates genes involved in the biosynthesis and transport of aromatic amino acids; DNA-binding transcriptional regulator TyrR complement(2191092..2192633) Escherichia coli O157:H7 str. EDL933 961305 NP_287866.1 CDS ycjF NC_002655.2 2192781 2193842 R hypothetical protein complement(2192781..2193842) Escherichia coli O157:H7 str. EDL933 961307 NP_287867.1 CDS ycjX NC_002655.2 2193839 2195236 R hypothetical protein complement(2193839..2195236) Escherichia coli O157:H7 str. EDL933 961308 NP_287868.1 CDS ycjW NC_002655.2 2195391 2196389 D LACI-type transcriptional regulator 2195391..2196389 Escherichia coli O157:H7 str. EDL933 961309 NP_287869.1 CDS ompG NC_002655.2 2196501 2197406 R hypothetical protein complement(2196501..2197406) Escherichia coli O157:H7 str. EDL933 961310 NP_287870.1 CDS ycjV NC_002655.2 2197451 2198533 R ABC transporter ATP-binding protein complement(2197451..2198533) Escherichia coli O157:H7 str. EDL933 961311 NP_287871.1 CDS ycjU NC_002655.2 2198547 2199206 R beta-phosphoglucomutase complement(2198547..2199206) Escherichia coli O157:H7 str. EDL933 961312 NP_287872.1 CDS ycjT NC_002655.2 2199203 2201470 R hypothetical protein complement(2199203..2201470) Escherichia coli O157:H7 str. EDL933 961313 NP_287873.1 CDS ycjS NC_002655.2 2201467 2202522 R dehydrogenase complement(2201467..2202522) Escherichia coli O157:H7 str. EDL933 961314 NP_287874.1 CDS Z2469 NC_002655.2 2202532 2203320 R transient receptor potential locus complement(2202532..2203320) Escherichia coli O157:H7 str. EDL933 961317 NP_287875.1 CDS ycjQ NC_002655.2 2203338 2204390 R oxidoreductase complement(2203338..2204390) Escherichia coli O157:H7 str. EDL933 961318 NP_287876.1 CDS ycjP NC_002655.2 2204421 2205263 R transport system permease complement(2204421..2205263) Escherichia coli O157:H7 str. EDL933 961319 NP_287877.1 CDS ycjO NC_002655.2 2205250 2206131 R binding-protein dependent transport protein complement(2205250..2206131) Escherichia coli O157:H7 str. EDL933 961322 NP_287878.1 CDS Z2474m NC_002655.2 2206152 2207444 R sugar-binding periplasmic protein complement(2206152..2207444) Escherichia coli O157:H7 str. EDL933 959646 NP_287879.1 CDS ycjM NC_002655.2 2207458 2209136 R glycosidase complement(join(2207458..2208810,2208810..2209136)) Escherichia coli O157:H7 str. EDL933 959629 NP_287880.1 CDS pspE NC_002655.2 2209347 2209661 R rhodanese; catalyzes the formation of thiocyanate from thiosulfate and hydrogen cyanide; thiosulfate:cyanide sulfurtransferase complement(2209347..2209661) Escherichia coli O157:H7 str. EDL933 961323 NP_287881.1 CDS pspD NC_002655.2 2209736 2209957 R peripheral inner membrane phage-shock protein complement(2209736..2209957) Escherichia coli O157:H7 str. EDL933 961326 NP_287882.1 CDS pspC NC_002655.2 2209966 2210325 R with PsbB forms toxin/antitoxin pair; activates the psp operon in response to phage infection, exposure to ethanol or osmotic shock; DNA-binding transcriptional activator PspC complement(2209966..2210325) Escherichia coli O157:H7 str. EDL933 961328 NP_287883.1 CDS pspB NC_002655.2 2210325 2210549 R acts together with PspC to induce psp operon during infection with phage, exposure to ethanol or osmotic shock; forms a complex with PspA and C; PspC is required for PspAB binding; phage shock protein B complement(2210325..2210549) Escherichia coli O157:H7 str. EDL933 961330 NP_287884.1 CDS pspA NC_002655.2 2210603 2211271 R involved in maintaining membrane potential under membrane stress conditions; also acts as a negative transcriptional regulator of the phage shock protein (psp) operon(pspABCDE) by regulating the transcriptional activator PspF; phage shock protein PspA complement(2210603..2211271) Escherichia coli O157:H7 str. EDL933 961336 NP_287885.2 CDS pspF NC_002655.2 2211438 2212415 D transcriptional activator for pspABCE which are induced in response to phage proteins, membrane altering stresses, and impaired proton expor; phage shock protein operon transcriptional activator 2211438..2212415 Escherichia coli O157:H7 str. EDL933 961337 NP_287886.1 CDS goaG NC_002655.2 2212546 2213811 R putrescine-inducible GABA aminotransferase; catalyzes the formation of glutamate and succinate semialdehyde from 4-aminobutyrate and 2-oxoglutarate; 4-aminobutyrate aminotransferase complement(2212546..2213811) Escherichia coli O157:H7 str. EDL933 961338 NP_287887.1 CDS ordL NC_002655.2 2213849 2215129 R oxidoreductase complement(2213849..2215129) Escherichia coli O157:H7 str. EDL933 961340 NP_287888.1 CDS aldH NC_002655.2 2215131 2216618 R catalyzes the formation of gamma-glutamyl-gamma-aminobutyrate from Gamma-glutamyl-gamma-aminobutyraldehyde; involved in putrescine degradation; gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase complement(2215131..2216618) Escherichia coli O157:H7 str. EDL933 961341 NP_287889.1 CDS ycjC NC_002655.2 2216768 2217325 R regulates genes involved in putrescine degradation; DNA-binding transcriptional repressor PuuR complement(2216768..2217325) Escherichia coli O157:H7 str. EDL933 961342 NP_287890.1 CDS puuD NC_002655.2 2217352 2218128 R catalyzes the degradation of gamma-glutamyl-gamma-aminobutyrate into glutamate and gamma-aminobutyrate; gamma-glutamyl-gamma-aminobutyrate hydrolase complement(2217352..2218128) Escherichia coli O157:H7 str. EDL933 961343 NP_287891.1 CDS Z2491 NC_002655.2 2218250 2219746 D glutamine synthetase 2218250..2219746 Escherichia coli O157:H7 str. EDL933 961344 NP_287892.1 CDS ycjJ NC_002655.2 2220049 2221434 D amino acid/amine transport protein 2220049..2221434 Escherichia coli O157:H7 str. EDL933 961345 NP_287893.1 CDS ymjA NC_002655.2 2221569 2221814 D hypothetical protein 2221569..2221814 Escherichia coli O157:H7 str. EDL933 961347 NP_287894.1 CDS sapA NC_002655.2 2222128 2223771 D peptide transport periplasmic protein 2222128..2223771 Escherichia coli O157:H7 str. EDL933 961348 NP_287895.1 CDS sapB NC_002655.2 2223768 2224733 D peptide transport permease 2223768..2224733 Escherichia coli O157:H7 str. EDL933 961349 NP_287896.1 CDS sapC NC_002655.2 2224720 2225610 D peptide transport permease 2224720..2225610 Escherichia coli O157:H7 str. EDL933 961350 NP_287897.1 CDS sapD NC_002655.2 2225610 2226602 D peptide ABC transporter ATP-binding protein 2225610..2226602 Escherichia coli O157:H7 str. EDL933 961351 NP_287898.1 CDS sapF NC_002655.2 2226604 2227410 D peptide ABC transporter ATP-binding protein 2226604..2227410 Escherichia coli O157:H7 str. EDL933 961352 NP_287899.1 CDS Z2501 NC_002655.2 2227462 2227902 R membrane transport protein complement(2227462..2227902) Escherichia coli O157:H7 str. EDL933 961355 NP_287900.1 CDS Z2503 NC_002655.2 2227907 2228626 R membrane transport protein complement(2227907..2228626) Escherichia coli O157:H7 str. EDL933 961357 NP_287901.1 CDS Z2504 NC_002655.2 2228635 2229072 R outer membrane channel protein complement(2228635..2229072) Escherichia coli O157:H7 str. EDL933 961358 NP_287902.1 CDS Z2506 NC_002655.2 2228981 2230009 R outer membrane channel protein complement(2228981..2230009) Escherichia coli O157:H7 str. EDL933 961359 NP_287903.1 CDS Z2507 NC_002655.2 2230013 2230180 R hypothetical protein complement(2230013..2230180) Escherichia coli O157:H7 str. EDL933 961360 NP_287904.1 CDS Z2508 NC_002655.2 2230032 2233115 R efflux pump protein complement(2230032..2233115) Escherichia coli O157:H7 str. EDL933 961362 NP_287905.1 CDS Z2509 NC_002655.2 2233115 2234236 R efflux pump protein complement(2233115..2234236) Escherichia coli O157:H7 str. EDL933 961364 NP_287906.1 CDS Z2510 NC_002655.2 2234385 2234951 R transcriptional repressor complement(2234385..2234951) Escherichia coli O157:H7 str. EDL933 961365 NP_287907.1 CDS Z2511 NC_002655.2 2234706 2235092 D No significant matches; hypothetical protein 2234706..2235092 Escherichia coli O157:H7 str. EDL933 961366 NP_287908.1 CDS fabI NC_002655.2 2235429 2236217 D Catalyzes a key regulatory step in fatty acid biosynthesis; enoyl-ACP reductase 2235429..2236217 Escherichia coli O157:H7 str. EDL933 961367 NP_287909.2 CDS yciW NC_002655.2 2236362 2237489 D oxidoreductase 2236362..2237489 Escherichia coli O157:H7 str. EDL933 961369 NP_287910.1 CDS rnb NC_002655.2 2237557 2239491 D Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction; exoribonuclease II 2237557..2239491 Escherichia coli O157:H7 str. EDL933 961370 NP_287911.1 CDS yciR NC_002655.2 2239726 2241711 D c-di-GMP phosphodiesterase; probably degrades signalling molecule c-di-GMP; RNase II stability modulator 2239726..2241711 Escherichia coli O157:H7 str. EDL933 961371 NP_287912.1 CDS Z2519 NC_002655.2 2241850 2242032 D No significant matches; hypothetical protein 2241850..2242032 Escherichia coli O157:H7 str. EDL933 961372 NP_287913.1 CDS Z2521 NC_002655.2 2242123 2242872 D DEOR-type transcriptional regulator 2242123..2242872 Escherichia coli O157:H7 str. EDL933 961374 NP_287914.1 CDS osmB NC_002655.2 2243141 2243359 D lipoprotein 2243141..2243359 Escherichia coli O157:H7 str. EDL933 961375 NP_287915.1 CDS yciH NC_002655.2 2243485 2243814 R involved in start site selection during the initiation of translation; translation initiation factor Sui1 complement(2243485..2243814) Escherichia coli O157:H7 str. EDL933 961376 NP_287916.1 CDS pyrF NC_002655.2 2243811 2244548 R OMP decarboxylase; OMPDCase; OMPdecase; type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase complement(2243811..2244548) Escherichia coli O157:H7 str. EDL933 961377 NP_287917.1 CDS yciM NC_002655.2 2244741 2245910 R tetratricopeptide repeat protein complement(2244741..2245910) Escherichia coli O157:H7 str. EDL933 961378 NP_287918.1 CDS yciS NC_002655.2 2245917 2246225 R hypothetical protein complement(2245917..2246225) Escherichia coli O157:H7 str. EDL933 961379 NP_287919.1 CDS pgpB NC_002655.2 2246374 2247138 R phosphatidylglycerophosphatase B complement(2246374..2247138) Escherichia coli O157:H7 str. EDL933 961380 NP_287920.1 CDS ribA NC_002655.2 2247309 2247899 D catalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate; GTP cyclohydrolase II 2247309..2247899 Escherichia coli O157:H7 str. EDL933 961381 NP_287921.1 CDS acnA NC_002655.2 2247963 2250638 R Catalyzes the conversion of citrate to isocitrate; aconitate hydratase complement(2247963..2250638) Escherichia coli O157:H7 str. EDL933 961382 NP_287922.1 CDS Z2533 NC_002655.2 2251011 2251190 R No significant matches; hypothetical protein complement(2251011..2251190) Escherichia coli O157:H7 str. EDL933 961383 NP_287923.1 CDS Z2534 NC_002655.2 2251181 2251321 R No significant matches; hypothetical protein complement(2251181..2251321) Escherichia coli O157:H7 str. EDL933 961385 NP_287924.1 CDS cysB NC_002655.2 2251640 2252614 R LysR-type transcriptional regulator; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon; autoregulates expression; crystal structure of Klebsiella aerogenes showed tetramer formation; transcriptional regulator CysB complement(2251640..2252614) Escherichia coli O157:H7 str. EDL933 961386 NP_287925.1 CDS topA NC_002655.2 2252824 2255421 R catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I complement(2252824..2255421) Escherichia coli O157:H7 str. EDL933 961387 NP_287926.1 CDS yciN NC_002655.2 2255801 2256052 D hypothetical protein 2255801..2256052 Escherichia coli O157:H7 str. EDL933 961388 NP_287927.1 CDS sohB NC_002655.2 2256088 2257137 R SohB; periplasmic protein; member of the peptidase S49 family; periplasmic protease complement(2256088..2257137) Escherichia coli O157:H7 str. EDL933 961389 NP_287928.1 CDS yciK NC_002655.2 2257357 2258115 D short chain dehydrogenase 2257357..2258115 Escherichia coli O157:H7 str. EDL933 961390 NP_287929.1 CDS btuR NC_002655.2 2258112 2258702 D catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide; cob(I)yrinic acid a,c-diamide adenosyltransferase 2258112..2258702 Escherichia coli O157:H7 str. EDL933 961391 NP_287930.1 CDS yciL NC_002655.2 2258742 2259614 R catalyzes the synthesis of pseudouridine from uracil-2605 in 23S ribosomal RNA; 23S rRNA pseudouridylate synthase B complement(2258742..2259614) Escherichia coli O157:H7 str. EDL933 961392 NP_287931.1 CDS Z2542 NC_002655.2 2259827 2261410 R hypothetical protein complement(2259827..2261410) Escherichia coli O157:H7 str. EDL933 961393 NP_287932.1 CDS yciO NC_002655.2 2261438 2262094 R hypothetical protein complement(2261438..2262094) Escherichia coli O157:H7 str. EDL933 961394 NP_287933.1 CDS yciV NC_002655.2 2262055 2262936 R hypothetical protein complement(2262055..2262936) Escherichia coli O157:H7 str. EDL933 961395 NP_287935.1 CDS trpE NC_002655.2 2263210 2264773 D with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I join(2263210..2264475,2264477..2264773) Escherichia coli O157:H7 str. EDL933 959632 NP_287936.1 CDS trpD NC_002655.2 2264773 2266368 D bifunctional anthranilate synthase II/anthranilate phosphoribosyltransferase; TrpD; forms a heterotetramer with Trp E and the complex catalyzes the formation of anthranilate from chorismate and glutamine; also catalyzes the formation of N-(5-phospho-D-ribosyl)-anthranilate from athranilate and 5-phospho-alpha-D-ribose 1-diphosphate; functions in tryptophan biosynthesis; bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase 2264773..2266368 Escherichia coli O157:H7 str. EDL933 961397 NP_287937.1 CDS trpC NC_002655.2 2266369 2267730 D monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate; bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase 2266369..2267730 Escherichia coli O157:H7 str. EDL933 961398 NP_287938.1 CDS trpB NC_002655.2 2267742 2268935 D catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta 2267742..2268935 Escherichia coli O157:H7 str. EDL933 961399 NP_287939.1 CDS trpA NC_002655.2 2268935 2269741 D catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha 2268935..2269741 Escherichia coli O157:H7 str. EDL933 961400 NP_287940.1 CDS yciG NC_002655.2 2270098 2270301 D hypothetical protein 2270098..2270301 Escherichia coli O157:H7 str. EDL933 961402 NP_287941.1 CDS yciF NC_002655.2 2270387 2270887 D hypothetical protein 2270387..2270887 Escherichia coli O157:H7 str. EDL933 961403 NP_287942.1 CDS yciE NC_002655.2 2270933 2271439 D hypothetical protein 2270933..2271439 Escherichia coli O157:H7 str. EDL933 961404 NP_287943.1 CDS Z2557 NC_002655.2 2271499 2271606 R hypothetical protein complement(2271499..2271606) Escherichia coli O157:H7 str. EDL933 961405 NP_287944.1 CDS Z2558 NC_002655.2 2272056 2272193 R No significant matches; hypothetical protein complement(2272056..2272193) Escherichia coli O157:H7 str. EDL933 961406 NP_287945.1 CDS Z2560 NC_002655.2 2272753 2273262 R hypothetical protein complement(2272753..2273262) Escherichia coli O157:H7 str. EDL933 961408 NP_287946.1 CDS Z2561 NC_002655.2 2273635 2273799 D transposase (partial) 2273635..2273799 Escherichia coli O157:H7 str. EDL933 961409 NP_287947.1 CDS Z2562 NC_002655.2 2274033 2274284 D transposase (partial) 2274033..2274284 Escherichia coli O157:H7 str. EDL933 961410 NP_287948.1 CDS Z2563 NC_002655.2 2274294 2274476 D transposase (partial) 2274294..2274476 Escherichia coli O157:H7 str. EDL933 961411 NP_287949.1 CDS Z2565 NC_002655.2 2274910 2275500 R chaperone protein complement(2274910..2275500) Escherichia coli O157:H7 str. EDL933 961412 NP_287950.1 CDS Z6010 NC_002655.2 2275684 2276331 D hypothetical protein 2275684..2276331 Escherichia coli O157:H7 str. EDL933 961413 NP_287951.1 CDS Z6011 NC_002655.2 2276468 2276653 R No Hits; hypothetical protein complement(2276468..2276653) Escherichia coli O157:H7 str. EDL933 961414 NP_287952.1 CDS Z6012 NC_002655.2 2277086 2277355 R hypothetical protein complement(2277086..2277355) Escherichia coli O157:H7 str. EDL933 961415 NP_287953.1 CDS Z6014 NC_002655.2 2277639 2278040 D hypothetical protein 2277639..2278040 Escherichia coli O157:H7 str. EDL933 961416 NP_287954.1 CDS Z6015 NC_002655.2 2278037 2278384 D hypothetical protein 2278037..2278384 Escherichia coli O157:H7 str. EDL933 961417 NP_287955.1 CDS Z6016 NC_002655.2 2278434 2279972 D hypothetical protein 2278434..2279972 Escherichia coli O157:H7 str. EDL933 961420 NP_287956.1 CDS Z6017 NC_002655.2 2280257 2280604 D transposase 2280257..2280604 Escherichia coli O157:H7 str. EDL933 961421 NP_287957.1 CDS Z6019 NC_002655.2 2280634 2280891 D transposase 2280634..2280891 Escherichia coli O157:H7 str. EDL933 961427 NP_287958.1 CDS Z6020 NC_002655.2 2280938 2281507 R hypothetical protein complement(2280938..2281507) Escherichia coli O157:H7 str. EDL933 961428 NP_287959.1 CDS Z6021 NC_002655.2 2281573 2282484 R hypothetical protein complement(2281573..2282484) Escherichia coli O157:H7 str. EDL933 961429 NP_287960.1 CDS Z6022 NC_002655.2 2282949 2283650 D integrase fragment 2282949..2283650 Escherichia coli O157:H7 str. EDL933 961430 NP_287961.1 CDS Z6024 NC_002655.2 2284311 2285636 D hypothetical protein 2284311..2285636 Escherichia coli O157:H7 str. EDL933 961432 NP_287962.1 CDS Z6025 NC_002655.2 2285976 2286506 R hypothetical protein complement(2285976..2286506) Escherichia coli O157:H7 str. EDL933 961434 NP_287963.1 CDS Z6026 NC_002655.2 2286663 2286932 R hypothetical protein complement(2286663..2286932) Escherichia coli O157:H7 str. EDL933 961435 NP_287964.1 CDS Z6027 NC_002655.2 2286934 2288247 R tail fiber protein of cryptic prophage CP-933P complement(2286934..2288247) Escherichia coli O157:H7 str. EDL933 961436 NP_287965.1 CDS lomP NC_002655.2 2288399 2288998 R Lom-like outer membrane protein of cryptic prophage CP-933P complement(2288399..2288998) Escherichia coli O157:H7 str. EDL933 961437 NP_287966.1 CDS Z6029 NC_002655.2 2289066 2291414 R tail component of cryptic prophage CP-933P complement(2289066..2291414) Escherichia coli O157:H7 str. EDL933 961438 NP_287967.1 CDS Z6030 NC_002655.2 2291363 2292718 R tail component of cryptic prophage CP-933P complement(2291363..2292718) Escherichia coli O157:H7 str. EDL933 961439 NP_287968.1 CDS Z6031 NC_002655.2 2292880 2293560 R tail assembly protein of cryptic prophage CP-933P complement(2292880..2293560) Escherichia coli O157:H7 str. EDL933 961440 NP_287969.1 CDS Z6032 NC_002655.2 2293458 2294132 R tail assembly protein of cryptic prophage CP-933P complement(2293458..2294132) Escherichia coli O157:H7 str. EDL933 961441 NP_287970.1 CDS Z6033 NC_002655.2 2294212 2294910 R tail component of cryptic prophage CP-933P complement(2294212..2294910) Escherichia coli O157:H7 str. EDL933 961443 NP_287971.1 CDS Z6034 NC_002655.2 2295244 2298486 R tail component of cryptic prophage CP-933P complement(2295244..2298486) Escherichia coli O157:H7 str. EDL933 961445 NP_287972.1 CDS Z6035 NC_002655.2 2298534 2298815 R tail assembly protein of cryptic prophage CP-933P complement(2298534..2298815) Escherichia coli O157:H7 str. EDL933 961448 NP_287973.1 CDS Z6036 NC_002655.2 2298839 2299261 R tail assembly protein of cryptic prophage CP-933P complement(2298839..2299261) Escherichia coli O157:H7 str. EDL933 961451 NP_287974.1 CDS Z6037 NC_002655.2 2299228 2300013 R tail component of cryptic prophage CP-933P complement(2299228..2300013) Escherichia coli O157:H7 str. EDL933 961452 NP_287975.1 CDS Z6038 NC_002655.2 2300010 2300354 R structural component of cryptic prophage CP-933P complement(2300010..2300354) Escherichia coli O157:H7 str. EDL933 961455 NP_287976.1 CDS Z6039 NC_002655.2 2300351 2300797 R structural component of cryptic prophage CP-933P complement(2300351..2300797) Escherichia coli O157:H7 str. EDL933 961456 NP_287977.1 CDS Z6040 NC_002655.2 2300794 2301051 R head-tail adaptor of cryptic prophage CP-933P complement(2300794..2301051) Escherichia coli O157:H7 str. EDL933 961458 NP_287978.1 CDS Z6041 NC_002655.2 2301154 2301480 R hypothetical protein complement(2301154..2301480) Escherichia coli O157:H7 str. EDL933 961459 NP_287979.1 CDS Z6042 NC_002655.2 2301483 2304062 R hypothetical protein complement(2301483..2304062) Escherichia coli O157:H7 str. EDL933 961460 NP_287980.1 CDS Z6043 NC_002655.2 2304008 2304229 R No Hits; hypothetical protein complement(2304008..2304229) Escherichia coli O157:H7 str. EDL933 961461 NP_287981.1 CDS Z6044 NC_002655.2 2304274 2306211 R hypothetical protein complement(2304274..2306211) Escherichia coli O157:H7 str. EDL933 961462 NP_287982.1 CDS Z6045 NC_002655.2 2306275 2307936 R terminase subunit encoded by cryptic prophage CP-933P complement(2306275..2307936) Escherichia coli O157:H7 str. EDL933 961463 NP_287983.1 CDS Z6046 NC_002655.2 2307933 2308496 R terminase subunit encoded by cryptic prophage CP-933P complement(2307933..2308496) Escherichia coli O157:H7 str. EDL933 961464 NP_287984.1 CDS Z6047 NC_002655.2 2308786 2309151 R DNAse encoded by cryptic prophage CP-933P complement(2308786..2309151) Escherichia coli O157:H7 str. EDL933 961465 NP_287985.1 CDS Z6048 NC_002655.2 2309193 2309420 D hypothetical protein 2309193..2309420 Escherichia coli O157:H7 str. EDL933 961467 NP_287986.1 CDS Z6049 NC_002655.2 2309783 2310250 R endopeptidase encoded by cryptic prophage CP-933U complement(2309783..2310250) Escherichia coli O157:H7 str. EDL933 961468 NP_287987.1 CDS antP NC_002655.2 2310404 2310973 R antirepressor protein encoded by cryptic prophage CP-933P complement(2310404..2310973) Escherichia coli O157:H7 str. EDL933 961470 NP_287988.1 CDS Z6051 NC_002655.2 2311244 2311777 R endolysin encoded by cryptic prophage CP-933P complement(2311244..2311777) Escherichia coli O157:H7 str. EDL933 961471 NP_287989.1 CDS Z6052 NC_002655.2 2311828 2312175 R hypothetical protein complement(2311828..2312175) Escherichia coli O157:H7 str. EDL933 961472 NP_287990.1 CDS Z6053 NC_002655.2 2312177 2312383 R holin protein encoded by cryptic prophage CP-933P complement(2312177..2312383) Escherichia coli O157:H7 str. EDL933 961475 NP_287991.1 CDS Z6054 NC_002655.2 2312832 2314682 R hypothetical protein complement(2312832..2314682) Escherichia coli O157:H7 str. EDL933 961476 NP_287992.1 CDS Z6055 NC_002655.2 2314997 2315164 R hypothetical protein complement(2314997..2315164) Escherichia coli O157:H7 str. EDL933 961477 NP_287993.1 CDS Z6056 NC_002655.2 2315161 2315580 R hypothetical protein complement(2315161..2315580) Escherichia coli O157:H7 str. EDL933 961478 NP_287994.1 CDS Z6060 NC_002655.2 2316231 2316920 R Q antiterminator encoded by prophage CP-933P complement(2316231..2316920) Escherichia coli O157:H7 str. EDL933 961483 NP_287995.1 CDS Z6061 NC_002655.2 2316917 2317276 R endonuclease encoded by cryptic prophage CP-933P complement(2316917..2317276) Escherichia coli O157:H7 str. EDL933 961485 NP_287996.1 CDS Z6062 NC_002655.2 2317289 2318338 R hypothetical protein complement(2317289..2318338) Escherichia coli O157:H7 str. EDL933 961487 NP_287997.1 CDS mokP NC_002655.2 2318786 2318998 R cell killing protein encoded within cryptic prophage CP-933P complement(2318786..2318998) Escherichia coli O157:H7 str. EDL933 961488 NP_287998.1 CDS Z6064 NC_002655.2 2319187 2319291 R No Hits; hypothetical protein complement(2319187..2319291) Escherichia coli O157:H7 str. EDL933 961489 NP_287999.1 CDS Z6065 NC_002655.2 2319407 2320051 R hypothetical protein complement(2319407..2320051) Escherichia coli O157:H7 str. EDL933 961492 NP_288000.1 CDS renP NC_002655.2 2320048 2320443 R exclusion protein ren of cryptic prophage CP-933P complement(2320048..2320443) Escherichia coli O157:H7 str. EDL933 961495 NP_288001.1 CDS Z6067 NC_002655.2 2320459 2321127 R hypothetical protein complement(2320459..2321127) Escherichia coli O157:H7 str. EDL933 961498 NP_288002.1 CDS Z6068 NC_002655.2 2321049 2321228 R hypothetical protein complement(2321049..2321228) Escherichia coli O157:H7 str. EDL933 961499 NP_288003.1 CDS Z6069 NC_002655.2 2321254 2321994 R acts to load the DnaB helicase onto the intiation site durning DNA replication; replication protein complement(2321254..2321994) Escherichia coli O157:H7 str. EDL933 961500 NP_288004.1 CDS Z6070 NC_002655.2 2322001 2322978 R hypothetical protein complement(2322001..2322978) Escherichia coli O157:H7 str. EDL933 961501 NP_288005.1 CDS Z6071 NC_002655.2 2322986 2323411 R hypothetical protein complement(2322986..2323411) Escherichia coli O157:H7 str. EDL933 961502 NP_288006.1 CDS Z6072 NC_002655.2 2323408 2323710 R hypothetical protein complement(2323408..2323710) Escherichia coli O157:H7 str. EDL933 961503 NP_288007.1 CDS Z6073 NC_002655.2 2323745 2324179 D repressor protein encoded by cryptic prophage CP-933P 2323745..2324179 Escherichia coli O157:H7 str. EDL933 961504 NP_288008.1 CDS Z6074 NC_002655.2 2324200 2324391 D hypothetical protein 2324200..2324391 Escherichia coli O157:H7 str. EDL933 961505 NP_288009.1 CDS Z6075 NC_002655.2 2324967 2325323 D hypothetical protein 2324967..2325323 Escherichia coli O157:H7 str. EDL933 961507 NP_288010.1 CDS Z6076 NC_002655.2 2325395 2325613 D hypothetical protein 2325395..2325613 Escherichia coli O157:H7 str. EDL933 961508 NP_288011.1 CDS Z6078 NC_002655.2 2326077 2326370 D inhibitor of cell division encoded by cryptic prophage CP-933P 2326077..2326370 Escherichia coli O157:H7 str. EDL933 961510 NP_288012.1 CDS Z6079 NC_002655.2 2326358 2326558 D hypothetical protein 2326358..2326558 Escherichia coli O157:H7 str. EDL933 961511 NP_288013.1 CDS exoP NC_002655.2 2326651 2329122 D exodeoxyribonuclease encoded by cryptic prophage CP-933P 2326651..2329122 Escherichia coli O157:H7 str. EDL933 961513 NP_288014.1 CDS xisP NC_002655.2 2329195 2329446 D excisionase 2329195..2329446 Escherichia coli O157:H7 str. EDL933 961514 NP_288015.1 CDS intP_1 NC_002655.2 2329466 2329636 D integrase fragment, cryptic prophage CP-933P 2329466..2329636 Escherichia coli O157:H7 str. EDL933 961518 NP_288016.1 CDS intP_2 NC_002655.2 2329684 2330172 D integrase fragment, cryptic prophage CP-933P 2329684..2330172 Escherichia coli O157:H7 str. EDL933 961519 NP_288017.1 CDS Z2569 NC_002655.2 2330435 2330761 R hypothetical protein complement(2330435..2330761) Escherichia coli O157:H7 str. EDL933 961520 NP_288018.1 CDS Z2570 NC_002655.2 2330896 2331237 D hypothetical protein 2330896..2331237 Escherichia coli O157:H7 str. EDL933 961523 NP_288019.1 CDS speG NC_002655.2 2331272 2331832 D spermidine N1-acetyltransferase 2331272..2331832 Escherichia coli O157:H7 str. EDL933 961524 NP_288020.2 CDS ynfC NC_002655.2 2331835 2332545 R hypothetical protein complement(2331835..2332545) Escherichia coli O157:H7 str. EDL933 961525 NP_288021.1 CDS Z2573 NC_002655.2 2332650 2332958 D hypothetical protein 2332650..2332958 Escherichia coli O157:H7 str. EDL933 961526 NP_288022.1 CDS Z2575 NC_002655.2 2333157 2335583 D oxidoreductase, major subunit 2333157..2335583 Escherichia coli O157:H7 str. EDL933 961527 NP_288023.1 CDS Z2576 NC_002655.2 2335641 2338067 D oxidoreductase, major subunit 2335641..2338067 Escherichia coli O157:H7 str. EDL933 961528 NP_288024.1 CDS Z2577 NC_002655.2 2338078 2338695 D oxidoreductase, Fe-S subunit 2338078..2338695 Escherichia coli O157:H7 str. EDL933 961529 NP_288025.1 CDS Z2579 NC_002655.2 2338697 2339551 D DMSO reductase anchor subunit 2338697..2339551 Escherichia coli O157:H7 str. EDL933 961530 NP_288026.2 CDS Z2581 NC_002655.2 2339594 2340208 D binds to the twin-arginine signal peptides of certain proteins, including dimethylsulfoxide reductase and trimethylamine N-oxide reductase that are translocated to the cytoplasmic membrane; twin-argninine leader-binding protein DmsD 2339594..2340208 Escherichia coli O157:H7 str. EDL933 961535 NP_288027.2 CDS Z2583 NC_002655.2 2340402 2341658 D voltage-gated ClC-type chloride channel ClcB 2340402..2341658 Escherichia coli O157:H7 str. EDL933 961537 NP_288028.2 CDS bioD NC_002655.2 2341611 2342306 R DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase complement(2341611..2342306) Escherichia coli O157:H7 str. EDL933 961539 NP_288029.1 CDS mlc NC_002655.2 2342431 2343651 R NAGC-like transcriptional regulator complement(2342431..2343651) Escherichia coli O157:H7 str. EDL933 961540 NP_288030.1 CDS ynfL NC_002655.2 2343786 2344679 R LysR family transcriptional regulator complement(2343786..2344679) Escherichia coli O157:H7 str. EDL933 961542 NP_288031.1 CDS ynfM NC_002655.2 2344786 2346039 D transporter 2344786..2346039 Escherichia coli O157:H7 str. EDL933 961543 NP_288032.2 CDS asr NC_002655.2 2346463 2346771 D required for growth and survival under moderately acid conditions; acid shock protein 2346463..2346771 Escherichia coli O157:H7 str. EDL933 961544 NP_288033.1 CDS Z2592 NC_002655.2 2347047 2347868 D hypothetical protein 2347047..2347868 Escherichia coli O157:H7 str. EDL933 961545 NP_288034.1 CDS Z2593 NC_002655.2 2347907 2348236 R with MdtJ is involved in resistance to deoxycholate, nalidixic acid, fosfomycin, and SDS; multidrug efflux system protein MdtI complement(2347907..2348236) Escherichia coli O157:H7 str. EDL933 961546 NP_288035.1 CDS Z2594 NC_002655.2 2348223 2348588 R with MdtI is involved in resistance to deoxycholate , nalidixic acid, fosfomycin, and SDS; multidrug efflux system protein MdtJ complement(2348223..2348588) Escherichia coli O157:H7 str. EDL933 961548 NP_288036.1 CDS tqsA NC_002655.2 2349000 2350034 D transport of quorum-sensing signal; mutations in this gene alters the transport of the quorum-sensing signal autoinducer 2 (AI-2) which affects expression of a large number of genes; transporter 2349000..2350034 Escherichia coli O157:H7 str. EDL933 961549 NP_288037.1 CDS pntB NC_002655.2 2350059 2351447 R catalyzes reversible transfer of hydride ion equivalent between NAD and NADP; membrane-bound proton pump that translocates protons from cytosolic to periplasmic side of the inner membrane; forms a tetramer composed of two alpha and 2 beta subunits; AB-stereospecific enzyme; pyridine nucleotide transhydrogenase complement(2350059..2351447) Escherichia coli O157:H7 str. EDL933 961550 NP_288038.1 CDS pntA NC_002655.2 2351458 2352990 R forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane; involved in catalyzing transfer of hydride ion equivalents between NAD and NADP; stereospecific (AB-specific); functions as a proton pump by translocating protons from cytoplasm to periplasm; NAD(P) transhydrogenase subunit alpha complement(2351458..2352990) Escherichia coli O157:H7 str. EDL933 961551 NP_288039.1 CDS Z2603 NC_002655.2 2353514 2354458 D hypothetical protein 2353514..2354458 Escherichia coli O157:H7 str. EDL933 961552 NP_288040.1 CDS Z2605 NC_002655.2 2354644 2356026 D arginine/ornithine antiporter 2354644..2356026 Escherichia coli O157:H7 str. EDL933 961554 NP_288041.1 CDS ydgB NC_002655.2 2356063 2356785 D short chain dehydrogenase 2356063..2356785 Escherichia coli O157:H7 str. EDL933 961555 NP_288042.1 CDS ydgC NC_002655.2 2356782 2357117 R hypothetical protein complement(2356782..2357117) Escherichia coli O157:H7 str. EDL933 961556 NP_288043.1 CDS rstA NC_002655.2 2357237 2357965 D response regulator in two-component regulatory system with RstB; DNA-binding transcriptional regulator RstA 2357237..2357965 Escherichia coli O157:H7 str. EDL933 961557 NP_288044.1 CDS rstB NC_002655.2 2357969 2359270 D sensor protein RstB 2357969..2359270 Escherichia coli O157:H7 str. EDL933 961558 NP_288045.1 CDS tus NC_002655.2 2359347 2360276 D binds to DNA replication terminator sequences to prevent passage of replication forks; DNA replication terminus site-binding protein 2359347..2360276 Escherichia coli O157:H7 str. EDL933 961559 NP_288046.1 CDS fumC NC_002655.2 2360273 2361676 R class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase complement(2360273..2361676) Escherichia coli O157:H7 str. EDL933 961561 NP_288047.1 CDS fumA NC_002655.2 2361819 2363465 R fumarase A complement(2361819..2363465) Escherichia coli O157:H7 str. EDL933 961562 NP_288048.1 CDS manA NC_002655.2 2363664 2364839 D mannose-6-phosphate isomerase 2363664..2364839 Escherichia coli O157:H7 str. EDL933 961563 NP_288049.1 CDS ydgA NC_002655.2 2364940 2366448 D hypothetical protein 2364940..2366448 Escherichia coli O157:H7 str. EDL933 961564 NP_288050.1 CDS Z2618 NC_002655.2 2366493 2366714 R hypothetical protein complement(2366493..2366714) Escherichia coli O157:H7 str. EDL933 961565 NP_288051.1 CDS Z2619 NC_002655.2 2366729 2367757 R hypothetical protein complement(2366729..2367757) Escherichia coli O157:H7 str. EDL933 961566 NP_288052.1 CDS uidB NC_002655.2 2367796 2369169 R glucuronide transporter complement(2367796..2369169) Escherichia coli O157:H7 str. EDL933 961567 NP_288053.1 CDS uidA NC_002655.2 2369166 2370979 R beta-D-glucuronidase complement(join(2369166..2370296,2370296..2370979)) Escherichia coli O157:H7 str. EDL933 959631 NP_288054.1 CDS uidR NC_002655.2 2371370 2371960 R repressor for uid operon complement(2371370..2371960) Escherichia coli O157:H7 str. EDL933 961568 NP_288055.1 CDS hdhA NC_002655.2 2372189 2372956 R Acts on the hydroxyl group at position 7 of the steroid frame; 7-alpha-hydroxysteroid dehydrogenase complement(2372189..2372956) Escherichia coli O157:H7 str. EDL933 961569 NP_288056.1 CDS malI NC_002655.2 2373068 2374096 R regulates malXY which are involved in maltose-glucose transport; DNA-binding transcriptional repressor MalI complement(2373068..2374096) Escherichia coli O157:H7 str. EDL933 961570 NP_288057.1 CDS malX NC_002655.2 2374271 2375863 D phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS); catalyzes the phosphorylation of maltose and glucose concomitant with their translocation across the cell membrane; component IIB catalyzes the phosphorylation of the sugar molecule; IIC forms the translocation channel and contains the substrate specific binding site; bifunctional PTS system maltose and glucose-specific transporter subunits IICB 2374271..2375863 Escherichia coli O157:H7 str. EDL933 961571 NP_288058.1 CDS malY NC_002655.2 2375873 2377045 D hypothetical protein 2375873..2377045 Escherichia coli O157:H7 str. EDL933 961572 NP_288059.1 CDS add NC_002655.2 2377149 2378150 D catalyzes the formation of inosine from adenosine; adenosine deaminase 2377149..2378150 Escherichia coli O157:H7 str. EDL933 961573 NP_288060.2 CDS Z2629 NC_002655.2 2378186 2379226 R oxidoreductase complement(2378186..2379226) Escherichia coli O157:H7 str. EDL933 961574 NP_288061.1 CDS Z2631 NC_002655.2 2379868 2380083 D YdgT; in E. coli, when complexed with H-NS or StpA binds a 26 base-pair DNA sequence of oriC; seems to play a role in optimizing the activity of oriC; non-essential; Hha protein paralog; in an hha mutant background, cnu is overexpressed and can compensate hha-induced phenotypes; oriC-binding nucleoid-associated protein 2379868..2380083 Escherichia coli O157:H7 str. EDL933 961575 NP_288062.1 CDS Z2632 NC_002655.2 2380145 2380609 D hypothetical protein 2380145..2380609 Escherichia coli O157:H7 str. EDL933 961576 NP_288063.1 CDS Z2633 NC_002655.2 2380686 2381267 D Na(+)-translocating NADH-quinone reductase subunit E 2380686..2381267 Escherichia coli O157:H7 str. EDL933 961577 NP_288064.1 CDS Z2634 NC_002655.2 2381267 2381845 D part of membrane-bound complex thought to be involved in electron transport to nitrogen; electron transport complex protein RnfB 2381267..2381845 Escherichia coli O157:H7 str. EDL933 961578 NP_288065.1 CDS Z2636 NC_002655.2 2381838 2384060 D part of membrane-bound complex thought to be involved in electron transport to nitrogen; electron transport complex protein RnfC 2381838..2384060 Escherichia coli O157:H7 str. EDL933 961579 NP_288066.1 CDS rnfD NC_002655.2 2384061 2385119 D RnfD; RsxD; required for nitrogen fixation in Rhodobacter capsulatus; part of a membrane-bound complex thought to be involved in electron transport to nitrogenase; in Escherichia coli this gene is part of a cluster controlling SoxR-mediated induction of the SoxS transcription factor in the absence of oxidizing agents; electron transport complex protein RnfD 2384061..2385119 Escherichia coli O157:H7 str. EDL933 961580 NP_288067.1 CDS Z2640 NC_002655.2 2385123 2385743 D part of membrane-bound complex hought to be involved in electron transport to nitrogen; electron transport complex protein RnfG 2385123..2385743 Escherichia coli O157:H7 str. EDL933 961583 NP_288068.1 CDS ydgQ NC_002655.2 2385747 2386442 D in Excherichia coli RsxABCDEG reduces SoxR which turns off induction of SoxS transcription factor in the absence of oxidizing agents; similar to the rnfABCDGE operon in Rhodobacter capsulatus involved in transferring electrons to nitrogenase; electron transport complex protein RsxE 2385747..2386442 Escherichia coli O157:H7 str. EDL933 961584 NP_288069.1 CDS nth NC_002655.2 2386442 2387077 D DNA-(apurinic or apyrimidinic site) lyase; has apurinic or apyrimidinic endonuclease activity and DNA N-glycosylase activity; removed damaged DNA at cytosines, thymines and guanines; endonuclease III 2386442..2387077 Escherichia coli O157:H7 str. EDL933 961585 NP_288070.1 CDS tppB NC_002655.2 2387688 2389190 D mutations in this gene confer resistance to the toxic peptide alafosfalin in Salmonella typhimurium; member of proton-dependent oligopeptide transport (POT) system family; in Escherichia coli this gene is regulated by OmpR although not via osmoregulation; tripeptide transporter permease 2387688..2389190 Escherichia coli O157:H7 str. EDL933 961587 NP_288071.1 CDS gst NC_002655.2 2389296 2389901 D glutathionine S-transferase 2389296..2389901 Escherichia coli O157:H7 str. EDL933 961588 NP_288072.1 CDS pdxY NC_002655.2 2389945 2390808 R catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal; pyridoxamine kinase complement(2389945..2390808) Escherichia coli O157:H7 str. EDL933 961591 NP_288073.1 CDS tyrS NC_002655.2 2390867 2392153 R catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase complement(2390867..2392153) Escherichia coli O157:H7 str. EDL933 961592 NP_288074.1 CDS pdxH NC_002655.2 2392271 2392927 R catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate; pyridoxamine 5'-phosphate oxidase complement(2392271..2392927) Escherichia coli O157:H7 str. EDL933 961593 NP_288075.1 CDS ydhA NC_002655.2 2392986 2393234 R hypothetical protein complement(2392986..2393234) Escherichia coli O157:H7 str. EDL933 961594 NP_288076.1 CDS anmK NC_002655.2 2393413 2394522 R catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling; anhydro-N-acetylmuramic acid kinase complement(2393413..2394522) Escherichia coli O157:H7 str. EDL933 961598 NP_288077.1 CDS slyB NC_002655.2 2394796 2395263 D hypothetical protein 2394796..2395263 Escherichia coli O157:H7 str. EDL933 961599 NP_288078.2 CDS slyA NC_002655.2 2395310 2395744 R Transcription regulator that can both activate or repress expression; transcriptional regulator SlyA complement(2395310..2395744) Escherichia coli O157:H7 str. EDL933 961601 NP_288079.1 CDS Z2658 NC_002655.2 2395945 2396181 D hypothetical protein 2395945..2396181 Escherichia coli O157:H7 str. EDL933 961602 NP_288080.1 CDS Z2659 NC_002655.2 2396142 2397041 D hypothetical protein 2396142..2397041 Escherichia coli O157:H7 str. EDL933 961603 NP_288081.1 CDS Z2660 NC_002655.2 2397041 2399053 D hypothetical protein 2397041..2399053 Escherichia coli O157:H7 str. EDL933 961604 NP_288082.1 CDS sodC NC_002655.2 2399054 2399575 R SodC; copper and zinc binding; converts superoxide radicals to hydrogen peroxide and water; superoxide dismutase complement(2399054..2399575) Escherichia coli O157:H7 str. EDL933 961605 NP_288083.1 CDS Z2664 NC_002655.2 2399764 2400552 R hypothetical protein complement(2399764..2400552) Escherichia coli O157:H7 str. EDL933 961607 NP_288084.1 CDS Z2665 NC_002655.2 2400601 2400978 R hypothetical protein complement(2400601..2400978) Escherichia coli O157:H7 str. EDL933 961609 NP_288085.1 CDS Z2666 NC_002655.2 2400943 2401542 D hypothetical protein 2400943..2401542 Escherichia coli O157:H7 str. EDL933 961610 NP_288086.1 CDS nemA NC_002655.2 2401579 2402676 D FMN-linked; catalyzes the formation of N-ethylsuccinimide from N-ethylmaleimide; N-ethylmaleimide reductase 2401579..2402676 Escherichia coli O157:H7 str. EDL933 961612 NP_288087.1 CDS gloA NC_002655.2 2402757 2403164 D Ni-dependent; catalyzes the formation of S-lactoylglutathione from methylglyoxal and glutathione; glyoxalase I 2402757..2403164 Escherichia coli O157:H7 str. EDL933 961613 NP_288088.1 CDS rnt NC_002655.2 2403267 2403914 D Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A); ribonuclease T 2403267..2403914 Escherichia coli O157:H7 str. EDL933 961614 NP_288089.1 CDS lhr NC_002655.2 2404007 2408623 D similar to the DNA and RNA helicase superfamily II and eukaryotic DEAD family of helicases; longest known protein in E. coli; ATP-dependent helicase Lhr 2404007..2408623 Escherichia coli O157:H7 str. EDL933 961615 NP_288090.1 CDS ydhD NC_002655.2 2408674 2409021 R hypothetical protein complement(2408674..2409021) Escherichia coli O157:H7 str. EDL933 961616 NP_288091.1 CDS ydhO NC_002655.2 2409356 2410171 D lipoprotein 2409356..2410171 Escherichia coli O157:H7 str. EDL933 961617 NP_288092.1 CDS sodB NC_002655.2 2410299 2410880 D SodB; iron binding; present under aerobic and anaerobic conditions; destroys free radicals; superoxide dismutase 2410299..2410880 Escherichia coli O157:H7 str. EDL933 961618 NP_288093.1 CDS Z2679 NC_002655.2 2411026 2412195 R transporter complement(2411026..2412195) Escherichia coli O157:H7 str. EDL933 961620 NP_288094.1 CDS purR NC_002655.2 2412749 2413774 D binds to the purF operator and coregulates other genes for de novo purine nucleotide synthesis; is involved in regulation of purB, purC, purEK, purHD, purL, purMN and guaBA expression; binds hypoxanthine and guanine as inducers; DNA-binding transcriptional repressor PurR 2412749..2413774 Escherichia coli O157:H7 str. EDL933 961621 NP_288095.1 CDS ydhB NC_002655.2 2413771 2414703 R DNA-binding transcriptional regulator complement(2413771..2414703) Escherichia coli O157:H7 str. EDL933 961628 NP_288096.1 CDS ydhC NC_002655.2 2414816 2416027 D uncharacterized member of the major facilitator superfamily (MFS); inner membrane transport protein YdhC 2414816..2416027 Escherichia coli O157:H7 str. EDL933 961629 NP_288097.1 CDS cfa NC_002655.2 2416318 2417466 D catalyzes the transfer of a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge; cyclopropane-fatty-acyl-phospholipid synthase 2416318..2417466 Escherichia coli O157:H7 str. EDL933 961630 NP_288098.1 CDS ribE NC_002655.2 2417506 2418147 R catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha complement(2417506..2418147) Escherichia coli O157:H7 str. EDL933 961631 NP_288099.1 CDS ydhE NC_002655.2 2418364 2419737 D NorM; MdtK; functions as a Na(+)/drug antiporter; inactivation in Vibrio cholerae results in susceptibility to fluoroquinolones; multidrug efflux protein 2418364..2419737 Escherichia coli O157:H7 str. EDL933 961632 NP_288100.1 CDS Z2691 NC_002655.2 2419778 2421034 R hypothetical protein complement(2419778..2421034) Escherichia coli O157:H7 str. EDL933 961633 NP_288101.1 CDS Z2694 NC_002655.2 2421607 2421912 D hypothetical protein 2421607..2421912 Escherichia coli O157:H7 str. EDL933 961637 NP_288102.1 CDS Z2695 NC_002655.2 2422038 2423642 D hypothetical protein 2422038..2423642 Escherichia coli O157:H7 str. EDL933 961638 NP_288103.1 CDS Z2696 NC_002655.2 2423654 2424466 R hypothetical protein complement(2423654..2424466) Escherichia coli O157:H7 str. EDL933 961640 NP_288104.1 CDS ydhU NC_002655.2 2424470 2425255 R hypothetical protein complement(2424470..2425255) Escherichia coli O157:H7 str. EDL933 961641 NP_288105.1 CDS Z2698 NC_002655.2 2425252 2425971 R oxidoreductase, Fe-S subunit complement(2425252..2425971) Escherichia coli O157:H7 str. EDL933 961642 NP_288106.1 CDS Z2700 NC_002655.2 2425984 2426631 R hypothetical protein complement(2425984..2426631) Escherichia coli O157:H7 str. EDL933 961643 NP_288107.1 CDS Z2701 NC_002655.2 2426635 2428737 R oxidoreductase complement(2426635..2428737) Escherichia coli O157:H7 str. EDL933 961644 NP_288108.1 CDS Z2702 NC_002655.2 2428758 2429384 R hypothetical protein complement(2428758..2429384) Escherichia coli O157:H7 str. EDL933 961645 NP_288109.1 CDS Z2703 NC_002655.2 2429840 2430049 R hypothetical protein complement(2429840..2430049) Escherichia coli O157:H7 str. EDL933 961646 NP_288110.1 CDS pykF NC_002655.2 2430606 2432018 D catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 2430606..2432018 Escherichia coli O157:H7 str. EDL933 961647 NP_288111.1 CDS lpp NC_002655.2 2432329 2432565 D murein lipoprotein 2432329..2432565 Escherichia coli O157:H7 str. EDL933 961648 NP_288112.1 CDS ynhG NC_002655.2 2432628 2433632 R hypothetical protein complement(2432628..2433632) Escherichia coli O157:H7 str. EDL933 961649 NP_288113.1 CDS ynhA NC_002655.2 2433781 2434197 R Acts with SufS to catalyze the formation of L-alanine from L-cysteine; cysteine desufuration protein SufE complement(2433781..2434197) Escherichia coli O157:H7 str. EDL933 961650 NP_288114.1 CDS Z2708 NC_002655.2 2434210 2435430 R catalyzes the formation of L-alanine and selenide or sulfanylcysteine from selenocysteine or cysteine; bifunctional cysteine desulfurase/selenocysteine lyase complement(2434210..2435430) Escherichia coli O157:H7 str. EDL933 961651 NP_288115.1 CDS ynhC NC_002655.2 2435427 2436698 R with SufBC activates cysteine desulfurase SufS; cysteine desulfurase complement(2435427..2436698) Escherichia coli O157:H7 str. EDL933 961652 NP_288116.1 CDS sufC NC_002655.2 2436673 2437419 R part of SUF system involved in inserting iron-sulfur clusters into proteins; in Escherichia coli this protein forms a complex with SufBD; the SufBCD complex stimulates the cysteine desulfurase SufS in conjunction with SufE; cysteine desulfurase complement(2436673..2437419) Escherichia coli O157:H7 str. EDL933 961653 NP_288117.1 CDS ynhE NC_002655.2 2437429 2438955 R with SufCD activates cysteine desulfurase SufS; cysteine desulfurase complement(2437429..2438955) Escherichia coli O157:H7 str. EDL933 961654 NP_288118.1 CDS sufA NC_002655.2 2438925 2439293 R functions as a scaffold on which iron-sulfur clusters ([2Fe-2S]; [4Fe-4S]) are assembled; forms a homodimer; similar to IscA protein; iron-sulfur cluster assembly scaffold protein complement(2438925..2439293) Escherichia coli O157:H7 str. EDL933 961655 NP_288119.1 CDS Z2713 NC_002655.2 2439842 2440111 R hypothetical protein complement(2439842..2440111) Escherichia coli O157:H7 str. EDL933 961656 NP_288120.1 CDS Z2714 NC_002655.2 2440130 2440540 R hypothetical protein complement(2440130..2440540) Escherichia coli O157:H7 str. EDL933 961657 NP_288121.1 CDS ydiJ NC_002655.2 2440537 2443593 R oxidase complement(2440537..2443593) Escherichia coli O157:H7 str. EDL933 961658 NP_288122.1 CDS Z2716 NC_002655.2 2443982 2445094 D YdiK; inner membrane protein; ydiK promoter presents a PurR sequence, suggesting that its expression is purine-regulated; unknown function; hypothetical protein 2443982..2445094 Escherichia coli O157:H7 str. EDL933 961659 NP_288123.1 CDS Z2717 NC_002655.2 2445496 2445879 D hypothetical protein 2445496..2445879 Escherichia coli O157:H7 str. EDL933 961660 NP_288124.1 CDS Z2718 NC_002655.2 2445979 2447193 D transport system permease 2445979..2447193 Escherichia coli O157:H7 str. EDL933 961661 NP_288125.1 CDS Z2719 NC_002655.2 2447414 2448685 D amino acid/amine transport protein 2447414..2448685 Escherichia coli O157:H7 str. EDL933 961662 NP_288126.1 CDS aroE NC_002655.2 2448697 2449563 D YdiB; quinate/shikimate dehydrogenase from Escherichia coli uses both NAD and NAD(P) to convert quinate and shikimate to 3-dehydroquinate and 3-dehydroshikimate; quinate/shikimate dehydrogenase 2448697..2449563 Escherichia coli O157:H7 str. EDL933 961663 NP_288127.1 CDS aroD NC_002655.2 2449594 2450352 D catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis; 3-dehydroquinate dehydratase 2449594..2450352 Escherichia coli O157:H7 str. EDL933 961664 NP_288128.1 CDS ydiF NC_002655.2 2450497 2452092 D hypothetical protein 2450497..2452092 Escherichia coli O157:H7 str. EDL933 961665 NP_288129.2 CDS Z2723 NC_002655.2 2452106 2453257 D may play a role in electron transport between the anaerobic fatty acid oxidation pathway and the respiratory chain; acyl-CoA dehydrogenase 2452106..2453257 Escherichia coli O157:H7 str. EDL933 961666 NP_288130.1 CDS Z2724 NC_002655.2 2453300 2454211 R AraC family transcriptional regulator complement(2453300..2454211) Escherichia coli O157:H7 str. EDL933 961667 NP_288131.1 CDS ydiQ NC_002655.2 2454532 2455296 D YdiO, YdiQ, YdiR, YdiS, and YdiT may play a role in electron transport between the anaerobic fatty acid oxidation pathway and the respiratory chain; electron transfer flavoprotein YdiQ 2454532..2455296 Escherichia coli O157:H7 str. EDL933 961668 NP_288132.1 CDS ydiR NC_002655.2 2455316 2456254 D May play a role in a redox process; electron transfer flavoprotein subunit YdiR 2455316..2456254 Escherichia coli O157:H7 str. EDL933 961669 NP_288133.1 CDS ydiS NC_002655.2 2456310 2457599 D hypothetical protein 2456310..2457599 Escherichia coli O157:H7 str. EDL933 961670 NP_288134.1 CDS ydiT NC_002655.2 2457596 2457889 D hypothetical protein 2457596..2457889 Escherichia coli O157:H7 str. EDL933 961671 NP_288135.1 CDS ydiD NC_002655.2 2457892 2459592 D acts in anaerobic beta-oxidation of fatty acids; possible ligase/synthase involved in anaerobic growth on fatty acids; short chain acyl-CoA synthetase 2457892..2459592 Escherichia coli O157:H7 str. EDL933 961672 NP_288136.1 CDS ppsA NC_002655.2 2459649 2462027 R catalyzes the formation of phosphoenolpyruvate from pyruvate; phosphoenolpyruvate synthase complement(2459649..2462027) Escherichia coli O157:H7 str. EDL933 961673 NP_288137.1 CDS ydiA NC_002655.2 2462360 2463193 D hypothetical protein 2462360..2463193 Escherichia coli O157:H7 str. EDL933 961674 NP_288138.1 CDS aroH NC_002655.2 2463350 2464396 D tryptophan sensitive; catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate; phospho-2-dehydro-3-deoxyheptonate aldolase 2463350..2464396 Escherichia coli O157:H7 str. EDL933 961675 NP_288139.1 CDS ydiE NC_002655.2 2464528 2464719 D hypothetical protein 2464528..2464719 Escherichia coli O157:H7 str. EDL933 961676 NP_288140.1 CDS Z2735 NC_002655.2 2464723 2466159 R hypothetical protein complement(2464723..2466159) Escherichia coli O157:H7 str. EDL933 961677 NP_288141.1 CDS Z2736 NC_002655.2 2466222 2466935 R hypothetical protein complement(2466222..2466935) Escherichia coli O157:H7 str. EDL933 961678 NP_288142.1 CDS nlpC NC_002655.2 2467182 2467646 R lipoprotein complement(2467182..2467646) Escherichia coli O157:H7 str. EDL933 961679 NP_288143.1 CDS btuD NC_002655.2 2467724 2468473 R ATP-binding protein that acts with the transmembrane protein BtuC and the solute binding protein BtuF to transport vitamin B12 into the cell; vitamin B12-transporter ATPase complement(2467724..2468473) Escherichia coli O157:H7 str. EDL933 961680 NP_288144.1 CDS btuE NC_002655.2 2468473 2469024 R similar to glutathione peroxidase; member of the btuCED operon which is required for vitamin B12 transport across the inner membrane; glutathione peroxidase complement(2468473..2469024) Escherichia coli O157:H7 str. EDL933 961681 NP_288145.1 CDS btuC NC_002655.2 2469087 2470067 R with BtuD and BtuF transports vitamin B12 into the cell; vtamin B12-transporter permease complement(2469087..2470067) Escherichia coli O157:H7 str. EDL933 961682 NP_288146.1 CDS ihfA NC_002655.2 2470169 2470468 R This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit alpha complement(2470169..2470468) Escherichia coli O157:H7 str. EDL933 961683 NP_288147.1 CDS pheT NC_002655.2 2470473 2472860 R catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta complement(2470473..2472860) Escherichia coli O157:H7 str. EDL933 961684 NP_288148.1 CDS pheS NC_002655.2 2472875 2473858 R catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha complement(2472875..2473858) Escherichia coli O157:H7 str. EDL933 961685 NP_288150.1 CDS rplT NC_002655.2 2474308 2474664 R binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 complement(2474308..2474664) Escherichia coli O157:H7 str. EDL933 961687 NP_288151.1 CDS rpmI NC_002655.2 2474717 2474914 R 50S ribosomal protein L35 complement(2474717..2474914) Escherichia coli O157:H7 str. EDL933 961688 NP_288152.1 CDS infC NC_002655.2 2475011 2475445 R IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits; translation initiation factor IF-3 complement(2475011..2475445) Escherichia coli O157:H7 str. EDL933 961689 NP_288153.1 CDS thrS NC_002655.2 2475557 2477485 R catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; threonyl-tRNA synthetase complement(2475557..2477485) Escherichia coli O157:H7 str. EDL933 961690 NP_288154.1 CDS Z2749 NC_002655.2 2478008 2479906 D hypothetical protein 2478008..2479906 Escherichia coli O157:H7 str. EDL933 961691 NP_288155.1 CDS Z2751 NC_002655.2 2480241 2480999 R hypothetical protein complement(2480241..2480999) Escherichia coli O157:H7 str. EDL933 961692 NP_288156.1 CDS pfkB NC_002655.2 2481286 2482215 D 6-phosphofructokinase 2481286..2482215 Escherichia coli O157:H7 str. EDL933 961693 NP_288157.1 CDS Z2753 NC_002655.2 2482316 2482606 D hypothetical protein 2482316..2482606 Escherichia coli O157:H7 str. EDL933 961694 NP_288158.1 CDS Z2754 NC_002655.2 2482712 2483572 D hypothetical protein 2482712..2483572 Escherichia coli O157:H7 str. EDL933 961695 NP_288159.1 CDS Z2755 NC_002655.2 2483613 2484149 R hypothetical protein complement(2483613..2484149) Escherichia coli O157:H7 str. EDL933 961696 NP_288160.1 CDS Z2756 NC_002655.2 2484296 2484964 D YniC; catalyzes the dephosphorylation of 2-deoxyglucose 6-phosphate, mannose 6-phosphate and p-nitrophenyl phosphate; 2-deoxyglucose-6-phosphatase 2484296..2484964 Escherichia coli O157:H7 str. EDL933 961697 NP_288161.2 CDS Z2757 NC_002655.2 2485127 2485717 D hypothetical protein 2485127..2485717 Escherichia coli O157:H7 str. EDL933 961698 NP_288162.1 CDS Z2758 NC_002655.2 2485850 2487241 D hypothetical protein 2485850..2487241 Escherichia coli O157:H7 str. EDL933 961699 NP_288163.1 CDS Z2759 NC_002655.2 2487292 2488047 R hypothetical protein complement(2487292..2488047) Escherichia coli O157:H7 str. EDL933 961700 NP_288164.1 CDS Z2760 NC_002655.2 2488336 2488599 R cell division modulator complement(2488336..2488599) Escherichia coli O157:H7 str. EDL933 961701 NP_288165.1 CDS katE NC_002655.2 2488782 2491043 D Catalase HPII; monofunctional catalase that decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide; hydroperoxidase II 2488782..2491043 Escherichia coli O157:H7 str. EDL933 961702 NP_288166.1 CDS ydjC NC_002655.2 2491090 2491848 R hypothetical protein complement(2491090..2491848) Escherichia coli O157:H7 str. EDL933 961703 NP_288167.1 CDS celF NC_002655.2 2491861 2493213 R 6-phospho-beta-glucosidase complement(2491861..2493213) Escherichia coli O157:H7 str. EDL933 961704 NP_288168.1 CDS celD NC_002655.2 2493319 2494161 R represses the celABCDF-ydjC operon involved in carbon uptake; DNA-binding transcriptional regulator ChbR complement(2493319..2494161) Escherichia coli O157:H7 str. EDL933 961705 NP_288169.1 CDS celC NC_002655.2 2494169 2494519 R catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system N,N'-diacetylchitobiose-specific transporter subunit IIA complement(2494169..2494519) Escherichia coli O157:H7 str. EDL933 961706 NP_288170.1 CDS celB NC_002655.2 2494570 2495928 R catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC complement(2494570..2495928) Escherichia coli O157:H7 str. EDL933 961707 NP_288171.1 CDS celA NC_002655.2 2496013 2496333 R catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system N,N'-diacetylchitobiose-specific transporter subunit IIB complement(2496013..2496333) Escherichia coli O157:H7 str. EDL933 961708 NP_288172.1 CDS osmE NC_002655.2 2496633 2496971 R osmotically-inducible lipoprotein E; activator of ntr-like gene protein; DNA-binding transcriptional activator OsmE complement(2496633..2496971) Escherichia coli O157:H7 str. EDL933 961709 NP_288173.1 CDS nadE NC_002655.2 2497173 2498000 D catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers; NAD synthetase 2497173..2498000 Escherichia coli O157:H7 str. EDL933 961710 NP_288174.1 CDS Z2771 NC_002655.2 2498230 2499117 D 3' incision activity; acts with UvrC; nucleotide excision repair endonuclease 2498230..2499117 Escherichia coli O157:H7 str. EDL933 961711 NP_288175.1 CDS Z2774 NC_002655.2 2499077 2499715 R hypothetical protein complement(2499077..2499715) Escherichia coli O157:H7 str. EDL933 961712 NP_288176.1 CDS spy NC_002655.2 2499855 2500340 R periplasmic protein induced by stress response via Cpx and BaeSR system; similar to CpxP; hypothetical protein complement(2499855..2500340) Escherichia coli O157:H7 str. EDL933 961713 NP_288177.1 CDS ydjS NC_002655.2 2500670 2501638 R catalyzes the formation of succinate and glutamate from N(2)-succinylglutamate in arginine catabolism; succinylglutamate desuccinylase complement(2500670..2501638) Escherichia coli O157:H7 str. EDL933 961715 NP_288178.1 CDS Z2777 NC_002655.2 2501631 2502974 R catalyzes the hydrolysis of 2-N-succinylarginine into 2-N-succinylornithine, ammonia and carbon dioxide in arginine degradation; succinylarginine dihydrolase complement(2501631..2502974) Escherichia coli O157:H7 str. EDL933 961716 NP_288179.1 CDS astD NC_002655.2 2502971 2504449 R a high throughput screen identified this enzyme as an aldehyde dehydrogenase with broad substrate specificity; converts succinylglutamate semialdehyde and NAD to succinylglutamate and NADH; succinylglutamic semialdehyde dehydrogenase complement(2502971..2504449) Escherichia coli O157:H7 str. EDL933 961717 NP_288180.1 CDS Z2779 NC_002655.2 2504446 2505480 R arginine succinyltransferase complement(2504446..2505480) Escherichia coli O157:H7 str. EDL933 961718 NP_288181.1 CDS argD NC_002655.2 2505477 2506697 R catalyzes the transamination of 2-N-succinylornithine and alpha-ketoglutarate into 2-N-succinylglutamate semialdehyde and glutamate; also functions as the catabolic acetylornithine aminotransferase catalyzing the formation of 2-N-acetylglutamate semialdehyde and glutamate from 2-N-acetylornithine and alpha-ketoglutarate; bifunctional succinylornithine transaminase/acetylornithine transaminase complement(2505477..2506697) Escherichia coli O157:H7 str. EDL933 961719 NP_288182.1 CDS xthA NC_002655.2 2507143 2507949 D removes the damaged DNA at cytosines and guanines by cleaving on the 3' side of the AP site by a beta-elimination reaction; exonuclease III 2507143..2507949 Escherichia coli O157:H7 str. EDL933 961720 NP_288183.1 CDS ydjX NC_002655.2 2508068 2508826 D hypothetical protein 2508068..2508826 Escherichia coli O157:H7 str. EDL933 961721 NP_288184.1 CDS ydjY NC_002655.2 2508669 2509508 D hypothetical protein 2508669..2509508 Escherichia coli O157:H7 str. EDL933 961722 NP_288185.1 CDS ydjZ NC_002655.2 2509523 2510230 D hypothetical protein 2509523..2510230 Escherichia coli O157:H7 str. EDL933 961723 NP_288186.1 CDS ynjA NC_002655.2 2510230 2510778 D hypothetical protein 2510230..2510778 Escherichia coli O157:H7 str. EDL933 961724 NP_288187.1 CDS Z2786 NC_002655.2 2510785 2511954 D ABC transporter substrate-binding protein 2510785..2511954 Escherichia coli O157:H7 str. EDL933 961725 NP_288188.1 CDS Z2787 NC_002655.2 2511972 2513462 D transport system permease 2511972..2513462 Escherichia coli O157:H7 str. EDL933 961726 NP_288189.1 CDS Z2788 NC_002655.2 2513462 2514115 D ABC transporter ATP-binding protein 2513462..2514115 Escherichia coli O157:H7 str. EDL933 961727 NP_288190.1 CDS Z2789 NC_002655.2 2514167 2515489 D thiosulfate sulfurtransferase 2514167..2515489 Escherichia coli O157:H7 str. EDL933 961728 NP_288191.1 CDS Z2790 NC_002655.2 2515498 2516124 R cytochrome oxidase complement(2515498..2516124) Escherichia coli O157:H7 str. EDL933 961729 NP_288192.1 CDS Z2791 NC_002655.2 2516205 2516612 D pyrimidine (deoxy)nucleoside triphosphate pyrophosphohydrolase 2516205..2516612 Escherichia coli O157:H7 str. EDL933 961730 NP_288193.1 CDS Z2792 NC_002655.2 2516578 2516850 R hypothetical protein complement(2516578..2516850) Escherichia coli O157:H7 str. EDL933 961731 NP_288194.1 CDS gdhA NC_002655.2 2517086 2518429 D converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; glutamate dehydrogenase 2517086..2518429 Escherichia coli O157:H7 str. EDL933 961732 NP_288195.1 CDS Z2795 NC_002655.2 2518546 2519430 R hypothetical protein complement(2518546..2519430) Escherichia coli O157:H7 str. EDL933 961733 NP_288196.1 CDS topB NC_002655.2 2519714 2521675 R decatenates replicating daughter chromosomes; DNA topoisomerase III complement(2519714..2521675) Escherichia coli O157:H7 str. EDL933 961734 NP_288197.1 CDS selD NC_002655.2 2521680 2522723 R catalyzes the formation of selenophosphate from selenide and ATP; selenophosphate synthetase complement(2521680..2522723) Escherichia coli O157:H7 str. EDL933 961735 NP_288198.1 CDS ydjA NC_002655.2 2522840 2523391 R hypothetical protein complement(2522840..2523391) Escherichia coli O157:H7 str. EDL933 961736 NP_288199.1 CDS sppA NC_002655.2 2523552 2525408 D SppA; catalyzes the degradation of cleaved signal peptides; essential to maintain secretion of mature proteins across the membrane; protease 4 2523552..2525408 Escherichia coli O157:H7 str. EDL933 961737 NP_288200.1 CDS Z2800 NC_002655.2 2525431 2526234 D hypothetical protein 2525431..2526234 Escherichia coli O157:H7 str. EDL933 961738 NP_288201.1 CDS ansA NC_002655.2 2526366 2527382 D converts asparagine to aspartate and ammonia; asparaginase 2526366..2527382 Escherichia coli O157:H7 str. EDL933 961739 NP_288202.2 CDS ydjB NC_002655.2 2527393 2528034 D catalyzes the formation of nicotinate from nicotinamide in NAD biosynthesis and the formation of pyrazinoate from pyrazinamide; nicotinamidase/pyrazinamidase 2527393..2528034 Escherichia coli O157:H7 str. EDL933 961740 NP_288203.1 CDS ydjE NC_002655.2 2528127 2529377 R transporter complement(2528127..2529377) Escherichia coli O157:H7 str. EDL933 961741 NP_288204.1 CDS Z2804 NC_002655.2 2529440 2529766 D hypothetical protein 2529440..2529766 Escherichia coli O157:H7 str. EDL933 961742 NP_288205.1 CDS Z2806 NC_002655.2 2529766 2530653 D transposase 2529766..2530653 Escherichia coli O157:H7 str. EDL933 961743 NP_288206.1 CDS Z2808 NC_002655.2 2530916 2531674 R DEOR-type transcriptional regulator complement(2530916..2531674) Escherichia coli O157:H7 str. EDL933 961744 NP_288207.1 CDS Z2809 NC_002655.2 2531811 2532791 R hypothetical protein complement(2531811..2532791) Escherichia coli O157:H7 str. EDL933 961745 NP_288208.1 CDS Z2810 NC_002655.2 2532801 2533733 R kinase complement(2532801..2533733) Escherichia coli O157:H7 str. EDL933 961746 NP_288209.1 CDS Z2811 NC_002655.2 2533738 2534574 R aldolase complement(2533738..2534574) Escherichia coli O157:H7 str. EDL933 961747 NP_288210.1 CDS ydjJ NC_002655.2 2534595 2535638 R oxidoreductase complement(2534595..2535638) Escherichia coli O157:H7 str. EDL933 961748 NP_288211.1 CDS Z2813 NC_002655.2 2535655 2537034 R transporter complement(2535655..2537034) Escherichia coli O157:H7 str. EDL933 961749 NP_288212.1 CDS Z2815 NC_002655.2 2537061 2538137 R oxidoreductase complement(2537061..2538137) Escherichia coli O157:H7 str. EDL933 961750 NP_288213.1 CDS Z2816 NC_002655.2 2538507 2538824 R hypothetical protein complement(2538507..2538824) Escherichia coli O157:H7 str. EDL933 961751 NP_288214.1 CDS yeaA NC_002655.2 2538821 2539234 R this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress; methionine sulfoxide reductase B complement(2538821..2539234) Escherichia coli O157:H7 str. EDL933 961752 NP_288215.1 CDS gapA NC_002655.2 2539576 2540571 D catalyzes the formation of 3-phospho-D-glyceroyl phosphate from D-glyceraldehyde 3-phosphate; glyceraldehyde-3-phosphate dehydrogenase 2539576..2540571 Escherichia coli O157:H7 str. EDL933 961753 NP_288216.1 CDS yeaD NC_002655.2 2540634 2541539 D hypothetical protein 2540634..2541539 Escherichia coli O157:H7 str. EDL933 961754 NP_288217.1 CDS Z2821 NC_002655.2 2541590 2542444 R aldehyde reductase complement(2541590..2542444) Escherichia coli O157:H7 str. EDL933 961755 NP_288218.1 CDS yeaF NC_002655.2 2542534 2543280 R hypothetical protein complement(2542534..2543280) Escherichia coli O157:H7 str. EDL933 961756 NP_288219.1 CDS yeaG NC_002655.2 2543716 2545650 D hypothetical protein 2543716..2545650 Escherichia coli O157:H7 str. EDL933 961757 NP_288220.1 CDS yeaH NC_002655.2 2545763 2547046 D hypothetical protein 2545763..2547046 Escherichia coli O157:H7 str. EDL933 961758 NP_288221.1 CDS yeaI NC_002655.2 2547334 2548668 D hypothetical protein 2547334..2548668 Escherichia coli O157:H7 str. EDL933 961759 NP_288222.1 CDS yeaJ NC_002655.2 2548849 2550339 D hypothetical protein 2548849..2550339 Escherichia coli O157:H7 str. EDL933 961760 NP_288223.1 CDS yeaK NC_002655.2 2550382 2550885 D hypothetical protein 2550382..2550885 Escherichia coli O157:H7 str. EDL933 961761 NP_288224.1 CDS Z2828 NC_002655.2 2550886 2551038 R hypothetical protein complement(2550886..2551038) Escherichia coli O157:H7 str. EDL933 961762 NP_288225.1 CDS yeaL NC_002655.2 2551160 2551606 D hypothetical protein 2551160..2551606 Escherichia coli O157:H7 str. EDL933 961763 NP_288226.1 CDS yeaM NC_002655.2 2551563 2552384 R AraC family transcriptional regulator complement(2551563..2552384) Escherichia coli O157:H7 str. EDL933 961764 NP_288227.1 CDS yeaN NC_002655.2 2552481 2553662 D amino acid/amine transport protein 2552481..2553662 Escherichia coli O157:H7 str. EDL933 961765 NP_288228.2 CDS yeaO NC_002655.2 2553717 2554064 D hypothetical protein 2553717..2554064 Escherichia coli O157:H7 str. EDL933 961766 NP_288229.1 CDS yoaF NC_002655.2 2554086 2554340 R hypothetical protein complement(2554086..2554340) Escherichia coli O157:H7 str. EDL933 961767 NP_288230.1 CDS Z2836m NC_002655.2 2554523 2555548 D diguanylate cyclase 2554523..2555548 Escherichia coli O157:H7 str. EDL933 959645 NP_288231.1 CDS yeaQ NC_002655.2 2555815 2556063 R hypothetical protein complement(2555815..2556063) Escherichia coli O157:H7 str. EDL933 961768 NP_288232.1 CDS yoaG NC_002655.2 2556210 2556392 R hypothetical protein complement(2556210..2556392) Escherichia coli O157:H7 str. EDL933 961769 NP_288233.1 CDS yeaR NC_002655.2 2556396 2556755 R hypothetical protein complement(2556396..2556755) Escherichia coli O157:H7 str. EDL933 961770 NP_288234.1 CDS yeaS NC_002655.2 2556928 2557566 R leucine export protein LeuE complement(2556928..2557566) Escherichia coli O157:H7 str. EDL933 961771 NP_288235.1 CDS yeaT NC_002655.2 2557693 2558637 R LysR family transcriptional regulator complement(2557693..2558637) Escherichia coli O157:H7 str. EDL933 961772 NP_288236.1 CDS yeaU NC_002655.2 2558719 2559804 D tartrate dehydrogenase 2558719..2559804 Escherichia coli O157:H7 str. EDL933 961773 NP_288237.1 CDS yeaV NC_002655.2 2560220 2561665 D member of the betaine, carnitine, choline transporter (BCCT) family; unknown function; transporter 2560220..2561665 Escherichia coli O157:H7 str. EDL933 961774 NP_288238.1 CDS yeaW NC_002655.2 2561697 2562821 D hypothetical protein 2561697..2562821 Escherichia coli O157:H7 str. EDL933 961775 NP_288239.1 CDS yeaX NC_002655.2 2562877 2563842 D diogenase subunit beta 2562877..2563842 Escherichia coli O157:H7 str. EDL933 961776 NP_288240.1 CDS rnd NC_002655.2 2563897 2565024 R ribonuclease D complement(2563897..2565024) Escherichia coli O157:H7 str. EDL933 961777 NP_288241.1 CDS fadD NC_002655.2 2565094 2566779 R Activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase complement(2565094..2566779) Escherichia coli O157:H7 str. EDL933 961778 NP_288242.1 CDS Z2849 NC_002655.2 2566984 2567565 R hypothetical protein complement(2566984..2567565) Escherichia coli O157:H7 str. EDL933 961779 NP_288243.1 CDS yeaZ NC_002655.2 2567605 2568300 R hypothetical protein complement(2567605..2568300) Escherichia coli O157:H7 str. EDL933 961780 NP_288244.1 CDS Z2851 NC_002655.2 2568358 2570268 R hypothetical protein complement(2568358..2570268) Escherichia coli O157:H7 str. EDL933 961781 NP_288245.1 CDS Z2852 NC_002655.2 2570352 2570744 D hypothetical protein 2570352..2570744 Escherichia coli O157:H7 str. EDL933 961782 NP_288246.1 CDS Z2853 NC_002655.2 2571106 2571465 D hypothetical protein 2571106..2571465 Escherichia coli O157:H7 str. EDL933 961783 NP_288247.1 CDS Z2854 NC_002655.2 2571585 2571764 R hypothetical protein complement(2571585..2571764) Escherichia coli O157:H7 str. EDL933 961784 NP_288248.1 CDS pabB NC_002655.2 2571838 2573199 D catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine; para-aminobenzoate synthase component I 2571838..2573199 Escherichia coli O157:H7 str. EDL933 961785 NP_288249.1 CDS yeaB NC_002655.2 2573203 2573781 D hypothetical protein 2573203..2573781 Escherichia coli O157:H7 str. EDL933 961786 NP_288250.1 CDS sdaA NC_002655.2 2573965 2575329 D L-serine dehydratase 1 2573965..2575329 Escherichia coli O157:H7 str. EDL933 961787 NP_288251.1 CDS Z2858 NC_002655.2 2575430 2577058 D hypothetical protein 2575430..2577058 Escherichia coli O157:H7 str. EDL933 961788 NP_288252.1 CDS yoaE NC_002655.2 2577062 2578618 R transporter complement(2577062..2578618) Escherichia coli O157:H7 str. EDL933 961789 NP_288253.1 CDS manX NC_002655.2 2579083 2580054 D PTS system mannose-specific transporter subunit IIAB 2579083..2580054 Escherichia coli O157:H7 str. EDL933 961790 NP_288254.1 CDS manY NC_002655.2 2580117 2580917 D PTS enzyme IIC, mannose-specific 2580117..2580917 Escherichia coli O157:H7 str. EDL933 961791 NP_288255.1 CDS manZ NC_002655.2 2580921 2581781 D hosphoenolpyruvate-dependent sugar phosphotransferase system catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IID with IIC forms the translocation channel; PTS system mannose-specific transporter subunit IID 2580921..2581781 Escherichia coli O157:H7 str. EDL933 961792 NP_288256.1 CDS Z2863 NC_002655.2 2581836 2582294 D hypothetical protein 2581836..2582294 Escherichia coli O157:H7 str. EDL933 961793 NP_288257.1 CDS Z2864 NC_002655.2 2582670 2583290 D membrane protein YebN; hypothetical protein 2582670..2583290 Escherichia coli O157:H7 str. EDL933 961794 NP_288258.1 CDS rrmA NC_002655.2 2583287 2584096 R methylates the guanosine in position 745 of 23S rRNA; required for translation and cell growth; 23S rRNA methyltransferase complement(2583287..2584096) Escherichia coli O157:H7 str. EDL933 961795 NP_288259.1 CDS cspC NC_002655.2 2584262 2584471 R cold shock-like protein CspC complement(2584262..2584471) Escherichia coli O157:H7 str. EDL933 961796 NP_288260.1 CDS Z2869 NC_002655.2 2584484 2584627 R hypothetical protein complement(2584484..2584627) Escherichia coli O157:H7 str. EDL933 961797 NP_288261.1 CDS Z2871 NC_002655.2 2585296 2585583 R hypothetical protein complement(2585296..2585583) Escherichia coli O157:H7 str. EDL933 961798 NP_288262.1 CDS Z2872 NC_002655.2 2585658 2585801 R hypothetical protein complement(2585658..2585801) Escherichia coli O157:H7 str. EDL933 961799 NP_288263.1 CDS Z2873 NC_002655.2 2585961 2586200 D No significant matches; hypothetical protein 2585961..2586200 Escherichia coli O157:H7 str. EDL933 961800 NP_288264.1 CDS Z2874 NC_002655.2 2586345 2587136 R regulator complement(2586345..2587136) Escherichia coli O157:H7 str. EDL933 961801 NP_288265.1 CDS Z2875 NC_002655.2 2587202 2588686 D transporter 2587202..2588686 Escherichia coli O157:H7 str. EDL933 961802 NP_288266.1 CDS htpX NC_002655.2 2588732 2589613 R metalloprotease; heat shock protein HtpX complement(2588732..2589613) Escherichia coli O157:H7 str. EDL933 961803 NP_288267.1 CDS prc NC_002655.2 2589805 2591853 R Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3; carboxy-terminal protease complement(2589805..2591853) Escherichia coli O157:H7 str. EDL933 961804 NP_288268.1 CDS proQ NC_002655.2 2591873 2592571 R affects solute and DNA transport through an unknown mechanism; solute/DNA competence effector complement(2591873..2592571) Escherichia coli O157:H7 str. EDL933 959633 NP_288269.1 CDS Z2879 NC_002655.2 2592668 2593219 R hypothetical protein complement(2592668..2593219) Escherichia coli O157:H7 str. EDL933 961805 NP_288270.1 CDS Z2880 NC_002655.2 2593295 2594578 D hypothetical protein 2593295..2594578 Escherichia coli O157:H7 str. EDL933 961806 NP_288271.1 CDS Z2881 NC_002655.2 2594541 2597180 D hypothetical protein 2594541..2597180 Escherichia coli O157:H7 str. EDL933 961807 NP_288272.1 CDS yebU NC_002655.2 2597255 2598700 D in Escherichia coli this enzyme specifically methylates C1407 of the 16S rRNA; rRNA (cytosine-C(5)-)-methyltransferase RsmF 2597255..2598700 Escherichia coli O157:H7 str. EDL933 961808 NP_288273.1 CDS Z2883 NC_002655.2 2598803 2599054 D hypothetical protein 2598803..2599054 Escherichia coli O157:H7 str. EDL933 961809 NP_288274.1 CDS Z2884 NC_002655.2 2599075 2599350 D hypothetical protein 2599075..2599350 Escherichia coli O157:H7 str. EDL933 961810 NP_288275.1 CDS pphA NC_002655.2 2599351 2600010 R Plays a key role in signaling protein misfolding via the cpxR/cpxA transducing system; modulates the phosphorylated status of many phosphoproteins; serine/threonine protein phosphatase 1 complement(2599351..2600010) Escherichia coli O157:H7 str. EDL933 961811 NP_288276.1 CDS Z2887 NC_002655.2 2600403 2600744 R hypothetical protein complement(2600403..2600744) Escherichia coli O157:H7 str. EDL933 961812 NP_288277.1 CDS Z2888 NC_002655.2 2600757 2601629 R resistance protein complement(2600757..2601629) Escherichia coli O157:H7 str. EDL933 961813 NP_288278.1 CDS Z2889 NC_002655.2 2601633 2602007 R hypothetical protein complement(2601633..2602007) Escherichia coli O157:H7 str. EDL933 961814 NP_288279.1 CDS holE NC_002655.2 2602146 2602376 D DNA polymerase III subunit theta 2602146..2602376 Escherichia coli O157:H7 str. EDL933 961815 NP_288280.1 CDS Z2893 NC_002655.2 2602478 2603134 D hypothetical protein 2602478..2603134 Escherichia coli O157:H7 str. EDL933 961816 NP_288281.1 CDS Z2894 NC_002655.2 2603158 2603820 D 3'-5' exonuclease activity on single or double-strand DNA; exodeoxyribonuclease X 2603158..2603820 Escherichia coli O157:H7 str. EDL933 961817 NP_288282.1 CDS ptrB NC_002655.2 2603817 2605877 R PtrB; oligopeptidase that cleaves peptide bonds following arginine and lysine residues; protease 2 complement(2603817..2605877) Escherichia coli O157:H7 str. EDL933 961818 NP_288283.1 CDS yebE NC_002655.2 2606086 2606745 R hypothetical protein complement(2606086..2606745) Escherichia coli O157:H7 str. EDL933 961819 NP_288284.1 CDS yebF NC_002655.2 2607073 2607441 R secreted protein; unknown function; hypothetical protein complement(2607073..2607441) Escherichia coli O157:H7 str. EDL933 961820 NP_288285.1 CDS yebG NC_002655.2 2607496 2607786 R DNA damage-inducible protein YebG complement(2607496..2607786) Escherichia coli O157:H7 str. EDL933 961821 NP_288286.1 CDS purT NC_002655.2 2607920 2609098 D non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis; phosphoribosylglycinamide formyltransferase 2 2607920..2609098 Escherichia coli O157:H7 str. EDL933 961822 NP_288287.1 CDS eda NC_002655.2 2609154 2609795 R catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate; keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase complement(2609154..2609795) Escherichia coli O157:H7 str. EDL933 961823 NP_288288.1 CDS edd NC_002655.2 2609832 2611643 R catalyzes the formation of 2-dehydro-3-deoxy-6-phospho-D-gluconate from 6-phospho-D-gluconate; phosphogluconate dehydratase complement(2609832..2611643) Escherichia coli O157:H7 str. EDL933 961824 NP_288289.1 CDS zwf NC_002655.2 2611878 2613353 R catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase complement(2611878..2613353) Escherichia coli O157:H7 str. EDL933 961825 NP_288290.1 CDS yebK NC_002655.2 2613691 2614560 D Represses the expression of the zwf, eda, glp and gap; DNA-binding transcriptional regulator HexR 2613691..2614560 Escherichia coli O157:H7 str. EDL933 961826 NP_288291.1 CDS pykA NC_002655.2 2614688 2616130 D catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 2614688..2616130 Escherichia coli O157:H7 str. EDL933 961827 NP_288292.1 CDS msbB NC_002655.2 2616261 2617232 R Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase complement(2616261..2617232) Escherichia coli O157:H7 str. EDL933 961828 NP_288293.2 CDS yebA NC_002655.2 2617352 2618674 R hypothetical protein complement(2617352..2618674) Escherichia coli O157:H7 str. EDL933 961829 NP_288294.2 CDS znuA NC_002655.2 2618690 2619622 R involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter periplasmic protein complement(2618690..2619622) Escherichia coli O157:H7 str. EDL933 961830 NP_288295.1 CDS znuC NC_002655.2 2619701 2620456 D involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter ATPase 2619701..2620456 Escherichia coli O157:H7 str. EDL933 961831 NP_288296.1 CDS znuB NC_002655.2 2620453 2621238 D involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter membrane protein 2620453..2621238 Escherichia coli O157:H7 str. EDL933 961832 NP_288297.1 CDS ruvB NC_002655.2 2621484 2622494 R promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB complement(2621484..2622494) Escherichia coli O157:H7 str. EDL933 961833 NP_288298.1 CDS ruvA NC_002655.2 2622503 2623114 R plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA complement(2622503..2623114) Escherichia coli O157:H7 str. EDL933 961834 NP_288299.2 CDS yebB NC_002655.2 2623389 2623991 D hypothetical protein 2623389..2623991 Escherichia coli O157:H7 str. EDL933 961835 NP_288300.1 CDS ruvC NC_002655.2 2623993 2624514 R endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity; Holliday junction resolvase complement(2623993..2624514) Escherichia coli O157:H7 str. EDL933 961836 NP_288301.1 CDS yebC NC_002655.2 2624549 2625289 R hypothetical protein complement(2624549..2625289) Escherichia coli O157:H7 str. EDL933 961837 NP_288302.1 CDS ntpA NC_002655.2 2625318 2625770 R converts dATP to dAMP and pyrophosphate; dATP pyrophosphohydrolase complement(2625318..2625770) Escherichia coli O157:H7 str. EDL933 961838 NP_288303.1 CDS aspS NC_002655.2 2625888 2627660 R catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase complement(2625888..2627660) Escherichia coli O157:H7 str. EDL933 961839 NP_288304.2 CDS yecD NC_002655.2 2627970 2628536 D hypothetical protein 2627970..2628536 Escherichia coli O157:H7 str. EDL933 961840 NP_288305.1 CDS yecE NC_002655.2 2628533 2629351 D hypothetical protein 2628533..2629351 Escherichia coli O157:H7 str. EDL933 961841 NP_288306.2 CDS yecN NC_002655.2 2629404 2629799 D hypothetical protein 2629404..2629799 Escherichia coli O157:H7 str. EDL933 961842 NP_288307.1 CDS yecO NC_002655.2 2629840 2630583 D hypothetical protein 2629840..2630583 Escherichia coli O157:H7 str. EDL933 961843 NP_288308.1 CDS yecP NC_002655.2 2630580 2631551 D hypothetical protein 2630580..2631551 Escherichia coli O157:H7 str. EDL933 961844 NP_288309.1 CDS bisZ NC_002655.2 2631716 2634163 R biotin sulfoxide reductase complement(2631716..2634163) Escherichia coli O157:H7 str. EDL933 961845 NP_288310.1 CDS yecK NC_002655.2 2634170 2635270 R cytochrome C complement(2634170..2635270) Escherichia coli O157:H7 str. EDL933 961846 NP_288311.1 CDS cutC NC_002655.2 2635661 2636407 R copper homeostasis protein CutC complement(2635661..2636407) Escherichia coli O157:H7 str. EDL933 959636 NP_288312.1 CDS yecM NC_002655.2 2636421 2636993 R hypothetical protein complement(2636421..2636993) Escherichia coli O157:H7 str. EDL933 961847 NP_288313.1 CDS argS NC_002655.2 2637203 2638936 D catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 2637203..2638936 Escherichia coli O157:H7 str. EDL933 961848 NP_288314.1 CDS yecT NC_002655.2 2639113 2639601 D hypothetical protein 2639113..2639601 Escherichia coli O157:H7 str. EDL933 961849 NP_288315.1 CDS flhE NC_002655.2 2639721 2640113 R flagellar protein complement(2639721..2640113) Escherichia coli O157:H7 str. EDL933 961850 NP_288316.1 CDS flhA NC_002655.2 2640113 2642191 R membrane protein involved in the flagellar export apparatus; flagellar biosynthesis protein FlhA complement(2640113..2642191) Escherichia coli O157:H7 str. EDL933 961851 NP_288317.1 CDS flhB NC_002655.2 2642184 2643332 R membrane protein responsible for substrate specificity switching from rod/hook-type export to filament-type export; flagellar biosynthesis protein FlhB complement(2642184..2643332) Escherichia coli O157:H7 str. EDL933 961852 NP_288318.1 CDS cheZ NC_002655.2 2643534 2644178 R cytosolic phosphatase which functions in the chemotaxis signal transduction complex by controlling the level of phosphorylated CheY through dephosphorylation; chemotaxis regulator CheZ complement(2643534..2644178) Escherichia coli O157:H7 str. EDL933 961853 NP_288319.1 CDS cheY NC_002655.2 2644189 2644578 R chemotaxis regulator that, when phosphorylated, interacts with the flagellar motor causing the flagella to spin clockwise which causes the cell to tumble; chemotaxis regulatory protein CheY complement(2644189..2644578) Escherichia coli O157:H7 str. EDL933 961854 NP_288320.1 CDS cheB NC_002655.2 2644593 2645642 R regulates chemotaxis by demethylation of methyl-accepting chemotaxis proteins; chemotaxis-specific methylesterase complement(2644593..2645642) Escherichia coli O157:H7 str. EDL933 961855 NP_288321.1 CDS cheR NC_002655.2 2645645 2646505 R methylates the MCP; chemotaxis methyltransferase CheR complement(2645645..2646505) Escherichia coli O157:H7 str. EDL933 961856 NP_288322.1 CDS tap NC_002655.2 2646524 2648125 R mediates taxis toward dipeptides; methyl-accepting protein IV complement(2646524..2648125) Escherichia coli O157:H7 str. EDL933 961857 NP_288323.1 CDS tar NC_002655.2 2648171 2649832 R methyl-accepting chemotaxis protein II complement(2648171..2649832) Escherichia coli O157:H7 str. EDL933 961858 NP_288324.1 CDS cheW NC_002655.2 2649975 2650478 R purine-binding chemotaxis protein complement(2649975..2650478) Escherichia coli O157:H7 str. EDL933 961859 NP_288325.1 CDS cheA NC_002655.2 2650499 2652463 R chemotactic sensory histidine kinase in two-component regulatory system with CheB and CheY; sensory histidine kinase/signal sensing protein; CheA is the histidine kinase component; chemotaxis protein CheA complement(2650499..2652463) Escherichia coli O157:H7 str. EDL933 961860 NP_288326.1 CDS motB NC_002655.2 2652468 2653394 R with MotA forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine; flagellar motor protein MotB complement(2652468..2653394) Escherichia coli O157:H7 str. EDL933 961861 NP_288327.1 CDS motA NC_002655.2 2653391 2654278 R With MotB forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine; flagellar motor protein MotA complement(2653391..2654278) Escherichia coli O157:H7 str. EDL933 961862 NP_288328.1 CDS flhC NC_002655.2 2654405 2654983 R With FlhD is involved in the activation of class 2 flagellar genes and as well as a number of other genetic systems; transcriptional activator FlhC complement(2654405..2654983) Escherichia coli O157:H7 str. EDL933 961863 NP_288329.1 CDS flhD NC_002655.2 2654986 2655345 R with FlhC is involved in the activation of class 2 flagellar genes and is involved in the regulation of a number of other genetic systems; transcriptional activator FlhD complement(2654986..2655345) Escherichia coli O157:H7 str. EDL933 961864 NP_288331.1 CDS yecG NC_002655.2 2656116 2656544 D ppGpp-dependent; membrane-associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress; universal stress protein UspC 2656116..2656544 Escherichia coli O157:H7 str. EDL933 961866 NP_288332.1 CDS otsA NC_002655.2 2656551 2657975 R trehalose-6-phosphate synthase complement(2656551..2657975) Escherichia coli O157:H7 str. EDL933 961867 NP_288333.1 CDS otsB NC_002655.2 2657950 2658750 R biosynthetic; catalyzes the formation of trehalose and phosphate from trehalose-6-phosphate; expression is increased under osmotic stress and induced during the transition to stationary phase and by decreased temperature; trehalose-6-phosphate phosphatase complement(2657950..2658750) Escherichia coli O157:H7 str. EDL933 961868 NP_288334.1 CDS araH NC_002655.2 2658917 2659906 R Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose; L-arabinose transporter permease complement(2658917..2659906) Escherichia coli O157:H7 str. EDL933 959637 NP_288335.1 CDS araG NC_002655.2 2659918 2661432 R Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose; L-arabinose transporter ATP-binding protein complement(2659918..2661432) Escherichia coli O157:H7 str. EDL933 961869 NP_288336.1 CDS araF NC_002655.2 2661502 2662491 R L-arabinose-binding periplasmic protein complement(2661502..2662491) Escherichia coli O157:H7 str. EDL933 961870 NP_288337.1 CDS yecI NC_002655.2 2663288 2663791 D ferritin 2663288..2663791 Escherichia coli O157:H7 str. EDL933 961871 NP_288339.1 CDS Z2959 NC_002655.2 2664585 2664908 D hypothetical protein 2664585..2664908 Escherichia coli O157:H7 str. EDL933 961873 NP_288340.1 CDS ftn NC_002655.2 2665079 2665576 D cytoplasmic iron storage protein; ferritin 2665079..2665576 Escherichia coli O157:H7 str. EDL933 961874 NP_288341.1 CDS yecH NC_002655.2 2665613 2665852 R hypothetical protein complement(2665613..2665852) Escherichia coli O157:H7 str. EDL933 961875 NP_288342.1 CDS tyrP NC_002655.2 2666044 2667255 D tyrosine-specific transporter 2666044..2667255 Escherichia coli O157:H7 str. EDL933 961876 NP_288343.1 CDS yecA NC_002655.2 2667317 2667982 R hypothetical protein complement(2667317..2667982) Escherichia coli O157:H7 str. EDL933 961877 NP_288344.1 CDS intT NC_002655.2 2668339 2669340 R integrase for prophage CP-933T complement(2668339..2669340) Escherichia coli O157:H7 str. EDL933 961878 NP_288345.1 CDS Z2967 NC_002655.2 2669346 2669693 R No significant matches; hypothetical protein complement(2669346..2669693) Escherichia coli O157:H7 str. EDL933 961879 NP_288346.1 CDS Z2968 NC_002655.2 2669723 2670373 R No significant matches; hypothetical protein complement(2669723..2670373) Escherichia coli O157:H7 str. EDL933 961880 NP_288347.1 CDS Z2969 NC_002655.2 2670389 2670793 R hypothetical protein complement(2670389..2670793) Escherichia coli O157:H7 str. EDL933 961881 NP_288348.1 CDS coxT NC_002655.2 2671092 2671295 D regulator for prophage CP-933T 2671092..2671295 Escherichia coli O157:H7 str. EDL933 961882 NP_288349.1 CDS Z2971 NC_002655.2 2671317 2671667 D No significant matches; hypothetical protein 2671317..2671667 Escherichia coli O157:H7 str. EDL933 961883 NP_288350.1 CDS Z2972 NC_002655.2 2671678 2671956 D No significant matches; hypothetical protein 2671678..2671956 Escherichia coli O157:H7 str. EDL933 961884 NP_288351.1 CDS Z2973 NC_002655.2 2671968 2672210 D No significant matches; hypothetical protein 2671968..2672210 Escherichia coli O157:H7 str. EDL933 961885 NP_288352.1 CDS Z2974 NC_002655.2 2672413 2672829 D No significant matches; hypothetical protein 2672413..2672829 Escherichia coli O157:H7 str. EDL933 961886 NP_288353.1 CDS Z2975 NC_002655.2 2673316 2673615 D No significant matches; hypothetical protein 2673316..2673615 Escherichia coli O157:H7 str. EDL933 961887 NP_288354.1 CDS Z2976 NC_002655.2 2673938 2674168 D No significant matches; hypothetical protein 2673938..2674168 Escherichia coli O157:H7 str. EDL933 961888 NP_288355.1 CDS Z2977 NC_002655.2 2674241 2674606 D No significant matches; hypothetical protein 2674241..2674606 Escherichia coli O157:H7 str. EDL933 961889 NP_288356.1 CDS Z2978 NC_002655.2 2674613 2677435 D replication protein for prophage CP-933T 2674613..2677435 Escherichia coli O157:H7 str. EDL933 961890 NP_288357.1 CDS Z2979 NC_002655.2 2677512 2678471 D stability/partitioning protein encoded within prophage CP-933T 2677512..2678471 Escherichia coli O157:H7 str. EDL933 961891 NP_288358.1 CDS Z2980 NC_002655.2 2678476 2678790 D stability/partitioning protein encoded within CP-933T 2678476..2678790 Escherichia coli O157:H7 str. EDL933 961892 NP_288359.1 CDS Z2981 NC_002655.2 2678810 2679499 R IS629 transposase encoded within prophage CP-933T complement(2678810..2679499) Escherichia coli O157:H7 str. EDL933 961893 NP_288360.1 CDS Z2982 NC_002655.2 2679499 2679825 R prophage-associated protein complement(2679499..2679825) Escherichia coli O157:H7 str. EDL933 961894 NP_288361.1 CDS Z2983 NC_002655.2 2679996 2680412 D tail fiber assembly protein of prophage CP-933T 2679996..2680412 Escherichia coli O157:H7 str. EDL933 961895 NP_288362.1 CDS Z2984 NC_002655.2 2680456 2681061 R serine acetlyltransferase of prophage CP-933T complement(2680456..2681061) Escherichia coli O157:H7 str. EDL933 961896 NP_288363.1 CDS Z2985 NC_002655.2 2681185 2681679 R tail fiber protein of prophage CP-933T complement(2681185..2681679) Escherichia coli O157:H7 str. EDL933 961897 NP_288364.1 CDS Z2986 NC_002655.2 2681686 2682522 R tail fiber protein of prophage CP-933T complement(2681686..2682522) Escherichia coli O157:H7 str. EDL933 961898 NP_288365.1 CDS Z2987 NC_002655.2 2682399 2684489 R tail fiber component of prophage CP-933T complement(2682399..2684489) Escherichia coli O157:H7 str. EDL933 961899 NP_288366.1 CDS Z2988 NC_002655.2 2684476 2684631 R tail fiber protein component of prophage CP-933T complement(2684476..2684631) Escherichia coli O157:H7 str. EDL933 961900 NP_288367.1 CDS Z2989 NC_002655.2 2684640 2685005 R hypothetical protein complement(2684640..2685005) Escherichia coli O157:H7 str. EDL933 961901 NP_288368.1 CDS Z2990 NC_002655.2 2685060 2685572 R tail fiber component of prophage CP-933T complement(2685060..2685572) Escherichia coli O157:H7 str. EDL933 961902 NP_288369.1 CDS Z2991 NC_002655.2 2685572 2686756 R tail sheath protein of prophage CP-933T complement(2685572..2686756) Escherichia coli O157:H7 str. EDL933 961903 NP_288370.1 CDS Z2992 NC_002655.2 2686884 2687237 D tail assembly protein of prophage CP-933T 2686884..2687237 Escherichia coli O157:H7 str. EDL933 961904 NP_288371.1 CDS tra8_2 NC_002655.2 2687188 2688378 R IS30 transposase encoded within prophage CP-933T complement(2687188..2688378) Escherichia coli O157:H7 str. EDL933 961905 NP_288372.1 CDS Z2994 NC_002655.2 2688478 2688870 R No significant matches; hypothetical protein complement(2688478..2688870) Escherichia coli O157:H7 str. EDL933 961906 NP_288373.1 CDS pgsA NC_002655.2 2689751 2690299 R phosphatidylglycerophosphate synthetase complement(2689751..2690299) Escherichia coli O157:H7 str. EDL933 961910 NP_288374.2 CDS uvrC NC_002655.2 2690356 2692188 R The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C complement(2690356..2692188) Escherichia coli O157:H7 str. EDL933 961911 NP_288375.1 CDS uvrY NC_002655.2 2692185 2692841 R in Escherichia coli the protein UvrY is part of a two-component system along with BarA that is needed for efficient switching between glycolytic and gluconeogenic carbon sources possibly by regulating the Csr system; in Salmonella SirA and BarA regulate virulence gene expression also via the Csr system; response regulator complement(2692185..2692841) Escherichia coli O157:H7 str. EDL933 961912 NP_288376.1 CDS yecF NC_002655.2 2693300 2693524 D hypothetical protein 2693300..2693524 Escherichia coli O157:H7 str. EDL933 961913 NP_288377.1 CDS sdiA NC_002655.2 2693592 2694314 R regulates genes involved in cell division; DNA-binding transcriptional activator SdiA complement(2693592..2694314) Escherichia coli O157:H7 str. EDL933 961914 NP_288378.1 CDS yecC NC_002655.2 2694544 2695296 R amino-acid ABC transporter ATP-binding protein YecC complement(2694544..2695296) Escherichia coli O157:H7 str. EDL933 961915 NP_288379.1 CDS yecS NC_002655.2 2695293 2695961 R transport system permease complement(2695293..2695961) Escherichia coli O157:H7 str. EDL933 961916 NP_288380.2 CDS yedO NC_002655.2 2695976 2696962 R catalyzes the formation of pyruvate from D-cysteine; D-cysteine desulfhydrase complement(2695976..2696962) Escherichia coli O157:H7 str. EDL933 961917 NP_288381.1 CDS fliY NC_002655.2 2697067 2697867 R cystine transporter subunit complement(2697067..2697867) Escherichia coli O157:H7 str. EDL933 961918 NP_288382.1 CDS fliZ NC_002655.2 2697955 2698542 R expression activator of the class 2 type of flagellar operons, essential to achieve maximal cell motility; activator of type 1 fimbrial gene expression; cell density-responsive regulator; FliZ in Salmonella typhimurium induces HilA, an activator of invasion genes necessary to achieve full virulence; flagella biosynthesis protein FliZ complement(2697955..2698542) Escherichia coli O157:H7 str. EDL933 961919 NP_288383.1 CDS fliA NC_002655.2 2698552 2699271 R sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor directs late flagellar biosynthesis genes; flagellar biosynthesis sigma factor complement(2698552..2699271) Escherichia coli O157:H7 str. EDL933 961920 NP_288384.1 CDS fliC NC_002655.2 2699591 2701348 R structural flagella protein; individual Salmonella serotypes usually alternate between the production of 2 antigenic forms of flagella, termed phase 1 and phase 2, each specified by separate structural genes; flagellin complement(2699591..2701348) Escherichia coli O157:H7 str. EDL933 961921 NP_288385.1 CDS fliD NC_002655.2 2701614 2703011 D involved in flagellin assembly; flagellar capping protein 2701614..2703011 Escherichia coli O157:H7 str. EDL933 961922 NP_288386.1 CDS fliS NC_002655.2 2703036 2703446 D flagellin specific chaperone; flagellar protein FliS 2703036..2703446 Escherichia coli O157:H7 str. EDL933 961923 NP_288387.1 CDS fliT NC_002655.2 2703446 2703811 D binds flagellar cap subunits (FliD) and seems to prevents their oligomerization prior to its translocation through the flagellum-specific type III export pathway; acts as a repressor of flagellar class 2 operons by preventing FlhD2C2 to bind the promoter and inhibiting the FlhD2C2-dependent transcription; member of the type III cytoplasmic chaperone family; flagellar biosynthesis protein FliT 2703446..2703811 Escherichia coli O157:H7 str. EDL933 961925 NP_288388.1 CDS amyA NC_002655.2 2703889 2705376 D converts 1,4-alpha-D-glucans to maltodextrin; alpha-amylase 2703889..2705376 Escherichia coli O157:H7 str. EDL933 961926 NP_288389.1 CDS yedD NC_002655.2 2705410 2705823 R hypothetical protein complement(2705410..2705823) Escherichia coli O157:H7 str. EDL933 961927 NP_288390.1 CDS yedE NC_002655.2 2706010 2707215 D hypothetical protein 2706010..2707215 Escherichia coli O157:H7 str. EDL933 961928 NP_288391.1 CDS yedF NC_002655.2 2707212 2707445 D hypothetical protein 2707212..2707445 Escherichia coli O157:H7 str. EDL933 961929 NP_288392.1 CDS yedK NC_002655.2 2707554 2708222 D hypothetical protein 2707554..2708222 Escherichia coli O157:H7 str. EDL933 961930 NP_288393.1 CDS yedL NC_002655.2 2708333 2708812 D hypothetical protein 2708333..2708812 Escherichia coli O157:H7 str. EDL933 961931 NP_288394.1 CDS Z3023 NC_002655.2 2708950 2710089 R hypothetical protein complement(2708950..2710089) Escherichia coli O157:H7 str. EDL933 961932 NP_288395.1 CDS Z3025 NC_002655.2 2710471 2710770 D hypothetical protein 2710471..2710770 Escherichia coli O157:H7 str. EDL933 961933 NP_288396.1 CDS Z3026 NC_002655.2 2710908 2712047 R hypothetical protein complement(2710908..2712047) Escherichia coli O157:H7 str. EDL933 961934 NP_288397.1 CDS Z3024 NC_002655.2 2712198 2712476 D hypothetical protein 2712198..2712476 Escherichia coli O157:H7 str. EDL933 961935 NP_288398.1 CDS fliE NC_002655.2 2712396 2712710 R forms a junction between the M-ring and FlgB during flagella biosynthesis; flagellar hook-basal body protein FliE complement(2712396..2712710) Escherichia coli O157:H7 str. EDL933 961937 NP_288399.1 CDS fliF NC_002655.2 2712925 2714583 D the MS-ring anchors the flagellum to the cytoplasmic membrane; part of the flagellar basal body which consists of four rings L, P, S, and M mounted on a central rod; flagellar MS-ring protein 2712925..2714583 Escherichia coli O157:H7 str. EDL933 961938 NP_288400.1 CDS fliG NC_002655.2 2714576 2715571 D One of three proteins involved in switching the direction of the flagellar rotation; flagellar motor switch protein G 2714576..2715571 Escherichia coli O157:H7 str. EDL933 961939 NP_288401.2 CDS fliH NC_002655.2 2715564 2716250 D binds to and inhibits the function of flagella specific ATPase FliI; flagellar assembly protein H 2715564..2716250 Escherichia coli O157:H7 str. EDL933 961940 NP_288402.2 CDS fliI NC_002655.2 2716312 2717685 D involved in type III protein export during flagellum assembly; flagellum-specific ATP synthase 2716312..2717685 Escherichia coli O157:H7 str. EDL933 961941 NP_288403.1 CDS fliJ NC_002655.2 2717704 2718147 D rod/hook and filament chaperone; flagellar biosynthesis chaperone 2717704..2718147 Escherichia coli O157:H7 str. EDL933 961942 NP_288404.1 CDS fliK NC_002655.2 2718144 2719271 D flagellar hook-length control protein 2718144..2719271 Escherichia coli O157:H7 str. EDL933 961943 NP_288405.1 CDS fliL NC_002655.2 2719377 2719841 D interacts with cytoplasmic MS ring of the basal body and may act to stabilize the MotAB complexes which surround the MS ring; flagellar basal body protein FliL 2719377..2719841 Escherichia coli O157:H7 str. EDL933 961944 NP_288406.1 CDS fliM NC_002655.2 2719846 2720850 D with FliG and FliN makes up the switch complex which is involved in switching the direction of the flagella rotation; flagellar motor switch protein FliM 2719846..2720850 Escherichia coli O157:H7 str. EDL933 961945 NP_288407.1 CDS fliN NC_002655.2 2720847 2721260 D One of three proteins involved in switching the direction of the flagellar rotation; flagellar motor switch protein FliN 2720847..2721260 Escherichia coli O157:H7 str. EDL933 961946 NP_288408.2 CDS fliO NC_002655.2 2721263 2721628 D with FlhA, FlhB, FliP, FliQ and FliR is one of the membrane components of the flagellar export apparatus; flagellar biosynthesis protein FliO 2721263..2721628 Escherichia coli O157:H7 str. EDL933 961947 NP_288409.1 CDS fliP NC_002655.2 2721628 2722365 D FliP, with proteins FliQ and FliR, forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliP 2721628..2722365 Escherichia coli O157:H7 str. EDL933 961948 NP_288410.1 CDS fliQ NC_002655.2 2722375 2722644 D with proteins FliP and FliR forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliQ 2722375..2722644 Escherichia coli O157:H7 str. EDL933 961949 NP_288411.1 CDS fliR NC_002655.2 2722652 2723437 D FliR, with proteins FliP and FliQ, forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliR 2722652..2723437 Escherichia coli O157:H7 str. EDL933 961950 NP_288412.1 CDS rcsA NC_002655.2 2723727 2724350 D positive regulator for ctr capsule biosynthesis, positive transcription factor 2723727..2724350 Escherichia coli O157:H7 str. EDL933 961951 NP_288413.1 CDS dsrB NC_002655.2 2724394 2724582 R hypothetical protein complement(2724394..2724582) Escherichia coli O157:H7 str. EDL933 961952 NP_288414.1 CDS Z3043 NC_002655.2 2724730 2724972 D hypothetical protein 2724730..2724972 Escherichia coli O157:H7 str. EDL933 961953 NP_288415.1 CDS Z3045 NC_002655.2 2725270 2726085 D catalyzes the hydrolysis of mannosyl-3-phosphoglycerate to form the osmolyte mannosylglycerate; mannosyl-3-phosphoglycerate phosphatase 2725270..2726085 Escherichia coli O157:H7 str. EDL933 961955 NP_288416.1 CDS Z3047 NC_002655.2 2726082 2727776 R hypothetical protein complement(2726082..2727776) Escherichia coli O157:H7 str. EDL933 961956 NP_288417.1 CDS Z3048 NC_002655.2 2727948 2728130 R hypothetical protein complement(2727948..2728130) Escherichia coli O157:H7 str. EDL933 961957 NP_288418.1 CDS yedI NC_002655.2 2728209 2729126 R hypothetical protein complement(2728209..2729126) Escherichia coli O157:H7 str. EDL933 961958 NP_288419.1 CDS yedA NC_002655.2 2729299 2730219 D hypothetical protein 2729299..2730219 Escherichia coli O157:H7 str. EDL933 961959 NP_288420.1 CDS vsr NC_002655.2 2730208 2730678 R DNA mismatch endonuclease, patch repair protein complement(2730208..2730678) Escherichia coli O157:H7 str. EDL933 961960 NP_288421.1 CDS dcm NC_002655.2 2730659 2732077 R DNA cytosine methylase complement(2730659..2732077) Escherichia coli O157:H7 str. EDL933 961961 NP_288422.1 CDS yedJ NC_002655.2 2732144 2732839 R hypothetical protein complement(2732144..2732839) Escherichia coli O157:H7 str. EDL933 961962 NP_288423.1 CDS Z3056 NC_002655.2 2732935 2733243 R hypothetical protein complement(2732935..2733243) Escherichia coli O157:H7 str. EDL933 961966 NP_288424.1 CDS Z3057 NC_002655.2 2733780 2734454 D hypothetical protein 2733780..2734454 Escherichia coli O157:H7 str. EDL933 961967 NP_288425.1 CDS Z3058 NC_002655.2 2734421 2734996 D hypothetical protein 2734421..2734996 Escherichia coli O157:H7 str. EDL933 961968 NP_288426.1 CDS yedU NC_002655.2 2735588 2736439 D Hsp31 stabilizes early unfolding protein intermediates under severe heat stress; chaperone protein HchA 2735588..2736439 Escherichia coli O157:H7 str. EDL933 961970 NP_288427.1 CDS yedV NC_002655.2 2736547 2737905 R 2-component sensor protein complement(2736547..2737905) Escherichia coli O157:H7 str. EDL933 961972 NP_288428.2 CDS yedW NC_002655.2 2737905 2738576 R induced by CusR in the presence of copper; YedW induces the expression of the upstream gene yedV (encoding a sensor kinase) as well as yedW; yedVW is one of four copper regulons found in E. coli; part of the copper homeostasis mechanism; confers resistance to copper and several drugs when induced; transcriptional regulatory protein YedW complement(2737905..2738576) Escherichia coli O157:H7 str. EDL933 961973 NP_288429.1 CDS Z3062 NC_002655.2 2738710 2739123 D hypothetical protein 2738710..2739123 Escherichia coli O157:H7 str. EDL933 961974 NP_288430.1 CDS Z3063 NC_002655.2 2739231 2740235 D in Escherichia coli this periplasmic enzyme was found to encode the periplasmic catalytic subunit of an oxidoreductase; sulfite oxidase activity not demonstrated; requires inner membrane anchor protein YedZ; sulfite oxidase subunit YedY 2739231..2740235 Escherichia coli O157:H7 str. EDL933 961975 NP_288431.1 CDS Z3064 NC_002655.2 2740236 2740871 D in Escherichia coli this inner membrane protein was found to anchor the periplasmic catalytic oxidoreductase YedY; sulfite oxidase activity not demonstrated; contains heme; sulfite oxidase subunit YedZ 2740236..2740871 Escherichia coli O157:H7 str. EDL933 961976 NP_288432.1 CDS Z3065 NC_002655.2 2741128 2741778 D hypothetical protein 2741128..2741778 Escherichia coli O157:H7 str. EDL933 961977 NP_288433.1 CDS Z3066 NC_002655.2 2741888 2742037 D No significant matches; hypothetical protein 2741888..2742037 Escherichia coli O157:H7 str. EDL933 961978 NP_288434.1 CDS yodB NC_002655.2 2742091 2742651 D cytochrome 2742091..2742651 Escherichia coli O157:H7 str. EDL933 961979 NP_288435.1 CDS Z3069 NC_002655.2 2743223 2743582 D No significant matches; hypothetical protein 2743223..2743582 Escherichia coli O157:H7 str. EDL933 961980 NP_288436.1 CDS Z3071 NC_002655.2 2743790 2744443 D No significant matches; hypothetical protein 2743790..2744443 Escherichia coli O157:H7 str. EDL933 961981 NP_288437.1 CDS Z3072 NC_002655.2 2744768 2745922 D hypothetical protein 2744768..2745922 Escherichia coli O157:H7 str. EDL933 961982 NP_288438.1 CDS Z3073 NC_002655.2 2746048 2746317 R hypothetical protein complement(2746048..2746317) Escherichia coli O157:H7 str. EDL933 961983 NP_288439.1 CDS Z3074 NC_002655.2 2746319 2747638 R tail fiber protein of prophage CP-933U complement(2746319..2747638) Escherichia coli O157:H7 str. EDL933 961984 NP_288440.1 CDS lomU NC_002655.2 2747697 2748296 R prophage protein complement(2747697..2748296) Escherichia coli O157:H7 str. EDL933 961985 NP_288441.1 CDS Z3077 NC_002655.2 2748365 2751844 R tail fiber component J of prophage CP-933U complement(2748365..2751844) Escherichia coli O157:H7 str. EDL933 961986 NP_288442.1 CDS Z3079 NC_002655.2 2752085 2752621 R tail fiber component I of prophage CP-933U complement(2752085..2752621) Escherichia coli O157:H7 str. EDL933 961987 NP_288443.1 CDS Z3081 NC_002655.2 2752660 2753541 R tail fiber component K of prophage CP-933U complement(2752660..2753541) Escherichia coli O157:H7 str. EDL933 961988 NP_288444.1 CDS Z3082 NC_002655.2 2753414 2754112 R tail fiber component L of prophage CP-933U complement(2753414..2754112) Escherichia coli O157:H7 str. EDL933 961989 NP_288445.1 CDS Z3083 NC_002655.2 2754112 2754441 R tail fiber component M of prophage CP-933U complement(2754112..2754441) Escherichia coli O157:H7 str. EDL933 961990 NP_288446.1 CDS Z3084 NC_002655.2 2754438 2757092 R tail fiber component H of prophage CP-933U complement(2754438..2757092) Escherichia coli O157:H7 str. EDL933 961991 NP_288447.1 CDS Z3085 NC_002655.2 2757127 2757435 R tail fiber component T of prophage CP-933U complement(2757127..2757435) Escherichia coli O157:H7 str. EDL933 961992 NP_288448.1 CDS Z3086 NC_002655.2 2757462 2757884 R tail fiber component G of prophage CP-933U complement(2757462..2757884) Escherichia coli O157:H7 str. EDL933 961993 NP_288449.1 CDS Z3087 NC_002655.2 2757898 2758650 R tail fiber component V of prophage CP-933U complement(2757898..2758650) Escherichia coli O157:H7 str. EDL933 961994 NP_288450.1 CDS Z3088 NC_002655.2 2758658 2759056 R tail fiber component U of prophage CP-933U complement(2758658..2759056) Escherichia coli O157:H7 str. EDL933 961995 NP_288451.1 CDS Z3089 NC_002655.2 2759069 2759698 R tail fiber component Z of prophage CP-933U complement(2759069..2759698) Escherichia coli O157:H7 str. EDL933 961996 NP_288452.1 CDS Z3090 NC_002655.2 2759695 2759976 R No significant matches; hypothetical protein complement(2759695..2759976) Escherichia coli O157:H7 str. EDL933 961997 NP_288453.1 CDS Z3091 NC_002655.2 2759969 2760295 R No significant matches; hypothetical protein complement(2759969..2760295) Escherichia coli O157:H7 str. EDL933 961998 NP_288454.1 CDS Z3092 NC_002655.2 2760383 2761423 R No significant matches; hypothetical protein complement(2760383..2761423) Escherichia coli O157:H7 str. EDL933 961999 NP_288455.1 CDS Z3093 NC_002655.2 2761545 2761871 D hypothetical protein 2761545..2761871 Escherichia coli O157:H7 str. EDL933 962000 NP_288456.1 CDS Z3095 NC_002655.2 2761893 2762759 D transposase encoded within prophage CP-933U 2761893..2762759 Escherichia coli O157:H7 str. EDL933 962001 NP_288457.1 CDS Z3097 NC_002655.2 2762762 2763721 R peptidase encoded within prophage CP-933U complement(2762762..2763721) Escherichia coli O157:H7 str. EDL933 962002 NP_288458.1 CDS Z3098 NC_002655.2 2763666 2765168 R head-tail preconnector protein of prophage CP-933U complement(2763666..2765168) Escherichia coli O157:H7 str. EDL933 962003 NP_288459.1 CDS Z3099 NC_002655.2 2765377 2767389 R DNA packaging protein of prophage CP-933U complement(2765377..2767389) Escherichia coli O157:H7 str. EDL933 962004 NP_288460.1 CDS Z3100 NC_002655.2 2767497 2767973 R No significant matches; hypothetical protein complement(2767497..2767973) Escherichia coli O157:H7 str. EDL933 962005 NP_288461.1 CDS Z3101 NC_002655.2 2768428 2768895 R endopeptidase of prophage CP-933U complement(2768428..2768895) Escherichia coli O157:H7 str. EDL933 962006 NP_288462.1 CDS antU NC_002655.2 2769049 2769618 R No significant matches; antirepressor protein of prophage CP-933U complement(2769049..2769618) Escherichia coli O157:H7 str. EDL933 962007 NP_288463.1 CDS Z3104 NC_002655.2 2769889 2770422 R endolysin of prophage CP-933U complement(2769889..2770422) Escherichia coli O157:H7 str. EDL933 962008 NP_288464.1 CDS Z3105 NC_002655.2 2770473 2770820 R hypothetical protein complement(2770473..2770820) Escherichia coli O157:H7 str. EDL933 962009 NP_288465.1 CDS Z3106 NC_002655.2 2770822 2771136 R holin protein of prophage CP-933U complement(2770822..2771136) Escherichia coli O157:H7 str. EDL933 962010 NP_288466.1 CDS Z3107 NC_002655.2 2771187 2773040 R hypothetical protein complement(2771187..2773040) Escherichia coli O157:H7 str. EDL933 962011 NP_288467.1 CDS Z3108 NC_002655.2 2773354 2773521 R No significant matches; hypothetical protein complement(2773354..2773521) Escherichia coli O157:H7 str. EDL933 962012 NP_288468.1 CDS Z3109 NC_002655.2 2773518 2773937 R hypothetical protein complement(2773518..2773937) Escherichia coli O157:H7 str. EDL933 962013 NP_288469.1 CDS Z3114 NC_002655.2 2774580 2775269 R antitermination protein Q complement(2774580..2775269) Escherichia coli O157:H7 str. EDL933 962017 NP_288470.1 CDS Z3115 NC_002655.2 2775266 2775625 R endonuclease encoded within prophage CP-933U complement(2775266..2775625) Escherichia coli O157:H7 str. EDL933 962018 NP_288471.1 CDS Z3116 NC_002655.2 2775638 2776687 R hypothetical protein complement(2775638..2776687) Escherichia coli O157:H7 str. EDL933 962019 NP_288472.1 CDS Z3117 NC_002655.2 2776770 2777093 D No significant matches; hypothetical protein 2776770..2777093 Escherichia coli O157:H7 str. EDL933 962020 NP_288473.1 CDS Z3118 NC_002655.2 2777534 2777638 R No significant matches; hypothetical protein complement(2777534..2777638) Escherichia coli O157:H7 str. EDL933 962021 NP_288474.1 CDS Z3119 NC_002655.2 2777748 2778311 R hypothetical protein complement(2777748..2778311) Escherichia coli O157:H7 str. EDL933 962022 NP_288475.1 CDS Z3120 NC_002655.2 2778438 2778749 R No significant matches; hypothetical protein complement(2778438..2778749) Escherichia coli O157:H7 str. EDL933 962023 NP_288476.1 CDS Z3121 NC_002655.2 2778931 2779287 R No significant matches; hypothetical protein complement(2778931..2779287) Escherichia coli O157:H7 str. EDL933 962024 NP_288477.1 CDS Z3122 NC_002655.2 2779530 2780294 R hypothetical protein complement(2779530..2780294) Escherichia coli O157:H7 str. EDL933 962025 NP_288478.1 CDS Z3123 NC_002655.2 2780263 2780925 R hypothetical protein complement(2780263..2780925) Escherichia coli O157:H7 str. EDL933 962026 NP_288479.1 CDS Z3124 NC_002655.2 2780717 2781754 R hypothetical protein complement(2780717..2781754) Escherichia coli O157:H7 str. EDL933 962027 NP_288480.1 CDS Z3125 NC_002655.2 2781823 2782248 R hypothetical protein complement(2781823..2782248) Escherichia coli O157:H7 str. EDL933 962028 NP_288481.1 CDS Z3126 NC_002655.2 2782567 2783157 D repressor protein of prophage CP-933U 2782567..2783157 Escherichia coli O157:H7 str. EDL933 962029 NP_288482.1 CDS Z3127 NC_002655.2 2783489 2783641 D hypothetical protein 2783489..2783641 Escherichia coli O157:H7 str. EDL933 962030 NP_288483.1 CDS Z3128 NC_002655.2 2784122 2784310 D inhibitor of cell division encoded within prophage CP-933U 2784122..2784310 Escherichia coli O157:H7 str. EDL933 962031 NP_288484.1 CDS exoU NC_002655.2 2784593 2787064 D exodeoxyribonuclease VIII 2784593..2787064 Escherichia coli O157:H7 str. EDL933 962032 NP_288485.1 CDS intU NC_002655.2 2787326 2788348 D integrase for prophage CP-933U 2787326..2788348 Escherichia coli O157:H7 str. EDL933 962033 NP_288486.1 CDS Z3132 NC_002655.2 2788545 2789381 D hypothetical protein 2788545..2789381 Escherichia coli O157:H7 str. EDL933 962035 NP_288487.1 CDS Z3135 NC_002655.2 2789871 2797853 D invasin 2789871..2797853 Escherichia coli O157:H7 str. EDL933 962037 NP_288488.1 CDS Z3136 NC_002655.2 2790411 2790656 R No significant matches; hypothetical protein complement(2790411..2790656) Escherichia coli O157:H7 str. EDL933 962038 NP_288489.1 CDS Z3137 NC_002655.2 2798115 2799167 R hypothetical protein complement(2798115..2799167) Escherichia coli O157:H7 str. EDL933 962039 NP_288490.1 CDS shiA NC_002655.2 2799481 2800797 D shikimate transporter 2799481..2800797 Escherichia coli O157:H7 str. EDL933 962040 NP_288491.1 CDS amn NC_002655.2 2800899 2802353 D Catalyzes the hydrolysis of AMP to form adenine and ribose 5-phosphate using water as the nucleophile; AMP nucleosidase 2800899..2802353 Escherichia coli O157:H7 str. EDL933 962041 NP_288492.1 CDS Z3140 NC_002655.2 2802696 2803412 D hypothetical protein 2802696..2803412 Escherichia coli O157:H7 str. EDL933 962042 NP_288493.1 CDS Z3143 NC_002655.2 2804038 2804361 R hypothetical protein complement(2804038..2804361) Escherichia coli O157:H7 str. EDL933 962044 NP_288494.2 CDS Z3144 NC_002655.2 2804386 2805678 R hypothetical protein complement(2804386..2805678) Escherichia coli O157:H7 str. EDL933 962045 NP_288495.1 CDS cbl NC_002655.2 2805799 2806749 R LysR-type transcriptional regulator similar to CysB; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates two operons consisting of ABC transporters that are part of the cys regulon; regulated by CysB; transcriptional regulator Cbl complement(2805799..2806749) Escherichia coli O157:H7 str. EDL933 962047 NP_288496.1 CDS nac NC_002655.2 2806851 2807768 R Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation; nitrogen assimilation transcriptional regulator complement(2806851..2807768) Escherichia coli O157:H7 str. EDL933 962048 NP_288497.1 CDS erfK NC_002655.2 2808225 2809157 R hypothetical protein complement(2808225..2809157) Escherichia coli O157:H7 str. EDL933 962050 NP_288498.1 CDS cobT NC_002655.2 2809222 2810301 R catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole; nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase complement(2809222..2810301) Escherichia coli O157:H7 str. EDL933 962051 NP_288499.1 CDS cobS NC_002655.2 2810313 2811056 R catalyzes the formation of adenosylcobalamin from Ado-cobinamide-GDP and alpha-ribazole; cobalamin synthase complement(2810313..2811056) Escherichia coli O157:H7 str. EDL933 962052 NP_288500.1 CDS cobU NC_002655.2 2811053 2811598 R catalyzes ATP-dependent phosphorylation of adenosylcobinamide to form adenosylcobinamide phosphate and the addition of guanosine monophosphate to adenosylcobinamide phosphate to form adenosylcobinamide-GDP; adenosylcobinamide kinase complement(2811053..2811598) Escherichia coli O157:H7 str. EDL933 962053 NP_288501.1 CDS Z3154 NC_002655.2 2811939 2812340 D hypothetical protein 2811939..2812340 Escherichia coli O157:H7 str. EDL933 962054 NP_288502.1 CDS Z3155 NC_002655.2 2812337 2812684 D hypothetical protein 2812337..2812684 Escherichia coli O157:H7 str. EDL933 962055 NP_288503.1 CDS Z3156 NC_002655.2 2812734 2814272 D hypothetical protein 2812734..2814272 Escherichia coli O157:H7 str. EDL933 962056 NP_288504.1 CDS Z3159 NC_002655.2 2815709 2817868 D outer membrane receptor for iron compound or colicin 2815709..2817868 Escherichia coli O157:H7 str. EDL933 962057 NP_288505.1 CDS Z3161 NC_002655.2 2818240 2818566 D hypothetical protein 2818240..2818566 Escherichia coli O157:H7 str. EDL933 962058 NP_288506.1 CDS Z3162 NC_002655.2 2818563 2819453 D IS629 transposase 2818563..2819453 Escherichia coli O157:H7 str. EDL933 962059 NP_288507.1 CDS yeeT NC_002655.2 2819535 2819756 D hypothetical protein 2819535..2819756 Escherichia coli O157:H7 str. EDL933 962060 NP_288508.1 CDS yeeU NC_002655.2 2819830 2820198 D structural protein 2819830..2820198 Escherichia coli O157:H7 str. EDL933 962061 NP_288509.1 CDS Z3165 NC_002655.2 2820287 2820550 D hypothetical protein 2820287..2820550 Escherichia coli O157:H7 str. EDL933 962062 NP_288510.1 CDS yeeW NC_002655.2 2820657 2820851 D hypothetical protein 2820657..2820851 Escherichia coli O157:H7 str. EDL933 962063 NP_288511.1 CDS Z3167 NC_002655.2 2821293 2821649 D No significant matches; hypothetical protein 2821293..2821649 Escherichia coli O157:H7 str. EDL933 962064 NP_288512.1 CDS yeeX NC_002655.2 2821750 2822145 R hypothetical protein complement(2821750..2822145) Escherichia coli O157:H7 str. EDL933 962065 NP_288513.1 CDS yeeA NC_002655.2 2822251 2823309 R hypothetical protein complement(2822251..2823309) Escherichia coli O157:H7 str. EDL933 962066 NP_288514.1 CDS sbmC NC_002655.2 2823508 2823981 R DNA gyrase inhibitor complement(2823508..2823981) Escherichia coli O157:H7 str. EDL933 962067 NP_288515.1 CDS dacD NC_002655.2 2824100 2825272 R removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; penicillin-binding protein 6B; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains; D-alanyl-D-alanine carboxypeptidase complement(2824100..2825272) Escherichia coli O157:H7 str. EDL933 962068 NP_288516.2 CDS sbcB NC_002655.2 2825476 2826903 D Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates; exonuclease I 2825476..2826903 Escherichia coli O157:H7 str. EDL933 962069 NP_288517.1 CDS yeeD NC_002655.2 2826946 2827173 R hypothetical protein complement(2826946..2827173) Escherichia coli O157:H7 str. EDL933 962070 NP_288518.1 CDS yeeE NC_002655.2 2827187 2828245 R transport system permease complement(2827187..2828245) Escherichia coli O157:H7 str. EDL933 962071 NP_288519.1 CDS yeeF NC_002655.2 2828424 2829788 R amino acid/amine transport protein complement(2828424..2829788) Escherichia coli O157:H7 str. EDL933 962072 NP_288520.1 CDS yeeY NC_002655.2 2830049 2830999 R LysR family transcriptional regulator complement(2830049..2830999) Escherichia coli O157:H7 str. EDL933 962073 NP_288521.1 CDS Z3178 NC_002655.2 2831024 2831848 R enzyme of sugar metabolism complement(2831024..2831848) Escherichia coli O157:H7 str. EDL933 962074 NP_288522.1 CDS Z3179 NC_002655.2 2831921 2832127 D No significant matches; hypothetical protein 2831921..2832127 Escherichia coli O157:H7 str. EDL933 962075 NP_288524.1 CDS hisG NC_002655.2 2832470 2833369 D long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors; ATP phosphoribosyltransferase 2832470..2833369 Escherichia coli O157:H7 str. EDL933 962077 NP_288525.1 CDS hisD NC_002655.2 2833375 2834679 D catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer; histidinol dehydrogenase 2833375..2834679 Escherichia coli O157:H7 str. EDL933 962078 NP_288526.1 CDS hisC NC_002655.2 2834676 2835746 D catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; histidinol-phosphate aminotransferase 2834676..2835746 Escherichia coli O157:H7 str. EDL933 962079 NP_288527.2 CDS hisB NC_002655.2 2835746 2836813 D catalyzes the formation of 3-(imidazol-4-yl)-2-oxopropyl phosphate from D-ethythro-1-(imidazol-4-yl)glycerol 3-phosphate and histidinol from histidinol phosphate; imidazole glycerol-phosphate dehydratase/histidinol phosphatase 2835746..2836813 Escherichia coli O157:H7 str. EDL933 962080 NP_288528.1 CDS hisH NC_002655.2 2836813 2837403 D with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide; imidazole glycerol phosphate synthase subunit HisH 2836813..2837403 Escherichia coli O157:H7 str. EDL933 962081 NP_288529.2 CDS hisA NC_002655.2 2837403 2838140 D catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide; 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase 2837403..2838140 Escherichia coli O157:H7 str. EDL933 962082 NP_288530.1 CDS hisF NC_002655.2 2838122 2838898 D catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase; imidazole glycerol phosphate synthase subunit HisF 2838122..2838898 Escherichia coli O157:H7 str. EDL933 962083 NP_288531.1 CDS hisI NC_002655.2 2838892 2839503 D catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis; bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase 2838892..2839503 Escherichia coli O157:H7 str. EDL933 962084 NP_288532.1 CDS wzzB NC_002655.2 2839600 2840613 R regulator of length of O-antigen component of lipopolysaccharide chains complement(2839600..2840613) Escherichia coli O157:H7 str. EDL933 962085 NP_288533.1 CDS ugd NC_002655.2 2840723 2841889 R UDP-glucose 6-dehydrogenase complement(2840723..2841889) Escherichia coli O157:H7 str. EDL933 962086 NP_288534.1 CDS gnd NC_002655.2 2842138 2843544 R catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase complement(2842138..2843544) Escherichia coli O157:H7 str. EDL933 962087 NP_288535.1 CDS wbdR NC_002655.2 2843745 2844410 R acetyl transferase; O-antigen biosynthesis complement(2843745..2844410) Escherichia coli O157:H7 str. EDL933 962088 NP_288536.1 CDS manB NC_002655.2 2845674 2847044 R phosphomannomutase complement(2845674..2847044) Escherichia coli O157:H7 str. EDL933 962089 NP_288537.1 CDS manC NC_002655.2 2847048 2848496 R mannose-1-phosphate guanylyltransferase complement(2847048..2848496) Escherichia coli O157:H7 str. EDL933 962090 NP_288538.1 CDS wbdQ NC_002655.2 2848478 2848987 R GDP-mannose mannosyl hydrolase complement(2848478..2848987) Escherichia coli O157:H7 str. EDL933 962091 NP_288539.1 CDS fcI NC_002655.2 2848990 2849955 R fucose synthetase complement(2848990..2849955) Escherichia coli O157:H7 str. EDL933 962092 NP_288540.1 CDS Z3198 NC_002655.2 2849958 2851076 R GDP-mannose dehydratase complement(2849958..2851076) Escherichia coli O157:H7 str. EDL933 962093 NP_288541.1 CDS wbdP NC_002655.2 2851096 2852310 R glycosyl transferase complement(2851096..2852310) Escherichia coli O157:H7 str. EDL933 962094 NP_288542.1 CDS per NC_002655.2 2852335 2853429 R perosamine synthetase complement(2852335..2853429) Escherichia coli O157:H7 str. EDL933 962095 NP_288543.1 CDS wzx NC_002655.2 2853432 2854823 R O antigen flippase Wzx complement(2853432..2854823) Escherichia coli O157:H7 str. EDL933 962096 NP_288544.1 CDS wbdO NC_002655.2 2854810 2855556 R glycosyl transferase complement(2854810..2855556) Escherichia coli O157:H7 str. EDL933 962097 NP_288545.1 CDS wzy NC_002655.2 2855525 2856709 R O antigen polymerase complement(2855525..2856709) Escherichia coli O157:H7 str. EDL933 962098 NP_288546.1 CDS wbdN NC_002655.2 2856706 2857488 R glycosyl transferase complement(2856706..2857488) Escherichia coli O157:H7 str. EDL933 962099 NP_288547.1 CDS galF NC_002655.2 2857807 2858700 R together with GalU subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose; UTP-glucose-1-phosphate uridylyltransferase complement(2857807..2858700) Escherichia coli O157:H7 str. EDL933 962100 NP_288548.1 CDS Z3206 NC_002655.2 2858943 2859938 R UDP-galactose 4-epimerase complement(2858943..2859938) Escherichia coli O157:H7 str. EDL933 962101 NP_288549.1 CDS wcaM NC_002655.2 2860096 2861490 R WcaM from Salmonella enterica is essential for biofilm formation on HEp-2 cells and chicken intestinal tissue but not on a plastic surface; may be involved in the biosynthesis of colanic acid; colanic acid biosynthesis protein complement(2860096..2861490) Escherichia coli O157:H7 str. EDL933 962102 NP_288550.1 CDS wcaL NC_002655.2 2861501 2862721 R colanic acid biosynthesis glycosyl transferase complement(2861501..2862721) Escherichia coli O157:H7 str. EDL933 962103 NP_288551.1 CDS wcaK NC_002655.2 2862718 2863998 R pyruvyl transferase complement(2862718..2863998) Escherichia coli O157:H7 str. EDL933 962104 NP_288552.1 CDS wzxC NC_002655.2 2864178 2865656 R colanic acid exporter complement(2864178..2865656) Escherichia coli O157:H7 str. EDL933 962105 NP_288553.1 CDS wcaJ NC_002655.2 2865658 2867052 R WcaJ; glucose-1-phosphate transferase responsible for the addition of the first glucose-1-phosphate from UDP-glucose to the lipid carrier undecaprenyl phosphate in the biosynthesis of colanic acid; UDP-glucose lipid carrier transferase complement(2865658..2867052) Escherichia coli O157:H7 str. EDL933 962106 NP_288554.1 CDS cpsG NC_002655.2 2867107 2868477 R phosphomannomutase complement(2867107..2868477) Escherichia coli O157:H7 str. EDL933 962107 NP_288555.1 CDS cpsB NC_002655.2 2868670 2870106 R mannose-1-phosphate guanylyltransferase complement(2868670..2870106) Escherichia coli O157:H7 str. EDL933 962108 NP_288556.1 CDS wcaI NC_002655.2 2870109 2871332 R glycosyl transferase complement(2870109..2871332) Escherichia coli O157:H7 str. EDL933 962109 NP_288557.1 CDS wcaH NC_002655.2 2871329 2871811 R GDP-mannose mannosyl hydrolase complement(2871329..2871811) Escherichia coli O157:H7 str. EDL933 956665 NP_288558.1 CDS wcaG NC_002655.2 2871811 2872776 R nucleotide di-P-sugar epimerase or dehydratase complement(2871811..2872776) Escherichia coli O157:H7 str. EDL933 957230 NP_288559.1 CDS gmd NC_002655.2 2872779 2873900 R GDP-D-mannose dehydratase complement(2872779..2873900) Escherichia coli O157:H7 str. EDL933 957035 NP_288560.1 CDS wcaF NC_002655.2 2873929 2874477 R acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit); colanic acid biosynthesis acetyltransferase WcaF complement(2873929..2874477) Escherichia coli O157:H7 str. EDL933 956732 NP_288561.1 CDS wcaE NC_002655.2 2874493 2875239 R glycosyl transferase complement(2874493..2875239) Escherichia coli O157:H7 str. EDL933 956927 NP_288562.1 CDS wcaD NC_002655.2 2875250 2876467 R essential for colanic acid biosynthesis; colanic acid is an exopolysaccharide produced under stress conditions that confers acid and heat tolerance; colanic acid biosynthesis protein complement(2875250..2876467) Escherichia coli O157:H7 str. EDL933 959508 NP_288563.1 CDS wcaC NC_002655.2 2876442 2877659 R glycosyl transferase complement(2876442..2877659) Escherichia coli O157:H7 str. EDL933 958422 NP_288564.1 CDS wcaB NC_002655.2 2877656 2878144 R acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit); wcaB is induced in sessile bacteria and by osmotic shock, and repressed when grown in rich medium; colanic acid biosynthesis acetyltransferase WcaB complement(2877656..2878144) Escherichia coli O157:H7 str. EDL933 958129 NP_288565.1 CDS wcaA NC_002655.2 2878147 2878986 R glycosyl transferase complement(2878147..2878986) Escherichia coli O157:H7 str. EDL933 956990 NP_288566.2 CDS Z3224 NC_002655.2 2879079 2881241 R Wzc; catalyzes the autophosphorylation on tyrosine residues which downregulates the biosynthesis of colonic acid (an extracellular polysaccharide); tyrosine kinase complement(2879079..2881241) Escherichia coli O157:H7 str. EDL933 956738 NP_288567.1 CDS wzb NC_002655.2 2881244 2881687 R Wzb shows phosphatase activity towards the autophosphorylated Wzc protein, which induces colanic acid biosynthesis; catalyzes the phosphorylation of UDP-glucose dehydrogenase, an enzyme involved in colanic acid biosynthesis; tyrosine phosphatase complement(2881244..2881687) Escherichia coli O157:H7 str. EDL933 956740 NP_288568.1 CDS wza NC_002655.2 2881693 2882832 R polysaccharide export protein complement(2881693..2882832) Escherichia coli O157:H7 str. EDL933 956750 NP_288569.1 CDS yegH NC_002655.2 2883426 2885075 D transporter 2883426..2885075 Escherichia coli O157:H7 str. EDL933 958470 NP_288570.1 CDS Z3230 NC_002655.2 2885150 2885488 D hypothetical protein 2885150..2885488 Escherichia coli O157:H7 str. EDL933 960786 NP_288571.1 CDS Z3231 NC_002655.2 2885478 2885768 D hypothetical protein 2885478..2885768 Escherichia coli O157:H7 str. EDL933 958088 NP_288572.2 CDS asmA NC_002655.2 2885821 2887674 R YegA; inner membrane protein involved in the assembly of outer membrane proteins (OMPs); asmA-null mutants show low lipopolysaccharide (LPS) levels, suggesting a role in LPS biogenesis and/or in restricting outer membrane fluidity, resulting on altered assembly of OMPs; assembly protein complement(2885821..2887674) Escherichia coli O157:H7 str. EDL933 956763 NP_288573.1 CDS dcd NC_002655.2 2887696 2888277 R Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis; deoxycytidine triphosphate deaminase complement(2887696..2888277) Escherichia coli O157:H7 str. EDL933 959524 NP_288574.2 CDS udk NC_002655.2 2888369 2889010 R functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor; uridine kinase complement(2888369..2889010) Escherichia coli O157:H7 str. EDL933 956798 NP_288575.1 CDS Z3235m NC_002655.2 2889330 2892648 D contains a MASE1 (Membrane-Associated Sensor) domain; potentially involved in signal transduction; sensor protein join(2889330..2889785,2889787..2892648) Escherichia coli O157:H7 str. EDL933 959644 NP_288576.1 CDS alkA NC_002655.2 2892749 2893597 R inducible, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine; 3-methyladenine DNA glycosylase complement(2892749..2893597) Escherichia coli O157:H7 str. EDL933 958151 NP_288577.2 CDS yegD NC_002655.2 2893731 2895083 D chaperone 2893731..2895083 Escherichia coli O157:H7 str. EDL933 961423 NP_288578.1 CDS Z3239 NC_002655.2 2895096 2897036 R chaperonin complement(2895096..2897036) Escherichia coli O157:H7 str. EDL933 956769 NP_288579.1 CDS Z3240 NC_002655.2 2897033 2897794 R hypothetical protein complement(2897033..2897794) Escherichia coli O157:H7 str. EDL933 956785 NP_288580.1 CDS Z3241 NC_002655.2 2897791 2898450 R hypothetical protein complement(2897791..2898450) Escherichia coli O157:H7 str. EDL933 956810 NP_288581.1 CDS Z3242 NC_002655.2 2899022 2899168 D No significant matches; hypothetical protein 2899022..2899168 Escherichia coli O157:H7 str. EDL933 956829 NP_288582.2 CDS Z3243 NC_002655.2 2899668 2900915 D Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate; multidrug efflux system subunit MdtA 2899668..2900915 Escherichia coli O157:H7 str. EDL933 956779 NP_288583.1 CDS yegN NC_002655.2 2900915 2904037 D Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate; multidrug efflux system subunit MdtB 2900915..2904037 Escherichia coli O157:H7 str. EDL933 956780 NP_288584.1 CDS yegO NC_002655.2 2904038 2907115 D Part of a tripartite efflux system composed of MdtA, MdtB and MdtC; confers resistance against novobiocin and deoxycholate; multidrug efflux system subunit MdtC 2904038..2907115 Escherichia coli O157:H7 str. EDL933 956783 NP_288585.1 CDS yegB NC_002655.2 2907116 2908531 D multidrug efflux system protein MdtE 2907116..2908531 Escherichia coli O157:H7 str. EDL933 956803 NP_288586.1 CDS baeS NC_002655.2 2908528 2909931 D signal transduction histidine-protein kinase BaeS 2908528..2909931 Escherichia coli O157:H7 str. EDL933 958087 NP_288587.1 CDS baeR NC_002655.2 2909928 2910650 D response regulator in two-component regulatory system with BaeS; regulator of RNA synthesis, flagellar biosynthesis, chemotaxis and transport; DNA-binding transcriptional regulator BaeR 2909928..2910650 Escherichia coli O157:H7 str. EDL933 959577 NP_288588.1 CDS Z3249 NC_002655.2 2910802 2911173 D hypothetical protein 2910802..2911173 Escherichia coli O157:H7 str. EDL933 956806 NP_288589.1 CDS yegQ NC_002655.2 2911321 2912682 D hypothetical protein 2911321..2912682 Escherichia coli O157:H7 str. EDL933 958264 NP_288590.1 CDS Z3251 NC_002655.2 2913012 2913389 R hypothetical protein complement(2913012..2913389) Escherichia coli O157:H7 str. EDL933 957197 NP_288591.1 CDS Z3252 NC_002655.2 2913735 2914634 D cytosolic protein with phosphatidylglycerol kinase activity; undetermined physiological role; lipid kinase 2913735..2914634 Escherichia coli O157:H7 str. EDL933 957780 NP_288592.1 CDS gatR NC_002655.2 2914716 2915162 R galactitol utilization operon repressor complement(2914716..2915162) Escherichia coli O157:H7 str. EDL933 956860 NP_288593.1 CDS gatD NC_002655.2 2915595 2916635 R Zn-dependent; NAD(P)-binding; catalyzes the formation of tagatose-6-phosphate from galactitol-1-phosphate; galactitol-1-phosphate dehydrogenase complement(2915595..2916635) Escherichia coli O157:H7 str. EDL933 956811 NP_288594.1 CDS gatC NC_002655.2 2916683 2918038 R PTS system galactitol-specific enzyme IIC complement(2916683..2918038) Escherichia coli O157:H7 str. EDL933 959443 NP_288595.1 CDS gatB NC_002655.2 2918042 2918326 R phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system galactitol-specific transporter subunit IIB complement(2918042..2918326) Escherichia coli O157:H7 str. EDL933 959320 NP_288596.1 CDS gatA NC_002655.2 2918357 2918809 R phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system galactitol-specific transporter subunit IIA complement(2918357..2918809) Escherichia coli O157:H7 str. EDL933 956751 NP_288597.1 CDS gatZ NC_002655.2 2918819 2920081 R tagatose 6-phosphate kinase 1 complement(2918819..2920081) Escherichia coli O157:H7 str. EDL933 961356 NP_288598.2 CDS gatY NC_002655.2 2920110 2920964 R catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway; tagatose-bisphosphate aldolase complement(2920110..2920964) Escherichia coli O157:H7 str. EDL933 956817 NP_288599.2 CDS Z3260 NC_002655.2 2921263 2922315 R catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate; fructose-bisphosphate aldolase complement(2921263..2922315) Escherichia coli O157:H7 str. EDL933 956818 NP_288600.1 CDS yegT NC_002655.2 2922573 2923850 D nucleoside permease 2922573..2923850 Escherichia coli O157:H7 str. EDL933 956819 NP_288601.1 CDS Z3262 NC_002655.2 2923847 2924851 D hypothetical protein 2923847..2924851 Escherichia coli O157:H7 str. EDL933 956838 NP_288602.1 CDS Z3263 NC_002655.2 2924848 2925813 D kinase 2924848..2925813 Escherichia coli O157:H7 str. EDL933 960980 NP_288603.1 CDS yegW NC_002655.2 2925787 2926533 R transcriptional regulator complement(2925787..2926533) Escherichia coli O157:H7 str. EDL933 956824 NP_288604.1 CDS yegX NC_002655.2 2926585 2927412 R hypothetical protein complement(2926585..2927412) Escherichia coli O157:H7 str. EDL933 956825 NP_288605.1 CDS thiD NC_002655.2 2927468 2928268 R catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase complement(2927468..2928268) Escherichia coli O157:H7 str. EDL933 956831 NP_288606.1 CDS thiM NC_002655.2 2928265 2929053 R catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP; hydroxyethylthiazole kinase complement(2928265..2929053) Escherichia coli O157:H7 str. EDL933 956840 NP_288607.1 CDS Z3269 NC_002655.2 2929387 2929626 D No significant matches; hypothetical protein 2929387..2929626 Escherichia coli O157:H7 str. EDL933 956846 NP_288608.1 CDS Z3270 NC_002655.2 2930190 2930309 R No significant matches; hypothetical protein complement(2930190..2930309) Escherichia coli O157:H7 str. EDL933 961426 NP_288609.1 CDS Z3271 NC_002655.2 2930677 2931024 D No significant matches; hypothetical protein 2930677..2931024 Escherichia coli O157:H7 str. EDL933 961346 NP_288610.1 CDS Z3272 NC_002655.2 2931034 2931348 D No significant matches; hypothetical protein 2931034..2931348 Escherichia coli O157:H7 str. EDL933 956848 NP_288611.1 CDS yohL NC_002655.2 2931458 2931730 R hypothetical protein complement(2931458..2931730) Escherichia coli O157:H7 str. EDL933 957814 NP_288612.1 CDS yohM NC_002655.2 2931851 2932702 D membrane protein conferring nickel and cobalt resistance; nickel/cobalt efflux protein RcnA 2931851..2932702 Escherichia coli O157:H7 str. EDL933 956851 NP_288613.1 CDS Z3275 NC_002655.2 2932740 2933258 D hypothetical protein 2932740..2933258 Escherichia coli O157:H7 str. EDL933 956854 NP_288614.1 CDS Z3276 NC_002655.2 2933340 2934374 R fimbrial protein complement(2933340..2934374) Escherichia coli O157:H7 str. EDL933 957303 NP_288615.1 CDS yehB NC_002655.2 2934385 2936865 R hypothetical protein complement(2934385..2936865) Escherichia coli O157:H7 str. EDL933 958121 NP_288616.1 CDS yehC NC_002655.2 2936881 2937603 R chaperone protein complement(2936881..2937603) Escherichia coli O157:H7 str. EDL933 956856 NP_288617.1 CDS yehD NC_002655.2 2937643 2938185 R fimbrial-like protein complement(2937643..2938185) Escherichia coli O157:H7 str. EDL933 956858 NP_288618.1 CDS yehE NC_002655.2 2938477 2938758 R hypothetical protein complement(2938477..2938758) Escherichia coli O157:H7 str. EDL933 956869 NP_288619.2 CDS mrp NC_002655.2 2939020 2940129 R ATPase complement(2939020..2940129) Escherichia coli O157:H7 str. EDL933 956870 NP_288620.1 CDS metG NC_002655.2 2940261 2942294 D methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 2940261..2942294 Escherichia coli O157:H7 str. EDL933 956881 NP_288621.1 CDS molR_A NC_002655.2 2942435 2943163 D hypothetical protein 2942435..2943163 Escherichia coli O157:H7 str. EDL933 959445 NP_288622.1 CDS molR_B NC_002655.2 2943353 2946244 D hypothetical protein 2943353..2946244 Escherichia coli O157:H7 str. EDL933 959384 NP_288623.1 CDS molR_C NC_002655.2 2946257 2947537 D hypothetical protein 2946257..2947537 Escherichia coli O157:H7 str. EDL933 956672 NP_288624.1 CDS molR_D NC_002655.2 2947503 2949242 D hypothetical protein 2947503..2949242 Escherichia coli O157:H7 str. EDL933 956882 NP_288625.1 CDS yehI NC_002655.2 2949252 2952881 D regulator 2949252..2952881 Escherichia coli O157:H7 str. EDL933 956885 NP_288626.1 CDS yehK NC_002655.2 2952943 2953260 D hypothetical protein 2952943..2953260 Escherichia coli O157:H7 str. EDL933 956886 NP_288629.1 CDS yehL NC_002655.2 2954435 2955589 D hypothetical protein 2954435..2955589 Escherichia coli O157:H7 str. EDL933 956890 NP_288630.1 CDS Z3292 NC_002655.2 2955600 2957129 D hypothetical protein 2955600..2957129 Escherichia coli O157:H7 str. EDL933 956901 NP_288631.1 CDS Z3293 NC_002655.2 2957148 2957879 D hypothetical protein 2957148..2957879 Escherichia coli O157:H7 str. EDL933 959414 NP_288632.1 CDS yehP NC_002655.2 2957872 2959008 D hypothetical protein 2957872..2959008 Escherichia coli O157:H7 str. EDL933 956826 NP_288633.1 CDS yehQ NC_002655.2 2959005 2961242 D hypothetical protein 2959005..2961242 Escherichia coli O157:H7 str. EDL933 959372 NP_288634.1 CDS Z3297 NC_002655.2 2961049 2961939 R transposase for IS629 complement(2961049..2961939) Escherichia coli O157:H7 str. EDL933 956904 NP_288635.1 CDS Z3299 NC_002655.2 2961936 2962262 R hypothetical protein complement(2961936..2962262) Escherichia coli O157:H7 str. EDL933 956905 NP_288636.1 CDS yehR NC_002655.2 2962434 2962907 D hypothetical protein 2962434..2962907 Escherichia coli O157:H7 str. EDL933 956908 NP_288637.1 CDS yehS NC_002655.2 2962949 2963419 R hypothetical protein complement(2962949..2963419) Escherichia coli O157:H7 str. EDL933 957157 NP_288638.1 CDS yehT NC_002655.2 2963466 2964200 R unknown function; when overproduced it confers drug-resistance; two-component response-regulatory protein YehT complement(2963466..2964200) Escherichia coli O157:H7 str. EDL933 959558 NP_288639.1 CDS yehU NC_002655.2 2964182 2965867 R 2-component sensor protein complement(2964182..2965867) Escherichia coli O157:H7 str. EDL933 956913 NP_288640.1 CDS Z3305 NC_002655.2 2966382 2966630 D hypothetical protein 2966382..2966630 Escherichia coli O157:H7 str. EDL933 956918 NP_288641.1 CDS Z3306 NC_002655.2 2966998 2967267 R hypothetical protein complement(2966998..2967267) Escherichia coli O157:H7 str. EDL933 956920 NP_288642.1 CDS Z3307 NC_002655.2 2967269 2967547 R tail fiber protein encoded within prophage CP-933V complement(2967269..2967547) Escherichia coli O157:H7 str. EDL933 956923 NP_288643.1 CDS Z3309 NC_002655.2 2967774 2968589 R tail fiber protein encoded within prophage CP-933V complement(2967774..2968589) Escherichia coli O157:H7 str. EDL933 956925 NP_288644.1 CDS Z3310 NC_002655.2 2968648 2969247 R Lom-like outer membrane protein of prophage CP-933V complement(2968648..2969247) Escherichia coli O157:H7 str. EDL933 960805 NP_288645.1 CDS Z3311 NC_002655.2 2969318 2972815 R tail fiber protein of prophage CP-933V complement(2969318..2972815) Escherichia coli O157:H7 str. EDL933 958961 NP_288646.1 CDS Z3312 NC_002655.2 2972490 2973476 D superoxide dismutase 2972490..2973476 Escherichia coli O157:H7 str. EDL933 957692 NP_288647.1 CDS Z3313 NC_002655.2 2973667 2974347 R tail component of prophage CP-933V complement(2973667..2974347) Escherichia coli O157:H7 str. EDL933 958214 NP_288648.1 CDS Z3314 NC_002655.2 2974245 2974919 R tail component of prophage CP-933V complement(2974245..2974919) Escherichia coli O157:H7 str. EDL933 956926 NP_288649.1 CDS Z3315 NC_002655.2 2974999 2975697 R tail component of prophage CP-933V complement(2974999..2975697) Escherichia coli O157:H7 str. EDL933 959525 NP_288650.1 CDS Z3316 NC_002655.2 2976031 2976207 R No significant matches; hypothetical protein complement(2976031..2976207) Escherichia coli O157:H7 str. EDL933 956924 NP_288651.1 CDS Z3318 NC_002655.2 2976204 2979113 R tail component of prophage CP-933V complement(2976204..2979113) Escherichia coli O157:H7 str. EDL933 957148 NP_288652.1 CDS Z3319 NC_002655.2 2979166 2979447 R hypothetical protein complement(2979166..2979447) Escherichia coli O157:H7 str. EDL933 956929 NP_288653.1 CDS Z3320 NC_002655.2 2979471 2979845 R hypothetical protein complement(2979471..2979845) Escherichia coli O157:H7 str. EDL933 956933 NP_288654.1 CDS Z3322 NC_002655.2 2979851 2980696 R major tail subunit encoded within prophage CP-933V complement(2979851..2980696) Escherichia coli O157:H7 str. EDL933 956998 NP_288655.1 CDS Z3323 NC_002655.2 2980626 2980970 R hypothetical protein complement(2980626..2980970) Escherichia coli O157:H7 str. EDL933 959606 NP_288656.1 CDS Z3325 NC_002655.2 2980967 2981413 R hypothetical protein complement(2980967..2981413) Escherichia coli O157:H7 str. EDL933 956937 NP_288657.1 CDS Z3326 NC_002655.2 2981410 2981760 R hypothetical protein complement(2981410..2981760) Escherichia coli O157:H7 str. EDL933 956949 NP_288658.1 CDS Z3327 NC_002655.2 2981770 2982096 R No significant matches; hypothetical protein complement(2981770..2982096) Escherichia coli O157:H7 str. EDL933 956951 NP_288659.1 CDS Z3328 NC_002655.2 2982093 2984678 R portal protein for prophage CP-933V complement(2982093..2984678) Escherichia coli O157:H7 str. EDL933 959455 NP_288660.1 CDS Z3329 NC_002655.2 2984624 2984845 R No significant matches; hypothetical protein complement(2984624..2984845) Escherichia coli O157:H7 str. EDL933 958114 NP_288661.1 CDS Z3331 NC_002655.2 2984890 2986827 R hypothetical protein complement(2984890..2986827) Escherichia coli O157:H7 str. EDL933 957098 NP_288662.1 CDS Z3332 NC_002655.2 2986891 2988552 R hypothetical protein complement(2986891..2988552) Escherichia coli O157:H7 str. EDL933 957299 NP_288663.2 CDS Z3333 NC_002655.2 2988549 2989112 R No significant matches; hypothetical protein complement(2988549..2989112) Escherichia coli O157:H7 str. EDL933 956954 NP_288664.1 CDS Z3334 NC_002655.2 2989505 2989750 D No significant matches; hypothetical protein 2989505..2989750 Escherichia coli O157:H7 str. EDL933 956955 NP_288665.1 CDS Z3335 NC_002655.2 2989810 2990037 D hypothetical protein 2989810..2990037 Escherichia coli O157:H7 str. EDL933 956957 NP_288666.2 CDS Z3336 NC_002655.2 2990402 2990869 R endopeptidase Rz for prophage CP-933V complement(2990402..2990869) Escherichia coli O157:H7 str. EDL933 956965 NP_288667.1 CDS antV NC_002655.2 2991023 2991592 R antirepressor of prophage CP-933V complement(2991023..2991592) Escherichia coli O157:H7 str. EDL933 956718 NP_288668.1 CDS Z3339 NC_002655.2 2991863 2992396 R No significant matches; endolysin R of prophage CP-933V complement(2991863..2992396) Escherichia coli O157:H7 str. EDL933 958284 NP_288669.1 CDS Z3340 NC_002655.2 2992401 2992673 R lysis protein S of prophage CP-933V complement(2992401..2992673) Escherichia coli O157:H7 str. EDL933 959522 NP_288670.1 CDS Z3341 NC_002655.2 2992694 2993113 R hypothetical protein complement(2992694..2993113) Escherichia coli O157:H7 str. EDL933 956966 NP_288671.1 CDS Z3342 NC_002655.2 2993297 2995243 R hypothetical protein complement(2993297..2995243) Escherichia coli O157:H7 str. EDL933 958100 NP_288672.1 CDS stx1B NC_002655.2 2995754 2996023 R shiga-like toxin 1 subunit B encoded within prophage CP-933V complement(2995754..2996023) Escherichia coli O157:H7 str. EDL933 956702 NP_288673.1 CDS stx1A NC_002655.2 2996033 2996980 R shiga-like toxin 1 subunit A encoded within prophage CP-933V complement(2996033..2996980) Escherichia coli O157:H7 str. EDL933 956968 NP_288674.1 CDS Z3345 NC_002655.2 2997487 2997921 R antitermination protein Q for prophage CP-933V complement(2997487..2997921) Escherichia coli O157:H7 str. EDL933 956970 NP_288675.1 CDS Z3346 NC_002655.2 2998105 2998710 R hypothetical protein complement(2998105..2998710) Escherichia coli O157:H7 str. EDL933 956976 NP_288676.1 CDS Z3347 NC_002655.2 2998703 2998777 R hypothetical protein complement(2998703..2998777) Escherichia coli O157:H7 str. EDL933 961324 NP_288677.1 CDS Z3348 NC_002655.2 2998872 2999303 R No significant matches; hypothetical protein complement(2998872..2999303) Escherichia coli O157:H7 str. EDL933 956687 NP_288678.1 CDS Z3349 NC_002655.2 2999449 2999976 R DNA methyltransferase encoded within prophage CP-933V complement(2999449..2999976) Escherichia coli O157:H7 str. EDL933 956991 NP_288679.1 CDS Z3351 NC_002655.2 2999973 3000419 R hypothetical protein complement(2999973..3000419) Escherichia coli O157:H7 str. EDL933 956992 NP_288680.1 CDS Z3352 NC_002655.2 3000443 3000802 R hypothetical protein complement(3000443..3000802) Escherichia coli O157:H7 str. EDL933 957004 NP_288681.1 CDS Z3353 NC_002655.2 3000972 3001250 R hypothetical protein complement(3000972..3001250) Escherichia coli O157:H7 str. EDL933 957007 NP_288682.1 CDS Z3354 NC_002655.2 3001321 3001611 R No significant matches; exclusion protein ren of prophage CP-933V complement(3001321..3001611) Escherichia coli O157:H7 str. EDL933 957013 NP_288683.1 CDS Z3355 NC_002655.2 3001608 3002309 R DNA replication protein P of prophage CP-933V complement(3001608..3002309) Escherichia coli O157:H7 str. EDL933 958844 NP_288684.1 CDS Z3356 NC_002655.2 3002306 3003244 R DNA replication protein O of prophage CP-933V complement(3002306..3003244) Escherichia coli O157:H7 str. EDL933 957881 NP_288685.1 CDS Z3357 NC_002655.2 3003277 3003573 R regulatory protein CII of prophage CP-933V complement(3003277..3003573) Escherichia coli O157:H7 str. EDL933 957015 NP_288686.1 CDS Z3358 NC_002655.2 3004015 3004662 D repressor protein CI of prophage CP-933V 3004015..3004662 Escherichia coli O157:H7 str. EDL933 961320 NP_288687.1 CDS Z3359 NC_002655.2 3004785 3004892 D No significant matches; hypothetical protein 3004785..3004892 Escherichia coli O157:H7 str. EDL933 959494 NP_288688.1 CDS Z3360 NC_002655.2 3005074 3005625 D No significant matches; hypothetical protein 3005074..3005625 Escherichia coli O157:H7 str. EDL933 960216 NP_288689.1 CDS Z3361 NC_002655.2 3006138 3006410 D transcription antitermination protein N of prophage CP-933V 3006138..3006410 Escherichia coli O157:H7 str. EDL933 959309 NP_288690.1 CDS Z3362 NC_002655.2 3006548 3007009 R superinfection exclusion protein B of prophage CP-933V complement(3006548..3007009) Escherichia coli O157:H7 str. EDL933 957017 NP_288691.1 CDS Z3363 NC_002655.2 3007270 3007638 D ssDNA-binding protein 3007270..3007638 Escherichia coli O157:H7 str. EDL933 958548 NP_288692.1 CDS Z3364 NC_002655.2 3007718 3007987 D host killing protein Kil of prophage CP-933V 3007718..3007987 Escherichia coli O157:H7 str. EDL933 958550 NP_288693.1 CDS Z3365 NC_002655.2 3008063 3008359 D host-nuclease inhibitor protein Gam of prophage CP-933V 3008063..3008359 Escherichia coli O157:H7 str. EDL933 957029 NP_288694.1 CDS Z3366 NC_002655.2 3008365 3009150 D recombination protein Bet of prophage CP-933V 3008365..3009150 Escherichia coli O157:H7 str. EDL933 959532 NP_288695.1 CDS Z3367 NC_002655.2 3009147 3009824 D exonuclease of prophage CP-933V 3009147..3009824 Escherichia coli O157:H7 str. EDL933 959500 NP_288696.1 CDS Z3368 NC_002655.2 3009979 3010170 D hypothetical protein 3009979..3010170 Escherichia coli O157:H7 str. EDL933 957000 NP_288697.1 CDS Z3369 NC_002655.2 3010181 3010462 D hypothetical protein 3010181..3010462 Escherichia coli O157:H7 str. EDL933 957033 NP_288698.1 CDS Z3370 NC_002655.2 3010779 3011726 D hypothetical protein 3010779..3011726 Escherichia coli O157:H7 str. EDL933 957042 NP_288699.1 CDS Z3371 NC_002655.2 3012238 3012594 D hypothetical protein 3012238..3012594 Escherichia coli O157:H7 str. EDL933 956994 NP_288700.1 CDS Z3372 NC_002655.2 3012591 3012953 D hypothetical protein 3012591..3012953 Escherichia coli O157:H7 str. EDL933 961175 NP_288701.1 CDS Z3373 NC_002655.2 3013095 3013283 D No significant matches; hypothetical protein 3013095..3013283 Escherichia coli O157:H7 str. EDL933 956963 NP_288702.1 CDS Z3374 NC_002655.2 3013287 3013421 D No significant matches; hypothetical protein 3013287..3013421 Escherichia coli O157:H7 str. EDL933 957053 NP_288703.1 CDS intV NC_002655.2 3013728 3015014 D integrase for prophage CP-933V 3013728..3015014 Escherichia coli O157:H7 str. EDL933 956722 NP_288704.1 CDS yehV NC_002655.2 3015089 3015736 D transcriptional regulator 3015089..3015736 Escherichia coli O157:H7 str. EDL933 960500 NP_288705.1 CDS yehW NC_002655.2 3015884 3016615 R transport system permease complement(3015884..3016615) Escherichia coli O157:H7 str. EDL933 957747 NP_288706.1 CDS yehX NC_002655.2 3016620 3017546 R ABC transporter ATP-binding protein complement(3016620..3017546) Escherichia coli O157:H7 str. EDL933 957426 NP_288707.1 CDS yehY NC_002655.2 3017539 3018696 R transport system permease complement(3017539..3018696) Escherichia coli O157:H7 str. EDL933 957055 NP_288708.1 CDS yehZ NC_002655.2 3018703 3019620 R transport system permease complement(3018703..3019620) Escherichia coli O157:H7 str. EDL933 959451 NP_288709.1 CDS bglX NC_002655.2 3019872 3022169 R beta-D-glucoside glucohydrolase complement(3019872..3022169) Escherichia coli O157:H7 str. EDL933 957679 NP_288710.1 CDS dld NC_002655.2 3022365 3024080 D component of the membrane-bound D-lactate oxidase, FAD-binding, NADH independent; D-lactate dehydrogenase 3022365..3024080 Escherichia coli O157:H7 str. EDL933 957060 NP_288711.1 CDS pbpG NC_002655.2 3024118 3025059 R specifically hydrolyze the DD-diaminopimelate-alanine bonds in high-molecular-mass murein sacculi; Penicillin-binding protein 7; D-alanyl-D-alanine endopeptidase complement(3024118..3025059) Escherichia coli O157:H7 str. EDL933 961422 NP_288712.1 CDS yohC NC_002655.2 3025224 3025835 R hypothetical protein complement(3025224..3025835) Escherichia coli O157:H7 str. EDL933 957376 NP_288713.1 CDS yohD NC_002655.2 3025945 3026559 D hypothetical protein 3025945..3026559 Escherichia coli O157:H7 str. EDL933 957247 NP_288714.1 CDS yohF NC_002655.2 3026689 3027450 R acetoin dehydrogenase complement(3026689..3027450) Escherichia coli O157:H7 str. EDL933 957061 NP_288715.4 CDS yohG NC_002655.2 3027503 3028939 R may be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; multidrug resistance outer membrane protein MdtQ complement(3027503..3028939) Escherichia coli O157:H7 str. EDL933 957062 NP_288716.1 CDS Z3388 NC_002655.2 3029283 3029375 R No significant matches; hypothetical protein complement(3029283..3029375) Escherichia coli O157:H7 str. EDL933 959452 NP_288717.1 CDS yohI NC_002655.2 3029633 3030583 R tRNA-dihydrouridine synthase C complement(3029633..3030583) Escherichia coli O157:H7 str. EDL933 957879 NP_288718.1 CDS Z3390 NC_002655.2 3030743 3031936 R catalyzes the formation of catechol from salicylate; salicylate hydroxylase complement(3030743..3031936) Escherichia coli O157:H7 str. EDL933 957065 NP_288719.1 CDS Z3391 NC_002655.2 3031951 3032598 R glutathione-S-transferase complement(3031951..3032598) Escherichia coli O157:H7 str. EDL933 957070 NP_288720.1 CDS Z3392 NC_002655.2 3032604 3033305 R isomerase-decarboxylase complement(3032604..3033305) Escherichia coli O157:H7 str. EDL933 957074 NP_288721.1 CDS Z3393 NC_002655.2 3033320 3034348 R 1,2-dioxygenase complement(3033320..3034348) Escherichia coli O157:H7 str. EDL933 957071 NP_288722.1 CDS Z3394 NC_002655.2 3034360 3035718 R transporter complement(3034360..3035718) Escherichia coli O157:H7 str. EDL933 959392 NP_288723.1 CDS Z3395 NC_002655.2 3035797 3036753 D regulator 3035797..3036753 Escherichia coli O157:H7 str. EDL933 957075 NP_288724.1 CDS yohJ NC_002655.2 3036884 3037282 D hypothetical protein 3036884..3037282 Escherichia coli O157:H7 str. EDL933 957077 NP_288725.1 CDS yohK NC_002655.2 3037279 3037974 D hypothetical protein 3037279..3037974 Escherichia coli O157:H7 str. EDL933 957079 NP_288726.2 CDS cdd NC_002655.2 3038104 3038988 D Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; cytidine deaminase 3038104..3038988 Escherichia coli O157:H7 str. EDL933 957083 NP_288727.1 CDS sanA NC_002655.2 3039138 3039857 D hypothetical protein 3039138..3039857 Escherichia coli O157:H7 str. EDL933 957084 NP_288728.1 CDS Z3400 NC_002655.2 3039860 3040099 D hypothetical protein 3039860..3040099 Escherichia coli O157:H7 str. EDL933 957105 NP_288729.1 CDS Z3401 NC_002655.2 3040293 3041531 D function undetermined; similar to glutamate synthase beta subunit and related oxidoreductases which transfer electrons from NADPH to an acceptor protein or protein domain; oxidoreductase 3040293..3041531 Escherichia coli O157:H7 str. EDL933 957019 NP_288730.2 CDS yeiA NC_002655.2 3041525 3042760 D catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines; dihydropyrimidine dehydrogenase 3041525..3042760 Escherichia coli O157:H7 str. EDL933 956984 NP_288731.1 CDS mglC NC_002655.2 3043004 3044014 R ABC transporter; functions in galactose transport; part of MglA2C2B transporter complex; beta-methylgalactoside transporter inner membrane protein complement(3043004..3044014) Escherichia coli O157:H7 str. EDL933 957108 NP_288732.1 CDS mglA NC_002655.2 3044030 3045550 R with MglBC transports galactose or methyl galactoside into the cell; contains 2 ATP binding domains; galactose/methyl galaxtoside transporter ATP-binding protein complement(3044030..3045550) Escherichia coli O157:H7 str. EDL933 957113 NP_288733.1 CDS mglB NC_002655.2 3045611 3046609 R galactose-binding transport protein; receptor for galactose taxis complement(3045611..3046609) Escherichia coli O157:H7 str. EDL933 959466 NP_288734.1 CDS galS NC_002655.2 3046889 3047929 R negative regulator of the mglBAC operon for galactose utilization; DNA-binding transcriptional regulator GalS complement(3046889..3047929) Escherichia coli O157:H7 str. EDL933 959368 NP_288735.2 CDS Z3408 NC_002655.2 3048071 3049228 R hypothetical protein complement(3048071..3049228) Escherichia coli O157:H7 str. EDL933 959519 NP_288736.1 CDS folE NC_002655.2 3049245 3049913 R involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I complement(3049245..3049913) Escherichia coli O157:H7 str. EDL933 957115 NP_288737.1 CDS yeiG NC_002655.2 3050171 3051007 D esterase 3050171..3051007 Escherichia coli O157:H7 str. EDL933 959327 NP_288738.1 CDS cirA NC_002655.2 3051039 3053018 R Cir; FeuA; CirA; receptor protein for siderophores (colicin IA, IB and V) and microcins (E492, H47, and M); TonB-dependent; able to transport monomers, dimer, and linear trimers of 2,3-dihydorxybenzoylserine; outer membrane protein; colicin I receptor complement(3051039..3053018) Escherichia coli O157:H7 str. EDL933 956749 NP_288739.1 CDS lysP NC_002655.2 3053310 3054779 R lysine transporter complement(3053310..3054779) Escherichia coli O157:H7 str. EDL933 957056 NP_288740.1 CDS yeiE NC_002655.2 3054984 3055865 R DNA-binding transcriptional regulator complement(3054984..3055865) Escherichia coli O157:H7 str. EDL933 957119 NP_288741.1 CDS yeiH NC_002655.2 3055964 3057013 D hypothetical protein 3055964..3057013 Escherichia coli O157:H7 str. EDL933 957967 NP_288742.1 CDS nfo NC_002655.2 3057087 3057944 D Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues; endonuclease IV 3057087..3057944 Escherichia coli O157:H7 str. EDL933 959540 NP_288743.1 CDS yeiI NC_002655.2 3057947 3059035 D hypothetical protein 3057947..3059035 Escherichia coli O157:H7 str. EDL933 959355 NP_288744.1 CDS yeiJ NC_002655.2 3059091 3060332 R transport system permease complement(3059091..3060332) Escherichia coli O157:H7 str. EDL933 959542 NP_288745.1 CDS rihB NC_002655.2 3060441 3061382 R Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively; ribonucleoside hydrolase 2 complement(3060441..3061382) Escherichia coli O157:H7 str. EDL933 957121 NP_288746.1 CDS yeiL NC_002655.2 3061551 3062210 D activator of nucleoside metabolism; DNA-binding transcriptional activator YeiL 3061551..3062210 Escherichia coli O157:H7 str. EDL933 957264 NP_288747.1 CDS yeiM NC_002655.2 3062281 3063531 R transport system permease complement(3062281..3063531) Escherichia coli O157:H7 str. EDL933 961179 NP_288748.1 CDS yeiN NC_002655.2 3063625 3064563 R hypothetical protein complement(3063625..3064563) Escherichia coli O157:H7 str. EDL933 957764 NP_288749.1 CDS yeiC NC_002655.2 3064551 3065492 R hypothetical protein complement(3064551..3065492) Escherichia coli O157:H7 str. EDL933 959203 NP_288750.1 CDS fruA NC_002655.2 3065916 3067607 R phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system fructose-specific transporter subunit IIBC complement(3065916..3067607) Escherichia coli O157:H7 str. EDL933 957126 NP_288751.1 CDS fruK NC_002655.2 3067624 3068562 R converts fructose-1-phosphate and ATP to fructose-1,6-bisphosphate and ADP; highly specific for fructose-1-phopshate; similar to PfkB; forms homodimers; 1-phosphofructokinase complement(3067624..3068562) Escherichia coli O157:H7 str. EDL933 959326 NP_288752.1 CDS fruB NC_002655.2 3068562 3069692 R phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIA is phosphorylated by phospho-HP which then transfers the phosphoryl group to the IIB componentr; bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein complement(3068562..3069692) Escherichia coli O157:H7 str. EDL933 958260 NP_288753.1 CDS yeiO NC_002655.2 3070060 3071241 D transport 3070060..3071241 Escherichia coli O157:H7 str. EDL933 957127 NP_288754.2 CDS yeiP NC_002655.2 3071647 3072219 D Stimulates the peptidyltransferase activity of the 70S ribosome and enhances dipeptide synthesis with N-formylmethionyl-tRNA and puromycin in vitro, suggesting its involvement in the formation of the first peptide bond of a protein; elongation factor P 3071647..3072219 Escherichia coli O157:H7 str. EDL933 957283 NP_288755.1 CDS yeiQ NC_002655.2 3072442 3073908 D oxidoreductase 3072442..3073908 Escherichia coli O157:H7 str. EDL933 956940 NP_288756.1 CDS yeiR NC_002655.2 3074026 3075012 D hypothetical protein 3074026..3075012 Escherichia coli O157:H7 str. EDL933 959298 NP_288757.1 CDS Z3433 NC_002655.2 3075015 3075764 D hypothetical protein 3075015..3075764 Escherichia coli O157:H7 str. EDL933 957393 NP_288758.1 CDS spr NC_002655.2 3076177 3076743 D by similarity, Spr seems to have peptidase activity; involved in thermoresistance; outer membrane lipoprotein 3076177..3076743 Escherichia coli O157:H7 str. EDL933 957128 NP_288759.1 CDS rtn NC_002655.2 3076925 3078481 D hypothetical protein 3076925..3078481 Escherichia coli O157:H7 str. EDL933 957134 NP_288760.2 CDS yejA NC_002655.2 3078563 3080377 D hypothetical protein 3078563..3080377 Escherichia coli O157:H7 str. EDL933 957136 NP_288761.1 CDS yejB NC_002655.2 3080378 3081472 D transport system permease 3080378..3081472 Escherichia coli O157:H7 str. EDL933 957359 NP_288762.1 CDS yejE NC_002655.2 3081472 3082497 D transport system permease 3081472..3082497 Escherichia coli O157:H7 str. EDL933 957403 NP_288763.1 CDS yejF NC_002655.2 3082499 3084088 D ABC transporter ATP-binding protein 3082499..3084088 Escherichia coli O157:H7 str. EDL933 958086 NP_288764.1 CDS yejG NC_002655.2 3084092 3084436 R hypothetical protein complement(3084092..3084436) Escherichia coli O157:H7 str. EDL933 957142 NP_288765.1 CDS bcr NC_002655.2 3084769 3085959 R Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance; bicyclomycin/multidrug efflux system protein complement(3084769..3085959) Escherichia coli O157:H7 str. EDL933 959264 NP_288766.1 CDS rsuA NC_002655.2 3085987 3086682 R catalyzes the synthesis pseudouridine from uracil-516 in 16S ribosomal RNA; 16S rRNA pseudouridylate synthase A complement(3085987..3086682) Escherichia coli O157:H7 str. EDL933 959609 NP_288767.1 CDS yejH NC_002655.2 3086831 3088591 D ATP-dependent helicase 3086831..3088591 Escherichia coli O157:H7 str. EDL933 961287 NP_288768.1 CDS rplY NC_002655.2 3088716 3089000 D the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25 3088716..3089000 Escherichia coli O157:H7 str. EDL933 957144 NP_288769.1 CDS yejK NC_002655.2 3089139 3090146 R nucleoid-associated protein NdpA complement(3089139..3090146) Escherichia coli O157:H7 str. EDL933 957153 NP_288770.1 CDS yejL NC_002655.2 3090328 3090555 D hypothetical protein 3090328..3090555 Escherichia coli O157:H7 str. EDL933 957154 NP_288771.1 CDS yejM NC_002655.2 3090575 3092335 D sulfatase 3090575..3092335 Escherichia coli O157:H7 str. EDL933 957420 NP_288772.1 CDS yejO NC_002655.2 3092587 3095097 R ABC transporter ATP-binding protein complement(3092587..3095097) Escherichia coli O157:H7 str. EDL933 957156 NP_288773.1 CDS narP NC_002655.2 3095498 3096145 D nitrate/nitrite response regulator NarP; NarP is phosphorylated by NarX and NarQ and can activate fdnG and nitrite or nitrate reductase systems; represses expression of other anaerobic genes; transcriptional regulator NarP 3095498..3096145 Escherichia coli O157:H7 str. EDL933 959502 NP_288774.1 CDS ccmH NC_002655.2 3096180 3097232 R subunit of heme lyase complement(3096180..3097232) Escherichia coli O157:H7 str. EDL933 959377 NP_288775.1 CDS dsbE NC_002655.2 3097229 3097786 R disulfide oxidoreductase complement(3097229..3097786) Escherichia coli O157:H7 str. EDL933 959498 NP_288776.1 CDS ccmF NC_002655.2 3097783 3099726 R cytochrome C biogenesis protein complement(3097783..3099726) Escherichia coli O157:H7 str. EDL933 957050 NP_288777.1 CDS ccmE NC_002655.2 3099723 3100202 R CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane; cytochrome C biogenesis protein CcmE complement(3099723..3100202) Escherichia coli O157:H7 str. EDL933 957167 NP_288778.1 CDS ccmD NC_002655.2 3100199 3100408 R heme exporter protein C complement(3100199..3100408) Escherichia coli O157:H7 str. EDL933 957172 NP_288779.1 CDS ccmC NC_002655.2 3100405 3101142 R heme exporter protein C complement(3100405..3101142) Escherichia coli O157:H7 str. EDL933 957176 NP_288780.1 CDS ccmB NC_002655.2 3101184 3101846 R heme exporter protein B, cytochrome C biogenesis protein complement(3101184..3101846) Escherichia coli O157:H7 str. EDL933 957177 NP_288781.1 CDS ccmA NC_002655.2 3101843 3102460 R ATP-binding protein; required for proper cytochrome c maturation; cytochrome c biogenesis protein CcmA complement(3101843..3102460) Escherichia coli O157:H7 str. EDL933 957178 NP_288782.1 CDS napC NC_002655.2 3102479 3103081 R with NapABDFGH functions as a nitrate reductase; NapC functions as an electron shuttle between NapAB and NapGH or quinone; cytochrome C complement(3102479..3103081) Escherichia coli O157:H7 str. EDL933 960378 NP_288783.2 CDS napB NC_002655.2 3103091 3103540 R small subunit of periplasmic nitrate reductase; receives electrons from the membrane-bound NapC and passes them to NapA; citrate reductase cytochrome C subunit complement(3103091..3103540) Escherichia coli O157:H7 str. EDL933 959552 NP_288784.1 CDS napH NC_002655.2 3103537 3104400 R part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; quinol dehydrogenase membrane component complement(3103537..3104400) Escherichia coli O157:H7 str. EDL933 957268 NP_288785.1 CDS napG NC_002655.2 3104387 3105082 R part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; secreted by twin arginine translocation pathway; quinol dehydrogenase periplasmic component complement(3104387..3105082) Escherichia coli O157:H7 str. EDL933 957182 NP_288786.1 CDS napA NC_002655.2 3105089 3107575 R periplasmic; catalytic subunit; with NapBC catalyzes the reduction of nitrate to nitrite; NapAB receives electrons from NapC; nitrate reductase catalytic subunit complement(3105089..3107575) Escherichia coli O157:H7 str. EDL933 957183 NP_288787.1 CDS napD NC_002655.2 3107572 3107835 R assembly protein for periplasmic nitrate reductase complement(3107572..3107835) Escherichia coli O157:H7 str. EDL933 957465 NP_288788.1 CDS napF NC_002655.2 3107825 3108319 R Predicted role in electron transfer to the periplasmic nitrate reductase NapA.; ferredoxin-type protein complement(3107825..3108319) Escherichia coli O157:H7 str. EDL933 958901 NP_288789.1 CDS eco NC_002655.2 3108726 3109214 D serine protease inhibitor, inhibits trypsin and other proteases; ecotin 3108726..3109214 Escherichia coli O157:H7 str. EDL933 957186 NP_288790.1 CDS yojH NC_002655.2 3109364 3111010 R malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate; malate:quinone oxidoreductase complement(3109364..3111010) Escherichia coli O157:H7 str. EDL933 957188 NP_288791.1 CDS yojI NC_002655.2 3111228 3112871 R efflux pump for the antibacterial peptide microcin J25; multidrug transporter membrane protein/ATP-binding component complement(3111228..3112871) Escherichia coli O157:H7 str. EDL933 961107 NP_288792.1 CDS alkB NC_002655.2 3112947 3113597 R DNA repair system specific for alkylated DNA complement(3112947..3113597) Escherichia coli O157:H7 str. EDL933 961035 NP_288793.1 CDS ada NC_002655.2 3113597 3114661 R O6-methylguanine-DNA methyltransferase; transcription activator/repressor complement(3113597..3114661) Escherichia coli O157:H7 str. EDL933 957191 NP_288794.1 CDS yojL NC_002655.2 3114735 3115790 R catalyzes the conversion of aminoimidazole ribotide to the 4-amino-5-hydroxymethyl-2-methyl pyrimidine moiety of thiamine; involved in the maintenance and/or assembly of sulfur clusters; periplasmic lipoporotein anchored to the inner membrane; part of the thiamine pyrophosphate biosynthesis pathway; thiamine biosynthesis lipoprotein ApbE complement(3114735..3115790) Escherichia coli O157:H7 str. EDL933 957195 NP_288795.1 CDS ompC NC_002655.2 3115902 3117005 R allows for ions and hydrophilic solutes to cross the outer membrane; porin complement(3115902..3117005) Escherichia coli O157:H7 str. EDL933 958280 NP_288796.1 CDS yojN NC_002655.2 3117744 3120416 D phosphotransfer intermediate protein in two-component regulatory system with RcsBC 3117744..3120416 Escherichia coli O157:H7 str. EDL933 961178 NP_288797.1 CDS rcsB NC_002655.2 3120433 3121083 D two-component response regulator RscB regulates the genes involved in capsule biosynthesis and cell division; probably phosphorylated by RcsC or RcsF; transcriptional regulator RcsB 3120433..3121083 Escherichia coli O157:H7 str. EDL933 961169 NP_288798.2 CDS rcsC NC_002655.2 3121283 3124132 R hybrid sensory kinase in two-component regulatory system with RcsB and YojN complement(3121283..3124132) Escherichia coli O157:H7 str. EDL933 957032 NP_288799.1 CDS Z3478 NC_002655.2 3124407 3125183 R hypothetical protein complement(3124407..3125183) Escherichia coli O157:H7 str. EDL933 956682 NP_288800.1 CDS Z3479 NC_002655.2 3125188 3125970 R hypothetical protein complement(3125188..3125970) Escherichia coli O157:H7 str. EDL933 957161 NP_288801.1 CDS Z3480 NC_002655.2 3126043 3126837 R hypothetical protein complement(3126043..3126837) Escherichia coli O157:H7 str. EDL933 957461 NP_288802.1 CDS Z3481 NC_002655.2 3126838 3131442 R hypothetical protein complement(3126838..3131442) Escherichia coli O157:H7 str. EDL933 961302 NP_288803.2 CDS Z3482 NC_002655.2 3131376 3131999 R hypothetical protein complement(3131376..3131999) Escherichia coli O157:H7 str. EDL933 957200 NP_288804.2 CDS yfaA NC_002655.2 3131996 3133594 R hypothetical protein complement(3131996..3133594) Escherichia coli O157:H7 str. EDL933 957203 NP_288805.1 CDS gyrA NC_002655.2 3133832 3136459 R negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit A complement(3133832..3136459) Escherichia coli O157:H7 str. EDL933 957213 NP_288806.1 CDS ubiG NC_002655.2 3136606 3137328 D Involved in ubiquinone biosynthesis; 3-demethylubiquinone-9 3-methyltransferase 3136606..3137328 Escherichia coli O157:H7 str. EDL933 958473 NP_288807.1 CDS yfaL NC_002655.2 3137469 3141221 R adhesin complement(3137469..3141221) Escherichia coli O157:H7 str. EDL933 958126 NP_288808.1 CDS nrdA NC_002655.2 3141917 3144202 D Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 3141917..3144202 Escherichia coli O157:H7 str. EDL933 957217 NP_288809.1 CDS nrdB NC_002655.2 3144429 3145559 D B2 or R2 protein; type 1a enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdA; ribonucleotide-diphosphate reductase subunit beta 3144429..3145559 Escherichia coli O157:H7 str. EDL933 957218 NP_288810.1 CDS yfaE NC_002655.2 3145559 3145813 D plays a role in maintenance and possibly the biosynthesis of diferric-tyrosyl radical cofactor, essential for nucleotide reduction catalyzed by ribonucleotide reductases; 2Fe-2S ferredoxin 3145559..3145813 Escherichia coli O157:H7 str. EDL933 957159 NP_288811.1 CDS inaA NC_002655.2 3145867 3146517 R hypothetical protein complement(3145867..3146517) Escherichia coli O157:H7 str. EDL933 958448 NP_288812.1 CDS Z3494 NC_002655.2 3146598 3147788 R antibiotic efflux protein complement(3146598..3147788) Escherichia coli O157:H7 str. EDL933 957220 NP_288813.1 CDS Z3495 NC_002655.2 3147940 3148818 D regulator 3147940..3148818 Escherichia coli O157:H7 str. EDL933 957276 NP_288814.1 CDS Z3496 NC_002655.2 3149282 3150352 D No significant matches; hypothetical protein 3149282..3150352 Escherichia coli O157:H7 str. EDL933 957222 NP_288815.1 CDS glpQ NC_002655.2 3150576 3151652 R hydrolyzes deacylated phospholipids to glycerol 3-phosphate and the corresponding alcohols; periplasmic; glycerophosphodiester phosphodiesterase complement(3150576..3151652) Escherichia coli O157:H7 str. EDL933 957223 NP_288816.1 CDS glpT NC_002655.2 3151657 3153015 R catalyzes the uptake of glycerol-3-phosphate into the cell with the simultaneous export of inorganic phosphate from the cell; sn-glycerol-3-phosphate transporter complement(3151657..3153015) Escherichia coli O157:H7 str. EDL933 957229 NP_288817.1 CDS glpA NC_002655.2 3153288 3154916 D anaerobic, catalyzes the conversion of glycerol 3-phosphate to dihydroxyacetone using fumarate or nitrate as electron acceptor; sn-glycerol-3-phosphate dehydrogenase subunit A 3153288..3154916 Escherichia coli O157:H7 str. EDL933 959442 NP_288818.1 CDS glpB NC_002655.2 3154906 3156165 D sn-glycerol-3-phosphate dehydrogenase (anaerobic); catalyzes the formation of dihydroxyacetone from glycerol 3-phosphate; part of GlpABC complex; presumably this subunit is responsible for membrane interactions and contains iron-sulfur clusters; anaerobic glycerol-3-phosphate dehydrogenase subunit B 3154906..3156165 Escherichia coli O157:H7 str. EDL933 956952 NP_288819.1 CDS glpC NC_002655.2 3156162 3157352 D anaerobic; with GlpAB catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate; sn-glycerol-3-phosphate dehydrogenase subunit C 3156162..3157352 Escherichia coli O157:H7 str. EDL933 959546 NP_288820.1 CDS yfaD NC_002655.2 3157545 3158471 D hypothetical protein 3157545..3158471 Escherichia coli O157:H7 str. EDL933 958312 NP_288821.1 CDS Z3503 NC_002655.2 3158512 3159264 R aldolase complement(3158512..3159264) Escherichia coli O157:H7 str. EDL933 957237 NP_288822.1 CDS Z3504 NC_002655.2 3159332 3160660 R transporter complement(3159332..3160660) Escherichia coli O157:H7 str. EDL933 957238 NP_288823.1 CDS Z3505 NC_002655.2 3160678 3161895 R racemase complement(3160678..3161895) Escherichia coli O157:H7 str. EDL933 959528 NP_288824.1 CDS Z3506 NC_002655.2 3161898 3162680 R regulator complement(3161898..3162680) Escherichia coli O157:H7 str. EDL933 959533 NP_288825.1 CDS Z3507 NC_002655.2 3162900 3164102 R competence damage-inducible protein A complement(3162900..3164102) Escherichia coli O157:H7 str. EDL933 960973 NP_288826.1 CDS Z3508 NC_002655.2 3164202 3164765 R hypothetical protein complement(3164202..3164765) Escherichia coli O157:H7 str. EDL933 957240 NP_288827.1 CDS yfaO NC_002655.2 3165023 3165448 D hypothetical protein 3165023..3165448 Escherichia coli O157:H7 str. EDL933 957241 NP_288828.1 CDS ais NC_002655.2 3165487 3166089 R protein induced by aluminum complement(3165487..3166089) Escherichia coli O157:H7 str. EDL933 958508 NP_288829.2 CDS Z3511 NC_002655.2 3166397 3167536 D catalyzes the conversion of UDP-4-keto-arabinose to UDP-4-amino-4-deoxy-L-arabinose; UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase 3166397..3167536 Escherichia coli O157:H7 str. EDL933 956897 NP_288830.1 CDS Z3512 NC_002655.2 3167540 3168508 D catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate; undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase 3167540..3168508 Escherichia coli O157:H7 str. EDL933 957251 NP_288831.1 CDS Z3513 NC_002655.2 3168508 3170490 D Bifunctional polymyxin resistance arnA protein; catalyzes the decarboxylation of UDP-glucuronic acid to UDP-4-keto-arabinose and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose to form UDP-L-4-formamido-arabinose; active in certain mutant strains; bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase 3168508..3170490 Escherichia coli O157:H7 str. EDL933 957675 NP_288832.1 CDS Z3514 NC_002655.2 3170487 3171377 D hypothetical protein 3170487..3171377 Escherichia coli O157:H7 str. EDL933 959273 NP_288833.1 CDS arnT NC_002655.2 3171377 3173029 D catalyzes the addition of 4-amino-4-deoxy-L-arabinose to lipid A; 4-amino-4-deoxy-L-arabinose transferase 3171377..3173029 Escherichia coli O157:H7 str. EDL933 957170 NP_288834.1 CDS Z3516 NC_002655.2 3173026 3173361 D No significant matches; hypothetical protein 3173026..3173361 Escherichia coli O157:H7 str. EDL933 959301 NP_288835.2 CDS Z3517 NC_002655.2 3173361 3173747 D hypothetical protein 3173361..3173747 Escherichia coli O157:H7 str. EDL933 957272 NP_288836.1 CDS pmrD NC_002655.2 3173741 3174037 R polymyxin resistance protein B complement(3173741..3174037) Escherichia coli O157:H7 str. EDL933 959289 NP_288838.1 CDS menE NC_002655.2 3174117 3175472 R O-succinylbenzoic acid--CoA ligase complement(3174117..3175472) Escherichia coli O157:H7 str. EDL933 959419 NP_288839.1 CDS menC NC_002655.2 3175469 3176431 R catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate; O-succinylbenzoate synthase complement(3175469..3176431) Escherichia coli O157:H7 str. EDL933 957275 NP_288840.1 CDS menB NC_002655.2 3176431 3177288 R catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA; naphthoate synthase complement(3176431..3177288) Escherichia coli O157:H7 str. EDL933 959317 NP_288841.1 CDS yfbB NC_002655.2 3177303 3178061 R catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; acyl-CoA thioester hydrolase complement(3177303..3178061) Escherichia coli O157:H7 str. EDL933 957858 NP_288842.1 CDS menD NC_002655.2 3178058 3179728 R SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis; 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase complement(3178058..3179728) Escherichia coli O157:H7 str. EDL933 957277 NP_288843.3 CDS menF NC_002655.2 3179817 3181112 R synthesizes isochorismate acid from chorismate; menaquinone-specific isochorismate synthase complement(3179817..3181112) Escherichia coli O157:H7 str. EDL933 957285 NP_288844.1 CDS elaB NC_002655.2 3181191 3181496 R hypothetical protein complement(3181191..3181496) Escherichia coli O157:H7 str. EDL933 961187 NP_288845.1 CDS elaA NC_002655.2 3181551 3182012 R hypothetical protein complement(3181551..3182012) Escherichia coli O157:H7 str. EDL933 958335 NP_288846.2 CDS elaC NC_002655.2 3182077 3182994 D member of metallo-beta-lactamase; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions; ribonuclease Z 3182077..3182994 Escherichia coli O157:H7 str. EDL933 957820 NP_288847.1 CDS elaD NC_002655.2 3183182 3184405 D ElaD; specific cysteine protease which targets ubiquitin and ubiquitin-like proteins covalently bound to target proteins; SseL in Salmonella is required for macrophage killing and virulence, and it is secreted by the salmonella pathogenicity island 2 type III secretion system; deubiquitinase 3183182..3184405 Escherichia coli O157:H7 str. EDL933 957300 NP_288848.1 CDS Z3531 NC_002655.2 3185192 3185434 D hypothetical protein 3185192..3185434 Escherichia coli O157:H7 str. EDL933 957310 NP_288849.1 CDS yfbM NC_002655.2 3185537 3186040 D hypothetical protein 3185537..3186040 Escherichia coli O157:H7 str. EDL933 957316 NP_288850.2 CDS nuoN NC_002655.2 3186107 3187564 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit N complement(3186107..3187564) Escherichia coli O157:H7 str. EDL933 957323 NP_288851.1 CDS nuoM NC_002655.2 3187571 3189100 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit M complement(3187571..3189100) Escherichia coli O157:H7 str. EDL933 957330 NP_288852.1 CDS nuoL NC_002655.2 3189331 3191172 R Catalyzes the transfer of electrons from NADH to ubiquinone; NADH dehydrogenase subunit L complement(3189331..3191172) Escherichia coli O157:H7 str. EDL933 959531 NP_288853.1 CDS nuoK NC_002655.2 3191169 3191471 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit K complement(3191169..3191471) Escherichia coli O157:H7 str. EDL933 957520 NP_288854.1 CDS nuoJ NC_002655.2 3191468 3192022 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit J complement(3191468..3192022) Escherichia coli O157:H7 str. EDL933 961418 NP_288855.1 CDS nuoI NC_002655.2 3192034 3192576 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit I complement(3192034..3192576) Escherichia coli O157:H7 str. EDL933 957341 NP_288856.1 CDS nuoH NC_002655.2 3192591 3193568 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit H complement(3192591..3193568) Escherichia coli O157:H7 str. EDL933 956906 NP_288857.1 CDS nuoG NC_002655.2 3193565 3196297 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit G complement(3193565..3196297) Escherichia coli O157:H7 str. EDL933 957432 NP_288858.1 CDS nuoF NC_002655.2 3196344 3197681 R shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; NuoF is part of the soluble NADH dehydrogenase fragment, which represents the electron input part of NADH dehydrogenase; NADH dehydrogenase I subunit F complement(3196344..3197681) Escherichia coli O157:H7 str. EDL933 959260 NP_288859.1 CDS nuoE NC_002655.2 3197678 3198178 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit E complement(3197678..3198178) Escherichia coli O157:H7 str. EDL933 957351 NP_288860.1 CDS nuoC NC_002655.2 3198181 3199983 R NuoCD; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; subunits NuoCD, E, F, and G constitute the peripheral sector of the complex; in Escherichia coli this gene encodes a fusion protein of NuoC and NuoD that are found separate in other organisms; bifunctional NADH:ubiquinone oxidoreductase subunit C/D complement(3198181..3199983) Escherichia coli O157:H7 str. EDL933 958352 NP_288861.1 CDS nuoB NC_002655.2 3200077 3200739 R The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen; NADH dehydrogenase subunit B complement(3200077..3200739) Escherichia coli O157:H7 str. EDL933 958339 NP_288862.1 CDS nuoA NC_002655.2 3200755 3201198 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit A complement(3200755..3201198) Escherichia coli O157:H7 str. EDL933 957052 NP_288863.1 CDS lrhA NC_002655.2 3201829 3202767 R LysR family transcriptional regulator complement(3201829..3202767) Escherichia coli O157:H7 str. EDL933 957618 NP_288864.1 CDS Z3551 NC_002655.2 3203687 3204904 D broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase 3203687..3204904 Escherichia coli O157:H7 str. EDL933 957354 NP_288865.1 CDS Z3552 NC_002655.2 3204988 3205587 D hypothetical protein 3204988..3205587 Escherichia coli O157:H7 str. EDL933 957793 NP_288866.1 CDS yfbS NC_002655.2 3205646 3207478 R transporter complement(3205646..3207478) Escherichia coli O157:H7 str. EDL933 958204 NP_288867.1 CDS yfbT NC_002655.2 3207565 3208215 R phosphatase complement(3207565..3208215) Escherichia coli O157:H7 str. EDL933 956786 NP_288868.2 CDS Z3555 NC_002655.2 3208226 3208720 R hypothetical protein complement(3208226..3208720) Escherichia coli O157:H7 str. EDL933 957358 NP_288869.1 CDS Z3556 NC_002655.2 3208803 3209258 R hypothetical protein complement(3208803..3209258) Escherichia coli O157:H7 str. EDL933 957374 NP_288870.1 CDS ackA NC_002655.2 3209596 3210798 D AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase 3209596..3210798 Escherichia coli O157:H7 str. EDL933 958184 NP_288871.1 CDS pta NC_002655.2 3210873 3213017 D catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate; phosphate acetyltransferase 3210873..3213017 Escherichia coli O157:H7 str. EDL933 959575 NP_288872.2 CDS yfcC NC_002655.2 3213207 3214727 D hypothetical protein 3213207..3214727 Escherichia coli O157:H7 str. EDL933 957381 NP_288873.1 CDS Z3561 NC_002655.2 3214760 3215302 R regulator complement(3214760..3215302) Escherichia coli O157:H7 str. EDL933 957158 NP_288874.1 CDS yfcE NC_002655.2 3215360 3215914 R phosphodiesterase complement(3215360..3215914) Escherichia coli O157:H7 str. EDL933 958187 NP_288875.1 CDS yfcF NC_002655.2 3215967 3216611 R hypothetical protein complement(3215967..3216611) Escherichia coli O157:H7 str. EDL933 957386 NP_288876.1 CDS yfcG NC_002655.2 3216747 3217394 D glutathione S-transferase 3216747..3217394 Escherichia coli O157:H7 str. EDL933 959295 NP_288877.1 CDS folX NC_002655.2 3217451 3217813 D catalyzes the formation of dihydromonapterin triphosphate from dihydroneopterin triphosphate; D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase 3217451..3217813 Escherichia coli O157:H7 str. EDL933 958188 NP_288878.1 CDS Z3566 NC_002655.2 3217834 3218727 D sugar nucleotide epimerase 3217834..3218727 Escherichia coli O157:H7 str. EDL933 957388 NP_288879.1 CDS yfcI NC_002655.2 3218775 3219665 R hypothetical protein complement(3218775..3219665) Escherichia coli O157:H7 str. EDL933 959027 NP_288880.1 CDS hisP NC_002655.2 3219862 3220635 R histidine/lysine/arginine/ornithine transporter subunit complement(3219862..3220635) Escherichia coli O157:H7 str. EDL933 961714 NP_288881.1 CDS hisM NC_002655.2 3220643 3221359 R histidine transport, membrane protein M complement(3220643..3221359) Escherichia coli O157:H7 str. EDL933 957390 NP_288882.1 CDS hisQ NC_002655.2 3221356 3222042 R histidine transport system permease complement(3221356..3222042) Escherichia coli O157:H7 str. EDL933 957391 NP_288883.1 CDS hisJ NC_002655.2 3222132 3222914 R histidine-binding periplasmic protein of high-affinity histidine transport system complement(3222132..3222914) Escherichia coli O157:H7 str. EDL933 959529 NP_288884.1 CDS argT NC_002655.2 3223135 3223917 R lysine-, arginine-, ornithine-binding periplasmic protein complement(3223135..3223917) Escherichia coli O157:H7 str. EDL933 959530 NP_288885.1 CDS ubiX NC_002655.2 3224183 3224752 R catalyzes the formation of 2-octaprenylphenol from 3-octaprenyl-4-hydroxybenzoate; 3-octaprenyl-4-hydroxybenzoate carboxy-lyase complement(3224183..3224752) Escherichia coli O157:H7 str. EDL933 959527 NP_288886.1 CDS purF NC_002655.2 3224847 3226364 R Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase complement(3224847..3226364) Escherichia coli O157:H7 str. EDL933 959520 NP_288887.1 CDS cvpA NC_002655.2 3226401 3226889 R membrane protein required for colicin V production; colicin V production protein complement(3226401..3226889) Escherichia coli O157:H7 str. EDL933 957414 NP_288888.1 CDS dedD NC_002655.2 3227331 3227993 R hypothetical protein complement(3227331..3227993) Escherichia coli O157:H7 str. EDL933 959039 NP_288889.1 CDS folC NC_002655.2 3227983 3229251 R bifunctional folylpolyglutamate synthase/ dihydrofolate synthase complement(3227983..3229251) Escherichia coli O157:H7 str. EDL933 957529 NP_288890.1 CDS accD NC_002655.2 3229321 3230235 R catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits; acetyl-CoA carboxylase subunit beta complement(3229321..3230235) Escherichia coli O157:H7 str. EDL933 957472 NP_288891.1 CDS dedA NC_002655.2 3230391 3231050 R hypothetical protein complement(3230391..3231050) Escherichia coli O157:H7 str. EDL933 957482 NP_288892.1 CDS truA NC_002655.2 3231133 3231945 R mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A complement(3231133..3231945) Escherichia coli O157:H7 str. EDL933 957710 NP_288893.1 CDS usg NC_002655.2 3231945 3232958 R semialdehyde dehydrogenase complement(3231945..3232958) Escherichia coli O157:H7 str. EDL933 957527 NP_288894.1 CDS pdxB NC_002655.2 3233024 3234160 R catalyzes the formation of 3-hydroxy-4-phospho-hydroxy-alpha-ketobutyrate from erythronate-4-phosphate; erythronate-4-phosphate dehydrogenase complement(3233024..3234160) Escherichia coli O157:H7 str. EDL933 957490 NP_288895.1 CDS flk NC_002655.2 3234259 3235254 D in Salmonella typhimurium Flk regulates flagellar biosynthesis by inhibition of the flagellar-associated type III secretion system; lowers secretion levels of the anti-sigma28 factor FlgM to the periplasm; inner membrane-anchored protein; flagella biosynthesis regulator 3234259..3235254 Escherichia coli O157:H7 str. EDL933 957499 NP_288896.1 CDS Z3585 NC_002655.2 3235251 3236429 R hypothetical protein complement(3235251..3236429) Escherichia coli O157:H7 str. EDL933 958147 NP_288897.1 CDS fabB NC_002655.2 3236704 3237924 R FabB, beta-Ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase complement(3236704..3237924) Escherichia coli O157:H7 str. EDL933 957480 NP_288898.2 CDS mnmC NC_002655.2 3238083 3240089 D catalyzes the formation of 5-methylaminomethyl-2-thiouridine in position 34 of the anticodon of tRNA molecules; 5-methylaminomethyl-2-thiouridine methyltransferase 3238083..3240089 Escherichia coli O157:H7 str. EDL933 957500 NP_288899.1 CDS Z3588 NC_002655.2 3240210 3240488 R hypothetical protein complement(3240210..3240488) Escherichia coli O157:H7 str. EDL933 957504 NP_288900.1 CDS Z3589 NC_002655.2 3240522 3241070 R transporting ATPase complement(3240522..3241070) Escherichia coli O157:H7 str. EDL933 957505 NP_288901.1 CDS yfcA NC_002655.2 3241070 3241879 R hypothetical protein complement(3241070..3241879) Escherichia coli O157:H7 str. EDL933 957506 NP_288902.1 CDS mepA NC_002655.2 3241879 3242703 R D-alanyl-D-alanine endopeptidase; functions in hydrolyzing cell wall peptidoglycan; similar to LAS metallopeptidases; forms a dimer in periplasm; penicillin-insensitive murein endopeptidase complement(3241879..3242703) Escherichia coli O157:H7 str. EDL933 961271 NP_288903.1 CDS aroC NC_002655.2 3242707 3243792 R catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase complement(3242707..3243792) Escherichia coli O157:H7 str. EDL933 961327 NP_288904.1 CDS yfcB NC_002655.2 3243827 3245092 R involved in methylation of ribosomal protein L3; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase complement(3243827..3245092) Escherichia coli O157:H7 str. EDL933 961293 NP_288905.1 CDS Z3594 NC_002655.2 3244925 3245476 D hypothetical protein 3244925..3245476 Escherichia coli O157:H7 str. EDL933 957513 NP_288906.1 CDS Z3595 NC_002655.2 3245647 3246489 R hypothetical protein complement(3245647..3246489) Escherichia coli O157:H7 str. EDL933 957583 NP_288907.1 CDS Z3596 NC_002655.2 3246491 3247012 R minor fimbrial subunit complement(3246491..3247012) Escherichia coli O157:H7 str. EDL933 957046 NP_288908.1 CDS Z3597 NC_002655.2 3247009 3247479 R minor fimbrial subunit complement(3247009..3247479) Escherichia coli O157:H7 str. EDL933 960278 NP_288909.1 CDS Z3598 NC_002655.2 3247476 3248069 R minor fimbrial subunit complement(3247476..3248069) Escherichia coli O157:H7 str. EDL933 957516 NP_288910.1 CDS yfcS NC_002655.2 3247987 3248745 R fimbrial chaperone complement(3247987..3248745) Escherichia coli O157:H7 str. EDL933 957517 NP_288911.2 CDS Z3600 NC_002655.2 3248768 3251407 R fimbrial usher complement(3248768..3251407) Escherichia coli O157:H7 str. EDL933 957523 NP_288912.1 CDS Z3601 NC_002655.2 3251489 3252052 R major fimbrial subunit complement(3251489..3252052) Escherichia coli O157:H7 str. EDL933 957669 NP_288913.1 CDS Z3603 NC_002655.2 3252698 3253183 R phosphohistidine phosphatase complement(3252698..3253183) Escherichia coli O157:H7 str. EDL933 958720 NP_288914.1 CDS fadJ NC_002655.2 3253386 3255530 R multifunctional enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase/3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities: forms a heterotetramer with FadI; similar to FadA2B2 complex; involved in the anaerobic degradation of long and medium-chain fatty acids in the presence of nitrate; multifunctional fatty acid oxidation complex subunit alpha complement(3253386..3255530) Escherichia coli O157:H7 str. EDL933 959521 NP_288915.1 CDS fadI NC_002655.2 3255530 3256840 R FadI; fatty acid oxidation complex component beta; functions in a heterotetramer with FadJ; similar to FadA2B2 complex; functions in beta-oxidation of fatty acids during anaerobic growth; 3-ketoacyl-CoA thiolase complement(3255530..3256840) Escherichia coli O157:H7 str. EDL933 957526 NP_288916.1 CDS Z3606 NC_002655.2 3257020 3257328 R hypothetical protein complement(3257020..3257328) Escherichia coli O157:H7 str. EDL933 958565 NP_288917.1 CDS fadL NC_002655.2 3257670 3259016 D long-chain fatty acid outer membrane transporter 3257670..3259016 Escherichia coli O157:H7 str. EDL933 961192 NP_288918.1 CDS Z3609 NC_002655.2 3259381 3260412 D hypothetical protein 3259381..3260412 Escherichia coli O157:H7 str. EDL933 958349 NP_288919.1 CDS vacJ NC_002655.2 3260807 3261562 R lipoprotein precursor complement(3260807..3261562) Escherichia coli O157:H7 str. EDL933 957528 NP_288920.1 CDS yfdC NC_002655.2 3261856 3262788 D transport 3261856..3262788 Escherichia coli O157:H7 str. EDL933 957531 NP_288921.1 CDS intC NC_002655.2 3263064 3264257 D prophage integrase 3263064..3264257 Escherichia coli O157:H7 str. EDL933 960221 NP_288922.1 CDS Z3614 NC_002655.2 3264432 3265568 R prophage DNA injection protein complement(3264432..3265568) Escherichia coli O157:H7 str. EDL933 957541 NP_288923.1 CDS Z3615 NC_002655.2 3265578 3266258 R prophage DNA injection protein complement(3265578..3266258) Escherichia coli O157:H7 str. EDL933 960714 NP_288924.1 CDS Z3616 NC_002655.2 3266245 3266712 R hypothetical protein complement(3266245..3266712) Escherichia coli O157:H7 str. EDL933 960715 NP_288925.1 CDS Z3617 NC_002655.2 3266712 3267281 R No significant matches; hypothetical protein complement(3266712..3267281) Escherichia coli O157:H7 str. EDL933 961333 NP_288926.1 CDS Z3618 NC_002655.2 3267264 3267959 D No significant matches; hypothetical protein 3267264..3267959 Escherichia coli O157:H7 str. EDL933 957542 NP_288927.1 CDS Z3619 NC_002655.2 3268139 3268282 R No significant matches; hypothetical protein complement(3268139..3268282) Escherichia coli O157:H7 str. EDL933 957545 NP_288928.1 CDS Z3620 NC_002655.2 3268629 3270041 R No significant matches; hypothetical protein complement(3268629..3270041) Escherichia coli O157:H7 str. EDL933 961230 NP_288929.1 CDS Z3621 NC_002655.2 3270228 3270404 R No significant matches; hypothetical protein complement(3270228..3270404) Escherichia coli O157:H7 str. EDL933 959294 NP_288930.1 CDS Z3622 NC_002655.2 3270707 3271333 D resolvase 3270707..3271333 Escherichia coli O157:H7 str. EDL933 957549 NP_288931.1 CDS lacY NC_002655.2 3271931 3273178 R lactose/proton symporter; mediates lactose/proton symport through the membrane by utilizing the proton gradient to drive transport of galactosides; member of major facilitator superfamily; functions as a monomer with 12 transmembrane segments; galactoside permease complement(3271931..3273178) Escherichia coli O157:H7 str. EDL933 958132 NP_288932.1 CDS Z3624 NC_002655.2 3273250 3274167 R phosphorylates aminoimidazole ribotide (AIR) which forms 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate (HMP-P); synthesis of HMP-P from AIR is complex and requires the product of thiC gene at least; aminoimidazole riboside kinase complement(3273250..3274167) Escherichia coli O157:H7 str. EDL933 956713 NP_288933.1 CDS Z3625 NC_002655.2 3274383 3275816 D sucrose hydrolase 3274383..3275816 Escherichia coli O157:H7 str. EDL933 957503 NP_288934.1 CDS Z3626 NC_002655.2 3275824 3276819 R sucrose specific transcriptional regulator complement(3275824..3276819) Escherichia coli O157:H7 str. EDL933 957550 NP_288935.1 CDS Z3627 NC_002655.2 3277062 3277280 D D-serine permease 3277062..3277280 Escherichia coli O157:H7 str. EDL933 957553 NP_288936.1 CDS dsdA NC_002655.2 3277298 3278626 D catalyzes the formation of pyruvate from serine; D-serine dehydratase 3277298..3278626 Escherichia coli O157:H7 str. EDL933 957546 NP_288937.1 CDS emrY NC_002655.2 3278734 3280272 R multidrug resistance protein Y complement(3278734..3280272) Escherichia coli O157:H7 str. EDL933 957510 NP_288938.1 CDS emrK NC_002655.2 3280272 3281435 R multidrug resistance protein K complement(3280272..3281435) Escherichia coli O157:H7 str. EDL933 959344 NP_288939.1 CDS evgA NC_002655.2 3281851 3282465 D response regulator in two-component regulatory system with EvgS; phosphorylated EvgA activates ompC, emrKY, gadABC, hdeAB and others genes; involved in acid resistance, osmotic adaption, and drug resistance; DNA-binding transcriptional activator EvgA 3281851..3282465 Escherichia coli O157:H7 str. EDL933 958096 NP_288940.1 CDS evgS NC_002655.2 3282470 3286063 D hybrid sensory histidine kinase in two-component regulatory system with EvgA 3282470..3286063 Escherichia coli O157:H7 str. EDL933 957555 NP_288941.1 CDS yfdE NC_002655.2 3286119 3287299 R hypothetical protein complement(join(3286119..3287087,3287084..3287299)) Escherichia coli O157:H7 str. EDL933 959628 NP_288942.1 CDS Z3635 NC_002655.2 3287334 3288278 R member of the AEC family of auxin efflux transporters; unknown function; transporter YfdV complement(3287334..3288278) Escherichia coli O157:H7 str. EDL933 958378 NP_288943.1 CDS Z3637 NC_002655.2 3288348 3290042 R catalyzes the formation of formyl-CoA from oxalyl-CoA; oxalyl-CoA decarboxylase complement(3288348..3290042) Escherichia coli O157:H7 str. EDL933 956741 NP_288944.1 CDS Z3639 NC_002655.2 3290096 3291346 R catalyzes the formation of oxalyl-CoA from oxalate and Formyl-CoA; formyl-coenzyme A transferase complement(3290096..3291346) Escherichia coli O157:H7 str. EDL933 957557 NP_288945.1 CDS Z3640 NC_002655.2 3291859 3292494 R hypothetical protein complement(3291859..3292494) Escherichia coli O157:H7 str. EDL933 957561 NP_288946.1 CDS Z3641 NC_002655.2 3292790 3293065 D hypothetical protein 3292790..3293065 Escherichia coli O157:H7 str. EDL933 959420 NP_288947.1 CDS Z3642 NC_002655.2 3293142 3293384 R hypothetical protein complement(3293142..3293384) Escherichia coli O157:H7 str. EDL933 957568 NP_288948.2 CDS ddg NC_002655.2 3293738 3294658 D Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(palmitoleoyl)-lipid IVA in cells subjected to cold shock; lipid A biosynthesis palmitoleoyl acyltransferase 3293738..3294658 Escherichia coli O157:H7 str. EDL933 957573 NP_288949.1 CDS Z3644 NC_002655.2 3295150 3296388 R aminotransferase complement(3295150..3296388) Escherichia coli O157:H7 str. EDL933 957576 NP_288950.1 CDS Z3645 NC_002655.2 3296765 3298462 D sensor protein 3296765..3298462 Escherichia coli O157:H7 str. EDL933 957579 NP_288951.1 CDS Z3646 NC_002655.2 3298477 3299211 D 2-component transcriptional regulator 3298477..3299211 Escherichia coli O157:H7 str. EDL933 957585 NP_288952.1 CDS Z3647 NC_002655.2 3299224 3300081 D AraC family transcriptional regulator 3299224..3300081 Escherichia coli O157:H7 str. EDL933 957584 NP_288953.1 CDS Z3648 NC_002655.2 3300084 3302579 R PTS system enzyme IIA component, enzyme I complement(3300084..3302579) Escherichia coli O157:H7 str. EDL933 957582 NP_288954.1 CDS Z3649 NC_002655.2 3302604 3303641 R metalloprotein; exoaminopeptidase complement(3302604..3303641) Escherichia coli O157:H7 str. EDL933 957593 NP_288955.1 CDS Z3651 NC_002655.2 3303641 3304726 R Xaa-Pro aminopeptidase; limited methionine aminopeptidase; aminopeptidase complement(3303641..3304726) Escherichia coli O157:H7 str. EDL933 957594 NP_288956.1 CDS Z3652 NC_002655.2 3304741 3305988 R transporter complement(3304741..3305988) Escherichia coli O157:H7 str. EDL933 957598 NP_288957.1 CDS Z3653 NC_002655.2 3306010 3306336 R PTS system enzyme IIB component complement(3306010..3306336) Escherichia coli O157:H7 str. EDL933 959383 NP_288958.1 CDS glk NC_002655.2 3306555 3307520 R catalyzes the conversion of ATP and D-glucose to ADP and D-glucose 6-phosphate; glucokinase complement(3306555..3307520) Escherichia coli O157:H7 str. EDL933 961924 NP_288959.1 CDS Z3655 NC_002655.2 3307724 3308980 D hypothetical protein 3307724..3308980 Escherichia coli O157:H7 str. EDL933 959138 NP_288960.1 CDS Z3656 NC_002655.2 3309095 3309421 D hypothetical protein 3309095..3309421 Escherichia coli O157:H7 str. EDL933 957602 NP_288962.1 CDS Z3658 NC_002655.2 3309561 3310799 R manganese transport protein MntH complement(3309561..3310799) Escherichia coli O157:H7 str. EDL933 960734 NP_288963.1 CDS nupC NC_002655.2 3311135 3312337 D permease of transport system for 3 nucleosides 3311135..3312337 Escherichia coli O157:H7 str. EDL933 960712 NP_288964.1 CDS yfeA NC_002655.2 3312387 3314615 R hypothetical protein complement(3312387..3314615) Escherichia coli O157:H7 str. EDL933 960721 NP_288965.1 CDS yfeC NC_002655.2 3315080 3315439 D hypothetical protein 3315080..3315439 Escherichia coli O157:H7 str. EDL933 957610 NP_288966.1 CDS yfeD NC_002655.2 3315441 3315833 D hypothetical protein 3315441..3315833 Escherichia coli O157:H7 str. EDL933 956903 NP_288967.1 CDS Z3664 NC_002655.2 3315873 3317081 R virulence protein complement(3315873..3317081) Escherichia coli O157:H7 str. EDL933 959536 NP_288968.1 CDS gltX NC_002655.2 3317632 3319047 R Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase complement(3317632..3319047) Escherichia coli O157:H7 str. EDL933 957612 NP_288969.1 CDS Z3672 NC_002655.2 3319823 3320164 D hypothetical protein 3319823..3320164 Escherichia coli O157:H7 str. EDL933 958232 NP_288970.1 CDS yfeR NC_002655.2 3320155 3321081 R transcriptional regulator complement(3320155..3321081) Escherichia coli O157:H7 str. EDL933 959627 NP_288971.1 CDS yfeH NC_002655.2 3321171 3322169 D cytochrome oxidase 3321171..3322169 Escherichia coli O157:H7 str. EDL933 958427 NP_288972.1 CDS Z3676 NC_002655.2 3322166 3322384 R No significant matches; hypothetical protein complement(3322166..3322384) Escherichia coli O157:H7 str. EDL933 957623 NP_288973.1 CDS ligA NC_002655.2 3322386 3324401 R this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA complement(3322386..3324401) Escherichia coli O157:H7 str. EDL933 957625 NP_288974.1 CDS zipA NC_002655.2 3324472 3325458 R interacts with cell division protein FitsZ and may be required to anchor septal ring structure; cell division protein ZipA complement(3324472..3325458) Escherichia coli O157:H7 str. EDL933 957627 NP_288975.1 CDS cysZ NC_002655.2 3325688 3326449 D role in sulfur assimilation; sulfate transport protein CysZ 3325688..3326449 Escherichia coli O157:H7 str. EDL933 957629 NP_288976.1 CDS cysK NC_002655.2 3326634 3327605 D CysK; forms a complex with serine acetyltransferase CysE; functions in cysteine biosynthesis; cysteine synthase A 3326634..3327605 Escherichia coli O157:H7 str. EDL933 957634 NP_288977.1 CDS ptsH NC_002655.2 3327989 3328246 D PTS system phosphohistidinoprotein-hexose phosphotransferase Hpr 3327989..3328246 Escherichia coli O157:H7 str. EDL933 957637 NP_288978.1 CDS ptsI NC_002655.2 3328291 3330018 D Phosphotransferase system, enzyme I; transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein; part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active-transport system; phosphoenolpyruvate-protein phosphotransferase 3328291..3330018 Escherichia coli O157:H7 str. EDL933 957641 NP_288979.1 CDS crr NC_002655.2 3330059 3330568 D functions in phosphoenolpyruvate-(PEP)-dependent phosphotransferase (PTS) system; functions in the transport and phosphorylation of glucose; PTS system glucose-specific transporter 3330059..3330568 Escherichia coli O157:H7 str. EDL933 957642 NP_288980.2 CDS pdxK NC_002655.2 3330611 3331462 R catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal; pyridoxal kinase complement(3330611..3331462) Escherichia coli O157:H7 str. EDL933 957643 NP_288981.1 CDS yfeK NC_002655.2 3331567 3331899 D hypothetical protein 3331567..3331899 Escherichia coli O157:H7 str. EDL933 958482 NP_288982.1 CDS cysM NC_002655.2 3331937 3332848 R catalyzes the formation of cysteine from 3-O-acetyl-L-serine and hydrogen sulfide; cysteine synthase B complement(3331937..3332848) Escherichia coli O157:H7 str. EDL933 958490 NP_288983.1 CDS cysA NC_002655.2 3332982 3334079 R sulfate/thiosulfate transporter subunit complement(3332982..3334079) Escherichia coli O157:H7 str. EDL933 958489 NP_288984.1 CDS cysW NC_002655.2 3334069 3334944 R Part of the ABC transporter complex cysAWTP involved in sulfate/thiosulfate import; sulfate/thiosulfate transporter permease subunit complement(3334069..3334944) Escherichia coli O157:H7 str. EDL933 959635 NP_288985.1 CDS cysU NC_002655.2 3334944 3335777 R sulfate/thiosulfate transporter subunit complement(3334944..3335777) Escherichia coli O157:H7 str. EDL933 959620 NP_288986.1 CDS cysP NC_002655.2 3335777 3336793 R thiosulfate transporter subunit complement(3335777..3336793) Escherichia coli O157:H7 str. EDL933 957646 NP_288987.2 CDS ucpA NC_002655.2 3336951 3337742 R short chain dehydrogenase complement(3336951..3337742) Escherichia coli O157:H7 str. EDL933 957651 NP_288988.1 CDS yfeT NC_002655.2 3337871 3338728 R hypothetical protein complement(3337871..3338728) Escherichia coli O157:H7 str. EDL933 957653 NP_288989.1 CDS murQ NC_002655.2 3338892 3339788 D catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway; N-acetylmuramic acid 6-phosphate etherase 3338892..3339788 Escherichia coli O157:H7 str. EDL933 957656 NP_288990.1 CDS murP NC_002655.2 3339792 3341216 D belongs to PEP-dependent PTS system; contains the PTS EIIBC domains; involved in uptake of exogenous N-acetylmuramic acid (MurNAc); requires crr-encoded enzyme IIA-glucose component; PTS system N-acetylmuramic acid transporter subunit IIBC 3339792..3341216 Escherichia coli O157:H7 str. EDL933 957975 NP_288991.2 CDS Z3695 NC_002655.2 3341221 3342525 D hypothetical protein 3341221..3342525 Escherichia coli O157:H7 str. EDL933 958111 NP_288992.1 CDS Z3696 NC_002655.2 3342583 3343509 R hypothetical protein complement(3342583..3343509) Escherichia coli O157:H7 str. EDL933 959394 NP_288993.1 CDS Z3697 NC_002655.2 3343578 3344153 R hypothetical protein complement(3343578..3344153) Escherichia coli O157:H7 str. EDL933 957657 NP_288994.1 CDS Z3698 NC_002655.2 3344214 3344669 R hypothetical protein complement(3344214..3344669) Escherichia coli O157:H7 str. EDL933 957663 NP_288995.2 CDS Z3699 NC_002655.2 3344650 3345075 R acetyltransferase complement(3344650..3345075) Escherichia coli O157:H7 str. EDL933 957664 NP_288996.1 CDS amiA NC_002655.2 3345289 3346158 D N-acetylmuramoyl-L-alanine amidase 3345289..3346158 Escherichia coli O157:H7 str. EDL933 957665 NP_288997.1 CDS hemF NC_002655.2 3346162 3347061 D catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis; coproporphyrinogen III oxidase 3346162..3347061 Escherichia coli O157:H7 str. EDL933 957667 NP_288998.1 CDS yfeG NC_002655.2 3347067 3348119 R activates the transcription of the ethanolamine utilization operon; transcriptional regulator EutR complement(3347067..3348119) Escherichia coli O157:H7 str. EDL933 957125 NP_288999.1 CDS Z3703 NC_002655.2 3348165 3348671 R hypothetical protein complement(3348165..3348671) Escherichia coli O157:H7 str. EDL933 960434 NP_289000.1 CDS Z3704 NC_002655.2 3348678 3349337 R hypothetical protein complement(3348678..3349337) Escherichia coli O157:H7 str. EDL933 957668 NP_289001.1 CDS eutC NC_002655.2 3349347 3350234 R catalyzes the formation of acetaldehyde from ethanolamine; ethanolamine ammonia-lyase small subunit complement(3349347..3350234) Escherichia coli O157:H7 str. EDL933 957670 NP_289002.1 CDS eutB NC_002655.2 3350255 3351616 R ethanolamine ammonia-lyase, heavy chain complement(3350255..3351616) Escherichia coli O157:H7 str. EDL933 957672 NP_289003.1 CDS eutA NC_002655.2 3351628 3353031 R ethanolamine utilization protein EutA; reactivating factor for ethanolamine ammonia lyase complement(3351628..3353031) Escherichia coli O157:H7 str. EDL933 957674 NP_289004.1 CDS eutH NC_002655.2 3353028 3354254 R ethanolamine transport protein complement(3353028..3354254) Escherichia coli O157:H7 str. EDL933 957676 NP_289005.1 CDS eutG NC_002655.2 3354354 3355568 R iron-containing alcohol dehydrogenase complement(3354354..3355568) Escherichia coli O157:H7 str. EDL933 957680 NP_289006.1 CDS eutJ NC_002655.2 3355531 3356367 R hypothetical protein complement(3355531..3356367) Escherichia coli O157:H7 str. EDL933 957682 NP_289007.1 CDS eutE NC_002655.2 3356378 3357781 R ethanolamine utilization; acetaldehyde dehydrogenase complement(3356378..3357781) Escherichia coli O157:H7 str. EDL933 957684 NP_289008.1 CDS cchB NC_002655.2 3357793 3358080 R detox protein complement(3357793..3358080) Escherichia coli O157:H7 str. EDL933 957691 NP_289009.2 CDS cchA NC_002655.2 3358187 3358480 R detox protein complement(3358187..3358480) Escherichia coli O157:H7 str. EDL933 957693 NP_289010.1 CDS eutD NC_002655.2 3358519 3359535 R in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta; phosphotransacetylase complement(3358519..3359535) Escherichia coli O157:H7 str. EDL933 957696 NP_289011.1 CDS Z3715 NC_002655.2 3359532 3360263 R hypothetical protein complement(3359532..3360263) Escherichia coli O157:H7 str. EDL933 957698 NP_289012.1 CDS Z3716 NC_002655.2 3360260 3360961 R ethanolamine utilization protein EutQ complement(3360260..3360961) Escherichia coli O157:H7 str. EDL933 957699 NP_289013.1 CDS Z3717 NC_002655.2 3360936 3361415 R hypothetical protein complement(3360936..3361415) Escherichia coli O157:H7 str. EDL933 957700 NP_289014.1 CDS Z3718 NC_002655.2 3361428 3361835 R hypothetical protein complement(3361428..3361835) Escherichia coli O157:H7 str. EDL933 957702 NP_289015.1 CDS Z3719 NC_002655.2 3362056 3364335 R NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate; malic enzyme complement(3362056..3364335) Escherichia coli O157:H7 str. EDL933 957704 NP_289016.1 CDS talA NC_002655.2 3364624 3365574 D Maintains the balance of metabolites in the pentose-phosphate pathway; transaldolase A 3364624..3365574 Escherichia coli O157:H7 str. EDL933 957711 NP_289017.1 CDS tktB NC_002655.2 3365594 3367597 D catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 3365594..3367597 Escherichia coli O157:H7 str. EDL933 957718 NP_289018.1 CDS Z3722 NC_002655.2 3367692 3368735 R hypothetical protein complement(3367692..3368735) Escherichia coli O157:H7 str. EDL933 957721 NP_289019.1 CDS yffH NC_002655.2 3368861 3369436 R hypothetical protein complement(3368861..3369436) Escherichia coli O157:H7 str. EDL933 957723 NP_289020.1 CDS yffG NC_002655.2 3369504 3371483 R unknown function; in E. coli the aegA gene is regulated by Fnr, NarXL, and NarQ (but not ArcA), induced under anaerobic conditions and repressed in the presence of nitrate (anaerobic); oxidoreductase Fe-S binding subunit complement(3369504..3371483) Escherichia coli O157:H7 str. EDL933 960795 NP_289021.1 CDS narQ NC_002655.2 3371689 3373389 D nitrate/nitrite sensor protein NarQ 3371689..3373389 Escherichia coli O157:H7 str. EDL933 960722 NP_289022.1 CDS acrD NC_002655.2 3373553 3376666 D aminoglycoside/multidrug efflux system 3373553..3376666 Escherichia coli O157:H7 str. EDL933 957725 NP_289023.1 CDS yffB NC_002655.2 3377205 3377561 D hypothetical protein 3377205..3377561 Escherichia coli O157:H7 str. EDL933 957727 NP_289024.1 CDS dapE NC_002655.2 3377565 3378692 D dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica.; succinyl-diaminopimelate desuccinylase 3377565..3378692 Escherichia coli O157:H7 str. EDL933 957867 NP_289025.1 CDS Z3731 NC_002655.2 3378720 3378920 D hypothetical protein 3378720..3378920 Escherichia coli O157:H7 str. EDL933 961036 NP_289026.2 CDS ypfH NC_002655.2 3379001 3379699 R Displays esterase activity toward palmitoyl-CoA and pNP-butyrate; esterase complement(3379001..3379699) Escherichia coli O157:H7 str. EDL933 957734 NP_289027.1 CDS ypfI NC_002655.2 3379773 3381788 R hypothetical protein complement(3379773..3381788) Escherichia coli O157:H7 str. EDL933 957735 NP_289028.1 CDS Z3734 NC_002655.2 3381803 3382666 R hypothetical protein complement(3381803..3382666) Escherichia coli O157:H7 str. EDL933 957737 NP_289029.1 CDS purC NC_002655.2 3382834 3383547 R catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase complement(3382834..3383547) Escherichia coli O157:H7 str. EDL933 957467 NP_289030.2 CDS nlpB NC_002655.2 3383760 3384797 R lipoprotein complement(3383760..3384797) Escherichia coli O157:H7 str. EDL933 959543 NP_289031.1 CDS dapA NC_002655.2 3384811 3385689 R catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase complement(3384811..3385689) Escherichia coli O157:H7 str. EDL933 957738 NP_289032.2 CDS gcvR NC_002655.2 3385835 3386407 D negative transcriptional regulator of the gcvTHP operon; glycine cleavage system transcriptional repressor 3385835..3386407 Escherichia coli O157:H7 str. EDL933 957739 NP_289033.1 CDS bcp NC_002655.2 3386407 3386877 D bacterioferritin comigratory protein; thiol peroxidase; thioredoxin-dependent; hydroperoxide peroxidase; in Escherichia coli this enzyme preferentially reduces linoleic acid hydroperoxide; contains an active site cysteine; thioredoxin-dependent thiol peroxidase 3386407..3386877 Escherichia coli O157:H7 str. EDL933 957792 NP_289034.1 CDS hyfA NC_002655.2 3387091 3387747 D hydrogenase 4 Fe-S subunit 3387091..3387747 Escherichia coli O157:H7 str. EDL933 957091 NP_289035.1 CDS hyfB NC_002655.2 3387747 3389765 D Catalyzes the transfer of electrons from NADH to ubiquinone; hydrogenase 4 subunit B 3387747..3389765 Escherichia coli O157:H7 str. EDL933 957742 NP_289036.1 CDS hyfC NC_002655.2 3389755 3390723 D hydrogenase 4 membrane subunit 3389755..3390723 Escherichia coli O157:H7 str. EDL933 957743 NP_289037.1 CDS hyfD NC_002655.2 3390740 3392179 D hydrogenase 4 subunit D 3390740..3392179 Escherichia coli O157:H7 str. EDL933 956883 NP_289038.1 CDS hyfE NC_002655.2 3392191 3392841 D interacts with formate dehydrogenase to produce an active formate hydrogenlyase complex which cleaves formate to dihydrogen and carbon dioxide; hydrogenase 4 membrane subunit 3392191..3392841 Escherichia coli O157:H7 str. EDL933 957815 NP_289039.1 CDS hyfF NC_002655.2 3392846 3394426 D Catalyzes the transfer of electrons from NADH to ubiquinone; hydrogenase 4 subunit F 3392846..3394426 Escherichia coli O157:H7 str. EDL933 956967 NP_289040.1 CDS hyfG NC_002655.2 3394416 3396131 D hydrogenase 4 subunit 3394416..3396131 Escherichia coli O157:H7 str. EDL933 959545 NP_289041.1 CDS hyfH NC_002655.2 3396141 3396686 D probable electron transfer protein for hydrogenase 4; hydrogenase 4 is believed to be silent in E. coli under conditions tested so far; hydrogenase 4 subunit H 3396141..3396686 Escherichia coli O157:H7 str. EDL933 957744 NP_289042.1 CDS hyfI NC_002655.2 3396683 3397441 D hydrogenase 4 Fe-S subunit 3396683..3397441 Escherichia coli O157:H7 str. EDL933 959571 NP_289043.1 CDS Z3750 NC_002655.2 3397371 3397847 D protein processing element 3397371..3397847 Escherichia coli O157:H7 str. EDL933 961407 NP_289044.1 CDS hyfR NC_002655.2 3397877 3399916 D 2-component regulator 3397877..3399916 Escherichia coli O157:H7 str. EDL933 958161 NP_289045.1 CDS focB NC_002655.2 3399913 3400761 D inner membrane protein presumed to act as a formate transporter; member of the hyf operon; formate transporter 3399913..3400761 Escherichia coli O157:H7 str. EDL933 961354 NP_289046.1 CDS perM NC_002655.2 3400799 3401860 R permease complement(3400799..3401860) Escherichia coli O157:H7 str. EDL933 957749 NP_289047.1 CDS Z3757 NC_002655.2 3402073 3403536 D hypothetical protein 3402073..3403536 Escherichia coli O157:H7 str. EDL933 957750 NP_289048.1 CDS Z3758 NC_002655.2 3403557 3403916 D oxidoreductase 3403557..3403916 Escherichia coli O157:H7 str. EDL933 957753 NP_289049.1 CDS Z3759 NC_002655.2 3404054 3404800 R controls initiation of DNA replication by inhibiting re-initiation of replication, promotes hydrolysis of DnaA-bound ATP; DNA replication initiation factor complement(3404054..3404800) Escherichia coli O157:H7 str. EDL933 957755 NP_289050.1 CDS uraA NC_002655.2 3404850 3406139 R uracil transporter complement(3404850..3406139) Escherichia coli O157:H7 str. EDL933 957761 NP_289051.2 CDS upp NC_002655.2 3406225 3406851 R Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase complement(3406225..3406851) Escherichia coli O157:H7 str. EDL933 961291 NP_289052.1 CDS purM NC_002655.2 3407176 3408213 D catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 3407176..3408213 Escherichia coli O157:H7 str. EDL933 961316 NP_289053.1 CDS purN NC_002655.2 3408213 3408851 D glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate; phosphoribosylglycinamide formyltransferase 3408213..3408851 Escherichia coli O157:H7 str. EDL933 961321 NP_289054.1 CDS ppk NC_002655.2 3409022 3411088 D catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate; polyphosphate kinase 3409022..3411088 Escherichia coli O157:H7 str. EDL933 957762 NP_289055.1 CDS ppx NC_002655.2 3411093 3412634 D exopolyphosphatase 3411093..3412634 Escherichia coli O157:H7 str. EDL933 957770 NP_289056.1 CDS Z3766 NC_002655.2 3412673 3414916 R cytochrome C biogenesis protein complement(3412673..3414916) Escherichia coli O157:H7 str. EDL933 958361 NP_289057.1 CDS Z3767 NC_002655.2 3415098 3415250 R No significant matches; hypothetical protein complement(3415098..3415250) Escherichia coli O157:H7 str. EDL933 958386 NP_289058.1 CDS Z3768 NC_002655.2 3415268 3415459 D hypothetical protein 3415268..3415459 Escherichia coli O157:H7 str. EDL933 957900 NP_289059.1 CDS Z3769 NC_002655.2 3415770 3416288 D outer membrane lipoprotein 3415770..3416288 Escherichia coli O157:H7 str. EDL933 959398 NP_289060.1 CDS Z3770 NC_002655.2 3416304 3416843 D hypothetical protein 3416304..3416843 Escherichia coli O157:H7 str. EDL933 957775 NP_289061.1 CDS guaA NC_002655.2 3416936 3418513 R contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase complement(3416936..3418513) Escherichia coli O157:H7 str. EDL933 957778 NP_289062.1 CDS guaB NC_002655.2 3418582 3420048 R catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase complement(3418582..3420048) Escherichia coli O157:H7 str. EDL933 957789 NP_289063.1 CDS xseA NC_002655.2 3420210 3421580 D bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit 3420210..3421580 Escherichia coli O157:H7 str. EDL933 959509 NP_289064.2 CDS engA NC_002655.2 3421861 3423333 R EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA complement(3421861..3423333) Escherichia coli O157:H7 str. EDL933 959526 NP_289065.1 CDS Z3775 NC_002655.2 3423451 3424629 R with YaeT, YfiO, and NlpB forms a complex involved in outer membrane protein biogenesis; outer membrane protein assembly complex subunit YfgL complement(3423451..3424629) Escherichia coli O157:H7 str. EDL933 961353 NP_289066.1 CDS Z3776 NC_002655.2 3424640 3425260 R hypothetical protein complement(3424640..3425260) Escherichia coli O157:H7 str. EDL933 961303 NP_289067.1 CDS hisS NC_002655.2 3425278 3426552 R catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase complement(3425278..3426552) Escherichia coli O157:H7 str. EDL933 957790 NP_289068.1 CDS ispG NC_002655.2 3426663 3427781 R catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase complement(3426663..3427781) Escherichia coli O157:H7 str. EDL933 957794 NP_289069.1 CDS yfgA NC_002655.2 3427808 3428821 R cytoskeletal protein RodZ complement(3427808..3428821) Escherichia coli O157:H7 str. EDL933 957798 NP_289070.1 CDS yfgB NC_002655.2 3429106 3430260 R 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance; ribosomal RNA large subunit methyltransferase N complement(3429106..3430260) Escherichia coli O157:H7 str. EDL933 957803 NP_289071.1 CDS ndk NC_002655.2 3430410 3430841 R catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase complement(3430410..3430841) Escherichia coli O157:H7 str. EDL933 957806 NP_289072.1 CDS Z3782 NC_002655.2 3430982 3431560 R No significant matches; hypothetical protein complement(3430982..3431560) Escherichia coli O157:H7 str. EDL933 960730 NP_289073.1 CDS Z3783 NC_002655.2 3431836 3432657 R dimethyl sulfoxide reductase subunit C complement(3431836..3432657) Escherichia coli O157:H7 str. EDL933 957807 NP_289074.1 CDS Z3784 NC_002655.2 3432650 3433087 R dimethyl sulfoxide reductase subunit B complement(3432650..3433087) Escherichia coli O157:H7 str. EDL933 957809 NP_289075.1 CDS Z3785 NC_002655.2 3433276 3435657 R dimethyl sulfoxide reductase subunit A complement(3433276..3435657) Escherichia coli O157:H7 str. EDL933 957810 NP_289076.2 CDS pbpC NC_002655.2 3435821 3438133 R penicillin-insensitive transglycosylase/transpeptidase; penicillin-binding protein 1C complement(3435821..3438133) Escherichia coli O157:H7 str. EDL933 957817 NP_289077.1 CDS Z3787 NC_002655.2 3438134 3443095 R hypothetical protein complement(3438134..3443095) Escherichia coli O157:H7 str. EDL933 957818 NP_289078.2 CDS sseA NC_002655.2 3443302 3444147 D catalyzes the transfer of a sulfur ion to cyanide or to other thiol compounds; 3-mercaptopyruvate sulfurtransferase 3443302..3444147 Escherichia coli O157:H7 str. EDL933 957822 NP_289079.1 CDS sseB NC_002655.2 3444647 3445456 R enhances serine sensitivity caused by inhibition of homoserine dehydrogenase I; enhanced serine sensitivity protein SseB complement(3444647..3445456) Escherichia coli O157:H7 str. EDL933 957827 NP_289080.2 CDS pepB NC_002655.2 3445567 3446850 R catalyzes the removal of an N-terminal amino acid from a peptide or arylamide; aminopeptidase complement(3445567..3446850) Escherichia coli O157:H7 str. EDL933 959184 NP_289081.1 CDS yfhJ NC_002655.2 3447028 3447228 R hypothetical protein complement(3447028..3447228) Escherichia coli O157:H7 str. EDL933 959402 NP_289082.1 CDS fdx NC_002655.2 3447240 3447575 R [2FE-2S] ferredoxin, electron carrer protein complement(3447240..3447575) Escherichia coli O157:H7 str. EDL933 957832 NP_289083.1 CDS hscA NC_002655.2 3447577 3449427 R involved in the maturation of iron-sulfur cluster-containing proteins; chaperone protein HscA complement(3447577..3449427) Escherichia coli O157:H7 str. EDL933 957772 NP_289084.1 CDS hscB NC_002655.2 3449444 3449959 R J-type co-chaperone that regulates the ATPase and peptide-binding activity of Hsc66 chaperone; may function in biogenesis of iron-sulfur proteins; co-chaperone HscB complement(3449444..3449959) Escherichia coli O157:H7 str. EDL933 957840 NP_289085.1 CDS iscA NC_002655.2 3450055 3450378 R forms iron-sulfur clusters of ferredoxin [2FE-2S]; binds iron in the presence of the thioredoxin reductase system; forms homodimers and tetramers; similar to SufA protein; iron-sulfur cluster assembly protein complement(3450055..3450378) Escherichia coli O157:H7 str. EDL933 957129 NP_289086.1 CDS Z3796 NC_002655.2 3450395 3450781 R scaffold protein complement(3450395..3450781) Escherichia coli O157:H7 str. EDL933 957837 NP_289087.1 CDS yfhO NC_002655.2 3450809 3452047 R catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis; cysteine desulfurase complement(3450809..3452047) Escherichia coli O157:H7 str. EDL933 957843 NP_289088.1 CDS Z3798 NC_002655.2 3452135 3452623 R regulates the expression of the iscRSUA operon; DNA-binding transcriptional regulator IscR complement(3452135..3452623) Escherichia coli O157:H7 str. EDL933 957689 NP_289089.1 CDS Z3799 NC_002655.2 3452924 3453661 R ATP synthase subunit beta complement(3452924..3453661) Escherichia coli O157:H7 str. EDL933 957846 NP_289090.1 CDS Z3802 NC_002655.2 3454701 3455582 D hydrolase 3454701..3455582 Escherichia coli O157:H7 str. EDL933 957848 NP_289091.2 CDS csiE NC_002655.2 3455773 3457053 D stationary phase inducible protein CsiE 3455773..3457053 Escherichia coli O157:H7 str. EDL933 958388 NP_289092.1 CDS hcaT NC_002655.2 3457045 3458184 R transporter of 3-phenylpropionate across the inner membrane; member of the major facilitator superfamily of transporters; 3-phenylpropionic acid transporter complement(3457045..3458184) Escherichia coli O157:H7 str. EDL933 958412 NP_289093.1 CDS hcaR NC_002655.2 3458345 3459235 R activator of 3-phenylpropionic acid catabolism; DNA-binding transcriptional regulator HcaR complement(3458345..3459235) Escherichia coli O157:H7 str. EDL933 957329 NP_289094.1 CDS hcaA1 NC_002655.2 3459371 3460732 D large terminal subunit of phenylpropionate dioxygenase 3459371..3460732 Escherichia coli O157:H7 str. EDL933 957853 NP_289095.1 CDS hcaA2 NC_002655.2 3460729 3461247 D 3-phenylpropionate dioxygenase subunit beta 3460729..3461247 Escherichia coli O157:H7 str. EDL933 957854 NP_289096.1 CDS hcaC NC_002655.2 3461247 3461567 D 3-phenylpropionate dioxygenase ferredoxin subunit 3461247..3461567 Escherichia coli O157:H7 str. EDL933 957855 NP_289097.1 CDS hcaB NC_002655.2 3461564 3462376 D Converts cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol (PP-dihydrodiol) into 3-(2,3-dihydroxylphenyl)propionate; 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase 3461564..3462376 Escherichia coli O157:H7 str. EDL933 960726 NP_289098.1 CDS hcaD NC_002655.2 3462386 3463588 D phenylpropionate dioxygenase ferredoxin reductase subunit 3462386..3463588 Escherichia coli O157:H7 str. EDL933 958539 NP_289099.1 CDS yphA NC_002655.2 3463640 3464107 D hypothetical protein 3463640..3464107 Escherichia coli O157:H7 str. EDL933 957862 NP_289100.1 CDS yphB NC_002655.2 3464155 3465027 R hypothetical protein complement(3464155..3465027) Escherichia coli O157:H7 str. EDL933 957869 NP_289101.1 CDS yphC NC_002655.2 3465039 3466133 R Zn-dependent dehydrogenase complement(3465039..3466133) Escherichia coli O157:H7 str. EDL933 959623 NP_289102.1 CDS yphD NC_002655.2 3466166 3467164 R transport system permease complement(3466166..3467164) Escherichia coli O157:H7 str. EDL933 957871 NP_289103.1 CDS yphE NC_002655.2 3467189 3468700 R ABC transporter ATP-binding protein complement(3467189..3468700) Escherichia coli O157:H7 str. EDL933 961180 NP_289104.1 CDS yphF NC_002655.2 3468723 3469706 R LACI-type transcriptional regulator complement(3468723..3469706) Escherichia coli O157:H7 str. EDL933 956939 NP_289105.1 CDS yphG NC_002655.2 3469803 3473177 R hypothetical protein complement(3469803..3473177) Escherichia coli O157:H7 str. EDL933 957875 NP_289106.1 CDS yphH NC_002655.2 3473196 3474395 D NAGC-like transcriptional regulator 3473196..3474395 Escherichia coli O157:H7 str. EDL933 957880 NP_289107.1 CDS glyA NC_002655.2 3474458 3475711 R catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase complement(3474458..3475711) Escherichia coli O157:H7 str. EDL933 957380 NP_289108.1 CDS hmpA NC_002655.2 3476039 3477229 D flavohemoprotein; catalyzes the formation of nitrate from nitric oxide; can also catalyze the reduction of dihydropteridine; nitric oxide dioxygenase 3476039..3477229 Escherichia coli O157:H7 str. EDL933 959263 NP_289109.1 CDS glnB NC_002655.2 3477274 3477612 R indirectly regulates nitrogen metabolism; at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; nitrogen regulatory protein P-II 1 complement(3477274..3477612) Escherichia coli O157:H7 str. EDL933 961286 NP_289110.1 CDS yfhA NC_002655.2 3477673 3479007 R 2-component transcriptional regulator complement(3477673..3479007) Escherichia coli O157:H7 str. EDL933 957883 NP_289111.1 CDS yfhG NC_002655.2 3478997 3479710 R hypothetical protein complement(3478997..3479710) Escherichia coli O157:H7 str. EDL933 957887 NP_289112.1 CDS yfhK NC_002655.2 3479875 3481365 R 2-component sensor protein complement(3479875..3481365) Escherichia coli O157:H7 str. EDL933 957893 NP_289113.1 CDS purL NC_002655.2 3481878 3485765 R catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase complement(3481878..3485765) Escherichia coli O157:H7 str. EDL933 957901 NP_289114.1 CDS yfhD NC_002655.2 3486160 3487578 D YfhD; uncharacterized member of the transglycosylase slt family; part of the rob operon, which plays a role in cellular resistance to antibiotics, bactericidal agents, and organic solvents; unknown function; transglycosylase 3486160..3487578 Escherichia coli O157:H7 str. EDL933 958091 NP_289115.1 CDS yfhC NC_002655.2 3487575 3488111 R tRNA-specific adenosine deaminase complement(3487575..3488111) Escherichia coli O157:H7 str. EDL933 958078 NP_289116.2 CDS yfhB NC_002655.2 3488136 3488771 R hypothetical protein complement(3488136..3488771) Escherichia coli O157:H7 str. EDL933 957606 NP_289117.2 CDS yfhH NC_002655.2 3488980 3489828 D DNA-binding transcriptional regulator 3488980..3489828 Escherichia coli O157:H7 str. EDL933 957907 NP_289118.1 CDS yfhL NC_002655.2 3489884 3490144 D hypothetical protein 3489884..3490144 Escherichia coli O157:H7 str. EDL933 957913 NP_289119.1 CDS Z3843 NC_002655.2 3490416 3490568 R No significant matches; hypothetical protein complement(3490416..3490568) Escherichia coli O157:H7 str. EDL933 957917 NP_289120.1 CDS acpS NC_002655.2 3490841 3491221 R Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase complement(3490841..3491221) Escherichia coli O157:H7 str. EDL933 957918 NP_289121.1 CDS pdxJ NC_002655.2 3491221 3491952 R involved in the de novo synthesis of pyridoxine (Vitamin B6); pyridoxine 5'-phosphate synthase complement(3491221..3491952) Escherichia coli O157:H7 str. EDL933 957924 NP_289122.1 CDS recO NC_002655.2 3491964 3492692 R involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO complement(3491964..3492692) Escherichia coli O157:H7 str. EDL933 957925 NP_289123.1 CDS era NC_002655.2 3492704 3493609 R Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era complement(3492704..3493609) Escherichia coli O157:H7 str. EDL933 957928 NP_289124.1 CDS rnc NC_002655.2 3493606 3494286 R cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III complement(3493606..3494286) Escherichia coli O157:H7 str. EDL933 957930 NP_289125.1 CDS Z3849 NC_002655.2 3494344 3494508 D No significant matches; hypothetical protein 3494344..3494508 Escherichia coli O157:H7 str. EDL933 957939 NP_289126.1 CDS lepB NC_002655.2 3494559 3495533 R catalyzes the cleavage of the amino-terminal leader peptide from secretory proteins; signal peptidase I complement(3494559..3495533) Escherichia coli O157:H7 str. EDL933 957941 NP_289127.1 CDS lepA NC_002655.2 3495549 3497348 R binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA complement(3495549..3497348) Escherichia coli O157:H7 str. EDL933 957944 NP_289128.1 CDS rseC NC_002655.2 3497546 3498025 R involved in the reduction of the SoxR iron-sulfur cluster; SoxR reducing system protein RseC complement(3497546..3498025) Escherichia coli O157:H7 str. EDL933 957946 NP_289129.1 CDS rseB NC_002655.2 3498022 3498978 R periplasmic protein; interacts with the C-terminal domain of RseA and stimulates RseA binding to sigmaE via the cytoplasmic RseA N-terminal domain which then sequesters sigmaE in the membrane thereby preventing sigmaE associated with core RNAP; periplasmic negative regulator of sigmaE complement(3498022..3498978) Escherichia coli O157:H7 str. EDL933 957951 NP_289130.1 CDS rseA NC_002655.2 3498978 3499616 R anti-RNA polymerase sigma factor SigE complement(3498978..3499616) Escherichia coli O157:H7 str. EDL933 957954 NP_289131.1 CDS rpoE NC_002655.2 3499649 3500224 R Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response; RNA polymerase sigma factor RpoE complement(3499649..3500224) Escherichia coli O157:H7 str. EDL933 957965 NP_289132.1 CDS nadB NC_002655.2 3500632 3502254 D catalyzes the formation of oxaloacetate from L-aspartate; L-aspartate oxidase 3500632..3502254 Escherichia coli O157:H7 str. EDL933 957968 NP_289133.1 CDS yfiC NC_002655.2 3502239 3503096 R hypothetical protein complement(3502239..3503096) Escherichia coli O157:H7 str. EDL933 959275 NP_289134.1 CDS srmB NC_002655.2 3503108 3504442 D facilitates an early step in the assembly of the 50S subunit of the ribosome; ATP-dependent RNA helicase SrmB 3503108..3504442 Escherichia coli O157:H7 str. EDL933 959293 NP_289135.1 CDS yfiE NC_002655.2 3504475 3505401 R LysR family transcriptional regulator complement(3504475..3505401) Escherichia coli O157:H7 str. EDL933 956956 NP_289136.1 CDS yfiK NC_002655.2 3505459 3506046 D neutral amino-acid efflux protein 3505459..3506046 Escherichia coli O157:H7 str. EDL933 959378 NP_289137.1 CDS yfiD NC_002655.2 3506102 3506485 R stress-induced glycyl radical protein that can replace an oxidatively damaged pyruvate formate-lyase subunit; autonomous glycyl radical cofactor GrcA complement(3506102..3506485) Escherichia coli O157:H7 str. EDL933 957971 NP_289138.1 CDS ung NC_002655.2 3506790 3507479 D Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 3506790..3507479 Escherichia coli O157:H7 str. EDL933 957972 NP_289139.1 CDS yfiF NC_002655.2 3507527 3508564 R methyltransferase complement(3507527..3508564) Escherichia coli O157:H7 str. EDL933 957978 NP_289140.1 CDS Z3866 NC_002655.2 3508554 3508757 R No significant matches; hypothetical protein complement(3508554..3508757) Escherichia coli O157:H7 str. EDL933 957979 NP_289141.1 CDS trxC NC_002655.2 3508771 3509190 D thioredoxin 3508771..3509190 Escherichia coli O157:H7 str. EDL933 957981 NP_289142.1 CDS yfiP NC_002655.2 3509235 3509957 D hypothetical protein 3509235..3509957 Escherichia coli O157:H7 str. EDL933 957983 NP_289143.1 CDS yfiQ NC_002655.2 3509989 3512649 D hypothetical protein 3509989..3512649 Escherichia coli O157:H7 str. EDL933 957987 NP_289144.1 CDS pssA NC_002655.2 3512760 3514118 D catalyzes de novo synthesis of phosphatidylserine from CDP-diacylglycerol and L-serine which leads eventually to the production of phosphatidylethanolamine; bounds to the ribosome; phosphatidylserine synthase 3512760..3514118 Escherichia coli O157:H7 str. EDL933 957988 NP_289145.1 CDS yfiM NC_002655.2 3514215 3514487 D hypothetical protein 3514215..3514487 Escherichia coli O157:H7 str. EDL933 960432 NP_289146.1 CDS kgtP NC_002655.2 3514484 3515782 R alpha-ketoglutarate transporter complement(3514484..3515782) Escherichia coli O157:H7 str. EDL933 959504 NP_289147.1 CDS clpB NC_002655.2 3521568 3524153 R protein disaggregation chaperone complement(3521568..3524153) Escherichia coli O157:H7 str. EDL933 958006 NP_289148.1 CDS yfiH NC_002655.2 3524271 3525002 R hypothetical protein complement(3524271..3525002) Escherichia coli O157:H7 str. EDL933 958009 NP_289149.1 CDS rluD NC_002655.2 3524999 3525979 R responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA; 23S rRNA pseudouridine synthase D complement(3524999..3525979) Escherichia coli O157:H7 str. EDL933 960934 NP_289150.1 CDS Z3889 NC_002655.2 3526114 3526851 D with YaeT, NlpB and YfgL forms a complex involved in the proper assembly and/or targeting of OMPs to the outer membrane; involved in resistance to ampicillin and tetracycline; outer membrane protein assembly complex subunit YfiO 3526114..3526851 Escherichia coli O157:H7 str. EDL933 960368 NP_289151.1 CDS yfiA NC_002655.2 3527122 3527463 D associated with 30S ribosomal subunit; interferes with translation elongation; translation inhibitor protein RaiA 3527122..3527463 Escherichia coli O157:H7 str. EDL933 956875 NP_289152.1 CDS pheA NC_002655.2 3527713 3528873 D catalyzing the formation of prephenate from chorismate and the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis; bifunctional chorismate mutase/prephenate dehydratase 3527713..3528873 Escherichia coli O157:H7 str. EDL933 958015 NP_289153.1 CDS tyrA NC_002655.2 3528916 3530037 R catalyzes the formation of prephenate from chorismate and the formation of 4-hydroxyphenylpyruvate from prephenate in tyrosine biosynthesis; bifunctional chorismate mutase/prephenate dehydrogenase complement(3528916..3530037) Escherichia coli O157:H7 str. EDL933 958018 NP_289154.1 CDS aroF NC_002655.2 3530048 3531118 R catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase complement(3530048..3531118) Escherichia coli O157:H7 str. EDL933 958019 NP_289155.1 CDS yfiL NC_002655.2 3531289 3531693 D hypothetical protein 3531289..3531693 Escherichia coli O157:H7 str. EDL933 957905 NP_289156.1 CDS Z3897 NC_002655.2 3531843 3532361 D hypothetical protein 3531843..3532361 Escherichia coli O157:H7 str. EDL933 956960 NP_289157.1 CDS yfiN NC_002655.2 3532351 3533577 D hypothetical protein 3532351..3533577 Escherichia coli O157:H7 str. EDL933 958022 NP_289158.1 CDS yfiB NC_002655.2 3533593 3534075 D outer membrane lipoprotein 3533593..3534075 Escherichia coli O157:H7 str. EDL933 958027 NP_289159.1 CDS rplS NC_002655.2 3534152 3534499 R this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 complement(3534152..3534499) Escherichia coli O157:H7 str. EDL933 958030 NP_289160.1 CDS trmD NC_002655.2 3534541 3535308 R methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase complement(3534541..3535308) Escherichia coli O157:H7 str. EDL933 958031 NP_289161.2 CDS rimM NC_002655.2 3535339 3535887 R Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM complement(3535339..3535887) Escherichia coli O157:H7 str. EDL933 958032 NP_289162.1 CDS rpsP NC_002655.2 3535906 3536154 R binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 complement(3535906..3536154) Escherichia coli O157:H7 str. EDL933 956739 NP_289163.1 CDS ffh NC_002655.2 3536291 3537652 R with 4.5S RNA forms a signal recognition particle involved in targeting and integration of inner membrane proteins; signal recognition particle protein complement(3536291..3537652) Escherichia coli O157:H7 str. EDL933 959351 NP_289164.1 CDS Z3905 NC_002655.2 3537744 3538610 D hypothetical protein 3537744..3538610 Escherichia coli O157:H7 str. EDL933 958735 NP_289165.1 CDS yfjD NC_002655.2 3538656 3539918 D hypothetical protein 3538656..3539918 Escherichia coli O157:H7 str. EDL933 959626 NP_289166.1 CDS grpE NC_002655.2 3539973 3540566 R with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE complement(3539973..3540566) Escherichia coli O157:H7 str. EDL933 957103 NP_289167.1 CDS ppnK NC_002655.2 3540689 3541567 D catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 3540689..3541567 Escherichia coli O157:H7 str. EDL933 958034 NP_289168.1 CDS recN NC_002655.2 3541653 3543314 D recombination and repair protein 3541653..3543314 Escherichia coli O157:H7 str. EDL933 958036 NP_289169.1 CDS smpA NC_002655.2 3543652 3543804 D small membrane protein A 3543652..3543804 Escherichia coli O157:H7 str. EDL933 957902 NP_289170.2 CDS Z3911 NC_002655.2 3543866 3544156 R hypothetical protein complement(3543866..3544156) Escherichia coli O157:H7 str. EDL933 958546 NP_289171.1 CDS Z3912 NC_002655.2 3544146 3544622 R hypothetical protein complement(3544146..3544622) Escherichia coli O157:H7 str. EDL933 958037 NP_289172.1 CDS smpB NC_002655.2 3544754 3545236 D binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 3544754..3545236 Escherichia coli O157:H7 str. EDL933 958044 NP_289173.1 CDS Z3916 NC_002655.2 3546082 3546330 D hypothetical protein 3546082..3546330 Escherichia coli O157:H7 str. EDL933 956667 NP_289174.1 CDS Z3917 NC_002655.2 3546530 3546616 R No significant matches; hypothetical protein complement(3546530..3546616) Escherichia coli O157:H7 str. EDL933 958049 NP_289175.1 CDS Z3918 NC_002655.2 3546832 3547422 R chaperone protein complement(3546832..3547422) Escherichia coli O157:H7 str. EDL933 958050 NP_289176.1 CDS Z3919 NC_002655.2 3547605 3548255 D hypothetical protein 3547605..3548255 Escherichia coli O157:H7 str. EDL933 958051 NP_289177.1 CDS Z3920 NC_002655.2 3548334 3549392 D hypothetical protein 3548334..3549392 Escherichia coli O157:H7 str. EDL933 958058 NP_289178.1 CDS Z3921 NC_002655.2 3549522 3550001 R hypothetical protein complement(3549522..3550001) Escherichia coli O157:H7 str. EDL933 958060 NP_289179.1 CDS Z3922 NC_002655.2 3550280 3550606 D transposase 3550280..3550606 Escherichia coli O157:H7 str. EDL933 958064 NP_289180.1 CDS Z3923 NC_002655.2 3550606 3550812 D hypothetical protein 3550606..3550812 Escherichia coli O157:H7 str. EDL933 958065 NP_289181.1 CDS Z3924 NC_002655.2 3550847 3551065 D transposase 3550847..3551065 Escherichia coli O157:H7 str. EDL933 957279 NP_289182.1 CDS Z3925 NC_002655.2 3551085 3551495 D transposase 3551085..3551495 Escherichia coli O157:H7 str. EDL933 959339 NP_289183.1 CDS Z3926 NC_002655.2 3551577 3552050 R hypothetical protein complement(3551577..3552050) Escherichia coli O157:H7 str. EDL933 957556 NP_289184.1 CDS Z3927 NC_002655.2 3552256 3553428 R hypothetical protein complement(3552256..3553428) Escherichia coli O157:H7 str. EDL933 958212 NP_289185.1 CDS Z3929 NC_002655.2 3553836 3553946 R No significant matches; hypothetical protein complement(3553836..3553946) Escherichia coli O157:H7 str. EDL933 958067 NP_289186.1 CDS Z3931 NC_002655.2 3554089 3554847 R hypothetical protein complement(3554089..3554847) Escherichia coli O157:H7 str. EDL933 958068 NP_289187.1 CDS Z3932 NC_002655.2 3555085 3555708 R antiterminator of prophage CP-933Y complement(3555085..3555708) Escherichia coli O157:H7 str. EDL933 958069 NP_289188.1 CDS Z3933 NC_002655.2 3555705 3556370 R hypothetical protein complement(3555705..3556370) Escherichia coli O157:H7 str. EDL933 958070 NP_289189.1 CDS Z3934 NC_002655.2 3556367 3556567 R hypothetical protein complement(3556367..3556567) Escherichia coli O157:H7 str. EDL933 958071 NP_289190.1 CDS Z3935 NC_002655.2 3556953 3557558 R hypothetical protein complement(3556953..3557558) Escherichia coli O157:H7 str. EDL933 958687 NP_289191.1 CDS tra8_3 NC_002655.2 3557855 3558610 D IS30 transposase 3557855..3558610 Escherichia coli O157:H7 str. EDL933 961454 NP_289192.1 CDS Z3937 NC_002655.2 3558670 3558948 D No significant matches; hypothetical protein 3558670..3558948 Escherichia coli O157:H7 str. EDL933 958072 NP_289193.1 CDS Z3938 NC_002655.2 3559119 3559238 D No significant matches; hypothetical protein 3559119..3559238 Escherichia coli O157:H7 str. EDL933 958077 NP_289194.1 CDS Z3939 NC_002655.2 3559338 3560246 R No significant matches; hypothetical protein complement(3559338..3560246) Escherichia coli O157:H7 str. EDL933 958079 NP_289195.1 CDS Z3940 NC_002655.2 3560643 3561113 R No significant matches; hypothetical protein complement(3560643..3561113) Escherichia coli O157:H7 str. EDL933 958092 NP_289196.1 CDS Z3941 NC_002655.2 3561154 3561375 R No significant matches; hypothetical protein complement(3561154..3561375) Escherichia coli O157:H7 str. EDL933 957282 NP_289197.1 CDS Z3942 NC_002655.2 3561775 3563187 R No significant matches; hypothetical protein complement(3561775..3563187) Escherichia coli O157:H7 str. EDL933 958080 NP_289198.1 CDS Z3943 NC_002655.2 3563184 3564509 R No significant matches; hypothetical protein complement(3563184..3564509) Escherichia coli O157:H7 str. EDL933 956686 NP_289199.1 CDS Z3945 NC_002655.2 3564664 3565707 R hypothetical protein complement(3564664..3565707) Escherichia coli O157:H7 str. EDL933 959361 NP_289200.1 CDS Z3946 NC_002655.2 3566030 3566236 R DNA binding protein complement(3566030..3566236) Escherichia coli O157:H7 str. EDL933 956685 NP_289201.1 CDS Z3947 NC_002655.2 3566336 3567187 R No significant matches; hypothetical protein complement(3566336..3567187) Escherichia coli O157:H7 str. EDL933 960720 NP_289202.1 CDS ypjA NC_002655.2 3567614 3572200 R ABC transporter ATP-binding protein complement(3567614..3572200) Escherichia coli O157:H7 str. EDL933 959506 NP_289203.1 CDS Z3949 NC_002655.2 3572539 3572682 R hypothetical protein complement(3572539..3572682) Escherichia coli O157:H7 str. EDL933 959496 NP_289204.1 CDS Z3950 NC_002655.2 3573136 3574485 R hypothetical protein complement(3573136..3574485) Escherichia coli O157:H7 str. EDL933 958085 NP_289205.1 CDS Z3951 NC_002655.2 3574993 3575145 R No significant matches; hypothetical protein complement(3574993..3575145) Escherichia coli O157:H7 str. EDL933 961325 NP_289206.1 CDS Z3954 NC_002655.2 3575873 3577111 D hypothetical protein 3575873..3577111 Escherichia coli O157:H7 str. EDL933 958089 NP_289207.1 CDS Z3955 NC_002655.2 3577118 3578125 D hypothetical protein 3577118..3578125 Escherichia coli O157:H7 str. EDL933 958090 NP_289208.2 CDS Z3956 NC_002655.2 3578462 3579439 D in Escherichia coli this gene is induced by carbon starvation and depends on sigma S and cAMP-CRP; the structure of the Gab protein shows it is a member of non-heme iron (II)-dependent oxygenase superfamily which includes clavamini acid synthases; forms homotetramers in solution; hypothetical protein 3578462..3579439 Escherichia coli O157:H7 str. EDL933 958097 NP_289209.1 CDS ygaF NC_002655.2 3579393 3580727 D catalyzed the formation of 2-ketoglutarate from 2-hydroxyglutarate; hydroxyglutarate oxidase 3579393..3580727 Escherichia coli O157:H7 str. EDL933 958098 NP_289210.1 CDS gabD NC_002655.2 3580750 3582198 D catalyzes the formation of succinate from succinate semialdehyde; NADP dependent; succinate-semialdehyde dehydrogenase I 3580750..3582198 Escherichia coli O157:H7 str. EDL933 958101 NP_289211.1 CDS gabT NC_002655.2 3582212 3583492 D catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate; 4-aminobutyrate aminotransferase 3582212..3583492 Escherichia coli O157:H7 str. EDL933 958102 NP_289212.1 CDS gabP NC_002655.2 3583730 3585130 D gamma-aminobutyrate transporter 3583730..3585130 Escherichia coli O157:H7 str. EDL933 958106 NP_289214.2 CDS ygaE NC_002655.2 3585151 3585813 D regulator of gab gene expression; DNA-binding transcriptional regulator CsiR 3585151..3585813 Escherichia coli O157:H7 str. EDL933 960476 NP_289215.1 CDS ygaU NC_002655.2 3585814 3586263 R LysM domain/BON superfamily protein complement(3585814..3586263) Escherichia coli O157:H7 str. EDL933 958075 NP_289216.1 CDS Z3965 NC_002655.2 3586347 3586505 R hypothetical protein complement(3586347..3586505) Escherichia coli O157:H7 str. EDL933 958066 NP_289217.1 CDS Z3966 NC_002655.2 3586688 3586987 D hypothetical protein 3586688..3586987 Escherichia coli O157:H7 str. EDL933 958107 NP_289218.1 CDS ygaP NC_002655.2 3586997 3587515 D hypothetical protein 3586997..3587515 Escherichia coli O157:H7 str. EDL933 958109 NP_289219.1 CDS stpA NC_002655.2 3587568 3587972 R DNA binding protein complement(3587568..3587972) Escherichia coli O157:H7 str. EDL933 958518 NP_289220.1 CDS Z3970 NC_002655.2 3588640 3589089 D hypothetical protein 3588640..3589089 Escherichia coli O157:H7 str. EDL933 959318 NP_289221.1 CDS ygaC NC_002655.2 3589126 3589470 R hypothetical protein complement(3589126..3589470) Escherichia coli O157:H7 str. EDL933 956958 NP_289222.1 CDS ygaM NC_002655.2 3589610 3589951 D hypothetical protein 3589610..3589951 Escherichia coli O157:H7 str. EDL933 958113 NP_289223.1 CDS Z3973 NC_002655.2 3590101 3591435 R hypothetical protein complement(3590101..3591435) Escherichia coli O157:H7 str. EDL933 958118 NP_289224.1 CDS Z3974 NC_002655.2 3591523 3591954 D hypothetical protein 3591523..3591954 Escherichia coli O157:H7 str. EDL933 958441 NP_289225.1 CDS nrdH NC_002655.2 3592163 3592408 D glutaredoxin-like protein 3592163..3592408 Escherichia coli O157:H7 str. EDL933 958447 NP_289226.1 CDS nrdI NC_002655.2 3592405 3592815 D in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF; ribonucleotide reductase stimulatory protein 3592405..3592815 Escherichia coli O157:H7 str. EDL933 957903 NP_289227.1 CDS nrdE NC_002655.2 3592788 3594932 D Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 3592788..3594932 Escherichia coli O157:H7 str. EDL933 958123 NP_289228.1 CDS nrdF NC_002655.2 3594942 3595901 D B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta 3594942..3595901 Escherichia coli O157:H7 str. EDL933 958124 NP_289229.1 CDS proV NC_002655.2 3596257 3597459 D with ProWX is involved in the high-affinity uptake of glycine betaine; glycine betaine transporter ATP-binding subunit 3596257..3597459 Escherichia coli O157:H7 str. EDL933 958127 NP_289230.1 CDS proW NC_002655.2 3597452 3598516 D with ProVX is involved in the high-affinity uptake of glycine betaine; glycine betaine transporter membrane protein 3597452..3598516 Escherichia coli O157:H7 str. EDL933 958130 NP_289231.1 CDS proX NC_002655.2 3598573 3599565 D with ProVW, part of the high-affinity transport system for the osmoprotectant glycine betaine; glycine betaine transporter periplasmic subunit 3598573..3599565 Escherichia coli O157:H7 str. EDL933 958117 NP_289232.1 CDS Z3982 NC_002655.2 3599757 3600941 D transporter 3599757..3600941 Escherichia coli O157:H7 str. EDL933 958108 NP_289233.1 CDS Z3983 NC_002655.2 3601065 3601802 D hypothetical protein 3601065..3601802 Escherichia coli O157:H7 str. EDL933 958105 NP_289234.1 CDS ygaH NC_002655.2 3601792 3602127 D hypothetical protein 3601792..3602127 Escherichia coli O157:H7 str. EDL933 958131 NP_289235.1 CDS emrR NC_002655.2 3602218 3602748 D DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux; negative regulator of the multidrug operon emrAB; transcriptional repressor MprA 3602218..3602748 Escherichia coli O157:H7 str. EDL933 958137 NP_289236.1 CDS emrA NC_002655.2 3602875 3604047 D multidrug resistance secretion protein 3602875..3604047 Escherichia coli O157:H7 str. EDL933 958138 NP_289237.1 CDS emrB NC_002655.2 3604064 3605602 D multidrug resistance protein B 3604064..3605602 Escherichia coli O157:H7 str. EDL933 957369 NP_289238.1 CDS ygaG NC_002655.2 3605666 3606181 R catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2; S-ribosylhomocysteinase complement(3605666..3606181) Escherichia coli O157:H7 str. EDL933 960942 NP_289239.1 CDS gshA NC_002655.2 3606331 3607887 R involved in the first step of glutathione biosynthesis; glutamate--cysteine ligase complement(3606331..3607887) Escherichia coli O157:H7 str. EDL933 959286 NP_289240.1 CDS Z3990 NC_002655.2 3607960 3608388 R hypothetical protein complement(3607960..3608388) Escherichia coli O157:H7 str. EDL933 957957 NP_289241.1 CDS yqaB NC_002655.2 3608385 3608951 R YqaB; catalyzes the dephosphorylation of fructose 1-phosphate, 6-phosphogluconate and p-nitrophenyl phosphate (pNPP); presents beta-phosphoglucomutase activity at a lower extent; fructose-1-phosphatase complement(3608385..3608951) Escherichia coli O157:H7 str. EDL933 958139 NP_289242.1 CDS csrA NC_002655.2 3610180 3610365 R affects carbohydrate metabolism; has regulatory role in many processes; carbon storage regulator complement(3610180..3610365) Escherichia coli O157:H7 str. EDL933 956962 NP_289243.1 CDS alaS NC_002655.2 3610595 3613231 R Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase complement(3610595..3613231) Escherichia coli O157:H7 str. EDL933 958243 NP_289244.1 CDS Z4000 NC_002655.2 3612917 3613318 D No significant matches; hypothetical protein 3612917..3613318 Escherichia coli O157:H7 str. EDL933 958152 NP_289245.1 CDS recX NC_002655.2 3613359 3613859 R binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX complement(3613359..3613859) Escherichia coli O157:H7 str. EDL933 956712 NP_289246.1 CDS recA NC_002655.2 3613927 3614988 R catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A complement(3613927..3614988) Escherichia coli O157:H7 str. EDL933 958481 NP_289247.1 CDS ygaD NC_002655.2 3615068 3615565 R competence damage-inducible protein A complement(3615068..3615565) Escherichia coli O157:H7 str. EDL933 958154 NP_289248.1 CDS mltB NC_002655.2 3615710 3616795 R membrane-bound lytic murein transglycosylase B; catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine in peptidoglycan; murein hydrolase B complement(3615710..3616795) Escherichia coli O157:H7 str. EDL933 958155 NP_289249.1 CDS srlA_1 NC_002655.2 3617050 3617445 D PTS system, glucitol/sorbitol-specific IIC component, one of two; frag 3617050..3617445 Escherichia coli O157:H7 str. EDL933 958148 NP_289250.1 CDS srlA_2 NC_002655.2 3617478 3617612 D PTS system, glucitol/sorbitol-specific IIC component, one of two; frag 3617478..3617612 Escherichia coli O157:H7 str. EDL933 958136 NP_289251.1 CDS srlE_1 NC_002655.2 3617609 3617815 D PTS system, glucitol/sorbitol-specific IIB component and second of two IIC components; frag 3617609..3617815 Escherichia coli O157:H7 str. EDL933 958164 NP_289252.1 CDS srlE_2 NC_002655.2 3617920 3618570 D PTS system, glucitol/sorbitol-specific IIB component and second of two IIC components; frag 3617920..3618570 Escherichia coli O157:H7 str. EDL933 958167 NP_289253.1 CDS srlB NC_002655.2 3618581 3618952 D phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system glucitol/sorbitol-specific transporter subunit IIA 3618581..3618952 Escherichia coli O157:H7 str. EDL933 958241 NP_289254.1 CDS srlD NC_002655.2 3618956 3619735 D catalyzes the conversion of sorbitol 6-phosphate into fructose 6-phosphate; sorbitol-6-phosphate dehydrogenase 3618956..3619735 Escherichia coli O157:H7 str. EDL933 957080 NP_289255.1 CDS gutM NC_002655.2 3619841 3620200 D regulator for glucitol utilization; DNA-binding transcriptional activator GutM 3619841..3620200 Escherichia coli O157:H7 str. EDL933 958170 NP_289256.1 CDS srlR NC_002655.2 3620352 3621041 D regulates genes involved in glucitol utilization; DNA-binding transcriptional repressor SrlR 3620352..3621041 Escherichia coli O157:H7 str. EDL933 958179 NP_289257.2 CDS gutQ NC_002655.2 3621034 3621999 D catalyzes the conversion of D-arabinose 5-phosphate to D-ribulose-5-phosphate; D-arabinose 5-phosphate isomerase 3621034..3621999 Escherichia coli O157:H7 str. EDL933 958166 NP_289258.2 CDS ygaA NC_002655.2 3621996 3623510 R Required for the expression of anaerobic nitric oxide (NO) reductase; acts as a transcriptional activator for the norVW operon; anaerobic nitric oxide reductase transcriptional regulator complement(3621996..3623510) Escherichia coli O157:H7 str. EDL933 958171 NP_289259.1 CDS Z4018 NC_002655.2 3623697 3624932 D detoxifies nitric oxide using NADH; anaerobic nitric oxide reductase flavorubredoxin 3623697..3624932 Escherichia coli O157:H7 str. EDL933 958174 NP_289260.1 CDS ygbD NC_002655.2 3624929 3626062 D catalyzes the reduction of the rubredoxin moiety of nitric oxide reductase; nitric oxide reductase 3624929..3626062 Escherichia coli O157:H7 str. EDL933 961331 NP_289261.1 CDS hypF NC_002655.2 3626190 3628442 R transcriptional regulatory protein complement(3626190..3628442) Escherichia coli O157:H7 str. EDL933 957086 NP_289262.1 CDS hydN NC_002655.2 3628595 3629122 R involved in electron transport from formate to hydrogen; electron transport protein HydN complement(3628595..3629122) Escherichia coli O157:H7 str. EDL933 960982 NP_289263.1 CDS ascG NC_002655.2 3629271 3630284 R ascBF operon repressor complement(3629271..3630284) Escherichia coli O157:H7 str. EDL933 958175 NP_289264.1 CDS ascF NC_002655.2 3630541 3631998 D phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system cellobiose/arbutin/salicin-specific transporter subunit IIBC 3630541..3631998 Escherichia coli O157:H7 str. EDL933 958177 NP_289265.1 CDS ascB NC_002655.2 3632007 3633431 D cryptic 6-phospho-beta-glucosidase 3632007..3633431 Escherichia coli O157:H7 str. EDL933 960884 NP_289266.1 CDS hycI NC_002655.2 3633555 3634025 R involved in the C-terminal processing of the large subunit of hydrogenase 3 HycE; hydrogenase 3 maturation protease complement(3633555..3634025) Escherichia coli O157:H7 str. EDL933 959495 NP_289267.1 CDS hycH NC_002655.2 3634018 3634428 R processing of large subunit (HycE) of hydrogenase 3 (part of the FHL complex) complement(3634018..3634428) Escherichia coli O157:H7 str. EDL933 961285 NP_289268.1 CDS hycG NC_002655.2 3634425 3635192 R hydrogenase activity complement(3634425..3635192) Escherichia coli O157:H7 str. EDL933 961295 NP_289269.1 CDS hycF NC_002655.2 3635192 3635734 R electron transfer protein for hydrogenase-3; the formate hydrogenlyase complex comprises of a formate dehydrogenase, unidentified electron carriers and hydrogenase-3; in this non-energy conserving pathway, molecular hydrogen and carbodioxide are released from formate; formate hydrogenlyase complex iron-sulfur subunit complement(3635192..3635734) Escherichia coli O157:H7 str. EDL933 958178 NP_289270.1 CDS hycE NC_002655.2 3635744 3637453 R large subunit of hydrogenase 3 (part of FHL complex) complement(3635744..3637453) Escherichia coli O157:H7 str. EDL933 958180 NP_289271.1 CDS hycD NC_002655.2 3637471 3638394 R membrane-spanning protein of hydrogenase 3 (part of FHL complex) complement(3637471..3638394) Escherichia coli O157:H7 str. EDL933 959323 NP_289272.1 CDS hycC NC_002655.2 3638397 3640223 R catalyzes the oxidation of formate to carbon dioxide and molecular hydrogen; formate hydrogenlyase comprises of a formate dehydrogenase, unidentified electron carriers and a hydrogenase (subunit 3); formate hydrogenlyase subunit 3 complement(3638397..3640223) Escherichia coli O157:H7 str. EDL933 958062 NP_289273.1 CDS hycB NC_002655.2 3640220 3640831 R small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) complement(3640220..3640831) Escherichia coli O157:H7 str. EDL933 958181 NP_289274.1 CDS hycA NC_002655.2 3640956 3641417 R regulates several genes involved in the formate hydrogenlyase system; seems to prevent binding of FhlA transcriptional activator to the activator sequence of hyc operon; formate hydrogenlyase regulatory protein HycA complement(3640956..3641417) Escherichia coli O157:H7 str. EDL933 958172 NP_289275.1 CDS Z4034 NC_002655.2 3641451 3641588 R No significant matches; hypothetical protein complement(3641451..3641588) Escherichia coli O157:H7 str. EDL933 958854 NP_289276.1 CDS hypA NC_002655.2 3641629 3641979 D plays a role in hydrogenase nickel cofactor insertion; hydrogenase nickel incorporation protein 3641629..3641979 Escherichia coli O157:H7 str. EDL933 958185 NP_289277.1 CDS hypB NC_002655.2 3641983 3642855 D GTP hydrolase involved in nickel liganding into hydrogenases; hydrogenase nickel incorporation protein HypB 3641983..3642855 Escherichia coli O157:H7 str. EDL933 958186 NP_289278.1 CDS hypC NC_002655.2 3642846 3643118 D HypC; accessory protein necessary for maturation of the hydrogenase isoforms 1, 2 and 3; forms a complex with HypD, HypE, and HypF proteins, which is the site of ligand biosynthesis and attachment to the iron atom of the NiFe site in the hydrogenase; hydrogenase assembly chaperone 3642846..3643118 Escherichia coli O157:H7 str. EDL933 958189 NP_289279.1 CDS hypD NC_002655.2 3643118 3644239 D pleiotrophic effects on 3 hydrogenase isozymes 3643118..3644239 Escherichia coli O157:H7 str. EDL933 958190 NP_289280.1 CDS hypE NC_002655.2 3644278 3645246 D plays structural role in maturation of all 3 hydrogenase 3644278..3645246 Escherichia coli O157:H7 str. EDL933 959715 NP_289281.1 CDS fhlA NC_002655.2 3645320 3647398 D formate hydrogenlyase transcriptional activator 3645320..3647398 Escherichia coli O157:H7 str. EDL933 959312 NP_289282.1 CDS ygbA NC_002655.2 3647435 3647788 R hypothetical protein complement(3647435..3647788) Escherichia coli O157:H7 str. EDL933 958192 NP_289283.1 CDS Z4042 NC_002655.2 3647865 3647999 R No significant matches; hypothetical protein complement(3647865..3647999) Escherichia coli O157:H7 str. EDL933 958196 NP_289284.1 CDS mutS NC_002655.2 3648075 3650636 D This protein performs the mismatch recognition step during the DNA repair process; DNA mismatch repair protein MutS 3648075..3650636 Escherichia coli O157:H7 str. EDL933 960689 NP_289285.1 CDS pphB NC_002655.2 3650742 3651398 D serine/threonine-specific protein phosphatase 2 3650742..3651398 Escherichia coli O157:H7 str. EDL933 958197 NP_289286.1 CDS Z4045 NC_002655.2 3651439 3651675 R hypothetical protein complement(3651439..3651675) Escherichia coli O157:H7 str. EDL933 958176 NP_289287.1 CDS Z4046 NC_002655.2 3651686 3653113 R hypothetical protein complement(3651686..3653113) Escherichia coli O157:H7 str. EDL933 958198 NP_289288.1 CDS Z4047 NC_002655.2 3653113 3653706 R decarboxylase complement(3653113..3653706) Escherichia coli O157:H7 str. EDL933 958201 NP_289289.1 CDS Z4048 NC_002655.2 3653820 3654260 D regulator 3653820..3654260 Escherichia coli O157:H7 str. EDL933 956807 NP_289290.1 CDS rpoS NC_002655.2 3654380 3655372 R sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor controls a regulon of genes required for protection against external stresses; RNA polymerase sigma factor RpoS complement(3654380..3655372) Escherichia coli O157:H7 str. EDL933 960243 NP_289291.1 CDS nlpD NC_002655.2 3655435 3656574 R outer membrane lipoprotein involved in stationary-phase cell survival; similar to LppB virulence determinant from Haemophilus somnus; lipoprotein NlpD complement(3655435..3656574) Escherichia coli O157:H7 str. EDL933 958191 NP_289292.1 CDS pcm NC_002655.2 3656714 3657340 R catalyzes the methyl esterification of L-isoaspartyl residues that are formed in damaged proteins; protein-L-isoaspartate O-methyltransferase complement(3656714..3657340) Escherichia coli O157:H7 str. EDL933 958203 NP_289293.1 CDS surE NC_002655.2 3657334 3658095 R catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate; stationary phase survival protein SurE complement(3657334..3658095) Escherichia coli O157:H7 str. EDL933 958038 NP_289294.1 CDS truD NC_002655.2 3658076 3659125 R catalyzes the modification of U13 in tRNA(Glu); tRNA pseudouridine synthase D complement(3658076..3659125) Escherichia coli O157:H7 str. EDL933 959812 NP_289295.1 CDS ispF NC_002655.2 3659122 3659601 R catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase complement(3659122..3659601) Escherichia coli O157:H7 str. EDL933 958205 NP_289296.1 CDS ispD NC_002655.2 3659601 3660311 R 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase complement(3659601..3660311) Escherichia coli O157:H7 str. EDL933 958207 NP_289297.1 CDS ftsB NC_002655.2 3660330 3660641 R forms a complex with FtsL and FtsQ; colocalizes to the septal region of the dividing cell; membrane protein; cell division protein FtsB complement(3660330..3660641) Escherichia coli O157:H7 str. EDL933 958045 NP_289298.1 CDS ygbE NC_002655.2 3660835 3661158 R hypothetical protein complement(3660835..3661158) Escherichia coli O157:H7 str. EDL933 957011 NP_289299.1 CDS cysC NC_002655.2 3661208 3661813 R converts ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis; adenylylsulfate kinase complement(3661208..3661813) Escherichia coli O157:H7 str. EDL933 957346 NP_289300.1 CDS cysN NC_002655.2 3661813 3663240 R may be GTPase that regulates ATP sulfurylase activity that is involved in converting ATP and sulfate to diphosphate and adenylylsulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis in the first step; forms a heterodimer with CysD; part of the GTP-binding elongation factor family CysN/NodQ; sulfate adenylyltransferase subunit 1 complement(3661813..3663240) Escherichia coli O157:H7 str. EDL933 958208 NP_289301.1 CDS cysD NC_002655.2 3663242 3664150 R with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP; sulfate adenylyltransferase subunit 2 complement(3663242..3664150) Escherichia coli O157:H7 str. EDL933 958209 NP_289302.1 CDS iap NC_002655.2 3664402 3665439 D catalyzes the sequential removal of 2 amino-terminal arginines from alkaline phosphatase isozyme 1 to form isozymes 2 and 3; alkaline phosphatase 3664402..3665439 Escherichia coli O157:H7 str. EDL933 959560 NP_289303.1 CDS ygbF NC_002655.2 3665829 3666122 R hypothetical protein complement(3665829..3666122) Escherichia coli O157:H7 str. EDL933 960428 NP_289304.1 CDS Z4064 NC_002655.2 3666119 3667042 R hypothetical protein complement(3666119..3667042) Escherichia coli O157:H7 str. EDL933 960422 NP_289305.1 CDS Z4065 NC_002655.2 3667039 3667689 R hypothetical protein complement(3667039..3667689) Escherichia coli O157:H7 str. EDL933 958213 NP_289306.1 CDS Z4066 NC_002655.2 3667671 3668417 R hypothetical protein complement(3667671..3668417) Escherichia coli O157:H7 str. EDL933 958216 NP_289307.1 CDS Z4067 NC_002655.2 3668428 3669483 R hypothetical protein complement(3668428..3669483) Escherichia coli O157:H7 str. EDL933 958217 NP_289308.1 CDS Z4068 NC_002655.2 3669495 3670031 R No significant matches; hypothetical protein complement(3669495..3670031) Escherichia coli O157:H7 str. EDL933 959305 NP_289309.1 CDS Z4069 NC_002655.2 3670028 3671590 R hypothetical protein complement(3670028..3671590) Escherichia coli O157:H7 str. EDL933 959497 NP_289310.1 CDS ygcB NC_002655.2 3671688 3674387 R hypothetical protein complement(3671688..3674387) Escherichia coli O157:H7 str. EDL933 958379 NP_289311.1 CDS Z4071 NC_002655.2 3674579 3674731 R hypothetical protein complement(3674579..3674731) Escherichia coli O157:H7 str. EDL933 958220 NP_289312.1 CDS cysH NC_002655.2 3674995 3675729 R catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite; phosphoadenosine phosphosulfate reductase complement(3674995..3675729) Escherichia coli O157:H7 str. EDL933 958221 NP_289313.1 CDS cysI NC_002655.2 3675803 3677515 R hemoprotein; NADPH dependent; with the alpha subunit (a flavoprotein) catalyzes the reduction of sulfite to sulfide; sulfite reductase subunit beta complement(3675803..3677515) Escherichia coli O157:H7 str. EDL933 959281 NP_289314.1 CDS cysJ NC_002655.2 3677515 3679314 R catalyzes the reduction of sulfite to sulfide in the biosynthesis of L-cysteine from sulfate; a flavoprotein with flavin reductase activity; sulfite reductase subunit alpha complement(3677515..3679314) Escherichia coli O157:H7 str. EDL933 959221 NP_289315.1 CDS ygcM NC_002655.2 3679630 3679995 D 6-pyruvoyl tetrahydrobiopterin synthase 3679630..3679995 Escherichia coli O157:H7 str. EDL933 961174 NP_289316.1 CDS ygcN NC_002655.2 3680043 3681344 D hypothetical protein 3680043..3681344 Escherichia coli O157:H7 str. EDL933 958222 NP_289317.1 CDS Z4077 NC_002655.2 3681299 3681595 D hypothetical protein 3681299..3681595 Escherichia coli O157:H7 str. EDL933 957041 NP_289318.1 CDS ygcP NC_002655.2 3681612 3682187 D anti-terminator regulatory protein 3681612..3682187 Escherichia coli O157:H7 str. EDL933 958115 NP_289319.1 CDS Z4079 NC_002655.2 3682335 3682610 R hypothetical protein complement(3682335..3682610) Escherichia coli O157:H7 str. EDL933 958228 NP_289320.1 CDS Z4080 NC_002655.2 3682626 3683195 R hypothetical protein complement(3682626..3683195) Escherichia coli O157:H7 str. EDL933 958229 NP_289321.1 CDS ygcR NC_002655.2 3683192 3683977 R transporter complement(3683192..3683977) Escherichia coli O157:H7 str. EDL933 958230 NP_289322.1 CDS Z4083m NC_002655.2 3683949 3685357 R major facilitator superfamily permease complement(join(3683949..3684266,3684266..3685357)) Escherichia coli O157:H7 str. EDL933 959643 NP_289323.1 CDS Z4084 NC_002655.2 3685379 3686173 R alkyl-dihydroxyacetonephosphate synthase complement(3685379..3686173) Escherichia coli O157:H7 str. EDL933 958231 NP_289324.1 CDS ygcW NC_002655.2 3686903 3687763 R oxidoreductase complement(3686903..3687763) Escherichia coli O157:H7 str. EDL933 958234 NP_289325.1 CDS yqcE NC_002655.2 3688007 3689284 D transporter 3688007..3689284 Escherichia coli O157:H7 str. EDL933 958235 NP_289326.1 CDS ygcE NC_002655.2 3689311 3690789 D kinase 3689311..3690789 Escherichia coli O157:H7 str. EDL933 958236 NP_289328.1 CDS ygcF NC_002655.2 3691853 3692524 R hypothetical protein complement(3691853..3692524) Escherichia coli O157:H7 str. EDL933 958233 NP_289329.1 CDS Z4090 NC_002655.2 3692805 3693299 D hypothetical protein 3692805..3693299 Escherichia coli O157:H7 str. EDL933 958240 NP_289330.1 CDS Z4091 NC_002655.2 3693289 3693987 D hypothetical protein 3693289..3693987 Escherichia coli O157:H7 str. EDL933 958239 NP_289331.1 CDS Z4092 NC_002655.2 3694221 3695369 D hypothetical protein 3694221..3695369 Escherichia coli O157:H7 str. EDL933 959390 NP_289332.1 CDS Z4093 NC_002655.2 3695375 3696280 D hypothetical protein 3695375..3696280 Escherichia coli O157:H7 str. EDL933 958242 NP_289333.1 CDS eno NC_002655.2 3696340 3697638 R enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase complement(3696340..3697638) Escherichia coli O157:H7 str. EDL933 958245 NP_289334.1 CDS pyrG NC_002655.2 3697726 3699363 R CTP synthase; CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase complement(3697726..3699363) Escherichia coli O157:H7 str. EDL933 958246 NP_289335.1 CDS mazG NC_002655.2 3699591 3700382 R functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase Era; nucleoside triphosphate pyrophosphohydrolase complement(3699591..3700382) Escherichia coli O157:H7 str. EDL933 958247 NP_289336.1 CDS chpA NC_002655.2 3700453 3700788 R MazF; endoribonuclease; toxin of the ChpA-ChpR toxin-antitoxin system; toxin ChpA complement(3700453..3700788) Escherichia coli O157:H7 str. EDL933 958248 NP_289337.1 CDS chpR NC_002655.2 3700788 3701036 R part of the MazF-MazE toxin-antitoxin system; conteracts MazF; antitoxin MazE complement(3700788..3701036) Escherichia coli O157:H7 str. EDL933 958252 NP_289338.1 CDS relA NC_002655.2 3701114 3703348 R (p)ppGpp synthetase; catalyzes the formation of pppGpp and ppGpp from ATP and GTP or GDP; GDP/GTP pyrophosphokinase complement(3701114..3703348) Escherichia coli O157:H7 str. EDL933 958253 NP_289339.1 CDS rumA NC_002655.2 3703396 3704697 R in Escherichia coli this enzyme catalyzes the SAM-dependent methylation of U1939 in the 23S ribomal RNA; binds an iron-sulfur cluster [4Fe-4S]; 23S rRNA 5-methyluridine methyltransferase complement(3703396..3704697) Escherichia coli O157:H7 str. EDL933 958250 NP_289340.1 CDS barA NC_002655.2 3704754 3707510 D part of the two-component regulatory system with UvrY; involved in the regulation of carbon metabolism via the csrA/csrB regulatory system; hybrid sensory histidine kinase BarA 3704754..3707510 Escherichia coli O157:H7 str. EDL933 958008 NP_289341.1 CDS ygcX NC_002655.2 3707743 3709083 R glucarate dehydratase complement(3707743..3709083) Escherichia coli O157:H7 str. EDL933 958251 NP_289342.1 CDS ygcY NC_002655.2 3709104 3710201 R glucarate dehydratase complement(3709104..3710201) Escherichia coli O157:H7 str. EDL933 958256 NP_289343.1 CDS Z4104 NC_002655.2 3710223 3710444 R hypothetical protein complement(3710223..3710444) Escherichia coli O157:H7 str. EDL933 958257 NP_289344.1 CDS Z4105 NC_002655.2 3710446 3711798 R transporter complement(3710446..3711798) Escherichia coli O157:H7 str. EDL933 958258 NP_289345.1 CDS Z4106 NC_002655.2 3712233 3712682 R An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin complement(3712233..3712682) Escherichia coli O157:H7 str. EDL933 958259 NP_289346.1 CDS Z4107 NC_002655.2 3712700 3713482 R catalyzes formation of pseudouridine at position 65 in tRNA-Ile1 and tRNA-Asp; tRNA pseudouridine synthase C complement(3712700..3713482) Escherichia coli O157:H7 str. EDL933 957078 NP_289347.1 CDS Z4108 NC_002655.2 3713482 3713811 R hypothetical protein complement(3713482..3713811) Escherichia coli O157:H7 str. EDL933 958307 NP_289348.1 CDS syd NC_002655.2 3714433 3714978 R SecY regulator that either chelates excess SecY or negatively regulates the SecYE translocase function; SecY interacting protein Syd complement(3714433..3714978) Escherichia coli O157:H7 str. EDL933 958261 NP_289349.1 CDS queF NC_002655.2 3715046 3715894 D catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis; 7-cyano-7-deazaguanine reductase 3715046..3715894 Escherichia coli O157:H7 str. EDL933 956767 NP_289350.1 CDS ygdH NC_002655.2 3716006 3717370 D hypothetical protein 3716006..3717370 Escherichia coli O157:H7 str. EDL933 958262 NP_289351.1 CDS sdaC NC_002655.2 3717927 3719216 D serine transporter 3717927..3719216 Escherichia coli O157:H7 str. EDL933 958263 NP_289352.1 CDS sdaB NC_002655.2 3719274 3720641 D L-serine dehydratase 3719274..3720641 Escherichia coli O157:H7 str. EDL933 958265 NP_289353.1 CDS xni NC_002655.2 3720663 3721508 D has 3'-5' exonuclease activity that preferentially acts on ssDNA; also 3'-phosphodiesterase activity at sites with 3' incised apurinic/apyrimidinic sites; can remove 3' phosphoglycolate groups; exonuclease IX 3720663..3721508 Escherichia coli O157:H7 str. EDL933 958266 NP_289354.1 CDS fucO NC_002655.2 3721563 3722714 R L-1,2-propanediol oxidoreductase complement(3721563..3722714) Escherichia coli O157:H7 str. EDL933 958299 NP_289355.1 CDS fucA NC_002655.2 3722739 3723386 R catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate; L-fuculose phosphate aldolase complement(3722739..3723386) Escherichia coli O157:H7 str. EDL933 958302 NP_289356.1 CDS fucP NC_002655.2 3723933 3725249 D L-fucose transporter 3723933..3725249 Escherichia coli O157:H7 str. EDL933 957232 NP_289357.1 CDS fucI NC_002655.2 3725282 3727057 D catalyzes the conversion of the aldose L-fucose into the corresponding ketose L-fuculose; L-fucose isomerase 3725282..3727057 Escherichia coli O157:H7 str. EDL933 958301 NP_289358.1 CDS fucK NC_002655.2 3727136 3728584 D L-fuculokinase 3727136..3728584 Escherichia coli O157:H7 str. EDL933 958268 NP_289359.1 CDS fucU NC_002655.2 3728586 3729008 D protein of fucose operon 3728586..3729008 Escherichia coli O157:H7 str. EDL933 958270 NP_289360.1 CDS fucR NC_002655.2 3729066 3729797 D regulates expression of genes involved in L-fucose utilization; DNA-binding transcriptional activator FucR 3729066..3729797 Escherichia coli O157:H7 str. EDL933 958272 NP_289361.1 CDS ygdE NC_002655.2 3729841 3730941 R RNA 2'-O-ribose methyltransferase complement(3729841..3730941) Escherichia coli O157:H7 str. EDL933 958273 NP_289362.1 CDS ygdD NC_002655.2 3730934 3731329 R hypothetical protein complement(3730934..3731329) Escherichia coli O157:H7 str. EDL933 958274 NP_289363.1 CDS gcvA NC_002655.2 3731348 3732265 R Glycine cleavage system transcriptional activator; activates the gcvTHP operon in the presence of glycine and represses the operon in its absence; DNA-binding transcriptional activator GcvA complement(3731348..3732265) Escherichia coli O157:H7 str. EDL933 958267 NP_289364.1 CDS Z4126 NC_002655.2 3732616 3732846 R hypothetical protein complement(3732616..3732846) Escherichia coli O157:H7 str. EDL933 958947 NP_289365.1 CDS Z4127 NC_002655.2 3733035 3734240 D cysteine sulfinate desulfinase 3733035..3734240 Escherichia coli O157:H7 str. EDL933 956864 NP_289366.1 CDS ygdK NC_002655.2 3734240 3734683 D hypothetical protein 3734240..3734683 Escherichia coli O157:H7 str. EDL933 958277 NP_289367.1 CDS ygdL NC_002655.2 3734734 3735540 R hypothetical protein complement(3734734..3735540) Escherichia coli O157:H7 str. EDL933 958278 NP_289368.1 CDS mltA NC_002655.2 3735779 3736876 R membrane-bound, lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; murein transglycosylase A complement(3735779..3736876) Escherichia coli O157:H7 str. EDL933 958279 NP_289369.1 CDS Z4134 NC_002655.2 3737455 3738798 R amidase complement(3737455..3738798) Escherichia coli O157:H7 str. EDL933 959411 NP_289370.1 CDS argA NC_002655.2 3738940 3740271 D catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis; N-acetylglutamate synthase 3738940..3740271 Escherichia coli O157:H7 str. EDL933 957960 NP_289371.1 CDS recD NC_002655.2 3740333 3742159 R helicase/nuclease; with RecBC catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity; exonuclease V subunit alpha complement(3740333..3742159) Escherichia coli O157:H7 str. EDL933 958288 NP_289372.1 CDS recB NC_002655.2 3742159 3745701 R helicase/nuclease; with RecCD catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity; exonuclease V subunit beta complement(3742159..3745701) Escherichia coli O157:H7 str. EDL933 958289 NP_289373.1 CDS ptr NC_002655.2 3745694 3748582 R protease III complement(3745694..3748582) Escherichia coli O157:H7 str. EDL933 958290 NP_289374.1 CDS recC NC_002655.2 3748758 3752126 R catalyzes ATP-dependent exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides; component of the RecBCD (Exo V) helicase/nuclease complex that is essential for recombination; exonuclease V subunit gamma complement(3748758..3752126) Escherichia coli O157:H7 str. EDL933 958276 NP_289375.1 CDS ppdC NC_002655.2 3752139 3752462 R hypothetical protein complement(3752139..3752462) Escherichia coli O157:H7 str. EDL933 958296 NP_289376.2 CDS ygdB NC_002655.2 3752447 3752854 R hypothetical protein complement(3752447..3752854) Escherichia coli O157:H7 str. EDL933 958291 NP_289377.1 CDS ppdB NC_002655.2 3752851 3753414 R hypothetical protein complement(3752851..3753414) Escherichia coli O157:H7 str. EDL933 961190 NP_289378.1 CDS ppdA NC_002655.2 3753405 3753875 R hypothetical protein complement(3753405..3753875) Escherichia coli O157:H7 str. EDL933 958545 NP_289379.1 CDS thyA NC_002655.2 3754059 3754853 R ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase complement(3754059..3754853) Escherichia coli O157:H7 str. EDL933 959426 NP_289380.1 CDS lgt NC_002655.2 3754860 3755735 R transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase complement(3754860..3755735) Escherichia coli O157:H7 str. EDL933 958292 NP_289381.1 CDS ptsP NC_002655.2 3755886 3758132 R member of a second PTS chain involved in nitrogen metabolism; PtsP phosphorylates NPr; fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain complement(3755886..3758132) Escherichia coli O157:H7 str. EDL933 958294 NP_289382.1 CDS ygdP NC_002655.2 3758145 3758675 R hydrolyzes diadenosine polyphosphate; dinucleoside polyphosphate hydrolase complement(3758145..3758675) Escherichia coli O157:H7 str. EDL933 958297 NP_289383.1 CDS Z4148 NC_002655.2 3759028 3759174 R No significant matches; hypothetical protein complement(3759028..3759174) Escherichia coli O157:H7 str. EDL933 958298 NP_289384.1 CDS mutH NC_002655.2 3759360 3760049 D MutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences during DNA repair; DNA mismatch repair protein 3759360..3760049 Escherichia coli O157:H7 str. EDL933 958300 NP_289385.1 CDS Z4150 NC_002655.2 3760118 3760831 D transporter 3760118..3760831 Escherichia coli O157:H7 str. EDL933 958303 NP_289386.1 CDS Z4151 NC_002655.2 3760969 3761187 D hypothetical protein 3760969..3761187 Escherichia coli O157:H7 str. EDL933 958295 NP_289387.1 CDS tas NC_002655.2 3761295 3762335 D complements the prephenate dehydrogenase dysfunction of an Escherichia coli tyrosine auxotroph strain; member of the aldo/keto reductase 2 family; crystal structure of purified Escherichia coli protein shows bound NADPH; aldo/keto reductase 3761295..3762335 Escherichia coli O157:H7 str. EDL933 958310 NP_289388.1 CDS ygeD NC_002655.2 3762367 3763560 R lysophospholipid transporter LplT complement(3762367..3763560) Escherichia coli O157:H7 str. EDL933 957841 NP_289389.1 CDS aas NC_002655.2 3763553 3765712 R Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1; bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase complement(3763553..3765712) Escherichia coli O157:H7 str. EDL933 958304 NP_289390.1 CDS galR NC_002655.2 3766299 3767330 D controls transcription of galETKM; DNA-binding transcriptional regulator GalR 3766299..3767330 Escherichia coli O157:H7 str. EDL933 958305 NP_289391.1 CDS lysA NC_002655.2 3767337 3768599 R catalyzes the decarboxylation of diaminopimelate into lysine; pyridoxal phosphate(PLP)-binding; diaminopimelate decarboxylase complement(3767337..3768599) Escherichia coli O157:H7 str. EDL933 958308 NP_289392.1 CDS lysR NC_002655.2 3768721 3769656 D activates the transcription of the lysA gene encoding diaminopimelate decarboxylase; LysR family transcriptional regulator 3768721..3769656 Escherichia coli O157:H7 str. EDL933 958309 NP_289393.1 CDS ygeA NC_002655.2 3769643 3770335 R racemase complement(3769643..3770335) Escherichia coli O157:H7 str. EDL933 959363 NP_289394.1 CDS araE NC_002655.2 3770464 3771882 R low-affinity L-arabinose transport system proton symport protein complement(3770464..3771882) Escherichia coli O157:H7 str. EDL933 958165 NP_289395.1 CDS kduD NC_002655.2 3772197 3772958 R catalyzes the formation of 3-dehydro-2-deoxy-D-gluconate from 2-deoxy-D-gluconate; 2-deoxy-D-gluconate 3-dehydrogenase complement(3772197..3772958) Escherichia coli O157:H7 str. EDL933 959349 NP_289396.1 CDS kduI NC_002655.2 3772988 3773824 R 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase; catalyzes the interconversion of 4-deoxy-L-threo-5-hexosulose uronate to 3-deoxy-D-glycero-2,5-hexodiulosonate; 5-keto-4-deoxyuronate isomerase complement(3772988..3773824) Escherichia coli O157:H7 str. EDL933 958313 NP_289397.2 CDS yqeF NC_002655.2 3774111 3775292 R Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis; acetyl-CoA acetyltransferase complement(3774111..3775292) Escherichia coli O157:H7 str. EDL933 958314 NP_289398.1 CDS Z4165 NC_002655.2 3775547 3776776 D transporter protein 3775547..3776776 Escherichia coli O157:H7 str. EDL933 958315 NP_289399.1 CDS yqeH NC_002655.2 3777176 3777868 D hypothetical protein 3777176..3777868 Escherichia coli O157:H7 str. EDL933 956916 NP_289400.1 CDS yqeI NC_002655.2 3778202 3779011 D sensory transducer 3778202..3779011 Escherichia coli O157:H7 str. EDL933 957233 NP_289401.1 CDS yqeJ NC_002655.2 3779095 3779487 D hypothetical protein 3779095..3779487 Escherichia coli O157:H7 str. EDL933 958999 NP_289402.1 CDS yqeK NC_002655.2 3779636 3780073 R hypothetical protein complement(3779636..3780073) Escherichia coli O157:H7 str. EDL933 958318 NP_289403.1 CDS Z4170 NC_002655.2 3780201 3780437 R No significant matches; hypothetical protein complement(3780201..3780437) Escherichia coli O157:H7 str. EDL933 958517 NP_289404.1 CDS Z4171 NC_002655.2 3780491 3780982 D hypothetical protein 3780491..3780982 Escherichia coli O157:H7 str. EDL933 958503 NP_289405.1 CDS ygeG NC_002655.2 3781208 3781699 D hypothetical protein 3781208..3781699 Escherichia coli O157:H7 str. EDL933 958319 NP_289406.1 CDS ygeH NC_002655.2 3782034 3783410 D transcriptional regulator 3782034..3783410 Escherichia coli O157:H7 str. EDL933 958321 NP_289407.1 CDS Z4174 NC_002655.2 3783577 3783795 D hypothetical protein 3783577..3783795 Escherichia coli O157:H7 str. EDL933 958322 NP_289408.1 CDS Z4175 NC_002655.2 3783880 3784383 D hypothetical protein 3783880..3784383 Escherichia coli O157:H7 str. EDL933 958323 NP_289409.1 CDS Z4176 NC_002655.2 3784402 3784848 R 2-component transcriptional regulator complement(3784402..3784848) Escherichia coli O157:H7 str. EDL933 958324 NP_289410.1 CDS Z4177 NC_002655.2 3785201 3785335 D No significant matches; hypothetical protein 3785201..3785335 Escherichia coli O157:H7 str. EDL933 959541 NP_289411.1 CDS Z4178 NC_002655.2 3785257 3785688 R hypothetical protein complement(3785257..3785688) Escherichia coli O157:H7 str. EDL933 958135 NP_289412.1 CDS Z4179 NC_002655.2 3785705 3785965 R hypothetical protein complement(3785705..3785965) Escherichia coli O157:H7 str. EDL933 958326 NP_289413.1 CDS Z4180 NC_002655.2 3786504 3787238 R lipoprotein of type III secretion apparatus complement(3786504..3787238) Escherichia coli O157:H7 str. EDL933 961173 NP_289414.1 CDS Z4181 NC_002655.2 3787235 3787567 R Type III secretion apparatus protein complement(3787235..3787567) Escherichia coli O157:H7 str. EDL933 957709 NP_289415.1 CDS Z4182 NC_002655.2 3787866 3788654 R hypothetical protein complement(3787866..3788654) Escherichia coli O157:H7 str. EDL933 959507 NP_289416.1 CDS Z4183 NC_002655.2 3788951 3789034 R No significant matches; hypothetical protein complement(3788951..3789034) Escherichia coli O157:H7 str. EDL933 958330 NP_289417.1 CDS Z4184 NC_002655.2 3789283 3789783 D No significant matches; hypothetical protein 3789283..3789783 Escherichia coli O157:H7 str. EDL933 956948 NP_289418.1 CDS Z4185 NC_002655.2 3790140 3791261 R Required for surface presentation of invasion plasmid antigens; required for invasion and for secretion of the three ipa proteins; surface presentation of antigens protein SpaS complement(3790140..3791261) Escherichia coli O157:H7 str. EDL933 957768 NP_289419.1 CDS Z4186 NC_002655.2 3791270 3791506 R integral membrane protein-component of typeIII secretion apparatus complement(3791270..3791506) Escherichia coli O157:H7 str. EDL933 958328 NP_289420.1 CDS Z4187 NC_002655.2 3791585 3792037 R type III secretion apparatus protein complement(3791585..3792037) Escherichia coli O157:H7 str. EDL933 958332 NP_289421.1 CDS Z4188 NC_002655.2 3792039 3792299 R type III secretion apparatus protein complement(3792039..3792299) Escherichia coli O157:H7 str. EDL933 958333 NP_289422.1 CDS spaP NC_002655.2 3792310 3792975 R part of a type III secretory system probably involved in invasion into eukaryotic cells; surface presentation of antigens protein SpaP complement(3792310..3792975) Escherichia coli O157:H7 str. EDL933 958334 NP_289423.1 CDS Z4190 NC_002655.2 3792965 3793951 R involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells; surface presentation of antigens protein SpaO complement(3792965..3793951) Escherichia coli O157:H7 str. EDL933 958331 NP_289424.1 CDS Z4191 NC_002655.2 3793911 3794480 R type III secretion apparatus protein complement(3793911..3794480) Escherichia coli O157:H7 str. EDL933 958336 NP_289425.1 CDS Z4192 NC_002655.2 3794553 3794786 R No significant matches; hypothetical protein complement(3794553..3794786) Escherichia coli O157:H7 str. EDL933 957826 NP_289426.1 CDS Z4193 NC_002655.2 3794764 3795099 R type III secretion apparatus protein complement(3794764..3795099) Escherichia coli O157:H7 str. EDL933 961154 NP_289427.1 CDS Z4194 NC_002655.2 3795212 3796531 R Invasion protein InvC; necessary for efficient entry of S.typhimurium into cultured epithelial cells. Probable catalytic subunit of a protein translocase; ATP synthase SpaL complement(3795212..3796531) Escherichia coli O157:H7 str. EDL933 957284 NP_289428.1 CDS Z4195 NC_002655.2 3796536 3798596 R type III secretion apparatus protein complement(3796536..3798596) Escherichia coli O157:H7 str. EDL933 958340 NP_289429.1 CDS Z4196 NC_002655.2 3798589 3799734 R hypothetical protein complement(3798589..3799734) Escherichia coli O157:H7 str. EDL933 958345 NP_289430.1 CDS Z4197 NC_002655.2 3799739 3801442 R type III secretion apparatus protein complement(3799739..3801442) Escherichia coli O157:H7 str. EDL933 958346 NP_289431.1 CDS Z4198 NC_002655.2 3801439 3802188 R regulatory protein for type III secretion apparatus complement(3801439..3802188) Escherichia coli O157:H7 str. EDL933 958342 NP_289432.1 CDS Z4199 NC_002655.2 3802534 3802713 R No significant matches; hypothetical protein complement(3802534..3802713) Escherichia coli O157:H7 str. EDL933 958337 NP_289433.1 CDS Z4200 NC_002655.2 3802780 3803808 R hypothetical protein complement(3802780..3803808) Escherichia coli O157:H7 str. EDL933 958343 NP_289434.1 CDS Z4201 NC_002655.2 3803822 3804427 R hypothetical protein complement(3803822..3804427) Escherichia coli O157:H7 str. EDL933 958344 NP_289435.1 CDS Z4203 NC_002655.2 3804817 3805488 R lipoprotein complement(3804817..3805488) Escherichia coli O157:H7 str. EDL933 958227 NP_289436.1 CDS Z4205 NC_002655.2 3805982 3808240 D molybdenum cofactor-binding protein; participates in purine salvage; xanthine dehydrogenase subunit XdhA 3805982..3808240 Escherichia coli O157:H7 str. EDL933 958353 NP_289437.2 CDS ygeT NC_002655.2 3808251 3809129 D FAD-binding subunit; with XdhA and XdhC participates in purine salvage; xanthine dehydrogenase subunit XdhB 3808251..3809129 Escherichia coli O157:H7 str. EDL933 958358 NP_289438.1 CDS Z4207 NC_002655.2 3809126 3809605 D iron-sulfur-binding subunit; with XdhA and XdhB participates in purine salvage; xanthine dehydrogenase subunit XdhC 3809126..3809605 Escherichia coli O157:H7 str. EDL933 959352 NP_289439.1 CDS ygeV NC_002655.2 3809645 3811423 R transcriptional regulator complement(3809645..3811423) Escherichia coli O157:H7 str. EDL933 958354 NP_289440.1 CDS Z4209 NC_002655.2 3811899 3813089 D catalyzes the formation of L-citruline from L-ornithine and carbamoylphosphate; aspartate/ornithine carbamoyltransferase 3811899..3813089 Escherichia coli O157:H7 str. EDL933 958325 NP_289441.1 CDS ygeX NC_002655.2 3813147 3814343 D catalyzes the formation of pyruvate from 2,3-diaminopropionate; diaminopropionate ammonia-lyase 3813147..3814343 Escherichia coli O157:H7 str. EDL933 958311 NP_289442.1 CDS ygeY NC_002655.2 3814401 3815612 D Zn-dependent extracellular dipeptidase; similar to succinyl-diaminopimelate desuccinylases; peptidase 3814401..3815612 Escherichia coli O157:H7 str. EDL933 958286 NP_289443.2 CDS Z4212 NC_002655.2 3815665 3817050 D catalyzes the hydrolytic cleavage of hydantoin with aromatic side chains at the 5'position; phenylhydantoinase 3815665..3817050 Escherichia coli O157:H7 str. EDL933 958355 NP_289444.1 CDS yqeA NC_002655.2 3817098 3818030 D catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP; carbamate kinase 3817098..3818030 Escherichia coli O157:H7 str. EDL933 958359 NP_289445.1 CDS Z4214 NC_002655.2 3818071 3819696 R synthase complement(3818071..3819696) Escherichia coli O157:H7 str. EDL933 958244 NP_289446.1 CDS Z4215 NC_002655.2 3819744 3820451 R hypothetical protein complement(3819744..3820451) Escherichia coli O157:H7 str. EDL933 958356 NP_289447.1 CDS ygfJ NC_002655.2 3820617 3821195 D hypothetical protein 3820617..3821195 Escherichia coli O157:H7 str. EDL933 958360 NP_289448.1 CDS Z4217 NC_002655.2 3821519 3824617 D with YgfM and YgfN forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; YgfK mutants are unable to reduce selenate; involved in purine salvage process; seems to act as an oxidoreductase, but sequence similarity suggests it is a dihydrothymine dehydrogenase; selenate reductase subunit YgfK 3821519..3824617 Escherichia coli O157:H7 str. EDL933 958362 NP_289449.2 CDS Z4218 NC_002655.2 3824620 3825948 D in Escherichia coli expression is induced in response to phase-specific signals and controlled by RpoS; chlorohydrolase/aminohydrolase 3824620..3825948 Escherichia coli O157:H7 str. EDL933 958364 NP_289450.1 CDS Z4219 NC_002655.2 3825998 3826777 D with YgfK and YgfN forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; YgfM contains a FAD domain; selenate reductase subunit YgfM 3825998..3826777 Escherichia coli O157:H7 str. EDL933 958366 NP_289451.1 CDS Z4220 NC_002655.2 3826774 3829644 D with YgfK and YgfM forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; molybdopterin-containing enzyme; oxidase activity toward hypoxanthine and xanthine can be detected if these substrates are present at high concentration; selenate reductase subunit YgfN 3826774..3829644 Escherichia coli O157:H7 str. EDL933 958859 NP_289452.1 CDS ygfO NC_002655.2 3829752 3831209 D transporter 3829752..3831209 Escherichia coli O157:H7 str. EDL933 960724 NP_289453.1 CDS ygfP NC_002655.2 3831224 3832543 D Catalyzes the deamination of guanine; guanine deaminase 3831224..3832543 Escherichia coli O157:H7 str. EDL933 958367 NP_289454.1 CDS Z4223 NC_002655.2 3832579 3833946 D hypothetical protein 3832579..3833946 Escherichia coli O157:H7 str. EDL933 958369 NP_289455.1 CDS ygfS NC_002655.2 3833982 3834377 R oxidoreductase, Fe-S subunit complement(3833982..3834377) Escherichia coli O157:H7 str. EDL933 958373 NP_289456.1 CDS ygfT NC_002655.2 3834470 3836404 R unknown function; in E. coli the aegA gene is regulated by Fnr, NarXL, and NarQ (but not ArcA), induced under anaerobic conditions and repressed in the presence of nitrate (anaerobic); oxidoreductase Fe-S binding subunit complement(3834470..3836404) Escherichia coli O157:H7 str. EDL933 958357 NP_289457.1 CDS ygfU NC_002655.2 3836756 3838273 D permease 3836756..3838273 Escherichia coli O157:H7 str. EDL933 958368 NP_289458.1 CDS Z4227 NC_002655.2 3838523 3839071 D catalyzes the rearrangement of isopentenyl diphosphate to dimethylallyl phosphate; isopentenyl-diphosphate delta-isomerase 3838523..3839071 Escherichia coli O157:H7 str. EDL933 957290 NP_289459.1 CDS lysS NC_002655.2 3839114 3840631 R class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase complement(3839114..3840631) Escherichia coli O157:H7 str. EDL933 958385 NP_289460.1 CDS prfB NC_002655.2 3840641 3841739 R recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1; peptide chain release factor 2 complement(join(3840641..3841663,3841665..3841739)) Escherichia coli O157:H7 str. EDL933 958370 NP_289461.1 CDS recJ NC_002655.2 3841830 3843563 R 5'-3' single-stranded-DNA-specific exonuclease; ssDNA exonuclease RecJ complement(3841830..3843563) Escherichia coli O157:H7 str. EDL933 958389 NP_289462.1 CDS dsbC NC_002655.2 3843569 3844279 R DsbC; periplasmic protein with protein disulfide isomerase activity; this protein also shows disulfide oxidoreductase activity; thiol:disulfide interchange protein DsbC complement(3843569..3844279) Escherichia coli O157:H7 str. EDL933 958374 NP_289463.1 CDS xerD NC_002655.2 3844304 3845200 R site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD complement(3844304..3845200) Escherichia coli O157:H7 str. EDL933 958371 NP_289464.1 CDS fldB NC_002655.2 3845312 3845833 D An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic; flavodoxin FldB 3845312..3845833 Escherichia coli O157:H7 str. EDL933 958365 NP_289465.1 CDS Z4234 NC_002655.2 3845873 3846280 R hypothetical protein complement(3845873..3846280) Escherichia coli O157:H7 str. EDL933 958376 NP_289466.1 CDS ygfY NC_002655.2 3846261 3846527 R hypothetical protein complement(3846261..3846527) Escherichia coli O157:H7 str. EDL933 958377 NP_289467.1 CDS ygfZ NC_002655.2 3846770 3847750 D physiological role is not clear; not essential for growth but mutants grow poorly; mutations suppress hda null mutations; may be involved in regulation of ATP-DnaA levels; may also be involved in regulation of tRNA modifications; can bind folic acid and tetrahydrofolate; forms a three domain ring-like structure with a central channel; structurally similar to DMGO protein from A. globiformis; shows sequence similarity to yeast CAF17 transcriptional regulator; global regulator 3846770..3847750 Escherichia coli O157:H7 str. EDL933 958375 NP_289468.1 CDS Z4237 NC_002655.2 3847827 3848486 R oxidoreductase complement(3847827..3848486) Escherichia coli O157:H7 str. EDL933 959462 NP_289469.1 CDS yqfB NC_002655.2 3848650 3848961 R hypothetical protein complement(3848650..3848961) Escherichia coli O157:H7 str. EDL933 961936 NP_289470.1 CDS bglA NC_002655.2 3849000 3850439 D 6-phospho-beta-glucosidase 3849000..3850439 Escherichia coli O157:H7 str. EDL933 958383 NP_289471.1 CDS gcvP NC_002655.2 3850605 3853478 R acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; glycine dehydrogenase complement(3850605..3853478) Escherichia coli O157:H7 str. EDL933 961098 NP_289472.1 CDS gcvH NC_002655.2 3853596 3853985 R part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor; glycine cleavage system protein H complement(3853596..3853985) Escherichia coli O157:H7 str. EDL933 960788 NP_289473.1 CDS gcvT NC_002655.2 3854009 3855103 R catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein; glycine cleavage system aminomethyltransferase T complement(3854009..3855103) Escherichia coli O157:H7 str. EDL933 958729 NP_289474.1 CDS visC NC_002655.2 3855551 3856753 R hypothetical protein complement(3855551..3856753) Escherichia coli O157:H7 str. EDL933 958380 NP_289475.1 CDS ubiH NC_002655.2 3856777 3857955 R Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone; 2-octaprenyl-6-methoxyphenyl hydroxylase complement(3856777..3857955) Escherichia coli O157:H7 str. EDL933 959204 NP_289476.1 CDS pepP NC_002655.2 3857952 3859277 R exopeptidase able to cleave the peptide bond of the last amino acid if linked to a proline residue; substrate can be as short as a dipeptide; proline aminopeptidase P II complement(3857952..3859277) Escherichia coli O157:H7 str. EDL933 959337 NP_289477.2 CDS ygfB NC_002655.2 3859303 3859881 R the crystal structure of Haemophilus influenzae HI0817 showed that this protein forms dimers; function unknown; hypothetical protein complement(3859303..3859881) Escherichia coli O157:H7 str. EDL933 958387 NP_289478.1 CDS ygfE NC_002655.2 3860049 3860378 D Z-ring-associated protein 3860049..3860378 Escherichia coli O157:H7 str. EDL933 961267 NP_289479.1 CDS ygfA NC_002655.2 3860678 3861226 D ygfA expression increases five to eight fold in Escherichia coli cells growing as biofilms; unknown function; ligase 3860678..3861226 Escherichia coli O157:H7 str. EDL933 958390 NP_289481.1 CDS serA NC_002655.2 3862008 3863240 R catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; D-3-phosphoglycerate dehydrogenase complement(3862008..3863240) Escherichia coli O157:H7 str. EDL933 959584 NP_289482.1 CDS rpiA NC_002655.2 3863495 3864154 R Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway; ribose-5-phosphate isomerase A complement(3863495..3864154) Escherichia coli O157:H7 str. EDL933 958393 NP_289483.1 CDS iciA NC_002655.2 3864537 3865430 D specific inhibitor of chromosomal initiation of replication in vitro; binds the three 13-mers in the origin (oriC) to block initiation of replication; also controls genes involved in arginine transport; chromosome replication initiation inhibitor protein 3864537..3865430 Escherichia coli O157:H7 str. EDL933 957896 NP_289484.1 CDS sbm NC_002655.2 3865634 3867778 D MDM; functions in conversion of succinate to propionate; methylmalonyl-CoA mutase 3865634..3867778 Escherichia coli O157:H7 str. EDL933 958327 NP_289485.1 CDS ygfD NC_002655.2 3867771 3868766 D functions in transport of arginine/ornithine; inner membrane ATPase that cleaves ATP and phosphorylates two periplasmic proteins that function as two distinct transport systems, the AO (arginine and ornithine) and LAO (lysine, arginine, and ornithine) periplasmic binding proteins; arginine/ornithine transport system ATPase 3867771..3868766 Escherichia coli O157:H7 str. EDL933 958396 NP_289486.2 CDS ygfG NC_002655.2 3868777 3869562 D catalyzes the formation of propanoyl-CoA from methylmalonyl-CoA; methylmalonyl-CoA decarboxylase 3868777..3869562 Escherichia coli O157:H7 str. EDL933 958403 NP_289487.1 CDS ygfH NC_002655.2 3869586 3871064 D coenzyme A transferase 3869586..3871064 Escherichia coli O157:H7 str. EDL933 958395 NP_289488.1 CDS Z4258 NC_002655.2 3871379 3871957 R LysR family transcriptional regulator complement(3871379..3871957) Escherichia coli O157:H7 str. EDL933 958407 NP_289489.1 CDS yggE NC_002655.2 3872124 3872864 R hypothetical protein complement(3872124..3872864) Escherichia coli O157:H7 str. EDL933 958397 NP_289490.1 CDS yggA NC_002655.2 3872957 3873592 R Involved in the export of arginine; arginine exporter protein complement(3872957..3873592) Escherichia coli O157:H7 str. EDL933 959537 NP_289491.1 CDS yggB NC_002655.2 3873731 3874591 R participates in the regulation of osmotic pressure changes within the cel; mechanosensitive ion channel MscS complement(3873731..3874591) Escherichia coli O157:H7 str. EDL933 958316 NP_289492.2 CDS fba NC_002655.2 3874949 3876028 R catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase complement(3874949..3876028) Escherichia coli O157:H7 str. EDL933 958398 NP_289493.1 CDS pgk NC_002655.2 3876243 3877406 R Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase complement(3876243..3877406) Escherichia coli O157:H7 str. EDL933 957143 NP_289494.1 CDS epd NC_002655.2 3877456 3878475 R NAD-dependent; catalyzes the formation of 4-phosphoerythronate from erythrose 4-phosphate in the biosynthesis of pyridoxine 5'-phosphate; erythrose 4-phosphate dehydrogenase complement(3877456..3878475) Escherichia coli O157:H7 str. EDL933 959243 NP_289495.1 CDS Z4267 NC_002655.2 3878847 3879278 D hypothetical protein 3878847..3879278 Escherichia coli O157:H7 str. EDL933 957101 NP_289496.1 CDS Z4268 NC_002655.2 3879301 3879879 D hypothetical protein 3879301..3879879 Escherichia coli O157:H7 str. EDL933 958401 NP_289497.1 CDS Z4269 NC_002655.2 3879880 3880587 D hypothetical protein 3879880..3880587 Escherichia coli O157:H7 str. EDL933 958418 NP_289498.1 CDS Z4270 NC_002655.2 3880575 3881252 D ABC transporter ATP-binding protein 3880575..3881252 Escherichia coli O157:H7 str. EDL933 959364 NP_289499.1 CDS Z4271 NC_002655.2 3881213 3881923 D ABC transporter ATP-binding protein 3881213..3881923 Escherichia coli O157:H7 str. EDL933 958169 NP_289500.1 CDS frcK NC_002655.2 3881895 3882608 R fructose transport system kinase complement(3881895..3882608) Escherichia coli O157:H7 str. EDL933 958405 NP_289501.1 CDS yggD NC_002655.2 3882605 3883114 R DNA-binding transcriptional regulator complement(3882605..3883114) Escherichia coli O157:H7 str. EDL933 958338 NP_289502.1 CDS yggF NC_002655.2 3883136 3884101 R fructose-1,6-bisphosphatase II-like protein complement(3883136..3884101) Escherichia coli O157:H7 str. EDL933 958468 NP_289503.1 CDS Z4276 NC_002655.2 3884098 3885087 R oxidoreductase complement(3884098..3885087) Escherichia coli O157:H7 str. EDL933 958409 NP_289504.1 CDS cmtA NC_002655.2 3885390 3886778 R PTS system, mannitol-specific enzyme II component, cryptic complement(3885390..3886778) Escherichia coli O157:H7 str. EDL933 958491 NP_289505.1 CDS cmtB NC_002655.2 3886806 3887249 R TolM; with CmtA (IIBC), CmtB possibly forms the mannitol-like permease component of the cryptic mannitol phosphotransferase system, which phosphorylates and transports various carbohydrates and polyhydric alcohols in Escherichia coli; cytoplasmic protein; mannitol phosphotransferase subunit EIIA complement(3886806..3887249) Escherichia coli O157:H7 str. EDL933 959538 NP_289506.1 CDS tktA NC_002655.2 3887563 3889554 R catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase complement(3887563..3889554) Escherichia coli O157:H7 str. EDL933 958486 NP_289507.1 CDS yggG NC_002655.2 3889706 3890590 D hypothetical protein 3889706..3890590 Escherichia coli O157:H7 str. EDL933 958413 NP_289508.1 CDS speB NC_002655.2 3890796 3891716 R catalyzes the formation of putrescine from agmatine; agmatinase complement(3890796..3891716) Escherichia coli O157:H7 str. EDL933 958399 NP_289509.1 CDS Z4282 NC_002655.2 3891852 3892583 R No significant matches; hypothetical protein complement(3891852..3892583) Escherichia coli O157:H7 str. EDL933 958414 NP_289510.1 CDS speA NC_002655.2 3892729 3894705 R catalyzes the formation of agmatine from arginine in putrescine and spermidine biosynthesis; arginine decarboxylase complement(3892729..3894705) Escherichia coli O157:H7 str. EDL933 958416 NP_289511.1 CDS yqgB NC_002655.2 3894714 3894860 R hypothetical protein complement(3894714..3894860) Escherichia coli O157:H7 str. EDL933 958428 NP_289512.1 CDS yqgC NC_002655.2 3894981 3895196 D hypothetical protein 3894981..3895196 Escherichia coli O157:H7 str. EDL933 958430 NP_289513.1 CDS yqgD NC_002655.2 3895193 3895444 R hypothetical protein complement(3895193..3895444) Escherichia coli O157:H7 str. EDL933 958432 NP_289514.1 CDS metK NC_002655.2 3895500 3896654 D methionine adenosyltransferase; catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 3895500..3896654 Escherichia coli O157:H7 str. EDL933 958421 NP_289515.1 CDS galP NC_002655.2 3897091 3898485 D galactose-proton symport of transport system 3897091..3898485 Escherichia coli O157:H7 str. EDL933 958406 NP_289516.1 CDS sprT NC_002655.2 3898562 3899059 D hypothetical protein 3898562..3899059 Escherichia coli O157:H7 str. EDL933 958420 NP_289517.1 CDS endA NC_002655.2 3899154 3899861 D DNA-specific endonuclease I 3899154..3899861 Escherichia coli O157:H7 str. EDL933 958408 NP_289518.2 CDS yggJ NC_002655.2 3899941 3900672 D in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE 3899941..3900672 Escherichia coli O157:H7 str. EDL933 958425 NP_289519.1 CDS gshB NC_002655.2 3900685 3901632 D catalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione; glutathione synthetase 3900685..3901632 Escherichia coli O157:H7 str. EDL933 958424 NP_289520.2 CDS yqgE NC_002655.2 3901744 3902307 D hypothetical protein 3901744..3902307 Escherichia coli O157:H7 str. EDL933 959535 NP_289521.1 CDS yqgF NC_002655.2 3902307 3902723 D similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein 3902307..3902723 Escherichia coli O157:H7 str. EDL933 958382 NP_289522.1 CDS yggR NC_002655.2 3902918 3903943 R protein transport complement(3902918..3903943) Escherichia coli O157:H7 str. EDL933 958431 NP_289523.1 CDS yggS NC_002655.2 3903916 3904620 D hypothetical protein 3903916..3904620 Escherichia coli O157:H7 str. EDL933 958162 NP_289524.1 CDS yggT NC_002655.2 3904638 3905204 D resistance protein 3904638..3905204 Escherichia coli O157:H7 str. EDL933 957823 NP_289525.2 CDS yggU NC_002655.2 3905201 3905491 D hypothetical protein 3905201..3905491 Escherichia coli O157:H7 str. EDL933 958419 NP_289526.1 CDS yggV NC_002655.2 3905499 3906092 D HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; deoxyribonucleotide triphosphate pyrophosphatase 3905499..3906092 Escherichia coli O157:H7 str. EDL933 958435 NP_289527.1 CDS yggW NC_002655.2 3906085 3907221 D catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 3906085..3907221 Escherichia coli O157:H7 str. EDL933 958219 NP_289528.1 CDS yggM NC_002655.2 3907464 3908471 R alpha helix chain complement(3907464..3908471) Escherichia coli O157:H7 str. EDL933 958436 NP_289529.1 CDS ansB NC_002655.2 3908588 3909634 R catalyzes the formation of aspartate from asparagine, periplasmic; regulated by cyclic AMP receptor protein (CRP) and also induced by anaerobiosis; L-asparaginase II complement(3908588..3909634) Escherichia coli O157:H7 str. EDL933 961194 NP_289530.1 CDS yggN NC_002655.2 3909810 3910529 R hypothetical protein complement(3909810..3910529) Escherichia coli O157:H7 str. EDL933 961166 NP_289531.2 CDS yggL NC_002655.2 3910713 3911039 R hypothetical protein complement(3910713..3911039) Escherichia coli O157:H7 str. EDL933 958438 NP_289532.1 CDS trmB NC_002655.2 3911039 3911758 R tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase complement(3911039..3911758) Escherichia coli O157:H7 str. EDL933 958423 NP_289533.1 CDS mutY NC_002655.2 3911919 3912971 D adenine DNA glycosylase 3911919..3912971 Escherichia coli O157:H7 str. EDL933 958446 NP_289534.1 CDS yggX NC_002655.2 3912999 3913274 D hypothetical protein 3912999..3913274 Escherichia coli O157:H7 str. EDL933 958439 NP_289535.1 CDS mltC NC_002655.2 3913336 3914418 D Murein hydrolase C; membrane-bound; lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; murein transglycosylase C 3913336..3914418 Escherichia coli O157:H7 str. EDL933 958440 NP_289536.1 CDS nupG NC_002655.2 3914572 3915876 D transport of nucleosides, permease 3914572..3915876 Escherichia coli O157:H7 str. EDL933 958452 NP_289537.1 CDS speC NC_002655.2 3915926 3918121 R ornithine decarboxylase complement(3915926..3918121) Escherichia coli O157:H7 str. EDL933 958455 NP_289538.1 CDS yqgA NC_002655.2 3918459 3919166 D transporter 3918459..3919166 Escherichia coli O157:H7 str. EDL933 958442 NP_289539.1 CDS Z4313 NC_002655.2 3919545 3920810 D pathogenicity island integrase 3919545..3920810 Escherichia coli O157:H7 str. EDL933 956707 NP_289540.2 CDS Z4314 NC_002655.2 3920927 3921712 R hypothetical protein complement(3920927..3921712) Escherichia coli O157:H7 str. EDL933 957179 NP_289541.1 CDS Z4315 NC_002655.2 3921801 3922475 D hypothetical protein 3921801..3922475 Escherichia coli O157:H7 str. EDL933 958449 NP_289542.1 CDS Z4316 NC_002655.2 3922472 3922819 D hypothetical protein 3922472..3922819 Escherichia coli O157:H7 str. EDL933 958456 NP_289543.1 CDS Z4317 NC_002655.2 3922839 3924287 D hypothetical protein 3922839..3924287 Escherichia coli O157:H7 str. EDL933 958460 NP_289544.1 CDS Z4318 NC_002655.2 3924088 3925032 R hypothetical protein complement(3924088..3925032) Escherichia coli O157:H7 str. EDL933 958457 NP_289545.1 CDS Z4320 NC_002655.2 3924862 3924936 D No significant matches; hypothetical protein 3924862..3924936 Escherichia coli O157:H7 str. EDL933 958451 NP_289546.1 CDS Z4321 NC_002655.2 3925141 3925674 R PagC-like membrane protein complement(3925141..3925674) Escherichia coli O157:H7 str. EDL933 961193 NP_289547.1 CDS Z4322 NC_002655.2 3926262 3926462 R No significant matches; hypothetical protein complement(3926262..3926462) Escherichia coli O157:H7 str. EDL933 958426 NP_289548.1 CDS Z4323 NC_002655.2 3926749 3927303 R No significant matches; hypothetical protein complement(3926749..3927303) Escherichia coli O157:H7 str. EDL933 958341 NP_289549.1 CDS Z4324 NC_002655.2 3927142 3927882 D transposase 3927142..3927882 Escherichia coli O157:H7 str. EDL933 958453 NP_289550.1 CDS Z4325 NC_002655.2 3928356 3928526 D No significant matches; hypothetical protein 3928356..3928526 Escherichia coli O157:H7 str. EDL933 958417 NP_289551.1 CDS Z4326 NC_002655.2 3928670 3930319 D enterotoxin 3928670..3930319 Escherichia coli O157:H7 str. EDL933 956950 NP_289553.1 CDS Z4328 NC_002655.2 3930927 3931916 D hypothetical protein 3930927..3931916 Escherichia coli O157:H7 str. EDL933 958461 NP_289554.1 CDS Z4329 NC_002655.2 3931965 3932639 D No significant matches; hypothetical protein 3931965..3932639 Escherichia coli O157:H7 str. EDL933 958464 NP_289555.1 CDS Z4330 NC_002655.2 3933017 3933862 D transposase 3933017..3933862 Escherichia coli O157:H7 str. EDL933 958465 NP_289557.1 CDS Z4332 NC_002655.2 3934514 3935815 D cytotoxin 3934514..3935815 Escherichia coli O157:H7 str. EDL933 956959 NP_289558.1 CDS Z4333 NC_002655.2 3935821 3936648 D cytotoxin 3935821..3936648 Escherichia coli O157:H7 str. EDL933 958282 NP_289559.1 CDS Z4334 NC_002655.2 3936688 3937335 R IS629 transposase complement(3936688..3937335) Escherichia coli O157:H7 str. EDL933 958459 NP_289560.1 CDS Z4335 NC_002655.2 3937575 3937901 R hypothetical protein complement(3937575..3937901) Escherichia coli O157:H7 str. EDL933 957274 NP_289561.1 CDS Z4336 NC_002655.2 3938092 3938439 D hypothetical protein 3938092..3938439 Escherichia coli O157:H7 str. EDL933 957180 NP_289562.1 CDS Z4337 NC_002655.2 3938489 3940027 D hypothetical protein 3938489..3940027 Escherichia coli O157:H7 str. EDL933 959251 NP_289563.1 CDS Z4338 NC_002655.2 3940250 3940600 D hypothetical protein 3940250..3940600 Escherichia coli O157:H7 str. EDL933 958462 NP_289564.1 CDS Z4340 NC_002655.2 3940813 3942216 D hypothetical protein 3940813..3942216 Escherichia coli O157:H7 str. EDL933 958467 NP_289565.1 CDS pitB NC_002655.2 3942722 3944038 R transporter complement(3942722..3944038) Escherichia coli O157:H7 str. EDL933 958466 NP_289566.1 CDS gsp NC_002655.2 3944330 3946189 R catalyzes the formation of glutathionylspermidine from glutathione and spermidine; also catalyzes the reverse reaction; bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase complement(3944330..3946189) Escherichia coli O157:H7 str. EDL933 958472 NP_289567.1 CDS Z4343 NC_002655.2 3946346 3947260 D YghU; B2989; one of eight glutathione transferases from E. coli; glutathione S-transferase 3946346..3947260 Escherichia coli O157:H7 str. EDL933 958471 NP_289568.1 CDS hybG NC_002655.2 3947383 3947631 R hydrogenase 2 accessory protein HypG complement(3947383..3947631) Escherichia coli O157:H7 str. EDL933 958474 NP_289569.1 CDS hypA NC_002655.2 3947644 3947985 R plays a role in hydrogenase nickel cofactor insertion; hydrogenase nickel incorporation protein HybF complement(3947644..3947985) Escherichia coli O157:H7 str. EDL933 958485 NP_289570.1 CDS hybE NC_002655.2 3947978 3948466 R hydrogenase 2-specific chaperone complement(3947978..3948466) Escherichia coli O157:H7 str. EDL933 958475 NP_289571.1 CDS hybD NC_002655.2 3948459 3948953 R protease responsible for the cleavage of a 15 amino acid peptide from the C-terminal end of the large subunit of hydrogenase 2 (HybC); hydrogenase 2 maturation endopeptidase complement(3948459..3948953) Escherichia coli O157:H7 str. EDL933 958483 NP_289572.1 CDS hybC NC_002655.2 3948953 3950656 R involved in hydrogen uptake; hydrogenase 2 large subunit complement(3948953..3950656) Escherichia coli O157:H7 str. EDL933 958476 NP_289573.1 CDS hybB NC_002655.2 3950653 3951831 R HybB; cytochrome b subunit of the hydrogenase 2 enzyme, composed of HybA, B, C, and O subunits; hydrogenase 2 b cytochrome subunit complement(3950653..3951831) Escherichia coli O157:H7 str. EDL933 958480 NP_289574.1 CDS hybA NC_002655.2 3951821 3952807 R Fe-S ferrodoxin type component; participates in the periplasmic electron-transferring activity of hydrogenase 2; hydrogenase 2 protein HybA complement(3951821..3952807) Escherichia coli O157:H7 str. EDL933 958469 NP_289575.1 CDS Z4351 NC_002655.2 3952810 3953928 R involved in hydrogen uptake; hydrogenase 2 small subunit complement(3952810..3953928) Escherichia coli O157:H7 str. EDL933 958478 NP_289576.1 CDS Z4352 NC_002655.2 3954117 3954404 R hypothetical protein complement(3954117..3954404) Escherichia coli O157:H7 str. EDL933 958320 NP_289577.1 CDS Z4353 NC_002655.2 3954523 3955449 R hypothetical protein complement(3954523..3955449) Escherichia coli O157:H7 str. EDL933 958477 NP_289578.1 CDS Z4354 NC_002655.2 3955567 3956607 D aldo/keto reductase 3955567..3956607 Escherichia coli O157:H7 str. EDL933 958479 NP_289579.1 CDS yqhA NC_002655.2 3956647 3957141 R hypothetical protein complement(3956647..3957141) Escherichia coli O157:H7 str. EDL933 957436 NP_289580.1 CDS yghA NC_002655.2 3957332 3958216 D oxidoreductase 3957332..3958216 Escherichia coli O157:H7 str. EDL933 961274 NP_289581.1 CDS Z4357 NC_002655.2 3958392 3958637 D hypothetical protein 3958392..3958637 Escherichia coli O157:H7 str. EDL933 961277 NP_289582.1 CDS exbD NC_002655.2 3958488 3958913 R membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell; biopolymer transport protein ExbD complement(3958488..3958913) Escherichia coli O157:H7 str. EDL933 958487 NP_289583.1 CDS exbB NC_002655.2 3958920 3959654 R membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell; biopolymer transport protein ExbB complement(3958920..3959654) Escherichia coli O157:H7 str. EDL933 959561 NP_289584.1 CDS Z4360 NC_002655.2 3959647 3959802 R hypothetical protein complement(3959647..3959802) Escherichia coli O157:H7 str. EDL933 961969 NP_289585.1 CDS metC NC_002655.2 3959906 3961093 D catalyzes the formation of L-homocysteine from cystathionine; cystathionine beta-lyase 3959906..3961093 Escherichia coli O157:H7 str. EDL933 958488 NP_289586.1 CDS yghB NC_002655.2 3961233 3961892 D hypothetical protein 3961233..3961892 Escherichia coli O157:H7 str. EDL933 961339 NP_289587.1 CDS yqhC NC_002655.2 3961932 3963059 R AraC family transcriptional regulator complement(3961932..3963059) Escherichia coli O157:H7 str. EDL933 961329 NP_289588.1 CDS yqhD NC_002655.2 3963025 3964188 D oxidoreductase 3963025..3964188 Escherichia coli O157:H7 str. EDL933 959332 NP_289589.2 CDS dkgA NC_002655.2 3964293 3965120 D methylglyoxal reductase/#-keto ester reductase; catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid; also catalyzes the reduction of methylglyoxal, ethyl-2-methylacetoacetate and ethyl-acetoacetate; 2,5-diketo-D-gluconate reductase A 3964293..3965120 Escherichia coli O157:H7 str. EDL933 957304 NP_289590.1 CDS Z4367 NC_002655.2 3965321 3965596 D hypothetical protein 3965321..3965596 Escherichia coli O157:H7 str. EDL933 958492 NP_289591.2 CDS yqhG NC_002655.2 3965590 3966243 D hypothetical protein 3965590..3966243 Escherichia coli O157:H7 str. EDL933 958494 NP_289592.1 CDS yqhH NC_002655.2 3966292 3966549 D outer membrane lipoprotein 3966292..3966549 Escherichia coli O157:H7 str. EDL933 958495 NP_289593.1 CDS Z4370 NC_002655.2 3966592 3968811 R hypothetical protein complement(3966592..3968811) Escherichia coli O157:H7 str. EDL933 958500 NP_289594.1 CDS sufI NC_002655.2 3968922 3970334 R repressor protein for FtsI complement(3968922..3970334) Escherichia coli O157:H7 str. EDL933 958496 NP_289595.1 CDS plsC NC_002655.2 3970409 3971146 R 1-acyl-sn-glycerol-3-phosphate acyltransferase complement(3970409..3971146) Escherichia coli O157:H7 str. EDL933 958493 NP_289596.1 CDS parC NC_002655.2 3971380 3973638 R decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit A complement(3971380..3973638) Escherichia coli O157:H7 str. EDL933 958400 NP_289597.1 CDS Z4374 NC_002655.2 3973776 3975383 R YgiS; uncharacterized periplasmic protein that seems to be part of a binding-protein-dependent transport system; hypothetical protein complement(3973776..3975383) Escherichia coli O157:H7 str. EDL933 958499 NP_289598.1 CDS Z4375 NC_002655.2 3975492 3975974 R hypothetical protein complement(3975492..3975974) Escherichia coli O157:H7 str. EDL933 958702 NP_289599.1 CDS ygiW NC_002655.2 3976027 3976419 R hypothetical protein complement(3976027..3976419) Escherichia coli O157:H7 str. EDL933 958347 NP_289600.1 CDS qseB NC_002655.2 3976571 3977230 D QseB; response regulator in two-component regulatory system with QseC; regulates FlhCD which is the master regulator for flagella and motility genes; DNA-binding transcriptional regulator QseB 3976571..3977230 Escherichia coli O157:H7 str. EDL933 958498 NP_289601.1 CDS qseC NC_002655.2 3977227 3978576 D QseC; sensor protein QseC 3977227..3978576 Escherichia coli O157:H7 str. EDL933 958502 NP_289602.1 CDS mdaB NC_002655.2 3978686 3979267 D modulator of drug activity B 3978686..3979267 Escherichia coli O157:H7 str. EDL933 958510 NP_289603.1 CDS ygiN NC_002655.2 3979298 3979612 D hypothetical protein 3979298..3979612 Escherichia coli O157:H7 str. EDL933 958514 NP_289604.1 CDS Z4381 NC_002655.2 3979657 3980544 R hypothetical protein complement(3979657..3980544) Escherichia coli O157:H7 str. EDL933 956887 NP_289605.1 CDS Z4382 NC_002655.2 3980541 3981488 R iron ABC transporter substrate-binding protein complement(3980541..3981488) Escherichia coli O157:H7 str. EDL933 959283 NP_289606.1 CDS Z4383 NC_002655.2 3981499 3982548 R iron ABC transporter permease complement(3981499..3982548) Escherichia coli O157:H7 str. EDL933 958504 NP_289607.1 CDS Z4384 NC_002655.2 3982545 3983528 R iron ABC transporter permease complement(3982545..3983528) Escherichia coli O157:H7 str. EDL933 958513 NP_289608.1 CDS Z4385 NC_002655.2 3983525 3984334 R ABC transporter ATP-binding protein complement(3983525..3984334) Escherichia coli O157:H7 str. EDL933 958505 NP_289609.1 CDS Z4386 NC_002655.2 3984708 3986849 D iron compound receptor 3984708..3986849 Escherichia coli O157:H7 str. EDL933 958501 NP_289610.1 CDS parE NC_002655.2 3986913 3988805 R decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit B complement(3986913..3988805) Escherichia coli O157:H7 str. EDL933 958226 NP_289611.1 CDS yqiA NC_002655.2 3988834 3989415 R Displays esterase activity toward palmitoyl-CoA and pNP-butyrate; esterase complement(3988834..3989415) Escherichia coli O157:H7 str. EDL933 958506 NP_289612.1 CDS icc NC_002655.2 3989415 3990242 R cyclic 3',5'-adenosine monophosphate phosphodiesterase complement(3989415..3990242) Escherichia coli O157:H7 str. EDL933 958507 NP_289613.1 CDS yqiB NC_002655.2 3990267 3990689 R hypothetical protein complement(3990267..3990689) Escherichia coli O157:H7 str. EDL933 959516 NP_289614.1 CDS nudF NC_002655.2 3990690 3991319 R ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose; ADP-ribose pyrophosphatase complement(3990690..3991319) Escherichia coli O157:H7 str. EDL933 961965 NP_289615.2 CDS tolC NC_002655.2 3991524 3993005 D trimeric outer membrane protein involved in efflux of hydrophobic/amphipathic molecules; functions with a number of efflux systems in the inner membrane to transport molecules out of the cell; outer membrane channel protein 3991524..3993005 Escherichia coli O157:H7 str. EDL933 958511 NP_289616.1 CDS ygiA NC_002655.2 3993005 3993265 D hypothetical protein 3993005..3993265 Escherichia coli O157:H7 str. EDL933 958512 NP_289617.2 CDS ygiB NC_002655.2 3993153 3993824 D hypothetical protein 3993153..3993824 Escherichia coli O157:H7 str. EDL933 959515 NP_289618.1 CDS ygiC NC_002655.2 3993830 3994990 D synthetase/amidase 3993830..3994990 Escherichia coli O157:H7 str. EDL933 961964 NP_289619.1 CDS ygiD NC_002655.2 3995028 3995843 R seems to be involved in biofilm formation; in asymptomatic bacteriuria E. coli strains 83972 and VR50, the ygiD gene is upregulated during biofilm formation in urine; hypothetical protein complement(3995028..3995843) Escherichia coli O157:H7 str. EDL933 958515 NP_289620.1 CDS ygiE NC_002655.2 3995959 3996732 D zinc transporter ZupT 3995959..3996732 Escherichia coli O157:H7 str. EDL933 958516 NP_289621.1 CDS Z4398 NC_002655.2 3996790 3996960 R No significant matches; hypothetical protein complement(3996790..3996960) Escherichia coli O157:H7 str. EDL933 961335 NP_289622.1 CDS ribB NC_002655.2 3997222 3997875 R DHBP synthase; functions during riboflavin biosynthesis; 3,4-dihydroxy-2-butanone 4-phosphate synthase complement(3997222..3997875) Escherichia coli O157:H7 str. EDL933 961299 NP_289623.1 CDS Z4400 NC_002655.2 3998213 3998548 D hypothetical protein 3998213..3998548 Escherichia coli O157:H7 str. EDL933 961425 NP_289624.1 CDS glgS NC_002655.2 3998583 3998789 R Involved in glycogen synthesis. May be involved in glycogen priming; glycogen synthesis protein GlgS complement(3998583..3998789) Escherichia coli O157:H7 str. EDL933 959514 NP_289625.1 CDS Z4402 NC_002655.2 3999052 3999666 D oxidoreductase 3999052..3999666 Escherichia coli O157:H7 str. EDL933 961963 NP_289626.1 CDS Z4403 NC_002655.2 3999708 4001369 D hypothetical protein 3999708..4001369 Escherichia coli O157:H7 str. EDL933 958520 NP_289627.1 CDS Z4405 NC_002655.2 4002163 4003596 R catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate to form D,D-heptose-1,7-bisphosphate and catalyzes transfer of ADP to D-glycero-D-manno-heptose 1-phosphate forming ADP-D,D-heptose; bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase complement(4002163..4003596) Escherichia coli O157:H7 str. EDL933 958521 NP_289628.1 CDS glnE NC_002655.2 4003644 4006484 R catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme; bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase complement(4003644..4006484) Escherichia coli O157:H7 str. EDL933 959563 NP_289629.1 CDS ygiF NC_002655.2 4006507 4007808 R hypothetical protein complement(4006507..4007808) Escherichia coli O157:H7 str. EDL933 958526 NP_289630.1 CDS ygiM NC_002655.2 4008050 4008670 D signal transduction protein 4008050..4008670 Escherichia coli O157:H7 str. EDL933 958527 NP_289631.1 CDS cca NC_002655.2 4008734 4009972 D catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template; phosphohydrolase activities include hydrolysis of pyrophosphate, 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP with the production of Pi, metal-dependent phosphodiesterase activity for 2',3'-cAMP, 2',3'-cGMP, and 2',3'-cCMP, and hydrolysis 2',3'-cyclic substrates with the formation of 2'-nucleotides and 3'-nucleotides; these phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases; multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase 4008734..4009972 Escherichia coli O157:H7 str. EDL933 958528 NP_289632.1 CDS uppP NC_002655.2 4010153 4010974 R BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell; undecaprenyl pyrophosphate phosphatase complement(4010153..4010974) Escherichia coli O157:H7 str. EDL933 958529 NP_289633.1 CDS folB NC_002655.2 4011065 4011436 R catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin and can also catalyze the epimerization of carbon 2' of dihydroneopterin and dihydromonapterin; bifunctional dihydroneopterin aldolase/dihydroneopterin triphosphate 2'-epimerase complement(4011065..4011436) Escherichia coli O157:H7 str. EDL933 958519 NP_289634.1 CDS ygiH NC_002655.2 4011539 4012156 D involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX; glycerol-3-phosphate acyltransferase PlsY 4011539..4012156 Escherichia coli O157:H7 str. EDL933 959565 NP_289635.1 CDS ygiP NC_002655.2 4012169 4013101 R activates expression of genes required for L-tartrate-dependent anaerobic growth on glycerol; transcriptional activator TtdR complement(4012169..4013101) Escherichia coli O157:H7 str. EDL933 961971 NP_289636.1 CDS ttdA NC_002655.2 4013308 4014219 D Involved in the tartrate degradation pathway; tartrate dehydratase subunit alpha 4013308..4014219 Escherichia coli O157:H7 str. EDL933 958530 NP_289637.1 CDS ttdB NC_002655.2 4014216 4014821 D Involved in the tartrate degradation pathway; L(+)-tartrate dehydratase subunit beta 4014216..4014821 Escherichia coli O157:H7 str. EDL933 958372 NP_289638.1 CDS ygjE NC_002655.2 4014870 4016333 D hypothetical protein 4014870..4016333 Escherichia coli O157:H7 str. EDL933 961221 NP_289639.1 CDS ygjD NC_002655.2 4016376 4017389 R in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; DNA-binding/iron metalloprotein/AP endonuclease complement(4016376..4017389) Escherichia coli O157:H7 str. EDL933 959257 NP_289640.1 CDS rpsU NC_002655.2 4017627 4017842 D a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 4017627..4017842 Escherichia coli O157:H7 str. EDL933 958532 NP_289641.1 CDS dnaG NC_002655.2 4017953 4019698 D synthesizes RNA primers at the replication forks; DNA primase 4017953..4019698 Escherichia coli O157:H7 str. EDL933 958533 NP_289642.1 CDS rpoD NC_002655.2 4019893 4021734 D sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria; RNA polymerase sigma factor RpoD 4019893..4021734 Escherichia coli O157:H7 str. EDL933 958534 NP_289643.1 CDS ygjF NC_002655.2 4021813 4022319 R G/U mismatch-specific DNA glycosylase complement(4021813..4022319) Escherichia coli O157:H7 str. EDL933 958536 NP_289644.1 CDS yqjH NC_002655.2 4022573 4023337 R hypothetical protein complement(4022573..4023337) Escherichia coli O157:H7 str. EDL933 958551 NP_289645.1 CDS yqjI NC_002655.2 4023625 4024248 D hypothetical protein 4023625..4024248 Escherichia coli O157:H7 str. EDL933 960239 NP_289646.1 CDS aer NC_002655.2 4024402 4025922 R aerotaxis sensor receptor, flavoprotein complement(4024402..4025922) Escherichia coli O157:H7 str. EDL933 958561 NP_289647.2 CDS ygjG NC_002655.2 4026313 4027719 D catalyzes the formation of 4-aminobutyraldehyde from putrescine and 2-oxoglutarate; putrescine--2-oxoglutarate aminotransferase 4026313..4027719 Escherichia coli O157:H7 str. EDL933 958552 NP_289648.1 CDS ygjH NC_002655.2 4027761 4028093 R hypothetical protein complement(4027761..4028093) Escherichia coli O157:H7 str. EDL933 961517 NP_289649.1 CDS ebgR NC_002655.2 4028312 4029295 D DNA-binding transcriptional repressor EbgR 4028312..4029295 Escherichia coli O157:H7 str. EDL933 958572 NP_289650.2 CDS ebgA NC_002655.2 4029479 4032571 D in Escherichia coli this is the second beta-galactosidase system; cryptic beta-D-galactosidase subunit alpha 4029479..4032571 Escherichia coli O157:H7 str. EDL933 961444 NP_289651.1 CDS ebgC NC_002655.2 4032568 4033017 D in Escherichia coli this is the second beta-galactosidase system; cryptic beta-D-galactosidase subunit beta 4032568..4033017 Escherichia coli O157:H7 str. EDL933 958555 NP_289652.1 CDS ygjI NC_002655.2 4033080 4034513 D oxidoreductase 4033080..4034513 Escherichia coli O157:H7 str. EDL933 958556 NP_289653.1 CDS ygjJ NC_002655.2 4034647 4035717 D hypothetical protein 4034647..4035717 Escherichia coli O157:H7 str. EDL933 960426 NP_289654.1 CDS ygjK NC_002655.2 4035734 4038085 D glycosyl hydrolase 4035734..4038085 Escherichia coli O157:H7 str. EDL933 958786 NP_289655.1 CDS ygjL NC_002655.2 4038511 4040529 D NADPH dehydrogenase 4038511..4040529 Escherichia coli O157:H7 str. EDL933 960277 NP_289656.1 CDS ygjM NC_002655.2 4040574 4040990 R hypothetical protein complement(4040574..4040990) Escherichia coli O157:H7 str. EDL933 956720 NP_289657.1 CDS ygjN NC_002655.2 4040987 4041301 R hypothetical protein complement(4040987..4041301) Escherichia coli O157:H7 str. EDL933 958558 NP_289658.1 CDS ygjO NC_002655.2 4041585 4042721 R hypothetical protein complement(4041585..4042721) Escherichia coli O157:H7 str. EDL933 959810 NP_289659.1 CDS ygjP NC_002655.2 4042770 4043309 D hypothetical protein 4042770..4043309 Escherichia coli O157:H7 str. EDL933 960962 NP_289660.1 CDS ygjQ NC_002655.2 4043386 4044078 D hypothetical protein 4043386..4044078 Escherichia coli O157:H7 str. EDL933 958559 NP_289661.1 CDS ygjR NC_002655.2 4044139 4045143 D hypothetical protein 4044139..4045143 Escherichia coli O157:H7 str. EDL933 958059 NP_289662.1 CDS ygjT NC_002655.2 4045427 4046392 D transporter 4045427..4046392 Escherichia coli O157:H7 str. EDL933 960979 NP_289663.1 CDS ygjU NC_002655.2 4046791 4048035 D involved in the import of serine and threonine coupled with the import of sodium; serine/threonine transporter SstT 4046791..4048035 Escherichia coli O157:H7 str. EDL933 958142 NP_289664.1 CDS ygjV NC_002655.2 4048040 4048591 R hypothetical protein complement(4048040..4048591) Escherichia coli O157:H7 str. EDL933 958560 NP_289665.1 CDS uxaA NC_002655.2 4048674 4050161 R altronate hydrolase complement(4048674..4050161) Escherichia coli O157:H7 str. EDL933 958562 NP_289666.1 CDS uxaC NC_002655.2 4050176 4051588 R catalyzes the interconversion of D-glucuronate to D-fructuronate or D-galacturonate to D-tagaturonate; functions in glucuronic and galacturonic metabolism; glucuronate isomerase complement(4050176..4051588) Escherichia coli O157:H7 str. EDL933 961442 NP_289667.1 CDS exuT NC_002655.2 4051952 4053370 D transport of hexuronates 4051952..4053370 Escherichia coli O157:H7 str. EDL933 958081 NP_289668.2 CDS exuR NC_002655.2 4053500 4054276 D regulates the exuT, uxaCA and uxuRAB operons which encode genes involved in hexuronate utilization.; DNA-binding transcriptional repressor ExuR 4053500..4054276 Escherichia coli O157:H7 str. EDL933 958563 NP_289669.1 CDS yqjA NC_002655.2 4054621 4055283 D hypothetical protein 4054621..4055283 Escherichia coli O157:H7 str. EDL933 958564 NP_289670.1 CDS yqjB NC_002655.2 4055287 4055670 D hypothetical protein 4055287..4055670 Escherichia coli O157:H7 str. EDL933 958568 NP_289671.2 CDS yqjC NC_002655.2 4055817 4056185 D hypothetical protein 4055817..4056185 Escherichia coli O157:H7 str. EDL933 958569 NP_289672.1 CDS yqjD NC_002655.2 4056223 4056528 D hypothetical protein 4056223..4056528 Escherichia coli O157:H7 str. EDL933 958574 NP_289673.1 CDS yqjE NC_002655.2 4056531 4056935 D hypothetical protein 4056531..4056935 Escherichia coli O157:H7 str. EDL933 958571 NP_289674.1 CDS Z4454 NC_002655.2 4056925 4057224 D hypothetical protein 4056925..4057224 Escherichia coli O157:H7 str. EDL933 958576 NP_289675.1 CDS yqjF NC_002655.2 4057320 4057802 D hypothetical protein 4057320..4057802 Escherichia coli O157:H7 str. EDL933 958578 NP_289676.1 CDS yqjG NC_002655.2 4057872 4058858 D transferase 4057872..4058858 Escherichia coli O157:H7 str. EDL933 958580 NP_289677.1 CDS yhaH NC_002655.2 4059150 4059515 D cytochrome 4059150..4059515 Escherichia coli O157:H7 str. EDL933 957366 NP_289678.1 CDS yhaI NC_002655.2 4059756 4060112 D cytochrome 4059756..4060112 Escherichia coli O157:H7 str. EDL933 958063 NP_289679.1 CDS yhaJ NC_002655.2 4060163 4061059 R LysR family transcriptional regulator complement(4060163..4061059) Escherichia coli O157:H7 str. EDL933 958076 NP_289680.1 CDS yhaK NC_002655.2 4061164 4061865 D hypothetical protein 4061164..4061865 Escherichia coli O157:H7 str. EDL933 958582 NP_289681.1 CDS yhaL NC_002655.2 4061882 4062052 D hypothetical protein 4061882..4062052 Escherichia coli O157:H7 str. EDL933 961198 NP_289682.1 CDS Z4462 NC_002655.2 4062186 4063496 R hypothetical protein complement(4062186..4063496) Escherichia coli O157:H7 str. EDL933 961203 NP_289683.1 CDS yhaO NC_002655.2 4063524 4064855 R transport system permease complement(4063524..4064855) Escherichia coli O157:H7 str. EDL933 960249 NP_289684.1 CDS Z4464 NC_002655.2 4065130 4066500 R L-serine deaminase complement(4065130..4066500) Escherichia coli O157:H7 str. EDL933 958585 NP_289685.1 CDS yhaR NC_002655.2 4066566 4067018 R hypothetical protein complement(4066566..4067018) Escherichia coli O157:H7 str. EDL933 961449 NP_289686.1 CDS tdcE NC_002655.2 4066969 4069263 R formate acetyltransferase 3 complement(4066969..4069263) Escherichia coli O157:H7 str. EDL933 958549 NP_289687.1 CDS tdcD NC_002655.2 4069297 4070517 R catalyzes the formation of propanoyl phosphate from propanoate and ATP; TdcD also has acetate kinase activities and functions in anaerobic threonine catabolism; propionate/acetate kinase complement(4069297..4070517) Escherichia coli O157:H7 str. EDL933 958587 NP_289688.1 CDS tdcC NC_002655.2 4070531 4071862 R involved in the import of threonine and serine in combination with the import of a proton; threonine/serine transporter TdcC complement(4070531..4071862) Escherichia coli O157:H7 str. EDL933 961447 NP_289689.1 CDS tdcB NC_002655.2 4071884 4072873 R catalyzes the formation of 2-oxobutanoate from L-threonine; catabolic; threonine dehydratase complement(4071884..4072873) Escherichia coli O157:H7 str. EDL933 958586 NP_289690.1 CDS tdcA NC_002655.2 4072972 4073910 R regulates the tdcABCDEFG operon which is involved in amino acid degradation; DNA-binding transcriptional activator TdcA complement(4072972..4073910) Escherichia coli O157:H7 str. EDL933 961446 NP_289691.1 CDS tdcR NC_002655.2 4074099 4074443 D participates in controlling the expression of several structural genes for the enzyme threonine dehydratase; TdcR activates the tdcABCDEFG operon; DNA-binding transcriptional activator TdcR 4074099..4074443 Escherichia coli O157:H7 str. EDL933 958589 NP_289692.1 CDS yhaB NC_002655.2 4074678 4075238 D hypothetical protein 4074678..4075238 Escherichia coli O157:H7 str. EDL933 960252 NP_289693.1 CDS yhaC NC_002655.2 4075260 4076447 D hypothetical protein 4075260..4076447 Escherichia coli O157:H7 str. EDL933 959211 NP_289695.2 CDS yhaD NC_002655.2 4077076 4078221 R glycerate kinase complement(4077076..4078221) Escherichia coli O157:H7 str. EDL933 958591 NP_289696.2 CDS garR NC_002655.2 4078318 4079208 R catalyzes the reduction of tartronate semialdehyde to glycerate; tartronate semialdehyde reductase complement(4078318..4079208) Escherichia coli O157:H7 str. EDL933 961202 NP_289697.1 CDS yhaF NC_002655.2 4079238 4080008 R cleaves 5-dehydro-4-deoxy-glucarate and 2-dehydro-3-deoxy-D-glucarate; alpha-dehydro-beta-deoxy-D-glucarate aldolase complement(4079238..4080008) Escherichia coli O157:H7 str. EDL933 958592 NP_289698.1 CDS yhaU NC_002655.2 4080024 4081358 R transporter complement(4080024..4081358) Escherichia coli O157:H7 str. EDL933 958584 NP_289699.1 CDS yhaG NC_002655.2 4081733 4083304 D hydrolase 4081733..4083304 Escherichia coli O157:H7 str. EDL933 958606 NP_289700.1 CDS sohA NC_002655.2 4083453 4083788 D SohA; PrlF; involved in protein secretion; when overproduced or mutated, it induces growth defect and increased export of a reporter protein; a PrlF mutation induces the activity of the Lon protease, and a Lon-deficient strain suppresses the phenotype conferred by the PrlF mutation; regulator PrlF 4083453..4083788 Escherichia coli O157:H7 str. EDL933 958593 NP_289701.1 CDS yhaV NC_002655.2 4083788 4084252 D hypothetical protein 4083788..4084252 Escherichia coli O157:H7 str. EDL933 958363 NP_289702.1 CDS agaR NC_002655.2 4084307 4085116 R transcriptional repressor for the agaZVWA and agaSYBCDI operons; DNA-binding transcriptional regulator AgaR complement(4084307..4085116) Escherichia coli O157:H7 str. EDL933 958202 NP_289703.1 CDS agaZ NC_002655.2 4085365 4086645 D tagatose 6-phosphate kinase 2 4085365..4086645 Escherichia coli O157:H7 str. EDL933 958594 NP_289704.1 CDS agaV NC_002655.2 4086632 4087141 D catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake;involved in N-acetylgalactosamine transport; PTS system N-acetylgalactosamine-specific transporter subunit IIB 4086632..4087141 Escherichia coli O157:H7 str. EDL933 958596 NP_289705.1 CDS Z4486 NC_002655.2 4087152 4087931 D phosphotransferase system enzyme subunit 4087152..4087931 Escherichia coli O157:H7 str. EDL933 959218 NP_289706.1 CDS Z4487 NC_002655.2 4087921 4088799 D phosphotransferase system enzyme subunit 4087921..4088799 Escherichia coli O157:H7 str. EDL933 961206 NP_289707.1 CDS Z4488 NC_002655.2 4088817 4089251 D phosphotransferase system enzyme subunit 4088817..4089251 Escherichia coli O157:H7 str. EDL933 959227 NP_289708.1 CDS Z4489 NC_002655.2 4089248 4090381 D N-acetylgalctosamine-6-phosphate deacetylase 4089248..4090381 Escherichia coli O157:H7 str. EDL933 958598 NP_289709.1 CDS agaS NC_002655.2 4090732 4091886 D tagatose-6-phosphate aldose/ketose isomerase 4090732..4091886 Escherichia coli O157:H7 str. EDL933 959215 NP_289710.1 CDS kbaY NC_002655.2 4091899 4092759 D catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway; tagatose-bisphosphate aldolase 4091899..4092759 Escherichia coli O157:H7 str. EDL933 958597 NP_289711.1 CDS agaB NC_002655.2 4092926 4093402 D catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; involved in N-acetylgalactosamine transport; PTS system N-acetylgalactosamine-specific transporter subunit IIB 4092926..4093402 Escherichia coli O157:H7 str. EDL933 959220 NP_289712.1 CDS agaC NC_002655.2 4093669 4094244 D catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane;protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; involved in N-acetylgalactosamine transport; PTS system N-acetylgalactosamine-specific transporter subunit IIC 4093669..4094244 Escherichia coli O157:H7 str. EDL933 958595 NP_289713.1 CDS agaD NC_002655.2 4094234 4095025 D catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N-acetylgalactosamine transport; PTS system N-acetylgalactosamine-specific transporter subunit IID 4094234..4095025 Escherichia coli O157:H7 str. EDL933 958600 NP_289714.1 CDS agaI NC_002655.2 4095026 4095781 D galactosamine-6-phosphate isomerase 4095026..4095781 Escherichia coli O157:H7 str. EDL933 959638 NP_289715.1 CDS yraH NC_002655.2 4096182 4096766 D fimbrial-like protein 4096182..4096766 Escherichia coli O157:H7 str. EDL933 959441 NP_289716.1 CDS yraI NC_002655.2 4096846 4097541 D chaperone 4096846..4097541 Escherichia coli O157:H7 str. EDL933 959450 NP_289717.1 CDS yraJ NC_002655.2 4097570 4100086 D hypothetical protein 4097570..4100086 Escherichia coli O157:H7 str. EDL933 957181 NP_289718.1 CDS Z4501 NC_002655.2 4099926 4100450 D hypothetical protein 4099926..4100450 Escherichia coli O157:H7 str. EDL933 959296 NP_289719.1 CDS Z4502 NC_002655.2 4100476 4100802 D hypothetical protein 4100476..4100802 Escherichia coli O157:H7 str. EDL933 959239 NP_289720.1 CDS Z4503 NC_002655.2 4101042 4101689 D transposase 4101042..4101689 Escherichia coli O157:H7 str. EDL933 960271 NP_289721.1 CDS Z4504 NC_002655.2 4101655 4102146 D fimbrial protein 4101655..4102146 Escherichia coli O157:H7 str. EDL933 959238 NP_289722.1 CDS yraL NC_002655.2 4102189 4103049 R hypothetical protein complement(4102189..4103049) Escherichia coli O157:H7 str. EDL933 958599 NP_289723.1 CDS yraM NC_002655.2 4103114 4105150 D glycosylase 4103114..4105150 Escherichia coli O157:H7 str. EDL933 958602 NP_289724.1 CDS yraN NC_002655.2 4105108 4105503 D hypothetical protein 4105108..4105503 Escherichia coli O157:H7 str. EDL933 959252 NP_289725.1 CDS yraO NC_002655.2 4105523 4106113 D Required for the timely initiation of chromosomal replication via direct interactions with the dnaA initiator protein; chromosome replication initiator DnaA 4105523..4106113 Escherichia coli O157:H7 str. EDL933 961219 NP_289726.1 CDS yraP NC_002655.2 4106123 4106698 D hypothetical protein 4106123..4106698 Escherichia coli O157:H7 str. EDL933 959254 NP_289727.1 CDS yraQ NC_002655.2 4106812 4107852 R hypothetical protein complement(4106812..4107852) Escherichia coli O157:H7 str. EDL933 958603 NP_289728.1 CDS yraR NC_002655.2 4107925 4108605 R hypothetical protein complement(4107925..4108605) Escherichia coli O157:H7 str. EDL933 959246 NP_289729.1 CDS yhbO NC_002655.2 4108646 4109206 D hypothetical protein 4108646..4109206 Escherichia coli O157:H7 str. EDL933 959258 NP_289730.1 CDS yhbP NC_002655.2 4109186 4109629 R hypothetical protein complement(4109186..4109629) Escherichia coli O157:H7 str. EDL933 959216 NP_289731.1 CDS yhbQ NC_002655.2 4109680 4109982 D GIY-YIG nuclease superfamily protein 4109680..4109982 Escherichia coli O157:H7 str. EDL933 959214 NP_289732.1 CDS yhbS NC_002655.2 4109969 4110472 R hypothetical protein complement(4109969..4110472) Escherichia coli O157:H7 str. EDL933 958604 NP_289733.1 CDS yhbT NC_002655.2 4110466 4110990 R hypothetical protein complement(4110466..4110990) Escherichia coli O157:H7 str. EDL933 959247 NP_289734.1 CDS yhbU NC_002655.2 4111199 4112194 D collagenase 4111199..4112194 Escherichia coli O157:H7 str. EDL933 959250 NP_289735.1 CDS yhbV NC_002655.2 4112185 4113081 D hypothetical protein 4112185..4113081 Escherichia coli O157:H7 str. EDL933 961217 NP_289736.1 CDS yhbW NC_002655.2 4113162 4114169 D hypothetical protein 4113162..4114169 Escherichia coli O157:H7 str. EDL933 959248 NP_289737.1 CDS mtr NC_002655.2 4114286 4115530 R tryptophan transporter of high affinity; tryptophan permease complement(4114286..4115530) Escherichia coli O157:H7 str. EDL933 958605 NP_289738.2 CDS deaD NC_002655.2 4115684 4117573 R participates in the assembly of the large subunit of the ribosome; plays a key role in optimal cell growth at low temperature and is required for normal cell division; ATP-dependent RNA helicase DeaD complement(4115684..4117573) Escherichia coli O157:H7 str. EDL933 958607 NP_289739.1 CDS yhbM NC_002655.2 4117753 4118637 R lipoprotein that appears to be involved in cell division; interacts with the periplasmic protease Prc and may be activated by protease processing; lipoprotein NlpI complement(4117753..4118637) Escherichia coli O157:H7 str. EDL933 958608 NP_289740.1 CDS pnp NC_002655.2 4118746 4120950 R polynucleotide phosphorylase complement(4118746..4120950) Escherichia coli O157:H7 str. EDL933 958609 NP_289741.1 CDS rpsO NC_002655.2 4121128 4121397 R primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 complement(4121128..4121397) Escherichia coli O157:H7 str. EDL933 960736 NP_289742.1 CDS truB NC_002655.2 4121546 4122490 R catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B complement(4121546..4122490) Escherichia coli O157:H7 str. EDL933 960733 NP_289743.1 CDS rbfA NC_002655.2 4122490 4122891 R associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A complement(4122490..4122891) Escherichia coli O157:H7 str. EDL933 958611 NP_289744.1 CDS infB NC_002655.2 4123056 4125728 R Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 complement(4123056..4125728) Escherichia coli O157:H7 str. EDL933 958612 NP_289745.1 CDS nusA NC_002655.2 4125753 4127240 R modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA complement(4125753..4127240) Escherichia coli O157:H7 str. EDL933 958613 NP_289746.2 CDS yhbC NC_002655.2 4127268 4127720 R in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein complement(4127268..4127720) Escherichia coli O157:H7 str. EDL933 958614 NP_289747.1 CDS argG NC_002655.2 4128351 4129694 D catalyzes the formation of arginosuccinate from citrulline and aspartate in arginine biosynthesis; argininosuccinate synthase 4128351..4129694 Escherichia coli O157:H7 str. EDL933 958616 NP_289748.1 CDS yhbX NC_002655.2 4129702 4131345 R alkaline phosphatase complement(4129702..4131345) Escherichia coli O157:H7 str. EDL933 958617 NP_289749.1 CDS secG NC_002655.2 4131887 4132219 R preprotein translocase subunit SecG complement(4131887..4132219) Escherichia coli O157:H7 str. EDL933 958619 NP_289750.1 CDS glmM NC_002655.2 4132447 4133784 R catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase complement(4132447..4133784) Escherichia coli O157:H7 str. EDL933 958620 NP_289751.2 CDS folP NC_002655.2 4133777 4134625 R catalyzes the formation of dihydropteroate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate; dihydropteroate synthase complement(4133777..4134625) Escherichia coli O157:H7 str. EDL933 958621 NP_289752.1 CDS hflB NC_002655.2 4134715 4136649 R inner membrane metalloprotease; may be involved in degradation of aberrant cytoplasmic and membrane proteins; ATP-dependent metalloprotease complement(4134715..4136649) Escherichia coli O157:H7 str. EDL933 958622 NP_289753.1 CDS rrmJ NC_002655.2 4136749 4137378 R Specifically methylates the uridine in position 2552 of 23S rRNA in the fully assembled 50S ribosomal subunit; 23S rRNA methyltransferase complement(4136749..4137378) Escherichia coli O157:H7 str. EDL933 958623 NP_289754.1 CDS yhbY NC_002655.2 4137504 4137797 D RNA binding protein found associated to pre-50S subunit of the ribosome; role in ribosome assembly; necessary for optimal growth but not cell viability; RNA-binding protein YhbY 4137504..4137797 Escherichia coli O157:H7 str. EDL933 958624 NP_289755.2 CDS greA NC_002655.2 4137953 4138429 R necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA complement(4137953..4138429) Escherichia coli O157:H7 str. EDL933 958625 NP_289756.1 CDS dacB NC_002655.2 4138677 4140110 D penicillin binding protein 4; penicillin sensitive; catalyzes the formation of D-alanine from D-alanyl-D-alanine; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains; D-alanyl-D-alanine carboxypeptidase 4138677..4140110 Escherichia coli O157:H7 str. EDL933 961450 NP_289757.1 CDS obgE NC_002655.2 4140150 4141322 R essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE complement(4140150..4141322) Escherichia coli O157:H7 str. EDL933 959234 NP_289758.1 CDS yhbE NC_002655.2 4141338 4142303 R hypothetical protein complement(4141338..4142303) Escherichia coli O157:H7 str. EDL933 958626 NP_289759.1 CDS rpmA NC_002655.2 4142430 4142687 R involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 complement(4142430..4142687) Escherichia coli O157:H7 str. EDL933 958627 NP_289760.1 CDS rplU NC_002655.2 4142708 4143019 R 50S ribosomal protein L21 complement(4142708..4143019) Escherichia coli O157:H7 str. EDL933 958628 NP_289761.1 CDS ispB NC_002655.2 4143278 4144249 D octaprenyl diphosphate synthase 4143278..4144249 Escherichia coli O157:H7 str. EDL933 958629 NP_289762.1 CDS nlp NC_002655.2 4144478 4144756 D activator of maltose metabolism genes; DNA-binding transcriptional regulator Nlp 4144478..4144756 Escherichia coli O157:H7 str. EDL933 958630 NP_289763.1 CDS murA NC_002655.2 4144804 4146063 R adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase complement(4144804..4146063) Escherichia coli O157:H7 str. EDL933 958631 NP_289764.1 CDS yrbA NC_002655.2 4146118 4146387 R hypothetical protein complement(4146118..4146387) Escherichia coli O157:H7 str. EDL933 958632 NP_289765.1 CDS yrbB NC_002655.2 4146532 4146921 R hypothetical protein complement(4146532..4146921) Escherichia coli O157:H7 str. EDL933 958633 NP_289766.1 CDS yrbC NC_002655.2 4146825 4147460 R hypothetical protein complement(4146825..4147460) Escherichia coli O157:H7 str. EDL933 958634 NP_289767.1 CDS yrbD NC_002655.2 4147479 4148030 R hypothetical protein complement(4147479..4148030) Escherichia coli O157:H7 str. EDL933 958635 NP_289768.1 CDS yrbE NC_002655.2 4148035 4148817 R hypothetical protein complement(4148035..4148817) Escherichia coli O157:H7 str. EDL933 958636 NP_289769.1 CDS yrbF NC_002655.2 4148825 4149634 R ATP-binding subunit of a ABC toluene efflux transporter; ABC transporter ATP-binding protein complement(4148825..4149634) Escherichia coli O157:H7 str. EDL933 958637 NP_289770.1 CDS yrbG NC_002655.2 4149844 4150821 D YrbG; inner membrane protein involved in cell envelope integrity; sodium ion/calcium ion exchanger; in E. coli it is non essential for cell viability; member of the YRBG family of cation/Ca2+ exchangers; calcium/sodium:proton antiporter 4149844..4150821 Escherichia coli O157:H7 str. EDL933 957437 NP_289771.1 CDS yrbH NC_002655.2 4150835 4151821 D D-arabinose 5-phosphate isomerase 4150835..4151821 Escherichia coli O157:H7 str. EDL933 961401 NP_289772.1 CDS yrbI NC_002655.2 4151842 4152408 D forms homotetramers; catalyzes hydrolysis of KDO 8-P to KDO and inorganic phosphate; functions in lipopolysaccharide biosynthesis; 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase 4151842..4152408 Escherichia coli O157:H7 str. EDL933 958043 NP_289773.1 CDS yrbK NC_002655.2 4152405 4152980 D hypothetical protein 4152405..4152980 Escherichia coli O157:H7 str. EDL933 958638 NP_289774.1 CDS yhbN NC_002655.2 4152949 4153506 D LptA; periplasmic binding protein part of a ABC superfamily of uptake transporters; interacts with LptB protein, the ATP binding component of the uptake system; lipopolysaccharide transport periplasmic protein LptA 4152949..4153506 Escherichia coli O157:H7 str. EDL933 958639 NP_289775.1 CDS yhbG NC_002655.2 4153513 4154238 D ABC transporter ATP-binding protein 4153513..4154238 Escherichia coli O157:H7 str. EDL933 958640 NP_289776.1 CDS rpoN NC_002655.2 4154286 4155719 D sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma 54 factor is responsible for the expression of enzymes involved in nitrogen assimilation and metabolism; the rhizobia often have 2 copies of this sigma factor; in Rhizobium etli RpoN1 shown to be involved in the assimilation of several nitrogen and carbon sources during free-living aerobic growth and RpoN2 is involved in symbiotic nitrogen fixation; in Bradyrhizobium both RpoN1 and N2 are functional in free-living and symbiotic conditions, rpoN1 gene was regulated in response to oxygen; RNA polymerase factor sigma-54 4154286..4155719 Escherichia coli O157:H7 str. EDL933 958641 NP_289777.1 CDS yhbH NC_002655.2 4155742 4156029 D YhbH; resting ribosome-binding protein involved in ribosome stabilization and preservation in stationary phase; binds specifically 100S ribosomes (an inactive ribosome product of a 70S ribosome dimerization); seems to be involved in modulation of the sigma(54) (RpoN) activity for quorum sensing; sigma(54) modulation protein 4155742..4156029 Escherichia coli O157:H7 str. EDL933 958642 NP_289778.1 CDS ptsN NC_002655.2 4156147 4156638 D PTS system transporter subunit IIA-like nitrogen-regulatory protein PtsN 4156147..4156638 Escherichia coli O157:H7 str. EDL933 958643 NP_289779.1 CDS yhbJ NC_002655.2 4156684 4157538 D hypothetical protein 4156684..4157538 Escherichia coli O157:H7 str. EDL933 958645 NP_289780.1 CDS ptsO NC_002655.2 4157535 4157807 D phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr) 4157535..4157807 Escherichia coli O157:H7 str. EDL933 958646 NP_289781.1 CDS yrbL NC_002655.2 4158021 4158653 D hypothetical protein 4158021..4158653 Escherichia coli O157:H7 str. EDL933 958647 NP_289782.1 CDS mtgA NC_002655.2 4158650 4159378 R glycosyltransferase; polymerizes glycan strands in the peptidoglycan; monofunctional biosynthetic peptidoglycan transglycosylase complement(4158650..4159378) Escherichia coli O157:H7 str. EDL933 958648 NP_289783.1 CDS yhbL NC_002655.2 4159375 4160037 R isoprenoid biosynthesis protein with amidotransferase-like domain complement(4159375..4160037) Escherichia coli O157:H7 str. EDL933 958649 NP_289784.1 CDS arcB NC_002655.2 4160259 4162595 R sensor-regulator protein which regulates the expression of many genes in response to respiratory growth conditions including anaerobic repression of the arc modulon; hybrid sensory histidine kinase in two-component regulatory system with ArcA; aerobic respiration control sensor protein ArcB complement(4160259..4162595) Escherichia coli O157:H7 str. EDL933 958650 NP_289785.1 CDS yhcC NC_002655.2 4162691 4163620 R hypothetical protein complement(4162691..4163620) Escherichia coli O157:H7 str. EDL933 958652 NP_289786.1 CDS gltB NC_002655.2 4164201 4168754 D catalyzes the formation of glutamate from glutamine and alpha-ketoglutarate; glutamate synthase 4164201..4168754 Escherichia coli O157:H7 str. EDL933 958654 NP_289787.1 CDS gltD NC_002655.2 4168767 4170185 D glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate; glutamate synthase 4168767..4170185 Escherichia coli O157:H7 str. EDL933 958655 NP_289788.1 CDS yhcG NC_002655.2 4170369 4171418 D hypothetical protein 4170369..4171418 Escherichia coli O157:H7 str. EDL933 958656 NP_289789.1 CDS yhcH NC_002655.2 4171478 4171942 R hypothetical protein complement(4171478..4171942) Escherichia coli O157:H7 str. EDL933 958657 NP_289790.2 CDS yhcI NC_002655.2 4171939 4172814 R catalyzes the phosphorylation of the N-acetylmannosamine (ManNAc) liberated from N-acetyl-neuraminic acid by the nanA protein; N-acetylmannosamine kinase complement(4171939..4172814) Escherichia coli O157:H7 str. EDL933 958658 NP_289791.1 CDS yhcJ NC_002655.2 4172811 4173500 R Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase complement(4172811..4173500) Escherichia coli O157:H7 str. EDL933 958659 NP_289792.2 CDS nanT NC_002655.2 4173548 4175038 R sialic acid transporter complement(4173548..4175038) Escherichia coli O157:H7 str. EDL933 958661 NP_289793.1 CDS nanA NC_002655.2 4175147 4176040 R catalyzes the formation of pyruvate and N-acetylmannosamine from N-acetylneuraminic acid; N-acetylneuraminate lyase complement(4175147..4176040) Escherichia coli O157:H7 str. EDL933 958662 NP_289794.1 CDS yhcK NC_002655.2 4176162 4176953 R Transcriptional repressor of the nan operon that encodes proteins involved in sialic acid utilization; transcriptional regulator NanR complement(4176162..4176953) Escherichia coli O157:H7 str. EDL933 958663 NP_289795.1 CDS Z4585 NC_002655.2 4177333 4178697 D YhcL; uncharacterized member of the DcuC family of anaerobic dicarboxylate transporters; probable role in transport of carboxylates across the inner membrane from the periplasm; its encoding gene is not essential for growth and is probably cryptic; cryptic C4-dicarboxylate transporter DcuD 4177333..4178697 Escherichia coli O157:H7 str. EDL933 958665 NP_289796.1 CDS sspB NC_002655.2 4178732 4179229 R ClpXP protease specificity-enhancing factor complement(4178732..4179229) Escherichia coli O157:H7 str. EDL933 958666 NP_289797.1 CDS sspA NC_002655.2 4179235 4179873 R transcriptional activator; required for activation of bacteriophage P1 late promoter; induced by starvation; stringent starvation protein A complement(4179235..4179873) Escherichia coli O157:H7 str. EDL933 959207 NP_289798.1 CDS rpsI NC_002655.2 4180268 4180660 R forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 complement(4180268..4180660) Escherichia coli O157:H7 str. EDL933 958573 NP_289799.1 CDS rplM NC_002655.2 4180676 4181104 R in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 complement(4180676..4181104) Escherichia coli O157:H7 str. EDL933 959313 NP_289800.1 CDS yhcM NC_002655.2 4181323 4182450 R hypothetical protein complement(4181323..4182450) Escherichia coli O157:H7 str. EDL933 957298 NP_289801.1 CDS yhcB NC_002655.2 4182638 4183042 D cytochrome d ubiquinol oxidase subunit III 4182638..4183042 Escherichia coli O157:H7 str. EDL933 958667 NP_289802.1 CDS degQ NC_002655.2 4183196 4184563 D serine endoprotease 4183196..4184563 Escherichia coli O157:H7 str. EDL933 958668 NP_289803.1 CDS degS NC_002655.2 4184653 4185720 D serine endoprotease 4184653..4185720 Escherichia coli O157:H7 str. EDL933 958669 NP_289804.1 CDS mdh NC_002655.2 4185784 4186722 R oxidizes malate to oxaloacetate; malate dehydrogenase complement(4185784..4186722) Escherichia coli O157:H7 str. EDL933 958670 NP_289805.1 CDS argR NC_002655.2 4187157 4187627 D regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes; arginine repressor ArgR 4187157..4187627 Escherichia coli O157:H7 str. EDL933 958671 NP_289806.1 CDS yhcN NC_002655.2 4187941 4188255 D hypothetical protein 4187941..4188255 Escherichia coli O157:H7 str. EDL933 958673 NP_289807.1 CDS yhcO NC_002655.2 4188311 4188583 R hypothetical protein complement(4188311..4188583) Escherichia coli O157:H7 str. EDL933 958674 NP_289808.1 CDS yhcP NC_002655.2 4188676 4190643 R with AaeA forms an efflux pump whose substrates are p-hydroxybenzoic acid 6-hydroxy-2-naphthoic and 2-hydroxycinnamate; p-hydroxybenzoic acid efflux subunit AaeB complement(4188676..4190643) Escherichia coli O157:H7 str. EDL933 958675 NP_289809.1 CDS yhcQ NC_002655.2 4190649 4191578 R with AaeB forms an efflux pump whose substrates are p-hydroxybenzoic acid, 6-hydroxy-2-naphthoic and 2-hydroxycinnamate; p-hydroxybenzoic acid efflux subunit AaeA complement(4190649..4191578) Escherichia coli O157:H7 str. EDL933 958676 NP_289810.2 CDS yhcR NC_002655.2 4191586 4191789 R membrane protein AaeX; the gene is a member of the aaeXAB operon; hypothetical protein complement(4191586..4191789) Escherichia coli O157:H7 str. EDL933 958677 NP_289811.1 CDS qseA NC_002655.2 4191972 4192901 D QseA; DNA-binding transcriptional regulator 4191972..4192901 Escherichia coli O157:H7 str. EDL933 958678 NP_289812.1 CDS tldD NC_002655.2 4193035 4194480 R responsible for the proteolytic maturation of the E. coli pMccB17 plasmid-encoded microcin B17, an exported protein that targets the essential topoisomerase II DNA gyrase; degrades the E. coli plasmid F-encoded CcdA; protease TldD complement(4193035..4194480) Escherichia coli O157:H7 str. EDL933 958679 NP_289813.1 CDS Z4604 NC_002655.2 4194636 4198436 R hypothetical protein complement(4194636..4198436) Escherichia coli O157:H7 str. EDL933 958680 NP_289814.2 CDS cafA NC_002655.2 4198504 4199973 R involved in the processing of the 5'end of 16S rRNA; ribonuclease G complement(4198504..4199973) Escherichia coli O157:H7 str. EDL933 958681 NP_289815.1 CDS maf NC_002655.2 4199963 4200556 R Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein complement(4199963..4200556) Escherichia coli O157:H7 str. EDL933 958682 NP_289816.1 CDS mreD NC_002655.2 4200565 4201053 R part of cell wall structural complex MreBCD; transmembrane component; rod shape-determining protein MreD complement(4200565..4201053) Escherichia coli O157:H7 str. EDL933 958683 NP_289817.1 CDS mreC NC_002655.2 4201053 4202156 R in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall; rod shape-determining protein MreC complement(4201053..4202156) Escherichia coli O157:H7 str. EDL933 958684 NP_289818.2 CDS mreB NC_002655.2 4202222 4203265 R functions in MreBCD complex in some organisms; rod shape-determining protein MreB complement(4202222..4203265) Escherichia coli O157:H7 str. EDL933 958686 NP_289819.1 CDS yhdA NC_002655.2 4203570 4205510 R regulates the degradation of the small RNAs CsrB and CsrC; may function to targate RNase E to specific RNA molecules; regulatory protein CsrD complement(4203570..4205510) Escherichia coli O157:H7 str. EDL933 958688 NP_289820.1 CDS yhdH NC_002655.2 4205662 4206636 D dehydrogenase 4205662..4206636 Escherichia coli O157:H7 str. EDL933 958689 NP_289821.1 CDS Z4613 NC_002655.2 4206694 4206795 R hypothetical protein complement(4206694..4206795) Escherichia coli O157:H7 str. EDL933 958690 NP_289822.1 CDS Z4614 NC_002655.2 4206922 4207041 D hypothetical protein 4206922..4207041 Escherichia coli O157:H7 str. EDL933 958691 NP_289823.1 CDS accB NC_002655.2 4207614 4208084 D composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxyl carrier protein subunit 4207614..4208084 Escherichia coli O157:H7 str. EDL933 958692 NP_289824.1 CDS accC NC_002655.2 4208095 4209444 D an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxylase subunit 4208095..4209444 Escherichia coli O157:H7 str. EDL933 958693 NP_289825.1 CDS yhdT NC_002655.2 4209553 4209795 D hypothetical protein 4209553..4209795 Escherichia coli O157:H7 str. EDL933 958694 NP_289826.2 CDS panF NC_002655.2 4209785 4211236 D mediates high affinitiy panthothenate transport which is stimulated by the presence of sodium ions; member of SSS family of sodium/solute symporters; the imported panthothenate is phosphorylated by panthothenate kinase; sodium/panthothenate symporter 4209785..4211236 Escherichia coli O157:H7 str. EDL933 958695 NP_289827.1 CDS prmA NC_002655.2 4211248 4212129 D methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype; 50S ribosomal protein L11 methyltransferase 4211248..4212129 Escherichia coli O157:H7 str. EDL933 958696 NP_289828.1 CDS yhdG NC_002655.2 4212458 4213423 D tRNA-dihydrouridine synthase B 4212458..4213423 Escherichia coli O157:H7 str. EDL933 958697 NP_289829.1 CDS fis NC_002655.2 4213449 4213745 D Stimulates excision of phage lambda; affects Mu development; acts as an activator of rRNA and iRNA transcription; Fis family transcriptional regulator 4213449..4213745 Escherichia coli O157:H7 str. EDL933 958698 NP_289830.2 CDS yhdJ NC_002655.2 4213830 4214714 D methyltransferase 4213830..4214714 Escherichia coli O157:H7 str. EDL933 958699 NP_289831.1 CDS yhdU NC_002655.2 4214798 4214977 D hypothetical protein 4214798..4214977 Escherichia coli O157:H7 str. EDL933 958704 NP_289832.1 CDS envR NC_002655.2 4214980 4215642 R DNA-binding transcriptional regulator EnvR complement(4214980..4215642) Escherichia coli O157:H7 str. EDL933 958706 NP_289833.1 CDS acrE NC_002655.2 4216041 4217198 D transmembrane protein affects septum formation and cell membrane permeability 4216041..4217198 Escherichia coli O157:H7 str. EDL933 958709 NP_289834.1 CDS acrF_1 NC_002655.2 4217210 4219096 D hypothetical protein 4217210..4219096 Escherichia coli O157:H7 str. EDL933 958713 NP_289835.1 CDS acrF_2 NC_002655.2 4219127 4220359 D hypothetical protein 4219127..4220359 Escherichia coli O157:H7 str. EDL933 958537 NP_289836.1 CDS yhdV NC_002655.2 4220612 4220833 D hypothetical protein 4220612..4220833 Escherichia coli O157:H7 str. EDL933 958707 NP_289837.1 CDS yhdW NC_002655.2 4221372 4222289 D periplasmic binding transport protein 4221372..4222289 Escherichia coli O157:H7 str. EDL933 961457 NP_289838.1 CDS yhdX NC_002655.2 4222357 4223538 D transport system permease 4222357..4223538 Escherichia coli O157:H7 str. EDL933 958716 NP_289839.1 CDS yhdY NC_002655.2 4223545 4224651 D transport system permease 4223545..4224651 Escherichia coli O157:H7 str. EDL933 958703 NP_289840.1 CDS yhdZ NC_002655.2 4224659 4225417 D ABC transporter ATP-binding protein 4224659..4225417 Escherichia coli O157:H7 str. EDL933 958701 NP_289841.1 CDS Z4650 NC_002655.2 4231254 4232024 D transferase 4231254..4232024 Escherichia coli O157:H7 str. EDL933 958731 NP_289842.1 CDS yrdB NC_002655.2 4232000 4232257 R hypothetical protein complement(4232000..4232257) Escherichia coli O157:H7 str. EDL933 961469 NP_289843.1 CDS aroE NC_002655.2 4232254 4233072 R AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase complement(4232254..4233072) Escherichia coli O157:H7 str. EDL933 958734 NP_289844.1 CDS yrdC NC_002655.2 4233077 4233649 R RimN; YrdC; required for maturation of 16s RNA; binds preferentially double stranded RNA; ribosome maturation factor complement(4233077..4233649) Escherichia coli O157:H7 str. EDL933 958732 NP_289845.1 CDS yrdD NC_002655.2 4233654 4234172 R DNA topoisomerase complement(4233654..4234172) Escherichia coli O157:H7 str. EDL933 959325 NP_289846.1 CDS smg NC_002655.2 4234225 4234698 R hypothetical protein complement(4234225..4234698) Escherichia coli O157:H7 str. EDL933 957231 NP_289847.1 CDS smf NC_002655.2 4234670 4235794 R DNA protecting protein DprA complement(4234670..4235794) Escherichia coli O157:H7 str. EDL933 958737 NP_289848.1 CDS def NC_002655.2 4235924 4236433 D cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 4235924..4236433 Escherichia coli O157:H7 str. EDL933 961473 NP_289849.1 CDS fmt NC_002655.2 4236448 4237395 D modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase 4236448..4237395 Escherichia coli O157:H7 str. EDL933 958738 NP_289850.1 CDS sun NC_002655.2 4237441 4238730 D catalyzes the methylation of cytosine at position 967 (m5C967) of 16S rRNA; SAM-dependent methyltransferase; 16S rRNA methyltransferase GidB 4237441..4238730 Escherichia coli O157:H7 str. EDL933 958740 NP_289851.1 CDS trkA NC_002655.2 4238752 4240128 D involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain; potassium transporter peripheral membrane protein 4238752..4240128 Escherichia coli O157:H7 str. EDL933 961474 NP_289852.1 CDS mscL NC_002655.2 4240258 4240668 D forms homopentamer; channel that opens in response to pressure or hypoosmotic shock; large-conductance mechanosensitive channel 4240258..4240668 Escherichia coli O157:H7 str. EDL933 958756 NP_289853.2 CDS zntR NC_002655.2 4240939 4241364 R mediates expression of the zinc export protein ZntA in response to high levels of zinc; member of MerR family of transcriptional regulators; zinc-responsive transcriptional regulator complement(4240939..4241364) Escherichia coli O157:H7 str. EDL933 958746 NP_289854.1 CDS yhdN NC_002655.2 4241375 4241743 R hypothetical protein complement(4241375..4241743) Escherichia coli O157:H7 str. EDL933 961494 NP_289855.1 CDS rplQ NC_002655.2 4241850 4242233 R is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 complement(4241850..4242233) Escherichia coli O157:H7 str. EDL933 958759 NP_289856.1 CDS rpoA NC_002655.2 4242274 4243263 R catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha complement(4242274..4243263) Escherichia coli O157:H7 str. EDL933 958748 NP_289857.1 CDS rpsD NC_002655.2 4243289 4243909 R primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 complement(4243289..4243909) Escherichia coli O157:H7 str. EDL933 961480 NP_289858.1 CDS rpsK NC_002655.2 4243943 4244332 R located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 complement(4243943..4244332) Escherichia coli O157:H7 str. EDL933 958770 NP_289859.1 CDS rpsM NC_002655.2 4244349 4244705 R located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 complement(4244349..4244705) Escherichia coli O157:H7 str. EDL933 961491 NP_289860.1 CDS rpmJ NC_002655.2 4244852 4244968 R smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif; 50S ribosomal protein L36 complement(4244852..4244968) Escherichia coli O157:H7 str. EDL933 958730 NP_289861.1 CDS secY NC_002655.2 4245000 4246331 R forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY complement(4245000..4246331) Escherichia coli O157:H7 str. EDL933 958757 NP_289862.1 CDS rplO NC_002655.2 4246339 4246773 R late assembly protein; 50S ribosomal protein L15 complement(4246339..4246773) Escherichia coli O157:H7 str. EDL933 961484 NP_289863.1 CDS rpmD NC_002655.2 4246777 4246956 R L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 complement(4246777..4246956) Escherichia coli O157:H7 str. EDL933 958758 NP_289864.1 CDS rpsE NC_002655.2 4246960 4247463 R located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 complement(4246960..4247463) Escherichia coli O157:H7 str. EDL933 961486 NP_289865.1 CDS rplR NC_002655.2 4247478 4247831 R binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 complement(4247478..4247831) Escherichia coli O157:H7 str. EDL933 958760 NP_289866.1 CDS rplF NC_002655.2 4247841 4248374 R ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 complement(4247841..4248374) Escherichia coli O157:H7 str. EDL933 958750 NP_289867.1 CDS rpsH NC_002655.2 4248387 4248779 R binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 complement(4248387..4248779) Escherichia coli O157:H7 str. EDL933 958728 NP_289868.1 CDS rpsN NC_002655.2 4248813 4249118 R located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 complement(4248813..4249118) Escherichia coli O157:H7 str. EDL933 958763 NP_289869.1 CDS rplE NC_002655.2 4249133 4249672 R part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 complement(4249133..4249672) Escherichia coli O157:H7 str. EDL933 958768 NP_289870.1 CDS rplX NC_002655.2 4249687 4250001 R assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 complement(4249687..4250001) Escherichia coli O157:H7 str. EDL933 961490 NP_289871.1 CDS rplN NC_002655.2 4250012 4250383 R binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 complement(4250012..4250383) Escherichia coli O157:H7 str. EDL933 958775 NP_289872.1 CDS rpsQ NC_002655.2 4250548 4250802 R primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 complement(4250548..4250802) Escherichia coli O157:H7 str. EDL933 958773 NP_289873.1 CDS rpmC NC_002655.2 4250802 4250993 R one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 complement(4250802..4250993) Escherichia coli O157:H7 str. EDL933 961497 NP_289874.1 CDS rplP NC_002655.2 4250993 4251403 R located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 complement(4250993..4251403) Escherichia coli O157:H7 str. EDL933 958767 NP_289875.1 CDS rpsC NC_002655.2 4251416 4252117 R forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 complement(4251416..4252117) Escherichia coli O157:H7 str. EDL933 961493 NP_289876.1 CDS rplV NC_002655.2 4252135 4252467 R binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 complement(4252135..4252467) Escherichia coli O157:H7 str. EDL933 958554 NP_289877.1 CDS rpsS NC_002655.2 4252482 4252760 R protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 complement(4252482..4252760) Escherichia coli O157:H7 str. EDL933 958783 NP_289878.1 CDS rplB NC_002655.2 4252777 4253598 R one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 complement(4252777..4253598) Escherichia coli O157:H7 str. EDL933 961506 NP_289879.1 CDS rplW NC_002655.2 4253616 4253918 R binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 complement(4253616..4253918) Escherichia coli O157:H7 str. EDL933 958774 NP_289880.1 CDS rplD NC_002655.2 4253915 4254520 R L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 complement(4253915..4254520) Escherichia coli O157:H7 str. EDL933 961496 NP_289881.1 CDS rplC NC_002655.2 4254531 4255160 R binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 complement(4254531..4255160) Escherichia coli O157:H7 str. EDL933 961453 NP_289882.1 CDS rpsJ NC_002655.2 4255193 4255504 R NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 complement(4255193..4255504) Escherichia coli O157:H7 str. EDL933 958790 NP_289883.1 CDS hopD NC_002655.2 4255883 4256350 D leader peptidase 4255883..4256350 Escherichia coli O157:H7 str. EDL933 958791 NP_289884.1 CDS Z4695 NC_002655.2 4256347 4256823 R iron storage protein; bacterioferritin complement(4256347..4256823) Escherichia coli O157:H7 str. EDL933 958798 NP_289885.1 CDS yheA NC_002655.2 4256896 4257090 R bacterioferritin-associated ferredoxin complement(4256896..4257090) Escherichia coli O157:H7 str. EDL933 961512 NP_289886.1 CDS tuf NC_002655.2 4257273 4258457 R EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu complement(4257273..4258457) Escherichia coli O157:H7 str. EDL933 958801 NP_289887.1 CDS fusA NC_002655.2 4258528 4260642 R EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G complement(4258528..4260642) Escherichia coli O157:H7 str. EDL933 961515 NP_289888.1 CDS rpsG NC_002655.2 4260739 4261209 R binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 complement(4260739..4261209) Escherichia coli O157:H7 str. EDL933 958803 NP_289889.1 CDS rpsL NC_002655.2 4261306 4261680 R interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 complement(4261306..4261680) Escherichia coli O157:H7 str. EDL933 958802 NP_289890.1 CDS yheL NC_002655.2 4261806 4262093 R in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur transfer complex subunit TusB complement(4261806..4262093) Escherichia coli O157:H7 str. EDL933 961516 NP_289891.1 CDS yheM NC_002655.2 4262101 4262460 R in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur relay protein TusC complement(4262101..4262460) Escherichia coli O157:H7 str. EDL933 958811 NP_289892.1 CDS yheN NC_002655.2 4262460 4262846 R in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur transfer complex subunit TusD complement(4262460..4262846) Escherichia coli O157:H7 str. EDL933 961521 NP_289893.1 CDS yheO NC_002655.2 4262846 4263580 R hypothetical protein complement(4262846..4263580) Escherichia coli O157:H7 str. EDL933 958804 NP_289894.1 CDS fkpA NC_002655.2 4263735 4264547 R rotamase; FKBP-type peptidylprolyl isomerase complement(4263735..4264547) Escherichia coli O157:H7 str. EDL933 958444 NP_289895.1 CDS slyX NC_002655.2 4264768 4264986 D hypothetical protein 4264768..4264986 Escherichia coli O157:H7 str. EDL933 961315 NP_289896.1 CDS slyD NC_002655.2 4265035 4265625 R rotamase; FKBP-type peptidylprolyl isomerase complement(4265035..4265625) Escherichia coli O157:H7 str. EDL933 961279 NP_289897.1 CDS Z4708 NC_002655.2 4265720 4265920 R No significant matches; hypothetical protein complement(4265720..4265920) Escherichia coli O157:H7 str. EDL933 961297 NP_289898.1 CDS kefB NC_002655.2 4265957 4267735 R involved in potassium efflux; glutathione-regulated potassium-efflux system protein KefB complement(4265957..4267735) Escherichia coli O157:H7 str. EDL933 958813 NP_289899.1 CDS yheR NC_002655.2 4267735 4268289 R required for KefB activity; glutathione-regulated potassium-efflux system ancillary protein KefG complement(4267735..4268289) Escherichia coli O157:H7 str. EDL933 961522 NP_289900.1 CDS yheS NC_002655.2 4268417 4270330 D ABC transporter ATP-binding protein 4268417..4270330 Escherichia coli O157:H7 str. EDL933 958805 NP_289901.1 CDS yheT NC_002655.2 4270330 4271352 D hydrolase 4270330..4271352 Escherichia coli O157:H7 str. EDL933 958814 NP_289902.1 CDS yheU NC_002655.2 4271346 4271564 D hypothetical protein 4271346..4271564 Escherichia coli O157:H7 str. EDL933 958818 NP_289903.1 CDS prkB NC_002655.2 4271618 4272487 D phosphoribulokinase 4271618..4272487 Escherichia coli O157:H7 str. EDL933 958831 NP_289904.1 CDS yhfA NC_002655.2 4272542 4272946 R hypothetical protein complement(4272542..4272946) Escherichia coli O157:H7 str. EDL933 958807 NP_289905.1 CDS crp NC_002655.2 4273248 4273880 D complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons; cAMP-regulatory protein 4273248..4273880 Escherichia coli O157:H7 str. EDL933 958797 NP_289906.1 CDS yhfK NC_002655.2 4273931 4276021 D hypothetical protein 4273931..4276021 Escherichia coli O157:H7 str. EDL933 958823 NP_289907.1 CDS argD NC_002655.2 4276088 4277308 R DapATase; bifunctional enzyme that functions in arginine and lysine biosynthetic pathways; catalyzes the formation of N-acetyl-L-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine or N-succinyl-2-L-amino-6-oxoheptanedioate from 2-oxoglutarate and N-succinyl-L-2,6-diaminoheptanedioate; bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase complement(4276088..4277308) Escherichia coli O157:H7 str. EDL933 961532 NP_289908.1 CDS pabA NC_002655.2 4277394 4277957 R aminodeoxychorismate synthase subunit PabA; with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis; PabA provides the glutamine amidotransferase activity; para-aminobenzoate synthase component II complement(4277394..4277957) Escherichia coli O157:H7 str. EDL933 958824 NP_289909.1 CDS fic NC_002655.2 4277989 4278591 R cell filamentation protein Fic complement(4277989..4278591) Escherichia coli O157:H7 str. EDL933 961531 NP_289910.1 CDS yhfG NC_002655.2 4278581 4278748 R hypothetical protein complement(4278581..4278748) Escherichia coli O157:H7 str. EDL933 958827 NP_289911.1 CDS ppiA NC_002655.2 4278853 4279425 R peptidyl-prolyl cis-trans isomerase A complement(4278853..4279425) Escherichia coli O157:H7 str. EDL933 961533 NP_289912.1 CDS yhfC NC_002655.2 4279696 4280877 D hypothetical protein 4279696..4280877 Escherichia coli O157:H7 str. EDL933 958828 NP_289913.1 CDS nirB NC_002655.2 4281139 4283682 D nitrite reductase (NAD(P)H) subunit 4281139..4283682 Escherichia coli O157:H7 str. EDL933 961534 NP_289914.1 CDS nirD NC_002655.2 4283679 4284005 D involved in reducing nitrite to ammonium to detoxify nitrite accumulation in anaerobic nitrate-respiring cells and regenerate NAD+; bounds to NirB, the cytoplasmic subunit, whose expression is induced at high nitrate concentrations; nitrite reductase small subunit 4283679..4284005 Escherichia coli O157:H7 str. EDL933 958830 NP_289915.1 CDS nirC NC_002655.2 4284131 4284937 D member of the FNT family of formate and nitrite transporters; nitrite transporter NirC 4284131..4284937 Escherichia coli O157:H7 str. EDL933 959621 NP_289916.1 CDS cysG NC_002655.2 4284956 4286329 D multifunction enzyme consisting of uroporphyrin-III C-methyltransferase, precorrin-2 dehydrogenase and sirohydrochlorin ferrochelatase; catalyzes the methylation of uroporphyrinogen III to form precorrin-2, then catalyzes formation of sirohydrochlorin from precorrin-2 and finally catalyzed the formation of siroheme from sirohydrochlorin; siroheme synthase 4284956..4286329 Escherichia coli O157:H7 str. EDL933 961541 NP_289917.1 CDS yhfL NC_002655.2 4286584 4286751 D hypothetical protein 4286584..4286751 Escherichia coli O157:H7 str. EDL933 958832 NP_289918.1 CDS frlA NC_002655.2 4286996 4288384 D inner membrane protein possibly involved in fructoselysine transport; member of the flr operon; fructoselysine transporter 4286996..4288384 Escherichia coli O157:H7 str. EDL933 961536 NP_289919.1 CDS frlB NC_002655.2 4288384 4289427 D catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine; fructoselysine-6-P-deglycase 4288384..4289427 Escherichia coli O157:H7 str. EDL933 958541 NP_289920.1 CDS Z4733 NC_002655.2 4289478 4290305 D YhfOP; YhfP; YhfO; FrlC; catalyzes the interconversion of fructoselysine and psicoselysine; fructoselysine 3-epimerase 4289478..4290305 Escherichia coli O157:H7 str. EDL933 958833 NP_289921.1 CDS Z4734m NC_002655.2 4290302 4291090 D fructoselysine 6-kinase 4290302..4291090 Escherichia coli O157:H7 str. EDL933 959642 NP_289922.1 CDS yhfR NC_002655.2 4291124 4291921 D may act as a transcriptional regulator of a fructoselysine-induced operon containing the yhfM, yhfN, yhfO, yhfP, yhfQ, and yhfR genes; DNA-binding transcriptional regulator FrlR 4291124..4291921 Escherichia coli O157:H7 str. EDL933 961538 NP_289923.1 CDS trpS NC_002655.2 4292052 4293056 R catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase complement(4292052..4293056) Escherichia coli O157:H7 str. EDL933 958834 NP_289924.1 CDS gph NC_002655.2 4293049 4293807 R catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate; phosphoglycolate phosphatase complement(4293049..4293807) Escherichia coli O157:H7 str. EDL933 958842 NP_289925.1 CDS rpe NC_002655.2 4293800 4294477 R catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate; ribulose-phosphate 3-epimerase complement(4293800..4294477) Escherichia coli O157:H7 str. EDL933 961547 NP_289926.1 CDS dam NC_002655.2 4294495 4295331 R DNA adenine methylase complement(4294495..4295331) Escherichia coli O157:H7 str. EDL933 958843 NP_289927.1 CDS damX NC_002655.2 4295438 4296724 R hypothetical protein complement(4295438..4296724) Escherichia coli O157:H7 str. EDL933 961560 NP_289928.1 CDS aroB NC_002655.2 4296816 4297904 R catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase complement(4296816..4297904) Escherichia coli O157:H7 str. EDL933 958849 NP_289929.2 CDS aroK NC_002655.2 4297961 4298482 R type I enzyme similar to type II but differentially regulated; major shikimate kinase in fully repressed cells; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase I complement(4297961..4298482) Escherichia coli O157:H7 str. EDL933 961553 NP_289930.1 CDS hofQ NC_002655.2 4298883 4300121 R outer membrane porin probably involved in uptake of extracellular double-stranded DNA; similar to outer membrane competence protein ComE from Haemophilus influenzae and outer membrane protein PilQ involved in type IV pilus production from Pseudomonas aeruginosa; porin complement(4298883..4300121) Escherichia coli O157:H7 str. EDL933 958855 NP_289931.1 CDS yrfA NC_002655.2 4300033 4300476 R hypothetical protein complement(4300033..4300476) Escherichia coli O157:H7 str. EDL933 958856 NP_289932.1 CDS yrfB NC_002655.2 4300427 4300867 R hypothetical protein complement(4300427..4300867) Escherichia coli O157:H7 str. EDL933 958865 NP_289933.1 CDS yrfC NC_002655.2 4300851 4301390 R hypothetical protein complement(4300851..4301390) Escherichia coli O157:H7 str. EDL933 958839 NP_289934.1 CDS yrfD NC_002655.2 4301374 4302195 R hypothetical protein complement(4301374..4302195) Escherichia coli O157:H7 str. EDL933 958826 NP_289935.2 CDS mrcA NC_002655.2 4302288 4304840 D bifunctional murein transglycosylase/murein transpeptidase; penicillin-binding protein 1A; involved in the synthesis of cross-linked peptidoglycan from the lipid intermediates in cell wall formation; penicillin-insensitive transglycosylase catalyzes the formation of linear glycan strands and the penicillin-sensitive transpeptidase catalyzes the cross-linking of the peptide subunits; peptidoglycan synthetase 4302288..4304840 Escherichia coli O157:H7 str. EDL933 958881 NP_289936.1 CDS nudE NC_002655.2 4305005 4305565 R ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose; ADP-ribose diphosphatase NudE complement(4305005..4305565) Escherichia coli O157:H7 str. EDL933 958125 NP_289937.1 CDS yrfF NC_002655.2 4305885 4308020 D dehydrogenase 4305885..4308020 Escherichia coli O157:H7 str. EDL933 959306 NP_289938.1 CDS yrfG NC_002655.2 4308040 4308753 D phosphatase 4308040..4308753 Escherichia coli O157:H7 str. EDL933 960875 NP_289939.1 CDS yrfH NC_002655.2 4308764 4309165 D ribosome-associated heat shock protein Hsp15 4308764..4309165 Escherichia coli O157:H7 str. EDL933 960872 NP_289940.2 CDS hslO NC_002655.2 4309190 4310068 D becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers; heat shock protein 33 4309190..4310068 Escherichia coli O157:H7 str. EDL933 958884 NP_289941.1 CDS yhgE NC_002655.2 4310131 4311855 R transport complement(4310131..4311855) Escherichia coli O157:H7 str. EDL933 961582 NP_289942.1 CDS Z4757 NC_002655.2 4311931 4312062 R No significant matches; hypothetical protein complement(4311931..4312062) Escherichia coli O157:H7 str. EDL933 958888 NP_289943.1 CDS pckA NC_002655.2 4312234 4313856 D PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP; phosphoenolpyruvate carboxykinase 4312234..4313856 Escherichia coli O157:H7 str. EDL933 958885 NP_289944.1 CDS envZ NC_002655.2 4313932 4315284 R membrane-localized osmosensor; histidine kinase; in high osmolarity EnvZ autophosphorylates itself and transfers phosphoryl group to OmpR; osmolarity sensor protein complement(4313932..4315284) Escherichia coli O157:H7 str. EDL933 959479 NP_289945.1 CDS ompR NC_002655.2 4315281 4316000 R part of two-component system EnvZ/OmpR; regulates transcription of outer membrane porin genes ompC/F; under high osmolarity EnvZ functions as kinase/phosphotransferase and phosphorylates OmpR; the result is increased expression of ompC and repression of ompF; also functions in regulation of other genes; forms dimers upon phosphorylation; osmolarity response regulator complement(4315281..4316000) Escherichia coli O157:H7 str. EDL933 957766 NP_289946.2 CDS greB NC_002655.2 4316228 4316704 D necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreB 4316228..4316704 Escherichia coli O157:H7 str. EDL933 958110 NP_289947.1 CDS yhgF NC_002655.2 4316900 4319122 D hypothetical protein 4316900..4319122 Escherichia coli O157:H7 str. EDL933 958889 NP_289948.1 CDS feoA NC_002655.2 4319560 4319787 D ferrous iron transport protein A 4319560..4319787 Escherichia coli O157:H7 str. EDL933 957589 NP_289949.1 CDS feoB NC_002655.2 4319804 4322125 D cytoplasmic membrane ferrous uptake system permease; mutations disrupt the ability of Escherichia coli to take up ferrous iron; GTP-binding protein which requires GTP for efficient iron(II) uptake; ferrous iron transport protein B 4319804..4322125 Escherichia coli O157:H7 str. EDL933 957596 NP_289950.1 CDS yhgG NC_002655.2 4322125 4322361 D hypothetical protein 4322125..4322361 Escherichia coli O157:H7 str. EDL933 958890 NP_289951.1 CDS yhgA NC_002655.2 4322564 4323442 D hypothetical protein 4322564..4323442 Escherichia coli O157:H7 str. EDL933 961581 NP_289952.1 CDS bioH NC_002655.2 4323469 4324239 R Shows carboxylesterase activity with a preference for short chain fatty acid esters; involved in pimeloyl-CoA synthesis; carboxylesterase BioH complement(4323469..4324239) Escherichia coli O157:H7 str. EDL933 958896 NP_289953.2 CDS yhgH NC_002655.2 4324277 4324960 D involved in high-affinity gluconate transport; gluconate periplasmic binding protein 4324277..4324960 Escherichia coli O157:H7 str. EDL933 958897 NP_289954.1 CDS yhgI NC_002655.2 4325019 4325594 D cytoplasmic protein that may be involved in the utilization of double-stranded DNA as a carbon source; DNA uptake protein 4325019..4325594 Escherichia coli O157:H7 str. EDL933 961586 NP_289955.1 CDS gntT NC_002655.2 4325955 4327271 D high-affinity transport of gluconate / gluconate permease 4325955..4327271 Escherichia coli O157:H7 str. EDL933 958902 NP_289956.1 CDS malQ NC_002655.2 4327316 4329400 R amylomaltase; acts to release glucose from maltodextrins; 4-alpha-glucanotransferase complement(4327316..4329400) Escherichia coli O157:H7 str. EDL933 961590 NP_289957.1 CDS malP NC_002655.2 4329410 4331803 R maltodextrin phosphorylase complement(4329410..4331803) Escherichia coli O157:H7 str. EDL933 958898 NP_289958.1 CDS Z4773 NC_002655.2 4332063 4332164 R No significant matches; hypothetical protein complement(4332063..4332164) Escherichia coli O157:H7 str. EDL933 961589 NP_289959.1 CDS malT NC_002655.2 4332415 4335120 D Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides; transcriptional regulator MalT 4332415..4335120 Escherichia coli O157:H7 str. EDL933 958900 NP_289960.1 CDS Z4775 NC_002655.2 4335117 4335245 D No significant matches; hypothetical protein 4335117..4335245 Escherichia coli O157:H7 str. EDL933 958906 NP_289961.1 CDS Z4776 NC_002655.2 4335181 4335465 D hypothetical protein 4335181..4335465 Escherichia coli O157:H7 str. EDL933 958926 NP_289962.1 CDS Z4777 NC_002655.2 4335456 4335941 D hypothetical protein 4335456..4335941 Escherichia coli O157:H7 str. EDL933 961606 NP_289963.1 CDS Z4778 NC_002655.2 4335991 4337019 R catalyzes the conversion of terminal3'-phosphate of RNA to the 2',3'-cyclicphosphodiester; RNA 3'-terminal-phosphate cyclase complement(4335991..4337019) Escherichia coli O157:H7 str. EDL933 958908 NP_289964.1 CDS rtcB NC_002655.2 4337023 4338249 R hypothetical protein complement(4337023..4338249) Escherichia coli O157:H7 str. EDL933 961595 NP_289965.1 CDS rtcR NC_002655.2 4338437 4340035 D 2-component regulator 4338437..4340035 Escherichia coli O157:H7 str. EDL933 958909 NP_289966.1 CDS glpR NC_002655.2 4340017 4340775 R represses the glpD, glpFK, glpTQ, and glpACB operons involved in glycerol-3-phosphate metabolism; DNA-binding transcriptional repressor GlpR complement(4340017..4340775) Escherichia coli O157:H7 str. EDL933 961600 NP_289967.1 CDS glpG NC_002655.2 4340792 4341622 R protease responsible for the cleavage between Ser and Asp residues of proteins in regions of high local hydrophilicity; intramembrane serine protease GlpG complement(4340792..4341622) Escherichia coli O157:H7 str. EDL933 958913 NP_289968.1 CDS glpE NC_002655.2 4341667 4341993 R belongs to rhodanese family; thiosulfate thiotransferase; in Escherichia coli this enzyme catalyzes the formation of thiocyanate from thiosulfate and cyanide with low efficiency; contains an active site cysteine; thiosulfate sulfurtransferase complement(4341667..4341993) Escherichia coli O157:H7 str. EDL933 961597 NP_289969.1 CDS glpD NC_002655.2 4342183 4343688 D in Escherichia coli this homodimeric enzyme is expressed under aerobic conditions; anaerobic expression is repressed by the arcAB system; converts sn-glycerol-3-phosphate and ubiquinone-8 to dihydroxy acetone phosphate and ubiquinol-8; associates with the cytoplasmic membrane; glycerol-3-phosphate dehydrogenase 4342183..4343688 Escherichia coli O157:H7 str. EDL933 958941 NP_289970.1 CDS Z4787 NC_002655.2 4343903 4344505 R No significant matches; hypothetical protein complement(4343903..4344505) Escherichia coli O157:H7 str. EDL933 961625 NP_289971.1 CDS Z4788 NC_002655.2 4344505 4345497 R hypothetical protein complement(4344505..4345497) Escherichia coli O157:H7 str. EDL933 958875 NP_289972.1 CDS Z4789 NC_002655.2 4345523 4347031 R hypothetical protein complement(4345523..4347031) Escherichia coli O157:H7 str. EDL933 958892 NP_289973.1 CDS glgP NC_002655.2 4347156 4349603 R glycogen phosphorylase complement(4347156..4349603) Escherichia coli O157:H7 str. EDL933 961619 NP_289974.1 CDS glgA NC_002655.2 4349622 4351055 R catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose; glycogen synthase complement(4349622..4351055) Escherichia coli O157:H7 str. EDL933 958927 NP_289975.1 CDS glgC NC_002655.2 4351055 4352350 R catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase complement(4351055..4352350) Escherichia coli O157:H7 str. EDL933 961608 NP_289976.1 CDS glgX NC_002655.2 4352368 4354341 R catalyzes the hydrolysis of the alpha-1,6-glucosidic linkages in partially depolymerized glycogen; glycogen debranching protein complement(4352368..4354341) Escherichia coli O157:H7 str. EDL933 958928 NP_289977.1 CDS glgB NC_002655.2 4354338 4356524 R catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain; glycogen branching protein complement(4354338..4356524) Escherichia coli O157:H7 str. EDL933 961611 NP_289978.1 CDS asd NC_002655.2 4356797 4357900 R catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase complement(4356797..4357900) Escherichia coli O157:H7 str. EDL933 958911 NP_289979.1 CDS yhgN NC_002655.2 4358092 4358685 D YhgN; Ec0197; hydrolyzes nucleoside triphosphates with an O6 atom-containing purine base to nucleoside monophosphate and pyrophosphate; seems to play a role in the elimination of aberrant purine-derived nucleotides containing the 6-keto group; shows preference for deoxyinosine triphosphate and xanthosine triphosphate over standard nucleoside triphosphates (dATP, dCTP, dGTP, and dTTP); dITP- and XTP- hydrolase 4358092..4358685 Escherichia coli O157:H7 str. EDL933 961596 NP_289980.1 CDS Z4799 NC_002655.2 4358731 4360026 R DNA processing protein complement(4358731..4360026) Escherichia coli O157:H7 str. EDL933 961622 NP_289981.1 CDS Z4801 NC_002655.2 4360085 4361059 R ATP-dependent DNA helicase complement(4360085..4361059) Escherichia coli O157:H7 str. EDL933 958957 NP_289982.1 CDS Z4802 NC_002655.2 4361063 4361452 R ATP-dependent DNA helicase complement(4361063..4361452) Escherichia coli O157:H7 str. EDL933 961639 NP_289983.1 CDS Z4803 NC_002655.2 4361449 4362057 R ATP-dependent DNA helicase complement(4361449..4362057) Escherichia coli O157:H7 str. EDL933 958942 NP_289984.1 CDS gntU NC_002655.2 4362197 4363537 R low affinity gluconate transporter complement(4362197..4363537) Escherichia coli O157:H7 str. EDL933 961623 NP_289985.2 CDS gntK NC_002655.2 4363541 4364068 R thermoresistant; catalyzes the formation of 6-phospho-D-gluconate from gluconate; gluconate kinase complement(4363541..4364068) Escherichia coli O157:H7 str. EDL933 958944 NP_289986.1 CDS gntR NC_002655.2 4364207 4365172 R gluconate (gnt) operon regulator complement(4364207..4365172) Escherichia coli O157:H7 str. EDL933 958943 NP_289987.1 CDS yhhW NC_002655.2 4365426 4366121 R hypothetical protein complement(4365426..4366121) Escherichia coli O157:H7 str. EDL933 958953 NP_289988.1 CDS yhhX NC_002655.2 4366244 4367281 R dehydrogenase complement(4366244..4367281) Escherichia coli O157:H7 str. EDL933 958972 NP_289989.1 CDS yhhY NC_002655.2 4367627 4368103 D YhhY; regulated by the fur regulator; unknown function; acetyltransferase YhhY 4367627..4368103 Escherichia coli O157:H7 str. EDL933 958937 NP_289990.1 CDS Z4810 NC_002655.2 4368314 4369225 D No significant matches; hypothetical protein 4368314..4369225 Escherichia coli O157:H7 str. EDL933 961627 NP_289991.1 CDS Z4811 NC_002655.2 4369174 4369590 R No significant matches; hypothetical protein complement(4369174..4369590) Escherichia coli O157:H7 str. EDL933 958938 NP_289992.1 CDS ggt NC_002655.2 4369960 4371705 R periplasmic enzyme; post-translationally processed into two subunits which are required for wild-type enzyme activity; cleaves the gammaglutamyl linkages of compounds such as glutathione and transfer the gammaglutamyl group to other amino acids and peptides; gamma-glutamyltranspeptidase complement(4369960..4371705) Escherichia coli O157:H7 str. EDL933 961624 NP_289993.1 CDS yhhA NC_002655.2 4371825 4372265 D hypothetical protein 4371825..4372265 Escherichia coli O157:H7 str. EDL933 958946 NP_289994.1 CDS ugpQ NC_002655.2 4372252 4372995 R hydrolyzes diesters during transport at the inner face of the cytoplasmic membrane to glycerol-3-phosphate and alcohol; induced when cells are starved for inorganic phosphate; glycerophosphodiester phosphodiesterase complement(4372252..4372995) Escherichia coli O157:H7 str. EDL933 961626 NP_289995.2 CDS ugpC NC_002655.2 4372992 4374062 R part of the UgpABCE glycerol-3-phosphate uptake system; glycerol-3-phosphate transporter ATP-binding subunit complement(4372992..4374062) Escherichia coli O157:H7 str. EDL933 958956 NP_289996.1 CDS ugpE NC_002655.2 4374064 4374909 R with UgpABC is involved in uptake of glycerol-3-phosphate; glycerol-3-phosphate transporter membrane protein complement(4374064..4374909) Escherichia coli O157:H7 str. EDL933 961635 NP_289997.1 CDS ugpA NC_002655.2 4374906 4375793 R with UgpEC is involved in the uptake of glycerol-3-phosphate; glycerol-3-phosphate transporter permease complement(4374906..4375793) Escherichia coli O157:H7 str. EDL933 958958 NP_289998.1 CDS ugpB NC_002655.2 4375892 4377208 R with UgpACE is involved in the uptake of glycerol-3-phosphate; glycerol-3-phosphate transporter periplasmic binding protein complement(4375892..4377208) Escherichia coli O157:H7 str. EDL933 961433 NP_289999.1 CDS Z4823 NC_002655.2 4377568 4378314 R No significant matches; hypothetical protein complement(4377568..4378314) Escherichia coli O157:H7 str. EDL933 961431 NP_290000.2 CDS livF NC_002655.2 4378433 4379146 R with LivGHMJ and LivGHMK is part of the high-affinity branched-chain amino acid transport system; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine; leucine/isoleucine/valine transporter ATP-binding subunit complement(4378433..4379146) Escherichia coli O157:H7 str. EDL933 961424 NP_290001.1 CDS livG NC_002655.2 4379148 4379915 R Part of the ABC transporter complexes LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine; leucine/isoleucine/valine transporter ATP-binding subunit complement(4379148..4379915) Escherichia coli O157:H7 str. EDL933 961419 NP_290002.1 CDS livM NC_002655.2 4379912 4381189 R Part of the ABC transporter complex LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine; leucine/isoleucine/valine transporter permease subunit complement(4379912..4381189) Escherichia coli O157:H7 str. EDL933 961384 NP_290003.1 CDS livH NC_002655.2 4381186 4382112 R LivHMGF is the membrane component of the LIV-I/LS branched-chain amino acid transporter; branched-chain amino acid ABC transporter permease complement(4381186..4382112) Escherichia coli O157:H7 str. EDL933 961373 NP_290004.1 CDS livK NC_002655.2 4382160 4383269 R high-affinity leucine-specific transport system; periplasmic binding protein complement(4382160..4383269) Escherichia coli O157:H7 str. EDL933 961368 NP_290005.1 CDS yhhK NC_002655.2 4383693 4384076 D hypothetical protein 4383693..4384076 Escherichia coli O157:H7 str. EDL933 961363 NP_290006.1 CDS Z4832 NC_002655.2 4384073 4384600 R hypothetical protein complement(4384073..4384600) Escherichia coli O157:H7 str. EDL933 961361 NP_290007.1 CDS Z4833 NC_002655.2 4384607 4384873 R hypothetical protein complement(4384607..4384873) Escherichia coli O157:H7 str. EDL933 961334 NP_290008.1 CDS livJ NC_002655.2 4385023 4386183 R high-affinity amino acid transport system; periplasmic binding protein complement(4385023..4386183) Escherichia coli O157:H7 str. EDL933 961332 NP_290009.1 CDS rpoH NC_002655.2 4386397 4387251 R binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters; RNA polymerase factor sigma-32 complement(4386397..4387251) Escherichia coli O157:H7 str. EDL933 961306 NP_290010.1 CDS ftsX NC_002655.2 4387496 4388554 R ABC transporter, membrane protein; cell division protein FtsX complement(4387496..4388554) Escherichia coli O157:H7 str. EDL933 961301 NP_290011.1 CDS ftsE NC_002655.2 4388547 4389215 R ATP-binding protein of an ATP-binding cassette transporter; when bound to FtsX, FtsEX localizes to the cell division site and plays a role in the assembly or stability of the septal ring under low-salt growth conditions; cell division protein FtsE complement(4388547..4389215) Escherichia coli O157:H7 str. EDL933 961298 NP_290012.1 CDS ftsY NC_002655.2 4389218 4390714 R signal recognition protein receptor; functions in the targeting and insertion of membrane proteins; cell division protein FtsY complement(4389218..4390714) Escherichia coli O157:H7 str. EDL933 961296 NP_290013.1 CDS rsmD NC_002655.2 4390864 4391460 D catalyzes the methylation of 16S rRNA at position G966; 16S rRNA m(2)G966-methyltransferase 4390864..4391460 Escherichia coli O157:H7 str. EDL933 961292 NP_290014.1 CDS yhhL NC_002655.2 4391450 4391719 D hypothetical protein 4391450..4391719 Escherichia coli O157:H7 str. EDL933 961289 NP_290015.1 CDS yhhM NC_002655.2 4391722 4392081 R receptor complement(4391722..4392081) Escherichia coli O157:H7 str. EDL933 961284 NP_290016.1 CDS yhhN NC_002655.2 4392222 4392848 D hypothetical protein 4392222..4392848 Escherichia coli O157:H7 str. EDL933 961270 NP_290017.1 CDS zntA NC_002655.2 4392922 4395120 D P-type ATPase involved in the export of lead, cadmium, zinc and mercury; zinc/cadmium/mercury/lead-transporting ATPase 4392922..4395120 Escherichia coli O157:H7 str. EDL933 961265 NP_290018.1 CDS yhhP NC_002655.2 4395222 4395467 R TusA; transfers sulfur to TusBCD complex; involved in thiouridation of U34 position of some tRNAs; sulfur transfer protein SirA complement(4395222..4395467) Escherichia coli O157:H7 str. EDL933 961264 NP_290019.1 CDS yhhQ NC_002655.2 4395688 4396353 D hypothetical protein 4395688..4396353 Escherichia coli O157:H7 str. EDL933 961263 NP_290020.2 CDS Z4846 NC_002655.2 4396426 4396983 D hypothetical protein 4396426..4396983 Escherichia coli O157:H7 str. EDL933 961260 NP_290021.2 CDS yhhS NC_002655.2 4396987 4398204 R major facilitator superfamily transporter complement(4396987..4398204) Escherichia coli O157:H7 str. EDL933 961258 NP_290022.1 CDS yhhT NC_002655.2 4398291 4399385 D hypothetical protein 4398291..4399385 Escherichia coli O157:H7 str. EDL933 961257 NP_290023.1 CDS Z4849 NC_002655.2 4399765 4400154 D No significant matches; hypothetical protein 4399765..4400154 Escherichia coli O157:H7 str. EDL933 961255 NP_290024.1 CDS Z4850 NC_002655.2 4400223 4401281 D O-methyltransferase 4400223..4401281 Escherichia coli O157:H7 str. EDL933 961254 NP_290025.1 CDS Z4851 NC_002655.2 4401322 4402044 D No significant matches; hypothetical protein 4401322..4402044 Escherichia coli O157:H7 str. EDL933 961253 NP_290026.1 CDS Z4852 NC_002655.2 4402041 4402862 D phospholipid biosynthesis acyltransferase 4402041..4402862 Escherichia coli O157:H7 str. EDL933 961252 NP_290027.1 CDS Z4853 NC_002655.2 4402837 4403094 D acyl carrier protein 4402837..4403094 Escherichia coli O157:H7 str. EDL933 961251 NP_290028.1 CDS Z4854 NC_002655.2 4403106 4403357 D carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 4403106..4403357 Escherichia coli O157:H7 str. EDL933 961250 NP_290029.1 CDS Z4855 NC_002655.2 4403362 4403943 D hypothetical protein 4403362..4403943 Escherichia coli O157:H7 str. EDL933 961249 NP_290030.1 CDS Z4856 NC_002655.2 4403940 4405301 D hypothetical protein 4403940..4405301 Escherichia coli O157:H7 str. EDL933 961248 NP_290031.1 CDS Z4857 NC_002655.2 4405288 4405641 D No significant matches; hypothetical protein 4405288..4405641 Escherichia coli O157:H7 str. EDL933 961247 NP_290032.1 CDS Z4858 NC_002655.2 4405632 4407308 D hypothetical protein 4405632..4407308 Escherichia coli O157:H7 str. EDL933 961246 NP_290033.1 CDS Z4859 NC_002655.2 4407312 4407734 D hypothetical protein 4407312..4407734 Escherichia coli O157:H7 str. EDL933 961245 NP_290034.1 CDS Z4860 NC_002655.2 4407731 4408336 D No significant matches; hypothetical protein 4407731..4408336 Escherichia coli O157:H7 str. EDL933 961244 NP_290035.1 CDS Z4861 NC_002655.2 4408305 4410623 D hypothetical protein 4408305..4410623 Escherichia coli O157:H7 str. EDL933 961243 NP_290036.1 CDS Z4862 NC_002655.2 4410620 4411204 D No significant matches; hypothetical protein 4410620..4411204 Escherichia coli O157:H7 str. EDL933 961242 NP_290037.1 CDS Z4863 NC_002655.2 4411206 4412375 D FabB; beta-ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase 4411206..4412375 Escherichia coli O157:H7 str. EDL933 961241 NP_290038.1 CDS Z4864 NC_002655.2 4412372 4412836 D hypothetical protein 4412372..4412836 Escherichia coli O157:H7 str. EDL933 961240 NP_290039.1 CDS fabG NC_002655.2 4412836 4413567 D Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 4412836..4413567 Escherichia coli O157:H7 str. EDL933 961239 NP_290040.1 CDS Z4866 NC_002655.2 4413564 4414793 D FabB; beta-ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase 4413564..4414793 Escherichia coli O157:H7 str. EDL933 961238 NP_290041.1 CDS Z4867 NC_002655.2 4414795 4415382 D holo-(acyl carrier protein) synthase 2 4414795..4415382 Escherichia coli O157:H7 str. EDL933 961237 NP_290042.1 CDS nikA NC_002655.2 4415493 4417067 D periplasmic binding protein for nickel 4415493..4417067 Escherichia coli O157:H7 str. EDL933 961236 NP_290043.1 CDS nikB NC_002655.2 4417067 4418011 D with NikACDE is involved in nickel transport into the cell; nickel transporter permease NikB 4417067..4418011 Escherichia coli O157:H7 str. EDL933 961235 NP_290044.1 CDS nikC NC_002655.2 4418008 4418841 D with NikABDE is involved in nickel transport into the cell; nickel transporter permease NikC 4418008..4418841 Escherichia coli O157:H7 str. EDL933 961234 NP_290045.1 CDS nikD NC_002655.2 4418841 4419605 D with NikABCE is involved in nickel transport into the cell; nickel transporter ATP-binding protein NikD 4418841..4419605 Escherichia coli O157:H7 str. EDL933 961233 NP_290046.1 CDS nikE NC_002655.2 4419602 4420408 D with NikABCD is involved with nickel transport into the cell; nickel transporter ATP-binding protein NikE 4419602..4420408 Escherichia coli O157:H7 str. EDL933 961232 NP_290047.1 CDS yhhG NC_002655.2 4420414 4420815 D Inhibits transcription at high concentrations of nickel; nickel responsive regulator 4420414..4420815 Escherichia coli O157:H7 str. EDL933 961231 NP_290048.1 CDS Z4874 NC_002655.2 4421005 4421760 D regulator 4421005..4421760 Escherichia coli O157:H7 str. EDL933 961229 NP_290049.1 CDS Z4875 NC_002655.2 4421785 4422258 D phosphotransferase system enzyme subunit 4421785..4422258 Escherichia coli O157:H7 str. EDL933 961228 NP_290050.1 CDS Z4876 NC_002655.2 4422255 4422536 D phosphotransferase system enzyme subunit 4422255..4422536 Escherichia coli O157:H7 str. EDL933 961227 NP_290051.1 CDS Z4877 NC_002655.2 4422583 4423971 D phosphotransferase system enzyme subunit 4422583..4423971 Escherichia coli O157:H7 str. EDL933 961226 NP_290052.1 CDS Z4878 NC_002655.2 4423964 4425472 D xylulose kinase 4423964..4425472 Escherichia coli O157:H7 str. EDL933 961225 NP_290053.1 CDS Z4879 NC_002655.2 4425462 4425731 D phosphocarrier protein 4425462..4425731 Escherichia coli O157:H7 str. EDL933 961223 NP_290054.1 CDS gatY NC_002655.2 4425764 4426624 D class II aldolase; catalyzes the reversible aldol condensation of dihydroxyacetonephosphate and glyceraldehyde 3-phosphate in the Calvin cycle, glycolysis and gluconeogenesis; fructose-1,6-bisphosphate aldolase 4425764..4426624 Escherichia coli O157:H7 str. EDL933 961222 NP_290055.1 CDS Z4882 NC_002655.2 4426674 4427033 R No significant matches; hypothetical protein complement(4426674..4427033) Escherichia coli O157:H7 str. EDL933 961220 NP_290056.1 CDS Z4883 NC_002655.2 4427030 4427305 R No significant matches; hypothetical protein complement(4427030..4427305) Escherichia coli O157:H7 str. EDL933 961218 NP_290057.1 CDS yhhJ NC_002655.2 4427378 4428505 R transporter complement(4427378..4428505) Escherichia coli O157:H7 str. EDL933 961216 NP_290058.1 CDS yhiH NC_002655.2 4428502 4431186 R ABC transporter ATP-binding protein, fragment 1 complement(4428502..4431186) Escherichia coli O157:H7 str. EDL933 961214 NP_290059.1 CDS yhiI NC_002655.2 4431234 4432301 R hypothetical protein complement(4431234..4432301) Escherichia coli O157:H7 str. EDL933 961213 NP_290060.1 CDS yhiJ NC_002655.2 4432667 4434289 R hypothetical protein complement(4432667..4434289) Escherichia coli O157:H7 str. EDL933 961212 NP_290061.1 CDS Z4888 NC_002655.2 4434551 4436224 R hypothetical protein complement(4434551..4436224) Escherichia coli O157:H7 str. EDL933 961211 NP_290062.1 CDS yhiM NC_002655.2 4436447 4437598 D hypothetical protein 4436447..4437598 Escherichia coli O157:H7 str. EDL933 961210 NP_290063.1 CDS yhiN NC_002655.2 4437916 4439118 R hypothetical protein complement(4437916..4439118) Escherichia coli O157:H7 str. EDL933 961209 NP_290064.1 CDS pitA NC_002655.2 4439351 4440850 D low-affinity phosphate transport protein 4439351..4440850 Escherichia coli O157:H7 str. EDL933 961208 NP_290065.1 CDS yhiO NC_002655.2 4440921 4441256 R ppGpp-dependent, membrane associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress; universal stress protein UspB complement(4440921..4441256) Escherichia coli O157:H7 str. EDL933 961207 NP_290066.1 CDS uspA NC_002655.2 4441648 4442082 D universal stress protein; broad regulatory function? 4441648..4442082 Escherichia coli O157:H7 str. EDL933 961205 NP_290067.1 CDS yhiP NC_002655.2 4442399 4443868 D member of the POT family of peptide transporters; probable proton-dependent peptide transporter function; inner membrane transporter YhiP 4442399..4443868 Escherichia coli O157:H7 str. EDL933 961204 NP_290068.1 CDS yhiQ NC_002655.2 4443917 4444669 R predicted SAM-dependent methyltransferase; methyltransferase complement(4443917..4444669) Escherichia coli O157:H7 str. EDL933 961201 NP_290069.1 CDS prlC NC_002655.2 4444677 4446719 R oligopeptidase A complement(4444677..4446719) Escherichia coli O157:H7 str. EDL933 961200 NP_290070.1 CDS yhiR NC_002655.2 4446922 4447764 D hypothetical protein 4446922..4447764 Escherichia coli O157:H7 str. EDL933 961199 NP_290071.1 CDS gor NC_002655.2 4447836 4449188 D catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense; glutathione reductase 4447836..4449188 Escherichia coli O157:H7 str. EDL933 961197 NP_290072.1 CDS arsR NC_002655.2 4450069 4450422 D regulates the expression of of the arsRBC involved in resistance to arsenic; ArsR family transcriptional regulator 4450069..4450422 Escherichia coli O157:H7 str. EDL933 961196 NP_290073.1 CDS arsB NC_002655.2 4450476 4451765 D arsenical pump membrane protein 4450476..4451765 Escherichia coli O157:H7 str. EDL933 961195 NP_290074.1 CDS arsC NC_002655.2 4451778 4452203 D arsenate reductase 4451778..4452203 Escherichia coli O157:H7 str. EDL933 961191 NP_290075.1 CDS Z4906 NC_002655.2 4452315 4452422 D No significant matches; hypothetical protein 4452315..4452422 Escherichia coli O157:H7 str. EDL933 961189 NP_290076.1 CDS Z4907 NC_002655.2 4452831 4453946 D hypothetical protein 4452831..4453946 Escherichia coli O157:H7 str. EDL933 961188 NP_290077.1 CDS slp NC_002655.2 4454268 4454867 D hypothetical protein 4454268..4454867 Escherichia coli O157:H7 str. EDL933 961185 NP_290078.1 CDS yhiF NC_002655.2 4455023 4455553 D hypothetical protein 4455023..4455553 Escherichia coli O157:H7 str. EDL933 961181 NP_290079.1 CDS chuS NC_002655.2 4455614 4456642 R heme/hemoglobin transport protein complement(4455614..4456642) Escherichia coli O157:H7 str. EDL933 961177 NP_290080.1 CDS chuA NC_002655.2 4456691 4458673 R outer membrane heme/hemoglobin receptor complement(4456691..4458673) Escherichia coli O157:H7 str. EDL933 961176 NP_290081.1 CDS Z4912 NC_002655.2 4458949 4459233 R No significant matches; hypothetical protein complement(4458949..4459233) Escherichia coli O157:H7 str. EDL933 961172 NP_290082.1 CDS chuT NC_002655.2 4459356 4460270 D periplasmic binding protein 4459356..4460270 Escherichia coli O157:H7 str. EDL933 961171 NP_290083.1 CDS chuW NC_002655.2 4460290 4461627 D catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 4460290..4461627 Escherichia coli O157:H7 str. EDL933 961167 NP_290084.1 CDS chuX NC_002655.2 4461640 4462134 D hypothetical protein 4461640..4462134 Escherichia coli O157:H7 str. EDL933 961164 NP_290085.1 CDS chuY NC_002655.2 4462134 4462757 D hypothetical protein 4462134..4462757 Escherichia coli O157:H7 str. EDL933 961163 NP_290086.1 CDS chuU NC_002655.2 4462806 4463798 D permease of iron compound ABC transport system 4462806..4463798 Escherichia coli O157:H7 str. EDL933 961162 NP_290087.1 CDS hmuV NC_002655.2 4463795 4464565 D with HmuTU is involved in the transport of hemin; hemin importer ATP-binding subunit 4463795..4464565 Escherichia coli O157:H7 str. EDL933 961161 NP_290088.1 CDS yhiD NC_002655.2 4464617 4465264 R inner membrane protein involved in cell density-dependent acid resistance; part of the acid fitness island (AFI) of E. coli; Mg(2+) transport ATPase complement(4464617..4465264) Escherichia coli O157:H7 str. EDL933 961160 NP_290089.1 CDS hdeB NC_002655.2 4465328 4465666 R acid-resistance protein complement(4465328..4465666) Escherichia coli O157:H7 str. EDL933 961159 NP_290090.1 CDS hdeA NC_002655.2 4465770 4466102 R inactive form; acid-resistance protein complement(4465770..4466102) Escherichia coli O157:H7 str. EDL933 961158 NP_290091.1 CDS hdeD NC_002655.2 4466357 4466929 D acid-resistance membrane protein 4466357..4466929 Escherichia coli O157:H7 str. EDL933 961157 NP_290092.1 CDS yhiE NC_002655.2 4467728 4468255 D hypothetical protein 4467728..4468255 Escherichia coli O157:H7 str. EDL933 961156 NP_290093.1 CDS yhiU NC_002655.2 4468594 4469751 D with MdtF and tolC is involved in resistance to rhodamine 6G, erythromycin, doxorubicin and other compounds; multidrug efflux system protein MdtE 4468594..4469751 Escherichia coli O157:H7 str. EDL933 961155 NP_290094.1 CDS yhiV NC_002655.2 4469776 4472889 D transport system permease 4469776..4472889 Escherichia coli O157:H7 str. EDL933 961153 NP_290095.1 CDS yhiW NC_002655.2 4473252 4473980 R AraC family transcriptional regulator complement(4473252..4473980) Escherichia coli O157:H7 str. EDL933 961148 NP_290096.1 CDS yhiX NC_002655.2 4474348 4475172 R regulates genes in response to acid and/or during stationary phase; DNA-binding transcriptional regulator GadX complement(4474348..4475172) Escherichia coli O157:H7 str. EDL933 961146 NP_290097.1 CDS gadA NC_002655.2 4475543 4476943 R glutamate decarboxylase complement(4475543..4476943) Escherichia coli O157:H7 str. EDL933 961141 NP_290098.1 CDS yhjA NC_002655.2 4477154 4478551 R cytochrome C peroxidase complement(4477154..4478551) Escherichia coli O157:H7 str. EDL933 961135 NP_290099.1 CDS treF NC_002655.2 4478956 4480605 D cytoplasmic; catalyzes the hydrolysis of trehalose to glucose; trehalase 4478956..4480605 Escherichia coli O157:H7 str. EDL933 961133 NP_290100.1 CDS yhjB NC_002655.2 4480656 4481258 R regulator complement(4480656..4481258) Escherichia coli O157:H7 str. EDL933 961122 NP_290101.1 CDS yhjC NC_002655.2 4481706 4482677 D LysR family transcriptional regulator 4481706..4482677 Escherichia coli O157:H7 str. EDL933 961121 NP_290102.1 CDS yhjD NC_002655.2 4482726 4483739 D hypothetical protein 4482726..4483739 Escherichia coli O157:H7 str. EDL933 961112 NP_290103.1 CDS yhjE NC_002655.2 4484151 4485473 D transporter 4484151..4485473 Escherichia coli O157:H7 str. EDL933 961102 NP_290104.1 CDS yhjG NC_002655.2 4485655 4487730 R hypothetical protein complement(4485655..4487730) Escherichia coli O157:H7 str. EDL933 961097 NP_290105.1 CDS yhjH NC_002655.2 4487785 4488552 R in Escherichia coli this protein is involved in flagellar function; diguanylate phosphodiesterase complement(4487785..4488552) Escherichia coli O157:H7 str. EDL933 961095 NP_290106.1 CDS kdgK NC_002655.2 4488565 4489713 D 2-dehydro-3-deoxygluconokinase 4488565..4489713 Escherichia coli O157:H7 str. EDL933 961094 NP_290107.1 CDS yhjJ NC_002655.2 4489809 4491305 R hypothetical protein complement(4489809..4491305) Escherichia coli O157:H7 str. EDL933 961093 NP_290108.1 CDS dctA NC_002655.2 4491526 4492812 R involved in the transport of C4-dicarboxylates across the membrane; C4-dicarboxylate transporter DctA complement(4491526..4492812) Escherichia coli O157:H7 str. EDL933 961092 NP_290109.1 CDS yhjK NC_002655.2 4492995 4494950 R HmsP in Yersinia pestis plays a role in invasion of epithelial cells; the EAL-domain portion of HmsP from Y. pestis shows phosphodiesterase activity which is required for the inhibition of biofilm formation; inner membrane protein; similar to a phosphodiesterase from E. coli; phosphodiesterase complement(4492995..4494950) Escherichia coli O157:H7 str. EDL933 961091 NP_290110.1 CDS yhjL NC_002655.2 4495065 4498528 R cellulose is produced by the multicellular morphotypes of E. coli and Salmonella typhimurium; the cellulose biosynthesis genes bcsA, bcsB, bcsZ and bcsC are constitutively transcribed, however, cellulose synthesis is dependent on the expression of adrA; cellulose synthase subunit BcsC complement(join(4495065..4498139,4498139..4498528)) Escherichia coli O157:H7 str. EDL933 959625 NP_290111.1 CDS yhjM NC_002655.2 4498510 4499616 R catalyzes the hydrolysis of 1,4-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; endo-1,4-D-glucanase complement(4498510..4499616) Escherichia coli O157:H7 str. EDL933 961090 NP_290112.2 CDS yhjN NC_002655.2 4499623 4501950 R binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP); cellulose synthase regulator protein complement(4499623..4501950) Escherichia coli O157:H7 str. EDL933 961088 NP_290113.2 CDS bcsA NC_002655.2 4501991 4504609 R polymerizes uridine 5'-diphosphate glucose to cellulose; acts with BcsB, BcsZ and BcsC in cellulose biosynthesis; cellulose synthase catalytic subunit complement(4501991..4504609) Escherichia coli O157:H7 str. EDL933 961086 NP_290114.1 CDS Z4950m NC_002655.2 4504606 4505358 R cell division protein complement(4504606..4505358) Escherichia coli O157:H7 str. EDL933 959641 NP_290115.1 CDS yhjR NC_002655.2 4505370 4505558 R hypothetical protein complement(4505370..4505558) Escherichia coli O157:H7 str. EDL933 961085 NP_290116.1 CDS yhjS NC_002655.2 4505831 4507402 D protease 4505831..4507402 Escherichia coli O157:H7 str. EDL933 961084 NP_290117.1 CDS yhjT NC_002655.2 4507402 4507590 D hypothetical protein 4507402..4507590 Escherichia coli O157:H7 str. EDL933 961083 NP_290118.1 CDS yhjU NC_002655.2 4507587 4509266 D hypothetical protein 4507587..4509266 Escherichia coli O157:H7 str. EDL933 961082 NP_290119.1 CDS Z4955 NC_002655.2 4509353 4509595 R No significant matches; hypothetical protein complement(4509353..4509595) Escherichia coli O157:H7 str. EDL933 961081 NP_290120.1 CDS yhjV NC_002655.2 4509936 4511207 D transporter protein 4509936..4511207 Escherichia coli O157:H7 str. EDL933 961080 NP_290121.1 CDS dppF NC_002655.2 4511237 4512241 R Part of the ABC transporter complex DppABCDF involved in the transport of dipeptides; dipeptide transporter ATP-binding subunit complement(4511237..4512241) Escherichia coli O157:H7 str. EDL933 961079 NP_290122.1 CDS dppD NC_002655.2 4512238 4513221 R DppD and DppF are the ATP-binding components of the ABC dipeptide transport system DppABCDF; dipeptide transporter ATP-binding subunit complement(4512238..4513221) Escherichia coli O157:H7 str. EDL933 961077 NP_290123.1 CDS dppC NC_002655.2 4513232 4514134 R dipeptide transporter complement(4513232..4514134) Escherichia coli O157:H7 str. EDL933 961076 NP_290124.1 CDS dppB NC_002655.2 4514144 4515163 R transports peptides consisting of two or three amino acids; dipeptide transporter permease DppB complement(4514144..4515163) Escherichia coli O157:H7 str. EDL933 961075 NP_290125.1 CDS dppA NC_002655.2 4515314 4516921 R dipeptide transport protein complement(4515314..4516921) Escherichia coli O157:H7 str. EDL933 961074 NP_290126.2 CDS yhjW NC_002655.2 4517834 4519525 R catalyzes the addition of a phosphoethanolamine group to the outer Kdo residue of lipopolysaccharide; phosphoethanolamine transferase complement(4517834..4519525) Escherichia coli O157:H7 str. EDL933 961072 NP_290127.1 CDS Z4965 NC_002655.2 4519782 4520312 R fimbrial subunit complement(4519782..4520312) Escherichia coli O157:H7 str. EDL933 961071 NP_290128.1 CDS Z4966 NC_002655.2 4520317 4521372 R fimbrial protein complement(4520317..4521372) Escherichia coli O157:H7 str. EDL933 961070 NP_290129.1 CDS Z4968m NC_002655.2 4521387 4523960 R PapC-like porin protein involved in fimbrial biogenesis complement(4521387..4523960) Escherichia coli O157:H7 str. EDL933 959640 NP_290130.1 CDS Z4969 NC_002655.2 4523989 4524687 R fimbrial chaperone complement(4523989..4524687) Escherichia coli O157:H7 str. EDL933 961069 NP_290131.1 CDS Z4971 NC_002655.2 4524740 4525276 R major fimbrial subunit complement(4524740..4525276) Escherichia coli O157:H7 str. EDL933 961068 NP_290132.1 CDS yhjX NC_002655.2 4525608 4526810 R resistance protein complement(4525608..4526810) Escherichia coli O157:H7 str. EDL933 961067 NP_290133.1 CDS yhjY NC_002655.2 4527039 4527743 R lipase complement(4527039..4527743) Escherichia coli O157:H7 str. EDL933 961065 NP_290134.1 CDS tag NC_002655.2 4527895 4528458 D constitutive, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine; 3-methyladenine DNA glycosylase 4527895..4528458 Escherichia coli O157:H7 str. EDL933 961064 NP_290135.1 CDS yiaC NC_002655.2 4528455 4528895 D hypothetical protein 4528455..4528895 Escherichia coli O157:H7 str. EDL933 961063 NP_290136.1 CDS bisC NC_002655.2 4528864 4531083 R biotin sulfoxide reductase complement(4528864..4531083) Escherichia coli O157:H7 str. EDL933 961062 NP_290137.1 CDS yiaD NC_002655.2 4531350 4532009 D outer membrane lipoprotein 4531350..4532009 Escherichia coli O157:H7 str. EDL933 961061 NP_290138.2 CDS yiaE NC_002655.2 4532113 4533087 D Involved in the metabolism of aromatic amino acids; 2-hydroxyacid dehydrogenase 4532113..4533087 Escherichia coli O157:H7 str. EDL933 961060 NP_290139.1 CDS yiaF NC_002655.2 4533137 4533967 R hypothetical protein complement(4533137..4533967) Escherichia coli O157:H7 str. EDL933 961058 NP_290140.1 CDS yiaG NC_002655.2 4534281 4534571 D transcriptional regulator 4534281..4534571 Escherichia coli O157:H7 str. EDL933 961057 NP_290141.1 CDS cspA NC_002655.2 4534852 4535064 D cold-shock protein 4534852..4535064 Escherichia coli O157:H7 str. EDL933 961056 NP_290142.1 CDS Z4982 NC_002655.2 4535252 4535464 R small toxic polypeptide complement(4535252..4535464) Escherichia coli O157:H7 str. EDL933 961054 NP_290143.1 CDS glyS NC_002655.2 4535727 4537796 R glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit beta complement(4535727..4537796) Escherichia coli O157:H7 str. EDL933 961053 NP_290144.1 CDS glyQ NC_002655.2 4537806 4538717 R glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha complement(4537806..4538717) Escherichia coli O157:H7 str. EDL933 961052 NP_290145.1 CDS Z4985 NC_002655.2 4538812 4539111 R No significant matches; hypothetical protein complement(4538812..4539111) Escherichia coli O157:H7 str. EDL933 961051 NP_290146.1 CDS yiaH NC_002655.2 4539286 4540281 D hypothetical protein 4539286..4540281 Escherichia coli O157:H7 str. EDL933 961049 NP_290147.1 CDS yiaA NC_002655.2 4540323 4540763 R hypothetical protein complement(4540323..4540763) Escherichia coli O157:H7 str. EDL933 961048 NP_290148.1 CDS yiaB NC_002655.2 4540806 4541159 R hypothetical protein complement(4540806..4541159) Escherichia coli O157:H7 str. EDL933 961046 NP_290149.1 CDS xylB NC_002655.2 4541316 4542770 R xylulokinase complement(4541316..4542770) Escherichia coli O157:H7 str. EDL933 961045 NP_290150.1 CDS xylA NC_002655.2 4542842 4544164 R catalyzes the interconversion of D-xylose to D-xylulose; xylose isomerase complement(4542842..4544164) Escherichia coli O157:H7 str. EDL933 961044 NP_290151.1 CDS xylF NC_002655.2 4544530 4545522 D periplasmic substrate-binding component of the ATP-dependent xylose transport system; high affinity; D-xylose transporter subunit XylF 4544530..4545522 Escherichia coli O157:H7 str. EDL933 961043 NP_290152.1 CDS xylG NC_002655.2 4545600 4547141 D with XylFH is part of the high affinity xylose ABC transporter; xylose transporter ATP-binding subunit 4545600..4547141 Escherichia coli O157:H7 str. EDL933 961042 NP_290153.1 CDS xylH NC_002655.2 4547119 4548300 D xylose transport, membrane component 4547119..4548300 Escherichia coli O157:H7 str. EDL933 961041 NP_290154.1 CDS xylR NC_002655.2 4548378 4549556 D regulator of xyl operon 4548378..4549556 Escherichia coli O157:H7 str. EDL933 961040 NP_290155.1 CDS bax NC_002655.2 4549664 4550488 R hypothetical protein complement(4549664..4550488) Escherichia coli O157:H7 str. EDL933 961039 NP_290156.1 CDS malS NC_002655.2 4550808 4552838 D periplasmic enzyme that degrades maltodextrins that enter via the outer membrane porin LamB; hydrolyzes alpha-(1,4) glycosidic linkages; contains internal disulfide bonds; periplasmic alpha-amylase 4550808..4552838 Escherichia coli O157:H7 str. EDL933 961038 NP_290157.1 CDS avtA NC_002655.2 4553016 4554269 D transaminase C; catalyzes transamination of alanine, valine, and 2-aminobutyrate with their respective 2-keto acids; also catalyzes terminal step in valine biosynthesis; valine--pyruvate transaminase 4553016..4554269 Escherichia coli O157:H7 str. EDL933 961032 NP_290158.1 CDS yiaI NC_002655.2 4554421 4554894 R hypothetical protein complement(4554421..4554894) Escherichia coli O157:H7 str. EDL933 961031 NP_290159.1 CDS Z4999 NC_002655.2 4554445 4554789 D No significant matches; hypothetical protein 4554445..4554789 Escherichia coli O157:H7 str. EDL933 961029 NP_290160.1 CDS Z5000 NC_002655.2 4555138 4555953 R regulatory protein complement(4555138..4555953) Escherichia coli O157:H7 str. EDL933 961028 NP_290161.1 CDS Z5001 NC_002655.2 4556179 4557579 D permease 4556179..4557579 Escherichia coli O157:H7 str. EDL933 960978 NP_290162.1 CDS Z5002 NC_002655.2 4557590 4559560 D hypothetical protein 4557590..4559560 Escherichia coli O157:H7 str. EDL933 960975 NP_290163.1 CDS yiaT NC_002655.2 4559690 4560430 R hypothetical protein complement(4559690..4560430) Escherichia coli O157:H7 str. EDL933 960972 NP_290164.1 CDS yiaU NC_002655.2 4560554 4561528 D LysR family transcriptional regulator 4560554..4561528 Escherichia coli O157:H7 str. EDL933 960970 NP_290165.1 CDS yiaV NC_002655.2 4561525 4562661 R hypothetical protein complement(4561525..4562661) Escherichia coli O157:H7 str. EDL933 960968 NP_290166.1 CDS yiaW NC_002655.2 4562667 4562990 R hypothetical protein complement(4562667..4562990) Escherichia coli O157:H7 str. EDL933 960967 NP_290167.1 CDS aldB NC_002655.2 4563535 4565163 R lactaldehyde dehydrogenase complement(4563535..4565163) Escherichia coli O157:H7 str. EDL933 960966 NP_290168.1 CDS Z5009 NC_002655.2 4565181 4566476 R hypothetical protein complement(4565181..4566476) Escherichia coli O157:H7 str. EDL933 960965 NP_290169.1 CDS yiaY NC_002655.2 4566606 4567757 R alcohol dehydrogenase complement(4566606..4567757) Escherichia coli O157:H7 str. EDL933 960964 NP_290170.1 CDS selB NC_002655.2 4567946 4569790 R selenocysteinyl-tRNA-specific translation factor complement(4567946..4569790) Escherichia coli O157:H7 str. EDL933 960963 NP_290171.1 CDS selA NC_002655.2 4569787 4571178 R catalyzes the formation of selenocysteinyl-tRNA(Sec) from seryl-tRNA(Sec) and L-selenophosphate in selenoprotein biosynthesis; selenocysteine synthase complement(4569787..4571178) Escherichia coli O157:H7 str. EDL933 960961 NP_290172.1 CDS yibF NC_002655.2 4571276 4571884 R glutathione S-transferase complement(4571276..4571884) Escherichia coli O157:H7 str. EDL933 960960 NP_290173.1 CDS rhsA NC_002655.2 4572113 4576246 D rhsA protein in rhs element 4572113..4576246 Escherichia coli O157:H7 str. EDL933 960959 NP_290174.1 CDS yibA NC_002655.2 4576267 4577109 D hypothetical protein 4576267..4577109 Escherichia coli O157:H7 str. EDL933 960958 NP_290175.1 CDS yibJ NC_002655.2 4577157 4578095 D hypothetical protein 4577157..4578095 Escherichia coli O157:H7 str. EDL933 960957 NP_290176.1 CDS yibG NC_002655.2 4578107 4578568 D hypothetical protein 4578107..4578568 Escherichia coli O157:H7 str. EDL933 960956 NP_290177.1 CDS yibH NC_002655.2 4580172 4581308 R hypothetical protein complement(4580172..4581308) Escherichia coli O157:H7 str. EDL933 960955 NP_290178.1 CDS yibI NC_002655.2 4581311 4581673 R hypothetical protein complement(4581311..4581673) Escherichia coli O157:H7 str. EDL933 960954 NP_290179.1 CDS mtlA NC_002655.2 4582210 4584123 D PTS system mannitol-specific transporter subunit IIABC 4582210..4584123 Escherichia coli O157:H7 str. EDL933 960953 NP_290180.1 CDS mtlD NC_002655.2 4584218 4585366 D mannitol-1-phosphate 5-dehydrogenase 4584218..4585366 Escherichia coli O157:H7 str. EDL933 960952 NP_290181.1 CDS mtlR NC_002655.2 4585366 4585953 D Acts as a repressor of the mtlAD operon; mannitol repressor protein 4585366..4585953 Escherichia coli O157:H7 str. EDL933 960951 NP_290182.1 CDS yibL NC_002655.2 4586459 4586821 D hypothetical protein 4586459..4586821 Escherichia coli O157:H7 str. EDL933 960950 NP_290183.1 CDS Z5027 NC_002655.2 4587135 4587293 R No significant matches; hypothetical protein complement(4587135..4587293) Escherichia coli O157:H7 str. EDL933 960949 NP_290184.1 CDS Z5028 NC_002655.2 4587466 4588047 D No significant matches; hypothetical protein 4587466..4588047 Escherichia coli O157:H7 str. EDL933 960948 NP_290185.1 CDS Z5029 NC_002655.2 4588091 4592857 D adhesin 4588091..4592857 Escherichia coli O157:H7 str. EDL933 960947 NP_290186.1 CDS lldP NC_002655.2 4593225 4594880 D L-lactate permease 4593225..4594880 Escherichia coli O157:H7 str. EDL933 960946 NP_290187.1 CDS lldR NC_002655.2 4594880 4595656 D represses the lctPRD operon; DNA-binding transcriptional repressor LldR 4594880..4595656 Escherichia coli O157:H7 str. EDL933 960945 NP_290188.1 CDS lldD NC_002655.2 4595653 4596843 D flavin mononucleotide-dependent dehydrogenase; functions in aerobic respiration and also has a role in anaerobic nitrate respiration; L-lactate dehydrogenase 4595653..4596843 Escherichia coli O157:H7 str. EDL933 960943 NP_290189.1 CDS yibK NC_002655.2 4597029 4597502 D member of the SPOUT superfamily of RNA methyltransferases; no methyltransferase activity observed with certain tRNA substrates; tRNA/rRNA methyltransferase YibK 4597029..4597502 Escherichia coli O157:H7 str. EDL933 960941 NP_290190.1 CDS cysE NC_002655.2 4597555 4598376 R catalyzes the O-acetylation of serine; serine acetyltransferase complement(4597555..4598376) Escherichia coli O157:H7 str. EDL933 960940 NP_290191.1 CDS gpsA NC_002655.2 4598456 4599475 R catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase complement(4598456..4599475) Escherichia coli O157:H7 str. EDL933 960939 NP_290192.1 CDS secB NC_002655.2 4599475 4599942 R molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA; preprotein translocase subunit SecB complement(4599475..4599942) Escherichia coli O157:H7 str. EDL933 960938 NP_290193.1 CDS grxC NC_002655.2 4600005 4600256 R glutaredoxin 3 complement(4600005..4600256) Escherichia coli O157:H7 str. EDL933 960937 NP_290194.1 CDS yibN NC_002655.2 4600398 4600829 R hypothetical protein complement(4600398..4600829) Escherichia coli O157:H7 str. EDL933 960936 NP_290195.1 CDS yibO NC_002655.2 4601074 4602618 D catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate; phosphoglyceromutase 4601074..4602618 Escherichia coli O157:H7 str. EDL933 960935 NP_290196.1 CDS yibP NC_002655.2 4602628 4603911 D hypothetical protein 4602628..4603911 Escherichia coli O157:H7 str. EDL933 960933 NP_290197.1 CDS yibQ NC_002655.2 4604041 4604874 D hypothetical protein 4604041..4604874 Escherichia coli O157:H7 str. EDL933 960932 NP_290198.1 CDS yibD NC_002655.2 4604880 4605896 R glycosyl transferase complement(4604880..4605896) Escherichia coli O157:H7 str. EDL933 960931 NP_290199.1 CDS tdh NC_002655.2 4606135 4607160 R converts threonine and NAD to 1,2-amino-3-oxobutanoate and NADH; functions in threonine catabolism; L-threonine 3-dehydrogenase complement(4606135..4607160) Escherichia coli O157:H7 str. EDL933 960930 NP_290200.1 CDS kbl NC_002655.2 4607170 4608366 R catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine; 2-amino-3-ketobutyrate CoA ligase complement(4607170..4608366) Escherichia coli O157:H7 str. EDL933 960928 NP_290201.1 CDS htrL NC_002655.2 4608641 4609513 R hypothetical protein complement(4608641..4609513) Escherichia coli O157:H7 str. EDL933 960927 NP_290202.1 CDS rfaD NC_002655.2 4609803 4610735 D catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose; ADP-L-glycero-D-manno-heptose-6-epimerase 4609803..4610735 Escherichia coli O157:H7 str. EDL933 960926 NP_290203.1 CDS rfaF NC_002655.2 4610745 4611791 D catalyzes the transfer of the second heptose to the heptosyl-KDO2 moiety of the lipopolysaccharide inner core; ADP-heptose--LPS heptosyltransferase 4610745..4611791 Escherichia coli O157:H7 str. EDL933 960925 NP_290204.1 CDS rfaC NC_002655.2 4611795 4612787 D ADP-heptose--LPS heptosyltransferase 4611795..4612787 Escherichia coli O157:H7 str. EDL933 960924 NP_290205.1 CDS waaL NC_002655.2 4612784 4613992 D LPS biosynthesis rpteon 4612784..4613992 Escherichia coli O157:H7 str. EDL933 960923 NP_290206.1 CDS waaD NC_002655.2 4614028 4615170 R LPS biosynthesis rpteon complement(4614028..4615170) Escherichia coli O157:H7 str. EDL933 960920 NP_290207.1 CDS waaJ NC_002655.2 4615179 4616192 R LPS biosynthesis rpteon complement(4615179..4616192) Escherichia coli O157:H7 str. EDL933 960919 NP_290208.1 CDS waaY NC_002655.2 4616217 4616924 R lipopolysaccharide core biosynthesis protein complement(4616217..4616924) Escherichia coli O157:H7 str. EDL933 960918 NP_290209.1 CDS waaI NC_002655.2 4616950 4617957 R LPS biosynthesis rpteon complement(4616950..4617957) Escherichia coli O157:H7 str. EDL933 960917 NP_290210.1 CDS waaP NC_002655.2 4618000 4618806 R LPS biosynthesis rpteon complement(4618000..4618806) Escherichia coli O157:H7 str. EDL933 960916 NP_290211.1 CDS rfaG NC_002655.2 4618790 4619914 R glucosyltransferase I; lipopolysaccharide core biosynthesis complement(4618790..4619914) Escherichia coli O157:H7 str. EDL933 960915 NP_290212.1 CDS waaQ NC_002655.2 4619911 4620969 R lipopolysaccharide core biosynthesis protein complement(4619911..4620969) Escherichia coli O157:H7 str. EDL933 960914 NP_290213.1 CDS kdtA NC_002655.2 4621382 4622659 D catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A; 3-deoxy-D-manno-octulosonic-acid transferase 4621382..4622659 Escherichia coli O157:H7 str. EDL933 960913 NP_290214.1 CDS coaD NC_002655.2 4622667 4623146 D Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase 4622667..4623146 Escherichia coli O157:H7 str. EDL933 960912 NP_290215.1 CDS mutM NC_002655.2 4623185 4623994 R Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase complement(4623185..4623994) Escherichia coli O157:H7 str. EDL933 960911 NP_290216.1 CDS rpmG NC_002655.2 4624092 4624259 R in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 complement(4624092..4624259) Escherichia coli O157:H7 str. EDL933 960910 NP_290217.1 CDS rpmB NC_002655.2 4624280 4624516 R required for 70S ribosome assembly; 50S ribosomal protein L28 complement(4624280..4624516) Escherichia coli O157:H7 str. EDL933 960909 NP_290218.1 CDS radC NC_002655.2 4624733 4625407 R Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase; DNA repair protein RadC complement(4624733..4625407) Escherichia coli O157:H7 str. EDL933 960908 NP_290219.2 CDS dfp NC_002655.2 4625573 4626793 D catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine; bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase 4625573..4626793 Escherichia coli O157:H7 str. EDL933 960907 NP_290220.1 CDS dut NC_002655.2 4626774 4627229 D catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 4626774..4627229 Escherichia coli O157:H7 str. EDL933 960906 NP_290221.2 CDS slmA NC_002655.2 4627336 4627932 D FtsZ binding protein; synthetically lethal with a defect in the Min system; this protein is the first identified nucleoid occlusion factor which works along with the Min system to properly position the FtsZ ring assembly; nucleoid occlusion protein 4627336..4627932 Escherichia coli O157:H7 str. EDL933 960905 NP_290222.1 CDS pyrE NC_002655.2 4627969 4628610 R involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase complement(4627969..4628610) Escherichia coli O157:H7 str. EDL933 960904 NP_290223.1 CDS rph NC_002655.2 4628676 4629392 R RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs; ribonuclease PH complement(4628676..4629392) Escherichia coli O157:H7 str. EDL933 960903 NP_290224.1 CDS yicC NC_002655.2 4629519 4630382 D hypothetical protein 4629519..4630382 Escherichia coli O157:H7 str. EDL933 960902 NP_290225.2 CDS dinD NC_002655.2 4630603 4631427 D DNA-damage-inducible protein D 4630603..4631427 Escherichia coli O157:H7 str. EDL933 960901 NP_290226.1 CDS yicG NC_002655.2 4631665 4632336 D hypothetical protein 4631665..4632336 Escherichia coli O157:H7 str. EDL933 960900 NP_290227.2 CDS ligB NC_002655.2 4632333 4634015 R this ligase is similar to LigA but it lacks the C-terminal BRCT domain; catalyzes strand joining of nicked DNA in the presence of a divalent cation and NAD+; NAD-dependent DNA ligase LigB complement(4632333..4634015) Escherichia coli O157:H7 str. EDL933 960898 NP_290228.1 CDS gmk NC_002655.2 4634273 4634896 D Essential for recycling GMP and indirectly, cGMP; guanylate kinase 4634273..4634896 Escherichia coli O157:H7 str. EDL933 960897 NP_290229.1 CDS rpoZ NC_002655.2 4634951 4635226 D promotes RNA polymerase assembly or stability; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega 4634951..4635226 Escherichia coli O157:H7 str. EDL933 960896 NP_290230.1 CDS spoT NC_002655.2 4635245 4637353 D bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase 4635245..4637353 Escherichia coli O157:H7 str. EDL933 960895 NP_290231.1 CDS spoU NC_002655.2 4637360 4638049 D specifically modifies tRNA at position G18; tRNA guanosine-2'-O-methyltransferase 4637360..4638049 Escherichia coli O157:H7 str. EDL933 960894 NP_290232.2 CDS recG NC_002655.2 4638055 4640136 D catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG 4638055..4640136 Escherichia coli O157:H7 str. EDL933 960893 NP_290233.1 CDS Z5079 NC_002655.2 4640121 4640987 R No significant matches; hypothetical protein complement(4640121..4640987) Escherichia coli O157:H7 str. EDL933 960892 NP_290234.1 CDS gltS NC_002655.2 4640990 4642195 R glutamate transport complement(4640990..4642195) Escherichia coli O157:H7 str. EDL933 960891 NP_290235.1 CDS yicE NC_002655.2 4642475 4643866 D transporter 4642475..4643866 Escherichia coli O157:H7 str. EDL933 960890 NP_290236.1 CDS yicH NC_002655.2 4643987 4645696 D hypothetical protein 4643987..4645696 Escherichia coli O157:H7 str. EDL933 960889 NP_290237.1 CDS yicI NC_002655.2 4645749 4648067 R catalyzes the transfer of alpha-xylosyl residue from alpha-xyloside to xylose, glucose, mannose, fructose, maltose, isomaltose, nigerose, kojibiose, sucrose, and trehalose; shows higher activity against alpha-xylosyl fluoride, isoprimeverose (6-O-alpha-xylopyranosyl-glucopyranose), and alpha-xyloside in xyloglucan oligosaccharides; alpha-xylosidase complement(4645749..4648067) Escherichia coli O157:H7 str. EDL933 960888 NP_290238.2 CDS yicJ NC_002655.2 4648077 4649459 R may be involved in the transport of galactosides-pentoses-hexuronides; transporter complement(4648077..4649459) Escherichia coli O157:H7 str. EDL933 960887 NP_290239.1 CDS intL NC_002655.2 4650042 4651223 D integrase for prophage 933L and the LEE pathogenicity island 4650042..4651223 Escherichia coli O157:H7 str. EDL933 960885 NP_290240.1 CDS Z5088 NC_002655.2 4651322 4651672 D hypothetical protein 4651322..4651672 Escherichia coli O157:H7 str. EDL933 960883 NP_290241.1 CDS Z5089 NC_002655.2 4651861 4652538 D transposase 4651861..4652538 Escherichia coli O157:H7 str. EDL933 960882 NP_290242.1 CDS Z5091 NC_002655.2 4652789 4653163 D hypothetical protein 4652789..4653163 Escherichia coli O157:H7 str. EDL933 960881 NP_290243.1 CDS Z5092 NC_002655.2 4653160 4653651 D hypothetical protein 4653160..4653651 Escherichia coli O157:H7 str. EDL933 960880 NP_290244.1 CDS Z5093 NC_002655.2 4653663 4653860 D hypothetical protein 4653663..4653860 Escherichia coli O157:H7 str. EDL933 960879 NP_290245.1 CDS Z5094 NC_002655.2 4653945 4654286 D hypothetical protein 4653945..4654286 Escherichia coli O157:H7 str. EDL933 960878 NP_290246.1 CDS Z5095 NC_002655.2 4654526 4654672 D hypothetical protein 4654526..4654672 Escherichia coli O157:H7 str. EDL933 960877 NP_290247.1 CDS Z5096 NC_002655.2 4655042 4655443 D prophage-associated protein 4655042..4655443 Escherichia coli O157:H7 str. EDL933 960876 NP_290248.1 CDS Z5097 NC_002655.2 4655440 4655787 D prophage-associated protein 4655440..4655787 Escherichia coli O157:H7 str. EDL933 960874 NP_290249.1 CDS Z5098 NC_002655.2 4655837 4657375 D prophage-associated protein 4655837..4657375 Escherichia coli O157:H7 str. EDL933 960873 NP_290250.1 CDS espF NC_002655.2 4658240 4658986 R hypothetical protein complement(4658240..4658986) Escherichia coli O157:H7 str. EDL933 960871 NP_290251.1 CDS Z5102 NC_002655.2 4659071 4659349 R hypothetical protein complement(4659071..4659349) Escherichia coli O157:H7 str. EDL933 960870 NP_290252.1 CDS escF NC_002655.2 4659355 4659576 R hypothetical protein complement(4659355..4659576) Escherichia coli O157:H7 str. EDL933 960869 NP_290253.1 CDS Z5104 NC_002655.2 4659612 4660019 R hypothetical protein complement(4659612..4660019) Escherichia coli O157:H7 str. EDL933 960868 NP_290254.1 CDS espB NC_002655.2 4660026 4660964 R hypothetical protein complement(4660026..4660964) Escherichia coli O157:H7 str. EDL933 960867 NP_290255.1 CDS espD NC_002655.2 4660985 4662109 R hypothetical protein complement(4660985..4662109) Escherichia coli O157:H7 str. EDL933 960866 NP_290256.1 CDS espA NC_002655.2 4662122 4662700 R hypothetical protein complement(4662122..4662700) Escherichia coli O157:H7 str. EDL933 960865 NP_290257.1 CDS sepL NC_002655.2 4662759 4663814 R hypothetical protein complement(4662759..4663814) Escherichia coli O157:H7 str. EDL933 960864 NP_290258.1 CDS escD NC_002655.2 4663957 4665177 D hypothetical protein 4663957..4665177 Escherichia coli O157:H7 str. EDL933 960863 NP_290259.1 CDS eae NC_002655.2 4665441 4668245 R intimin adherence protein complement(4665441..4668245) Escherichia coli O157:H7 str. EDL933 960862 NP_290260.1 CDS Z5111 NC_002655.2 4668305 4668775 R hypothetical protein complement(4668305..4668775) Escherichia coli O157:H7 str. EDL933 960861 NP_290261.1 CDS tir NC_002655.2 4668913 4670589 R translocated intimin receptor protein complement(4668913..4670589) Escherichia coli O157:H7 str. EDL933 960860 NP_290262.1 CDS Z5113 NC_002655.2 4671013 4671624 R hypothetical protein complement(4671013..4671624) Escherichia coli O157:H7 str. EDL933 960859 NP_290263.1 CDS Z5114 NC_002655.2 4671890 4672273 D hypothetical protein 4671890..4672273 Escherichia coli O157:H7 str. EDL933 960858 NP_290264.1 CDS Z5115 NC_002655.2 4672471 4672977 R hypothetical protein complement(4672471..4672977) Escherichia coli O157:H7 str. EDL933 960857 NP_290265.1 CDS sepQ NC_002655.2 4673008 4673925 R hypothetical protein complement(4673008..4673925) Escherichia coli O157:H7 str. EDL933 960856 NP_290266.1 CDS Z5117 NC_002655.2 4673888 4674163 R hypothetical protein complement(4673888..4674163) Escherichia coli O157:H7 str. EDL933 960855 NP_290267.1 CDS Z5118 NC_002655.2 4674297 4674674 R hypothetical protein complement(4674297..4674674) Escherichia coli O157:H7 str. EDL933 960854 NP_290268.1 CDS escN NC_002655.2 4674677 4676017 R hypothetical protein complement(4674677..4676017) Escherichia coli O157:H7 str. EDL933 960853 NP_290269.1 CDS escV NC_002655.2 4676001 4678028 R hypothetical protein complement(4676001..4678028) Escherichia coli O157:H7 str. EDL933 960852 NP_290270.1 CDS Z5121 NC_002655.2 4678025 4678378 R hypothetical protein complement(4678025..4678378) Escherichia coli O157:H7 str. EDL933 960851 NP_290271.1 CDS sepZ NC_002655.2 4678563 4678862 D hypothetical protein 4678563..4678862 Escherichia coli O157:H7 str. EDL933 960850 NP_290272.1 CDS Z5123 NC_002655.2 4678895 4679323 D hypothetical protein 4678895..4679323 Escherichia coli O157:H7 str. EDL933 960849 NP_290273.1 CDS escJ NC_002655.2 4679326 4679898 D hypothetical protein 4679326..4679898 Escherichia coli O157:H7 str. EDL933 960848 NP_290274.1 CDS Z5125 NC_002655.2 4679904 4680359 D hypothetical protein 4679904..4680359 Escherichia coli O157:H7 str. EDL933 960847 NP_290275.1 CDS escC NC_002655.2 4680359 4681897 D hypothetical protein 4680359..4681897 Escherichia coli O157:H7 str. EDL933 960846 NP_290276.1 CDS cesD NC_002655.2 4681911 4682366 D hypothetical protein 4681911..4682366 Escherichia coli O157:H7 str. EDL933 960845 NP_290277.1 CDS Z5128 NC_002655.2 4682750 4683163 R hypothetical protein complement(4682750..4683163) Escherichia coli O157:H7 str. EDL933 960843 NP_290278.1 CDS Z5129 NC_002655.2 4683218 4683589 R negative regulator GrlR complement(4683218..4683589) Escherichia coli O157:H7 str. EDL933 960842 NP_290279.1 CDS Z5131 NC_002655.2 4683785 4684243 D hypothetical protein 4683785..4684243 Escherichia coli O157:H7 str. EDL933 960841 NP_290280.1 CDS escU NC_002655.2 4684240 4685277 R member of a type III secretion system which is part of a pathogenicity island in Salmonella, Yersinia and pathogenic Escherichia coli; secretion system apparatus protein SsaU complement(4684240..4685277) Escherichia coli O157:H7 str. EDL933 960840 NP_290281.1 CDS escT NC_002655.2 4685270 4686046 R hypothetical protein complement(4685270..4686046) Escherichia coli O157:H7 str. EDL933 960839 NP_290282.1 CDS escS NC_002655.2 4686046 4686315 R hypothetical protein complement(4686046..4686315) Escherichia coli O157:H7 str. EDL933 960838 NP_290283.1 CDS escR NC_002655.2 4686315 4686968 R part of a set of proteins involved in the infection of eukaryotic cells; in plant pathogens involved in the hypersensitivity response; type III secretion system protein complement(4686315..4686968) Escherichia coli O157:H7 str. EDL933 960837 NP_290284.1 CDS Z5136 NC_002655.2 4686973 4687587 R hypothetical protein complement(4686973..4687587) Escherichia coli O157:H7 str. EDL933 960836 NP_290285.1 CDS Z5137 NC_002655.2 4687613 4688212 R hypothetical protein complement(4687613..4688212) Escherichia coli O157:H7 str. EDL933 960835 NP_290286.1 CDS Z5138 NC_002655.2 4688209 4688532 R hypothetical protein complement(4688209..4688532) Escherichia coli O157:H7 str. EDL933 960834 NP_290287.1 CDS Z5139 NC_002655.2 4688536 4688754 R hypothetical protein complement(4688536..4688754) Escherichia coli O157:H7 str. EDL933 960833 NP_290288.1 CDS Z5140 NC_002655.2 4688769 4689158 R hypothetical protein complement(4688769..4689158) Escherichia coli O157:H7 str. EDL933 960828 NP_290289.1 CDS Z5142 NC_002655.2 4690403 4691599 D hypothetical protein 4690403..4691599 Escherichia coli O157:H7 str. EDL933 960827 NP_290290.1 CDS Z5143 NC_002655.2 4691727 4692545 D hypothetical protein 4691727..4692545 Escherichia coli O157:H7 str. EDL933 960826 NP_290291.1 CDS yicL NC_002655.2 4693565 4694488 D permease transporter 4693565..4694488 Escherichia coli O157:H7 str. EDL933 960823 NP_290292.1 CDS nlpA NC_002655.2 4694492 4695310 R hypothetical protein complement(4694492..4695310) Escherichia coli O157:H7 str. EDL933 960822 NP_290293.1 CDS Z5148 NC_002655.2 4695463 4695825 D No significant matches; hypothetical protein 4695463..4695825 Escherichia coli O157:H7 str. EDL933 960821 NP_290294.2 CDS nepI NC_002655.2 4695866 4697056 R experimental results in Escherichia coli suggest that this gene encodes an inosine export protein; member of major facilitator superfamily; MFS; ribonucleoside transporter complement(4695866..4697056) Escherichia coli O157:H7 str. EDL933 960820 NP_290295.1 CDS Z5150 NC_002655.2 4697290 4697643 D hypothetical protein 4697290..4697643 Escherichia coli O157:H7 str. EDL933 960817 NP_290296.1 CDS Z5151 NC_002655.2 4697627 4697950 D hypothetical protein 4697627..4697950 Escherichia coli O157:H7 str. EDL933 960816 NP_290297.1 CDS yicN NC_002655.2 4698066 4698545 R hypothetical protein complement(4698066..4698545) Escherichia coli O157:H7 str. EDL933 960815 NP_290298.1 CDS Z5153 NC_002655.2 4698571 4698900 R hypothetical protein complement(4698571..4698900) Escherichia coli O157:H7 str. EDL933 960814 NP_290299.1 CDS Z5154 NC_002655.2 4698909 4699982 R hypothetical protein complement(4698909..4699982) Escherichia coli O157:H7 str. EDL933 960813 NP_290300.1 CDS yicP NC_002655.2 4700079 4701845 D catalyzes the formation of hypoxanthine from adenine; in E. coli this activity has been detected in mutant strains but not in wild type; cryptic adenine deaminase 4700079..4701845 Escherichia coli O157:H7 str. EDL933 960811 NP_290301.1 CDS uhpT NC_002655.2 4701891 4703282 R cytoplasmic membrane protein that functions as a monomer; catalyzes the active transport of sugar-phosphates such as glucose-6-phosphate with the obligatory exchange of inorganic phosphate or organophosphate; sugar phosphate antiporter complement(4701891..4703282) Escherichia coli O157:H7 str. EDL933 960810 NP_290302.1 CDS uhpC NC_002655.2 4703420 4704742 R membrane protein regulates uhpT expression; regulatory protein UhpC complement(4703420..4704742) Escherichia coli O157:H7 str. EDL933 960809 NP_290303.1 CDS uhpB NC_002655.2 4704749 4706254 R Member of the two-component regulatory system UhpB/UhpA involved in the regulation of the uptake of hexose ph; sensory histidine kinase UhpB complement(4704749..4706254) Escherichia coli O157:H7 str. EDL933 960807 NP_290304.1 CDS uhpA NC_002655.2 4706251 4706841 R response regulator in two-component regulatory system wtih UhpB; phosphorylated UhpA is a positive activator uhpT, a hexose phosphates transporter; DNA-binding transcriptional activator UhpA complement(4706251..4706841) Escherichia coli O157:H7 str. EDL933 960804 NP_290305.1 CDS Z5160 NC_002655.2 4707003 4708106 R No significant matches; hypothetical protein complement(4707003..4708106) Escherichia coli O157:H7 str. EDL933 960802 NP_290306.1 CDS Z5161 NC_002655.2 4708122 4708499 R No significant matches; hypothetical protein complement(4708122..4708499) Escherichia coli O157:H7 str. EDL933 960801 NP_290307.1 CDS Z5162 NC_002655.2 4708714 4709196 R No significant matches; hypothetical protein complement(4708714..4709196) Escherichia coli O157:H7 str. EDL933 960800 NP_290308.1 CDS Z5163 NC_002655.2 4709344 4710009 R No significant matches; hypothetical protein complement(4709344..4710009) Escherichia coli O157:H7 str. EDL933 960799 NP_290309.1 CDS ilvN NC_002655.2 4710260 4710550 R with IlvB catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase small subunit; acetolactate synthase 1 regulatory subunit complement(4710260..4710550) Escherichia coli O157:H7 str. EDL933 960798 NP_290310.1 CDS ilvB NC_002655.2 4710554 4712242 R catalyzes the formation of 2-acetolactate from pyruvate; acetolactate synthase catalytic subunit complement(4710554..4712242) Escherichia coli O157:H7 str. EDL933 960797 NP_290311.1 CDS ivbL NC_002655.2 4712348 4712446 R ilvB operon leader peptide complement(4712348..4712446) Escherichia coli O157:H7 str. EDL933 960796 NP_290312.1 CDS emrD NC_002655.2 4713374 4714564 D multidrug efflux protein involved in adaptation to low energy shock; multidrug resistance protein D 4713374..4714564 Escherichia coli O157:H7 str. EDL933 960794 NP_290313.1 CDS yidF NC_002655.2 4714572 4715069 R transcriptional regulator complement(4714572..4715069) Escherichia coli O157:H7 str. EDL933 960793 NP_290314.1 CDS yidG NC_002655.2 4715066 4715428 R hypothetical protein complement(4715066..4715428) Escherichia coli O157:H7 str. EDL933 960789 NP_290315.1 CDS yidH NC_002655.2 4715418 4715765 R hypothetical protein complement(4715418..4715765) Escherichia coli O157:H7 str. EDL933 960785 NP_290316.1 CDS yidI NC_002655.2 4715874 4716323 D hypothetical protein 4715874..4716323 Escherichia coli O157:H7 str. EDL933 960784 NP_290317.1 CDS yidJ NC_002655.2 4716370 4717863 R sulfatase complement(4716370..4717863) Escherichia coli O157:H7 str. EDL933 960781 NP_290318.1 CDS yidK NC_002655.2 4717860 4719575 R uncharacterized member of the SSS superfamily of sodium-dependent solute transporters; unknown function; symporter YidK complement(4717860..4719575) Escherichia coli O157:H7 str. EDL933 960779 NP_290319.1 CDS yidL NC_002655.2 4719712 4720635 D AraC family transcriptional regulator 4719712..4720635 Escherichia coli O157:H7 str. EDL933 960778 NP_290320.1 CDS Z5177 NC_002655.2 4720632 4721954 R 6-phospho-beta-glucosidase complement(4720632..4721954) Escherichia coli O157:H7 str. EDL933 960777 NP_290321.1 CDS Z5178 NC_002655.2 4721954 4723576 R PTS component complement(4721954..4723576) Escherichia coli O157:H7 str. EDL933 960773 NP_290322.1 CDS yidP NC_002655.2 4723866 4724582 D transcriptional regulator 4723866..4724582 Escherichia coli O157:H7 str. EDL933 960772 NP_290323.2 CDS yidE NC_002655.2 4724579 4726240 R hypothetical protein complement(4724579..4726240) Escherichia coli O157:H7 str. EDL933 960771 NP_290324.2 CDS ibpB NC_002655.2 4726436 4726864 R 16 kDa heat shock protein B; associates with aggregated proteins, together with ibpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; ATP-independent; heat shock chaperone IbpB complement(4726436..4726864) Escherichia coli O157:H7 str. EDL933 960767 NP_290325.1 CDS ibpA NC_002655.2 4726976 4727389 R with IbpB associates with aggregated proteins to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; heat shock protein IbpA complement(4726976..4727389) Escherichia coli O157:H7 str. EDL933 960764 NP_290326.2 CDS yidQ NC_002655.2 4727695 4728027 D hypothetical protein 4727695..4728027 Escherichia coli O157:H7 str. EDL933 960763 NP_290327.1 CDS yidR NC_002655.2 4728029 4729279 R hypothetical protein complement(4728029..4729279) Escherichia coli O157:H7 str. EDL933 960762 NP_290328.2 CDS yidS NC_002655.2 4729344 4730408 D FAD/NAD(P)-binding domain; oxidoreductase 4729344..4730408 Escherichia coli O157:H7 str. EDL933 960761 NP_290329.2 CDS Z5187 NC_002655.2 4730654 4731310 D hypothetical protein 4730654..4731310 Escherichia coli O157:H7 str. EDL933 960760 NP_290330.1 CDS yidA NC_002655.2 4731356 4732168 R YidA; catalyzes the dephosphorylation of erythrose 4-phosphate (preferred substrate), mannose 1-phosphate and p-nitrophenyl phosphate; hydrolyzes the alpha-D-glucose-1-phosphate but not the beta form; member of the haloacid dehalogenase-like hydrolases superfamily and Cof family of proteins; sugar phosphatase complement(4731356..4732168) Escherichia coli O157:H7 str. EDL933 960759 NP_290331.1 CDS yidB NC_002655.2 4732283 4732690 R hypothetical protein complement(4732283..4732690) Escherichia coli O157:H7 str. EDL933 960758 NP_290332.1 CDS gyrB NC_002655.2 4732921 4735335 R negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B complement(4732921..4735335) Escherichia coli O157:H7 str. EDL933 960757 NP_290333.1 CDS recF NC_002655.2 4735364 4736437 R Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F complement(4735364..4736437) Escherichia coli O157:H7 str. EDL933 960756 NP_290334.1 CDS dnaN NC_002655.2 4736437 4737537 R binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta complement(4736437..4737537) Escherichia coli O157:H7 str. EDL933 960755 NP_290335.1 CDS dnaA NC_002655.2 4737542 4738945 R binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosome replication initiator DnaA complement(4737542..4738945) Escherichia coli O157:H7 str. EDL933 960754 NP_290336.1 CDS rpmH NC_002655.2 4739552 4739692 D in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 4739552..4739692 Escherichia coli O157:H7 str. EDL933 960753 NP_290337.1 CDS rnpA NC_002655.2 4739709 4740068 D protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P 4739709..4740068 Escherichia coli O157:H7 str. EDL933 960752 NP_290338.1 CDS yidC NC_002655.2 4740292 4741938 D functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria; inner membrane protein translocase component YidC 4740292..4741938 Escherichia coli O157:H7 str. EDL933 960751 NP_290339.1 CDS trmE NC_002655.2 4742044 4743408 D in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE 4742044..4743408 Escherichia coli O157:H7 str. EDL933 960750 NP_290340.1 CDS Z5199 NC_002655.2 4743556 4743777 R No significant matches; hypothetical protein complement(4743556..4743777) Escherichia coli O157:H7 str. EDL933 960749 NP_290341.1 CDS Z5200 NC_002655.2 4743737 4745725 R hypothetical protein complement(4743737..4745725) Escherichia coli O157:H7 str. EDL933 960748 NP_290342.1 CDS Z5201 NC_002655.2 4745830 4745934 R No significant matches; hypothetical protein complement(4745830..4745934) Escherichia coli O157:H7 str. EDL933 960747 NP_290343.1 CDS tnaL NC_002655.2 4746125 4746199 D tryptophanase 4746125..4746199 Escherichia coli O157:H7 str. EDL933 960746 NP_290344.1 CDS tnaA NC_002655.2 4746405 4747835 D tryptophan indole-lyase; catalyzes the formation of indole and pyruvate from tryptophan; tryptophanase 4746405..4747835 Escherichia coli O157:H7 str. EDL933 960743 NP_290345.1 CDS tnaB NC_002655.2 4747926 4749173 D tryptophan transporter of low affinity; tryptophan permease 4747926..4749173 Escherichia coli O157:H7 str. EDL933 960741 NP_290346.1 CDS yidY NC_002655.2 4749305 4750480 D Confers resistance to chloramphenicol; multidrug efflux system protein MdtL 4749305..4750480 Escherichia coli O157:H7 str. EDL933 960740 NP_290347.1 CDS yidZ NC_002655.2 4750455 4751414 D Involved in anaerobic NO protection; DNA-binding transcriptional regulator YidZ 4750455..4751414 Escherichia coli O157:H7 str. EDL933 960738 NP_290348.1 CDS yieE NC_002655.2 4751559 4752320 D hypothetical protein 4751559..4752320 Escherichia coli O157:H7 str. EDL933 960737 NP_290349.1 CDS yieF NC_002655.2 4752342 4752908 D hypothetical protein 4752342..4752908 Escherichia coli O157:H7 str. EDL933 960732 NP_290350.1 CDS yieG NC_002655.2 4752962 4754299 R membrane / transport protein complement(4752962..4754299) Escherichia coli O157:H7 str. EDL933 960729 NP_290351.1 CDS yieH NC_002655.2 4754465 4755130 D YieH; catalyzes the dephosphorylation of phosphoenolpyruvate, AMP and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; member of the haloacid dehalogenase-like hydrolases superfamily; 6-phosphogluconate phosphatase 4754465..4755130 Escherichia coli O157:H7 str. EDL933 960728 NP_290352.1 CDS Z5211 NC_002655.2 4755267 4757675 R hypothetical protein complement(4755267..4757675) Escherichia coli O157:H7 str. EDL933 960727 NP_290353.1 CDS Z5212 NC_002655.2 4757976 4758647 D No significant matches; hypothetical protein 4757976..4758647 Escherichia coli O157:H7 str. EDL933 960725 NP_290354.1 CDS Z5213 NC_002655.2 4758738 4759163 D No significant matches; hypothetical protein 4758738..4759163 Escherichia coli O157:H7 str. EDL933 960723 NP_290355.1 CDS Z5214 NC_002655.2 4759632 4762016 R hypothetical protein complement(4759632..4762016) Escherichia coli O157:H7 str. EDL933 960719 NP_290356.1 CDS phoU NC_002655.2 4762542 4763267 R regulates several genes involved in high affinity phosphate uptake; under conditions of high phosphate concentrations downregulates the PHO regulon; transcriptional regulator PhoU complement(4762542..4763267) Escherichia coli O157:H7 str. EDL933 960717 NP_290357.1 CDS pstB NC_002655.2 4763282 4764055 R ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein complement(4763282..4764055) Escherichia coli O157:H7 str. EDL933 960716 NP_290358.1 CDS pstA NC_002655.2 4764238 4765128 R Part of the ABC transporter complex PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions; phosphate transporter permease subunit PtsA complement(4764238..4765128) Escherichia coli O157:H7 str. EDL933 960711 NP_290359.1 CDS pstC NC_002655.2 4765128 4766087 R part of the ATP-dependent phosphate uptake system PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions; phosphate transporter permease subunit PstC complement(4765128..4766087) Escherichia coli O157:H7 str. EDL933 960700 NP_290360.1 CDS pstS NC_002655.2 4766174 4767214 R phosphate ABC transporter substrate-binding protein complement(4766174..4767214) Escherichia coli O157:H7 str. EDL933 960698 NP_290361.1 CDS Z5220 NC_002655.2 4767426 4768508 R fimbrial protein complement(4767426..4768508) Escherichia coli O157:H7 str. EDL933 960697 NP_290362.1 CDS Z5221 NC_002655.2 4768536 4769606 R fimbrial protein complement(4768536..4769606) Escherichia coli O157:H7 str. EDL933 960696 NP_290363.1 CDS Z5222 NC_002655.2 4769618 4772152 R fimbrial usher complement(4769618..4772152) Escherichia coli O157:H7 str. EDL933 960695 NP_290364.1 CDS Z5223 NC_002655.2 4772174 4772335 R No significant matches; fimbrial chaperone complement(4772174..4772335) Escherichia coli O157:H7 str. EDL933 960693 NP_290365.1 CDS Z5224 NC_002655.2 4772476 4772859 R fimbrial chaperone complement(4772476..4772859) Escherichia coli O157:H7 str. EDL933 960691 NP_290366.1 CDS Z5225 NC_002655.2 4772963 4773565 R major fimbrial subunit complement(4772963..4773565) Escherichia coli O157:H7 str. EDL933 960681 NP_290368.1 CDS glmS NC_002655.2 4774265 4776094 R Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase complement(4774265..4776094) Escherichia coli O157:H7 str. EDL933 960579 NP_290369.1 CDS glmU NC_002655.2 4776256 4777626 R forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase complement(4776256..4777626) Escherichia coli O157:H7 str. EDL933 960502 NP_290370.1 CDS atpC NC_002655.2 4777978 4778397 R part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; ATP synthase F0F1 subunit epsilon complement(4777978..4778397) Escherichia coli O157:H7 str. EDL933 960452 NP_290371.1 CDS atpD NC_002655.2 4778418 4779800 R Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; ATP synthase F0F1 subunit beta complement(4778418..4779800) Escherichia coli O157:H7 str. EDL933 960448 NP_290372.1 CDS atpG NC_002655.2 4779827 4780690 R Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; ATP synthase F0F1 subunit gamma complement(4779827..4780690) Escherichia coli O157:H7 str. EDL933 960442 NP_290373.1 CDS atpA NC_002655.2 4780741 4782282 R produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; ATP synthase F0F1 subunit alpha complement(4780741..4782282) Escherichia coli O157:H7 str. EDL933 960441 NP_290374.1 CDS atpH NC_002655.2 4782295 4782828 R Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; ATP synthase F0F1 subunit delta complement(4782295..4782828) Escherichia coli O157:H7 str. EDL933 960439 NP_290375.1 CDS atpF NC_002655.2 4782843 4783313 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; ATP synthase F0F1 subunit B complement(4782843..4783313) Escherichia coli O157:H7 str. EDL933 960438 NP_290376.1 CDS atpE NC_002655.2 4783375 4783614 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0; ATP synthase F0F1 subunit C complement(4783375..4783614) Escherichia coli O157:H7 str. EDL933 960436 NP_290377.1 CDS atpB NC_002655.2 4783661 4784476 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; ATP synthase F0F1 subunit A complement(4783661..4784476) Escherichia coli O157:H7 str. EDL933 960435 NP_290378.2 CDS atpI NC_002655.2 4784485 4784865 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation; F0F1 ATP synthase subunit I complement(4784485..4784865) Escherichia coli O157:H7 str. EDL933 960433 NP_290379.1 CDS gidB NC_002655.2 4785482 4786105 R glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB complement(4785482..4786105) Escherichia coli O157:H7 str. EDL933 960431 NP_290380.1 CDS gidA NC_002655.2 4786169 4788058 R GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification protein GidA complement(4786169..4788058) Escherichia coli O157:H7 str. EDL933 960429 NP_290381.1 CDS mioC NC_002655.2 4788437 4788880 R An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin complement(4788437..4788880) Escherichia coli O157:H7 str. EDL933 960425 NP_290382.1 CDS asnC NC_002655.2 4788970 4789428 R transcriptional repressor of asnA which codes for aspartate-ammonia ligase; DNA-binding transcriptional regulator AsnC complement(4788970..4789428) Escherichia coli O157:H7 str. EDL933 960424 NP_290383.1 CDS asnA NC_002655.2 4789580 4790572 D catalyzes the formation of asparagine from aspartate and ammonia; asparagine synthetase AsnA 4789580..4790572 Escherichia coli O157:H7 str. EDL933 960423 NP_290384.2 CDS yieM NC_002655.2 4790577 4792028 R contains a von Willibrand factor type A domain; stimulates the ATPase activity of RavA; hypothetical protein complement(4790577..4792028) Escherichia coli O157:H7 str. EDL933 960421 NP_290385.2 CDS yieN NC_002655.2 4792022 4793518 R interacts with LdcI, lysine decarboxylase; may be active in late log/ early stationary phase; regulatory ATPase RavA complement(4792022..4793518) Escherichia coli O157:H7 str. EDL933 960420 NP_290386.1 CDS trkD NC_002655.2 4793741 4795609 D Responsible for the low-affinity transport of potassium into the cell; involved in potassium ion uptake under hyper-osmotic stress at a low pH; potassium transport protein Kup 4793741..4795609 Escherichia coli O157:H7 str. EDL933 960419 NP_290387.2 CDS rbsD NC_002655.2 4795776 4796195 D cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose; RbsD is required for efficient ribose utilization in E. coli; rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source; D-ribose pyranase 4795776..4796195 Escherichia coli O157:H7 str. EDL933 960418 NP_290388.1 CDS rbsA NC_002655.2 4796203 4797708 D with RbsBCD acts to import ribose into the cell; RbsA contains 2 ATP-binding domain; D-ribose transporter ATP-binding protein 4796203..4797708 Escherichia coli O157:H7 str. EDL933 960417 NP_290389.1 CDS rbsC NC_002655.2 4797713 4798678 D functions to transport ribose at high affinity; forms a complex with RbsA2C2B; ribose ABC transporter permease 4797713..4798678 Escherichia coli O157:H7 str. EDL933 960416 NP_290390.1 CDS rbsB NC_002655.2 4798703 4799593 D periplasmic substrate-binding component of the ATP-dependent ribose transport system; D-ribose transporter subunit RbsB 4798703..4799593 Escherichia coli O157:H7 str. EDL933 960415 NP_290391.1 CDS rbsK NC_002655.2 4799719 4800648 D catalyzes the formation of D-ribose 5-phosphate from ribose; ribokinase 4799719..4800648 Escherichia coli O157:H7 str. EDL933 960414 NP_290392.1 CDS rbsR NC_002655.2 4800652 4801644 D DNA-binding transcriptional repressor of ribose metabolism; transcriptional repressor RbsR 4800652..4801644 Escherichia coli O157:H7 str. EDL933 960413 NP_290393.1 CDS yieO NC_002655.2 4801610 4803037 R transporter complement(4801610..4803037) Escherichia coli O157:H7 str. EDL933 960412 NP_290394.1 CDS yieP NC_002655.2 4803060 4803752 R hypothetical protein complement(4803060..4803752) Escherichia coli O157:H7 str. EDL933 960411 NP_290395.1 CDS yifA NC_002655.2 4809553 4810392 R Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon; transcriptional regulator HdfR complement(4809553..4810392) Escherichia coli O157:H7 str. EDL933 959624 NP_290396.1 CDS yifE NC_002655.2 4810511 4810849 D hypothetical protein 4810511..4810849 Escherichia coli O157:H7 str. EDL933 960404 NP_290397.1 CDS yifB NC_002655.2 4810874 4812424 R among the AAA+ ATPases, the YifB protease belongs to the Helix 2 insert clade; unknown function; ATP-dependent protease complement(4810874..4812424) Escherichia coli O157:H7 str. EDL933 960403 NP_290398.1 CDS ilvL NC_002655.2 4812747 4812845 D ilvG operon leader peptide 4812747..4812845 Escherichia coli O157:H7 str. EDL933 960402 NP_290399.1 CDS ilvG NC_002655.2 4812985 4814631 D catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; acetolactate synthase 2 catalytic subunit 4812985..4814631 Escherichia coli O157:H7 str. EDL933 960401 NP_290400.1 CDS ilvM NC_002655.2 4814628 4814891 D acetolactate synthase 2 regulatory subunit 4814628..4814891 Escherichia coli O157:H7 str. EDL933 960400 NP_290401.1 CDS ilvE NC_002655.2 4814911 4815840 D catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase 4814911..4815840 Escherichia coli O157:H7 str. EDL933 960399 NP_290402.1 CDS ilvD NC_002655.2 4815906 4817756 D catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase 4815906..4817756 Escherichia coli O157:H7 str. EDL933 960398 NP_290403.1 CDS ilvA NC_002655.2 4817759 4819306 D threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway; threonine dehydratase 4817759..4819306 Escherichia coli O157:H7 str. EDL933 960397 NP_290404.1 CDS ilvY NC_002655.2 4819358 4820251 R participates in controlling several genes involved in isoleucine and valine biosynthesis; activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate; IlvY family transcriptional regulator complement(4819358..4820251) Escherichia coli O157:H7 str. EDL933 960396 NP_290405.1 CDS ilvC NC_002655.2 4820401 4821876 D catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase 4820401..4821876 Escherichia coli O157:H7 str. EDL933 960395 NP_290406.1 CDS ppiC NC_002655.2 4821922 4822203 R peptidyl-prolyl cis-trans isomerase C complement(4821922..4822203) Escherichia coli O157:H7 str. EDL933 960394 NP_290407.1 CDS Z5287 NC_002655.2 4822402 4822893 R hypothetical protein complement(4822402..4822893) Escherichia coli O157:H7 str. EDL933 960393 NP_290408.1 CDS rep NC_002655.2 4823068 4825089 D single-stranded DNA-dependent ATPase; initiates unwinding at a nick in the DNA; involved in DNA replication; ATP-dependent DNA helicase Rep 4823068..4825089 Escherichia coli O157:H7 str. EDL933 960392 NP_290409.1 CDS gppA NC_002655.2 4825136 4826620 R catalyzes the conversion of guanosine 5'-triphosphate,3'-diphosphate (pppGpp) to guanosine 5'-diphosphate,3'-diphosphate (ppGpp); pppGpp and ppGpp control the stringent response during amino acid starvation; guanosine pentaphosphate phosphohydrolase complement(4825136..4826620) Escherichia coli O157:H7 str. EDL933 960391 NP_290410.1 CDS rhlB NC_002655.2 4826756 4828021 R enables ATP-dependent unwinding of double stranded RNA as a component of the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation; ATP-dependent RNA helicase RhlB complement(4826756..4828021) Escherichia coli O157:H7 str. EDL933 960390 NP_290411.1 CDS trxA NC_002655.2 4828098 4828481 D thioredoxin 4828098..4828481 Escherichia coli O157:H7 str. EDL933 960389 NP_290412.1 CDS rhoL NC_002655.2 4828622 4828723 D rho operon leader peptide 4828622..4828723 Escherichia coli O157:H7 str. EDL933 960388 NP_290413.1 CDS rho NC_002655.2 4828808 4830067 D An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho 4828808..4830067 Escherichia coli O157:H7 str. EDL933 960387 NP_290414.1 CDS Z5294 NC_002655.2 4830077 4830295 D No significant matches; hypothetical protein 4830077..4830295 Escherichia coli O157:H7 str. EDL933 960386 NP_290415.1 CDS rfe NC_002655.2 4830307 4831410 D UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase 4830307..4831410 Escherichia coli O157:H7 str. EDL933 960385 NP_290416.1 CDS wzzE NC_002655.2 4831419 4832468 D Enterobacterial Common Antigen (ECA) polysaccharide chain length modulation protein; lipopolysaccharide biosynthesis protein WzzE 4831419..4832468 Escherichia coli O157:H7 str. EDL933 960383 NP_290417.1 CDS wecB NC_002655.2 4832482 4833654 D UDP-N-acetylglucosamine 2-epimerase 4832482..4833654 Escherichia coli O157:H7 str. EDL933 960382 NP_290418.1 CDS wecC NC_002655.2 4833651 4834913 D catalyzes the oxidation of UDP-N-acetyl-D-mannosamine to UDP-N-acetylmannosaminuronic acid; UDP-N-acetyl-D-mannosamine dehydrogenase 4833651..4834913 Escherichia coli O157:H7 str. EDL933 960381 NP_290419.1 CDS rffG NC_002655.2 4834913 4835980 D dTDP-glucose 4,6-dehydratase 4834913..4835980 Escherichia coli O157:H7 str. EDL933 960380 NP_290420.1 CDS rffH NC_002655.2 4835999 4836880 D glucose-1-phosphate thymidylyltransferase 4835999..4836880 Escherichia coli O157:H7 str. EDL933 960377 NP_290421.1 CDS wecD NC_002655.2 4836987 4837532 D TDP-fucosamine acetyltransferase 4836987..4837532 Escherichia coli O157:H7 str. EDL933 960376 NP_290422.1 CDS wecE NC_002655.2 4837537 4838667 D catalyzes the formation of dTDP-D-fucosamine from dTDP-4-oxo-6-deoxy-D-glucose in enterobacterial common antigen biosynthesis; TDP-4-oxo-6-deoxy-D-glucose transaminase 4837537..4838667 Escherichia coli O157:H7 str. EDL933 960375 NP_290423.1 CDS wzxE NC_002655.2 4838669 4839919 D cytochrome 4838669..4839919 Escherichia coli O157:H7 str. EDL933 960374 NP_290424.1 CDS Z5304 NC_002655.2 4839916 4840995 D catalyzes the synthesis of a lipid-linked intermediate involved in ECA synthesis; 4-alpha-L-fucosyltransferase 4839916..4840995 Escherichia coli O157:H7 str. EDL933 960373 NP_290425.1 CDS wecF NC_002655.2 4840992 4842344 D enterobacterial common antigen polymerase; common antigen polymerase 4840992..4842344 Escherichia coli O157:H7 str. EDL933 960372 NP_290426.1 CDS wecG NC_002655.2 4842347 4843087 D UDP-N-acetyl-D-mannosaminuronic acid transferase 4842347..4843087 Escherichia coli O157:H7 str. EDL933 960371 NP_290427.1 CDS yifK NC_002655.2 4843278 4844663 D uncharacterized member of the amino acid-polyamine-organocation (APC) superfamily of amino acid transporters; unknown function; transporter 4843278..4844663 Escherichia coli O157:H7 str. EDL933 960370 NP_290428.1 CDS aslB NC_002655.2 4845349 4846584 D arylsulfatase 4845349..4846584 Escherichia coli O157:H7 str. EDL933 960364 NP_290429.1 CDS aslA NC_002655.2 4846753 4848408 R arylsulfatase complement(4846753..4848408) Escherichia coli O157:H7 str. EDL933 960363 NP_290430.1 CDS hemY NC_002655.2 4849088 4850284 R protoheme IX biogenesis protein complement(4849088..4850284) Escherichia coli O157:H7 str. EDL933 960362 NP_290431.1 CDS hemX NC_002655.2 4850287 4851486 R uroporphyrinogen III C-methyltransferase complement(4850287..4851486) Escherichia coli O157:H7 str. EDL933 960361 NP_290432.1 CDS hemD NC_002655.2 4851508 4852248 R catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; functions in tetrapyrrole and heme biosynthesis; uroporphyrinogen-III synthase complement(4851508..4852248) Escherichia coli O157:H7 str. EDL933 960360 NP_290433.1 CDS hemC NC_002655.2 4852245 4853207 R transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis; porphobilinogen deaminase complement(4852245..4853207) Escherichia coli O157:H7 str. EDL933 960359 NP_290434.1 CDS cyaA NC_002655.2 4853574 4856120 D catalyzes transfer of adenylyl group of ATP from pyrophosphate to the 3'-hydroxyl group to form cyclic AMP; adenylate cyclase 4853574..4856120 Escherichia coli O157:H7 str. EDL933 960357 NP_290435.1 CDS cyaY NC_002655.2 4856160 4856480 R defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly; frataxin-like protein complement(4856160..4856480) Escherichia coli O157:H7 str. EDL933 960356 NP_290436.1 CDS Z5324 NC_002655.2 4856271 4856756 D hypothetical protein 4856271..4856756 Escherichia coli O157:H7 str. EDL933 960355 NP_290437.1 CDS Z5325 NC_002655.2 4856943 4857146 D No significant matches; hypothetical protein 4856943..4857146 Escherichia coli O157:H7 str. EDL933 960354 NP_290438.2 CDS dapF NC_002655.2 4857183 4858007 D involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate; diaminopimelate epimerase 4857183..4858007 Escherichia coli O157:H7 str. EDL933 960353 NP_290439.1 CDS yigA NC_002655.2 4858004 4858711 D hypothetical protein 4858004..4858711 Escherichia coli O157:H7 str. EDL933 960352 NP_290440.1 CDS xerC NC_002655.2 4858708 4859604 D site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerC 4858708..4859604 Escherichia coli O157:H7 str. EDL933 960351 NP_290441.1 CDS yigB NC_002655.2 4859604 4860320 D YigB; member of the haloacid dehalogenase (HAD)-like hydrolases superfamily of protein; unknown function; flavin mononucleotide phosphatase 4859604..4860320 Escherichia coli O157:H7 str. EDL933 960350 NP_290442.1 CDS uvrD NC_002655.2 4860404 4862566 D unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present; involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair.; DNA-dependent helicase II 4860404..4862566 Escherichia coli O157:H7 str. EDL933 960349 NP_290443.1 CDS Z5331 NC_002655.2 4862611 4863513 R hypothetical protein complement(4862611..4863513) Escherichia coli O157:H7 str. EDL933 960348 NP_290444.1 CDS Z5332 NC_002655.2 4863596 4864360 R hypothetical protein complement(4863596..4864360) Escherichia coli O157:H7 str. EDL933 960347 NP_290445.1 CDS corA NC_002655.2 4864730 4865680 D responsible for the influx of magnesium ions; magnesium/nickel/cobalt transporter CorA 4864730..4865680 Escherichia coli O157:H7 str. EDL933 960346 NP_290446.1 CDS Z5334 NC_002655.2 4865722 4866213 R No significant matches; hypothetical protein complement(4865722..4866213) Escherichia coli O157:H7 str. EDL933 960345 NP_290447.1 CDS Z5335 NC_002655.2 4866210 4867058 R No significant matches; hypothetical protein complement(4866210..4867058) Escherichia coli O157:H7 str. EDL933 960344 NP_290448.1 CDS Z5336 NC_002655.2 4867272 4867391 D magnesium/cobalt transporter CorA 4867272..4867391 Escherichia coli O157:H7 str. EDL933 960343 NP_290449.1 CDS Z5337 NC_002655.2 4867416 4867802 R No significant matches; hypothetical protein complement(4867416..4867802) Escherichia coli O157:H7 str. EDL933 960342 NP_290450.1 CDS Z5339 NC_002655.2 4868007 4868318 D No significant matches; hypothetical protein 4868007..4868318 Escherichia coli O157:H7 str. EDL933 960341 NP_290451.1 CDS rarD NC_002655.2 4868365 4869252 R hypothetical protein complement(4868365..4869252) Escherichia coli O157:H7 str. EDL933 960340 NP_290452.2 CDS yigI NC_002655.2 4869304 4869771 R hypothetical protein complement(4869304..4869771) Escherichia coli O157:H7 str. EDL933 960339 NP_290453.1 CDS pldA NC_002655.2 4869936 4870805 D catalyzes the hydrolysis of phosphatidylcholine; phospholipase A 4869936..4870805 Escherichia coli O157:H7 str. EDL933 960338 NP_290454.1 CDS recQ NC_002655.2 4870932 4872767 D functions in blocking illegitimate recombination, enhancing topoisomerase activity, initiating SOS signaling and clearing blocked replication forks; component of the RecF recombinational pathway; ATP-dependent DNA helicase RecQ 4870932..4872767 Escherichia coli O157:H7 str. EDL933 960337 NP_290455.1 CDS yigJ NC_002655.2 4873083 4873451 D hypothetical protein 4873083..4873451 Escherichia coli O157:H7 str. EDL933 960336 NP_290456.1 CDS yigK NC_002655.2 4873513 4873929 R hypothetical protein complement(4873513..4873929) Escherichia coli O157:H7 str. EDL933 960335 NP_290457.1 CDS pldB NC_002655.2 4874244 4875266 D lecithinase B; catalyzes the conversion of 1-lysophosphatidylcholine to glycerophosphocholine; can also hydrolyze 2-acyl glycerophosphoethanolamine and other substrates; lysophospholipase L2 4874244..4875266 Escherichia coli O157:H7 str. EDL933 960333 NP_290458.1 CDS Z5347 NC_002655.2 4875157 4876074 D purine and pyrimidine nucleotides are secondary substrates; yigL expression is regulated by heat shock, osmotic shock and starvation of glucose, phosphate or ammonium; sugar phosphatase 4875157..4876074 Escherichia coli O157:H7 str. EDL933 960332 NP_290459.1 CDS yigM NC_002655.2 4876150 4877049 D hypothetical protein 4876150..4877049 Escherichia coli O157:H7 str. EDL933 960331 NP_290460.1 CDS metR NC_002655.2 4876937 4877890 R regulator for metE and metH complement(4876937..4877890) Escherichia coli O157:H7 str. EDL933 960330 NP_290461.1 CDS metE NC_002655.2 4878126 4880387 D catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 4878126..4880387 Escherichia coli O157:H7 str. EDL933 960329 NP_290462.1 CDS Z5352 NC_002655.2 4880427 4881308 R hypothetical protein complement(4880427..4881308) Escherichia coli O157:H7 str. EDL933 960328 NP_290463.1 CDS udp NC_002655.2 4881504 4882265 D catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate; involved in the pyrimidine salvage pathway; uridine phosphorylase 4881504..4882265 Escherichia coli O157:H7 str. EDL933 960327 NP_290464.1 CDS yigN NC_002655.2 4882406 4883833 D YigN; nuclease that may cleave DNA structures arising during the recombination of short-inverted repeats and thereby prevents the inversion of the internal sequence; transcription is induced by DNA-damaging agents such as nalidixic acid or mitomycin C in a LexA-dependent manner; DNA recombination protein RmuC 4882406..4883833 Escherichia coli O157:H7 str. EDL933 960326 NP_290465.1 CDS ubiE NC_002655.2 4883928 4884683 D Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone; ubiquinone/menaquinone biosynthesis methyltransferase 4883928..4884683 Escherichia coli O157:H7 str. EDL933 960325 NP_290466.1 CDS yigP NC_002655.2 4884697 4885302 D hypothetical protein 4884697..4885302 Escherichia coli O157:H7 str. EDL933 960324 NP_290467.1 CDS ubiB NC_002655.2 4885299 4886939 D an Escherichia coli mutant results in accumulation of octaprenylphenol and no ubiquinone; functions in the formation of 2-octaprenyl-6-hydroxy-phenol from 2-octaprenylphenol in ubiquinone (coenzyme Q) biosynthesis; similar to eukaryotic proteins that exhibit kinase functions; ubiquinone biosynthesis protein UbiB 4885299..4886939 Escherichia coli O157:H7 str. EDL933 960323 NP_290468.1 CDS tatA NC_002655.2 4886976 4887287 D TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin-arginine translocation protein TatA 4886976..4887287 Escherichia coli O157:H7 str. EDL933 960322 NP_290469.2 CDS tatB NC_002655.2 4887291 4887806 D mediates the export of protein precursors bearing twin-arginine signal peptides; sec-independent translocase 4887291..4887806 Escherichia coli O157:H7 str. EDL933 960321 NP_290470.1 CDS tatC NC_002655.2 4887809 4888585 D with TatABE forms the twin-arginine translocation complex which is involved in the transport of proteins across the cytoplasmic membrane; twin-arginine protein translocation system subunit TatC 4887809..4888585 Escherichia coli O157:H7 str. EDL933 960320 NP_290471.1 CDS tatD NC_002655.2 4888615 4889409 D magnesium dependent; not involved in the Sec-independent protein export system; DNase TatD 4888615..4889409 Escherichia coli O157:H7 str. EDL933 960319 NP_290472.1 CDS rfaH NC_002655.2 4889406 4889894 R transcriptional activator RfaH complement(4889406..4889894) Escherichia coli O157:H7 str. EDL933 960318 NP_290473.1 CDS yigC NC_002655.2 4890061 4891554 D catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol; 3-octaprenyl-4-hydroxybenzoate carboxy-lyase 4890061..4891554 Escherichia coli O157:H7 str. EDL933 960317 NP_290474.1 CDS fre NC_002655.2 4891600 4892301 D NAD(P)H-flavin reductase; catalyzes the reversible oxidation/reduction of NAD(P) and flavine mononucleotide; in Salmonella and E. coli this protein also reduces aquacob(III)alamin to cob(II)alamin; FMN reductase 4891600..4892301 Escherichia coli O157:H7 str. EDL933 960316 NP_290475.1 CDS fadA NC_002655.2 4892493 4893656 R FadA; fatty acid oxidation complex component beta; functions in a heterotetramer with FadB; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids; 3-ketoacyl-CoA thiolase complement(4892493..4893656) Escherichia coli O157:H7 str. EDL933 960315 NP_290476.1 CDS fadB NC_002655.2 4893666 4895855 R includes enoyl-CoA hydratase, delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase, 3-hydroxyacyl-CoA dehydrogenase, and 3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities; forms a heterotetramer with FadA; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids; multifunctional fatty acid oxidation complex subunit alpha complement(4893666..4895855) Escherichia coli O157:H7 str. EDL933 960314 NP_290477.1 CDS pepQ NC_002655.2 4896045 4897376 D catalyzes the hydrolysis of dipeptides with a proline at the C-terminal; also catalyzes the low efficiency hydrolysis of organophosphate di- and tri-esters; proline dipeptidase 4896045..4897376 Escherichia coli O157:H7 str. EDL933 960313 NP_290478.1 CDS yigZ NC_002655.2 4897373 4897990 D hypothetical protein 4897373..4897990 Escherichia coli O157:H7 str. EDL933 960312 NP_290479.1 CDS trkH NC_002655.2 4898029 4899480 D potassium transporter 4898029..4899480 Escherichia coli O157:H7 str. EDL933 960311 NP_290480.1 CDS hemG NC_002655.2 4899492 4900037 D catalyzes the oxidation of protoporphyrinogen IX to form protoporphyrin IX; protoporphyrinogen oxidase 4899492..4900037 Escherichia coli O157:H7 str. EDL933 960310 NP_290481.1 CDS mobB NC_002655.2 4905622 4906134 R in Escherichia coli the MobB protein is not essential but has been found to interact with multiple proteins involved in the molybdopterin guanine dinucleotide cofactor biosynthesis pathway; molybdopterin-guanine dinucleotide biosynthesis protein B complement(4905622..4906134) Escherichia coli O157:H7 str. EDL933 960304 NP_290482.1 CDS mobA NC_002655.2 4906131 4906715 R in Escherichia coli MobA links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide during molybdenum cofactor biosynthesis; molybdopterin-guanine dinucleotide biosynthesis protein MobA complement(4906131..4906715) Escherichia coli O157:H7 str. EDL933 960303 NP_290483.1 CDS yihD NC_002655.2 4906785 4907054 D hypothetical protein 4906785..4907054 Escherichia coli O157:H7 str. EDL933 960302 NP_290484.1 CDS yihE NC_002655.2 4907131 4908117 D catalyzes the phosphorylation of protein substrates at serine and threonine residues in vitro; specific substrate in vivo has not been identified yet; plays a role in long-term cell survival and expression of surface appendages; serine/threonine protein kinase 4907131..4908117 Escherichia coli O157:H7 str. EDL933 960301 NP_290485.1 CDS dsbA NC_002655.2 4908134 4908760 D protein disulfide isomerase 4908134..4908760 Escherichia coli O157:H7 str. EDL933 960300 NP_290486.1 CDS yihF NC_002655.2 4908873 4910345 D hypothetical protein 4908873..4910345 Escherichia coli O157:H7 str. EDL933 960299 NP_290487.1 CDS yihG NC_002655.2 4910386 4911318 R acyltransferase complement(4910386..4911318) Escherichia coli O157:H7 str. EDL933 960298 NP_290488.1 CDS polA NC_002655.2 4911682 4914468 D has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I 4911682..4914468 Escherichia coli O157:H7 str. EDL933 960297 NP_290489.2 CDS engB NC_002655.2 4914850 4915482 R binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC complement(4914850..4915482) Escherichia coli O157:H7 str. EDL933 960295 NP_290491.1 CDS yihI NC_002655.2 4916064 4916570 D hypothetical protein 4916064..4916570 Escherichia coli O157:H7 str. EDL933 960293 NP_290492.2 CDS hemN NC_002655.2 4916759 4918132 D catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 4916759..4918132 Escherichia coli O157:H7 str. EDL933 960292 NP_290493.1 CDS glnG NC_002655.2 4918544 4919953 R response regulator of a two-component regulatory system involved in the activation of nitrogen assimilation genes; interacts with sigma-54; nitrogen regulation protein NR(I) complement(4918544..4919953) Escherichia coli O157:H7 str. EDL933 960291 NP_290494.1 CDS glnL NC_002655.2 4919965 4921014 R sensory histidine kinase in two-component regulatory system with GlnG; acts as a signal transducer which responds to the nitrogen level of cell and modulates the activity of ntrC by phosphorylation/dephosphorylation; nitrogen regulation protein NR(II) complement(4919965..4921014) Escherichia coli O157:H7 str. EDL933 960290 NP_290495.1 CDS glnA NC_002655.2 4921188 4922597 R forms a homododecamer; forms glutamine from ammonia and glutamate with the conversion of ATP to ADP and phosphate; also functions in the assimilation of ammonia; highly regulated protein controlled by the addition/removal of adenylyl groups by adenylyltransferase from specific tyrosine residues; addition of adenylyl groups results in inactivation of the enzyme; glutamine synthetase complement(4921188..4922597) Escherichia coli O157:H7 str. EDL933 960289 NP_290496.1 CDS yihK NC_002655.2 4922970 4924793 D GTP-binding protein 4922970..4924793 Escherichia coli O157:H7 str. EDL933 960288 NP_290497.1 CDS yihL NC_002655.2 4925010 4925720 D transcriptional regulator 4925010..4925720 Escherichia coli O157:H7 str. EDL933 960287 NP_290498.1 CDS yihM NC_002655.2 4925728 4926708 D hypothetical protein 4925728..4926708 Escherichia coli O157:H7 str. EDL933 960286 NP_290499.1 CDS yihN NC_002655.2 4926810 4928075 D resistance protein (transport) 4926810..4928075 Escherichia coli O157:H7 str. EDL933 960285 NP_290500.2 CDS ompL NC_002655.2 4928166 4928858 R porin involved in the transport of small molecular weight solutes (up to 600 Daltons) across the cell wall; specific substrate still unknown; porin complement(4928166..4928858) Escherichia coli O157:H7 str. EDL933 960284 NP_290501.1 CDS yihO NC_002655.2 4928925 4930334 R permease complement(4928925..4930334) Escherichia coli O157:H7 str. EDL933 960283 NP_290502.1 CDS yihP NC_002655.2 4930371 4931756 R permease complement(4930371..4931756) Escherichia coli O157:H7 str. EDL933 960282 NP_290503.1 CDS yihQ NC_002655.2 4931802 4933838 R alpha-glucosidase complement(4931802..4933838) Escherichia coli O157:H7 str. EDL933 960281 NP_290504.1 CDS Z5415 NC_002655.2 4933946 4934821 R hypothetical protein complement(4933946..4934821) Escherichia coli O157:H7 str. EDL933 960280 NP_290505.1 CDS yihR NC_002655.2 4934882 4935784 R aldose-1-epimerase complement(4934882..4935784) Escherichia coli O157:H7 str. EDL933 960279 NP_290506.1 CDS yihS NC_002655.2 4935851 4937092 R hypothetical protein complement(4935851..4937092) Escherichia coli O157:H7 str. EDL933 960276 NP_290507.1 CDS yihT NC_002655.2 4937108 4937986 R aldolase complement(4937108..4937986) Escherichia coli O157:H7 str. EDL933 960275 NP_290508.1 CDS yihU NC_002655.2 4938010 4938906 R dehydrogenase complement(4938010..4938906) Escherichia coli O157:H7 str. EDL933 960274 NP_290509.1 CDS yihV NC_002655.2 4939068 4939970 D kinase 4939068..4939970 Escherichia coli O157:H7 str. EDL933 960273 NP_290510.1 CDS yihW NC_002655.2 4939980 4940789 D DEOR-type transcriptional activator 4939980..4940789 Escherichia coli O157:H7 str. EDL933 960272 NP_290511.2 CDS yihX NC_002655.2 4940888 4941487 D phosphatase 4940888..4941487 Escherichia coli O157:H7 str. EDL933 960270 NP_290512.1 CDS rbn NC_002655.2 4941481 4942353 D RNase BN; required for 3' maturation of certain phage T4-encoded tRNAs; forms a dimer; specific for immature tRNA substrates containing incorrect residues within the universal CCA sequence; 3' to 5' exoribonuclease; ribonuclease BN 4941481..4942353 Escherichia coli O157:H7 str. EDL933 960269 NP_290513.1 CDS yihZ NC_002655.2 4942350 4942787 D hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase 4942350..4942787 Escherichia coli O157:H7 str. EDL933 960268 NP_290514.1 CDS yiiD NC_002655.2 4942784 4943773 D acetyltransferase 4942784..4943773 Escherichia coli O157:H7 str. EDL933 960267 NP_290515.1 CDS Z5428 NC_002655.2 4944085 4945077 D No significant matches; hypothetical protein 4944085..4945077 Escherichia coli O157:H7 str. EDL933 960266 NP_290516.1 CDS Z5429 NC_002655.2 4945084 4945998 D No significant matches; hypothetical protein 4945084..4945998 Escherichia coli O157:H7 str. EDL933 960265 NP_290517.1 CDS Z5430 NC_002655.2 4946391 4946507 R No significant matches; hypothetical protein complement(4946391..4946507) Escherichia coli O157:H7 str. EDL933 960264 NP_290518.1 CDS yiiE NC_002655.2 4946665 4946910 D hypothetical protein 4946665..4946910 Escherichia coli O157:H7 str. EDL933 960263 NP_290519.1 CDS yiiF NC_002655.2 4947127 4947369 D hypothetical protein 4947127..4947369 Escherichia coli O157:H7 str. EDL933 960262 NP_290520.1 CDS fdhE NC_002655.2 4947699 4948628 R required for the formation of active formate dehydrogenase; formate dehydrogenase accessory protein FdhE complement(4947699..4948628) Escherichia coli O157:H7 str. EDL933 960261 NP_290521.1 CDS fdoI NC_002655.2 4948625 4949260 R cytochrome b556(FDO) component; heme containing; formate dehydrogenase-O subunit gamma complement(4948625..4949260) Escherichia coli O157:H7 str. EDL933 960260 NP_290522.1 CDS fdoH NC_002655.2 4949257 4950159 R formate dehydrogenase-O, iron-sulfur subunit complement(4949257..4950159) Escherichia coli O157:H7 str. EDL933 960259 NP_290523.1 CDS fdoG NC_002655.2 4950172 4953222 R formate dehydrogenase-O, major subunit complement(4950172..4953222) Escherichia coli O157:H7 str. EDL933 960258 NP_290524.1 CDS fdhD NC_002655.2 4953416 4954249 D involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth; formate dehydrogenase accessory protein 4953416..4954249 Escherichia coli O157:H7 str. EDL933 960257 NP_290525.1 CDS yiiG NC_002655.2 4954402 4955457 D hypothetical protein 4954402..4955457 Escherichia coli O157:H7 str. EDL933 960256 NP_290526.1 CDS frvR NC_002655.2 4955507 4957255 R repressor of the frv operon, involved in phosphoenolpyruvate:sugar phosphotransferase system; frv operon regulatory protein complement(4955507..4957255) Escherichia coli O157:H7 str. EDL933 960255 NP_290527.1 CDS frvX NC_002655.2 4957255 4958325 R with FrvABR is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system which may be involved in the transport and phosphorylation of sugars; fructose-specific phosphotransferase system protein FrvX complement(4957255..4958325) Escherichia coli O157:H7 str. EDL933 960254 NP_290528.1 CDS frvB NC_002655.2 4958315 4959760 R PTS system transporter subunits IIBC complement(4958315..4959760) Escherichia coli O157:H7 str. EDL933 960253 NP_290529.1 CDS frvA NC_002655.2 4959765 4960211 R with FrvBRX is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system involved in the transport and phosphorylation of sugars; possibly responsible for the sugar specificity of the system; fructose-like phosphotransferase system subunit EIIA complement(4959765..4960211) Escherichia coli O157:H7 str. EDL933 960251 NP_290530.1 CDS Z5444 NC_002655.2 4960689 4962083 D glycoporin 4960689..4962083 Escherichia coli O157:H7 str. EDL933 960248 NP_290531.1 CDS yiiL NC_002655.2 4962124 4962438 R hypothetical protein complement(4962124..4962438) Escherichia coli O157:H7 str. EDL933 960247 NP_290532.1 CDS rhaD NC_002655.2 4962448 4963272 R rhamnulose-1-phosphate aldolase complement(4962448..4963272) Escherichia coli O157:H7 str. EDL933 960246 NP_290533.1 CDS rhaA NC_002655.2 4963447 4964706 R catalyzes the formation of L-rhamnulose from L-rhamnose; L-rhamnose isomerase complement(4963447..4964706) Escherichia coli O157:H7 str. EDL933 960245 NP_290534.1 CDS rhaB NC_002655.2 4964703 4966172 R catalyzes the ATP-dependent phosphorylation of rhamnulose; rhamnulokinase complement(4964703..4966172) Escherichia coli O157:H7 str. EDL933 960244 NP_290535.1 CDS rhaS NC_002655.2 4966460 4967296 D activates the expression of the rhaBAD operon and rhaT gene; transcriptional activator RhaS 4966460..4967296 Escherichia coli O157:H7 str. EDL933 960241 NP_290536.1 CDS rhaR NC_002655.2 4967280 4968218 D activates the expression of rhaRS in response to L-rhamnose; transcriptional activator RhaR 4967280..4968218 Escherichia coli O157:H7 str. EDL933 960240 NP_290537.1 CDS rhaT NC_002655.2 4968215 4969006 R rhamnose transport complement(4968215..4969006) Escherichia coli O157:H7 str. EDL933 960238 NP_290538.1 CDS sodA NC_002655.2 4969534 4970154 D SodA; manganese binding; only present under aerobic conditions; destroys free radicals; superoxide dismutase 4969534..4970154 Escherichia coli O157:H7 str. EDL933 960237 NP_290539.2 CDS kdgT NC_002655.2 4970414 4971397 D transports degraded pectin products into the bacterial cell; 2-keto-3-deoxygluconate permease 4970414..4971397 Escherichia coli O157:H7 str. EDL933 960236 NP_290540.2 CDS yiiM NC_002655.2 4971546 4972220 D hypothetical protein 4971546..4972220 Escherichia coli O157:H7 str. EDL933 960235 NP_290541.1 CDS cpxA NC_002655.2 4972326 4973699 R part of two-component CpxA/CpxR system; senses envelope stress; upregulates a number of periplasmic folding and trafficking factors; two-component sensor protein complement(4972326..4973699) Escherichia coli O157:H7 str. EDL933 960234 NP_290542.1 CDS cpxR NC_002655.2 4973696 4974394 R response regulator in two-component regulatory system with CpxA; part of the envelope stress response system; DNA-binding transcriptional regulator CpxR complement(4973696..4974394) Escherichia coli O157:H7 str. EDL933 960233 NP_290543.2 CDS cpxP NC_002655.2 4974544 4975044 D repressor of the Cpx envelope stress response pathway which occurs via periplasmic interactions with CpxA; CpxP is degraded by DegP protease especially in the presence of misfolded substrates; repressor CpxP 4974544..4975044 Escherichia coli O157:H7 str. EDL933 960232 NP_290544.1 CDS fieF NC_002655.2 4975193 4976095 D member of cation diffusion facilitator family; CDF; membrane-bound; induced by both zinc and iron, but does not induce resistance to zinc; can transport zinc(II) in a proton-dependent manner; instead this protein induces iron resistance; forms dimers; ferrous iron efflux protein F 4975193..4976095 Escherichia coli O157:H7 str. EDL933 960230 NP_290545.1 CDS pfkA NC_002655.2 4976276 4977238 D catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase 4976276..4977238 Escherichia coli O157:H7 str. EDL933 960228 NP_290546.1 CDS sbp NC_002655.2 4977557 4978546 D sulfate transporter subunit 4977557..4978546 Escherichia coli O157:H7 str. EDL933 960227 NP_290547.1 CDS cdh NC_002655.2 4978653 4979408 D CDP-diacylglycerol pyrophosphatase 4978653..4979408 Escherichia coli O157:H7 str. EDL933 960226 NP_290548.1 CDS tpiA NC_002655.2 4979463 4980230 R Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase complement(4979463..4980230) Escherichia coli O157:H7 str. EDL933 960224 NP_290549.1 CDS yiiQ NC_002655.2 4980338 4980937 R hypothetical protein complement(4980338..4980937) Escherichia coli O157:H7 str. EDL933 960223 NP_290550.1 CDS yiiR NC_002655.2 4981038 4981478 D hypothetical protein 4981038..4981478 Escherichia coli O157:H7 str. EDL933 960222 NP_290551.1 CDS yiiS NC_002655.2 4981690 4981989 D hypothetical protein 4981690..4981989 Escherichia coli O157:H7 str. EDL933 960220 NP_290552.1 CDS yiiT NC_002655.2 4982016 4982444 D with UspC and Usp E is involved in resistance to UV radiation; universal stress protein UspD 4982016..4982444 Escherichia coli O157:H7 str. EDL933 960217 NP_290553.1 CDS fpr NC_002655.2 4982449 4983195 R ferredoxin-NADP reductase complement(4982449..4983195) Escherichia coli O157:H7 str. EDL933 960215 NP_290554.1 CDS glpX NC_002655.2 4983292 4984302 R type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese; fructose 1,6-bisphosphatase II complement(4983292..4984302) Escherichia coli O157:H7 str. EDL933 960214 NP_290555.1 CDS glpK NC_002655.2 4984532 4986061 R Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase complement(4984532..4986061) Escherichia coli O157:H7 str. EDL933 960213 NP_290556.1 CDS glpF NC_002655.2 4986063 4986908 R facilitated diffusion of glycerol complement(4986063..4986908) Escherichia coli O157:H7 str. EDL933 960212 NP_290557.1 CDS yiiU NC_002655.2 4987334 4987579 D hypothetical protein 4987334..4987579 Escherichia coli O157:H7 str. EDL933 960211 NP_290558.1 CDS Z5474 NC_002655.2 4987618 4988334 R No significant matches; hypothetical protein complement(4987618..4988334) Escherichia coli O157:H7 str. EDL933 960210 NP_290559.1 CDS Z5475 NC_002655.2 4988367 4989053 R No significant matches; hypothetical protein complement(4988367..4989053) Escherichia coli O157:H7 str. EDL933 960209 NP_290560.1 CDS menG NC_002655.2 4989101 4989586 R regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity; ribonuclease activity regulator protein RraA complement(4989101..4989586) Escherichia coli O157:H7 str. EDL933 960208 NP_290561.1 CDS menA NC_002655.2 4989679 4990605 R catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate; 1,4-dihydroxy-2-naphthoate octaprenyltransferase complement(4989679..4990605) Escherichia coli O157:H7 str. EDL933 960207 NP_290562.1 CDS hslU NC_002655.2 4990672 4992003 R heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease ATP-binding subunit HslU complement(4990672..4992003) Escherichia coli O157:H7 str. EDL933 960206 NP_290563.1 CDS hslV NC_002655.2 4992013 4992543 R heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease peptidase subunit complement(4992013..4992543) Escherichia coli O157:H7 str. EDL933 960205 NP_290564.1 CDS ftsN NC_002655.2 4992636 4993595 R cell division protein FtsN complement(4992636..4993595) Escherichia coli O157:H7 str. EDL933 960204 NP_290565.1 CDS cytR NC_002655.2 4993687 4994712 R negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins; DNA-binding transcriptional regulator CytR complement(4993687..4994712) Escherichia coli O157:H7 str. EDL933 960203 NP_290566.1 CDS priA NC_002655.2 4994868 4997066 R binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA complement(4994868..4997066) Escherichia coli O157:H7 str. EDL933 960202 NP_290567.1 CDS rpmE NC_002655.2 4997269 4997481 D RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 4997269..4997481 Escherichia coli O157:H7 str. EDL933 960201 NP_290568.1 CDS Z5485 NC_002655.2 4997641 4998210 D hypothetical protein 4997641..4998210 Escherichia coli O157:H7 str. EDL933 960200 NP_290569.1 CDS Z5487 NC_002655.2 4998089 4998790 D hypothetical protein 4998089..4998790 Escherichia coli O157:H7 str. EDL933 960199 NP_290570.1 CDS Z5488 NC_002655.2 4998870 5001827 D hypothetical protein 4998870..5001827 Escherichia coli O157:H7 str. EDL933 960198 NP_290571.1 CDS Z5489 NC_002655.2 5001829 5002065 D hypothetical protein 5001829..5002065 Escherichia coli O157:H7 str. EDL933 960197 NP_290572.1 CDS Z5490 NC_002655.2 5002118 5002396 D No significant matches; hypothetical protein 5002118..5002396 Escherichia coli O157:H7 str. EDL933 960196 NP_290573.1 CDS Z5491 NC_002655.2 5002429 5002614 R hypothetical protein complement(5002429..5002614) Escherichia coli O157:H7 str. EDL933 960195 NP_290574.1 CDS yiiX NC_002655.2 5003058 5003666 R member of the NlpC/P60 superfamily of peptidases; peptidoglycan peptidase complement(5003058..5003666) Escherichia coli O157:H7 str. EDL933 960194 NP_290575.1 CDS metJ NC_002655.2 5003726 5004043 R when combined with S-adenosylmethionine represses the expression of the methionine regulon and of proteins involved in S-adenosylmethionine synthesis; transcriptional repressor protein MetJ complement(5003726..5004043) Escherichia coli O157:H7 str. EDL933 960193 NP_290576.1 CDS metB NC_002655.2 5004320 5005480 D catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; cystathionine gamma-synthase 5004320..5005480 Escherichia coli O157:H7 str. EDL933 960192 NP_290577.1 CDS metL NC_002655.2 5005483 5007915 D multifunctional homodimeric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways; bifunctional aspartate kinase II/homoserine dehydrogenase II 5005483..5007915 Escherichia coli O157:H7 str. EDL933 960191 NP_290578.1 CDS metF NC_002655.2 5008264 5009154 D MTHFR; catalyzes NADH-linked reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using FAD as a cofactor; 5,10-methylenetetrahydrofolate reductase 5008264..5009154 Escherichia coli O157:H7 str. EDL933 960190 NP_290579.1 CDS katG NC_002655.2 5009483 5011663 D catalase 5009483..5011663 Escherichia coli O157:H7 str. EDL933 960189 NP_290580.1 CDS yijE NC_002655.2 5011724 5012662 D hypothetical protein 5011724..5012662 Escherichia coli O157:H7 str. EDL933 960188 NP_290581.1 CDS yijF NC_002655.2 5012689 5013306 R hypothetical protein complement(5012689..5013306) Escherichia coli O157:H7 str. EDL933 960187 NP_290582.2 CDS gldA NC_002655.2 5013580 5014683 R forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone; glycerol dehydrogenase complement(5013580..5014683) Escherichia coli O157:H7 str. EDL933 960186 NP_290583.1 CDS talC NC_002655.2 5014694 5015356 R similar to transaldolase from Escherichia coli; many organisms have multiple copies; fructose-6-phosphate aldolase complement(5014694..5015356) Escherichia coli O157:H7 str. EDL933 960185 NP_290584.1 CDS ptsA NC_002655.2 5015368 5017503 R PEP-protein phosphotransferase system enzyme I complement(5015368..5017503) Escherichia coli O157:H7 str. EDL933 960184 NP_290585.1 CDS yijI NC_002655.2 5017505 5017969 D hypothetical protein 5017505..5017969 Escherichia coli O157:H7 str. EDL933 960183 NP_290586.1 CDS frwC NC_002655.2 5018178 5019257 D FrwC with FrwB, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; forms translocation channel and contains the specific substrate-binding site; fructose-like permease EIIC subunit 2 5018178..5019257 Escherichia coli O157:H7 str. EDL933 959634 NP_290587.1 CDS frwB NC_002655.2 5019272 5019592 D FrwB with FrwC, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system (PTS) permease which may phosphorylate and transport sugars into the cell; cytoplasmic protein that interacts with complex EIIA; contains the second phosphorylation site of the PTS; PTS system fructose-like transporter subunit EIIB 5019272..5019592 Escherichia coli O157:H7 str. EDL933 960182 NP_290588.1 CDS pflD NC_002655.2 5019643 5021940 D involved in production of D-lactate from glucose under microaerobic conditions; cytoplasmic protein; formate acetyltransferase 2 5019643..5021940 Escherichia coli O157:H7 str. EDL933 960181 NP_290589.1 CDS pflC NC_002655.2 5021906 5022784 D pyruvate formate lyase II activase 5021906..5022784 Escherichia coli O157:H7 str. EDL933 960180 NP_290590.1 CDS frwD NC_002655.2 5022786 5023127 D FrwD with FrwB, FrwC and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; phosphorylated by EIIA; FrwB homolog; fructose-like phosphotransferase EIIB subunit 3 5022786..5023127 Escherichia coli O157:H7 str. EDL933 960179 NP_290591.1 CDS yijO NC_002655.2 5023114 5023965 R AraC family transcriptional regulator complement(5023114..5023965) Escherichia coli O157:H7 str. EDL933 960178 NP_290592.1 CDS yijP NC_002655.2 5024180 5025913 R hypothetical protein complement(5024180..5025913) Escherichia coli O157:H7 str. EDL933 960177 NP_290593.1 CDS ppc NC_002655.2 5026096 5028747 R catalyzes the formation of oxaloacetate from phosphoenolpyruvate; phosphoenolpyruvate carboxylase complement(5026096..5028747) Escherichia coli O157:H7 str. EDL933 960176 NP_290594.1 CDS argE NC_002655.2 5029099 5030250 R catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine in arginine biosynthesis; acetylornithine deacetylase complement(5029099..5030250) Escherichia coli O157:H7 str. EDL933 960175 NP_290595.1 CDS argC NC_002655.2 5030404 5031408 D catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate; N-acetyl-gamma-glutamyl-phosphate reductase 5030404..5031408 Escherichia coli O157:H7 str. EDL933 960174 NP_290596.2 CDS argB NC_002655.2 5031419 5032192 D catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate; acetylglutamate kinase 5031419..5032192 Escherichia coli O157:H7 str. EDL933 960173 NP_290597.1 CDS argH NC_002655.2 5032253 5033626 D catalyzes the formation of arginine from (N-L-arginino)succinate; argininosuccinate lyase 5032253..5033626 Escherichia coli O157:H7 str. EDL933 960172 NP_290598.1 CDS oxyR NC_002655.2 5033893 5034810 D Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS, dps, fur and grxA; DNA-binding transcriptional regulator OxyR 5033893..5034810 Escherichia coli O157:H7 str. EDL933 960171 NP_290599.2 CDS udhA NC_002655.2 5034793 5036193 R catalyzes the conversion of NADPH to NADH; soluble pyridine nucleotide transhydrogenase complement(5034793..5036193) Escherichia coli O157:H7 str. EDL933 960170 NP_290600.1 CDS Z5522 NC_002655.2 5036523 5037689 D hippuricase 5036523..5037689 Escherichia coli O157:H7 str. EDL933 960169 NP_290601.1 CDS Z5523 NC_002655.2 5037732 5039048 D citrate permease 5037732..5039048 Escherichia coli O157:H7 str. EDL933 960168 NP_290602.1 CDS yijC NC_002655.2 5039098 5039802 D negatively controls the expression of fabA and fabB, genes involved in the unsaturated fatty acid biosynthesis; DNA-binding transcriptional repressor FabR 5039098..5039802 Escherichia coli O157:H7 str. EDL933 960167 NP_290603.1 CDS yijD NC_002655.2 5039802 5040161 D hypothetical protein 5039802..5040161 Escherichia coli O157:H7 str. EDL933 960166 NP_290604.1 CDS trmA NC_002655.2 5040201 5041301 R catalyzes the formation of 5-methyl-uridine at position 54 in all tRNAs; tRNA (uracil-5-)-methyltransferase complement(5040201..5041301) Escherichia coli O157:H7 str. EDL933 960165 NP_290605.1 CDS btuB NC_002655.2 5041670 5043514 D involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space; vitamin B12/cobalamin outer membrane transporter 5041670..5043514 Escherichia coli O157:H7 str. EDL933 960164 NP_290606.2 CDS murI NC_002655.2 5043459 5044316 D converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase 5043459..5044316 Escherichia coli O157:H7 str. EDL933 960163 NP_290607.1 CDS murB NC_002655.2 5049837 5050865 D catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase 5049837..5050865 Escherichia coli O157:H7 str. EDL933 960158 NP_290608.1 CDS birA NC_002655.2 5050862 5051827 D catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon; biotin--protein ligase 5050862..5051827 Escherichia coli O157:H7 str. EDL933 960157 NP_290609.1 CDS coaA NC_002655.2 5051856 5052782 R catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase complement(5051856..5052782) Escherichia coli O157:H7 str. EDL933 960156 NP_290610.1 CDS Z5547 NC_002655.2 5052976 5053131 R hypothetical protein complement(5052976..5053131) Escherichia coli O157:H7 str. EDL933 960155 NP_290611.1 CDS tuf NC_002655.2 5053707 5054891 D EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 5053707..5054891 Escherichia coli O157:H7 str. EDL933 960150 NP_290612.1 CDS secE NC_002655.2 5055121 5055504 D forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE 5055121..5055504 Escherichia coli O157:H7 str. EDL933 960149 NP_290613.1 CDS nusG NC_002655.2 5055506 5056051 D Modulates Rho-dependent transcription termination; transcription antitermination protein NusG 5055506..5056051 Escherichia coli O157:H7 str. EDL933 960148 NP_290614.1 CDS rplK NC_002655.2 5056210 5056638 D binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 5056210..5056638 Escherichia coli O157:H7 str. EDL933 960147 NP_290615.1 CDS rplA NC_002655.2 5056642 5057346 D in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 5056642..5057346 Escherichia coli O157:H7 str. EDL933 960146 NP_290616.1 CDS rplJ NC_002655.2 5057638 5058135 D binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 5057638..5058135 Escherichia coli O157:H7 str. EDL933 960145 NP_290617.1 CDS rplL NC_002655.2 5058202 5058567 D present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 5058202..5058567 Escherichia coli O157:H7 str. EDL933 960144 NP_290618.1 CDS rpoB NC_002655.2 5058887 5062915 D DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 5058887..5062915 Escherichia coli O157:H7 str. EDL933 960143 NP_290619.1 CDS rpoC NC_002655.2 5062992 5067215 D DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' 5062992..5067215 Escherichia coli O157:H7 str. EDL933 960142 NP_290620.1 CDS htrC NC_002655.2 5067428 5067871 D heat shock protein C 5067428..5067871 Escherichia coli O157:H7 str. EDL933 960141 NP_290621.1 CDS thiH NC_002655.2 5068306 5069439 R in Escherichia coli this enzyme functions in thiamine biosynthesis along with thiFSGI and iscS; with ThiFSG catalyzes the formation of thiazole phosphate from tyrosine, cysteine and 1-deoxy-D-xylulose-5-phosphate; forms a complex with ThiG; contains an iron-sulfur center; thiamine biosynthesis protein ThiH complement(5068306..5069439) Escherichia coli O157:H7 str. EDL933 960140 NP_290622.2 CDS thiG NC_002655.2 5069436 5070206 R functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate; thiazole synthase complement(5069436..5070206) Escherichia coli O157:H7 str. EDL933 960139 NP_290623.2 CDS thiS NC_002655.2 5070208 5070408 R with ThiF, ThiG, and ThiO catalyzes the formation of the thiazole moiety of thiamine pyrophosphate; sulfur carrier protein ThiS complement(5070208..5070408) Escherichia coli O157:H7 str. EDL933 960138 NP_290624.2 CDS thiF NC_002655.2 5070392 5071147 R catalyzes the adenylation of ThiS which is involved in the formation of 5-methyl-4-(beta-hydroxyethyl)thiazole phosphate; thiamine biosynthesis protein ThiF complement(5070392..5071147) Escherichia coli O157:H7 str. EDL933 960137 NP_290625.1 CDS thiE NC_002655.2 5071140 5071775 R catalyzes the formation of thiamine monophosphate from 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate; thiamine-phosphate pyrophosphorylase complement(5071140..5071775) Escherichia coli O157:H7 str. EDL933 960136 NP_290626.1 CDS thiC NC_002655.2 5071775 5073670 R required for the synthesis of the hydromethylpyrimidine moiety of thiamine; thiamine biosynthesis protein ThiC complement(5071775..5073670) Escherichia coli O157:H7 str. EDL933 960135 NP_290627.1 CDS yjaE NC_002655.2 5073903 5074379 R binds specifically to the major sigma factor sigma 70; active in stationary phase; anti-RNA polymerase sigma 70 factor complement(5073903..5074379) Escherichia coli O157:H7 str. EDL933 960134 NP_290628.1 CDS nudC NC_002655.2 5074474 5075247 D can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates; NADH pyrophosphatase 5074474..5075247 Escherichia coli O157:H7 str. EDL933 960133 NP_290629.1 CDS hemE NC_002655.2 5075287 5076351 D catalyzes the formation of coproporphyrinogen from uroporphyrinogen III; uroporphyrinogen decarboxylase 5075287..5076351 Escherichia coli O157:H7 str. EDL933 960132 NP_290630.1 CDS nfi NC_002655.2 5076361 5077032 D Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA; cleaves DNA containing urea residues, AP sites, base mismatches, insertion/deletion mismatches, flaps, and pseudo-Y structures; endonuclease V 5076361..5077032 Escherichia coli O157:H7 str. EDL933 960131 NP_290631.1 CDS yjaG NC_002655.2 5077075 5077665 D hypothetical protein 5077075..5077665 Escherichia coli O157:H7 str. EDL933 960130 NP_290632.1 CDS hupA NC_002655.2 5077852 5078124 D histone-like DNA-binding protein; transcriptional regulator HU subunit alpha 5077852..5078124 Escherichia coli O157:H7 str. EDL933 960129 NP_290633.1 CDS yjaH NC_002655.2 5078137 5078832 D hypothetical protein 5078137..5078832 Escherichia coli O157:H7 str. EDL933 960128 NP_290634.2 CDS zraP NC_002655.2 5078834 5079259 R zinc resistance protein complement(5078834..5079259) Escherichia coli O157:H7 str. EDL933 960127 NP_290635.1 CDS hydH NC_002655.2 5079497 5080873 D sensor protein ZraS 5079497..5080873 Escherichia coli O157:H7 str. EDL933 960126 NP_290636.1 CDS hydG NC_002655.2 5080870 5082195 D DNA-binding response regulator in two-component regulatory system with ZraS; response regulator/sigma54 interaction protein; transcriptional regulatory protein ZraR 5080870..5082195 Escherichia coli O157:H7 str. EDL933 960125 NP_290637.1 CDS purD NC_002655.2 5082192 5083481 R catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase complement(5082192..5083481) Escherichia coli O157:H7 str. EDL933 960124 NP_290638.1 CDS purH NC_002655.2 5083493 5085082 R involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase complement(5083493..5085082) Escherichia coli O157:H7 str. EDL933 960123 NP_290639.1 CDS yjaB NC_002655.2 5090824 5091267 R hypothetical protein complement(5090824..5091267) Escherichia coli O157:H7 str. EDL933 960118 NP_290640.1 CDS metA NC_002655.2 5091424 5092353 D catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis; homoserine O-succinyltransferase 5091424..5092353 Escherichia coli O157:H7 str. EDL933 960117 NP_290641.1 CDS aceB NC_002655.2 5092622 5094223 D Catalyzes the aldol condensation of glyoxylate with acetyl-CoA to form malate as part of the second step of the glyoxylate bypass and an alternative to the tricarboxylic acid cycle; malate synthase 5092622..5094223 Escherichia coli O157:H7 str. EDL933 960116 NP_290642.1 CDS aceA NC_002655.2 5094238 5095557 D Catalyzes the first step in the glyoxalate cycle, which converts lipids to carbohydrates; isocitrate lyase 5094238..5095557 Escherichia coli O157:H7 str. EDL933 960115 NP_290643.1 CDS aceK NC_002655.2 5095741 5097477 D catalyzes the phosphorylation/dephosphorylation of the enzyme isocitrate dehydrogenase on a specific serine which regulates activity; unphosphorylated IDH is fully active when cells are grown on glucose while the enzyme becomes phosphorylated and inactive in the presence of acetate or ethanol; bifunctional isocitrate dehydrogenase kinase/phosphatase 5095741..5097477 Escherichia coli O157:H7 str. EDL933 960114 NP_290644.1 CDS arp NC_002655.2 5097446 5099632 R regulator of acetyl CoA synthetase complement(5097446..5099632) Escherichia coli O157:H7 str. EDL933 960113 NP_290645.2 CDS iclR NC_002655.2 5099950 5100774 R regulates the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase and isocitrate dehydrogenase kinase/phosphorylase; IclR family transcriptional regulator complement(5099950..5100774) Escherichia coli O157:H7 str. EDL933 960112 NP_290646.1 CDS metH NC_002655.2 5100974 5104657 D one of two methionine synthases in Escherichia coli; MetH catalyzes a methyl transfer reaction from methyltetrahydrofolate to homocysteine to create methionine; requires zinc for activity; B12-dependent methionine synthase 5100974..5104657 Escherichia coli O157:H7 str. EDL933 960111 NP_290647.1 CDS yjbB NC_002655.2 5104877 5106508 D alpha helix protein 5104877..5106508 Escherichia coli O157:H7 str. EDL933 960110 NP_290648.1 CDS pepE NC_002655.2 5106599 5107288 R alpha-aspartyl dipeptidase; catalyzes the hydrolysis of dipeptides with an N-terminal aspartate residue; belongs to peptidase S51 family; peptidase E complement(5106599..5107288) Escherichia coli O157:H7 str. EDL933 960109 NP_290649.1 CDS Z5613 NC_002655.2 5107671 5108912 R L-sorbose-1-P-reductase complement(5107671..5108912) Escherichia coli O157:H7 str. EDL933 960108 NP_290650.1 CDS Z5614 NC_002655.2 5108952 5109776 R sorbose PTS component complement(5108952..5109776) Escherichia coli O157:H7 str. EDL933 960107 NP_290651.1 CDS Z5615 NC_002655.2 5109787 5110584 R sorbose PTS component complement(5109787..5110584) Escherichia coli O157:H7 str. EDL933 960106 NP_290652.1 CDS Z5616 NC_002655.2 5110650 5111144 R sorbose PTS component complement(5110650..5111144) Escherichia coli O157:H7 str. EDL933 960105 NP_290653.1 CDS Z5617 NC_002655.2 5111144 5111551 R sorbose PTS component complement(5111144..5111551) Escherichia coli O157:H7 str. EDL933 960104 NP_290654.1 CDS Z5618 NC_002655.2 5111561 5112367 R Converts D-sorbitol-dphosphate to D-fructose-6-phosphate; sorbitol-6-phosphate 2-dehydrogenase complement(5111561..5112367) Escherichia coli O157:H7 str. EDL933 960103 NP_290655.1 CDS Z5619 NC_002655.2 5112437 5113405 R transcriptional regulator of sorbose uptake and utilization genes complement(5112437..5113405) Escherichia coli O157:H7 str. EDL933 960102 NP_290656.1 CDS yjbC NC_002655.2 5113732 5114604 D catalyzes the synthesis of pseudouridine from U-2604 in the 23S ribosomal RNA; 23S rRNA pseudouridine synthase F 5113732..5114604 Escherichia coli O157:H7 str. EDL933 960101 NP_290657.1 CDS yjbD NC_002655.2 5114605 5114877 R hypothetical protein complement(5114605..5114877) Escherichia coli O157:H7 str. EDL933 960100 NP_290658.1 CDS lysC NC_002655.2 5115130 5116479 R catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; functions in amino acid biosynthesis; lysine sensitive; aspartate kinase complement(5115130..5116479) Escherichia coli O157:H7 str. EDL933 960099 NP_290659.1 CDS pgi NC_002655.2 5117004 5118653 D functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase 5117004..5118653 Escherichia coli O157:H7 str. EDL933 960098 NP_290660.1 CDS yjbE NC_002655.2 5119166 5119408 D hypothetical protein 5119166..5119408 Escherichia coli O157:H7 str. EDL933 960097 NP_290661.1 CDS yjbF NC_002655.2 5119492 5120160 D hypothetical protein 5119492..5120160 Escherichia coli O157:H7 str. EDL933 960096 NP_290662.1 CDS yjbG NC_002655.2 5120157 5120894 D hypothetical protein 5120157..5120894 Escherichia coli O157:H7 str. EDL933 960095 NP_290663.1 CDS yjbH NC_002655.2 5120894 5122990 D hypothetical protein 5120894..5122990 Escherichia coli O157:H7 str. EDL933 960094 NP_290664.1 CDS yjbA NC_002655.2 5123585 5123995 D phosphate-starvation-inducible protein PsiE 5123585..5123995 Escherichia coli O157:H7 str. EDL933 960093 NP_290665.1 CDS xylE NC_002655.2 5124039 5125514 R xylose/proton symporter; member of the major facilitator superfamily (MFS) of transporter; D-xylose transporter XylE complement(5124039..5125514) Escherichia coli O157:H7 str. EDL933 960092 NP_290666.1 CDS malG NC_002655.2 5125886 5126776 R with MalKFE is involved in the transport of maltose into the cell; maltose ABC transporter permease complement(5125886..5126776) Escherichia coli O157:H7 str. EDL933 960091 NP_290667.1 CDS malF NC_002655.2 5126791 5128335 R with MalKGE is involved in maltose transport into the cell; maltose transporter membrane protein complement(5126791..5128335) Escherichia coli O157:H7 str. EDL933 960090 NP_290668.1 CDS malE NC_002655.2 5128489 5129679 R functions in the MalKFGE ABC transporter complex to transport maltose into the cell by using ATP hydrolysis; maltose ABC transporter substrate-binding protein complement(5128489..5129679) Escherichia coli O157:H7 str. EDL933 960089 NP_290669.1 CDS malK NC_002655.2 5130044 5131159 D with malEFG is involved in import of maltose/maltodextrin; maltose ABC transporter ATP-binding protein 5130044..5131159 Escherichia coli O157:H7 str. EDL933 960088 NP_290670.1 CDS lamB NC_002655.2 5131231 5132571 D porin involved in the transport of maltose and maltodextrins; maltoporin 5131231..5132571 Escherichia coli O157:H7 str. EDL933 960087 NP_290671.1 CDS malM NC_002655.2 5132722 5133642 D maltose regulon periplasmic protein 5132722..5133642 Escherichia coli O157:H7 str. EDL933 960086 NP_290672.1 CDS yjbI NC_002655.2 5133871 5135451 D in E. coli, some yjbl mutations have been reported as suppressors of dnaG mutations; hypothetical protein 5133871..5135451 Escherichia coli O157:H7 str. EDL933 960085 NP_290673.2 CDS ubiC NC_002655.2 5135674 5136171 D catalyzes the formation of 4-hydroxybenzoate from chorismate; chorismate pyruvate lyase 5135674..5136171 Escherichia coli O157:H7 str. EDL933 960084 NP_290674.1 CDS ubiA NC_002655.2 5136184 5137056 D catalyzes the conversion of 4-Hydroxybenzoate into 3-octaprenyl-4-hydroxybenzoate, as part of the ubiquinone biosynthesis pathway; 4-hydroxybenzoate octaprenyltransferase 5136184..5137056 Escherichia coli O157:H7 str. EDL933 960083 NP_290675.2 CDS plsB NC_002655.2 5137211 5139634 R PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA; glycerol-3-phosphate acyltransferase complement(5137211..5139634) Escherichia coli O157:H7 str. EDL933 960082 NP_290676.1 CDS dgkA NC_002655.2 5139805 5140173 D diacylglycerol kinase 5139805..5140173 Escherichia coli O157:H7 str. EDL933 960081 NP_290677.1 CDS lexA NC_002655.2 5140283 5140891 D Represses a number of genes involved in the response to DNA damage; LexA repressor 5140283..5140891 Escherichia coli O157:H7 str. EDL933 960080 NP_290678.2 CDS dinF NC_002655.2 5140964 5142289 D DNA-damage-inducible SOS response protein 5140964..5142289 Escherichia coli O157:H7 str. EDL933 960079 NP_290679.1 CDS yjbJ NC_002655.2 5142405 5142614 D unknown function; highly abundant protein in vivo; overexpressed under high NaCl concentrations; part of the sigma S regulon; non-essential; stress-response protein 5142405..5142614 Escherichia coli O157:H7 str. EDL933 960078 NP_290680.2 CDS yjbK NC_002655.2 5142656 5143171 R Acts as a negative controlling element, employing Zn(2+) as a cofactor to bind the operator of the repressed genes znuACB; zinc uptake transcriptional repressor complement(5142656..5143171) Escherichia coli O157:H7 str. EDL933 960077 NP_290681.1 CDS Z5646 NC_002655.2 5143490 5144446 D hypothetical protein 5143490..5144446 Escherichia coli O157:H7 str. EDL933 960076 NP_290682.1 CDS yjbN NC_002655.2 5144808 5145845 D tRNA-dihydrouridine synthase A 5144808..5145845 Escherichia coli O157:H7 str. EDL933 960075 NP_290683.2 CDS pspG NC_002655.2 5145979 5146221 D coordinately regulated along with pspA; PspF-dependent induction in response to secretin overexpression in Yersinia; phage shock protein G 5145979..5146221 Escherichia coli O157:H7 str. EDL933 960074 NP_290684.1 CDS qor NC_002655.2 5146387 5147370 R quinone oxidoreductase complement(5146387..5147370) Escherichia coli O157:H7 str. EDL933 960073 NP_290685.1 CDS dnaB NC_002655.2 5147453 5148868 D unwinds double stranded DNA; replicative DNA helicase 5147453..5148868 Escherichia coli O157:H7 str. EDL933 960072 NP_290686.1 CDS alr NC_002655.2 5148921 5150000 D converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase 5148921..5150000 Escherichia coli O157:H7 str. EDL933 960071 NP_290687.1 CDS tyrB NC_002655.2 5150253 5151446 D catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate; aromatic amino acid aminotransferase 5150253..5151446 Escherichia coli O157:H7 str. EDL933 960070 NP_290688.1 CDS aphA NC_002655.2 5152545 5153258 D Class B; non-specific; catalyzes the dephosphorylation of organic phosphomonoesters; also has phosphotransferase activity; acid phosphatase/phosphotransferase 5152545..5153258 Escherichia coli O157:H7 str. EDL933 960069 NP_290689.1 CDS yjbQ NC_002655.2 5153369 5153785 D hypothetical protein 5153369..5153785 Escherichia coli O157:H7 str. EDL933 960068 NP_290690.1 CDS yjbR NC_002655.2 5153789 5154145 D hypothetical protein 5153789..5154145 Escherichia coli O157:H7 str. EDL933 960067 NP_290691.1 CDS uvrA NC_002655.2 5154180 5157002 R The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A complement(5154180..5157002) Escherichia coli O157:H7 str. EDL933 960066 NP_290692.1 CDS ssb NC_002655.2 5157257 5157793 D binds to single stranded DNA and PriA helcase facilitate replication restart; single-stranded DNA-binding protein 5157257..5157793 Escherichia coli O157:H7 str. EDL933 960065 NP_290693.1 CDS yjcB NC_002655.2 5157892 5158242 R hypothetical protein complement(5157892..5158242) Escherichia coli O157:H7 str. EDL933 960064 NP_290694.1 CDS yjcC NC_002655.2 5158602 5160188 D hypothetical protein 5158602..5160188 Escherichia coli O157:H7 str. EDL933 960063 NP_290695.1 CDS soxS NC_002655.2 5160191 5160514 R regulates genes involved in response to oxidative stress; DNA-binding transcriptional regulator SoxS complement(5160191..5160514) Escherichia coli O157:H7 str. EDL933 960062 NP_290696.1 CDS soxR NC_002655.2 5160600 5161064 D redox-sensitive transcriptional activator SoxR 5160600..5161064 Escherichia coli O157:H7 str. EDL933 960061 NP_290697.1 CDS yjcD NC_002655.2 5161610 5162959 D hypothetical protein 5161610..5162959 Escherichia coli O157:H7 str. EDL933 960060 NP_290698.1 CDS yjcE NC_002655.2 5163110 5164759 D hypothetical protein 5163110..5164759 Escherichia coli O157:H7 str. EDL933 960059 NP_290699.1 CDS yjcF NC_002655.2 5164913 5166205 R hypothetical protein complement(5164913..5166205) Escherichia coli O157:H7 str. EDL933 960058 NP_290700.1 CDS actP NC_002655.2 5166386 5168035 R member of the sodium:solute symporter family; cotranscribed with the acs gene which encodes acetyl coenzyme A synthase; mutations affect acetate uptake; acetate permease complement(5166386..5168035) Escherichia coli O157:H7 str. EDL933 960057 NP_290701.1 CDS yjcH NC_002655.2 5168032 5168346 R hypothetical protein complement(5168032..5168346) Escherichia coli O157:H7 str. EDL933 960056 NP_290702.1 CDS acs NC_002655.2 5168547 5170505 R Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA; acetyl-CoA synthetase complement(5168547..5170505) Escherichia coli O157:H7 str. EDL933 960055 NP_290703.1 CDS nrfA NC_002655.2 5170898 5172334 D catalyzes the formate-dependent reduction of nitrite to ammonia; cytochrome C552; cytochrome c552 5170898..5172334 Escherichia coli O157:H7 str. EDL933 960054 NP_290704.1 CDS nrfB NC_002655.2 5172373 5172945 D part of nitrite reductase complex; NrfB is active at high nitrate conditions; NrfA, B, C, and D are essential for the formate-dependent nitrite reduction to ammonia; cytochrome c nitrite reductase pentaheme subunit 5172373..5172945 Escherichia coli O157:H7 str. EDL933 960053 NP_290705.1 CDS nrfC NC_002655.2 5172942 5173613 D formate-dependent nitrite reductase; Fe-S centers 5172942..5173613 Escherichia coli O157:H7 str. EDL933 960052 NP_290706.1 CDS nrfD NC_002655.2 5173610 5174566 D formate-dependent nitrate reductase complex; transmembrane protein 5173610..5174566 Escherichia coli O157:H7 str. EDL933 960051 NP_290707.1 CDS nrfE NC_002655.2 5174646 5176304 D with NrfF and NrfG catalyzes the insertion of heme into cytochrome c552; heme lyase subunit NrfE 5174646..5176304 Escherichia coli O157:H7 str. EDL933 960050 NP_290708.1 CDS nrfF NC_002655.2 5176297 5176680 D formate-dependent nitrite reductase complex subunit NrfF 5176297..5176680 Escherichia coli O157:H7 str. EDL933 960049 NP_290709.1 CDS nrfG NC_002655.2 5176677 5177273 D formate-dependent nitrite reductase complex subunit NrfG 5176677..5177273 Escherichia coli O157:H7 str. EDL933 960048 NP_290710.1 CDS gltP NC_002655.2 5177615 5178928 D carrier protein part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system; glutamate/aspartate:proton symporter 5177615..5178928 Escherichia coli O157:H7 str. EDL933 960047 NP_290711.1 CDS yjcO NC_002655.2 5179106 5179795 R hypothetical protein complement(5179106..5179795) Escherichia coli O157:H7 str. EDL933 960046 NP_290712.1 CDS fdhF NC_002655.2 5179889 5182036 R formate dehydrogenase complement(5179889..5182036) Escherichia coli O157:H7 str. EDL933 960045 NP_290713.1 CDS yjcP NC_002655.2 5182234 5183700 R part of a multidrug efflux system involved in resistance to acriflavin, puromycin, erytjhromycin and tetraphenylarsonium chloride; member of the outer membrane factor (OMF) family; outer membrane efflux protein MdtP complement(5182234..5183700) Escherichia coli O157:H7 str. EDL933 960044 NP_290714.2 CDS yjcQ NC_002655.2 5183697 5185748 R possibly part of a tripartite efflux system composed of MdtN, MdtO and MdtP which could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; multidrug efflux system protein MdtO complement(5183697..5185748) Escherichia coli O157:H7 str. EDL933 960043 NP_290715.1 CDS yjcR NC_002655.2 5185748 5186779 R with MdtO and MdtP is involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; multidrug resistance protein MdtN complement(5185748..5186779) Escherichia coli O157:H7 str. EDL933 960042 NP_290716.1 CDS yjcS NC_002655.2 5187282 5189279 R hypothetical protein complement(5187282..5189279) Escherichia coli O157:H7 str. EDL933 960041 NP_290717.1 CDS Z5684 NC_002655.2 5189540 5190265 D transcriptional regulator 5189540..5190265 Escherichia coli O157:H7 str. EDL933 960040 NP_290718.1 CDS Z5686 NC_002655.2 5190262 5191263 R kinase complement(5190262..5191263) Escherichia coli O157:H7 str. EDL933 960039 NP_290719.1 CDS Z5687 NC_002655.2 5191260 5192120 R hypothetical protein complement(5191260..5192120) Escherichia coli O157:H7 str. EDL933 960038 NP_290720.1 CDS Z5688 NC_002655.2 5192135 5192818 R No significant matches; hypothetical protein complement(5192135..5192818) Escherichia coli O157:H7 str. EDL933 960037 NP_290721.1 CDS Z5689 NC_002655.2 5192873 5193814 R ABC transporter substrate-binding protein complement(5192873..5193814) Escherichia coli O157:H7 str. EDL933 960036 NP_290722.1 CDS Z5690 NC_002655.2 5193833 5194807 R permease of ribose ABC transport system complement(5193833..5194807) Escherichia coli O157:H7 str. EDL933 960035 NP_290723.1 CDS Z5691 NC_002655.2 5194804 5196357 R ribose ABC transporter ATP-binding protein complement(5194804..5196357) Escherichia coli O157:H7 str. EDL933 960034 NP_290724.1 CDS Z5692 NC_002655.2 5196438 5198708 D histidine kinase 5196438..5198708 Escherichia coli O157:H7 str. EDL933 960033 NP_290725.1 CDS Z5694 NC_002655.2 5198777 5199106 D hypothetical protein 5198777..5199106 Escherichia coli O157:H7 str. EDL933 960032 NP_290726.1 CDS phnP NC_002655.2 5199183 5199941 R required for the use of phosphonates and phosphite as phosphorus sources; carbon-phosphorus lyase complex accessory protein complement(5199183..5199941) Escherichia coli O157:H7 str. EDL933 960031 NP_290727.1 CDS phnO NC_002655.2 5199943 5200272 R PhnO in Salmonella enterica catalyzes the acetylation of a range of aminoalkylphosphonic acids; part of the biochemical pathway that enables the cell to use phosphonates as a phosphorus source; Escherichia coli uses a different mechanism of phosphonate catabolism where PhnO is not essential and seems to play a regulatory role; aminoalkylphosphonic acid N-acetyltransferase complement(5199943..5200272) Escherichia coli O157:H7 str. EDL933 960030 NP_290728.1 CDS phnN NC_002655.2 5200365 5200922 R ribose 1,5-bisphosphokinase complement(5200365..5200922) Escherichia coli O157:H7 str. EDL933 960029 NP_290729.1 CDS phnM NC_002655.2 5200922 5202058 R phosphonate metabolism protein complement(5200922..5202058) Escherichia coli O157:H7 str. EDL933 960028 NP_290730.1 CDS phnL NC_002655.2 5202055 5202735 R phosphonate ABC transporter ATP-binding protein complement(5202055..5202735) Escherichia coli O157:H7 str. EDL933 960027 NP_290731.1 CDS phnK NC_002655.2 5202846 5203604 R phosphonate C-P lyase system protein PhnK complement(5202846..5203604) Escherichia coli O157:H7 str. EDL933 960026 NP_290732.1 CDS phnJ NC_002655.2 5203601 5204446 R phosphonate metabolism protein complement(5203601..5204446) Escherichia coli O157:H7 str. EDL933 960025 NP_290733.1 CDS phnI NC_002655.2 5204439 5205503 R phosphonate metabolism protein complement(5204439..5205503) Escherichia coli O157:H7 str. EDL933 960024 NP_290734.1 CDS phnH NC_002655.2 5205503 5206087 R carbon-phosphorus lyase complex subunit complement(5205503..5206087) Escherichia coli O157:H7 str. EDL933 960023 NP_290735.1 CDS phnG NC_002655.2 5206084 5206536 R phosphonate metabolism protein complement(5206084..5206536) Escherichia coli O157:H7 str. EDL933 960022 NP_290736.1 CDS phnF NC_002655.2 5206537 5207262 R may be involved in phosphonate uptake and biodegradation; phosphonate metabolism transcriptional regulator PhnF complement(5206537..5207262) Escherichia coli O157:H7 str. EDL933 960021 NP_290737.1 CDS phnE NC_002655.2 5207283 5208113 R membrane channel protein component of Pn transporter complement(5207283..5208113) Escherichia coli O157:H7 str. EDL933 960020 NP_290738.1 CDS phnD NC_002655.2 5208168 5209184 R periplasmic binding protein component of Pn transporter complement(5208168..5209184) Escherichia coli O157:H7 str. EDL933 960019 NP_290739.1 CDS phnC NC_002655.2 5209209 5209997 R phosphonate/organophosphate ester transporter subunit complement(5209209..5209997) Escherichia coli O157:H7 str. EDL933 960018 NP_290740.1 CDS phnB NC_002655.2 5210130 5210573 R hypothetical protein complement(5210130..5210573) Escherichia coli O157:H7 str. EDL933 960017 NP_290741.1 CDS phnA NC_002655.2 5210832 5211167 R hypothetical protein complement(5210832..5211167) Escherichia coli O157:H7 str. EDL933 960016 NP_290742.1 CDS yjdA NC_002655.2 5211569 5213797 D hypothetical protein 5211569..5213797 Escherichia coli O157:H7 str. EDL933 960015 NP_290743.1 CDS yjcZ NC_002655.2 5213827 5214672 D hypothetical protein 5213827..5214672 Escherichia coli O157:H7 str. EDL933 960014 NP_290744.1 CDS proP NC_002655.2 5214936 5216438 D proline/glycine betaine transporter 5214936..5216438 Escherichia coli O157:H7 str. EDL933 960013 NP_290745.1 CDS basS NC_002655.2 5216615 5217706 R sensor protein BasS/PmrB complement(5216615..5217706) Escherichia coli O157:H7 str. EDL933 960012 NP_290746.1 CDS basR NC_002655.2 5217716 5218384 R response regulator in two-component regulatory system with BasS; DNA-binding transcriptional regulator BasR complement(5217716..5218384) Escherichia coli O157:H7 str. EDL933 960011 NP_290747.1 CDS yjdB NC_002655.2 5218381 5220054 R with ZipA and an unidentified 24 kDa protein forms a complex involved in cell division; cell division protein complement(5218381..5220054) Escherichia coli O157:H7 str. EDL933 960010 NP_290748.1 CDS yjdE NC_002655.2 5220128 5221465 R arginine:agmatin antiporter complement(5220128..5221465) Escherichia coli O157:H7 str. EDL933 960009 NP_290749.1 CDS adiY NC_002655.2 5221602 5222363 R AraC family transcriptional regulator complement(5221602..5222363) Escherichia coli O157:H7 str. EDL933 960008 NP_290750.1 CDS adiA NC_002655.2 5222688 5224958 R biodegradative arginine decarboxylase complement(5222688..5224958) Escherichia coli O157:H7 str. EDL933 960007 NP_290751.1 CDS melR NC_002655.2 5225154 5226062 R DNA-binding transcriptional regulator MelR complement(5225154..5226062) Escherichia coli O157:H7 str. EDL933 960006 NP_290752.1 CDS melA NC_002655.2 5226345 5227700 D alpha-galactosidase 5226345..5227700 Escherichia coli O157:H7 str. EDL933 960005 NP_290753.1 CDS melB NC_002655.2 5227815 5229224 D melibiose:sodium symporter 5227815..5229224 Escherichia coli O157:H7 str. EDL933 960004 NP_290754.1 CDS yjdF NC_002655.2 5229363 5229992 R hypothetical protein complement(5229363..5229992) Escherichia coli O157:H7 str. EDL933 960003 NP_290755.1 CDS fumB NC_002655.2 5230115 5231761 R fumarase B complement(5230115..5231761) Escherichia coli O157:H7 str. EDL933 960002 NP_290756.1 CDS dcuB NC_002655.2 5231839 5233179 R functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to DcuA; DcuA and DcuB function as independent and mutually redundant C4-dicarboxylate (aspartate, malate, fumarate and succinate) transporters; anaerobic C4-dicarboxylate transporter complement(5231839..5233179) Escherichia coli O157:H7 str. EDL933 960001 NP_290757.1 CDS yjdG NC_002655.2 5233750 5234469 R response regulator in two-component regulatory system with DcuS; phosphorylated DcuR activates transcription of genes involved in anaerobic fumarate respiration; DNA-binding transcriptional activator DcuR complement(5233750..5234469) Escherichia coli O157:H7 str. EDL933 960000 NP_290758.1 CDS yjdH NC_002655.2 5234466 5236097 R C4-dicarboxylate-sensing histidine kinase; part of two-component regulatory system with DcuR; regulates anaerobic fumarate respiration; sensory histidine kinase DcuS complement(5234466..5236097) Escherichia coli O157:H7 str. EDL933 959999 NP_290759.1 CDS yjdI NC_002655.2 5236278 5236508 D hypothetical protein 5236278..5236508 Escherichia coli O157:H7 str. EDL933 959998 NP_290760.1 CDS yjdJ NC_002655.2 5236520 5236792 D hypothetical protein 5236520..5236792 Escherichia coli O157:H7 str. EDL933 959997 NP_290761.1 CDS yjdK NC_002655.2 5237019 5237315 D hypothetical protein 5237019..5237315 Escherichia coli O157:H7 str. EDL933 959996 NP_290762.1 CDS Z5731 NC_002655.2 5237343 5237516 D hypothetical protein 5237343..5237516 Escherichia coli O157:H7 str. EDL933 959995 NP_290763.1 CDS lysS NC_002655.2 5237635 5239152 R class II; inducible; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; induced by high temperature, anaerobiosis, and low pH; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase complement(5237635..5239152) Escherichia coli O157:H7 str. EDL933 959994 NP_290764.1 CDS yjdL NC_002655.2 5239389 5240846 R peptide transporter complement(5239389..5240846) Escherichia coli O157:H7 str. EDL933 959993 NP_290765.1 CDS cadA NC_002655.2 5240905 5243052 R lysine decarboxylase 1 complement(5240905..5243052) Escherichia coli O157:H7 str. EDL933 959992 NP_290766.1 CDS cadB NC_002655.2 5243132 5244466 R antiporter protein responsible for lysine import and cadaverine export; member of the lysine-dependent acid resistance system 4 (AR4); inner membrane protein; lysine/cadaverine antiporter complement(5243132..5244466) Escherichia coli O157:H7 str. EDL933 959991 NP_290767.1 CDS cadC NC_002655.2 5244832 5246370 R regulates the cadBA operon; DNA-binding transcriptional activator CadC complement(5244832..5246370) Escherichia coli O157:H7 str. EDL933 959990 NP_290768.1 CDS yjdC NC_002655.2 5247169 5247768 R transcriptional regulator complement(5247169..5247768) Escherichia coli O157:H7 str. EDL933 959988 NP_290769.1 CDS dipZ NC_002655.2 5247781 5249478 R two electrons are transferred from cytoplasmic NADPH to thioredoxin and then to the inner membrane protein DsbD which keeps the disulfide isomerase DsbC in a reduced state in the oxidizing periplasm; DsbC in turns rearranges incorrectly made disulfide bonds in the periplasm; thiol:disulfide interchange protein complement(5247781..5249478) Escherichia coli O157:H7 str. EDL933 959987 NP_290770.1 CDS cutA NC_002655.2 5249454 5249792 R copper binding protein required for copper tolerance; involved in resistance toward heavy metals; divalent-cation tolerance protein CutA complement(5249454..5249792) Escherichia coli O157:H7 str. EDL933 959986 NP_290771.1 CDS dcuA NC_002655.2 5249908 5251209 R functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB; anaerobic C4-dicarboxylate transporter complement(5249908..5251209) Escherichia coli O157:H7 str. EDL933 959985 NP_290772.1 CDS aspA NC_002655.2 5251327 5252808 R catalyzes the formation of fumarate from aspartate; aspartate ammonia-lyase complement(5251327..5252808) Escherichia coli O157:H7 str. EDL933 959984 NP_290773.2 CDS fxsA NC_002655.2 5253100 5253576 D F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein; FxsA protein 5253100..5253576 Escherichia coli O157:H7 str. EDL933 959983 NP_290774.1 CDS yjeH NC_002655.2 5253592 5254848 R uncharacterized member of the APC superfamily of amino acid transporters; unknown function; hypothetical protein complement(5253592..5254848) Escherichia coli O157:H7 str. EDL933 959982 NP_290775.1 CDS groES NC_002655.2 5255124 5255417 D 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 5255124..5255417 Escherichia coli O157:H7 str. EDL933 959981 NP_290776.1 CDS groEL NC_002655.2 5255461 5257107 D 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; molecular chaperone GroEL 5255461..5257107 Escherichia coli O157:H7 str. EDL933 959980 NP_290777.1 CDS yjeI NC_002655.2 5257212 5257598 D hypothetical protein 5257212..5257598 Escherichia coli O157:H7 str. EDL933 959979 NP_290778.1 CDS yjeJ NC_002655.2 5257791 5258660 R hypothetical protein complement(5257791..5258660) Escherichia coli O157:H7 str. EDL933 959978 NP_290779.1 CDS yjeK NC_002655.2 5258895 5259923 R hypothetical protein complement(5258895..5259923) Escherichia coli O157:H7 str. EDL933 959977 NP_290780.1 CDS efp NC_002655.2 5259965 5260531 D Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 5259965..5260531 Escherichia coli O157:H7 str. EDL933 959976 NP_290781.1 CDS ecnA NC_002655.2 5260583 5260708 D acts as and antidote to the bacteriolytic entericidin B in the EcnAB toxin-antitoxin complex; entericidin A 5260583..5260708 Escherichia coli O157:H7 str. EDL933 959975 NP_290782.1 CDS ecnB NC_002655.2 5260819 5260965 D No significant matches; entericidin B 5260819..5260965 Escherichia coli O157:H7 str. EDL933 959974 NP_290783.1 CDS sugE NC_002655.2 5260991 5261458 D suppresses groEL, may be chaperone 5260991..5261458 Escherichia coli O157:H7 str. EDL933 959973 NP_290784.1 CDS blc NC_002655.2 5261455 5261988 R lipocalin; globomycin-sensitive outer membrane lipoprotein; outer membrane lipoprotein Blc complement(5261455..5261988) Escherichia coli O157:H7 str. EDL933 959972 NP_290785.1 CDS ampC NC_002655.2 5262076 5263209 R beta-lactamase complement(5262076..5263209) Escherichia coli O157:H7 str. EDL933 959971 NP_290786.1 CDS frdD NC_002655.2 5263272 5263631 R in conjunction with FrdC acts to anchor the catalytic components of the fumarate reductase to the cytoplasmic membrane; fumarate reductase subunit D complement(5263272..5263631) Escherichia coli O157:H7 str. EDL933 959970 NP_290787.1 CDS frdC NC_002655.2 5263642 5264037 R part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase subunit C complement(5263642..5264037) Escherichia coli O157:H7 str. EDL933 959969 NP_290788.1 CDS frdB NC_002655.2 5264048 5264782 R part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase iron-sulfur subunit complement(5264048..5264782) Escherichia coli O157:H7 str. EDL933 959968 NP_290789.1 CDS frdA NC_002655.2 5264775 5266583 R part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase flavoprotein subunit complement(5264775..5266583) Escherichia coli O157:H7 str. EDL933 959967 NP_290790.2 CDS yjeA NC_002655.2 5266908 5267885 D lysine--tRNA ligase beta chain; poxA; class II aminoacyl tRNA synthetase; catalyzes a two-step reaction; first charging a lysine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; lysyl-tRNA synthetase 5266908..5267885 Escherichia coli O157:H7 str. EDL933 959966 NP_290791.1 CDS yjeM NC_002655.2 5268104 5269606 D transport 5268104..5269606 Escherichia coli O157:H7 str. EDL933 959965 NP_290792.1 CDS yjeP NC_002655.2 5269757 5273080 R hypothetical protein complement(5269757..5273080) Escherichia coli O157:H7 str. EDL933 959964 NP_290793.1 CDS psd NC_002655.2 5273102 5274070 R catalyzes the decarboxylation of phosphatidyl-L-serine to phosphatidylethanoleamine; phosphatidylserine decarboxylase complement(5273102..5274070) Escherichia coli O157:H7 str. EDL933 959963 NP_290794.2 CDS yjeQ NC_002655.2 5274167 5275219 R EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity; ribosome-associated GTPase complement(5274167..5275219) Escherichia coli O157:H7 str. EDL933 959962 NP_290795.2 CDS yjeR NC_002655.2 5275314 5275859 D 3'-5' exoribonuclease specific for small oligoribonuclotides; oligoribonuclease 5275314..5275859 Escherichia coli O157:H7 str. EDL933 959961 NP_290796.1 CDS yjeS NC_002655.2 5276638 5277777 R hypothetical protein complement(5276638..5277777) Escherichia coli O157:H7 str. EDL933 959957 NP_290797.1 CDS yjeF NC_002655.2 5277776 5279323 D hypothetical protein 5277776..5279323 Escherichia coli O157:H7 str. EDL933 959956 NP_290798.1 CDS yjeE NC_002655.2 5279295 5279756 D possibly involved in cell wall synthesis; ATPase 5279295..5279756 Escherichia coli O157:H7 str. EDL933 959955 NP_290799.1 CDS amiB NC_002655.2 5279775 5281112 D N-acetylmuramoyl-L-alanine amidase 5279775..5281112 Escherichia coli O157:H7 str. EDL933 959954 NP_290800.1 CDS mutL NC_002655.2 5281122 5282969 D This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex; DNA mismatch repair protein 5281122..5282969 Escherichia coli O157:H7 str. EDL933 959953 NP_290801.1 CDS miaA NC_002655.2 5282962 5283912 D IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 5282962..5283912 Escherichia coli O157:H7 str. EDL933 959952 NP_290802.1 CDS hfq NC_002655.2 5283998 5284306 D Stimulates the elongation of poly(A) tails; RNA-binding protein Hfq 5283998..5284306 Escherichia coli O157:H7 str. EDL933 959951 NP_290803.1 CDS hflX NC_002655.2 5284383 5285663 D involved in modulation of proteins HflK and HflC; part of the hflA locus (high frequency of lysogenization) which governs the lysis-lysogeny decision of bacteriophage lambda by controlling stability of the phage cII protein; GTPase HflX 5284383..5285663 Escherichia coli O157:H7 str. EDL933 959950 NP_290804.1 CDS hflK NC_002655.2 5285749 5287008 D with HflC inhibits proteolysis of lambda cII protein by FtsH; FtsH protease regulator HflK 5285749..5287008 Escherichia coli O157:H7 str. EDL933 959949 NP_290805.1 CDS hflC NC_002655.2 5287011 5288015 D with HflK inhibits proteolysis of lambda cII protein by FtsH; FtsH protease regulator HflC 5287011..5288015 Escherichia coli O157:H7 str. EDL933 959948 NP_290806.1 CDS yjeT NC_002655.2 5288097 5288294 D hypothetical protein 5288097..5288294 Escherichia coli O157:H7 str. EDL933 959947 NP_290807.1 CDS purA NC_002655.2 5288398 5289696 D catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 5288398..5289696 Escherichia coli O157:H7 str. EDL933 959946 NP_290808.1 CDS yjeB NC_002655.2 5289902 5290327 D negatively regulates the transcription of genes upregulated by nitrosative stress; transcriptional repressor NsrR 5289902..5290327 Escherichia coli O157:H7 str. EDL933 959945 NP_290809.2 CDS vacB NC_002655.2 5290366 5292807 D 3'-5'exoribonuclease that acts nonspecifically on poly(A), poly(U) and ribosomal RNAs; exoribonuclease R 5290366..5292807 Escherichia coli O157:H7 str. EDL933 959944 NP_290810.1 CDS yjfH NC_002655.2 5292988 5293719 D Specifically methylates the ribose of guanosine 2251 in 23S rRNA; 23S rRNA (guanosine-2'-O-)-methyltransferase 5292988..5293719 Escherichia coli O157:H7 str. EDL933 959943 NP_290811.1 CDS yjfI NC_002655.2 5293846 5294247 D hypothetical protein 5293846..5294247 Escherichia coli O157:H7 str. EDL933 959942 NP_290812.1 CDS yjfJ NC_002655.2 5294266 5294964 D alpha helical protein 5294266..5294964 Escherichia coli O157:H7 str. EDL933 959941 NP_290813.1 CDS yjfK NC_002655.2 5295015 5295674 D hypothetical protein 5295015..5295674 Escherichia coli O157:H7 str. EDL933 959940 NP_290814.1 CDS yjfL NC_002655.2 5295692 5296090 D hypothetical protein 5295692..5296090 Escherichia coli O157:H7 str. EDL933 959939 NP_290815.1 CDS yjfM NC_002655.2 5296100 5296738 D hypothetical protein 5296100..5296738 Escherichia coli O157:H7 str. EDL933 959938 NP_290816.1 CDS yjfC NC_002655.2 5296741 5297904 D synthetase/amidase 5296741..5297904 Escherichia coli O157:H7 str. EDL933 959937 NP_290817.1 CDS aidB NC_002655.2 5297973 5299613 D catalyzes the formation of 3-methylcrotonyl-CoA from isovaleryl-CoA; isovaleryl CoA dehydrogenase 5297973..5299613 Escherichia coli O157:H7 str. EDL933 959936 NP_290818.1 CDS yjfN NC_002655.2 5299730 5300032 R hypothetical protein complement(5299730..5300032) Escherichia coli O157:H7 str. EDL933 959935 NP_290819.2 CDS yjfO NC_002655.2 5300154 5300483 R in Escherichia coli, mutation of this gene affects biofilm maturation, stress response, and motility; biofilm stress and motility protein A complement(5300154..5300483) Escherichia coli O157:H7 str. EDL933 959934 NP_290820.1 CDS yjfP NC_002655.2 5300665 5301414 D YjfP; esterase activity towards palmitoyl-CoA and pNP-butyrate in vitro; unknown function and substrate in vivo; esterase 5300665..5301414 Escherichia coli O157:H7 str. EDL933 959933 NP_290821.1 CDS yjfQ NC_002655.2 5301411 5302166 R negative regulator of ulaG and ulaABCDEF; transcriptional repressor UlaR complement(5301411..5302166) Escherichia coli O157:H7 str. EDL933 959932 NP_290822.1 CDS yjfR NC_002655.2 5302274 5303344 R L-ascorbate 6-phosphate lactonase complement(5302274..5303344) Escherichia coli O157:H7 str. EDL933 959931 NP_290823.2 CDS ulaA NC_002655.2 5303693 5305090 D membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC 5303693..5305090 Escherichia coli O157:H7 str. EDL933 959930 NP_290824.1 CDS sgaB NC_002655.2 5305106 5305411 D involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system L-ascorbate-specific transporter subunit IIB 5305106..5305411 Escherichia coli O157:H7 str. EDL933 959929 NP_290825.1 CDS ptxA NC_002655.2 5305421 5305885 D involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system L-ascorbate-specific transporter subunit IIA 5305421..5305885 Escherichia coli O157:H7 str. EDL933 959928 NP_290826.1 CDS ulaD NC_002655.2 5305899 5306549 D catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization; 3-keto-L-gulonate-6-phosphate decarboxylase 5305899..5306549 Escherichia coli O157:H7 str. EDL933 959927 NP_290827.1 CDS sgaU NC_002655.2 5306559 5307413 D UlaE; catalyzes the epimerization of L-ribulose-5-phosphate into L-xylulose-5-phosphate; part of the anaerobic L-ascorbate degradation pathway; L-xylulose 5-phosphate 3-epimerase 5306559..5307413 Escherichia coli O157:H7 str. EDL933 959926 NP_290828.1 CDS sgaE NC_002655.2 5307413 5308099 D catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; L-ribulose-5-phosphate 4-epimerase 5307413..5308099 Escherichia coli O157:H7 str. EDL933 959925 NP_290829.1 CDS yjfY NC_002655.2 5308228 5308503 R hypothetical protein complement(5308228..5308503) Escherichia coli O157:H7 str. EDL933 959924 NP_290830.1 CDS rpsF NC_002655.2 5308830 5309225 D binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 5308830..5309225 Escherichia coli O157:H7 str. EDL933 959923 NP_290831.1 CDS priB NC_002655.2 5309232 5309546 D binds single-stranded DNA at the primosome assembly site; primosomal replication protein N 5309232..5309546 Escherichia coli O157:H7 str. EDL933 959922 NP_290832.1 CDS rpsR NC_002655.2 5309551 5309778 D binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 5309551..5309778 Escherichia coli O157:H7 str. EDL933 959921 NP_290833.1 CDS rplI NC_002655.2 5309820 5310269 D in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 5309820..5310269 Escherichia coli O157:H7 str. EDL933 959920 NP_290834.1 CDS yjfZ NC_002655.2 5310340 5311134 R hypothetical protein complement(5310340..5311134) Escherichia coli O157:H7 str. EDL933 959919 NP_290835.1 CDS Z5814 NC_002655.2 5311574 5311756 R No significant matches; hypothetical protein complement(5311574..5311756) Escherichia coli O157:H7 str. EDL933 959918 NP_290836.1 CDS Z5815 NC_002655.2 5311757 5312173 R transposase complement(5311757..5312173) Escherichia coli O157:H7 str. EDL933 959917 NP_290837.1 CDS Z5816 NC_002655.2 5312196 5313404 D virulence protein 5312196..5313404 Escherichia coli O157:H7 str. EDL933 959916 NP_290838.1 CDS ytfB NC_002655.2 5313539 5314213 R hypothetical protein complement(5313539..5314213) Escherichia coli O157:H7 str. EDL933 959915 NP_290839.2 CDS fklB NC_002655.2 5314395 5315015 D FKBP-type; rotamase; catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; peptidyl-prolyl cis-trans isomerase 5314395..5315015 Escherichia coli O157:H7 str. EDL933 959914 NP_290840.1 CDS cycA NC_002655.2 5315324 5316736 D involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine; D-alanine/D-serine/glycine permease 5315324..5316736 Escherichia coli O157:H7 str. EDL933 959913 NP_290841.1 CDS ytfE NC_002655.2 5316781 5317443 R Involved in anaerobic NO protection and iron metabolism; iron-sulfur cluster repair di-iron protein complement(5316781..5317443) Escherichia coli O157:H7 str. EDL933 959912 NP_290842.1 CDS ytfF NC_002655.2 5317551 5318525 R transmembrane subunit complement(5317551..5318525) Escherichia coli O157:H7 str. EDL933 959911 NP_290843.1 CDS ytfG NC_002655.2 5318624 5319484 R oxidoreductase complement(5318624..5319484) Escherichia coli O157:H7 str. EDL933 959910 NP_290844.1 CDS ytfH NC_002655.2 5319483 5319953 D hypothetical protein 5319483..5319953 Escherichia coli O157:H7 str. EDL933 959909 NP_290845.1 CDS cpdB NC_002655.2 5320071 5322014 R periplasmic enzyme; functions during ribonucleic acid degradation; 2',3'-cyclic nucleotides are first converted to 3'-nucleotide and then cleaved to yield a ribonucleotide and a phosphate; bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic protein complement(5320071..5322014) Escherichia coli O157:H7 str. EDL933 959908 NP_290846.1 CDS cysQ NC_002655.2 5322204 5322944 D catalyzes the formation of AMP from adenosine-3',5'-bisphosphate; adenosine-3'(2'),5'-bisphosphate nucleotidase 5322204..5322944 Escherichia coli O157:H7 str. EDL933 959907 NP_290847.1 CDS Z5826 NC_002655.2 5323156 5324094 D hypothetical protein 5323156..5324094 Escherichia coli O157:H7 str. EDL933 959906 NP_290848.1 CDS ytfJ NC_002655.2 5324157 5324711 R hypothetical protein complement(5324157..5324711) Escherichia coli O157:H7 str. EDL933 959905 NP_290849.1 CDS ytfK NC_002655.2 5324997 5325242 D hypothetical protein 5324997..5325242 Escherichia coli O157:H7 str. EDL933 959904 NP_290850.1 CDS ytfL NC_002655.2 5325338 5326681 R transporter complement(5325338..5326681) Escherichia coli O157:H7 str. EDL933 959903 NP_290851.1 CDS msrA NC_002655.2 5327004 5327642 R this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress; methionine sulfoxide reductase A complement(5327004..5327642) Escherichia coli O157:H7 str. EDL933 959902 NP_290852.1 CDS ytfM NC_002655.2 5327848 5329581 D hypothetical protein 5327848..5329581 Escherichia coli O157:H7 str. EDL933 959881 NP_290853.1 CDS ytfN NC_002655.2 5329578 5333357 D hypothetical protein 5329578..5333357 Escherichia coli O157:H7 str. EDL933 959868 NP_290854.1 CDS ytfP NC_002655.2 5333360 5333701 D hypothetical protein 5333360..5333701 Escherichia coli O157:H7 str. EDL933 959842 NP_290855.1 CDS yjfA NC_002655.2 5333442 5333711 R hypothetical protein complement(5333442..5333711) Escherichia coli O157:H7 str. EDL933 959819 NP_290856.1 CDS chpS NC_002655.2 5333907 5334164 D part of the toxin-antitoxin ChpB-ChpS system; antitoxin ChpS 5333907..5334164 Escherichia coli O157:H7 str. EDL933 959818 NP_290857.1 CDS chpB NC_002655.2 5334158 5334508 D toxin of the ChpB-ChpS toxin-antitoxin system; toxin ChpB 5334158..5334508 Escherichia coli O157:H7 str. EDL933 959817 NP_290858.1 CDS ppa NC_002655.2 5334588 5335118 R catalyzes the hydrolysis of pyrophosphate to phosphate; inorganic pyrophosphatase complement(5334588..5335118) Escherichia coli O157:H7 str. EDL933 959816 NP_290859.1 CDS ytfQ NC_002655.2 5335428 5336384 D LACI-type transcriptional regulator 5335428..5336384 Escherichia coli O157:H7 str. EDL933 959815 NP_290860.1 CDS Z5839 NC_002655.2 5336524 5338026 D ABC transporter ATP-binding protein 5336524..5338026 Escherichia coli O157:H7 str. EDL933 959814 NP_290861.1 CDS ytfT NC_002655.2 5338037 5339062 D transport system permease 5338037..5339062 Escherichia coli O157:H7 str. EDL933 959813 NP_290862.1 CDS yjfF NC_002655.2 5339073 5340044 D membrane component of a sugar ABC transporter system; ABC transporter permease 5339073..5340044 Escherichia coli O157:H7 str. EDL933 959811 NP_290863.1 CDS fbp NC_002655.2 5340077 5341075 R catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate; fructose-1,6-bisphosphatase complement(5340077..5341075) Escherichia coli O157:H7 str. EDL933 959809 NP_290864.1 CDS yjfG NC_002655.2 5341251 5342624 D UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase 5341251..5342624 Escherichia coli O157:H7 str. EDL933 959808 NP_290865.1 CDS yjgA NC_002655.2 5342780 5343331 R hypothetical protein complement(5342780..5343331) Escherichia coli O157:H7 str. EDL933 959807 NP_290866.1 CDS pmbA NC_002655.2 5343425 5344777 D protease involved in proteolytic processing of the antibiotic Microcin B17 and in sensitivity to the DNA gyrase inhibitor LetD; peptidase PmbA 5343425..5344777 Escherichia coli O157:H7 str. EDL933 959805 NP_290867.1 CDS cybC NC_002655.2 5345045 5345347 D cytochrome b562 5345045..5345347 Escherichia coli O157:H7 str. EDL933 959804 NP_290868.1 CDS nrdG NC_002655.2 5345392 5345856 R activates anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions; anaerobic ribonucleotide reductase-activating protein complement(5345392..5345856) Escherichia coli O157:H7 str. EDL933 959803 NP_290869.1 CDS nrdD NC_002655.2 5346046 5348184 R Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates; anaerobic ribonucleoside triphosphate reductase complement(5346046..5348184) Escherichia coli O157:H7 str. EDL933 959802 NP_290870.1 CDS treC NC_002655.2 5348578 5350233 R trehalose-6-phosphate hydrolase complement(5348578..5350233) Escherichia coli O157:H7 str. EDL933 959801 NP_290871.1 CDS treB NC_002655.2 5350283 5351704 R phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system trehalose(maltose)-specific transporter subunit IIBC complement(5350283..5351704) Escherichia coli O157:H7 str. EDL933 959800 NP_290872.1 CDS treR NC_002655.2 5351823 5352770 R regulates genes involved in trehalose metabolism; binds the intermediate trehalose-6-phosphate; binds a dimer; regulates treBC operon; trehalose repressor complement(5351823..5352770) Escherichia coli O157:H7 str. EDL933 959799 NP_290873.1 CDS Z5852 NC_002655.2 5352819 5353007 D No significant matches; hypothetical protein 5352819..5353007 Escherichia coli O157:H7 str. EDL933 959798 NP_290874.1 CDS mgtA NC_002655.2 5353148 5355844 D P-type ATPase involved in magnesium influx; magnesium-transporting ATPase MgtA 5353148..5355844 Escherichia coli O157:H7 str. EDL933 959797 NP_290875.1 CDS yjgF NC_002655.2 5356050 5356475 R hypothetical protein complement(5356050..5356475) Escherichia coli O157:H7 str. EDL933 959796 NP_290876.1 CDS pyrI NC_002655.2 5356509 5356970 R involved in the allosteric regulation of aspartate carbamoyltransferase; aspartate carbamoyltransferase complement(5356509..5356970) Escherichia coli O157:H7 str. EDL933 959795 NP_290877.1 CDS pyrB NC_002655.2 5356983 5357918 R catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase complement(5356983..5357918) Escherichia coli O157:H7 str. EDL933 959794 NP_290878.1 CDS pyrL NC_002655.2 5357922 5358056 R pyrBI operon leader peptide complement(5357922..5358056) Escherichia coli O157:H7 str. EDL933 959793 NP_290879.1 CDS yjgG_1 NC_002655.2 5358036 5358158 D hypothetical protein 5358036..5358158 Escherichia coli O157:H7 str. EDL933 959792 NP_290880.1 CDS yjgG_2 NC_002655.2 5358186 5358368 D hypothetical protein 5358186..5358368 Escherichia coli O157:H7 str. EDL933 959791 NP_290881.1 CDS yjgH NC_002655.2 5358337 5358732 R hypothetical protein complement(5358337..5358732) Escherichia coli O157:H7 str. EDL933 959789 NP_290882.1 CDS yjgI NC_002655.2 5358863 5359576 R oxidoreductase complement(5358863..5359576) Escherichia coli O157:H7 str. EDL933 959788 NP_290883.1 CDS Z5863 NC_002655.2 5359750 5359914 D hypothetical protein 5359750..5359914 Escherichia coli O157:H7 str. EDL933 959787 NP_290884.1 CDS yjgJ NC_002655.2 5359986 5360240 D hypothetical protein 5359986..5360240 Escherichia coli O157:H7 str. EDL933 959786 NP_290885.1 CDS yjgK NC_002655.2 5360376 5360837 D hypothetical protein 5360376..5360837 Escherichia coli O157:H7 str. EDL933 959785 NP_290886.1 CDS yjgL NC_002655.2 5360960 5362750 D hypothetical protein 5360960..5362750 Escherichia coli O157:H7 str. EDL933 959784 NP_290887.1 CDS argI NC_002655.2 5362807 5363811 R catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation; E. coli K12 has two genes, argF and argI, capable of producing functional ornithine carbamoyltransferase. When both are active in the same cell, the two gene products form a family of four hybrid trimeric isoenzymes designated, FFF, FFI, FII, and III.; ornithine carbamoyltransferase subunit I complement(5362807..5363811) Escherichia coli O157:H7 str. EDL933 959783 NP_290888.1 CDS yjgD NC_002655.2 5363973 5364389 D hypothetical protein 5363973..5364389 Escherichia coli O157:H7 str. EDL933 959782 NP_290889.1 CDS Z5868 NC_002655.2 5364435 5364728 R hypothetical protein complement(5364435..5364728) Escherichia coli O157:H7 str. EDL933 959781 NP_290890.1 CDS yjgN NC_002655.2 5365104 5366327 D hypothetical protein 5365104..5366327 Escherichia coli O157:H7 str. EDL933 959780 NP_290891.1 CDS valS NC_002655.2 5366382 5369237 R valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase complement(5366382..5369237) Escherichia coli O157:H7 str. EDL933 959779 NP_290892.1 CDS holC NC_002655.2 5369237 5369680 R binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; DNA polymerase III subunit chi complement(5369237..5369680) Escherichia coli O157:H7 str. EDL933 959778 NP_290893.1 CDS pepA NC_002655.2 5370034 5371545 R catalyzes the removal of N-terminal amino acids preferably leucine from various peptides; leucyl aminopeptidase complement(5370034..5371545) Escherichia coli O157:H7 str. EDL933 959777 NP_290894.1 CDS yjgP NC_002655.2 5371812 5372912 D hypothetical protein 5371812..5372912 Escherichia coli O157:H7 str. EDL933 959776 NP_290895.1 CDS yjgQ NC_002655.2 5372909 5373994 D hypothetical protein 5372909..5373994 Escherichia coli O157:H7 str. EDL933 959775 NP_290896.1 CDS yjgR NC_002655.2 5374155 5375657 R hypothetical protein complement(5374155..5375657) Escherichia coli O157:H7 str. EDL933 959774 NP_290897.1 CDS yjgB NC_002655.2 5375787 5376848 R oxidoreductase complement(5375787..5376848) Escherichia coli O157:H7 str. EDL933 959773 NP_290898.1 CDS Z5878 NC_002655.2 5377177 5379126 D No significant matches; integrase 5377177..5379126 Escherichia coli O157:H7 str. EDL933 959771 NP_290899.1 CDS Z5879 NC_002655.2 5379326 5379652 D hypothetical protein 5379326..5379652 Escherichia coli O157:H7 str. EDL933 959770 NP_290900.1 CDS Z5880 NC_002655.2 5379892 5380539 D transposase 5379892..5380539 Escherichia coli O157:H7 str. EDL933 959769 NP_290901.1 CDS Z5881 NC_002655.2 5380722 5381099 R No significant matches; hypothetical protein complement(5380722..5381099) Escherichia coli O157:H7 str. EDL933 959768 NP_290902.1 CDS Z5882 NC_002655.2 5381221 5381487 R No significant matches; hypothetical protein complement(5381221..5381487) Escherichia coli O157:H7 str. EDL933 959767 NP_290904.1 CDS Z5884 NC_002655.2 5382557 5383024 R hypothetical protein complement(5382557..5383024) Escherichia coli O157:H7 str. EDL933 959765 NP_290905.1 CDS Z5885 NC_002655.2 5383211 5383786 D resolvase 5383211..5383786 Escherichia coli O157:H7 str. EDL933 959764 NP_290906.1 CDS Z5886 NC_002655.2 5383985 5385301 R No significant matches; hypothetical protein complement(5383985..5385301) Escherichia coli O157:H7 str. EDL933 959763 NP_290907.1 CDS Z5887 NC_002655.2 5385453 5386226 R No significant matches; hypothetical protein complement(5385453..5386226) Escherichia coli O157:H7 str. EDL933 959762 NP_290908.1 CDS Z5888 NC_002655.2 5386343 5386807 D hypothetical protein 5386343..5386807 Escherichia coli O157:H7 str. EDL933 959761 NP_290909.1 CDS Z5889 NC_002655.2 5386840 5386941 D No significant matches; hypothetical protein 5386840..5386941 Escherichia coli O157:H7 str. EDL933 959760 NP_290910.1 CDS Z5890 NC_002655.2 5387445 5388350 D integrase 5387445..5388350 Escherichia coli O157:H7 str. EDL933 959759 NP_290911.1 CDS Z5891 NC_002655.2 5388464 5388577 D No significant matches; hypothetical protein 5388464..5388577 Escherichia coli O157:H7 str. EDL933 959758 NP_290912.1 CDS Z5892 NC_002655.2 5388810 5389694 R hypothetical protein complement(5388810..5389694) Escherichia coli O157:H7 str. EDL933 959757 NP_290913.1 CDS Z5893 NC_002655.2 5389648 5389971 R hypothetical protein complement(5389648..5389971) Escherichia coli O157:H7 str. EDL933 959756 NP_290914.1 CDS Z5894 NC_002655.2 5390202 5391305 R No significant matches; hypothetical protein complement(5390202..5391305) Escherichia coli O157:H7 str. EDL933 959755 NP_290915.1 CDS Z5895 NC_002655.2 5391309 5392016 R No significant matches; hypothetical protein complement(5391309..5392016) Escherichia coli O157:H7 str. EDL933 959754 NP_290916.1 CDS Z5896 NC_002655.2 5392023 5393675 R hypothetical protein complement(5392023..5393675) Escherichia coli O157:H7 str. EDL933 959753 NP_290917.1 CDS Z5897 NC_002655.2 5393893 5397246 D hypothetical protein 5393893..5397246 Escherichia coli O157:H7 str. EDL933 959752 NP_290918.1 CDS Z5898 NC_002655.2 5397246 5403560 D hypothetical protein 5397246..5403560 Escherichia coli O157:H7 str. EDL933 959751 NP_290919.1 CDS Z5899 NC_002655.2 5403784 5406642 D ATP-dependent helicase 5403784..5406642 Escherichia coli O157:H7 str. EDL933 959750 NP_290920.1 CDS Z5900 NC_002655.2 5406645 5411579 D hypothetical protein 5406645..5411579 Escherichia coli O157:H7 str. EDL933 959749 NP_290921.1 CDS Z5901 NC_002655.2 5411579 5417920 D helicase 5411579..5417920 Escherichia coli O157:H7 str. EDL933 959748 NP_290922.1 CDS Z5902 NC_002655.2 5417917 5420031 D helicase 5417917..5420031 Escherichia coli O157:H7 str. EDL933 959747 NP_290924.1 CDS Z5904 NC_002655.2 5420984 5421229 R hypothetical protein complement(5420984..5421229) Escherichia coli O157:H7 str. EDL933 959745 NP_290925.1 CDS yjhS NC_002655.2 5421525 5422505 R hypothetical protein complement(5421525..5422505) Escherichia coli O157:H7 str. EDL933 959744 NP_290926.1 CDS yjhT NC_002655.2 5422570 5423784 R N-acetylneuraminic acid mutarotase complement(5422570..5423784) Escherichia coli O157:H7 str. EDL933 959743 NP_290927.1 CDS yjhA NC_002655.2 5423696 5424421 R hypothetical protein complement(5423696..5424421) Escherichia coli O157:H7 str. EDL933 959742 NP_290928.1 CDS fimB NC_002655.2 5425868 5426470 D inversion of on/off regulator of fimA; tyrosine recombinase 5425868..5426470 Escherichia coli O157:H7 str. EDL933 959741 NP_290929.1 CDS fimE NC_002655.2 5426948 5427544 D inversion of on/off regulator of fimA; tyrosine recombinase 5426948..5427544 Escherichia coli O157:H7 str. EDL933 959740 NP_290930.1 CDS fimA NC_002655.2 5428009 5428557 D major type 1 subunit fimbrin (pilin) 5428009..5428557 Escherichia coli O157:H7 str. EDL933 959739 NP_290931.1 CDS fimI NC_002655.2 5428514 5429161 D fimbrial protein 5428514..5429161 Escherichia coli O157:H7 str. EDL933 959738 NP_290932.1 CDS fimC NC_002655.2 5429198 5429923 D periplasmic chaperone, required for type 1 fimbriae 5429198..5429923 Escherichia coli O157:H7 str. EDL933 959737 NP_290933.1 CDS fimD NC_002655.2 5429990 5432626 D outer membrane protein; export and assembly of type 1 fimbriae, interrupted 5429990..5432626 Escherichia coli O157:H7 str. EDL933 959736 NP_290934.1 CDS fimF NC_002655.2 5432636 5433166 D fimbrial morphology protein 5432636..5433166 Escherichia coli O157:H7 str. EDL933 959735 NP_290935.1 CDS fimG NC_002655.2 5433179 5433682 D fimbrial morphology protein 5433179..5433682 Escherichia coli O157:H7 str. EDL933 959734 NP_290936.1 CDS fimH NC_002655.2 5433702 5434604 D minor fimbrial subunit, D-mannose specific adhesin 5433702..5434604 Escherichia coli O157:H7 str. EDL933 959733 NP_290937.1 CDS gntP NC_002655.2 5434778 5436121 R fructuronate transporter complement(5434778..5436121) Escherichia coli O157:H7 str. EDL933 959732 NP_290938.1 CDS uxuA NC_002655.2 5436461 5437645 D catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate from mannonate; mannonate dehydratase 5436461..5437645 Escherichia coli O157:H7 str. EDL933 959731 NP_290939.1 CDS uxuB NC_002655.2 5437727 5439187 D mannonate oxidoreductase 5437727..5439187 Escherichia coli O157:H7 str. EDL933 959730 NP_290940.1 CDS uxuR NC_002655.2 5439402 5440175 D regulates the expression of uxuBA; DNA-binding transcriptional repressor UxuR 5439402..5440175 Escherichia coli O157:H7 str. EDL933 959729 NP_290941.1 CDS yjiC NC_002655.2 5440316 5441146 R hypothetical protein complement(5440316..5441146) Escherichia coli O157:H7 str. EDL933 959728 NP_290942.1 CDS Z5924 NC_002655.2 5441480 5441623 D No significant matches; hypothetical protein 5441480..5441623 Escherichia coli O157:H7 str. EDL933 959727 NP_290943.1 CDS iraD NC_002655.2 5441810 5442211 D inhibitor of RssB activity in response to DNA damage; blocks degradation of stationary phase sigma factor RpoS; DNA replication/recombination/repair protein 5441810..5442211 Escherichia coli O157:H7 str. EDL933 959726 NP_290944.1 CDS yjiE NC_002655.2 5442204 5442932 R DNA-binding transcriptional regulator complement(5442204..5442932) Escherichia coli O157:H7 str. EDL933 959725 NP_290945.1 CDS iadA NC_002655.2 5443180 5444352 R isoaspartyl dipeptidase complement(5443180..5444352) Escherichia coli O157:H7 str. EDL933 959724 NP_290946.1 CDS yjiG NC_002655.2 5444365 5444826 R hypothetical protein complement(5444365..5444826) Escherichia coli O157:H7 str. EDL933 959723 NP_290947.1 CDS yjiH NC_002655.2 5444823 5445518 R hypothetical protein complement(5444823..5445518) Escherichia coli O157:H7 str. EDL933 959722 NP_290948.1 CDS Z5930 NC_002655.2 5445654 5446100 D hypothetical protein 5445654..5446100 Escherichia coli O157:H7 str. EDL933 959721 NP_290949.1 CDS Z5932 NC_002655.2 5446463 5451565 R invasin complement(5446463..5451565) Escherichia coli O157:H7 str. EDL933 959720 NP_290950.1 CDS yjiJ NC_002655.2 5451915 5453093 R transporter complement(5451915..5453093) Escherichia coli O157:H7 str. EDL933 959719 NP_290951.1 CDS yjiK NC_002655.2 5453161 5454150 R hypothetical protein complement(5453161..5454150) Escherichia coli O157:H7 str. EDL933 959718 NP_290952.1 CDS Z5935 NC_002655.2 5454269 5456464 R hypothetical protein complement(5454269..5456464) Escherichia coli O157:H7 str. EDL933 959717 NP_290953.1 CDS yjiL NC_002655.2 5457039 5457806 R hypothetical protein complement(5457039..5457806) Escherichia coli O157:H7 str. EDL933 959716 NP_290954.1 CDS yjiM NC_002655.2 5457816 5458988 R hypothetical protein complement(5457816..5458988) Escherichia coli O157:H7 str. EDL933 959714 NP_290955.1 CDS yjiN NC_002655.2 5459084 5460355 R hypothetical protein complement(5459084..5460355) Escherichia coli O157:H7 str. EDL933 959713 NP_290956.1 CDS yjiO NC_002655.2 5460396 5461628 R transporter complement(5460396..5461628) Escherichia coli O157:H7 str. EDL933 959712 NP_290957.1 CDS Z5940 NC_002655.2 5462095 5462877 D hypothetical protein 5462095..5462877 Escherichia coli O157:H7 str. EDL933 959711 NP_290958.1 CDS yjiR NC_002655.2 5463295 5464707 R regulator complement(5463295..5464707) Escherichia coli O157:H7 str. EDL933 959710 NP_290959.1 CDS yjiS NC_002655.2 5464884 5465048 D hypothetical protein 5464884..5465048 Escherichia coli O157:H7 str. EDL933 959709 NP_290960.1 CDS Z5943m NC_002655.2 5465145 5467237 D hypothetical protein join(5465145..5465948,5465948..5467237) Escherichia coli O157:H7 str. EDL933 959639 NP_290961.1 CDS Z5945 NC_002655.2 5467284 5467625 R involved in the degradation of RNA; may be involved in the recycling of RNA during the SOS response; endoribonuclease SymE complement(5467284..5467625) Escherichia coli O157:H7 str. EDL933 959708 NP_290962.1 CDS Z5946 NC_002655.2 5467846 5469600 R restriction modification enzyme S subunit complement(5467846..5469600) Escherichia coli O157:H7 str. EDL933 959707 NP_290963.1 CDS Z5947 NC_002655.2 5469600 5471081 R restriction modification enzyme subunit M complement(5469600..5471081) Escherichia coli O157:H7 str. EDL933 959706 NP_290964.1 CDS Z5948 NC_002655.2 5471136 5473568 R restriction modification enzyme subunit R complement(5471136..5473568) Escherichia coli O157:H7 str. EDL933 959705 NP_290965.1 CDS Z5949 NC_002655.2 5473846 5474130 D hypothetical protein 5473846..5474130 Escherichia coli O157:H7 str. EDL933 959704 NP_290966.1 CDS Z5950 NC_002655.2 5474139 5475497 D hypothetical protein 5474139..5475497 Escherichia coli O157:H7 str. EDL933 959703 NP_290967.1 CDS Z5951 NC_002655.2 5475566 5476420 R GTP-binding protein YjiA complement(5475566..5476420) Escherichia coli O157:H7 str. EDL933 959702 NP_290968.1 CDS yjiX NC_002655.2 5476533 5476736 R hypothetical protein complement(5476533..5476736) Escherichia coli O157:H7 str. EDL933 959701 NP_290969.1 CDS yjiY NC_002655.2 5476786 5478951 R carbon starvation protein complement(5476786..5478951) Escherichia coli O157:H7 str. EDL933 959700 NP_290970.1 CDS Z5954 NC_002655.2 5479229 5479771 R No significant matches; hypothetical protein complement(5479229..5479771) Escherichia coli O157:H7 str. EDL933 959699 NP_290971.1 CDS tsr NC_002655.2 5480000 5481664 D methyl-accepting chemotaxis protein I, serine sensor receptor 5480000..5481664 Escherichia coli O157:H7 str. EDL933 959698 NP_290972.1 CDS yjiZ NC_002655.2 5481713 5483074 R transport protein, cryptic, orf, joins former yjiZ and yjjL complement(5481713..5483074) Escherichia coli O157:H7 str. EDL933 959697 NP_290973.1 CDS yjjM NC_002655.2 5483290 5484096 R hypothetical protein complement(5483290..5484096) Escherichia coli O157:H7 str. EDL933 959696 NP_290974.1 CDS yjjN NC_002655.2 5484328 5485365 D oxidoreductase 5484328..5485365 Escherichia coli O157:H7 str. EDL933 959695 NP_290975.2 CDS mdoB NC_002655.2 5485502 5487793 R catalyzes the transfer of phosphoglycerol to the glucan backbone; phosphoglycerol transferase I complement(5485502..5487793) Escherichia coli O157:H7 str. EDL933 959694 NP_290976.1 CDS yjjA NC_002655.2 5488047 5488544 R hypothetical protein complement(5488047..5488544) Escherichia coli O157:H7 str. EDL933 959693 NP_290977.1 CDS dnaC NC_002655.2 5488590 5489327 R acts to load the DnaB helicase onto the initiation site during DNA replication; DNA replication protein DnaC complement(5488590..5489327) Escherichia coli O157:H7 str. EDL933 959692 NP_290978.1 CDS dnaT NC_002655.2 5489330 5489869 R This protein is required for primosome-dependent normal DNA replication; it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with dnaB protein and other prepriming proteins dnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N'; primosomal protein DnaI complement(5489330..5489869) Escherichia coli O157:H7 str. EDL933 959691 NP_290979.2 CDS yjjB NC_002655.2 5489976 5490449 R hypothetical protein complement(5489976..5490449) Escherichia coli O157:H7 str. EDL933 959690 NP_290980.1 CDS yjjP NC_002655.2 5490440 5491273 R structural protein complement(5490440..5491273) Escherichia coli O157:H7 str. EDL933 959689 NP_290981.1 CDS yjjQ NC_002655.2 5491831 5492556 D regulator 5491831..5492556 Escherichia coli O157:H7 str. EDL933 959688 NP_290982.2 CDS bglJ NC_002655.2 5492568 5493191 D regulator for the transport and utilization of the aromatic beta-glucosides arbutin and silicin; DNA-binding transcriptional activator BglJ 5492568..5493191 Escherichia coli O157:H7 str. EDL933 959687 NP_290983.1 CDS fhuF NC_002655.2 5493229 5494017 R ferric hydroximate transport ferric iron reductase complement(5493229..5494017) Escherichia coli O157:H7 str. EDL933 959686 NP_290984.1 CDS rsmC NC_002655.2 5494709 5495740 R 16S rRNA M2G1207 methyltransferase; one of many enzymes that modify bases of the ribosomal RNA; this enzyme methylates the G at position 1207 of the small ribosomal subunit; 16S ribosomal RNA m2G1207 methyltransferase complement(5494709..5495740) Escherichia coli O157:H7 str. EDL933 959684 NP_290985.1 CDS holD NC_002655.2 5495843 5496256 D with the chi subunit binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; DNA polymerase III subunit psi 5495843..5496256 Escherichia coli O157:H7 str. EDL933 959683 NP_290986.1 CDS rimI NC_002655.2 5496225 5496671 D alanine acetyltransferase that specifically acetylates ribosomal protein S18; ribosomal-protein-alanine N-acetyltransferase 5496225..5496671 Escherichia coli O157:H7 str. EDL933 959682 NP_290987.1 CDS yjjG NC_002655.2 5496686 5497363 D manganese-dependent 5'-nucleotidase; specific for 5'-UMP, 5'-dUMP, and 5'-dTMP; member of haloacid dehalogenase (HAD)-like hydrolase superfamily; nucleotidase 5496686..5497363 Escherichia coli O157:H7 str. EDL933 959681 NP_290988.1 CDS prfC NC_002655.2 5497454 5499043 D stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein; peptide chain release factor 3 5497454..5499043 Escherichia coli O157:H7 str. EDL933 959680 NP_290989.1 CDS osmY NC_002655.2 5499436 5500041 D hypothetical protein 5499436..5500041 Escherichia coli O157:H7 str. EDL933 959679 NP_290990.1 CDS Z5978 NC_002655.2 5500150 5500329 D No significant matches; hypothetical protein 5500150..5500329 Escherichia coli O157:H7 str. EDL933 959678 NP_290991.1 CDS yjjU NC_002655.2 5500451 5501524 D hypothetical protein 5500451..5501524 Escherichia coli O157:H7 str. EDL933 959677 NP_290992.1 CDS yjjV NC_002655.2 5501665 5502348 D hypothetical protein 5501665..5502348 Escherichia coli O157:H7 str. EDL933 959676 NP_290993.1 CDS yjjW NC_002655.2 5502516 5503379 R activating enzyme complement(5502516..5503379) Escherichia coli O157:H7 str. EDL933 959675 NP_290994.1 CDS yjjI NC_002655.2 5503351 5504901 R hypothetical protein complement(5503351..5504901) Escherichia coli O157:H7 str. EDL933 959674 NP_290995.1 CDS deoC NC_002655.2 5505159 5505938 D catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase 5505159..5505938 Escherichia coli O157:H7 str. EDL933 959673 NP_290996.1 CDS deoA NC_002655.2 5506065 5507387 D Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate; thymidine phosphorylase 5506065..5507387 Escherichia coli O157:H7 str. EDL933 959672 NP_290997.1 CDS deoB NC_002655.2 5507439 5508662 D catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose; phosphopentomutase 5507439..5508662 Escherichia coli O157:H7 str. EDL933 959671 NP_290998.1 CDS deoD NC_002655.2 5508719 5509438 D catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate; purine nucleoside phosphorylase 5508719..5509438 Escherichia coli O157:H7 str. EDL933 959670 NP_290999.1 CDS Z5987 NC_002655.2 5509599 5509862 R No significant matches; hypothetical protein complement(5509599..5509862) Escherichia coli O157:H7 str. EDL933 959669 NP_291000.1 CDS Z5988 NC_002655.2 5509894 5511582 R in E. coli the lipoate ligase A catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl on the lipoate-dependent enzymes; creates an amide linkage that joins the free carboxyl group of lipoic acid to the epsilon-amino group of a specific lysine residue in lipoyl domain of apoproteins; hypothetical protein complement(5509894..5511582) Escherichia coli O157:H7 str. EDL933 959668 NP_291001.1 CDS serB NC_002655.2 5511688 5512656 D catalyzes the formation of serine from O-phosphoserine; phosphoserine phosphatase 5511688..5512656 Escherichia coli O157:H7 str. EDL933 959667 NP_291002.1 CDS sms NC_002655.2 5512705 5514087 D Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 5512705..5514087 Escherichia coli O157:H7 str. EDL933 959666 NP_291003.2 CDS nadR NC_002655.2 5514108 5515340 D catalyzes the formation of NAD(+) from nicotinamide ribonucleotide; nicotinamide-nucleotide adenylyltransferase 5514108..5515340 Escherichia coli O157:H7 str. EDL933 959665 NP_291004.1 CDS yjjK NC_002655.2 5515648 5517315 R ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence; ABC transporter ATP-binding protein complement(5515648..5517315) Escherichia coli O157:H7 str. EDL933 959664 NP_291005.2 CDS slt NC_002655.2 5517526 5519463 D catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine residues in peptidoglycan; lytic murein transglycosylase 5517526..5519463 Escherichia coli O157:H7 str. EDL933 959663 NP_291006.1 CDS trpR NC_002655.2 5519553 5519879 D When complexed with L-tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription; Trp operon repressor 5519553..5519879 Escherichia coli O157:H7 str. EDL933 959662 NP_291007.2 CDS yjjX NC_002655.2 5520026 5520538 R pyrophosphatase; has activity against dUTP and dITP; the crystal structure of the Vibrio protein showed similarity to Methanococcus janaschii Mj0226; in Vibrio cholerae this gene is part of the Mba operon that is involved in regulation and maintenance of biofilms; in Escherichia coli overexpression of this gene leads to resistance to an HMP analog; NTPase complement(5520026..5520538) Escherichia coli O157:H7 str. EDL933 959661 NP_291008.1 CDS gpmB NC_002655.2 5520590 5521237 D catalyzes reactions involving the transfer of phospho groups between the three carbon atoms of phosphoglycerate; phosphoglycerate mutase 5520590..5521237 Escherichia coli O157:H7 str. EDL933 959660 NP_291009.1 CDS rob NC_002655.2 5521234 5522103 R right origin-binding protein complement(5521234..5522103) Escherichia coli O157:H7 str. EDL933 959659 NP_291010.1 CDS creA NC_002655.2 5522314 5522787 D hypothetical protein 5522314..5522787 Escherichia coli O157:H7 str. EDL933 959658 NP_291011.1 CDS creB NC_002655.2 5522800 5523489 D response regulator in two-component regulatory system with CreC; CreB protein is phosphorylated by sensor protein phospho-CreC; involved in catabolic regulation; DNA-binding response regulator CreB 5522800..5523489 Escherichia coli O157:H7 str. EDL933 959657 NP_291012.1 CDS creC NC_002655.2 5523489 5524913 D part of a two-component regulatory system with CreB or PhoB; involved in catabolic regulation; sensory histidine kinase CreC 5523489..5524913 Escherichia coli O157:H7 str. EDL933 959656 NP_291013.1 CDS creD NC_002655.2 5524971 5526323 D hypothetical protein 5524971..5526323 Escherichia coli O157:H7 str. EDL933 959655 NP_291014.1 CDS arcA NC_002655.2 5526383 5527099 R two-component response regulator complement(5526383..5527099) Escherichia coli O157:H7 str. EDL933 959654 NP_291015.1 CDS yjjY NC_002655.2 5527195 5527335 D hypothetical protein 5527195..5527335 Escherichia coli O157:H7 str. EDL933 959653 NP_291016.1 CDS lasT NC_002655.2 5527735 5528421 D member of the SPOUT superfamily of methyltransferases; RNA methyltransferase 5527735..5528421 Escherichia coli O157:H7 str. EDL933 959652 YP_325561.1 CDS finO NC_007414.1 1 561 D conjugal transfer repressor; 97 pct identical amino acid sequence and equal length to FIO1_ECOLI SW: P22707; conjugal transfer fertility inhibition protein FinO 1..561 Escherichia coli O157:H7 str. EDL933 3683668 YP_325562.1 CDS L7002 NC_007414.1 698 949 D 54 pct identical (1 gap) to 23 residues of an approx. 269 aa protein EXOK_RHIME SW: P33693; hypothetical protein 698..949 Escherichia coli O157:H7 str. EDL933 3683669 YP_325563.1 CDS L7003 NC_007414.1 1151 1612 D 15.6 kDa protein in finO 3' region precursor; 98 pct identical and equal length to YFI3_ECOLI SW: Q99342; hypothetical protein 1151..1612 Escherichia coli O157:H7 str. EDL933 3683670 YP_325564.1 CDS L7004 NC_007414.1 1658 1867 D 55 pct identical (0 gaps) to 66 residues of an approx. 72 aa protein HHA_ECOLI SW: P23870; putative hemolysin expression-modulating protein 1658..1867 Escherichia coli O157:H7 str. EDL933 3683671 YP_325565.1 CDS L7005 NC_007414.1 1905 2243 D 98 pct identical (0 gaps) to 57 residues of an approx. 200 aa protein; plasmid R100 miniplasmid pSM1 ORF 4, TRSW: Q52340; hypothetical protein 1905..2243 Escherichia coli O157:H7 str. EDL933 3683672 YP_325566.1 CDS cpb2 NC_007414.1 2483 2737 D RepA2 protein; 98 pct identical amino acid sequence and equal length to CPB2_ECOLI SW: P03847; replication protein 2483..2737 Escherichia coli O157:H7 str. EDL933 3683697 YP_325567.1 CDS L7007 NC_007414.1 2973 3047 D RepA6; leader peptide RepL 2973..3047 Escherichia coli O157:H7 str. EDL933 3683698 YP_325568.1 CDS rep2 NC_007414.1 3040 3897 D RepA; replication protein 3040..3897 Escherichia coli O157:H7 str. EDL933 3683699 YP_325569.1 CDS L7009 NC_007414.1 4259 4453 D 95 pct identical to (0 gaps) 64 residues of a 128 aa protein REPA4 locus ECRSC1 accession V00351; replication protein 4259..4453 Escherichia coli O157:H7 str. EDL933 3683700 YP_325570.1 CDS L7010 NC_007414.1 4810 5094 D 28 pct identical to 67 residues of a 82 aa protein Y4KO_RHISN SW : P55533; hypothetical protein 4810..5094 Escherichia coli O157:H7 str. EDL933 3683701 YP_325571.1 CDS L7011 NC_007414.1 5094 5369 D 81 pct identical (1 gaps) to 42 residues of an approx. 42 aa protein ORF2 fragment TRSW Q47652; plasmid stability locus; hypothetical protein 5094..5369 Escherichia coli O157:H7 str. EDL933 3683702 YP_325572.1 CDS L7012 NC_007414.1 5440 5727 R 37 pct identical (2 gaps) to 43 residues of an approx. 675 aa protein COP1_ARATH SW: P43254; hypothetical protein complement(5440..5727) Escherichia coli O157:H7 str. EDL933 3683703 YP_325574.1 CDS L7014 NC_007414.1 6029 6763 R 98 pct identical to 188 residues of a 272 aa protein YIS2_SHISO SW: P16940; IS600; hypothetical protein complement(6029..6763) Escherichia coli O157:H7 str. EDL933 3683713 YP_325575.1 CDS L7015 NC_007414.1 6547 7056 R 96 pct identical (0 gaps) to 139 residues of an approx. 426 aa protein transposase of IS91 accession Q47315; transposase complement(6547..7056) Escherichia coli O157:H7 str. EDL933 3683714 YP_325576.1 CDS L7016 NC_007414.1 7041 7280 D 26 pct identical (1 gaps) to 26 residues of an approx. 1180 aa protein ITA1_RAT SW: P18614; hypothetical protein 7041..7280 Escherichia coli O157:H7 str. EDL933 3683715 YP_325577.1 CDS katP NC_007414.1 7373 9583 D 100 pct identical to katP ECEHECCTP accession Number X89017; EHEC-catalase/peroxidase 7373..9583 Escherichia coli O157:H7 str. EDL933 3683716 YP_325578.1 CDS L7018 NC_007414.1 9627 10016 D 100 pct identical (0 gaps) and equal length to an unidentified 129 aa protein, accession X97542; hypothetical protein 9627..10016 Escherichia coli O157:H7 str. EDL933 3683717 YP_325579.1 CDS L7019 NC_007414.1 10174 11061 D 96 pct identical to 295 residues of a 296 aa protein TRA6_SHISO SW: P16942, IS629 transposase; transposase 10174..11061 Escherichia coli O157:H7 str. EDL933 3683718 YP_325580.1 CDS espP NC_007414.1 11242 15144 D 100 pct identical and equal length to a a putative exoprotein-precursor ECDNAPLAS accession X97542; putative exoprotein-precursor 11242..15144 Escherichia coli O157:H7 str. EDL933 3683719 YP_325581.1 CDS L7021 NC_007414.1 15307 15414 R 42 pct identical (3 gaps) to 35 residues of an approx. 952 aa protein SEN3_YEAST SW: P32565; hypothetical protein complement(15307..15414) Escherichia coli O157:H7 str. EDL933 3683720 YP_325582.1 CDS insA NC_007414.1 15609 15881 R 85 pct identical and equal length to ISA2_SHIDY SW: P03829, IS element iso-IS1N; transposase complement(15609..15881) Escherichia coli O157:H7 str. EDL933 3683721 YP_325583.1 CDS L7023 NC_007414.1 16148 16297 R 85 pct identical (0 gaps) to 46 residues of an approx. 78 aa protein PERD_ECOLI SW:P43476, function unknown; hypothetical protein complement(16148..16297) Escherichia coli O157:H7 str. EDL933 3683722 YP_325584.1 CDS L7024 NC_007414.1 16587 16721 D 49 pct identical (0 gaps) to 43 residues of an approx. 200 aa FIMB_ECOLI SW: P04742; regulatory protein 16587..16721 Escherichia coli O157:H7 str. EDL933 3683723 YP_325585.1 CDS L7025 NC_007414.1 16882 17055 D 44 pct identical (0 gaps) to 23 residues of an approx. 136 aa protein YM33_MARPO SW: P38475; hypothetical protein 16882..17055 Escherichia coli O157:H7 str. EDL933 3683724 YP_325586.1 CDS L7026 NC_007414.1 17323 18144 D 70 pct identical (0 gaps) to 102 residues of an approx. 152 aa protein SHF2 SW: P72437; hypothetical protein 17323..18144 Escherichia coli O157:H7 str. EDL933 3683725 YP_325587.1 CDS L7027 NC_007414.1 18147 19250 D 32 pct identical (2 gaps) to 164 residues of an approx. 377 aa protein YPJH_BACSU SW: P42982; hypothetical protein 18147..19250 Escherichia coli O157:H7 str. EDL933 3683726 YP_325588.1 CDS L7028 NC_007414.1 19340 21061 D 83 pct identical (0 gaps) to 513 residues of an approx. 577 aa protein YIJP_ECOLI SW: P32678; hypothetical protein 19340..21061 Escherichia coli O157:H7 str. EDL933 3683727 YP_325589.1 CDS L7029 NC_007414.1 21102 22133 D Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase 21102..22133 Escherichia coli O157:H7 str. EDL933 3683728 YP_325590.1 CDS L7030 NC_007414.1 22421 22594 D 32 pct identical (0 gaps) to 57 residues of an approx. 364 aa protein PGLR_COCCA, SW: P26215; hypothetical protein 22421..22594 Escherichia coli O157:H7 str. EDL933 3683729 YP_325591.1 CDS L7031 NC_007414.1 23016 25712 D 43 pct identical (17 gaps) to 131 residues of an approx. 904 aa protein TAGA TRSW: Q56595; hypothetical protein 23016..25712 Escherichia coli O157:H7 str. EDL933 3683730 YP_325592.1 CDS etpC NC_007414.1 25799 26674 D 99 pct identical (0 gaps) and equal length to locus ECPO157 accession Y09824; type II secretion protein 25799..26674 Escherichia coli O157:H7 str. EDL933 3683731 YP_325593.1 CDS etpD NC_007414.1 26714 28642 D 100 pct identical to locus ECPO157 accession Y09824, alternate start for etpD chosen in Y09824; type II secretion protein 26714..28642 Escherichia coli O157:H7 str. EDL933 3683732 YP_325594.1 CDS etpE NC_007414.1 28642 30147 D 99 pct identical (0 gaps) and equal length to locus ECPO157 accession Y09824; type II secretion protein 28642..30147 Escherichia coli O157:H7 str. EDL933 3683733 YP_325595.1 CDS etpF NC_007414.1 30149 31372 D 100 pct identical (0 gaps)to locus ECPO157 accession Y09824; type II secretion protein 30149..31372 Escherichia coli O157:H7 str. EDL933 3683734 YP_325596.1 CDS etpG NC_007414.1 31403 31837 D 100 pct identical (0 gaps) to locus ECPO157 accession Y09824; type II secretion protein 31403..31837 Escherichia coli O157:H7 str. EDL933 3683735 YP_325597.1 CDS etpH NC_007414.1 31834 32388 D 100 pct identical (0 gaps) to locus ECPO157 accession Y09824; type II secretion protein 31834..32388 Escherichia coli O157:H7 str. EDL933 3683736 YP_325598.1 CDS etpI NC_007414.1 32385 32750 D 100 pct identical to locus ECPO157 accession Y09824, different start in Y09824; type II secretion protein 32385..32750 Escherichia coli O157:H7 str. EDL933 3683737 YP_325599.1 CDS etpJ NC_007414.1 32747 33346 D 100 pct identical (0 gaps) to locus ECPO157 accession Y09824; type II secretion protein 32747..33346 Escherichia coli O157:H7 str. EDL933 3683738 YP_325600.1 CDS etpK NC_007414.1 33343 34320 D 100 pct identical (0 gaps) to locus ECPO157 accession Y09824; type II secretion protein 33343..34320 Escherichia coli O157:H7 str. EDL933 3683739 YP_325601.1 CDS etpL NC_007414.1 34254 35531 D 100 pct identical (0 gaps) to locus ECPO157 accession Y09824, alternate start in Y09824; type II secretion protein 34254..35531 Escherichia coli O157:H7 str. EDL933 3683740 YP_325602.1 CDS etpM NC_007414.1 35518 36030 D 100 pct identical (0 gaps) to locus ECPO157 accession Y09824; type II secretion protein 35518..36030 Escherichia coli O157:H7 str. EDL933 3683741 YP_325603.1 CDS etpN NC_007414.1 36088 36921 D 100 pct identical (0 gaps) to locus ECPO157 accession Y09824, alternate start in Y09824; type II secretion protein 36088..36921 Escherichia coli O157:H7 str. EDL933 3683742 YP_325604.1 CDS etpO NC_007414.1 37013 37414 D 100 pct identical (0 gaps) to locus ECPO157 accession Y09824; type II secretion protein 37013..37414 Escherichia coli O157:H7 str. EDL933 3683743 YP_325605.1 CDS L7045 NC_007414.1 37557 37898 D 97 pct identical (1 gaps) to 112 residues of an approx. 112 aa protein YI91_SHIDY SW: P39213, IS911; hypothetical protein 37557..37898 Escherichia coli O157:H7 str. EDL933 3683744 YP_325606.1 CDS L7046 NC_007414.1 37943 38764 D IS911; ORFB; 91 pct identical (0 gaps) to 265 residues of an approx. 267 aa protein SDIS911, accession X17613; hypothetical protein 37943..38764 Escherichia coli O157:H7 str. EDL933 3683745 YP_325607.1 CDS EHEC-hlyC NC_007414.1 39305 39820 D 99 pct identical (0 gaps) to 168 residues of an 168 aa protein EHEC-hlyC TRSW: Q47460, alternate start in Q47460; hemolysin transport protein 39305..39820 Escherichia coli O157:H7 str. EDL933 3683746 YP_325608.1 CDS EHEC-hlyA NC_007414.1 39822 42818 D 99 pct identical (0 gaps) and equal length to a protein EHEC-hlyA TRSW: Q47461; hemolysin toxin protein 39822..42818 Escherichia coli O157:H7 str. EDL933 3683747 YP_325609.1 CDS EHEC-hlyB NC_007414.1 42868 44988 D 99 pct identical and equal length to EHEC-hlyB TRSW: Q47462; hemolysin transport protein 42868..44988 Escherichia coli O157:H7 str. EDL933 3683748 YP_325610.1 CDS EHEC-hlyD NC_007414.1 44992 46431 D 99 pct identical and equal length to EHEC-hlyD TRSW: Q47463; hemolysin transport protein 44992..46431 Escherichia coli O157:H7 str. EDL933 3683705 YP_325611.1 CDS L7051 NC_007414.1 46498 46692 D 49 pct identical (0 gaps) to 41 residues of an approx.164 aa protein PAPX_ECOLI SW: P42193; hypothetical protein 46498..46692 Escherichia coli O157:H7 str. EDL933 3683706 YP_325612.1 CDS L7052 NC_007414.1 46722 47006 D 52 pct identical (0 gaps) to 79 residues of an approx. 164 aa protein PAPX_ECOLI SW: P42193; hypothetical protein 46722..47006 Escherichia coli O157:H7 str. EDL933 3683707 YP_325613.1 CDS L7053 NC_007414.1 47175 47405 D 47 pct identical (1 gaps) to 32 residues of an approx. 1240 aa protein R31240_1 TRSW: O00114; putative serine-threonine protein kinase 47175..47405 Escherichia coli O157:H7 str. EDL933 3683708 YP_325614.1 CDS L7054 NC_007414.1 47910 48266 D 100 pct identical and equal length to a 118 aa protein 'ORF3' locus FPLREPFIB accession M26308; replication protein 47910..48266 Escherichia coli O157:H7 str. EDL933 3683709 YP_325615.1 CDS L7055 NC_007414.1 47955 48272 R 96 pct identical and equal length to a 105 aa protein 'ORF5' locus FPLREPFIB accession M26308; replication protein complement(47955..48272) Escherichia coli O157:H7 str. EDL933 3683710 YP_325616.2 CDS L7056 NC_007414.1 48551 49528 R 99 pct identical and equal length to a 317 aa protein 'ORF1' locus FPLREPFIB accession M26308; replication protein complement(48551..49528) Escherichia coli O157:H7 str. EDL933 3683711 YP_325617.1 CDS L7057 NC_007414.1 49266 49595 D 100 pct identical and equal length to a 109 aa protein 'ORF4' locus FPLREPFIB accession M26308; replication protein 49266..49595 Escherichia coli O157:H7 str. EDL933 3683712 YP_325618.1 CDS L7058 NC_007414.1 49936 50172 R 32 pct identical (3 gaps) to 51 residues of an approx. 360 aa protein RECA_BRUAB SW: Q04761; hypothetical protein complement(49936..50172) Escherichia coli O157:H7 str. EDL933 3683687 YP_325619.1 CDS L7059 NC_007414.1 50133 50753 R 23 pct identical (4 gaps) to 111 residues of an approx. 247 aa protein LANP_RAT SW: P49911; hypothetical protein complement(50133..50753) Escherichia coli O157:H7 str. EDL933 3683688 YP_325620.1 CDS L7060 NC_007414.1 50750 51433 R 31 pct identical (8 gaps) to 179 residues of an approx. 344 aa protein KFRA TRSW: P71173; hypothetical protein complement(50750..51433) Escherichia coli O157:H7 str. EDL933 3683689 YP_325621.1 CDS L7061 NC_007414.1 51489 51683 D 37 pct identical (0 gaps) to 30 residues of an approx. 680 aa protein PIRA7 accession U96688; hypothetical protein 51489..51683 Escherichia coli O157:H7 str. EDL933 3683690 YP_325622.1 CDS ccdA NC_007414.1 51892 52110 D 90 pct identical amino acid sequence and equal length to ECU51588 accession U51588; plasmid maintenance protein CcdA 51892..52110 Escherichia coli O157:H7 str. EDL933 3683691 YP_325623.1 CDS ccdB NC_007414.1 52112 52417 D controlled cell death protein; post-segregation toxin; toxin addiction system; plasmid maintenance protein CcdB 52112..52417 Escherichia coli O157:H7 str. EDL933 3683692 YP_325624.1 CDS redF NC_007414.1 52418 53224 D protein D; 98 pct identical amino acid sequence and equal length to REDF_ECOLI SW: P06615; resolvase 52418..53224 Escherichia coli O157:H7 str. EDL933 3683693 YP_325625.1 CDS tra6 NC_007414.1 53311 54201 R 97 pct identical amino acid sequence and equal length to TRA6_SHISO SW: P16942, IS629; transposase complement(53311..54201) Escherichia coli O157:H7 str. EDL933 3683694 YP_325626.1 CDS L7066 NC_007414.1 54198 54524 R 100 pct identical to YIS3_SHISO SW: P16941, an IS629 protein; hypothetical protein complement(54198..54524) Escherichia coli O157:H7 str. EDL933 3683695 YP_325627.1 CDS L7067 NC_007414.1 54669 54824 D 100 pct identical to a 51 aa protein of approx. 251 aa protein E1_ECOLI, TRSW: P03856; rep protein E1 54669..54824 Escherichia coli O157:H7 str. EDL933 3683696 YP_325628.1 CDS sopA NC_007414.1 55412 56578 D 100 pct identical amino acid sequence and equal length to SOPA_ECOLI SW: P08866; plasmid-partitioning protein SopA 55412..56578 Escherichia coli O157:H7 str. EDL933 3683673 YP_325629.1 CDS sopB NC_007414.1 56578 57549 D SopB; plasmid-partitioning protein 56578..57549 Escherichia coli O157:H7 str. EDL933 3683674 YP_325630.1 CDS L7070 NC_007414.1 57934 58206 D 100 pct identical to 25 residues of a 79 aa protein YPF8_ECOLI SW: P08868; hypothetical protein 57934..58206 Escherichia coli O157:H7 str. EDL933 3683675 YP_325631.1 CDS L7071 NC_007414.1 58290 58586 R 36 pct identical (4 gaps) to 47 residues of an approx. 616 aa protein VE1_HPV1A SW: P03111; hypothetical protein complement(58290..58586) Escherichia coli O157:H7 str. EDL933 3683676 YP_325632.1 CDS L7072 NC_007414.1 58849 60573 D 29 pct identical (21 gaps) to 521 residues of an approx. 608 aa protein RDPO_SCEOB SW: P19593; hypothetical protein 58849..60573 Escherichia coli O157:H7 str. EDL933 3683677 YP_325633.1 CDS L7073 NC_007414.1 60650 61552 D 25 pct identical (21 gaps) to 126 residues of an approx. 160 aa protein CR18_ORYSA SW: Q06397; hypothetical protein 60650..61552 Escherichia coli O157:H7 str. EDL933 3683678 YP_325634.1 CDS L7074 NC_007414.1 61938 62621 D 33 pct identical (14 gaps) to 204 residues of an approx. 232 aa TRSW: Q56638; putative methylase 61938..62621 Escherichia coli O157:H7 str. EDL933 3683679 YP_325635.1 CDS L7075 NC_007414.1 62737 63291 D 28 pct identical (3 gaps) to 101 residues of an approx. 184 aa protein X169_CRIGR SW: P41228; hypothetical protein 62737..63291 Escherichia coli O157:H7 str. EDL933 3683680 YP_325636.1 CDS L7076 NC_007414.1 63337 64113 D 31 pct identical (2 gaps) to 60 residues of an approx. 480 aa protein VL2_HPV29 SW: P50800; hypothetical protein 63337..64113 Escherichia coli O157:H7 str. EDL933 3683681 YP_325637.1 CDS L7077 NC_007414.1 64531 64956 D 36 pct identical (6 gaps) to 137 residues of an approx. 142 aa protein KLA1_ECOLI SW: P52602; hypothetical protein 64531..64956 Escherichia coli O157:H7 str. EDL933 3683682 YP_325638.1 CDS L7078 NC_007414.1 65003 65425 D 25 pct identical (4 gaps) to 109 residues of an approx. 1976 aa protein MYSA_CAEEL SW: P12844; hypothetical protein 65003..65425 Escherichia coli O157:H7 str. EDL933 3683683 YP_325639.1 CDS L7079 NC_007414.1 65583 66113 R 20 pct identical (2 gaps) to 96 residues of a 271 aa protein YG5W_YEAST SW: P53335; hypothetical protein complement(65583..66113) Escherichia coli O157:H7 str. EDL933 3683684 YP_325640.1 CDS L7080 NC_007414.1 66627 66887 R 40 pct identical (1 gaps) to 42 residues of a 1051 aa protein EVI1_HUMAN SW: Q03112; hypothetical protein complement(66627..66887) Escherichia coli O157:H7 str. EDL933 3683685 YP_325641.1 CDS L7081 NC_007414.1 66891 68252 D 27 pct identical to 67 residues of a 296 aa protein FIMP TRSW: Q46527; hypothetical protein 66891..68252 Escherichia coli O157:H7 str. EDL933 3683686 YP_325642.1 CDS L7082 NC_007414.1 68299 68862 D 29 pct identical (3 gaps) to 139 residues of a 311 aa protein MYRB_MICGR SW: P43433; hypothetical protein 68299..68862 Escherichia coli O157:H7 str. EDL933 3683655 YP_325643.1 CDS L7083 NC_007414.1 68948 69403 R 25 pct identical (1 gaps) to 106 residues of a 1807 aa protein VTA2_XENLA SW: P18709; hypothetical protein complement(68948..69403) Escherichia coli O157:H7 str. EDL933 3683656 YP_325644.1 CDS ssb NC_007414.1 69666 70157 D 95 pct identical (0 gaps) to 141 residues of a 179 aa protein SSBF_ECOLI SW: P18310; single-stranded DNA-binding protein 69666..70157 Escherichia coli O157:H7 str. EDL933 3683657 YP_325645.1 CDS L7085 NC_007414.1 70187 70447 D 57 pct identical (1 gaps) to 65 residues of a 80 aa protein TRSW: P75677; hypothetical protein 70187..70447 Escherichia coli O157:H7 str. EDL933 3683658 YP_325646.2 CDS L7086 NC_007414.1 70513 72471 D 99 pct identical (0 gaps) and equal length to a 83 aa protein, putative ORF1 TRSW: P96030; hypothetical protein 70513..72471 Escherichia coli O157:H7 str. EDL933 3683659 YP_325647.1 CDS psiB NC_007414.1 72523 72960 D 97 pct identical amino acid sequence and equal length to PSB1_ECOLI SW: P10031; plasmid SOS inhibition protein B 72523..72960 Escherichia coli O157:H7 str. EDL933 3683660 YP_325648.1 CDS psiA NC_007414.1 72957 73718 D PsiA; plasmid SOS inhibition protein A 72957..73718 Escherichia coli O157:H7 str. EDL933 3683661 YP_325649.1 CDS flmC NC_007414.1 73892 74104 D Mok; similar to F leading maintenance protein C; modulator of post-segregation killing protein 73892..74104 Escherichia coli O157:H7 str. EDL933 3683663 YP_325650.1 CDS flmA NC_007414.1 73950 74108 D 100 pct identical and equal length to an 52 aa protein FLMA_ECOLI, SW: P16077; small toxic polypeptide 73950..74108 Escherichia coli O157:H7 str. EDL933 3683664 YP_325651.1 CDS L7091 NC_007414.1 74290 76263 D 70 pct identical (3 gaps) to 655 residues of an approx. 904 aa protein Q52336 TRSW: Q52336; putative nickase 74290..76263 Escherichia coli O157:H7 str. EDL933 3683665 YP_325652.1 CDS L7092 NC_007414.1 76331 76762 D 34 pct identical (0 gaps) to 77 residues of an approx. 421 aa protein TOLA_ECOLI SW: P19934; hypothetical protein 76331..76762 Escherichia coli O157:H7 str. EDL933 3683666 YP_325653.1 CDS L7093 NC_007414.1 77322 77681 R 77 pct identical (1 gaps) to 91 residues of an approx. 288 aa protein TRA5_ECOLI SW: P05822, IS3; putative transposase complement(77322..77681) Escherichia coli O157:H7 str. EDL933 3683667 YP_325654.1 CDS L7094 NC_007414.1 77863 78273 D 70 pct identical (3 gaps) to 120 residues of an approx. 390 aa protein ISTA_ECOLI SW: P15025, IS21; transposase 77863..78273 Escherichia coli O157:H7 str. EDL933 3683648 YP_325655.1 CDS L7095 NC_007414.1 78542 88051 D 22 pct identical (44 gaps) to 444 residues of an approx. 2364 aa protein Clostridium sordellii cytotoxin L TRSW: Q46342; putative cytotoxin 78542..88051 Escherichia coli O157:H7 str. EDL933 3683649 YP_325656.1 CDS L7096 NC_007414.1 88143 88415 D 85 pct identical (0 gaps) to 68 residues of an approx. 288 aa protein TRA5_ECOLI SW: P05822, IS3; putative transposase 88143..88415 Escherichia coli O157:H7 str. EDL933 3683650 YP_325657.1 CDS L7097 NC_007414.1 88342 88845 R 96 pct identical (0 gaps) to 84 residues of an approx. 108 aa protein YIS3_SHISO SW: P16941, IS629; hypothetical protein complement(88342..88845) Escherichia coli O157:H7 str. EDL933 3683651 YP_325658.1 CDS traI NC_007414.1 88992 90290 D 96 pct identical to 432 residues of a 1756 aa protein TRI1_ECOLI SW: P14565, truncated by insertion of IS629; DNA helicase 88992..90290 Escherichia coli O157:H7 str. EDL933 3683652 YP_325659.1 CDS traX NC_007414.1 90310 91056 D 94 pct identical and equal length to TRX1_ECOLI SW: P22709; conjugal transfer pilus acetylation protein TraX 90310..91056 Escherichia coli O157:H7 str. EDL933 3683653 YP_325660.1 CDS ypt2 NC_007414.1 91115 91975 D 31.7 kDa protein in traX-finO intergenic region; 96 pct identical amino acid sequence and equal length to YPT2_ECOLI SW: Q99390; hypothetical protein 91115..91975 Escherichia coli O157:H7 str. EDL933 3683654 Z0217 tRNA ileV NC_002655.2 228713 228789 D tRNA-Ile 228713..228789 Escherichia coli O157:H7 str. EDL933 956947 Z0218 tRNA alaV NC_002655.2 228832 228907 D tRNA-Ala 228832..228907 Escherichia coli O157:H7 str. EDL933 956953 Z0228 tRNA aspU NC_002655.2 232258 232334 D tRNA-Asp 232258..232334 Escherichia coli O157:H7 str. EDL933 956969 Z0242 tRNA aspV NC_002655.2 240482 240558 D tRNA-Asp 240482..240558 Escherichia coli O157:H7 str. EDL933 956981 Z0305 tRNA thrW NC_002655.2 299983 300058 D tRNA-Thr 299983..300058 Escherichia coli O157:H7 str. EDL933 957069 Z0422 tRNA Z0422 NC_002655.2 402035 402115 D tRNA-OTHER 402035..402115 Escherichia coli O157:H7 str. EDL933 957250 Z0695 tRNA argU NC_002655.2 656876 656952 D tRNA-Arg 656876..656952 Escherichia coli O157:H7 str. EDL933 957548 Z0813 tRNA glnX NC_002655.2 776372 776446 R tRNA-Gln complement(776372..776446) Escherichia coli O157:H7 str. EDL933 957726 Z0814 tRNA glnV NC_002655.2 776484 776558 R tRNA-Gln complement(776484..776558) Escherichia coli O157:H7 str. EDL933 957728 Z0815 tRNA metU NC_002655.2 776607 776683 R tRNA-Met complement(776607..776683) Escherichia coli O157:H7 str. EDL933 957729 Z0816 tRNA glnW NC_002655.2 776699 776773 R tRNA-Gln complement(776699..776773) Escherichia coli O157:H7 str. EDL933 957731 Z0817 tRNA glnU NC_002655.2 776808 776882 R tRNA-Gln complement(776808..776882) Escherichia coli O157:H7 str. EDL933 957732 Z0819 tRNA leuW NC_002655.2 776906 776990 R tRNA-Leu complement(776906..776990) Escherichia coli O157:H7 str. EDL933 957733 Z0820 tRNA metT NC_002655.2 777001 777077 R tRNA-Met complement(777001..777077) Escherichia coli O157:H7 str. EDL933 957736 Z0911 tRNA lysT NC_002655.2 866633 866708 D tRNA-Lys 866633..866708 Escherichia coli O157:H7 str. EDL933 957877 Z0912 tRNA valT NC_002655.2 866744 866819 D tRNA-Val 866744..866819 Escherichia coli O157:H7 str. EDL933 957878 Z0913 tRNA lysW NC_002655.2 866822 866897 D tRNA-Lys 866822..866897 Escherichia coli O157:H7 str. EDL933 957882 Z0914 tRNA valZ NC_002655.2 866949 867024 D tRNA-Val 866949..867024 Escherichia coli O157:H7 str. EDL933 957885 Z0915 tRNA lysY NC_002655.2 867028 867103 D tRNA-Lys 867028..867103 Escherichia coli O157:H7 str. EDL933 957886 Z0917 tRNA lysZ NC_002655.2 867250 867325 D tRNA-Lys 867250..867325 Escherichia coli O157:H7 str. EDL933 957888 Z1227 tRNA serW NC_002655.2 1146184 1146271 R tRNA-Ser complement(1146184..1146271) Escherichia coli O157:H7 str. EDL933 958837 Z1388 tRNA serT NC_002655.2 1295563 1295650 R tRNA-Ser complement(1295563..1295650) Escherichia coli O157:H7 str. EDL933 959034 Z1461 tRNA ileZ NC_002655.2 1351948 1352023 D tRNA-Ile 1351948..1352023 Escherichia coli O157:H7 str. EDL933 959103 Z1462 tRNA argN NC_002655.2 1352033 1352109 D tRNA-Arg 1352033..1352109 Escherichia coli O157:H7 str. EDL933 959104 Z1463 tRNA argO NC_002655.2 1352123 1352199 D tRNA-Arg 1352123..1352199 Escherichia coli O157:H7 str. EDL933 959105 Z1665 tRNA serX NC_002655.2 1541790 1541877 R tRNA-Ser complement(1541790..1541877) Escherichia coli O157:H7 str. EDL933 959357 Z1790 tRNA Z1790 NC_002655.2 1640997 1641072 D tRNA-Ile 1640997..1641072 Escherichia coli O157:H7 str. EDL933 959518 Z1792 tRNA Z1792 NC_002655.2 1641170 1641246 D tRNA-Arg 1641170..1641246 Escherichia coli O157:H7 str. EDL933 959523 Z2006 tRNA tyrV NC_002655.2 1824225 1824309 R tRNA-Tyr complement(1824225..1824309) Escherichia coli O157:H7 str. EDL933 960482 Z2007 tRNA tyrT NC_002655.2 1824519 1824603 R tRNA-Tyr complement(1824519..1824603) Escherichia coli O157:H7 str. EDL933 960483 Z2061 tRNA Z2061 NC_002655.2 1865882 1865957 D tRNA-Ile 1865882..1865957 Escherichia coli O157:H7 str. EDL933 960532 Z2062 tRNA Z2062 NC_002655.2 1866038 1866114 D tRNA-Arg 1866038..1866114 Escherichia coli O157:H7 str. EDL933 960533 Z2380 tRNA Z2380 NC_002655.2 2146344 2146420 R tRNA-Arg complement(2146344..2146420) Escherichia coli O157:H7 str. EDL933 961120 Z2381 tRNA Z2381 NC_002655.2 2146521 2146596 R tRNA-Ile complement(2146521..2146596) Escherichia coli O157:H7 str. EDL933 961123 Z6057 tRNA Z6057 NC_002655.2 2315774 2315847 R tRNA-Arg complement(2315774..2315847) Escherichia coli O157:H7 str. EDL933 961479 Z6058 tRNA Z6058 NC_002655.2 2315864 2315937 R tRNA-Arg complement(2315864..2315937) Escherichia coli O157:H7 str. EDL933 961481 Z6059 tRNA Z6059 NC_002655.2 2315948 2316020 R tRNA-Ile complement(2315948..2316020) Escherichia coli O157:H7 str. EDL933 961482 Z2692 tRNA valV NC_002655.2 2421342 2421418 D tRNA-Val 2421342..2421418 Escherichia coli O157:H7 str. EDL933 961634 Z2693 tRNA valW NC_002655.2 2421423 2421499 D tRNA-Val 2421423..2421499 Escherichia coli O157:H7 str. EDL933 961636 Z2997 tRNA leuZ NC_002655.2 2689298 2689384 R tRNA-Leu complement(2689298..2689384) Escherichia coli O157:H7 str. EDL933 961907 Z2998 tRNA cysT NC_002655.2 2689397 2689470 R tRNA-Cys complement(2689397..2689470) Escherichia coli O157:H7 str. EDL933 961908 Z2999 tRNA glyW NC_002655.2 2689524 2689599 R tRNA-Gly complement(2689524..2689599) Escherichia coli O157:H7 str. EDL933 961909 Z3110 tRNA Z3110 NC_002655.2 2774120 2774196 R tRNA-Arg complement(2774120..2774196) Escherichia coli O157:H7 str. EDL933 962014 Z3112 tRNA Z3112 NC_002655.2 2774210 2774286 R tRNA-Arg complement(2774210..2774286) Escherichia coli O157:H7 str. EDL933 962015 Z3113 tRNA Z3113 NC_002655.2 2774294 2774369 R tRNA-Ile complement(2774294..2774369) Escherichia coli O157:H7 str. EDL933 962016 Z3131 tRNA serU NC_002655.2 2788401 2788490 R tRNA-Ser complement(2788401..2788490) Escherichia coli O157:H7 str. EDL933 962034 Z3133 tRNA asnT NC_002655.2 2789482 2789557 D tRNA-Asn 2789482..2789557 Escherichia coli O157:H7 str. EDL933 962036 Z3141 tRNA asnW NC_002655.2 2803862 2803937 R tRNA-Asn complement(2803862..2803937) Escherichia coli O157:H7 str. EDL933 962043 Z3145 tRNA asnU NC_002655.2 2805686 2805761 D tRNA-Asn 2805686..2805761 Escherichia coli O157:H7 str. EDL933 962046 Z3149 tRNA asnV NC_002655.2 2808094 2808169 D tRNA-Asn 2808094..2808169 Escherichia coli O157:H7 str. EDL933 962049 Z3448 tRNA proL NC_002655.2 3092410 3092486 D tRNA-Pro 3092410..3092486 Escherichia coli O157:H7 str. EDL933 957338 Z3612 tRNA argW NC_002655.2 3262864 3262938 D tRNA-Arg 3262864..3262938 Escherichia coli O157:H7 str. EDL933 958923 Z3661 tRNA alaX NC_002655.2 3314784 3314859 R tRNA-Ala complement(3314784..3314859) Escherichia coli O157:H7 str. EDL933 957605 Z3667 tRNA valU NC_002655.2 3319306 3319381 D tRNA-Val 3319306..3319381 Escherichia coli O157:H7 str. EDL933 957616 Z3668 tRNA valX NC_002655.2 3319426 3319501 D tRNA-Val 3319426..3319501 Escherichia coli O157:H7 str. EDL933 958163 Z3669 tRNA valY NC_002655.2 3319548 3319623 D tRNA-Val 3319548..3319623 Escherichia coli O157:H7 str. EDL933 958153 Z3670 tRNA lysV NC_002655.2 3319628 3319703 D tRNA-Lys 3319628..3319703 Escherichia coli O157:H7 str. EDL933 957622 Z3881 tRNA gltW NC_002655.2 3519417 3519492 R tRNA-Glu complement(3519417..3519492) Escherichia coli O157:H7 str. EDL933 957996 Z3952 tRNA ileY NC_002655.2 3575237 3575312 R tRNA-Ile complement(3575237..3575312) Escherichia coli O157:H7 str. EDL933 957345 Z3992 tRNA argQ NC_002655.2 3609232 3609308 R tRNA-Arg complement(3609232..3609308) Escherichia coli O157:H7 str. EDL933 958140 Z3993 tRNA argZ NC_002655.2 3609411 3609487 R tRNA-Arg complement(3609411..3609487) Escherichia coli O157:H7 str. EDL933 960803 Z3995 tRNA argY NC_002655.2 3609550 3609626 R tRNA-Arg complement(3609550..3609626) Escherichia coli O157:H7 str. EDL933 958073 Z3996 tRNA argV NC_002655.2 3609691 3609767 R tRNA-Arg complement(3609691..3609767) Escherichia coli O157:H7 str. EDL933 958144 Z3997 tRNA serV NC_002655.2 3609771 3609864 R tRNA-Ser complement(3609771..3609864) Escherichia coli O157:H7 str. EDL933 958150 Z4131 tRNA metZ NC_002655.2 3737085 3737161 D tRNA-Met 3737085..3737161 Escherichia coli O157:H7 str. EDL933 958285 Z4132 tRNA metW NC_002655.2 3737195 3737271 D tRNA-Met 3737195..3737271 Escherichia coli O157:H7 str. EDL933 958287 Z4133 tRNA metV NC_002655.2 3737305 3737381 D tRNA-Met 3737305..3737381 Escherichia coli O157:H7 str. EDL933 957730 Z4202 tRNA glyU NC_002655.2 3804619 3804692 R tRNA-Gly complement(3804619..3804692) Escherichia coli O157:H7 str. EDL933 958497 Z4312 tRNA pheV NC_002655.2 3919272 3919347 D tRNA-Phe 3919272..3919347 Escherichia coli O157:H7 str. EDL933 958443 Z4422 tRNA ileX NC_002655.2 4022444 4022519 D tRNA-Ile 4022444..4022519 Escherichia coli O157:H7 str. EDL933 958540 Z4532 tRNA metY NC_002655.2 4127927 4128003 R tRNA-Met complement(4127927..4128003) Escherichia coli O157:H7 str. EDL933 958615 Z4536 tRNA leuU NC_002655.2 4131786 4131872 R tRNA-Leu complement(4131786..4131872) Escherichia coli O157:H7 str. EDL933 958618 Z4635 tRNA thrV NC_002655.2 4225803 4225878 R tRNA-Thr complement(4225803..4225878) Escherichia coli O157:H7 str. EDL933 958718 Z4643 tRNA alaU NC_002655.2 4229193 4229268 R tRNA-Ala complement(4229193..4229268) Escherichia coli O157:H7 str. EDL933 958660 Z4644 tRNA ileU NC_002655.2 4229311 4229387 R tRNA-Ile complement(4229311..4229387) Escherichia coli O157:H7 str. EDL933 961466 Z4963 tRNA proK NC_002655.2 4517666 4517742 R tRNA-Pro complement(4517666..4517742) Escherichia coli O157:H7 str. EDL933 961073 Z5086 tRNA selC NC_002655.2 4649752 4649842 D tRNA-Sec 4649752..4649842 Escherichia coli O157:H7 str. EDL933 960886 Z5263 tRNA gltU NC_002655.2 4805859 4805934 D tRNA-Glu 4805859..4805934 Escherichia coli O157:H7 str. EDL933 960409 Z5273 tRNA aspT NC_002655.2 4809297 4809373 D tRNA-Asp 4809297..4809373 Escherichia coli O157:H7 str. EDL933 960406 Z5274 tRNA trpT NC_002655.2 4809382 4809457 D tRNA-Trp 4809382..4809457 Escherichia coli O157:H7 str. EDL933 960405 Z5308 tRNA argX NC_002655.2 4844766 4844842 D tRNA-Arg 4844766..4844842 Escherichia coli O157:H7 str. EDL933 960369 Z5310 tRNA hisR NC_002655.2 4844900 4844976 D tRNA-His 4844900..4844976 Escherichia coli O157:H7 str. EDL933 960367 Z5311 tRNA leuT NC_002655.2 4844997 4845083 D tRNA-Leu 4844997..4845083 Escherichia coli O157:H7 str. EDL933 960366 Z5312 tRNA proM NC_002655.2 4845126 4845202 D tRNA-Pro 4845126..4845202 Escherichia coli O157:H7 str. EDL933 960365 Z5377 tRNA ileT NC_002655.2 4902028 4902104 D tRNA-Ile 4902028..4902104 Escherichia coli O157:H7 str. EDL933 960308 Z5378 tRNA alaT NC_002655.2 4902147 4902222 D tRNA-Ala 4902147..4902222 Escherichia coli O157:H7 str. EDL933 960307 Z5533 tRNA gltT NC_002655.2 5046317 5046392 D tRNA-Glu 5046317..5046392 Escherichia coli O157:H7 str. EDL933 960161 Z5548 tRNA thrU NC_002655.2 5053151 5053226 D tRNA-Thr 5053151..5053226 Escherichia coli O157:H7 str. EDL933 960154 Z5550 tRNA tyrU NC_002655.2 5053235 5053319 D tRNA-Tyr 5053235..5053319 Escherichia coli O157:H7 str. EDL933 960153 Z5551 tRNA glyT NC_002655.2 5053436 5053510 D tRNA-Gly 5053436..5053510 Escherichia coli O157:H7 str. EDL933 960152 Z5552 tRNA thrT NC_002655.2 5053517 5053592 D tRNA-Thr 5053517..5053592 Escherichia coli O157:H7 str. EDL933 960151 Z5588 tRNA gltV NC_002655.2 5087326 5087401 D tRNA-Glu 5087326..5087401 Escherichia coli O157:H7 str. EDL933 960121 Z5738 tRNA pheU NC_002655.2 5246987 5247062 R tRNA-Phe complement(5246987..5247062) Escherichia coli O157:H7 str. EDL933 959989 Z5770 tRNA glyV NC_002655.2 5276070 5276145 D tRNA-Gly 5276070..5276145 Escherichia coli O157:H7 str. EDL933 959960 Z5771 tRNA glyX NC_002655.2 5276182 5276257 D tRNA-Gly 5276182..5276257 Escherichia coli O157:H7 str. EDL933 959959 Z5772 tRNA glyY NC_002655.2 5276293 5276368 D tRNA-Gly 5276293..5276368 Escherichia coli O157:H7 str. EDL933 959958 Z5877 tRNA leuX NC_002655.2 5377002 5377086 D tRNA-Leu 5377002..5377086 Escherichia coli O157:H7 str. EDL933 959772 Z5971 tRNA leuV NC_002655.2 5494433 5494519 R tRNA-Leu complement(5494433..5494519) Escherichia coli O157:H7 str. EDL933 959685 Z0213 rRNA rrsH NC_002655.2 227103 228644 D 16S ribosomal RNA 227103..228644 Escherichia coli O157:H7 str. EDL933 956946 Z0219 rRNA rrlH NC_002655.2 229091 231993 D 23S ribosomal RNA 229091..231993 Escherichia coli O157:H7 str. EDL933 956961 Z0226 rRNA rrfH NC_002655.2 232086 232205 D 5S ribosomal RNA 232086..232205 Escherichia coli O157:H7 str. EDL933 956964 Z3874 rRNA rrfG NC_002655.2 3516104 3516223 R 5S ribosomal RNA complement(3516104..3516223) Escherichia coli O157:H7 str. EDL933 957990 Z3875 rRNA rrlG NC_002655.2 3516316 3519223 R 23S ribosomal RNA complement(3516316..3519223) Escherichia coli O157:H7 str. EDL933 957993 Z3882 rRNA rrsG NC_002655.2 3519578 3521124 R 16S ribosomal RNA complement(3519578..3521124) Escherichia coli O157:H7 str. EDL933 958002 Z4633 rRNA rrfF NC_002655.2 4225646 4225765 R 5S ribosomal RNA complement(4225646..4225765) Escherichia coli O157:H7 str. EDL933 958610 Z4636 rRNA rrfD NC_002655.2 4225891 4226010 R 5S ribosomal RNA complement(4225891..4226010) Escherichia coli O157:H7 str. EDL933 958723 Z4637 rRNA rrlD NC_002655.2 4226104 4229009 R 23S ribosomal RNA complement(4226104..4229009) Escherichia coli O157:H7 str. EDL933 958724 Z4645 rRNA rrsD NC_002655.2 4229456 4230997 R 16S ribosomal RNA complement(4229456..4230997) Escherichia coli O157:H7 str. EDL933 958725 Z5259 rRNA rrsC NC_002655.2 4804233 4805773 D 16S ribosomal RNA 4804233..4805773 Escherichia coli O157:H7 str. EDL933 960410 Z5264 rRNA rrlC NC_002655.2 4806128 4809032 D 23S ribosomal RNA 4806128..4809032 Escherichia coli O157:H7 str. EDL933 960408 Z5271 rRNA rrfC NC_002655.2 4809125 4809244 D 5S ribosomal RNA 4809125..4809244 Escherichia coli O157:H7 str. EDL933 960407 Z5373 rRNA rrsA NC_002655.2 4900418 4901959 D 16S ribosomal RNA 4900418..4901959 Escherichia coli O157:H7 str. EDL933 960309 Z5379 rRNA rrlA NC_002655.2 4902406 4905310 D 23S ribosomal RNA 4902406..4905310 Escherichia coli O157:H7 str. EDL933 960306 Z5386 rRNA rrfA NC_002655.2 4905403 4905522 D 5S ribosomal RNA 4905403..4905522 Escherichia coli O157:H7 str. EDL933 960305 Z5529 rRNA rrsB NC_002655.2 5044690 5046231 D 16S ribosomal RNA 5044690..5046231 Escherichia coli O157:H7 str. EDL933 960162 Z5534 rRNA rrlB NC_002655.2 5046586 5049490 D 23S ribosomal RNA 5046586..5049490 Escherichia coli O157:H7 str. EDL933 960160 Z5541 rRNA rrfB NC_002655.2 5049583 5049702 D 5S ribosomal RNA 5049583..5049702 Escherichia coli O157:H7 str. EDL933 960159 Z5585 rRNA rrsE NC_002655.2 5085699 5087240 D 16S ribosomal RNA 5085699..5087240 Escherichia coli O157:H7 str. EDL933 960122 Z5589 rRNA rrlE NC_002655.2 5087595 5090497 D 23S ribosomal RNA 5087595..5090497 Escherichia coli O157:H7 str. EDL933 960120 Z5596 rRNA rrfE NC_002655.2 5090590 5090709 D 5S ribosomal RNA 5090590..5090709 Escherichia coli O157:H7 str. EDL933 960119