-- dump date 20140619_085815 -- class Genbank::misc_feature -- table misc_feature_note -- id note 155864000001 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 155864000002 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 155864000003 putative catalytic residues [active] 155864000004 putative nucleotide binding site [chemical binding]; other site 155864000005 putative aspartate binding site [chemical binding]; other site 155864000006 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 155864000007 dimer interface [polypeptide binding]; other site 155864000008 putative threonine allosteric regulatory site; other site 155864000009 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 155864000010 putative threonine allosteric regulatory site; other site 155864000011 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 155864000012 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 155864000013 homoserine kinase; Region: thrB; TIGR00191 155864000014 Protein of unknown function; Region: YhfT; pfam10797 155864000015 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 155864000016 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 155864000017 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 155864000018 pyridoxal 5'-phosphate binding site [chemical binding]; other site 155864000019 catalytic residue [active] 155864000020 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 155864000021 hypothetical protein; Validated; Region: PRK02101 155864000022 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 155864000023 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 155864000024 transaldolase-like protein; Provisional; Region: PTZ00411 155864000025 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 155864000026 active site 155864000027 dimer interface [polypeptide binding]; other site 155864000028 catalytic residue [active] 155864000029 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 155864000030 MPT binding site; other site 155864000031 trimer interface [polypeptide binding]; other site 155864000032 hypothetical protein; Provisional; Region: PRK10659 155864000033 hypothetical protein; Provisional; Region: PRK10236 155864000034 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 155864000035 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 155864000036 hypothetical protein; Provisional; Region: PRK10154 155864000037 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 155864000038 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 155864000039 nucleotide binding site [chemical binding]; other site 155864000040 NEF interaction site [polypeptide binding]; other site 155864000041 SBD interface [polypeptide binding]; other site 155864000042 chaperone protein DnaJ; Provisional; Region: PRK10767 155864000043 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 155864000044 HSP70 interaction site [polypeptide binding]; other site 155864000045 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 155864000046 substrate binding site [polypeptide binding]; other site 155864000047 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 155864000048 Zn binding sites [ion binding]; other site 155864000049 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 155864000050 dimer interface [polypeptide binding]; other site 155864000051 Hok/gef family; Region: HOK_GEF; pfam01848 155864000052 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 155864000053 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 155864000054 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 155864000055 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 155864000056 putative dimerization interface [polypeptide binding]; other site 155864000057 O-island #1; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864000058 fimbrial outer membrane usher protein; Provisional; Region: PRK15217 155864000059 PapC N-terminal domain; Region: PapC_N; pfam13954 155864000060 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 155864000061 PapC C-terminal domain; Region: PapC_C; pfam13953 155864000062 putative fimbrial assembly chaperone protein StcB; Provisional; Region: PRK15253 155864000063 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 155864000064 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 155864000065 Fimbrial protein; Region: Fimbrial; cl01416 155864000066 O-island #1; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864000067 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 155864000068 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 155864000069 Protein of unknown function (DUF2575); Region: DUF2575; pfam10837 155864000070 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 155864000071 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 155864000072 active site 155864000073 Riboflavin kinase; Region: Flavokinase; smart00904 155864000074 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 155864000075 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 155864000076 HIGH motif; other site 155864000077 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 155864000078 active site 155864000079 KMSKS motif; other site 155864000080 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 155864000081 tRNA binding surface [nucleotide binding]; other site 155864000082 anticodon binding site; other site 155864000083 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 155864000084 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 155864000085 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 155864000086 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 155864000087 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 155864000088 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 155864000089 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 155864000090 active site 155864000091 tetramer interface [polypeptide binding]; other site 155864000092 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 155864000093 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 155864000094 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 155864000095 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 155864000096 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 155864000097 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 155864000098 catalytic site [active] 155864000099 subunit interface [polypeptide binding]; other site 155864000100 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 155864000101 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 155864000102 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 155864000103 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 155864000104 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 155864000105 ATP-grasp domain; Region: ATP-grasp_4; cl17255 155864000106 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 155864000107 IMP binding site; other site 155864000108 dimer interface [polypeptide binding]; other site 155864000109 interdomain contacts; other site 155864000110 partial ornithine binding site; other site 155864000111 DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476 155864000112 carnitine operon protein CaiE; Provisional; Region: PRK13627 155864000113 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 155864000114 putative trimer interface [polypeptide binding]; other site 155864000115 putative metal binding site [ion binding]; other site 155864000116 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 155864000117 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 155864000118 substrate binding site [chemical binding]; other site 155864000119 oxyanion hole (OAH) forming residues; other site 155864000120 trimer interface [polypeptide binding]; other site 155864000121 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 155864000122 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 155864000123 acyl-activating enzyme (AAE) consensus motif; other site 155864000124 putative AMP binding site [chemical binding]; other site 155864000125 putative active site [active] 155864000126 putative CoA binding site [chemical binding]; other site 155864000127 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 155864000128 CoA-transferase family III; Region: CoA_transf_3; pfam02515 155864000129 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 155864000130 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 155864000131 active site 155864000132 L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356 155864000133 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 155864000134 Ligand binding site [chemical binding]; other site 155864000135 Electron transfer flavoprotein domain; Region: ETF; pfam01012 155864000136 putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363 155864000137 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985 155864000138 Ligand binding site [chemical binding]; other site 155864000139 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 155864000140 putative oxidoreductase FixC; Provisional; Region: PRK10157 155864000141 ferredoxin-like protein FixX; Provisional; Region: PRK15449 155864000142 benzoate transport; Region: 2A0115; TIGR00895 155864000143 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864000144 putative substrate translocation pore; other site 155864000145 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 155864000146 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 155864000147 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 155864000148 TrkA-N domain; Region: TrkA_N; pfam02254 155864000149 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 155864000150 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 155864000151 folate binding site [chemical binding]; other site 155864000152 NADP+ binding site [chemical binding]; other site 155864000153 O-island #2; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864000154 O-island #2; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864000155 Post-segregation antitoxin CcdA; Region: CcdA; pfam07362 155864000156 CcdB protein; Region: CcdB; pfam01845 155864000157 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 155864000158 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 155864000159 active site 155864000160 metal binding site [ion binding]; metal-binding site 155864000161 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 155864000162 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 155864000163 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 155864000164 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 155864000165 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 155864000166 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 155864000167 SurA N-terminal domain; Region: SurA_N; pfam09312 155864000168 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 155864000169 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 155864000170 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 155864000171 OstA-like protein; Region: OstA; pfam03968 155864000172 Organic solvent tolerance protein; Region: OstA_C; pfam04453 155864000173 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 155864000174 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 155864000175 putative metal binding site [ion binding]; other site 155864000176 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 155864000177 HSP70 interaction site [polypeptide binding]; other site 155864000178 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 155864000179 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 155864000180 active site 155864000181 ATP-dependent helicase HepA; Validated; Region: PRK04914 155864000182 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 155864000183 ATP binding site [chemical binding]; other site 155864000184 putative Mg++ binding site [ion binding]; other site 155864000185 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 155864000186 nucleotide binding region [chemical binding]; other site 155864000187 ATP-binding site [chemical binding]; other site 155864000188 DNA polymerase II; Reviewed; Region: PRK05762 155864000189 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 155864000190 active site 155864000191 catalytic site [active] 155864000192 substrate binding site [chemical binding]; other site 155864000193 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 155864000194 active site 155864000195 metal-binding site 155864000196 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 155864000197 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 155864000198 intersubunit interface [polypeptide binding]; other site 155864000199 active site 155864000200 Zn2+ binding site [ion binding]; other site 155864000201 L-arabinose isomerase; Provisional; Region: PRK02929 155864000202 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 155864000203 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 155864000204 trimer interface [polypeptide binding]; other site 155864000205 putative substrate binding site [chemical binding]; other site 155864000206 putative metal binding site [ion binding]; other site 155864000207 ribulokinase; Provisional; Region: PRK04123 155864000208 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 155864000209 N- and C-terminal domain interface [polypeptide binding]; other site 155864000210 active site 155864000211 MgATP binding site [chemical binding]; other site 155864000212 catalytic site [active] 155864000213 metal binding site [ion binding]; metal-binding site 155864000214 carbohydrate binding site [chemical binding]; other site 155864000215 homodimer interface [polypeptide binding]; other site 155864000216 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 155864000217 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 155864000218 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 155864000219 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 155864000220 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 155864000221 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 155864000222 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 155864000223 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 155864000224 Walker A/P-loop; other site 155864000225 ATP binding site [chemical binding]; other site 155864000226 Q-loop/lid; other site 155864000227 ABC transporter signature motif; other site 155864000228 Walker B; other site 155864000229 D-loop; other site 155864000230 H-loop/switch region; other site 155864000231 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 155864000232 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 155864000233 dimer interface [polypeptide binding]; other site 155864000234 conserved gate region; other site 155864000235 putative PBP binding loops; other site 155864000236 ABC-ATPase subunit interface; other site 155864000237 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 155864000238 dimer interface [polypeptide binding]; other site 155864000239 conserved gate region; other site 155864000240 putative PBP binding loops; other site 155864000241 ABC-ATPase subunit interface; other site 155864000242 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 155864000243 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 155864000244 O-island #3; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864000245 O-island #3; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864000246 transcriptional regulator SgrR; Provisional; Region: PRK13626 155864000247 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 155864000248 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 155864000249 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 155864000250 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 155864000251 substrate binding site [chemical binding]; other site 155864000252 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 155864000253 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 155864000254 substrate binding site [chemical binding]; other site 155864000255 ligand binding site [chemical binding]; other site 155864000256 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 155864000257 tartrate dehydrogenase; Region: TTC; TIGR02089 155864000258 2-isopropylmalate synthase; Validated; Region: PRK00915 155864000259 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 155864000260 active site 155864000261 catalytic residues [active] 155864000262 metal binding site [ion binding]; metal-binding site 155864000263 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 155864000264 leu operon leader peptide; Provisional; Region: PRK09925 155864000265 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 155864000266 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 155864000267 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 155864000268 putative substrate binding pocket [chemical binding]; other site 155864000269 putative dimerization interface [polypeptide binding]; other site 155864000270 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 155864000271 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 155864000272 PYR/PP interface [polypeptide binding]; other site 155864000273 dimer interface [polypeptide binding]; other site 155864000274 TPP binding site [chemical binding]; other site 155864000275 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 155864000276 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 155864000277 TPP-binding site [chemical binding]; other site 155864000278 dimer interface [polypeptide binding]; other site 155864000279 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 155864000280 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 155864000281 putative valine binding site [chemical binding]; other site 155864000282 dimer interface [polypeptide binding]; other site 155864000283 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 155864000284 similar to fruR leader peptide 155864000285 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 155864000286 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 155864000287 DNA binding site [nucleotide binding] 155864000288 domain linker motif; other site 155864000289 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 155864000290 dimerization interface [polypeptide binding]; other site 155864000291 ligand binding site [chemical binding]; other site 155864000292 mraZ protein; Region: TIGR00242 155864000293 MraZ protein; Region: MraZ; pfam02381 155864000294 MraZ protein; Region: MraZ; pfam02381 155864000295 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 155864000296 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 155864000297 cell division protein FtsL; Provisional; Region: PRK10772 155864000298 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 155864000299 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 155864000300 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 155864000301 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 155864000302 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 155864000303 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 155864000304 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 155864000305 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 155864000306 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 155864000307 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 155864000308 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 155864000309 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 155864000310 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 155864000311 Mg++ binding site [ion binding]; other site 155864000312 putative catalytic motif [active] 155864000313 putative substrate binding site [chemical binding]; other site 155864000314 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 155864000315 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 155864000316 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 155864000317 cell division protein FtsW; Provisional; Region: PRK10774 155864000318 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 155864000319 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 155864000320 active site 155864000321 homodimer interface [polypeptide binding]; other site 155864000322 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 155864000323 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 155864000324 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 155864000325 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 155864000326 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 155864000327 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 155864000328 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 155864000329 cell division protein FtsQ; Provisional; Region: PRK10775 155864000330 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 155864000331 Cell division protein FtsQ; Region: FtsQ; pfam03799 155864000332 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 155864000333 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 155864000334 Cell division protein FtsA; Region: FtsA; pfam14450 155864000335 cell division protein FtsZ; Validated; Region: PRK09330 155864000336 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 155864000337 nucleotide binding site [chemical binding]; other site 155864000338 SulA interaction site; other site 155864000339 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 155864000340 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 155864000341 SecA regulator SecM; Provisional; Region: PRK02943 155864000342 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 155864000343 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 155864000344 SEC-C motif; Region: SEC-C; pfam02810 155864000345 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 155864000346 active site 155864000347 8-oxo-dGMP binding site [chemical binding]; other site 155864000348 nudix motif; other site 155864000349 metal binding site [ion binding]; metal-binding site 155864000350 DNA gyrase inhibitor; Reviewed; Region: PRK00418 155864000351 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 155864000352 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 155864000353 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 155864000354 CoA-binding site [chemical binding]; other site 155864000355 ATP-binding [chemical binding]; other site 155864000356 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 155864000357 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 155864000358 active site 155864000359 type IV pilin biogenesis protein; Provisional; Region: PRK10573 155864000360 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 155864000361 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 155864000362 hypothetical protein; Provisional; Region: PRK10436 155864000363 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 155864000364 Walker A motif; other site 155864000365 ATP binding site [chemical binding]; other site 155864000366 Walker B motif; other site 155864000367 putative major pilin subunit; Provisional; Region: PRK10574 155864000368 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 155864000369 Pilin (bacterial filament); Region: Pilin; pfam00114 155864000370 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 155864000371 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 155864000372 dimerization interface [polypeptide binding]; other site 155864000373 active site 155864000374 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 155864000375 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 155864000376 amidase catalytic site [active] 155864000377 Zn binding residues [ion binding]; other site 155864000378 substrate binding site [chemical binding]; other site 155864000379 regulatory protein AmpE; Provisional; Region: PRK10987 155864000380 aromatic amino acid transporter; Provisional; Region: PRK10238 155864000381 Transcriptional regulators [Transcription]; Region: FadR; COG2186 155864000382 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 155864000383 DNA-binding site [nucleotide binding]; DNA binding site 155864000384 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 155864000385 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 155864000386 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 155864000387 dimer interface [polypeptide binding]; other site 155864000388 TPP-binding site [chemical binding]; other site 155864000389 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 155864000390 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 155864000391 E3 interaction surface; other site 155864000392 lipoyl attachment site [posttranslational modification]; other site 155864000393 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 155864000394 E3 interaction surface; other site 155864000395 lipoyl attachment site [posttranslational modification]; other site 155864000396 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 155864000397 E3 interaction surface; other site 155864000398 lipoyl attachment site [posttranslational modification]; other site 155864000399 e3 binding domain; Region: E3_binding; pfam02817 155864000400 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 155864000401 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 155864000402 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 155864000403 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 155864000404 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 155864000405 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 155864000406 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 155864000407 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 155864000408 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 155864000409 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 155864000410 substrate binding site [chemical binding]; other site 155864000411 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 155864000412 substrate binding site [chemical binding]; other site 155864000413 ligand binding site [chemical binding]; other site 155864000414 hypothetical protein; Provisional; Region: PRK05248 155864000415 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 155864000416 spermidine synthase; Provisional; Region: PRK00811 155864000417 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 155864000418 S-adenosylmethionine binding site [chemical binding]; other site 155864000419 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 155864000420 multicopper oxidase; Provisional; Region: PRK10965 155864000421 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 155864000422 Multicopper oxidase; Region: Cu-oxidase; pfam00394 155864000423 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 155864000424 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 155864000425 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 155864000426 Trp docking motif [polypeptide binding]; other site 155864000427 putative active site [active] 155864000428 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 155864000429 active site 155864000430 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 155864000431 active site clefts [active] 155864000432 zinc binding site [ion binding]; other site 155864000433 dimer interface [polypeptide binding]; other site 155864000434 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 155864000435 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 155864000436 Walker A/P-loop; other site 155864000437 ATP binding site [chemical binding]; other site 155864000438 Q-loop/lid; other site 155864000439 ABC transporter signature motif; other site 155864000440 Walker B; other site 155864000441 D-loop; other site 155864000442 H-loop/switch region; other site 155864000443 inner membrane transport permease; Provisional; Region: PRK15066 155864000444 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 155864000445 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 155864000446 active pocket/dimerization site; other site 155864000447 active site 155864000448 phosphorylation site [posttranslational modification] 155864000449 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 155864000450 putative active site [active] 155864000451 putative metal binding site [ion binding]; other site 155864000452 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 155864000453 tetramerization interface [polypeptide binding]; other site 155864000454 active site 155864000455 Uncharacterized conserved protein [Function unknown]; Region: COG5464 155864000456 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 155864000457 O-island #4; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864000458 pantoate--beta-alanine ligase; Region: panC; TIGR00018 155864000459 Pantoate-beta-alanine ligase; Region: PanC; cd00560 155864000460 active site 155864000461 ATP-binding site [chemical binding]; other site 155864000462 pantoate-binding site; other site 155864000463 HXXH motif; other site 155864000464 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 155864000465 oligomerization interface [polypeptide binding]; other site 155864000466 active site 155864000467 metal binding site [ion binding]; metal-binding site 155864000468 Fimbrial protein; Region: Fimbrial; cl01416 155864000469 putative fimbrial protein StaF; Provisional; Region: PRK15262 155864000470 putative fimbrial protein StaE; Provisional; Region: PRK15263 155864000471 Fimbrial protein; Region: Fimbrial; cl01416 155864000472 putative fimbrial outer membrane usher protein; Provisional; Region: PRK09828 155864000473 PapC N-terminal domain; Region: PapC_N; pfam13954 155864000474 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 155864000475 PapC C-terminal domain; Region: PapC_C; pfam13953 155864000476 putative chaperone protein EcpD; Provisional; Region: PRK09926 155864000477 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 155864000478 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 155864000479 Fimbrial protein; Region: Fimbrial; cl01416 155864000480 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 155864000481 catalytic center binding site [active] 155864000482 ATP binding site [chemical binding]; other site 155864000483 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 155864000484 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 155864000485 active site 155864000486 NTP binding site [chemical binding]; other site 155864000487 metal binding triad [ion binding]; metal-binding site 155864000488 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 155864000489 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 155864000490 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 155864000491 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 155864000492 active site 155864000493 nucleotide binding site [chemical binding]; other site 155864000494 HIGH motif; other site 155864000495 KMSKS motif; other site 155864000496 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 155864000497 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 155864000498 2'-5' RNA ligase; Provisional; Region: PRK15124 155864000499 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 155864000500 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 155864000501 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 155864000502 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 155864000503 ATP binding site [chemical binding]; other site 155864000504 putative Mg++ binding site [ion binding]; other site 155864000505 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 155864000506 nucleotide binding region [chemical binding]; other site 155864000507 ATP-binding site [chemical binding]; other site 155864000508 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 155864000509 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 155864000510 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 155864000511 Transglycosylase; Region: Transgly; pfam00912 155864000512 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 155864000513 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 155864000514 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 155864000515 N-terminal plug; other site 155864000516 ligand-binding site [chemical binding]; other site 155864000517 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 155864000518 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 155864000519 Walker A/P-loop; other site 155864000520 ATP binding site [chemical binding]; other site 155864000521 Q-loop/lid; other site 155864000522 ABC transporter signature motif; other site 155864000523 Walker B; other site 155864000524 D-loop; other site 155864000525 H-loop/switch region; other site 155864000526 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 155864000527 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 155864000528 siderophore binding site; other site 155864000529 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 155864000530 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 155864000531 ABC-ATPase subunit interface; other site 155864000532 dimer interface [polypeptide binding]; other site 155864000533 putative PBP binding regions; other site 155864000534 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 155864000535 ABC-ATPase subunit interface; other site 155864000536 dimer interface [polypeptide binding]; other site 155864000537 putative PBP binding regions; other site 155864000538 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 155864000539 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 155864000540 inhibitor-cofactor binding pocket; inhibition site 155864000541 pyridoxal 5'-phosphate binding site [chemical binding]; other site 155864000542 catalytic residue [active] 155864000543 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 155864000544 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 155864000545 Cl- selectivity filter; other site 155864000546 Cl- binding residues [ion binding]; other site 155864000547 pore gating glutamate residue; other site 155864000548 dimer interface [polypeptide binding]; other site 155864000549 H+/Cl- coupling transport residue; other site 155864000550 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 155864000551 hypothetical protein; Provisional; Region: PRK10578 155864000552 UPF0126 domain; Region: UPF0126; pfam03458 155864000553 UPF0126 domain; Region: UPF0126; pfam03458 155864000554 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 155864000555 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 155864000556 cobalamin binding residues [chemical binding]; other site 155864000557 putative BtuC binding residues; other site 155864000558 dimer interface [polypeptide binding]; other site 155864000559 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 155864000560 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 155864000561 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 155864000562 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 155864000563 Zn2+ binding site [ion binding]; other site 155864000564 Mg2+ binding site [ion binding]; other site 155864000565 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 155864000566 serine endoprotease; Provisional; Region: PRK10942 155864000567 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 155864000568 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 155864000569 protein binding site [polypeptide binding]; other site 155864000570 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 155864000571 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 155864000572 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 155864000573 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 155864000574 hypothetical protein; Provisional; Region: PRK13677 155864000575 O-island #5; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864000576 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 155864000577 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 155864000578 trimer interface [polypeptide binding]; other site 155864000579 active site 155864000580 substrate binding site [chemical binding]; other site 155864000581 CoA binding site [chemical binding]; other site 155864000582 PII uridylyl-transferase; Provisional; Region: PRK05007 155864000583 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 155864000584 metal binding triad; other site 155864000585 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 155864000586 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 155864000587 Zn2+ binding site [ion binding]; other site 155864000588 Mg2+ binding site [ion binding]; other site 155864000589 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 155864000590 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 155864000591 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 155864000592 active site 155864000593 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 155864000594 rRNA interaction site [nucleotide binding]; other site 155864000595 S8 interaction site; other site 155864000596 putative laminin-1 binding site; other site 155864000597 elongation factor Ts; Provisional; Region: tsf; PRK09377 155864000598 UBA/TS-N domain; Region: UBA; pfam00627 155864000599 Elongation factor TS; Region: EF_TS; pfam00889 155864000600 Elongation factor TS; Region: EF_TS; pfam00889 155864000601 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 155864000602 putative nucleotide binding site [chemical binding]; other site 155864000603 uridine monophosphate binding site [chemical binding]; other site 155864000604 homohexameric interface [polypeptide binding]; other site 155864000605 ribosome recycling factor; Reviewed; Region: frr; PRK00083 155864000606 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 155864000607 hinge region; other site 155864000608 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 155864000609 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 155864000610 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 155864000611 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 155864000612 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 155864000613 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 155864000614 catalytic residue [active] 155864000615 putative FPP diphosphate binding site; other site 155864000616 putative FPP binding hydrophobic cleft; other site 155864000617 dimer interface [polypeptide binding]; other site 155864000618 putative IPP diphosphate binding site; other site 155864000619 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 155864000620 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 155864000621 zinc metallopeptidase RseP; Provisional; Region: PRK10779 155864000622 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 155864000623 active site 155864000624 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 155864000625 protein binding site [polypeptide binding]; other site 155864000626 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 155864000627 putative substrate binding region [chemical binding]; other site 155864000628 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 155864000629 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 155864000630 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 155864000631 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 155864000632 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 155864000633 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 155864000634 Surface antigen; Region: Bac_surface_Ag; pfam01103 155864000635 periplasmic chaperone; Provisional; Region: PRK10780 155864000636 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 155864000637 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 155864000638 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 155864000639 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 155864000640 trimer interface [polypeptide binding]; other site 155864000641 active site 155864000642 UDP-GlcNAc binding site [chemical binding]; other site 155864000643 lipid binding site [chemical binding]; lipid-binding site 155864000644 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 155864000645 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 155864000646 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 155864000647 active site 155864000648 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 155864000649 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 155864000650 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 155864000651 RNA/DNA hybrid binding site [nucleotide binding]; other site 155864000652 active site 155864000653 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 155864000654 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 155864000655 putative active site [active] 155864000656 putative PHP Thumb interface [polypeptide binding]; other site 155864000657 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 155864000658 generic binding surface II; other site 155864000659 generic binding surface I; other site 155864000660 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 155864000661 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 155864000662 lysine decarboxylase LdcC; Provisional; Region: PRK15399 155864000663 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 155864000664 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 155864000665 homodimer interface [polypeptide binding]; other site 155864000666 pyridoxal 5'-phosphate binding site [chemical binding]; other site 155864000667 catalytic residue [active] 155864000668 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 155864000669 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 155864000670 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 155864000671 putative metal binding site [ion binding]; other site 155864000672 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 155864000673 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 155864000674 Ligand Binding Site [chemical binding]; other site 155864000675 TilS substrate binding domain; Region: TilS; pfam09179 155864000676 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 155864000677 Rho-binding antiterminator; Provisional; Region: PRK11625 155864000678 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 155864000679 hypothetical protein; Provisional; Region: PRK09256 155864000680 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 155864000681 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 155864000682 NlpE N-terminal domain; Region: NlpE; pfam04170 155864000683 hypothetical protein; Provisional; Region: PRK11479 155864000684 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 155864000685 prolyl-tRNA synthetase; Provisional; Region: PRK09194 155864000686 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 155864000687 dimer interface [polypeptide binding]; other site 155864000688 motif 1; other site 155864000689 active site 155864000690 motif 2; other site 155864000691 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 155864000692 putative deacylase active site [active] 155864000693 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 155864000694 active site 155864000695 motif 3; other site 155864000696 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 155864000697 anticodon binding site; other site 155864000698 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 155864000699 homodimer interaction site [polypeptide binding]; other site 155864000700 cofactor binding site; other site 155864000701 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 155864000702 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 155864000703 lipoprotein, YaeC family; Region: TIGR00363 155864000704 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 155864000705 dimer interface [polypeptide binding]; other site 155864000706 conserved gate region; other site 155864000707 ABC-ATPase subunit interface; other site 155864000708 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 155864000709 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 155864000710 Walker A/P-loop; other site 155864000711 ATP binding site [chemical binding]; other site 155864000712 Q-loop/lid; other site 155864000713 ABC transporter signature motif; other site 155864000714 Walker B; other site 155864000715 D-loop; other site 155864000716 H-loop/switch region; other site 155864000717 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 155864000718 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 155864000719 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 155864000720 active site 155864000721 motif I; other site 155864000722 motif II; other site 155864000723 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 155864000724 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 155864000725 active site 155864000726 catalytic tetrad [active] 155864000727 Transcriptional regulator [Transcription]; Region: LysR; COG0583 155864000728 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 155864000729 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 155864000730 putative effector binding pocket; other site 155864000731 dimerization interface [polypeptide binding]; other site 155864000732 hypothetical protein; Provisional; Region: PRK05421 155864000733 putative catalytic site [active] 155864000734 putative metal binding site [ion binding]; other site 155864000735 putative phosphate binding site [ion binding]; other site 155864000736 putative catalytic site [active] 155864000737 putative phosphate binding site [ion binding]; other site 155864000738 putative metal binding site [ion binding]; other site 155864000739 O-island #6; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864000740 Methyltransferase domain; Region: Methyltransf_31; pfam13847 155864000741 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 155864000742 S-adenosylmethionine binding site [chemical binding]; other site 155864000743 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 155864000744 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 155864000745 N-acetyl-D-glucosamine binding site [chemical binding]; other site 155864000746 catalytic residue [active] 155864000747 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 155864000748 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 155864000749 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 155864000750 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 155864000751 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 155864000752 RNA/DNA hybrid binding site [nucleotide binding]; other site 155864000753 active site 155864000754 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 155864000755 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 155864000756 active site 155864000757 catalytic site [active] 155864000758 substrate binding site [chemical binding]; other site 155864000759 O-island #7; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864000760 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 155864000761 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 155864000762 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 155864000763 ImpA domain protein; Region: DUF3702; pfam12486 155864000764 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 155864000765 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 155864000766 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 155864000767 O-island #7; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864000768 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 155864000769 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 155864000770 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 155864000771 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 155864000772 type VI secretion-associated protein, VC_A0118 family; Region: VI_minor_1; TIGR03360 155864000773 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 155864000774 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 155864000775 Walker A motif; other site 155864000776 ATP binding site [chemical binding]; other site 155864000777 Walker B motif; other site 155864000778 arginine finger; other site 155864000779 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 155864000780 Walker A motif; other site 155864000781 ATP binding site [chemical binding]; other site 155864000782 Walker B motif; other site 155864000783 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 155864000784 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 155864000785 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 155864000786 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 155864000787 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3521 155864000788 Predicted component of the type VI protein secretion system, contains a FHA domain [Intracellular trafficking, secretion, and vesicular transport; Signal transduction mechanisms]; Region: COG3456 155864000789 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3520 155864000790 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 155864000791 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 155864000792 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 155864000793 O-island #7; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864000794 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 155864000795 Protein of unknown function (DUF877); Region: DUF877; pfam05943 155864000796 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 155864000797 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 155864000798 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 155864000799 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 155864000800 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 155864000801 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 155864000802 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 155864000803 PAAR motif; Region: PAAR_motif; cl15808 155864000804 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 155864000805 RHS Repeat; Region: RHS_repeat; cl11982 155864000806 RHS Repeat; Region: RHS_repeat; pfam05593 155864000807 RHS Repeat; Region: RHS_repeat; pfam05593 155864000808 RHS Repeat; Region: RHS_repeat; cl11982 155864000809 RHS Repeat; Region: RHS_repeat; cl11982 155864000810 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 155864000811 RHS Repeat; Region: RHS_repeat; pfam05593 155864000812 RHS Repeat; Region: RHS_repeat; pfam05593 155864000813 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 155864000814 RHS protein; Region: RHS; pfam03527 155864000815 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 155864000816 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 155864000817 O-island #7; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864000818 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 155864000819 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 155864000820 Transposase [DNA replication, recombination, and repair]; Region: COG5433 155864000821 Transposase [DNA replication, recombination, and repair]; Region: COG5433 155864000822 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 155864000823 Erythromycin esterase; Region: Erythro_esteras; cl17110 155864000824 RHS protein; Region: RHS; pfam03527 155864000825 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 155864000826 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 155864000827 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 155864000828 Transposase [DNA replication, recombination, and repair]; Region: COG5433 155864000829 Transposase [DNA replication, recombination, and repair]; Region: COG5433 155864000830 C-N hydrolase family amidase; Provisional; Region: PRK10438 155864000831 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 155864000832 putative active site [active] 155864000833 catalytic triad [active] 155864000834 dimer interface [polypeptide binding]; other site 155864000835 multimer interface [polypeptide binding]; other site 155864000836 C-lysozyme inhibitor; Provisional; Region: PRK09993 155864000837 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 155864000838 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 155864000839 active site 155864000840 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 155864000841 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 155864000842 dimer interface [polypeptide binding]; other site 155864000843 active site 155864000844 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 155864000845 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 155864000846 putative active site [active] 155864000847 putative dimer interface [polypeptide binding]; other site 155864000848 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 155864000849 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 155864000850 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041 155864000851 RelB antitoxin; Region: RelB; cl01171 155864000852 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 155864000853 NlpC/P60 family; Region: NLPC_P60; pfam00877 155864000854 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 155864000855 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298 155864000856 FHIPEP family; Region: FHIPEP; pfam00771 155864000857 hypothetical protein; Validated; Region: PRK06778 155864000858 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 155864000859 ligand binding site [chemical binding]; other site 155864000860 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 155864000861 active site 155864000862 DNA polymerase IV; Validated; Region: PRK02406 155864000863 DNA binding site [nucleotide binding] 155864000864 putative antitoxin of the YafO-YafN toxin-antitoxin system; Provisional; Region: PRK09778 155864000865 putative toxin YafO; Provisional; Region: PRK09885 155864000866 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 155864000867 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 155864000868 Coenzyme A binding pocket [chemical binding]; other site 155864000869 Uncharacterized protein family UPF0027; Region: UPF0027; cl17455 155864000870 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 155864000871 peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179 155864000872 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 155864000873 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 155864000874 metal binding site [ion binding]; metal-binding site 155864000875 dimer interface [polypeptide binding]; other site 155864000876 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 155864000877 active site 155864000878 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 155864000879 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 155864000880 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 155864000881 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 155864000882 trimer interface [polypeptide binding]; other site 155864000883 eyelet of channel; other site 155864000884 gamma-glutamyl kinase; Provisional; Region: PRK05429 155864000885 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 155864000886 nucleotide binding site [chemical binding]; other site 155864000887 homotetrameric interface [polypeptide binding]; other site 155864000888 putative phosphate binding site [ion binding]; other site 155864000889 putative allosteric binding site; other site 155864000890 PUA domain; Region: PUA; pfam01472 155864000891 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 155864000892 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 155864000893 putative catalytic cysteine [active] 155864000894 Cryptic prophage CP-933H; includes one copy of the 47bp direct repeat that flanks the prophage; O-island #8; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864000895 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 155864000896 P22-like integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial and phage integrases, including those similar to phage P22-like integrases, DLP12 and APSE-1; Region: INT_P22_C; cd01192 155864000897 Int/Topo IB signature motif; other site 155864000898 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 155864000899 non-specific DNA binding site [nucleotide binding]; other site 155864000900 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 155864000901 salt bridge; other site 155864000902 sequence-specific DNA binding site [nucleotide binding]; other site 155864000903 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 155864000904 Catalytic site [active] 155864000905 O-island #8; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864000906 Cryptic prophage CP-933H; includes one copy of the 47bp direct repeat that flanks the prophage 155864000907 Bacteriophage CII protein; Region: Phage_CII; pfam05269 155864000908 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 155864000909 Replication protein P; Region: Phage_lambda_P; pfam06992 155864000910 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 155864000911 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 155864000912 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 155864000913 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 155864000914 catalytic residues [active] 155864000915 catalytic nucleophile [active] 155864000916 Presynaptic Site I dimer interface [polypeptide binding]; other site 155864000917 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 155864000918 Synaptic Flat tetramer interface [polypeptide binding]; other site 155864000919 Synaptic Site I dimer interface [polypeptide binding]; other site 155864000920 DNA binding site [nucleotide binding] 155864000921 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 155864000922 DNA-binding interface [nucleotide binding]; DNA binding site 155864000923 GIY-YIG domain of uncharacterized proteins from bacteria and their eukaryotic homologs; Region: GIY-YIG_COG3680; cd10440 155864000924 GIY-YIG motif/motif A; other site 155864000925 putative active site [active] 155864000926 putative metal binding site [ion binding]; other site 155864000927 transcriptional regulator YdeO; Provisional; Region: PRK09940 155864000928 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 155864000929 Integrase core domain; Region: rve; pfam00665 155864000930 Integrase core domain; Region: rve_3; pfam13683 155864000931 Cryptic prophage CP-933I; includes one copy of the 16bp direct repeat that flanks the CP-933H/CP-933I complex 155864000932 integrase; Provisional; Region: PRK09692 155864000933 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 155864000934 active site 155864000935 Int/Topo IB signature motif; other site 155864000936 Restriction endonuclease; Region: Mrr_cat; pfam04471 155864000937 Cryptic prophage CP-933I; includes one copy of the 16bp direct repeat that flanks the CP-933H/CP-933I complex; O-island #8; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864000938 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 155864000939 Phage polarity suppression protein (Psu); Region: Psu; pfam07455 155864000940 Phage polarity suppression protein (Psu); Region: Psu; pfam07455 155864000941 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 155864000942 Ash protein family; Region: Phage_ASH; pfam10554 155864000943 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 155864000944 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 155864000945 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 155864000946 active site 155864000947 metal binding site [ion binding]; metal-binding site 155864000948 interdomain interaction site; other site 155864000949 D5 N terminal like; Region: D5_N; smart00885 155864000950 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 155864000951 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 155864000952 Transcriptional regulator [Transcription]; Region: LysR; COG0583 155864000953 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 155864000954 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 155864000955 putative effector binding pocket; other site 155864000956 putative dimerization interface [polypeptide binding]; other site 155864000957 O-island #9; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864000958 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 155864000959 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 155864000960 NAD(P) binding site [chemical binding]; other site 155864000961 active site 155864000962 O-island #9; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864000963 Transcriptional regulator [Transcription]; Region: LysR; COG0583 155864000964 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 155864000965 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 155864000966 putative effector binding pocket; other site 155864000967 putative dimerization interface [polypeptide binding]; other site 155864000968 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 155864000969 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 155864000970 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864000971 putative substrate translocation pore; other site 155864000972 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 155864000973 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 155864000974 XdhC Rossmann domain; Region: XdhC_C; pfam13478 155864000975 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 155864000976 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 155864000977 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 155864000978 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 155864000979 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 155864000980 aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433 155864000981 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 155864000982 catalytic loop [active] 155864000983 iron binding site [ion binding]; other site 155864000984 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 155864000985 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 155864000986 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 155864000987 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 155864000988 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 155864000989 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 155864000990 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 155864000991 DNA binding residues [nucleotide binding] 155864000992 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 155864000993 O-island #10; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864000994 Transposase; Region: HTH_Tnp_1; pfam01527 155864000995 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 155864000996 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 155864000997 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 155864000998 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 155864000999 homodimer interface [polypeptide binding]; other site 155864001000 putative GKAP docking site [polypeptide binding]; other site 155864001001 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 155864001002 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 155864001003 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 155864001004 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 155864001005 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 155864001006 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 155864001007 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 155864001008 putative active site [active] 155864001009 putative FMN binding site [chemical binding]; other site 155864001010 putative substrate binding site [chemical binding]; other site 155864001011 putative catalytic residue [active] 155864001012 O-island #11; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864001013 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 155864001014 Transcriptional regulator [Transcription]; Region: LysR; COG0583 155864001015 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 155864001016 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 155864001017 putative effector binding pocket; other site 155864001018 putative dimerization interface [polypeptide binding]; other site 155864001019 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 155864001020 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 155864001021 active site 155864001022 catalytic tetrad [active] 155864001023 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 155864001024 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 155864001025 Filamin/ABP280 repeat; Region: Filamin; pfam00630 155864001026 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 155864001027 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 155864001028 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 155864001029 O-island #12; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864001030 O-island #12; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864001031 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 155864001032 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 155864001033 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 155864001034 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 155864001035 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 155864001036 active site 155864001037 catalytic tetrad [active] 155864001038 O-island #13; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864001039 Predicted membrane protein [Function unknown]; Region: COG3059 155864001040 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 155864001041 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010 155864001042 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 155864001043 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 155864001044 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 155864001045 Cupin; Region: Cupin_6; pfam12852 155864001046 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 155864001047 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 155864001048 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 155864001049 Cysteine-rich domain; Region: CCG; pfam02754 155864001050 Cysteine-rich domain; Region: CCG; pfam02754 155864001051 iron-sulfur cluster-binding protein; Region: TIGR00273 155864001052 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 155864001053 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 155864001054 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 155864001055 Uncharacterized conserved protein [Function unknown]; Region: COG1556 155864001056 O-island #14; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864001057 O-island #14; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864001058 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 155864001059 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 155864001060 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 155864001061 DNA binding residues [nucleotide binding] 155864001062 dimerization interface [polypeptide binding]; other site 155864001063 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 155864001064 active site 155864001065 Int/Topo IB signature motif; other site 155864001066 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 155864001067 choline dehydrogenase; Validated; Region: PRK02106 155864001068 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 155864001069 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 155864001070 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 155864001071 tetrameric interface [polypeptide binding]; other site 155864001072 NAD binding site [chemical binding]; other site 155864001073 catalytic residues [active] 155864001074 transcriptional regulator BetI; Validated; Region: PRK00767 155864001075 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 155864001076 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 155864001077 choline transport protein BetT; Provisional; Region: PRK09928 155864001078 O-island #15; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864001079 O-island #15; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864001080 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 155864001081 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 155864001082 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 155864001083 Autotransporter beta-domain; Region: Autotransporter; pfam03797 155864001084 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 155864001085 DNA binding residues [nucleotide binding] 155864001086 dimerization interface [polypeptide binding]; other site 155864001087 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 155864001088 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 155864001089 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 155864001090 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 155864001091 dimerization interface [polypeptide binding]; other site 155864001092 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 155864001093 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 155864001094 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 155864001095 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 155864001096 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 155864001097 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 155864001098 CoA binding domain; Region: CoA_binding; pfam02629 155864001099 CoA-ligase; Region: Ligase_CoA; pfam00549 155864001100 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 155864001101 O-island #16; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864001102 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 155864001103 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 155864001104 putative substrate binding site [chemical binding]; other site 155864001105 nucleotide binding site [chemical binding]; other site 155864001106 nucleotide binding site [chemical binding]; other site 155864001107 homodimer interface [polypeptide binding]; other site 155864001108 putative deaminase; Validated; Region: PRK06846 155864001109 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 155864001110 active site 155864001111 O-island #17; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864001112 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 155864001113 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 155864001114 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 155864001115 ligand binding site [chemical binding]; other site 155864001116 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 155864001117 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 155864001118 Walker A/P-loop; other site 155864001119 ATP binding site [chemical binding]; other site 155864001120 Q-loop/lid; other site 155864001121 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 155864001122 Q-loop/lid; other site 155864001123 ABC transporter signature motif; other site 155864001124 Walker B; other site 155864001125 D-loop; other site 155864001126 H-loop/switch region; other site 155864001127 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 155864001128 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 155864001129 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 155864001130 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 155864001131 TM-ABC transporter signature motif; other site 155864001132 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 155864001133 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 155864001134 TM-ABC transporter signature motif; other site 155864001135 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 155864001136 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 155864001137 putative NAD(P) binding site [chemical binding]; other site 155864001138 putative substrate binding site [chemical binding]; other site 155864001139 catalytic Zn binding site [ion binding]; other site 155864001140 structural Zn binding site [ion binding]; other site 155864001141 dimer interface [polypeptide binding]; other site 155864001142 The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949 155864001143 hypothetical protein; Provisional; Region: PRK09929 155864001144 propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424 155864001145 Propionate catabolism activator; Region: PrpR_N; pfam06506 155864001146 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 155864001147 Walker A motif; other site 155864001148 ATP binding site [chemical binding]; other site 155864001149 Walker B motif; other site 155864001150 arginine finger; other site 155864001151 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 155864001152 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 155864001153 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 155864001154 tetramer interface [polypeptide binding]; other site 155864001155 active site 155864001156 Mg2+/Mn2+ binding site [ion binding]; other site 155864001157 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 155864001158 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 155864001159 dimer interface [polypeptide binding]; other site 155864001160 active site 155864001161 citrylCoA binding site [chemical binding]; other site 155864001162 oxalacetate/citrate binding site [chemical binding]; other site 155864001163 coenzyme A binding site [chemical binding]; other site 155864001164 catalytic triad [active] 155864001165 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 155864001166 2-methylcitrate dehydratase; Region: prpD; TIGR02330 155864001167 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 155864001168 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 155864001169 acyl-activating enzyme (AAE) consensus motif; other site 155864001170 putative AMP binding site [chemical binding]; other site 155864001171 putative active site [active] 155864001172 putative CoA binding site [chemical binding]; other site 155864001173 O-island #18; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864001174 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 155864001175 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 155864001176 Na binding site [ion binding]; other site 155864001177 putative substrate binding site [chemical binding]; other site 155864001178 cytosine deaminase; Provisional; Region: PRK09230 155864001179 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 155864001180 active site 155864001181 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 155864001182 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 155864001183 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425 155864001184 dimerization interface [polypeptide binding]; other site 155864001185 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 155864001186 active site clefts [active] 155864001187 zinc binding site [ion binding]; other site 155864001188 dimer interface [polypeptide binding]; other site 155864001189 Cyanate lyase [Inorganic ion transport and metabolism]; Region: CynS; COG1513 155864001190 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 155864001191 oligomer interface [polypeptide binding]; other site 155864001192 active site 155864001193 putative cyanate transporter; Provisional; Region: cynX; PRK09705 155864001194 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864001195 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 155864001196 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 155864001197 active site 155864001198 substrate binding site [chemical binding]; other site 155864001199 trimer interface [polypeptide binding]; other site 155864001200 CoA binding site [chemical binding]; other site 155864001201 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 155864001202 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864001203 putative substrate translocation pore; other site 155864001204 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 155864001205 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 155864001206 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 155864001207 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 155864001208 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 155864001209 lac repressor; Reviewed; Region: lacI; PRK09526 155864001210 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 155864001211 DNA binding site [nucleotide binding] 155864001212 domain linker motif; other site 155864001213 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 155864001214 ligand binding site [chemical binding]; other site 155864001215 dimerization interface (open form) [polypeptide binding]; other site 155864001216 dimerization interface (closed form) [polypeptide binding]; other site 155864001217 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 155864001218 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 155864001219 conserved cys residue [active] 155864001220 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 155864001221 O-island #19; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864001222 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 155864001223 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 155864001224 DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834 155864001225 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 155864001226 Bacterial transcriptional regulator; Region: IclR; pfam01614 155864001227 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 155864001228 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 155864001229 Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB), which catalyzes the oxidization and subsequent ring-opening of 2,3-dihydroxyphenylpropionate; Region: MhpB_like; cd07365 155864001230 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 155864001231 putative active site [active] 155864001232 Fe(II) binding site [ion binding]; other site 155864001233 putative dimer interface [polypeptide binding]; other site 155864001234 putative tetramer interface [polypeptide binding]; other site 155864001235 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 155864001236 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 155864001237 nucleophilic elbow; other site 155864001238 catalytic triad; other site 155864001239 2-keto-4-pentenoate hydratase; Provisional; Region: mhpD; PRK11342 155864001240 acetaldehyde dehydrogenase; Validated; Region: PRK08300 155864001241 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 155864001242 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 155864001243 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 155864001244 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 155864001245 active site 155864001246 catalytic residues [active] 155864001247 metal binding site [ion binding]; metal-binding site 155864001248 DmpG-like communication domain; Region: DmpG_comm; pfam07836 155864001249 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 155864001250 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864001251 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864001252 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 155864001253 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 155864001254 S-formylglutathione hydrolase; Region: PLN02442 155864001255 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 155864001256 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 155864001257 substrate binding site [chemical binding]; other site 155864001258 catalytic Zn binding site [ion binding]; other site 155864001259 NAD binding site [chemical binding]; other site 155864001260 structural Zn binding site [ion binding]; other site 155864001261 dimer interface [polypeptide binding]; other site 155864001262 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 155864001263 putative metal binding site [ion binding]; other site 155864001264 putative homodimer interface [polypeptide binding]; other site 155864001265 putative homotetramer interface [polypeptide binding]; other site 155864001266 putative homodimer-homodimer interface [polypeptide binding]; other site 155864001267 putative allosteric switch controlling residues; other site 155864001268 O-island #20; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864001269 ferric transporter ATP-binding subunit; Provisional; Region: fbpC; PRK11432 155864001270 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 155864001271 Walker A/P-loop; other site 155864001272 ATP binding site [chemical binding]; other site 155864001273 Q-loop/lid; other site 155864001274 ABC transporter signature motif; other site 155864001275 Walker B; other site 155864001276 D-loop; other site 155864001277 H-loop/switch region; other site 155864001278 TOBE domain; Region: TOBE_2; pfam08402 155864001279 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 155864001280 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 155864001281 dimer interface [polypeptide binding]; other site 155864001282 conserved gate region; other site 155864001283 putative PBP binding loops; other site 155864001284 ABC-ATPase subunit interface; other site 155864001285 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 155864001286 dimer interface [polypeptide binding]; other site 155864001287 conserved gate region; other site 155864001288 putative PBP binding loops; other site 155864001289 ABC-ATPase subunit interface; other site 155864001290 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 155864001291 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 155864001292 regulatory protein UhpC; Provisional; Region: PRK11663 155864001293 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864001294 putative substrate translocation pore; other site 155864001295 O-island #20; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864001296 Signal transduction histidine kinase, glucose-6-phosphate specific [Signal transduction mechanisms]; Region: UhpB; COG3851 155864001297 MASE1; Region: MASE1; pfam05231 155864001298 Histidine kinase; Region: HisKA_3; pfam07730 155864001299 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 155864001300 ATP binding site [chemical binding]; other site 155864001301 Mg2+ binding site [ion binding]; other site 155864001302 G-X-G motif; other site 155864001303 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 155864001304 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 155864001305 active site 155864001306 phosphorylation site [posttranslational modification] 155864001307 intermolecular recognition site; other site 155864001308 dimerization interface [polypeptide binding]; other site 155864001309 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 155864001310 DNA binding residues [nucleotide binding] 155864001311 dimerization interface [polypeptide binding]; other site 155864001312 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 155864001313 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 155864001314 substrate binding pocket [chemical binding]; other site 155864001315 membrane-bound complex binding site; other site 155864001316 hinge residues; other site 155864001317 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 155864001318 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 155864001319 Walker A/P-loop; other site 155864001320 ATP binding site [chemical binding]; other site 155864001321 Q-loop/lid; other site 155864001322 ABC transporter signature motif; other site 155864001323 Walker B; other site 155864001324 D-loop; other site 155864001325 H-loop/switch region; other site 155864001326 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 155864001327 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 155864001328 dimer interface [polypeptide binding]; other site 155864001329 conserved gate region; other site 155864001330 putative PBP binding loops; other site 155864001331 ABC-ATPase subunit interface; other site 155864001332 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 155864001333 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 155864001334 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 155864001335 dimer interface [polypeptide binding]; other site 155864001336 active site 155864001337 Schiff base residues; other site 155864001338 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 155864001339 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 155864001340 Autotransporter beta-domain; Region: Autotransporter; pfam03797 155864001341 O-island #21; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864001342 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 155864001343 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 155864001344 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 155864001345 microcin B17 transporter; Reviewed; Region: PRK11098 155864001346 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 155864001347 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 155864001348 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 155864001349 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 155864001350 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 155864001351 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 155864001352 anti-RssB factor; Provisional; Region: PRK10244 155864001353 alkaline phosphatase; Provisional; Region: PRK10518 155864001354 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 155864001355 dimer interface [polypeptide binding]; other site 155864001356 active site 155864001357 hypothetical protein; Provisional; Region: PRK11505 155864001358 psiF repeat; Region: PsiF_repeat; pfam07769 155864001359 psiF repeat; Region: PsiF_repeat; pfam07769 155864001360 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 155864001361 MASE2 domain; Region: MASE2; pfam05230 155864001362 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 155864001363 metal binding site [ion binding]; metal-binding site 155864001364 active site 155864001365 I-site; other site 155864001366 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 155864001367 pyrroline-5-carboxylate reductase; Region: PLN02688 155864001368 hypothetical protein; Validated; Region: PRK00124 155864001369 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 155864001370 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 155864001371 ADP binding site [chemical binding]; other site 155864001372 magnesium binding site [ion binding]; other site 155864001373 putative shikimate binding site; other site 155864001374 hypothetical protein; Provisional; Region: PRK10380 155864001375 hypothetical protein; Provisional; Region: PRK10481 155864001376 hypothetical protein; Provisional; Region: PRK10579 155864001377 O-island #22; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864001378 Protein of unknown function (DUF2773); Region: DUF2773; pfam10971 155864001379 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 155864001380 O-island #23; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864001381 DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974 155864001382 fructokinase; Reviewed; Region: PRK09557 155864001383 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 155864001384 nucleotide binding site [chemical binding]; other site 155864001385 MFS transport protein AraJ; Provisional; Region: PRK10091 155864001386 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864001387 putative substrate translocation pore; other site 155864001388 exonuclease subunit SbcC; Provisional; Region: PRK10246 155864001389 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 155864001390 Walker A/P-loop; other site 155864001391 ATP binding site [chemical binding]; other site 155864001392 Q-loop/lid; other site 155864001393 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 155864001394 ABC transporter signature motif; other site 155864001395 Walker B; other site 155864001396 D-loop; other site 155864001397 H-loop/switch region; other site 155864001398 exonuclease subunit SbcD; Provisional; Region: PRK10966 155864001399 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 155864001400 active site 155864001401 metal binding site [ion binding]; metal-binding site 155864001402 DNA binding site [nucleotide binding] 155864001403 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 155864001404 transcriptional regulator PhoB; Provisional; Region: PRK10161 155864001405 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 155864001406 active site 155864001407 phosphorylation site [posttranslational modification] 155864001408 intermolecular recognition site; other site 155864001409 dimerization interface [polypeptide binding]; other site 155864001410 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 155864001411 DNA binding site [nucleotide binding] 155864001412 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 155864001413 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 155864001414 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 155864001415 putative active site [active] 155864001416 heme pocket [chemical binding]; other site 155864001417 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 155864001418 dimer interface [polypeptide binding]; other site 155864001419 phosphorylation site [posttranslational modification] 155864001420 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 155864001421 ATP binding site [chemical binding]; other site 155864001422 Mg2+ binding site [ion binding]; other site 155864001423 G-X-G motif; other site 155864001424 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 155864001425 putative proline-specific permease; Provisional; Region: proY; PRK10580 155864001426 Spore germination protein; Region: Spore_permease; cl17796 155864001427 maltodextrin glucosidase; Provisional; Region: PRK10785 155864001428 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 155864001429 homodimer interface [polypeptide binding]; other site 155864001430 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 155864001431 active site 155864001432 homodimer interface [polypeptide binding]; other site 155864001433 catalytic site [active] 155864001434 O-island #24; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864001435 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 155864001436 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 155864001437 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 155864001438 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 155864001439 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 155864001440 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 155864001441 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 155864001442 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 155864001443 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 155864001444 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 155864001445 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 155864001446 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 155864001447 Protein export membrane protein; Region: SecD_SecF; pfam02355 155864001448 O-island #25; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864001449 Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693 155864001450 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 155864001451 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 155864001452 active site 155864001453 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 155864001454 hypothetical protein; Provisional; Region: PRK11530 155864001455 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 155864001456 ATP cone domain; Region: ATP-cone; pfam03477 155864001457 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 155864001458 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 155864001459 catalytic motif [active] 155864001460 Zn binding site [ion binding]; other site 155864001461 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 155864001462 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 155864001463 homopentamer interface [polypeptide binding]; other site 155864001464 active site 155864001465 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 155864001466 putative RNA binding site [nucleotide binding]; other site 155864001467 thiamine monophosphate kinase; Provisional; Region: PRK05731 155864001468 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 155864001469 ATP binding site [chemical binding]; other site 155864001470 dimerization interface [polypeptide binding]; other site 155864001471 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 155864001472 tetramer interfaces [polypeptide binding]; other site 155864001473 binuclear metal-binding site [ion binding]; other site 155864001474 O-island #26; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864001475 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 155864001476 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 155864001477 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 155864001478 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 155864001479 active site 155864001480 catalytic tetrad [active] 155864001481 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 155864001482 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 155864001483 TPP-binding site; other site 155864001484 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 155864001485 PYR/PP interface [polypeptide binding]; other site 155864001486 dimer interface [polypeptide binding]; other site 155864001487 TPP binding site [chemical binding]; other site 155864001488 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 155864001489 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 155864001490 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 155864001491 substrate binding pocket [chemical binding]; other site 155864001492 chain length determination region; other site 155864001493 substrate-Mg2+ binding site; other site 155864001494 catalytic residues [active] 155864001495 aspartate-rich region 1; other site 155864001496 active site lid residues [active] 155864001497 aspartate-rich region 2; other site 155864001498 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 155864001499 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 155864001500 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 155864001501 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 155864001502 Ligand Binding Site [chemical binding]; other site 155864001503 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 155864001504 active site residue [active] 155864001505 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 155864001506 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 155864001507 conserved cys residue [active] 155864001508 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 155864001509 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 155864001510 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 155864001511 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 155864001512 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 155864001513 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864001514 Major Facilitator Superfamily; Region: MFS_1; pfam07690 155864001515 putative substrate translocation pore; other site 155864001516 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 155864001517 UbiA prenyltransferase family; Region: UbiA; pfam01040 155864001518 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 155864001519 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 155864001520 Subunit I/III interface [polypeptide binding]; other site 155864001521 Subunit III/IV interface [polypeptide binding]; other site 155864001522 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 155864001523 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 155864001524 D-pathway; other site 155864001525 Putative ubiquinol binding site [chemical binding]; other site 155864001526 Low-spin heme (heme b) binding site [chemical binding]; other site 155864001527 Putative water exit pathway; other site 155864001528 Binuclear center (heme o3/CuB) [ion binding]; other site 155864001529 K-pathway; other site 155864001530 Putative proton exit pathway; other site 155864001531 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 155864001532 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 155864001533 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 155864001534 muropeptide transporter; Reviewed; Region: ampG; PRK11902 155864001535 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864001536 putative substrate translocation pore; other site 155864001537 hypothetical protein; Provisional; Region: PRK11627 155864001538 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 155864001539 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 155864001540 transcriptional regulator BolA; Provisional; Region: PRK11628 155864001541 trigger factor; Provisional; Region: tig; PRK01490 155864001542 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 155864001543 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 155864001544 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 155864001545 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 155864001546 oligomer interface [polypeptide binding]; other site 155864001547 active site residues [active] 155864001548 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 155864001549 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 155864001550 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 155864001551 Walker A motif; other site 155864001552 ATP binding site [chemical binding]; other site 155864001553 Walker B motif; other site 155864001554 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 155864001555 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 155864001556 Found in ATP-dependent protease La (LON); Region: LON; smart00464 155864001557 Found in ATP-dependent protease La (LON); Region: LON; smart00464 155864001558 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 155864001559 Walker A motif; other site 155864001560 ATP binding site [chemical binding]; other site 155864001561 Walker B motif; other site 155864001562 arginine finger; other site 155864001563 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 155864001564 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 155864001565 IHF dimer interface [polypeptide binding]; other site 155864001566 IHF - DNA interface [nucleotide binding]; other site 155864001567 periplasmic folding chaperone; Provisional; Region: PRK10788 155864001568 SurA N-terminal domain; Region: SurA_N_3; cl07813 155864001569 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 155864001570 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 155864001571 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 155864001572 active site 155864001573 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 155864001574 Ligand Binding Site [chemical binding]; other site 155864001575 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 155864001576 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 155864001577 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 155864001578 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 155864001579 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 155864001580 active site 155864001581 motif I; other site 155864001582 motif II; other site 155864001583 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 155864001584 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 155864001585 putative DNA binding site [nucleotide binding]; other site 155864001586 putative Zn2+ binding site [ion binding]; other site 155864001587 AsnC family; Region: AsnC_trans_reg; pfam01037 155864001588 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 155864001589 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 155864001590 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 155864001591 Walker A/P-loop; other site 155864001592 ATP binding site [chemical binding]; other site 155864001593 Q-loop/lid; other site 155864001594 ABC transporter signature motif; other site 155864001595 Walker B; other site 155864001596 D-loop; other site 155864001597 H-loop/switch region; other site 155864001598 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 155864001599 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 155864001600 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 155864001601 Walker A/P-loop; other site 155864001602 ATP binding site [chemical binding]; other site 155864001603 Q-loop/lid; other site 155864001604 ABC transporter signature motif; other site 155864001605 Walker B; other site 155864001606 D-loop; other site 155864001607 H-loop/switch region; other site 155864001608 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 155864001609 Nitrogen regulatory protein P-II; Region: P-II; smart00938 155864001610 ammonium transporter; Provisional; Region: PRK10666 155864001611 acyl-CoA thioesterase II; Provisional; Region: PRK10526 155864001612 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 155864001613 active site 155864001614 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 155864001615 catalytic triad [active] 155864001616 dimer interface [polypeptide binding]; other site 155864001617 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 155864001618 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 155864001619 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 155864001620 DNA binding site [nucleotide binding] 155864001621 active site 155864001622 Uncharacterized conserved protein [Function unknown]; Region: COG5507 155864001623 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 155864001624 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 155864001625 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 155864001626 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 155864001627 maltose O-acetyltransferase; Provisional; Region: PRK10092 155864001628 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 155864001629 active site 155864001630 substrate binding site [chemical binding]; other site 155864001631 trimer interface [polypeptide binding]; other site 155864001632 CoA binding site [chemical binding]; other site 155864001633 gene expression modulator; Provisional; Region: PRK10945 155864001634 Biofilm formation regulator YbaJ; Region: YbaJ; pfam10757 155864001635 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 155864001636 Protein export membrane protein; Region: SecD_SecF; cl14618 155864001637 Protein export membrane protein; Region: SecD_SecF; cl14618 155864001638 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 155864001639 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 155864001640 HlyD family secretion protein; Region: HlyD_3; pfam13437 155864001641 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 155864001642 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 155864001643 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 155864001644 hypothetical protein; Provisional; Region: PRK11281 155864001645 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 155864001646 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 155864001647 Mechanosensitive ion channel; Region: MS_channel; pfam00924 155864001648 hypothetical protein; Provisional; Region: PRK11038 155864001649 primosomal replication protein N''; Provisional; Region: PRK10093 155864001650 hypothetical protein; Provisional; Region: PRK10527 155864001651 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 155864001652 active site 155864001653 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 155864001654 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 155864001655 Walker A motif; other site 155864001656 ATP binding site [chemical binding]; other site 155864001657 Walker B motif; other site 155864001658 DNA polymerase III subunit delta'; Validated; Region: PRK08485 155864001659 arginine finger; other site 155864001660 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 155864001661 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 155864001662 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 155864001663 hypothetical protein; Validated; Region: PRK00153 155864001664 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecR; COG0353 155864001665 RecR protein; Region: RecR; pfam02132 155864001666 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 155864001667 putative active site [active] 155864001668 putative metal-binding site [ion binding]; other site 155864001669 tetramer interface [polypeptide binding]; other site 155864001670 heat shock protein 90; Provisional; Region: PRK05218 155864001671 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 155864001672 ATP binding site [chemical binding]; other site 155864001673 Mg2+ binding site [ion binding]; other site 155864001674 G-X-G motif; other site 155864001675 adenylate kinase; Reviewed; Region: adk; PRK00279 155864001676 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 155864001677 AMP-binding site [chemical binding]; other site 155864001678 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 155864001679 O-island #27; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864001680 ferrochelatase; Region: hemH; TIGR00109 155864001681 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 155864001682 C-terminal domain interface [polypeptide binding]; other site 155864001683 active site 155864001684 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 155864001685 active site 155864001686 N-terminal domain interface [polypeptide binding]; other site 155864001687 acetyl esterase; Provisional; Region: PRK10162 155864001688 inosine/guanosine kinase; Provisional; Region: PRK15074 155864001689 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 155864001690 putative cation:proton antiport protein; Provisional; Region: PRK10669 155864001691 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 155864001692 TrkA-N domain; Region: TrkA_N; pfam02254 155864001693 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864001694 Major Facilitator Superfamily; Region: MFS_1; pfam07690 155864001695 putative substrate translocation pore; other site 155864001696 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 155864001697 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 155864001698 active site 155864001699 metal binding site [ion binding]; metal-binding site 155864001700 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 155864001701 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 155864001702 putative deacylase active site [active] 155864001703 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 155864001704 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 155864001705 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 155864001706 non-specific DNA binding site [nucleotide binding]; other site 155864001707 salt bridge; other site 155864001708 sequence-specific DNA binding site [nucleotide binding]; other site 155864001709 copper exporting ATPase; Provisional; Region: copA; PRK10671 155864001710 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 155864001711 metal-binding site [ion binding] 155864001712 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 155864001713 metal-binding site [ion binding] 155864001714 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 155864001715 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 155864001716 motif II; other site 155864001717 glutaminase; Reviewed; Region: PRK12356 155864001718 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 155864001719 amino acid transporter; Region: 2A0306; TIGR00909 155864001720 O-island #28; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864001721 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 155864001722 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 155864001723 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 155864001724 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 155864001725 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 155864001726 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 155864001727 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 155864001728 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 155864001729 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 155864001730 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 155864001731 O-island #28; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864001732 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 155864001733 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 155864001734 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 155864001735 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 155864001736 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 155864001737 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 155864001738 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 155864001739 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 155864001740 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 155864001741 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 155864001742 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 155864001743 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 155864001744 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 155864001745 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 155864001746 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 155864001747 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 155864001748 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 155864001749 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 155864001750 Family description; Region: VCBS; pfam13517 155864001751 Family description; Region: VCBS; pfam13517 155864001752 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 155864001753 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 155864001754 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 155864001755 putative active site [active] 155864001756 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 155864001757 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 155864001758 Walker A/P-loop; other site 155864001759 ATP binding site [chemical binding]; other site 155864001760 Q-loop/lid; other site 155864001761 ABC transporter signature motif; other site 155864001762 Walker B; other site 155864001763 D-loop; other site 155864001764 H-loop/switch region; other site 155864001765 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 155864001766 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 155864001767 HlyD family secretion protein; Region: HlyD_3; pfam13437 155864001768 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 155864001769 O-island #29; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864001770 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 155864001771 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 155864001772 YadA-like C-terminal region; Region: YadA; pfam03895 155864001773 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 155864001774 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 155864001775 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 155864001776 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 155864001777 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 155864001778 Walker A/P-loop; other site 155864001779 ATP binding site [chemical binding]; other site 155864001780 Q-loop/lid; other site 155864001781 ABC transporter signature motif; other site 155864001782 Walker B; other site 155864001783 D-loop; other site 155864001784 H-loop/switch region; other site 155864001785 Uncharacterized protein family (UPF0014); Region: UPF0014; pfam03649 155864001786 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 155864001787 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 155864001788 oxidoreductase; Provisional; Region: PRK08017 155864001789 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 155864001790 NADP binding site [chemical binding]; other site 155864001791 active site 155864001792 steroid binding site; other site 155864001793 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 155864001794 active site 155864001795 catalytic triad [active] 155864001796 oxyanion hole [active] 155864001797 switch loop; other site 155864001798 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 155864001799 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 155864001800 Walker A/P-loop; other site 155864001801 ATP binding site [chemical binding]; other site 155864001802 Q-loop/lid; other site 155864001803 ABC transporter signature motif; other site 155864001804 Walker B; other site 155864001805 D-loop; other site 155864001806 H-loop/switch region; other site 155864001807 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 155864001808 FtsX-like permease family; Region: FtsX; pfam02687 155864001809 FtsX-like permease family; Region: FtsX; pfam02687 155864001810 PAAR motif; Region: PAAR_motif; cl15808 155864001811 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 155864001812 RHS Repeat; Region: RHS_repeat; pfam05593 155864001813 RHS Repeat; Region: RHS_repeat; pfam05593 155864001814 RHS Repeat; Region: RHS_repeat; cl11982 155864001815 RHS Repeat; Region: RHS_repeat; pfam05593 155864001816 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 155864001817 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 155864001818 RHS Repeat; Region: RHS_repeat; pfam05593 155864001819 RHS protein; Region: RHS; pfam03527 155864001820 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 155864001821 hypothetical protein; Provisional; Region: PRK14710 155864001822 Winged helix-turn helix; Region: HTH_29; pfam13551 155864001823 Helix-turn-helix domain; Region: HTH_28; pfam13518 155864001824 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 155864001825 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 155864001826 active site residue [active] 155864001827 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 155864001828 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 155864001829 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 155864001830 dimerization interface [polypeptide binding]; other site 155864001831 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 155864001832 ureidoglycolate hydrolase; Provisional; Region: PRK03606 155864001833 DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163 155864001834 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 155864001835 Bacterial transcriptional regulator; Region: IclR; pfam01614 155864001836 glyoxylate carboligase; Provisional; Region: PRK11269 155864001837 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 155864001838 PYR/PP interface [polypeptide binding]; other site 155864001839 dimer interface [polypeptide binding]; other site 155864001840 TPP binding site [chemical binding]; other site 155864001841 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 155864001842 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 155864001843 TPP-binding site [chemical binding]; other site 155864001844 hydroxypyruvate isomerase; Provisional; Region: PRK09997 155864001845 tartronate semialdehyde reductase; Provisional; Region: PRK15059 155864001846 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 155864001847 nucleobase-cation-symport-1 (NCS1) transporters; solute-binding domain; Region: SLC-NCS1sbd; cd10323 155864001848 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 155864001849 Na binding site [ion binding]; other site 155864001850 substrate binding site [chemical binding]; other site 155864001851 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 155864001852 active site 155864001853 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 155864001854 putative uracil/xanthine transporter; Provisional; Region: PRK11412 155864001855 glycerate kinase II; Provisional; Region: PRK09932 155864001856 Uncharacterized protein, possibly involved in glyoxylate utilization [General function prediction only]; Region: GlxB; COG3257 155864001857 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 155864001858 Cupin domain; Region: Cupin_2; cl17218 155864001859 allantoate amidohydrolase; Region: AllC; TIGR03176 155864001860 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 155864001861 active site 155864001862 metal binding site [ion binding]; metal-binding site 155864001863 dimer interface [polypeptide binding]; other site 155864001864 ureidoglycolate dehydrogenase; Provisional; Region: PRK15025 155864001865 membrane protein FdrA; Validated; Region: PRK06091 155864001866 CoA binding domain; Region: CoA_binding; pfam02629 155864001867 CoA-ligase; Region: Ligase_CoA; pfam00549 155864001868 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 155864001869 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 155864001870 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 155864001871 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 155864001872 putative substrate binding site [chemical binding]; other site 155864001873 nucleotide binding site [chemical binding]; other site 155864001874 nucleotide binding site [chemical binding]; other site 155864001875 homodimer interface [polypeptide binding]; other site 155864001876 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 155864001877 ATP-grasp domain; Region: ATP-grasp; pfam02222 155864001878 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 155864001879 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 155864001880 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 155864001881 putative active site [active] 155864001882 putative metal binding site [ion binding]; other site 155864001883 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 155864001884 substrate binding site [chemical binding]; other site 155864001885 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 155864001886 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 155864001887 active site 155864001888 HIGH motif; other site 155864001889 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 155864001890 KMSKS motif; other site 155864001891 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 155864001892 tRNA binding surface [nucleotide binding]; other site 155864001893 anticodon binding site; other site 155864001894 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 155864001895 ribosome-associated protein; Provisional; Region: PRK11507 155864001896 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 155864001897 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 155864001898 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 155864001899 homodimer interface [polypeptide binding]; other site 155864001900 NADP binding site [chemical binding]; other site 155864001901 substrate binding site [chemical binding]; other site 155864001902 type-1 fimbrial protein subunit A; Provisional; Region: PRK15194 155864001903 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 155864001904 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 155864001905 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 155864001906 outer membrane usher protein FimD; Provisional; Region: PRK15198 155864001907 PapC N-terminal domain; Region: PapC_N; pfam13954 155864001908 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 155864001909 PapC C-terminal domain; Region: PapC_C; pfam13953 155864001910 fimbrial-like adhesin; Provisional; Region: fimH; PRK15199 155864001911 fimbrial-like adhesin protein SfmF; Provisional; Region: PRK09934 155864001912 transcriptional regulator FimZ; Provisional; Region: PRK09935 155864001913 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 155864001914 active site 155864001915 phosphorylation site [posttranslational modification] 155864001916 intermolecular recognition site; other site 155864001917 dimerization interface [polypeptide binding]; other site 155864001918 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 155864001919 DNA binding residues [nucleotide binding] 155864001920 dimerization interface [polypeptide binding]; other site 155864001921 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 155864001922 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 155864001923 hypothetical protein; Provisional; Region: PRK09936 155864001924 bacteriophage N4 receptor, outer membrane subunit; Provisional; Region: PRK09782 155864001925 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 155864001926 TPR motif; other site 155864001927 binding surface 155864001928 Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283 155864001929 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 155864001930 active site 155864001931 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 155864001932 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 155864001933 O-island #30; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864001934 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 155864001935 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 155864001936 Transposase [DNA replication, recombination, and repair]; Region: COG5433 155864001937 Transposase [DNA replication, recombination, and repair]; Region: COG5433 155864001938 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 155864001939 RHS Repeat; Region: RHS_repeat; cl11982 155864001940 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 155864001941 O-island #30; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864001942 PAAR motif; Region: PAAR_motif; pfam05488 155864001943 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 155864001944 RHS Repeat; Region: RHS_repeat; pfam05593 155864001945 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 155864001946 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 155864001947 RHS Repeat; Region: RHS_repeat; cl11982 155864001948 RHS Repeat; Region: RHS_repeat; pfam05593 155864001949 RHS Repeat; Region: RHS_repeat; cl11982 155864001950 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 155864001951 RHS Repeat; Region: RHS_repeat; cl11982 155864001952 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 155864001953 Uncharacterized conserved protein [Function unknown]; Region: COG5435 155864001954 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 155864001955 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 155864001956 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 155864001957 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 155864001958 sensor kinase CusS; Provisional; Region: PRK09835 155864001959 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 155864001960 dimerization interface [polypeptide binding]; other site 155864001961 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 155864001962 dimer interface [polypeptide binding]; other site 155864001963 phosphorylation site [posttranslational modification] 155864001964 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 155864001965 ATP binding site [chemical binding]; other site 155864001966 Mg2+ binding site [ion binding]; other site 155864001967 G-X-G motif; other site 155864001968 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 155864001969 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 155864001970 active site 155864001971 phosphorylation site [posttranslational modification] 155864001972 intermolecular recognition site; other site 155864001973 dimerization interface [polypeptide binding]; other site 155864001974 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 155864001975 DNA binding site [nucleotide binding] 155864001976 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 155864001977 periplasmic copper-binding protein; Provisional; Region: PRK09838 155864001978 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 155864001979 HlyD family secretion protein; Region: HlyD_3; pfam13437 155864001980 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 155864001981 phenylalanine transporter; Provisional; Region: PRK10249 155864001982 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 155864001983 Mechanosensitive ion channel; Region: MS_channel; pfam00924 155864001984 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 155864001985 dimer interface [polypeptide binding]; other site 155864001986 FMN binding site [chemical binding]; other site 155864001987 hypothetical protein; Provisional; Region: PRK10250 155864001988 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 155864001989 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 155864001990 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 155864001991 Hok/gef family; Region: HOK_GEF; pfam01848 155864001992 O-island #31; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864001993 Hok/gef family; Region: HOK_GEF; pfam01848 155864001994 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 155864001995 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 155864001996 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 155864001997 outer membrane receptor FepA; Provisional; Region: PRK13524 155864001998 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 155864001999 N-terminal plug; other site 155864002000 ligand-binding site [chemical binding]; other site 155864002001 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 155864002002 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 155864002003 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 155864002004 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 155864002005 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 155864002006 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 155864002007 acyl-activating enzyme (AAE) consensus motif; other site 155864002008 AMP binding site [chemical binding]; other site 155864002009 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 155864002010 LPS O-antigen length regulator; Provisional; Region: PRK10381 155864002011 Chain length determinant protein; Region: Wzz; pfam02706 155864002012 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 155864002013 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 155864002014 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 155864002015 Walker A/P-loop; other site 155864002016 ATP binding site [chemical binding]; other site 155864002017 Q-loop/lid; other site 155864002018 ABC transporter signature motif; other site 155864002019 Walker B; other site 155864002020 D-loop; other site 155864002021 H-loop/switch region; other site 155864002022 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 155864002023 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 155864002024 ABC-ATPase subunit interface; other site 155864002025 dimer interface [polypeptide binding]; other site 155864002026 putative PBP binding regions; other site 155864002027 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 155864002028 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 155864002029 ABC-ATPase subunit interface; other site 155864002030 dimer interface [polypeptide binding]; other site 155864002031 putative PBP binding regions; other site 155864002032 enterobactin exporter EntS; Provisional; Region: PRK10489 155864002033 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864002034 putative substrate translocation pore; other site 155864002035 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 155864002036 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 155864002037 siderophore binding site; other site 155864002038 isochorismate synthase EntC; Provisional; Region: PRK15016 155864002039 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 155864002040 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 155864002041 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 155864002042 acyl-activating enzyme (AAE) consensus motif; other site 155864002043 active site 155864002044 AMP binding site [chemical binding]; other site 155864002045 substrate binding site [chemical binding]; other site 155864002046 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 155864002047 hydrophobic substrate binding pocket; other site 155864002048 Isochorismatase family; Region: Isochorismatase; pfam00857 155864002049 active site 155864002050 conserved cis-peptide bond; other site 155864002051 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 155864002052 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 155864002053 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 155864002054 putative NAD(P) binding site [chemical binding]; other site 155864002055 active site 155864002056 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 155864002057 CoenzymeA binding site [chemical binding]; other site 155864002058 subunit interaction site [polypeptide binding]; other site 155864002059 PHB binding site; other site 155864002060 carbon starvation protein A; Provisional; Region: PRK15015 155864002061 Carbon starvation protein CstA; Region: CstA; pfam02554 155864002062 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 155864002063 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 155864002064 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 155864002065 putative active site [active] 155864002066 metal binding site [ion binding]; metal-binding site 155864002067 methionine aminotransferase; Validated; Region: PRK09082 155864002068 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 155864002069 pyridoxal 5'-phosphate binding site [chemical binding]; other site 155864002070 homodimer interface [polypeptide binding]; other site 155864002071 catalytic residue [active] 155864002072 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 155864002073 ParB-like nuclease domain; Region: ParBc; pfam02195 155864002074 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 155864002075 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 155864002076 Active Sites [active] 155864002077 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 155864002078 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 155864002079 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 155864002080 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 155864002081 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 155864002082 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 155864002083 dimerization domain [polypeptide binding]; other site 155864002084 dimer interface [polypeptide binding]; other site 155864002085 catalytic residues [active] 155864002086 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 155864002087 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 155864002088 dimer interface [polypeptide binding]; other site 155864002089 decamer (pentamer of dimers) interface [polypeptide binding]; other site 155864002090 catalytic triad [active] 155864002091 peroxidatic and resolving cysteines [active] 155864002092 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 155864002093 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 155864002094 catalytic residue [active] 155864002095 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 155864002096 catalytic residues [active] 155864002097 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 155864002098 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 155864002099 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 155864002100 Ligand Binding Site [chemical binding]; other site 155864002101 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 155864002102 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 155864002103 NAD binding site [chemical binding]; other site 155864002104 catalytic Zn binding site [ion binding]; other site 155864002105 structural Zn binding site [ion binding]; other site 155864002106 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 155864002107 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 155864002108 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 155864002109 B1 nucleotide binding pocket [chemical binding]; other site 155864002110 B2 nucleotide binding pocket [chemical binding]; other site 155864002111 CAS motifs; other site 155864002112 active site 155864002113 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 155864002114 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 155864002115 transmembrane helices; other site 155864002116 triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096 155864002117 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 155864002118 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 155864002119 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 155864002120 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 155864002121 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 155864002122 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 155864002123 putative active site [active] 155864002124 (T/H)XGH motif; other site 155864002125 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 155864002126 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 155864002127 putative active site [active] 155864002128 heme pocket [chemical binding]; other site 155864002129 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 155864002130 ATP binding site [chemical binding]; other site 155864002131 Mg2+ binding site [ion binding]; other site 155864002132 G-X-G motif; other site 155864002133 two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046 155864002134 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 155864002135 active site 155864002136 phosphorylation site [posttranslational modification] 155864002137 intermolecular recognition site; other site 155864002138 dimerization interface [polypeptide binding]; other site 155864002139 Transcriptional regulator; Region: CitT; pfam12431 155864002140 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 155864002141 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 155864002142 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 155864002143 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 155864002144 DNA-binding site [nucleotide binding]; DNA binding site 155864002145 RNA-binding motif; other site 155864002146 chromosome condensation membrane protein; Provisional; Region: PRK14196 155864002147 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 155864002148 Predicted amidohydrolase [General function prediction only]; Region: COG0388 155864002149 active site 155864002150 catalytic triad [active] 155864002151 dimer interface [polypeptide binding]; other site 155864002152 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 155864002153 lipoyl synthase; Provisional; Region: PRK05481 155864002154 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 155864002155 FeS/SAM binding site; other site 155864002156 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 155864002157 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 155864002158 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 155864002159 substrate binding pocket [chemical binding]; other site 155864002160 dimerization interface [polypeptide binding]; other site 155864002161 lipoate-protein ligase B; Provisional; Region: PRK14342 155864002162 hypothetical protein; Provisional; Region: PRK04998 155864002163 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 155864002164 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 155864002165 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 155864002166 rare lipoprotein A; Provisional; Region: PRK10672 155864002167 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 155864002168 Sporulation related domain; Region: SPOR; pfam05036 155864002169 cell wall shape-determining protein; Provisional; Region: PRK10794 155864002170 penicillin-binding protein 2; Provisional; Region: PRK10795 155864002171 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 155864002172 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 155864002173 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 155864002174 Oligomerisation domain; Region: Oligomerisation; cl00519 155864002175 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 155864002176 catalytic core [active] 155864002177 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 155864002178 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 155864002179 active site 155864002180 (T/H)XGH motif; other site 155864002181 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 155864002182 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 155864002183 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 155864002184 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 155864002185 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 155864002186 HIGH motif; other site 155864002187 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 155864002188 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 155864002189 active site 155864002190 KMSKS motif; other site 155864002191 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 155864002192 tRNA binding surface [nucleotide binding]; other site 155864002193 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 155864002194 hypothetical protein; Provisional; Region: PRK11032 155864002195 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 155864002196 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 155864002197 Sel1-like repeats; Region: SEL1; smart00671 155864002198 Sel1-like repeats; Region: SEL1; smart00671 155864002199 Sel1-like repeats; Region: SEL1; smart00671 155864002200 Sel1-like repeats; Region: SEL1; smart00671 155864002201 Sel1-like repeats; Region: SEL1; smart00671 155864002202 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 155864002203 DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271 155864002204 HSP70 interaction site [polypeptide binding]; other site 155864002205 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 155864002206 Sel1-like repeats; Region: SEL1; smart00671 155864002207 Sel1-like repeats; Region: SEL1; smart00671 155864002208 Sel1-like repeats; Region: SEL1; smart00671 155864002209 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 155864002210 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 155864002211 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 155864002212 nucleotide binding site [chemical binding]; other site 155864002213 putative NEF/HSP70 interaction site [polypeptide binding]; other site 155864002214 SBD interface [polypeptide binding]; other site 155864002215 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 155864002216 active site 155864002217 tetramer interface [polypeptide binding]; other site 155864002218 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 155864002219 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 155864002220 Walker A/P-loop; other site 155864002221 ATP binding site [chemical binding]; other site 155864002222 Q-loop/lid; other site 155864002223 ABC transporter signature motif; other site 155864002224 Walker B; other site 155864002225 D-loop; other site 155864002226 H-loop/switch region; other site 155864002227 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 155864002228 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 155864002229 dimer interface [polypeptide binding]; other site 155864002230 conserved gate region; other site 155864002231 putative PBP binding loops; other site 155864002232 ABC-ATPase subunit interface; other site 155864002233 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 155864002234 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 155864002235 dimer interface [polypeptide binding]; other site 155864002236 conserved gate region; other site 155864002237 putative PBP binding loops; other site 155864002238 ABC-ATPase subunit interface; other site 155864002239 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 155864002240 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 155864002241 substrate binding pocket [chemical binding]; other site 155864002242 membrane-bound complex binding site; other site 155864002243 hinge residues; other site 155864002244 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 155864002245 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 155864002246 putative active site [active] 155864002247 catalytic triad [active] 155864002248 putative dimer interface [polypeptide binding]; other site 155864002249 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 155864002250 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 155864002251 Transporter associated domain; Region: CorC_HlyC; smart01091 155864002252 metal-binding heat shock protein; Provisional; Region: PRK00016 155864002253 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 155864002254 PhoH-like protein; Region: PhoH; pfam02562 155864002255 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 155864002256 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 155864002257 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 155864002258 FeS/SAM binding site; other site 155864002259 TRAM domain; Region: TRAM; pfam01938 155864002260 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 155864002261 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 155864002262 asparagine synthetase B; Provisional; Region: asnB; PRK09431 155864002263 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 155864002264 active site 155864002265 dimer interface [polypeptide binding]; other site 155864002266 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 155864002267 Ligand Binding Site [chemical binding]; other site 155864002268 Molecular Tunnel; other site 155864002269 UMP phosphatase; Provisional; Region: PRK10444 155864002270 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 155864002271 active site 155864002272 motif I; other site 155864002273 motif II; other site 155864002274 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 155864002275 MarR family; Region: MarR; pfam01047 155864002276 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 155864002277 ROK family; Region: ROK; pfam00480 155864002278 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 155864002279 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 155864002280 active site 155864002281 dimer interface [polypeptide binding]; other site 155864002282 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 155864002283 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 155864002284 active site 155864002285 trimer interface [polypeptide binding]; other site 155864002286 allosteric site; other site 155864002287 active site lid [active] 155864002288 hexamer (dimer of trimers) interface [polypeptide binding]; other site 155864002289 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 155864002290 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 155864002291 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 155864002292 active site turn [active] 155864002293 phosphorylation site [posttranslational modification] 155864002294 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 155864002295 HPr interaction site; other site 155864002296 glycerol kinase (GK) interaction site [polypeptide binding]; other site 155864002297 active site 155864002298 phosphorylation site [posttranslational modification] 155864002299 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 155864002300 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 155864002301 active site 155864002302 HIGH motif; other site 155864002303 nucleotide binding site [chemical binding]; other site 155864002304 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 155864002305 KMSKS motif; other site 155864002306 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 155864002307 outer membrane porin, OprD family; Region: OprD; pfam03573 155864002308 outer membrane porin, OprD family; Region: OprD; pfam03573 155864002309 YbfN-like lipoprotein; Region: YbfN; pfam13982 155864002310 ferric uptake regulator; Provisional; Region: fur; PRK09462 155864002311 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 155864002312 metal binding site 2 [ion binding]; metal-binding site 155864002313 putative DNA binding helix; other site 155864002314 metal binding site 1 [ion binding]; metal-binding site 155864002315 dimer interface [polypeptide binding]; other site 155864002316 structural Zn2+ binding site [ion binding]; other site 155864002317 flavodoxin FldA; Validated; Region: PRK09267 155864002318 LexA regulated protein; Provisional; Region: PRK11675 155864002319 acyl-CoA esterase; Provisional; Region: PRK10673 155864002320 PGAP1-like protein; Region: PGAP1; pfam07819 155864002321 replication initiation regulator SeqA; Provisional; Region: PRK11187 155864002322 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 155864002323 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 155864002324 active site 155864002325 substrate binding site [chemical binding]; other site 155864002326 metal binding site [ion binding]; metal-binding site 155864002327 putrescine transporter; Provisional; Region: potE; PRK10655 155864002328 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 155864002329 ornithine decarboxylase; Provisional; Region: PRK13578 155864002330 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 155864002331 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 155864002332 homodimer interface [polypeptide binding]; other site 155864002333 pyridoxal 5'-phosphate binding site [chemical binding]; other site 155864002334 catalytic residue [active] 155864002335 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 155864002336 O-island #32; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864002337 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 155864002338 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 155864002339 active site 155864002340 phosphorylation site [posttranslational modification] 155864002341 intermolecular recognition site; other site 155864002342 dimerization interface [polypeptide binding]; other site 155864002343 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 155864002344 DNA binding site [nucleotide binding] 155864002345 sensor protein KdpD; Provisional; Region: PRK10490 155864002346 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 155864002347 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 155864002348 Ligand Binding Site [chemical binding]; other site 155864002349 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 155864002350 GAF domain; Region: GAF_3; pfam13492 155864002351 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 155864002352 dimer interface [polypeptide binding]; other site 155864002353 phosphorylation site [posttranslational modification] 155864002354 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 155864002355 ATP binding site [chemical binding]; other site 155864002356 Mg2+ binding site [ion binding]; other site 155864002357 G-X-G motif; other site 155864002358 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 155864002359 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 155864002360 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 155864002361 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 155864002362 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 155864002363 PAAR motif; Region: PAAR_motif; cl15808 155864002364 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 155864002365 RHS Repeat; Region: RHS_repeat; pfam05593 155864002366 RHS Repeat; Region: RHS_repeat; pfam05593 155864002367 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 155864002368 RHS Repeat; Region: RHS_repeat; pfam05593 155864002369 RHS Repeat; Region: RHS_repeat; pfam05593 155864002370 RHS protein; Region: RHS; pfam03527 155864002371 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 155864002372 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 155864002373 RHS protein; Region: RHS; pfam03527 155864002374 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 155864002375 O-island #33; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864002376 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 155864002377 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 155864002378 Transposase [DNA replication, recombination, and repair]; Region: COG5433 155864002379 Transposase [DNA replication, recombination, and repair]; Region: COG5433 155864002380 O-island #34; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864002381 hypothetical protein; Provisional; Region: PRK10167 155864002382 Uncharacterized conserved protein [Function unknown]; Region: COG3272 155864002383 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 155864002384 DNA photolyase; Region: DNA_photolyase; pfam00875 155864002385 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 155864002386 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864002387 putative substrate translocation pore; other site 155864002388 POT family; Region: PTR2; pfam00854 155864002389 Uncharacterized conserved protein [Function unknown]; Region: COG0327 155864002390 metal-binding protein; Provisional; Region: PRK10799 155864002391 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 155864002392 sensor histidine kinase inhibitor, KipI family; Region: TIGR00370 155864002393 biotin-dependent carboxylase uncharacterized domain; Region: urea_amlyse_rel; TIGR00724 155864002394 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 155864002395 putative active site [active] 155864002396 endonuclease VIII; Provisional; Region: PRK10445 155864002397 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 155864002398 DNA binding site [nucleotide binding] 155864002399 catalytic residue [active] 155864002400 putative catalytic residues [active] 155864002401 H2TH interface [polypeptide binding]; other site 155864002402 intercalation triad [nucleotide binding]; other site 155864002403 substrate specificity determining residue; other site 155864002404 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 155864002405 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 155864002406 Putative ammonia monooxygenase; Region: AmoA; pfam05145 155864002407 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 155864002408 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 155864002409 Fimbrial protein; Region: Fimbrial; pfam00419 155864002410 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 155864002411 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 155864002412 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 155864002413 PapC C-terminal domain; Region: PapC_C; pfam13953 155864002414 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 155864002415 PapC N-terminal domain; Region: PapC_N; pfam13954 155864002416 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 155864002417 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 155864002418 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 155864002419 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 155864002420 dimer interface [polypeptide binding]; other site 155864002421 active site 155864002422 citrylCoA binding site [chemical binding]; other site 155864002423 NADH binding [chemical binding]; other site 155864002424 cationic pore residues; other site 155864002425 oxalacetate/citrate binding site [chemical binding]; other site 155864002426 coenzyme A binding site [chemical binding]; other site 155864002427 catalytic triad [active] 155864002428 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 155864002429 Iron-sulfur protein interface; other site 155864002430 proximal quinone binding site [chemical binding]; other site 155864002431 SdhD (CybS) interface [polypeptide binding]; other site 155864002432 proximal heme binding site [chemical binding]; other site 155864002433 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 155864002434 SdhC subunit interface [polypeptide binding]; other site 155864002435 proximal heme binding site [chemical binding]; other site 155864002436 cardiolipin binding site; other site 155864002437 Iron-sulfur protein interface; other site 155864002438 proximal quinone binding site [chemical binding]; other site 155864002439 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 155864002440 L-aspartate oxidase; Provisional; Region: PRK06175 155864002441 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 155864002442 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 155864002443 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 155864002444 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 155864002445 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 155864002446 TPP-binding site [chemical binding]; other site 155864002447 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 155864002448 dimer interface [polypeptide binding]; other site 155864002449 PYR/PP interface [polypeptide binding]; other site 155864002450 TPP binding site [chemical binding]; other site 155864002451 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 155864002452 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 155864002453 E3 interaction surface; other site 155864002454 lipoyl attachment site [posttranslational modification]; other site 155864002455 e3 binding domain; Region: E3_binding; pfam02817 155864002456 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 155864002457 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 155864002458 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 155864002459 CoA-ligase; Region: Ligase_CoA; pfam00549 155864002460 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 155864002461 CoA binding domain; Region: CoA_binding; smart00881 155864002462 CoA-ligase; Region: Ligase_CoA; pfam00549 155864002463 O-island #35; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864002464 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 155864002465 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 155864002466 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 155864002467 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 155864002468 dimerization interface [polypeptide binding]; other site 155864002469 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 155864002470 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 155864002471 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 155864002472 homodimer interface [polypeptide binding]; other site 155864002473 Walker A motif; other site 155864002474 ATP binding site [chemical binding]; other site 155864002475 hydroxycobalamin binding site [chemical binding]; other site 155864002476 Walker B motif; other site 155864002477 putative fumarate hydratase; Provisional; Region: PRK15392 155864002478 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 155864002479 Fumarase C-terminus; Region: Fumerase_C; pfam05683 155864002480 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 155864002481 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 155864002482 Domain of unknown function (DUF4387); Region: DUF4387; pfam14330 155864002483 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 155864002484 Methylaspartate ammonia-lyase [Amino acid transport and metabolism]; Region: Mal; COG3799 155864002485 Methylaspartate ammonia lyase (3-methylaspartase, MAL) is a homodimeric enzyme, catalyzing the magnesium-dependent reversible alpha,beta-elimination of ammonia from L-threo-(2S,3S)-3-methylaspartic acid to mesaconic acid. This reaction is part of the...; Region: MAL; cd03314 155864002486 dimer interface [polypeptide binding]; other site 155864002487 active site 155864002488 Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to...; Region: Glm_e; cd00245 155864002489 substrate binding site [chemical binding]; other site 155864002490 B12 cofactor binding site [chemical binding]; other site 155864002491 heterodimer (sigma-epsilon) interface [polypeptide binding]; other site 155864002492 homodimer (epsilon-epsilon) interface [polypeptide binding]; other site 155864002493 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 155864002494 conserved hypothetical protein; Region: glmL_fam; TIGR01319 155864002495 nucleotide binding site [chemical binding]; other site 155864002496 B12 binding domain of glutamate mutase (Glm). Glutamate mutase catalysis the conversion of (S)-glutamate with (2S,3S)-3-methylaspartate. The rearrangement reaction is initiated by the extraction of a hydrogen from the protein-bound substrate by a 5'...; Region: Glm_B12_BD; cd02072 155864002497 B12 binding site [chemical binding]; other site 155864002498 heterodimer interface [polypeptide binding]; other site 155864002499 cobalt ligand [ion binding]; other site 155864002500 O-island #35; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864002501 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 155864002502 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 155864002503 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 155864002504 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 155864002505 hypothetical protein; Provisional; Region: PRK10588 155864002506 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 155864002507 active site 155864002508 colicin uptake protein TolQ; Provisional; Region: PRK10801 155864002509 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 155864002510 colicin uptake protein TolR; Provisional; Region: PRK11024 155864002511 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 155864002512 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 155864002513 TolA C-terminal; Region: TolA; pfam06519 155864002514 translocation protein TolB; Provisional; Region: tolB; PRK03629 155864002515 TolB amino-terminal domain; Region: TolB_N; pfam04052 155864002516 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 155864002517 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 155864002518 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 155864002519 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 155864002520 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 155864002521 ligand binding site [chemical binding]; other site 155864002522 tol-pal system protein YbgF; Provisional; Region: PRK10803 155864002523 Tetratricopeptide repeat; Region: TPR_6; pfam13174 155864002524 Tetratricopeptide repeat; Region: TPR_6; pfam13174 155864002525 quinolinate synthetase; Provisional; Region: PRK09375 155864002526 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 155864002527 zinc transporter ZitB; Provisional; Region: PRK03557 155864002528 YbgS-like protein; Region: YbgS; pfam13985 155864002529 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 155864002530 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 155864002531 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 155864002532 catalytic core [active] 155864002533 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 155864002534 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 155864002535 active site 155864002536 catalytic residues [active] 155864002537 galactokinase; Provisional; Region: PRK05101 155864002538 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 155864002539 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 155864002540 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 155864002541 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 155864002542 dimer interface [polypeptide binding]; other site 155864002543 active site 155864002544 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 155864002545 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 155864002546 NAD binding site [chemical binding]; other site 155864002547 homodimer interface [polypeptide binding]; other site 155864002548 active site 155864002549 substrate binding site [chemical binding]; other site 155864002550 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 155864002551 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 155864002552 Walker A/P-loop; other site 155864002553 ATP binding site [chemical binding]; other site 155864002554 Q-loop/lid; other site 155864002555 ABC transporter signature motif; other site 155864002556 Walker B; other site 155864002557 D-loop; other site 155864002558 H-loop/switch region; other site 155864002559 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 155864002560 Walker A/P-loop; other site 155864002561 ATP binding site [chemical binding]; other site 155864002562 Q-loop/lid; other site 155864002563 ABC transporter signature motif; other site 155864002564 Walker B; other site 155864002565 D-loop; other site 155864002566 H-loop/switch region; other site 155864002567 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 155864002568 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 155864002569 molybdenum-pterin binding domain; Region: Mop; TIGR00638 155864002570 TOBE domain; Region: TOBE; pfam03459 155864002571 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 155864002572 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 155864002573 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 155864002574 substrate binding pocket [chemical binding]; other site 155864002575 membrane-bound complex binding site; other site 155864002576 hinge residues; other site 155864002577 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 155864002578 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 155864002579 putative PBP binding loops; other site 155864002580 ABC-ATPase subunit interface; other site 155864002581 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 155864002582 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 155864002583 Walker A/P-loop; other site 155864002584 ATP binding site [chemical binding]; other site 155864002585 Q-loop/lid; other site 155864002586 ABC transporter signature motif; other site 155864002587 Walker B; other site 155864002588 D-loop; other site 155864002589 H-loop/switch region; other site 155864002590 molybdenum-pterin binding domain; Region: Mop; TIGR00638 155864002591 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 155864002592 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 155864002593 motif II; other site 155864002594 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 155864002595 6-phosphogluconolactonase; Provisional; Region: PRK11028 155864002596 Transcriptional regulator [Transcription]; Region: LysR; COG0583 155864002597 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 155864002598 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 155864002599 putative dimerization interface [polypeptide binding]; other site 155864002600 PrpF protein; Region: PrpF; pfam04303 155864002601 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 155864002602 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 155864002603 transmembrane helices; other site 155864002604 putative hydratase; Provisional; Region: PRK11413 155864002605 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 155864002606 substrate binding site [chemical binding]; other site 155864002607 ligand binding site [chemical binding]; other site 155864002608 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 155864002609 substrate binding site [chemical binding]; other site 155864002610 acyl-CoA thioesterase; Provisional; Region: PRK10531 155864002611 putative pectinesterase; Region: PLN02432; cl01911 155864002612 O-island #36; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655; Cryptic prophage CP-933K; includes one copy of the 13 bp direct repeat that flanks the prophage 155864002613 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 155864002614 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 155864002615 dimer interface [polypeptide binding]; other site 155864002616 active site 155864002617 Int/Topo IB signature motif; other site 155864002618 Protein of unknown function (DUF1382); Region: DUF1382; pfam07131 155864002619 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 155864002620 RecT family; Region: RecT; cl04285 155864002621 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 155864002622 O-island #36; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655; Cryptic prophage CP-933K; includes one copy of the 13 bp direct repeat that flanks the prophage 155864002623 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 155864002624 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3528 155864002625 Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323 155864002626 Protein of unknown function (DUF3927); Region: DUF3927; pfam13064 155864002627 similar to hypothetical protein; No significant matches 155864002628 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 155864002629 catalytic residues [active] 155864002630 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 155864002631 Protein of unknown function (DUF1441); Region: DUF1441; pfam07278 155864002632 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 155864002633 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 155864002634 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 155864002635 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 155864002636 O-island #36; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655; Cryptic prophage CP-933K; includes one copy of the 13 bp direct repeat that flanks the prophage 155864002637 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 155864002638 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 155864002639 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 155864002640 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 155864002641 oligomer interface [polypeptide binding]; other site 155864002642 active site residues [active] 155864002643 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 155864002644 Uncharacterized conserved protein [Function unknown]; Region: COG5471 155864002645 ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; pfam13856 155864002646 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 155864002647 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 155864002648 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 155864002649 Bacterial Ig-like domain 2; Region: BID_2; smart00635 155864002650 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; cl06106 155864002651 Minor tail protein T; Region: Phage_tail_T; pfam06223 155864002652 Phage-related minor tail protein [Function unknown]; Region: COG5281 155864002653 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 155864002654 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 155864002655 Phage-related protein [Function unknown]; Region: COG4718 155864002656 Phage-related protein [Function unknown]; Region: gp18; COG4672 155864002657 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 155864002658 MPN+ (JAMM) motif; other site 155864002659 Zinc-binding site [ion binding]; other site 155864002660 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 155864002661 NlpC/P60 family; Region: NLPC_P60; cl17555 155864002662 Phage-related protein, tail component [Function unknown]; Region: COG4723 155864002663 Phage-related protein, tail component [Function unknown]; Region: COG4733 155864002664 Putative phage tail protein; Region: Phage-tail_3; pfam13550 155864002665 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 155864002666 Fibronectin type III protein; Region: DUF3672; pfam12421 155864002667 O-island #36; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655; Cryptic prophage CP-933K; includes one copy of the 13 bp direct repeat that flanks the prophage 155864002668 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 155864002669 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 155864002670 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 155864002671 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 155864002672 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 155864002673 non-LEE encoded effector protein NleB; Provisional; Region: PRK15382 155864002674 type III secretion system protein; Provisional; Region: PRK15384; cl14665 155864002675 NFkB-p65-degrading zinc protease; Region: Peptidase_M85; pfam13678 155864002676 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512 155864002677 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 155864002678 substrate binding site [chemical binding]; other site 155864002679 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 155864002680 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 155864002681 inhibitor-cofactor binding pocket; inhibition site 155864002682 pyridoxal 5'-phosphate binding site [chemical binding]; other site 155864002683 catalytic residue [active] 155864002684 biotin synthase; Provisional; Region: PRK15108 155864002685 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 155864002686 FeS/SAM binding site; other site 155864002687 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 155864002688 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 155864002689 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 155864002690 substrate-cofactor binding pocket; other site 155864002691 pyridoxal 5'-phosphate binding site [chemical binding]; other site 155864002692 catalytic residue [active] 155864002693 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 155864002694 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 155864002695 S-adenosylmethionine binding site [chemical binding]; other site 155864002696 AAA domain; Region: AAA_26; pfam13500 155864002697 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 155864002698 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 155864002699 ADP binding site [chemical binding]; other site 155864002700 excinuclease ABC subunit B; Provisional; Region: PRK05298 155864002701 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 155864002702 ATP binding site [chemical binding]; other site 155864002703 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 155864002704 nucleotide binding region [chemical binding]; other site 155864002705 ATP-binding site [chemical binding]; other site 155864002706 Ultra-violet resistance protein B; Region: UvrB; pfam12344 155864002707 UvrB/uvrC motif; Region: UVR; pfam02151 155864002708 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 155864002709 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 155864002710 putative substrate binding pocket [chemical binding]; other site 155864002711 dimer interface [polypeptide binding]; other site 155864002712 phosphate binding site [ion binding]; other site 155864002713 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 155864002714 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 155864002715 FeS/SAM binding site; other site 155864002716 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 155864002717 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 155864002718 MPT binding site; other site 155864002719 trimer interface [polypeptide binding]; other site 155864002720 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 155864002721 trimer interface [polypeptide binding]; other site 155864002722 dimer interface [polypeptide binding]; other site 155864002723 putative active site [active] 155864002724 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 155864002725 MoaE interaction surface [polypeptide binding]; other site 155864002726 MoeB interaction surface [polypeptide binding]; other site 155864002727 thiocarboxylated glycine; other site 155864002728 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 155864002729 MoaE homodimer interface [polypeptide binding]; other site 155864002730 MoaD interaction [polypeptide binding]; other site 155864002731 active site residues [active] 155864002732 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 155864002733 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 155864002734 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 155864002735 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 155864002736 Predicted integral membrane protein [Function unknown]; Region: COG0392 155864002737 cardiolipin synthase 2; Provisional; Region: PRK11263 155864002738 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 155864002739 putative active site [active] 155864002740 catalytic site [active] 155864002741 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 155864002742 putative active site [active] 155864002743 catalytic site [active] 155864002744 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 155864002745 putative catalytic site [active] 155864002746 putative metal binding site [ion binding]; other site 155864002747 putative phosphate binding site [ion binding]; other site 155864002748 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 155864002749 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 155864002750 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 155864002751 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 155864002752 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 155864002753 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 155864002754 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 155864002755 Walker A/P-loop; other site 155864002756 ATP binding site [chemical binding]; other site 155864002757 Q-loop/lid; other site 155864002758 ABC transporter signature motif; other site 155864002759 Walker B; other site 155864002760 D-loop; other site 155864002761 H-loop/switch region; other site 155864002762 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 155864002763 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 155864002764 Walker A/P-loop; other site 155864002765 ATP binding site [chemical binding]; other site 155864002766 Q-loop/lid; other site 155864002767 ABC transporter signature motif; other site 155864002768 Walker B; other site 155864002769 D-loop; other site 155864002770 H-loop/switch region; other site 155864002771 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 155864002772 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 155864002773 HlyD family secretion protein; Region: HlyD_3; pfam13437 155864002774 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 155864002775 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 155864002776 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 155864002777 helicase 45; Provisional; Region: PTZ00424 155864002778 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 155864002779 ATP binding site [chemical binding]; other site 155864002780 Mg++ binding site [ion binding]; other site 155864002781 motif III; other site 155864002782 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 155864002783 nucleotide binding region [chemical binding]; other site 155864002784 ATP-binding site [chemical binding]; other site 155864002785 O-island #37; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864002786 SopA-like central domain; Region: SopA; pfam13981 155864002787 SopA-like catalytic domain; Region: SopA_C; pfam13979 155864002788 O-island #37; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864002789 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 155864002790 DEAD_2; Region: DEAD_2; pfam06733 155864002791 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 155864002792 glycosyl transferase family protein; Provisional; Region: PRK08136 155864002793 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 155864002794 putative dehydrogenase; Provisional; Region: PRK10098 155864002795 hypothetical protein; Provisional; Region: PRK10259 155864002796 hypothetical protein; Provisional; Region: PRK11019 155864002797 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 155864002798 catecholate siderophore receptor Fiu; Provisional; Region: PRK09840 155864002799 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 155864002800 N-terminal plug; other site 155864002801 ligand-binding site [chemical binding]; other site 155864002802 hypothetical protein; Provisional; Region: PRK10259 155864002803 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 155864002804 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 155864002805 putative mechanosensitive channel protein; Provisional; Region: PRK11465 155864002806 Mechanosensitive ion channel; Region: MS_channel; pfam00924 155864002807 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 155864002808 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 155864002809 Walker A/P-loop; other site 155864002810 ATP binding site [chemical binding]; other site 155864002811 Q-loop/lid; other site 155864002812 ABC transporter signature motif; other site 155864002813 Walker B; other site 155864002814 D-loop; other site 155864002815 H-loop/switch region; other site 155864002816 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 155864002817 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 155864002818 dimer interface [polypeptide binding]; other site 155864002819 conserved gate region; other site 155864002820 putative PBP binding loops; other site 155864002821 ABC-ATPase subunit interface; other site 155864002822 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 155864002823 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 155864002824 substrate binding pocket [chemical binding]; other site 155864002825 membrane-bound complex binding site; other site 155864002826 hinge residues; other site 155864002827 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 155864002828 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 155864002829 dimerization interface [polypeptide binding]; other site 155864002830 DPS ferroxidase diiron center [ion binding]; other site 155864002831 ion pore; other site 155864002832 threonine and homoserine efflux system; Provisional; Region: PRK10532 155864002833 EamA-like transporter family; Region: EamA; pfam00892 155864002834 outer membrane protein X; Provisional; Region: ompX; PRK09408 155864002835 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 155864002836 Sulfatase; Region: Sulfatase; pfam00884 155864002837 manganese transport regulator MntR; Provisional; Region: PRK11050 155864002838 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 155864002839 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 155864002840 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 155864002841 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 155864002842 transmembrane helices; other site 155864002843 L,D-transpeptidase; Provisional; Region: PRK10260 155864002844 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 155864002845 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 155864002846 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 155864002847 Walker A/P-loop; other site 155864002848 ATP binding site [chemical binding]; other site 155864002849 Q-loop/lid; other site 155864002850 ABC transporter signature motif; other site 155864002851 Walker B; other site 155864002852 D-loop; other site 155864002853 H-loop/switch region; other site 155864002854 ABC transporter; Region: ABC_tran_2; pfam12848 155864002855 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 155864002856 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 155864002857 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 155864002858 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 155864002859 active site 155864002860 motif I; other site 155864002861 motif II; other site 155864002862 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 155864002863 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 155864002864 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 155864002865 dimer interface [polypeptide binding]; other site 155864002866 active site 155864002867 glycine loop; other site 155864002868 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 155864002869 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 155864002870 active site 155864002871 intersubunit interactions; other site 155864002872 catalytic residue [active] 155864002873 O-island #38; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864002874 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 155864002875 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 155864002876 ATP binding site [chemical binding]; other site 155864002877 substrate interface [chemical binding]; other site 155864002878 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 155864002879 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 155864002880 dimer interface [polypeptide binding]; other site 155864002881 putative functional site; other site 155864002882 putative MPT binding site; other site 155864002883 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 155864002884 catalytic nucleophile [active] 155864002885 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 155864002886 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 155864002887 Walker A/P-loop; other site 155864002888 ATP binding site [chemical binding]; other site 155864002889 Q-loop/lid; other site 155864002890 ABC transporter signature motif; other site 155864002891 Walker B; other site 155864002892 D-loop; other site 155864002893 H-loop/switch region; other site 155864002894 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 155864002895 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 155864002896 Walker A/P-loop; other site 155864002897 ATP binding site [chemical binding]; other site 155864002898 Q-loop/lid; other site 155864002899 ABC transporter signature motif; other site 155864002900 Walker B; other site 155864002901 D-loop; other site 155864002902 H-loop/switch region; other site 155864002903 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 155864002904 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 155864002905 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 155864002906 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 155864002907 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 155864002908 dimer interface [polypeptide binding]; other site 155864002909 conserved gate region; other site 155864002910 putative PBP binding loops; other site 155864002911 ABC-ATPase subunit interface; other site 155864002912 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 155864002913 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 155864002914 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 155864002915 dimer interface [polypeptide binding]; other site 155864002916 conserved gate region; other site 155864002917 putative PBP binding loops; other site 155864002918 ABC-ATPase subunit interface; other site 155864002919 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 155864002920 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 155864002921 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 155864002922 metal binding site [ion binding]; metal-binding site 155864002923 active site 155864002924 I-site; other site 155864002925 O-island #39; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864002926 Predicted transcriptional regulator [Transcription]; Region: COG2944 155864002927 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 155864002928 non-specific DNA binding site [nucleotide binding]; other site 155864002929 salt bridge; other site 155864002930 sequence-specific DNA binding site [nucleotide binding]; other site 155864002931 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4737 155864002932 O-island #39; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864002933 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 155864002934 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 155864002935 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 155864002936 FeS/SAM binding site; other site 155864002937 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 155864002938 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 155864002939 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 155864002940 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 155864002941 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 155864002942 putative C-terminal domain interface [polypeptide binding]; other site 155864002943 putative GSH binding site (G-site) [chemical binding]; other site 155864002944 putative dimer interface [polypeptide binding]; other site 155864002945 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 155864002946 N-terminal domain interface [polypeptide binding]; other site 155864002947 dimer interface [polypeptide binding]; other site 155864002948 substrate binding pocket (H-site) [chemical binding]; other site 155864002949 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 155864002950 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 155864002951 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 155864002952 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 155864002953 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 155864002954 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 155864002955 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 155864002956 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 155864002957 active site 155864002958 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 155864002959 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864002960 putative substrate translocation pore; other site 155864002961 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 155864002962 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 155864002963 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 155864002964 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864002965 putative substrate translocation pore; other site 155864002966 Major Facilitator Superfamily; Region: MFS_1; pfam07690 155864002967 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 155864002968 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 155864002969 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 155864002970 putative transporter; Provisional; Region: PRK04972 155864002971 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 155864002972 TrkA-C domain; Region: TrkA_C; pfam02080 155864002973 TrkA-C domain; Region: TrkA_C; pfam02080 155864002974 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 155864002975 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 155864002976 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 155864002977 GSH binding site [chemical binding]; other site 155864002978 catalytic residues [active] 155864002979 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 155864002980 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 155864002981 dimer interface [polypeptide binding]; other site 155864002982 FMN binding site [chemical binding]; other site 155864002983 NADPH bind site [chemical binding]; other site 155864002984 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 155864002985 RimK-like ATP-grasp domain; Region: RimK; pfam08443 155864002986 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 155864002987 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 155864002988 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 155864002989 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 155864002990 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 155864002991 Walker A/P-loop; other site 155864002992 ATP binding site [chemical binding]; other site 155864002993 Q-loop/lid; other site 155864002994 ABC transporter signature motif; other site 155864002995 Walker B; other site 155864002996 D-loop; other site 155864002997 H-loop/switch region; other site 155864002998 TOBE domain; Region: TOBE_2; pfam08402 155864002999 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 155864003000 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 155864003001 dimer interface [polypeptide binding]; other site 155864003002 conserved gate region; other site 155864003003 putative PBP binding loops; other site 155864003004 ABC-ATPase subunit interface; other site 155864003005 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 155864003006 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 155864003007 dimer interface [polypeptide binding]; other site 155864003008 conserved gate region; other site 155864003009 putative PBP binding loops; other site 155864003010 ABC-ATPase subunit interface; other site 155864003011 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 155864003012 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 155864003013 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 155864003014 S-adenosylmethionine binding site [chemical binding]; other site 155864003015 O-island #40; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864003016 O-island #40; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864003017 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 155864003018 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 155864003019 active site 155864003020 P-loop; other site 155864003021 phosphorylation site [posttranslational modification] 155864003022 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 155864003023 Sulfatase; Region: Sulfatase; cl17466 155864003024 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 155864003025 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 155864003026 substrate binding pocket [chemical binding]; other site 155864003027 membrane-bound complex binding site; other site 155864003028 hinge residues; other site 155864003029 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 155864003030 dimer interface [polypeptide binding]; other site 155864003031 conserved gate region; other site 155864003032 putative PBP binding loops; other site 155864003033 ABC-ATPase subunit interface; other site 155864003034 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 155864003035 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 155864003036 dimer interface [polypeptide binding]; other site 155864003037 conserved gate region; other site 155864003038 putative PBP binding loops; other site 155864003039 ABC-ATPase subunit interface; other site 155864003040 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 155864003041 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 155864003042 substrate binding pocket [chemical binding]; other site 155864003043 membrane-bound complex binding site; other site 155864003044 hinge residues; other site 155864003045 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 155864003046 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 155864003047 Walker A/P-loop; other site 155864003048 ATP binding site [chemical binding]; other site 155864003049 Q-loop/lid; other site 155864003050 ABC transporter signature motif; other site 155864003051 Walker B; other site 155864003052 D-loop; other site 155864003053 H-loop/switch region; other site 155864003054 putative lipoprotein; Provisional; Region: PRK10533 155864003055 O-island #41; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864003056 O-island #41; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864003057 hypothetical protein; Provisional; Region: PRK02877 155864003058 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 155864003059 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 155864003060 amidase catalytic site [active] 155864003061 Zn binding residues [ion binding]; other site 155864003062 substrate binding site [chemical binding]; other site 155864003063 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 155864003064 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 155864003065 NAD(P) binding site [chemical binding]; other site 155864003066 active site 155864003067 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 155864003068 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 155864003069 putative NAD(P) binding site [chemical binding]; other site 155864003070 putative active site [active] 155864003071 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 155864003072 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 155864003073 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 155864003074 tetramer interface [polypeptide binding]; other site 155864003075 pyridoxal 5'-phosphate binding site [chemical binding]; other site 155864003076 catalytic residue [active] 155864003077 pyruvate dehydrogenase; Provisional; Region: PRK09124 155864003078 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 155864003079 PYR/PP interface [polypeptide binding]; other site 155864003080 dimer interface [polypeptide binding]; other site 155864003081 tetramer interface [polypeptide binding]; other site 155864003082 TPP binding site [chemical binding]; other site 155864003083 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 155864003084 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 155864003085 TPP-binding site [chemical binding]; other site 155864003086 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 155864003087 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 155864003088 FAD binding pocket [chemical binding]; other site 155864003089 FAD binding motif [chemical binding]; other site 155864003090 phosphate binding motif [ion binding]; other site 155864003091 beta-alpha-beta structure motif; other site 155864003092 NAD binding pocket [chemical binding]; other site 155864003093 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 155864003094 catalytic loop [active] 155864003095 iron binding site [ion binding]; other site 155864003096 hybrid cluster protein; Provisional; Region: PRK05290 155864003097 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 155864003098 ACS interaction site; other site 155864003099 CODH interaction site; other site 155864003100 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 155864003101 hybrid metal cluster; other site 155864003102 Predicted membrane protein [Function unknown]; Region: COG2431 155864003103 O-island #42; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864003104 O-island #42; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864003105 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 155864003106 amphipathic channel; other site 155864003107 Asn-Pro-Ala signature motifs; other site 155864003108 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 155864003109 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 155864003110 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 155864003111 putative active site [active] 155864003112 putative metal-binding site [ion binding]; other site 155864003113 Protein of unknown function (DUF535); Region: DUF535; pfam04393 155864003114 macrolide transporter subunit MacA; Provisional; Region: PRK11578 155864003115 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 155864003116 HlyD family secretion protein; Region: HlyD_3; pfam13437 155864003117 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 155864003118 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 155864003119 Walker A/P-loop; other site 155864003120 ATP binding site [chemical binding]; other site 155864003121 Q-loop/lid; other site 155864003122 ABC transporter signature motif; other site 155864003123 Walker B; other site 155864003124 D-loop; other site 155864003125 H-loop/switch region; other site 155864003126 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 155864003127 FtsX-like permease family; Region: FtsX; pfam02687 155864003128 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 155864003129 DNA-binding site [nucleotide binding]; DNA binding site 155864003130 RNA-binding motif; other site 155864003131 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 155864003132 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 155864003133 Clp amino terminal domain; Region: Clp_N; pfam02861 155864003134 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 155864003135 Walker A motif; other site 155864003136 ATP binding site [chemical binding]; other site 155864003137 Walker B motif; other site 155864003138 arginine finger; other site 155864003139 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 155864003140 Walker A motif; other site 155864003141 ATP binding site [chemical binding]; other site 155864003142 Walker B motif; other site 155864003143 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 155864003144 O-island #43; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864003145 integrase; Provisional; Region: PRK09692 155864003146 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 155864003147 active site 155864003148 Int/Topo IB signature motif; other site 155864003149 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 155864003150 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 155864003151 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 155864003152 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 155864003153 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 155864003154 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 155864003155 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 155864003156 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 155864003157 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4951 155864003158 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 155864003159 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 155864003160 ATP binding site [chemical binding]; other site 155864003161 putative Mg++ binding site [ion binding]; other site 155864003162 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 155864003163 nucleotide binding region [chemical binding]; other site 155864003164 ATP-binding site [chemical binding]; other site 155864003165 O-island #43; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864003166 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 155864003167 homodimer interface [polypeptide binding]; other site 155864003168 putative GKAP docking site [polypeptide binding]; other site 155864003169 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 155864003170 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 155864003171 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 155864003172 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 155864003173 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 155864003174 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 155864003175 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 155864003176 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 155864003177 DNA-binding interface [nucleotide binding]; DNA binding site 155864003178 Helix-turn-helix domain; Region: HTH_38; pfam13936 155864003179 putative transposase OrfB; Reviewed; Region: PHA02517 155864003180 Integrase core domain; Region: rve; pfam00665 155864003181 Integrase core domain; Region: rve_3; pfam13683 155864003182 Enterobacterial TraT complement resistance protein; Region: TraT; pfam05818 155864003183 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 155864003184 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 155864003185 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 155864003186 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 155864003187 Sulfatase; Region: Sulfatase; pfam00884 155864003188 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 155864003189 O-island #43; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864003190 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 155864003191 alpha-gamma subunit interface [polypeptide binding]; other site 155864003192 beta-gamma subunit interface [polypeptide binding]; other site 155864003193 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 155864003194 gamma-beta subunit interface [polypeptide binding]; other site 155864003195 alpha-beta subunit interface [polypeptide binding]; other site 155864003196 urease subunit alpha; Reviewed; Region: ureC; PRK13207 155864003197 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 155864003198 subunit interactions [polypeptide binding]; other site 155864003199 active site 155864003200 flap region; other site 155864003201 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 155864003202 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 155864003203 dimer interface [polypeptide binding]; other site 155864003204 catalytic residues [active] 155864003205 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 155864003206 UreF; Region: UreF; pfam01730 155864003207 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 155864003208 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 155864003209 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 155864003210 Transposase; Region: HTH_Tnp_1; pfam01527 155864003211 conjugal transfer surface exclusion protein TraT; Provisional; Region: PRK13731 155864003212 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 155864003213 Hok/gef family; Region: HOK_GEF; pfam01848 155864003214 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 155864003215 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 155864003216 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 155864003217 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 155864003218 Transposase; Region: HTH_Tnp_1; pfam01527 155864003219 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 155864003220 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 155864003221 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 155864003222 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 155864003223 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 155864003224 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 155864003225 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 155864003226 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 155864003227 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 155864003228 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 155864003229 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 155864003230 O-island #43; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864003231 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 155864003232 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 155864003233 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 155864003234 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 155864003235 Protein of unknown function (DUF2983); Region: DUF2983; pfam11202 155864003236 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 155864003237 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 155864003238 active site 155864003239 Protein of unknown function (DUF3706); Region: DUF3706; pfam12500 155864003240 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 155864003241 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 155864003242 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 155864003243 putative metal binding site [ion binding]; other site 155864003244 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 155864003245 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 155864003246 putative metal binding site [ion binding]; other site 155864003247 Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110 155864003248 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 155864003249 putative metal binding site [ion binding]; other site 155864003250 tellurite resistance protein terB; Region: terB; cd07176 155864003251 putative metal binding site [ion binding]; other site 155864003252 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 155864003253 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 155864003254 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 155864003255 putative metal binding site [ion binding]; other site 155864003256 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 155864003257 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 155864003258 putative metal binding site [ion binding]; other site 155864003259 O-island #43; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864003260 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 155864003261 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 155864003262 putative metal binding site [ion binding]; other site 155864003263 bifunctional enterobactin receptor/adhesin protein; Provisional; Region: PRK13486 155864003264 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 155864003265 N-terminal plug; other site 155864003266 ligand-binding site [chemical binding]; other site 155864003267 similar to hypothetical protein; No significant matches 155864003268 bifunctional enterobactin receptor/adhesin protein; Provisional; Region: PRK13486 155864003269 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 155864003270 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 155864003271 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 155864003272 homodimer interface [polypeptide binding]; other site 155864003273 TDP-binding site; other site 155864003274 O-island #43; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864003275 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 155864003276 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 155864003277 Helix-turn-helix domain; Region: HTH_39; pfam14090 155864003278 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 155864003279 putative transposase OrfB; Reviewed; Region: PHA02517 155864003280 HTH-like domain; Region: HTH_21; pfam13276 155864003281 Integrase core domain; Region: rve; pfam00665 155864003282 Integrase core domain; Region: rve_3; pfam13683 155864003283 Transposase; Region: HTH_Tnp_1; cl17663 155864003284 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 155864003285 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 155864003286 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 155864003287 adhesin HecA family 20-residue repeat (two copies); Region: fil_hemag_20aa; TIGR01731 155864003288 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 155864003289 Part of AAA domain; Region: AAA_19; pfam13245 155864003290 AAA domain; Region: AAA_12; pfam13087 155864003291 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 155864003292 O-island #43; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864003293 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 155864003294 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 155864003295 Active Sites [active] 155864003296 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 155864003297 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 155864003298 ParB-like nuclease domain; Region: ParB; smart00470 155864003299 Integrase core domain; Region: rve_3; cl15866 155864003300 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 155864003301 Transposase; Region: HTH_Tnp_1; pfam01527 155864003302 Predicted GTPase [General function prediction only]; Region: COG3596 155864003303 YfjP GTPase; Region: YfjP; cd11383 155864003304 G1 box; other site 155864003305 GTP/Mg2+ binding site [chemical binding]; other site 155864003306 Switch I region; other site 155864003307 G2 box; other site 155864003308 Switch II region; other site 155864003309 G3 box; other site 155864003310 G4 box; other site 155864003311 G5 box; other site 155864003312 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 155864003313 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 155864003314 hypothetical protein; Provisional; Region: PRK09945 155864003315 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 155864003316 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 155864003317 Autotransporter beta-domain; Region: Autotransporter; smart00869 155864003318 hypothetical protein; Provisional; Region: PRK09866 155864003319 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 155864003320 G1 box; other site 155864003321 GTP/Mg2+ binding site [chemical binding]; other site 155864003322 G2 box; other site 155864003323 Switch I region; other site 155864003324 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 155864003325 G3 box; other site 155864003326 Switch II region; other site 155864003327 GTP/Mg2+ binding site [chemical binding]; other site 155864003328 G4 box; other site 155864003329 G5 box; other site 155864003330 YjcZ-like protein; Region: YjcZ; pfam13990 155864003331 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 155864003332 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 155864003333 nucleophile elbow; other site 155864003334 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 155864003335 O-island #43; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864003336 Domain of unknown function (DUF932); Region: DUF932; pfam06067 155864003337 Antirestriction protein; Region: Antirestrict; pfam03230 155864003338 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 155864003339 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 155864003340 MPN+ (JAMM) motif; other site 155864003341 Zinc-binding site [ion binding]; other site 155864003342 Protein of unknown function (DUF987); Region: DUF987; pfam06174 155864003343 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 155864003344 putative transposase OrfB; Reviewed; Region: PHA02517 155864003345 HTH-like domain; Region: HTH_21; pfam13276 155864003346 Integrase core domain; Region: rve; pfam00665 155864003347 Integrase core domain; Region: rve_3; pfam13683 155864003348 Transposase; Region: HTH_Tnp_1; cl17663 155864003349 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 155864003350 Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117 155864003351 Methyltransferase domain; Region: Methyltransf_27; pfam13708 155864003352 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 155864003353 rRNA binding site [nucleotide binding]; other site 155864003354 predicted 30S ribosome binding site; other site 155864003355 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 155864003356 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 155864003357 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 155864003358 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 155864003359 Walker A/P-loop; other site 155864003360 ATP binding site [chemical binding]; other site 155864003361 Q-loop/lid; other site 155864003362 ABC transporter signature motif; other site 155864003363 Walker B; other site 155864003364 D-loop; other site 155864003365 H-loop/switch region; other site 155864003366 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 155864003367 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 155864003368 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 155864003369 Walker A/P-loop; other site 155864003370 ATP binding site [chemical binding]; other site 155864003371 Q-loop/lid; other site 155864003372 ABC transporter signature motif; other site 155864003373 Walker B; other site 155864003374 D-loop; other site 155864003375 H-loop/switch region; other site 155864003376 thioredoxin reductase; Provisional; Region: PRK10262 155864003377 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 155864003378 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 155864003379 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 155864003380 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 155864003381 putative DNA binding site [nucleotide binding]; other site 155864003382 putative Zn2+ binding site [ion binding]; other site 155864003383 AsnC family; Region: AsnC_trans_reg; pfam01037 155864003384 DNA translocase FtsK; Provisional; Region: PRK10263 155864003385 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 155864003386 DNA translocase FtsK; Provisional; Region: PRK10263 155864003387 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 155864003388 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 155864003389 periplasmic chaperone LolA; Region: lolA; TIGR00547 155864003390 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 155864003391 recombination factor protein RarA; Reviewed; Region: PRK13342 155864003392 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 155864003393 Walker A motif; other site 155864003394 ATP binding site [chemical binding]; other site 155864003395 Walker B motif; other site 155864003396 arginine finger; other site 155864003397 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 155864003398 seryl-tRNA synthetase; Provisional; Region: PRK05431 155864003399 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 155864003400 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 155864003401 dimer interface [polypeptide binding]; other site 155864003402 active site 155864003403 motif 1; other site 155864003404 motif 2; other site 155864003405 motif 3; other site 155864003406 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 155864003407 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 155864003408 putative [Fe4-S4] binding site [ion binding]; other site 155864003409 putative molybdopterin cofactor binding site [chemical binding]; other site 155864003410 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 155864003411 putative molybdopterin cofactor binding site; other site 155864003412 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 155864003413 4Fe-4S binding domain; Region: Fer4; pfam00037 155864003414 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 155864003415 Isochorismatase family; Region: Isochorismatase; pfam00857 155864003416 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 155864003417 catalytic triad [active] 155864003418 dimer interface [polypeptide binding]; other site 155864003419 conserved cis-peptide bond; other site 155864003420 putative MFS family transporter protein; Provisional; Region: PRK03633 155864003421 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864003422 putative substrate translocation pore; other site 155864003423 Amino acid permease; Region: AA_permease_2; pfam13520 155864003424 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 155864003425 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 155864003426 FeS/SAM binding site; other site 155864003427 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 155864003428 Pyruvate formate lyase 1; Region: PFL1; cd01678 155864003429 coenzyme A binding site [chemical binding]; other site 155864003430 active site 155864003431 catalytic residues [active] 155864003432 glycine loop; other site 155864003433 formate transporter; Provisional; Region: PRK10805 155864003434 uncharacterized domain; Region: TIGR00702 155864003435 YcaO-like family; Region: YcaO; pfam02624 155864003436 Predicted membrane protein [Function unknown]; Region: COG2323 155864003437 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 155864003438 homodimer interface [polypeptide binding]; other site 155864003439 substrate-cofactor binding pocket; other site 155864003440 pyridoxal 5'-phosphate binding site [chemical binding]; other site 155864003441 catalytic residue [active] 155864003442 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 155864003443 Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554 155864003444 hinge; other site 155864003445 active site 155864003446 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 155864003447 cytidylate kinase; Provisional; Region: cmk; PRK00023 155864003448 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 155864003449 CMP-binding site; other site 155864003450 The sites determining sugar specificity; other site 155864003451 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 155864003452 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 155864003453 RNA binding site [nucleotide binding]; other site 155864003454 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 155864003455 RNA binding site [nucleotide binding]; other site 155864003456 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 155864003457 RNA binding site [nucleotide binding]; other site 155864003458 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 155864003459 RNA binding site [nucleotide binding]; other site 155864003460 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 155864003461 RNA binding site [nucleotide binding]; other site 155864003462 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 155864003463 IHF dimer interface [polypeptide binding]; other site 155864003464 IHF - DNA interface [nucleotide binding]; other site 155864003465 ComEC family competence protein; Provisional; Region: PRK11539 155864003466 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 155864003467 ComEC/Rec2-related protein; Region: ComEC_N-term; TIGR00360 155864003468 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 155864003469 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 155864003470 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 155864003471 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 155864003472 Walker A/P-loop; other site 155864003473 ATP binding site [chemical binding]; other site 155864003474 Q-loop/lid; other site 155864003475 ABC transporter signature motif; other site 155864003476 Walker B; other site 155864003477 D-loop; other site 155864003478 H-loop/switch region; other site 155864003479 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 155864003480 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 155864003481 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 155864003482 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 155864003483 hypothetical protein; Provisional; Region: PRK11827 155864003484 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 155864003485 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 155864003486 Ligand binding site; other site 155864003487 oligomer interface; other site 155864003488 hypothetical protein; Provisional; Region: PRK10593 155864003489 Uncharacterized conserved protein [Function unknown]; Region: COG1434 155864003490 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 155864003491 putative active site [active] 155864003492 Methyltransferase domain; Region: Methyltransf_31; pfam13847 155864003493 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 155864003494 S-adenosylmethionine binding site [chemical binding]; other site 155864003495 condesin subunit F; Provisional; Region: PRK05260 155864003496 condesin subunit E; Provisional; Region: PRK05256 155864003497 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 155864003498 MukB N-terminal; Region: MukB; pfam04310 155864003499 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 155864003500 murein L,D-transpeptidase; Provisional; Region: PRK10594 155864003501 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 155864003502 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 155864003503 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 155864003504 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 155864003505 Peptidase M15; Region: Peptidase_M15_3; cl01194 155864003506 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 155864003507 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 155864003508 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 155864003509 pyridoxal 5'-phosphate binding site [chemical binding]; other site 155864003510 homodimer interface [polypeptide binding]; other site 155864003511 catalytic residue [active] 155864003512 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 155864003513 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 155864003514 trimer interface [polypeptide binding]; other site 155864003515 eyelet of channel; other site 155864003516 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 155864003517 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 155864003518 putative dimer interface [polypeptide binding]; other site 155864003519 putative anticodon binding site; other site 155864003520 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 155864003521 homodimer interface [polypeptide binding]; other site 155864003522 motif 1; other site 155864003523 motif 2; other site 155864003524 active site 155864003525 motif 3; other site 155864003526 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 155864003527 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 155864003528 active site 155864003529 aminopeptidase N; Provisional; Region: pepN; PRK14015 155864003530 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 155864003531 active site 155864003532 Zn binding site [ion binding]; other site 155864003533 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 155864003534 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 155864003535 Walker A/P-loop; other site 155864003536 ATP binding site [chemical binding]; other site 155864003537 Q-loop/lid; other site 155864003538 ABC transporter signature motif; other site 155864003539 Walker B; other site 155864003540 D-loop; other site 155864003541 H-loop/switch region; other site 155864003542 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 155864003543 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 155864003544 dimer interface [polypeptide binding]; other site 155864003545 conserved gate region; other site 155864003546 putative PBP binding loops; other site 155864003547 ABC-ATPase subunit interface; other site 155864003548 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 155864003549 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 155864003550 active site 155864003551 dimer interface [polypeptide binding]; other site 155864003552 non-prolyl cis peptide bond; other site 155864003553 insertion regions; other site 155864003554 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 155864003555 substrate binding pocket [chemical binding]; other site 155864003556 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 155864003557 membrane-bound complex binding site; other site 155864003558 hinge residues; other site 155864003559 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 155864003560 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 155864003561 Fimbrial protein; Region: Fimbrial; cl01416 155864003562 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 155864003563 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 155864003564 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 155864003565 outer membrane usher protein; Provisional; Region: PRK15193 155864003566 PapC N-terminal domain; Region: PapC_N; pfam13954 155864003567 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 155864003568 PapC C-terminal domain; Region: PapC_C; pfam13953 155864003569 Fimbrial protein; Region: Fimbrial; cl01416 155864003570 Fimbrial protein; Region: Fimbrial; cl01416 155864003571 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 155864003572 putativi pili assembly chaperone; Provisional; Region: PRK11385 155864003573 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 155864003574 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 155864003575 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 155864003576 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 155864003577 quinone interaction residues [chemical binding]; other site 155864003578 active site 155864003579 catalytic residues [active] 155864003580 FMN binding site [chemical binding]; other site 155864003581 substrate binding site [chemical binding]; other site 155864003582 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 155864003583 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 155864003584 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 155864003585 MOSC domain; Region: MOSC; pfam03473 155864003586 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 155864003587 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 155864003588 catalytic loop [active] 155864003589 iron binding site [ion binding]; other site 155864003590 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 155864003591 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 155864003592 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 155864003593 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 155864003594 S-adenosylmethionine binding site [chemical binding]; other site 155864003595 ABC transporter ATPase component; Reviewed; Region: PRK11147 155864003596 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 155864003597 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 155864003598 Walker A/P-loop; other site 155864003599 Walker A/P-loop; other site 155864003600 ATP binding site [chemical binding]; other site 155864003601 ATP binding site [chemical binding]; other site 155864003602 Q-loop/lid; other site 155864003603 Q-loop/lid; other site 155864003604 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 155864003605 ABC transporter signature motif; other site 155864003606 Walker B; other site 155864003607 D-loop; other site 155864003608 ABC transporter; Region: ABC_tran_2; pfam12848 155864003609 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 155864003610 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 155864003611 Paraquat-inducible protein A; Region: PqiA; pfam04403 155864003612 Paraquat-inducible protein A; Region: PqiA; pfam04403 155864003613 paraquat-inducible protein B; Provisional; Region: PRK10807 155864003614 mce related protein; Region: MCE; pfam02470 155864003615 mce related protein; Region: MCE; pfam02470 155864003616 mce related protein; Region: MCE; pfam02470 155864003617 DASH complex subunit Duo1; Region: DASH_Duo1; pfam08651 155864003618 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 155864003619 Protein of unknown function (DUF330); Region: DUF330; pfam03886 155864003620 ribosome modulation factor; Provisional; Region: PRK14563 155864003621 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 155864003622 active site 1 [active] 155864003623 dimer interface [polypeptide binding]; other site 155864003624 active site 2 [active] 155864003625 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 155864003626 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 155864003627 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 155864003628 outer membrane protein A; Reviewed; Region: PRK10808 155864003629 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 155864003630 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 155864003631 ligand binding site [chemical binding]; other site 155864003632 cell division inhibitor SulA; Region: sula; TIGR00623 155864003633 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 155864003634 TfoX C-terminal domain; Region: TfoX_C; pfam04994 155864003635 TIGR01666 family membrane protein; Region: YCCS 155864003636 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 155864003637 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 155864003638 Predicted membrane protein [Function unknown]; Region: COG3304 155864003639 Domain of unknown function (DUF307); Region: DUF307; pfam03733 155864003640 Domain of unknown function (DUF307); Region: DUF307; pfam03733 155864003641 DNA helicase IV; Provisional; Region: helD; PRK11054 155864003642 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 155864003643 Part of AAA domain; Region: AAA_19; pfam13245 155864003644 Family description; Region: UvrD_C_2; pfam13538 155864003645 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 155864003646 active site 155864003647 dimer interfaces [polypeptide binding]; other site 155864003648 catalytic residues [active] 155864003649 hypothetical protein; Provisional; Region: PRK03641 155864003650 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110 155864003651 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 155864003652 heat shock protein HspQ; Provisional; Region: PRK14129 155864003653 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 155864003654 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 155864003655 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 155864003656 putative RNA binding site [nucleotide binding]; other site 155864003657 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 155864003658 S-adenosylmethionine binding site [chemical binding]; other site 155864003659 Acylphosphatase; Region: Acylphosphatase; cl00551 155864003660 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 155864003661 sulfur transfer protein TusE; Provisional; Region: PRK11508 155864003662 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 155864003663 YccA-like proteins; Region: YccA_like; cd10433 155864003664 O-island #44; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864003665 Cryptic prophage CP-933M; includes one copy of the 60 bp direct repeat that flanks the prophage 155864003666 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 155864003667 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 155864003668 dimer interface [polypeptide binding]; other site 155864003669 active site 155864003670 Int/Topo IB signature motif; other site 155864003671 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 155864003672 active site 155864003673 substrate binding site [chemical binding]; other site 155864003674 catalytic site [active] 155864003675 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 155864003676 DicB protein; Region: DicB; pfam05358 155864003677 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 155864003678 transcriptional repressor DicA; Reviewed; Region: PRK09706 155864003679 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 155864003680 non-specific DNA binding site [nucleotide binding]; other site 155864003681 salt bridge; other site 155864003682 sequence-specific DNA binding site [nucleotide binding]; other site 155864003683 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 155864003684 Cryptic prophage CP-933M; includes one copy of the 60 bp direct repeat that flanks the prophage; O-island #44; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864003685 primosomal protein DnaI; Provisional; Region: PRK02854 155864003686 putative replication protein; Provisional; Region: PRK12377 155864003687 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 155864003688 Walker A motif; other site 155864003689 ATP binding site [chemical binding]; other site 155864003690 Walker B motif; other site 155864003691 arginine finger; other site 155864003692 Protein of unknown function (DUF1627); Region: DUF1627; pfam07789 155864003693 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 155864003694 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 155864003695 Hok/gef family; Region: HOK_GEF; pfam01848 155864003696 Protein of unknown function (DUF968); Region: DUF968; pfam06147 155864003697 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 155864003698 Antitermination protein; Region: Antiterm; pfam03589 155864003699 Antitermination protein; Region: Antiterm; pfam03589 155864003700 tellurite resistance protein terB; Region: terB; cd07176 155864003701 putative metal binding site [ion binding]; other site 155864003702 Protein of unknown function (DUF3927); Region: DUF3927; pfam13064 155864003703 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 155864003704 Domain of unknown function (DUF303); Region: DUF303; pfam03629 155864003705 Cryptic prophage CP-933M; includes one copy of the 60 bp direct repeat that flanks the prophage; O-island #44; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864003706 Lysis protein S; Region: Lysis_S; pfam04971 155864003707 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 155864003708 Phage-related lysozyme (muraminidase) [General function prediction only]; Region: COG3772 155864003709 catalytic residue [active] 155864003710 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 155864003711 ORF11CD3 domain; Region: ORF11CD3; pfam10549 155864003712 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 155864003713 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 155864003714 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 155864003715 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 155864003716 active site 155864003717 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 155864003718 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 155864003719 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 155864003720 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 155864003721 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 155864003722 Phage capsid family; Region: Phage_capsid; pfam05065 155864003723 Phage-related protein [Function unknown]; Region: COG4695 155864003724 Phage-related protein [Function unknown]; Region: COG4695 155864003725 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 155864003726 Cryptic prophage CP-933M; includes one copy of the 60 bp direct repeat that flanks the prophage; O-island #44; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655; O-island #44 155864003727 Bacteriophage head-tail adaptor [General function prediction only]; Region: COG5614 155864003728 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 155864003729 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 155864003730 Immunoglobulin I-set domain; Region: I-set; pfam07679 155864003731 Immunoglobulin domain; Region: Ig_2; pfam13895 155864003732 Phage tail assembly chaperone; Region: Phage_TAC; pfam06222 155864003733 Protein of unknown function (DUF4035); Region: DUF4035; pfam13227 155864003734 Phage-related minor tail protein [Function unknown]; Region: COG5281 155864003735 tape measure domain; Region: tape_meas_nterm; TIGR02675 155864003736 Phage-related minor tail protein [Function unknown]; Region: COG5281 155864003737 Phage-related protein [Function unknown]; Region: gp18; COG4672 155864003738 Phage minor tail protein L; Region: Phage_tail_L; cl01908 155864003739 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 155864003740 MPN+ (JAMM) motif; other site 155864003741 Zinc-binding site [ion binding]; other site 155864003742 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 155864003743 NlpC/P60 family; Region: NLPC_P60; cl17555 155864003744 Phage-related protein, tail component [Function unknown]; Region: COG4723 155864003745 Phage-related protein, tail component [Function unknown]; Region: COG4733 155864003746 Phage-related protein, tail component [Function unknown]; Region: COG4733 155864003747 Putative phage tail protein; Region: Phage-tail_3; pfam13550 155864003748 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 155864003749 Interdomain contacts; other site 155864003750 Cytokine receptor motif; other site 155864003751 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 155864003752 Fibronectin type III protein; Region: DUF3672; pfam12421 155864003753 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 155864003754 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 155864003755 Cryptic prophage CP-933M; includes one copy of the 60 bp direct repeat that flanks the prophage 155864003756 O-island #44; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864003757 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 155864003758 EspF protein repeat; Region: EspF; pfam04806 155864003759 EspF protein repeat; Region: EspF; pfam04806 155864003760 EspF protein repeat; Region: EspF; pfam04806 155864003761 EspF protein repeat; Region: EspF; pfam04806 155864003762 EspF protein repeat; Region: EspF; pfam04806 155864003763 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 155864003764 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 155864003765 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 155864003766 hydrogenase 1 large subunit; Provisional; Region: PRK10170 155864003767 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 155864003768 hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171 155864003769 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 155864003770 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 155864003771 putative substrate-binding site; other site 155864003772 nickel binding site [ion binding]; other site 155864003773 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 155864003774 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 155864003775 cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035 155864003776 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 155864003777 cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028 155864003778 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 155864003779 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 155864003780 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 155864003781 catalytic core [active] 155864003782 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 155864003783 cryptic autophosphorylating protein tyrosine kinase Etk; Provisional; Region: PRK09841 155864003784 Chain length determinant protein; Region: Wzz; pfam02706 155864003785 Chain length determinant protein; Region: Wzz; cl15801 155864003786 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 155864003787 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 155864003788 Nucleotide binding site [chemical binding]; other site 155864003789 Low molecular weight phosphatase family; Region: LMWPc; cd00115 155864003790 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 155864003791 active site 155864003792 polysaccharide export protein Wza; Provisional; Region: PRK15078 155864003793 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 155864003794 SLBB domain; Region: SLBB; pfam10531 155864003795 SLBB domain; Region: SLBB; pfam10531 155864003796 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 155864003797 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 155864003798 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 155864003799 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 155864003800 DNA-binding site [nucleotide binding]; DNA binding site 155864003801 RNA-binding motif; other site 155864003802 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 155864003803 DNA-binding site [nucleotide binding]; DNA binding site 155864003804 RNA-binding motif; other site 155864003805 cold shock gene; Provisional; Region: PRK09891 155864003806 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 155864003807 4Fe-4S binding domain; Region: Fer4_5; pfam12801 155864003808 4Fe-4S binding domain; Region: Fer4_5; pfam12801 155864003809 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 155864003810 hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466 155864003811 HAMP domain; Region: HAMP; pfam00672 155864003812 dimerization interface [polypeptide binding]; other site 155864003813 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 155864003814 dimer interface [polypeptide binding]; other site 155864003815 phosphorylation site [posttranslational modification] 155864003816 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 155864003817 ATP binding site [chemical binding]; other site 155864003818 Mg2+ binding site [ion binding]; other site 155864003819 G-X-G motif; other site 155864003820 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 155864003821 active site 155864003822 phosphorylation site [posttranslational modification] 155864003823 intermolecular recognition site; other site 155864003824 dimerization interface [polypeptide binding]; other site 155864003825 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 155864003826 putative binding surface; other site 155864003827 active site 155864003828 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 155864003829 TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306 155864003830 putative ligand binding site [chemical binding]; other site 155864003831 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 155864003832 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 155864003833 active site 155864003834 phosphorylation site [posttranslational modification] 155864003835 intermolecular recognition site; other site 155864003836 dimerization interface [polypeptide binding]; other site 155864003837 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 155864003838 DNA binding site [nucleotide binding] 155864003839 trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032 155864003840 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 155864003841 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 155864003842 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 155864003843 molybdopterin cofactor binding site [chemical binding]; other site 155864003844 substrate binding site [chemical binding]; other site 155864003845 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 155864003846 molybdopterin cofactor binding site; other site 155864003847 chaperone protein TorD; Validated; Region: torD; PRK04976 155864003848 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 155864003849 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 155864003850 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 155864003851 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 155864003852 HSP70 interaction site [polypeptide binding]; other site 155864003853 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 155864003854 substrate binding site [polypeptide binding]; other site 155864003855 dimer interface [polypeptide binding]; other site 155864003856 hypothetical protein; Provisional; Region: PRK09784 155864003857 hypothetical protein; Provisional; Region: PRK09784 155864003858 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 155864003859 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 155864003860 catalytic core [active] 155864003861 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 155864003862 hypothetical protein; Provisional; Region: PRK10174 155864003863 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 155864003864 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 155864003865 Prophage BP-933W; includes one copy of the 7 bp direct repeat that flanks the prophage 155864003866 O-island #45; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864003867 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 155864003868 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 155864003869 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 155864003870 Int/Topo IB signature motif; other site 155864003871 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 155864003872 The ASCH domain adopts a beta-barrel fold similar to that of the PUA domain; Region: ASCH; smart01022 155864003873 Protein of unknown function (DUF551); Region: DUF551; pfam04448 155864003874 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 155864003875 O-island #45; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655; Prophage BP-933W; includes one copy of the 7 bp direct repeat that flanks the prophage 155864003876 Protein of unknown function (DUF1382); Region: DUF1382; pfam07131 155864003877 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 155864003878 phage recombination protein Bet; Region: bet_lambda; TIGR01913 155864003879 Host-nuclease inhibitor protein Gam; Region: Gam; pfam06064 155864003880 Bacteriophage lambda Kil protein; Region: Lambda_Kil; pfam06301 155864003881 Protein of unknown function (DUF2528); Region: DUF2528; pfam10800 155864003882 Catalytic domain of Protein Kinases; Region: PKc; cd00180 155864003883 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 155864003884 active site 155864003885 ATP binding site [chemical binding]; other site 155864003886 substrate binding site [chemical binding]; other site 155864003887 activation loop (A-loop); other site 155864003888 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cl17280 155864003889 Protein of unknown function (DUF3024); Region: DUF3024; pfam11225 155864003890 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 155864003891 non-specific DNA binding site [nucleotide binding]; other site 155864003892 salt bridge; other site 155864003893 sequence-specific DNA binding site [nucleotide binding]; other site 155864003894 Predicted transcriptional regulator [Transcription]; Region: COG2932 155864003895 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 155864003896 Catalytic site [active] 155864003897 Helix-turn-helix domain; Region: HTH_17; pfam12728 155864003898 Bacteriophage CII protein; Region: Phage_CII; pfam05269 155864003899 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 155864003900 Replication protein P; Region: Phage_lambda_P; pfam06992 155864003901 O-island #45; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655; Prophage BP-933W; includes one copy of the 7 bp direct repeat that flanks the prophage 155864003902 NinB protein; Region: NinB; pfam05772 155864003903 phage N-6-adenine-methyltransferase; Region: phage_N6A_met; TIGR01712 155864003904 P63C domain; Region: P63C; pfam10546 155864003905 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646 155864003906 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 155864003907 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 155864003908 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 155864003909 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 155864003910 Ribosome inactivating protein; Region: RIP; pfam00161 155864003911 Shiga-like toxin beta subunit; Region: SLT_beta; pfam02258 155864003912 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 155864003913 Domain of unknown function (DUF303); Region: DUF303; pfam03629 155864003914 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 155864003915 Protein of unknown function (DUF826); Region: DUF826; pfam05696 155864003916 O-island #45; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655; Prophage BP-933W; includes one copy of the 7 bp direct repeat that flanks the prophage 155864003917 Lysis protein S; Region: Lysis_S; pfam04971 155864003918 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 155864003919 catalytic residues [active] 155864003920 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 155864003921 ORF11CD3 domain; Region: ORF11CD3; pfam10549 155864003922 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 155864003923 Bor protein; Region: Lambda_Bor; pfam06291 155864003924 large terminase protein; Provisional; Region: 17; PHA02533 155864003925 large terminase protein; Provisional; Region: 17; PHA02533 155864003926 Protein of unknown function (DUF4043); Region: DUF4043; pfam13252 155864003927 O-island #45; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655; Prophage BP-933W; includes one copy of the 7 bp direct repeat that flanks the prophage 155864003928 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 155864003929 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 155864003930 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 155864003931 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 155864003932 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 155864003933 Phage-related protein, tail component [Function unknown]; Region: COG4733 155864003934 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 155864003935 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 155864003936 O-island #45; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655; Prophage BP-933W; includes one copy of the 7 bp direct repeat that flanks the prophage 155864003937 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483 155864003938 O-island #45; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864003939 Prophage BP-933W; includes one copy of the 7 bp direct repeat that flanks the prophage 155864003940 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 155864003941 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 155864003942 Protein of unknown function (DUF551); Region: DUF551; pfam04448 155864003943 Phage anti-repressor protein [Transcription]; Region: COG3561 155864003944 P22AR C-terminal domain; Region: P22_AR_C; pfam10548 155864003945 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 155864003946 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 155864003947 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 155864003948 putative FMN binding site [chemical binding]; other site 155864003949 pyrimidine utilization protein D; Region: RutD; TIGR03611 155864003950 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 155864003951 homotrimer interaction site [polypeptide binding]; other site 155864003952 putative active site [active] 155864003953 Isochorismatase family; Region: Isochorismatase; pfam00857 155864003954 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 155864003955 catalytic triad [active] 155864003956 conserved cis-peptide bond; other site 155864003957 pyrimidine utilization protein A; Region: RutA; TIGR03612 155864003958 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 155864003959 active site 155864003960 dimer interface [polypeptide binding]; other site 155864003961 non-prolyl cis peptide bond; other site 155864003962 insertion regions; other site 155864003963 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 155864003964 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 155864003965 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 155864003966 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 155864003967 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 155864003968 Predicted transcriptional regulator [Transcription]; Region: COG3905 155864003969 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 155864003970 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 155864003971 Glutamate binding site [chemical binding]; other site 155864003972 NAD binding site [chemical binding]; other site 155864003973 catalytic residues [active] 155864003974 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 155864003975 Na binding site [ion binding]; other site 155864003976 O-island #46; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864003977 FTR1 family protein; Region: TIGR00145 155864003978 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 155864003979 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 155864003980 Imelysin; Region: Peptidase_M75; pfam09375 155864003981 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 155864003982 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 155864003983 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 155864003984 hypothetical protein; Provisional; Region: PRK10536 155864003985 putative PGA biosynthesis protein; Provisional; Region: pgaD; PRK14585 155864003986 N-glycosyltransferase; Provisional; Region: PRK11204 155864003987 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 155864003988 DXD motif; other site 155864003989 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 155864003990 outer membrane N-deacetylase; Provisional; Region: pgaB; PRK14582 155864003991 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 155864003992 putative active site [active] 155864003993 putative metal binding site [ion binding]; other site 155864003994 outer membrane protein PgaA; Provisional; Region: pgaA; PRK10049 155864003995 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 155864003996 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 155864003997 metal binding site [ion binding]; metal-binding site 155864003998 active site 155864003999 I-site; other site 155864004000 O-island #47; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864004001 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 155864004002 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 155864004003 O-island #47; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864004004 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 155864004005 DNA binding site [nucleotide binding] 155864004006 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 155864004007 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 155864004008 NADP binding site [chemical binding]; other site 155864004009 homodimer interface [polypeptide binding]; other site 155864004010 active site 155864004011 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 155864004012 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 155864004013 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 155864004014 Fimbrial protein; Region: Fimbrial; cl01416 155864004015 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 155864004016 PapC N-terminal domain; Region: PapC_N; pfam13954 155864004017 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 155864004018 PapC C-terminal domain; Region: PapC_C; pfam13953 155864004019 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 155864004020 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 155864004021 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 155864004022 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 155864004023 O-island #47; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864004024 haemagglutination activity domain; Region: Haemagg_act; pfam05860 155864004025 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 155864004026 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 155864004027 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 155864004028 Phosphopantetheinyl transferase (holo-ACP synthase) [Lipid metabolism]; Region: AcpS; COG0736 155864004029 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 155864004030 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 155864004031 NAD(P) binding site [chemical binding]; other site 155864004032 active site 155864004033 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 155864004034 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 155864004035 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 155864004036 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 155864004037 O-island #47; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864004038 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 155864004039 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 155864004040 dimer interface [polypeptide binding]; other site 155864004041 active site 155864004042 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 155864004043 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 155864004044 active site 155864004045 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 155864004046 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 155864004047 active site 155864004048 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 155864004049 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 155864004050 Walker A/P-loop; other site 155864004051 ATP binding site [chemical binding]; other site 155864004052 Q-loop/lid; other site 155864004053 ABC transporter signature motif; other site 155864004054 Walker B; other site 155864004055 D-loop; other site 155864004056 H-loop/switch region; other site 155864004057 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 155864004058 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 155864004059 FtsX-like permease family; Region: FtsX; pfam02687 155864004060 O-island #47; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864004061 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 155864004062 O-island #48; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864004063 integrase; Provisional; Region: PRK09692 155864004064 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 155864004065 active site 155864004066 Int/Topo IB signature motif; other site 155864004067 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 155864004068 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 155864004069 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 155864004070 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 155864004071 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 155864004072 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 155864004073 similar to hypothetical protein; No significant matches 155864004074 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 155864004075 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 155864004076 O-island #48; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864004077 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4951 155864004078 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 155864004079 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 155864004080 ATP binding site [chemical binding]; other site 155864004081 putative Mg++ binding site [ion binding]; other site 155864004082 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 155864004083 nucleotide binding region [chemical binding]; other site 155864004084 ATP-binding site [chemical binding]; other site 155864004085 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 155864004086 homodimer interface [polypeptide binding]; other site 155864004087 putative GKAP docking site [polypeptide binding]; other site 155864004088 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 155864004089 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 155864004090 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 155864004091 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 155864004092 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 155864004093 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 155864004094 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 155864004095 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 155864004096 DNA-binding interface [nucleotide binding]; DNA binding site 155864004097 Helix-turn-helix domain; Region: HTH_38; pfam13936 155864004098 putative transposase OrfB; Reviewed; Region: PHA02517 155864004099 Integrase core domain; Region: rve; pfam00665 155864004100 Integrase core domain; Region: rve_3; pfam13683 155864004101 Enterobacterial TraT complement resistance protein; Region: TraT; pfam05818 155864004102 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 155864004103 similar to hypothetical protein; No significant matches 155864004104 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 155864004105 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 155864004106 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 155864004107 Sulfatase; Region: Sulfatase; pfam00884 155864004108 O-island #48; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864004109 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 155864004110 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 155864004111 alpha-gamma subunit interface [polypeptide binding]; other site 155864004112 beta-gamma subunit interface [polypeptide binding]; other site 155864004113 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 155864004114 gamma-beta subunit interface [polypeptide binding]; other site 155864004115 alpha-beta subunit interface [polypeptide binding]; other site 155864004116 urease subunit alpha; Reviewed; Region: ureC; PRK13207 155864004117 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 155864004118 subunit interactions [polypeptide binding]; other site 155864004119 active site 155864004120 flap region; other site 155864004121 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 155864004122 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 155864004123 dimer interface [polypeptide binding]; other site 155864004124 catalytic residues [active] 155864004125 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 155864004126 UreF; Region: UreF; pfam01730 155864004127 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 155864004128 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 155864004129 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 155864004130 Transposase; Region: HTH_Tnp_1; pfam01527 155864004131 conjugal transfer surface exclusion protein TraT; Provisional; Region: PRK13731 155864004132 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 155864004133 Hok/gef family; Region: HOK_GEF; pfam01848 155864004134 O-island #48; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864004135 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 155864004136 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 155864004137 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 155864004138 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 155864004139 Transposase; Region: HTH_Tnp_1; pfam01527 155864004140 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 155864004141 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 155864004142 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 155864004143 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 155864004144 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 155864004145 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 155864004146 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 155864004147 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 155864004148 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 155864004149 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 155864004150 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 155864004151 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 155864004152 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 155864004153 Predicted transcriptional regulator [Transcription]; Region: COG2378 155864004154 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 155864004155 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 155864004156 Protein of unknown function (DUF2983); Region: DUF2983; pfam11202 155864004157 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 155864004158 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 155864004159 active site 155864004160 Protein of unknown function (DUF3706); Region: DUF3706; pfam12500 155864004161 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 155864004162 O-island #48; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864004163 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 155864004164 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 155864004165 putative metal binding site [ion binding]; other site 155864004166 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 155864004167 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 155864004168 putative metal binding site [ion binding]; other site 155864004169 Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110 155864004170 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 155864004171 putative metal binding site [ion binding]; other site 155864004172 tellurite resistance protein terB; Region: terB; cd07176 155864004173 putative metal binding site [ion binding]; other site 155864004174 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 155864004175 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 155864004176 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 155864004177 putative metal binding site [ion binding]; other site 155864004178 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 155864004179 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 155864004180 putative metal binding site [ion binding]; other site 155864004181 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 155864004182 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 155864004183 putative metal binding site [ion binding]; other site 155864004184 bifunctional enterobactin receptor/adhesin protein; Provisional; Region: PRK13486 155864004185 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 155864004186 N-terminal plug; other site 155864004187 ligand-binding site [chemical binding]; other site 155864004188 similar to hypothetical protein; No significant matches 155864004189 O-island #48; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864004190 bifunctional enterobactin receptor/adhesin protein; Provisional; Region: PRK13486 155864004191 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 155864004192 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 155864004193 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 155864004194 homodimer interface [polypeptide binding]; other site 155864004195 TDP-binding site; other site 155864004196 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 155864004197 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 155864004198 Helix-turn-helix domain; Region: HTH_39; pfam14090 155864004199 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 155864004200 putative transposase OrfB; Reviewed; Region: PHA02517 155864004201 HTH-like domain; Region: HTH_21; pfam13276 155864004202 Integrase core domain; Region: rve; pfam00665 155864004203 Integrase core domain; Region: rve_3; pfam13683 155864004204 Transposase; Region: HTH_Tnp_1; cl17663 155864004205 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 155864004206 O-island #48; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864004207 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 155864004208 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 155864004209 adhesin HecA family 20-residue repeat (two copies); Region: fil_hemag_20aa; TIGR01731 155864004210 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 155864004211 Part of AAA domain; Region: AAA_19; pfam13245 155864004212 AAA domain; Region: AAA_12; pfam13087 155864004213 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 155864004214 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 155864004215 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 155864004216 Active Sites [active] 155864004217 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 155864004218 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 155864004219 ParB-like nuclease domain; Region: ParB; smart00470 155864004220 Integrase core domain; Region: rve_3; cl15866 155864004221 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 155864004222 Transposase; Region: HTH_Tnp_1; pfam01527 155864004223 Predicted GTPase [General function prediction only]; Region: COG3596 155864004224 YfjP GTPase; Region: YfjP; cd11383 155864004225 G1 box; other site 155864004226 GTP/Mg2+ binding site [chemical binding]; other site 155864004227 Switch I region; other site 155864004228 G2 box; other site 155864004229 Switch II region; other site 155864004230 G3 box; other site 155864004231 G4 box; other site 155864004232 G5 box; other site 155864004233 O-island #48; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864004234 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 155864004235 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 155864004236 hypothetical protein; Provisional; Region: PRK09945 155864004237 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 155864004238 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 155864004239 Autotransporter beta-domain; Region: Autotransporter; smart00869 155864004240 hypothetical protein; Provisional; Region: PRK09866 155864004241 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 155864004242 G1 box; other site 155864004243 GTP/Mg2+ binding site [chemical binding]; other site 155864004244 G2 box; other site 155864004245 Switch I region; other site 155864004246 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 155864004247 G3 box; other site 155864004248 Switch II region; other site 155864004249 GTP/Mg2+ binding site [chemical binding]; other site 155864004250 G4 box; other site 155864004251 G5 box; other site 155864004252 YjcZ-like protein; Region: YjcZ; pfam13990 155864004253 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 155864004254 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 155864004255 nucleophile elbow; other site 155864004256 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 155864004257 Domain of unknown function (DUF932); Region: DUF932; pfam06067 155864004258 Antirestriction protein; Region: Antirestrict; pfam03230 155864004259 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 155864004260 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 155864004261 MPN+ (JAMM) motif; other site 155864004262 Zinc-binding site [ion binding]; other site 155864004263 O-island #48; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864004264 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 155864004265 putative transposase OrfB; Reviewed; Region: PHA02517 155864004266 HTH-like domain; Region: HTH_21; pfam13276 155864004267 Integrase core domain; Region: rve; pfam00665 155864004268 Integrase core domain; Region: rve_3; pfam13683 155864004269 Transposase; Region: HTH_Tnp_1; cl17663 155864004270 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 155864004271 Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117 155864004272 Methyltransferase domain; Region: Methyltransf_27; pfam13708 155864004273 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 155864004274 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 155864004275 putative ligand binding site [chemical binding]; other site 155864004276 NAD binding site [chemical binding]; other site 155864004277 dimerization interface [polypeptide binding]; other site 155864004278 catalytic site [active] 155864004279 putative hydrolase; Validated; Region: PRK09248 155864004280 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 155864004281 active site 155864004282 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 155864004283 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 155864004284 curli production assembly/transport protein CsgG; Provisional; Region: PRK15184 155864004285 curli assembly protein CsgF; Provisional; Region: PRK10050 155864004286 curli assembly protein CsgE; Provisional; Region: PRK10386 155864004287 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 155864004288 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 155864004289 DNA binding residues [nucleotide binding] 155864004290 dimerization interface [polypeptide binding]; other site 155864004291 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 155864004292 Curlin associated repeat; Region: Curlin_rpt; pfam07012 155864004293 Curlin associated repeat; Region: Curlin_rpt; pfam07012 155864004294 major curlin subunit; Provisional; Region: csgA; PRK10051 155864004295 Curlin associated repeat; Region: Curlin_rpt; pfam07012 155864004296 Curlin associated repeat; Region: Curlin_rpt; pfam07012 155864004297 curli assembly protein CsgC; Provisional; Region: csgC; PRK10102 155864004298 Fimbrial protein; Region: Fimbrial; cl01416 155864004299 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 155864004300 putative ADP-ribose binding site [chemical binding]; other site 155864004301 putative active site [active] 155864004302 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 155864004303 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 155864004304 putative active site [active] 155864004305 catalytic site [active] 155864004306 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 155864004307 putative active site [active] 155864004308 catalytic site [active] 155864004309 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 155864004310 Acyltransferase family; Region: Acyl_transf_3; pfam01757 155864004311 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 155864004312 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349 155864004313 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 155864004314 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 155864004315 Ligand binding site; other site 155864004316 DXD motif; other site 155864004317 lipoprotein; Provisional; Region: PRK10175 155864004318 secY/secA suppressor protein; Provisional; Region: PRK11467 155864004319 drug efflux system protein MdtG; Provisional; Region: PRK09874 155864004320 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864004321 putative substrate translocation pore; other site 155864004322 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 155864004323 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 155864004324 putative acyl-acceptor binding pocket; other site 155864004325 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 155864004326 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 155864004327 active site residue [active] 155864004328 hypothetical protein; Provisional; Region: PRK03757 155864004329 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 155864004330 Protein of unknown function (DUF2770); Region: DUF2770; pfam10968 155864004331 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 155864004332 hydroxyglutarate oxidase; Provisional; Region: PRK11728 155864004333 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 155864004334 DNA damage-inducible protein I; Provisional; Region: PRK10597 155864004335 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 155864004336 active site 155864004337 substrate binding pocket [chemical binding]; other site 155864004338 dimer interface [polypeptide binding]; other site 155864004339 lipoprotein; Provisional; Region: PRK10598 155864004340 glutaredoxin 2; Provisional; Region: PRK10387 155864004341 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 155864004342 C-terminal domain interface [polypeptide binding]; other site 155864004343 GSH binding site (G-site) [chemical binding]; other site 155864004344 catalytic residues [active] 155864004345 putative dimer interface [polypeptide binding]; other site 155864004346 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 155864004347 N-terminal domain interface [polypeptide binding]; other site 155864004348 multidrug resistance protein MdtH; Provisional; Region: PRK11646 155864004349 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864004350 putative substrate translocation pore; other site 155864004351 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 155864004352 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 155864004353 hypothetical protein; Provisional; Region: PRK11239 155864004354 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 155864004355 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 155864004356 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 155864004357 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 155864004358 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 155864004359 MviN-like protein; Region: MVIN; pfam03023 155864004360 flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459 155864004361 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 155864004362 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 155864004363 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 155864004364 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 155864004365 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 155864004366 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 155864004367 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 155864004368 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 155864004369 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 155864004370 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 155864004371 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 155864004372 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 155864004373 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 155864004374 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 155864004375 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 155864004376 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 155864004377 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787 155864004378 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 155864004379 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 155864004380 O-island #49; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864004381 O-island #49; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864004382 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 155864004383 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 155864004384 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 155864004385 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 155864004386 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 155864004387 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 155864004388 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 155864004389 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 155864004390 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 155864004391 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 155864004392 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 155864004393 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 155864004394 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 155864004395 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 155864004396 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 155864004397 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 155864004398 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 155864004399 homodimer interface [polypeptide binding]; other site 155864004400 oligonucleotide binding site [chemical binding]; other site 155864004401 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 155864004402 Protein of unknown function (DUF2655); Region: DUF2655; pfam10848 155864004403 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 155864004404 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 155864004405 RNA binding surface [nucleotide binding]; other site 155864004406 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 155864004407 active site 155864004408 Maf-like protein; Region: Maf; pfam02545 155864004409 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 155864004410 active site 155864004411 dimer interface [polypeptide binding]; other site 155864004412 hypothetical protein; Provisional; Region: PRK11193 155864004413 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 155864004414 putative phosphate acyltransferase; Provisional; Region: PRK05331 155864004415 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 155864004416 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 155864004417 dimer interface [polypeptide binding]; other site 155864004418 active site 155864004419 CoA binding pocket [chemical binding]; other site 155864004420 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 155864004421 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 155864004422 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 155864004423 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 155864004424 NAD(P) binding site [chemical binding]; other site 155864004425 homotetramer interface [polypeptide binding]; other site 155864004426 homodimer interface [polypeptide binding]; other site 155864004427 active site 155864004428 acyl carrier protein; Provisional; Region: acpP; PRK00982 155864004429 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 155864004430 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 155864004431 dimer interface [polypeptide binding]; other site 155864004432 active site 155864004433 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 155864004434 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 155864004435 pyridoxal 5'-phosphate binding site [chemical binding]; other site 155864004436 catalytic residue [active] 155864004437 conserved hypothetical protein, YceG family; Region: TIGR00247 155864004438 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 155864004439 dimerization interface [polypeptide binding]; other site 155864004440 thymidylate kinase; Validated; Region: tmk; PRK00698 155864004441 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 155864004442 TMP-binding site; other site 155864004443 ATP-binding site [chemical binding]; other site 155864004444 DNA polymerase III subunit delta'; Validated; Region: PRK07993 155864004445 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 155864004446 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 155864004447 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 155864004448 active site 155864004449 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 155864004450 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 155864004451 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 155864004452 active site turn [active] 155864004453 phosphorylation site [posttranslational modification] 155864004454 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 155864004455 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 155864004456 N-terminal plug; other site 155864004457 ligand-binding site [chemical binding]; other site 155864004458 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 155864004459 nucleotide binding site/active site [active] 155864004460 HIT family signature motif; other site 155864004461 catalytic residue [active] 155864004462 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 155864004463 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 155864004464 putative dimer interface [polypeptide binding]; other site 155864004465 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 155864004466 thiamine kinase; Region: ycfN_thiK; TIGR02721 155864004467 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 155864004468 active site 155864004469 substrate binding site [chemical binding]; other site 155864004470 ATP binding site [chemical binding]; other site 155864004471 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 155864004472 beta-hexosaminidase; Provisional; Region: PRK05337 155864004473 hypothetical protein; Provisional; Region: PRK04940 155864004474 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 155864004475 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 155864004476 hypothetical protein; Provisional; Region: PRK11280 155864004477 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 155864004478 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 155864004479 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 155864004480 L,D-transpeptidase; Provisional; Region: PRK10260 155864004481 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 155864004482 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 155864004483 transcription-repair coupling factor; Provisional; Region: PRK10689 155864004484 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 155864004485 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 155864004486 ATP binding site [chemical binding]; other site 155864004487 putative Mg++ binding site [ion binding]; other site 155864004488 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 155864004489 nucleotide binding region [chemical binding]; other site 155864004490 ATP-binding site [chemical binding]; other site 155864004491 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 155864004492 Predicted membrane protein [Function unknown]; Region: COG4763 155864004493 Acyltransferase family; Region: Acyl_transf_3; pfam01757 155864004494 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 155864004495 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 155864004496 FtsX-like permease family; Region: FtsX; pfam02687 155864004497 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 155864004498 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 155864004499 Walker A/P-loop; other site 155864004500 ATP binding site [chemical binding]; other site 155864004501 Q-loop/lid; other site 155864004502 ABC transporter signature motif; other site 155864004503 Walker B; other site 155864004504 D-loop; other site 155864004505 H-loop/switch region; other site 155864004506 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 155864004507 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 155864004508 FtsX-like permease family; Region: FtsX; pfam02687 155864004509 fructokinase; Reviewed; Region: PRK09557 155864004510 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 155864004511 nucleotide binding site [chemical binding]; other site 155864004512 NAD-dependent deacetylase; Provisional; Region: PRK00481 155864004513 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 155864004514 NAD+ binding site [chemical binding]; other site 155864004515 substrate binding site [chemical binding]; other site 155864004516 Zn binding site [ion binding]; other site 155864004517 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 155864004518 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 155864004519 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 155864004520 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 155864004521 dimer interface [polypeptide binding]; other site 155864004522 conserved gate region; other site 155864004523 putative PBP binding loops; other site 155864004524 ABC-ATPase subunit interface; other site 155864004525 O-island #50; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864004526 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 155864004527 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 155864004528 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 155864004529 dimer interface [polypeptide binding]; other site 155864004530 active site 155864004531 Int/Topo IB signature motif; other site 155864004532 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 155864004533 active site 155864004534 substrate binding site [chemical binding]; other site 155864004535 catalytic site [active] 155864004536 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 155864004537 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 155864004538 sequence-specific DNA binding site [nucleotide binding]; other site 155864004539 salt bridge; other site 155864004540 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 155864004541 Pyocin large subunit [General function prediction only]; Region: COG5529 155864004542 primosomal protein DnaI; Provisional; Region: PRK02854 155864004543 Protein of unknown function (DUF1627); Region: DUF1627; pfam07789 155864004544 Domain of unknown function (DUF4406); Region: DUF4406; pfam14359 155864004545 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 155864004546 O-island #50; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864004547 Protein of unknown function (DUF551); Region: DUF551; pfam04448 155864004548 Hok/gef family; Region: HOK_GEF; pfam01848 155864004549 Protein of unknown function (DUF968); Region: DUF968; pfam06147 155864004550 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 155864004551 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 155864004552 CAAX protease self-immunity; Region: Abi; pfam02517 155864004553 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 155864004554 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 155864004555 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 155864004556 Domain of unknown function (DUF303); Region: DUF303; pfam03629 155864004557 Lysis protein S; Region: Lysis_S; pfam04971 155864004558 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 155864004559 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 155864004560 catalytic residues [active] 155864004561 O-island #50; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864004562 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 155864004563 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 155864004564 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 155864004565 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 155864004566 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 155864004567 active site 155864004568 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 155864004569 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 155864004570 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 155864004571 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 155864004572 Phage capsid family; Region: Phage_capsid; pfam05065 155864004573 Phage-related protein [Function unknown]; Region: COG4695 155864004574 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 155864004575 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 155864004576 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 155864004577 zinc binding site [ion binding]; other site 155864004578 O-island #50; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864004579 Bacteriophage head-tail adaptor [General function prediction only]; Region: COG5614 155864004580 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 155864004581 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 155864004582 Immunoglobulin domain; Region: Ig_3; pfam13927 155864004583 Phage tail assembly chaperone; Region: Phage_TAC; pfam06222 155864004584 Protein of unknown function (DUF4035); Region: DUF4035; pfam13227 155864004585 Phage-related minor tail protein [Function unknown]; Region: COG5281 155864004586 tape measure domain; Region: tape_meas_nterm; TIGR02675 155864004587 Phage-related protein [Function unknown]; Region: gp18; COG4672 155864004588 Prophage antirepressor [Transcription]; Region: COG3617 155864004589 BRO family, N-terminal domain; Region: Bro-N; smart01040 155864004590 Phage anti-repressor protein [Transcription]; Region: COG3561 155864004591 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 155864004592 MPN+ (JAMM) motif; other site 155864004593 Zinc-binding site [ion binding]; other site 155864004594 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 155864004595 NlpC/P60 family; Region: NLPC_P60; cl17555 155864004596 Phage-related protein, tail component [Function unknown]; Region: COG4723 155864004597 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 155864004598 SopA-like central domain; Region: SopA; pfam13981 155864004599 SopA-like catalytic domain; Region: SopA_C; pfam13979 155864004600 O-island #50; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864004601 IS2 transposase TnpB; Reviewed; Region: PRK09409 155864004602 HTH-like domain; Region: HTH_21; pfam13276 155864004603 Integrase core domain; Region: rve; pfam00665 155864004604 Integrase core domain; Region: rve_3; pfam13683 155864004605 Transposase; Region: HTH_Tnp_1; cl17663 155864004606 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 155864004607 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 155864004608 type III secretion protein GogB; Provisional; Region: PRK15386 155864004609 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 155864004610 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 155864004611 dimer interface [polypeptide binding]; other site 155864004612 conserved gate region; other site 155864004613 putative PBP binding loops; other site 155864004614 ABC-ATPase subunit interface; other site 155864004615 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 155864004616 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 155864004617 Walker A/P-loop; other site 155864004618 ATP binding site [chemical binding]; other site 155864004619 Q-loop/lid; other site 155864004620 ABC transporter signature motif; other site 155864004621 Walker B; other site 155864004622 D-loop; other site 155864004623 H-loop/switch region; other site 155864004624 TOBE domain; Region: TOBE_2; pfam08402 155864004625 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 155864004626 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 155864004627 metal binding site [ion binding]; metal-binding site 155864004628 dimer interface [polypeptide binding]; other site 155864004629 Uncharacterized conserved protein [Function unknown]; Region: COG2850 155864004630 Cupin-like domain; Region: Cupin_8; pfam13621 155864004631 O-island #51; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864004632 Cryptic prophage CP-933C; includes one copy of the 21 bp direct repeat that flanks the prophage 155864004633 integrase; Provisional; Region: PRK09692 155864004634 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 155864004635 active site 155864004636 Int/Topo IB signature motif; other site 155864004637 Domain of unknown function (DUF927); Region: DUF927; cl12098 155864004638 Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519 155864004639 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 155864004640 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 155864004641 ssDNA binding site [nucleotide binding]; other site 155864004642 dimer interface [polypeptide binding]; other site 155864004643 tetramer (dimer of dimers) interface [polypeptide binding]; other site 155864004644 O-island #51; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864004645 Cryptic prophage CP-933C; includes one copy of the 21 bp direct repeat that flanks the prophage 155864004646 Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653 155864004647 Phage capsid family; Region: Phage_capsid; pfam05065 155864004648 Phage head maturation protease [General function prediction only]; Region: COG3740 155864004649 Phage-related protein [Function unknown]; Region: COG4695 155864004650 Phage portal protein; Region: Phage_portal; pfam04860 155864004651 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 155864004652 oligomerization interface [polypeptide binding]; other site 155864004653 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 155864004654 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 155864004655 active site 155864004656 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: COG3747 155864004657 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 155864004658 sensor protein PhoQ; Provisional; Region: PRK10815 155864004659 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 155864004660 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 155864004661 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 155864004662 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 155864004663 ATP binding site [chemical binding]; other site 155864004664 Mg2+ binding site [ion binding]; other site 155864004665 G-X-G motif; other site 155864004666 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 155864004667 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 155864004668 active site 155864004669 phosphorylation site [posttranslational modification] 155864004670 intermolecular recognition site; other site 155864004671 dimerization interface [polypeptide binding]; other site 155864004672 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 155864004673 DNA binding site [nucleotide binding] 155864004674 adenylosuccinate lyase; Provisional; Region: PRK09285 155864004675 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 155864004676 tetramer interface [polypeptide binding]; other site 155864004677 active site 155864004678 putative lysogenization regulator; Reviewed; Region: PRK00218 155864004679 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 155864004680 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 155864004681 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 155864004682 nudix motif; other site 155864004683 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 155864004684 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 155864004685 probable active site [active] 155864004686 isocitrate dehydrogenase; Validated; Region: PRK07362 155864004687 isocitrate dehydrogenase; Reviewed; Region: PRK07006 155864004688 O-island #52; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864004689 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 155864004690 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 155864004691 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 155864004692 dimer interface [polypeptide binding]; other site 155864004693 active site 155864004694 Int/Topo IB signature motif; other site 155864004695 Bacteriophage replication protein O; Region: Phage_rep_O; cl04545 155864004696 Replication protein P; Region: Phage_lambda_P; pfam06992 155864004697 multidrug efflux protein; Reviewed; Region: emrE; PRK09541 155864004698 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 155864004699 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 155864004700 catalytic residues [active] 155864004701 catalytic nucleophile [active] 155864004702 Recombinase; Region: Recombinase; pfam07508 155864004703 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 155864004704 O-island #52; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864004705 hypothetical protein; Provisional; Region: PRK09741 155864004706 endodeoxyribonuclease RUS; Reviewed; Region: PRK09786 155864004707 Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323 155864004708 The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes. But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736 155864004709 N-acetyl-D-glucosamine binding site [chemical binding]; other site 155864004710 catalytic residue [active] 155864004711 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 155864004712 Bor protein; Region: Lambda_Bor; pfam06291 155864004713 Protein of unknown function (DUF1398); Region: DUF1398; pfam07166 155864004714 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 155864004715 Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471 155864004716 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 155864004717 gpW; Region: gpW; pfam02831 155864004718 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 155864004719 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 155864004720 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 155864004721 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 155864004722 tandem repeat interface [polypeptide binding]; other site 155864004723 oligomer interface [polypeptide binding]; other site 155864004724 active site residues [active] 155864004725 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 155864004726 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 155864004727 DNA packaging protein FI; Region: Packaging_FI; pfam14000 155864004728 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 155864004729 O-island #52; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864004730 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 155864004731 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 155864004732 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 155864004733 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 155864004734 phage minor tail protein G; Region: phage_lambda_G; TIGR01674 155864004735 Minor tail protein T; Region: Phage_tail_T; pfam06223 155864004736 Phage-related minor tail protein [Function unknown]; Region: COG5281 155864004737 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 155864004738 O-island #52; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864004739 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 155864004740 oligomerization interface [polypeptide binding]; other site 155864004741 Bacteriophage head-tail adaptor [General function prediction only]; Region: COG5614 155864004742 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 155864004743 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 155864004744 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 155864004745 Immunoglobulin I-set domain; Region: I-set; pfam07679 155864004746 Immunoglobulin domain; Region: Ig_2; pfam13895 155864004747 Phage tail assembly chaperone; Region: Phage_TAC; pfam06222 155864004748 Protein of unknown function (DUF4035); Region: DUF4035; pfam13227 155864004749 Phage-related minor tail protein [Function unknown]; Region: COG5281 155864004750 tape measure domain; Region: tape_meas_nterm; TIGR02675 155864004751 Tail length tape measure protein; Region: Phage_HK97_TLTM; pfam06120 155864004752 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 155864004753 Phage-related protein [Function unknown]; Region: gp18; COG4672 155864004754 O-island #52; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864004755 Phage-related protein, tail component [Function unknown]; Region: COG4733 155864004756 Putative phage tail protein; Region: Phage-tail_3; pfam13550 155864004757 Phage-related protein, tail component [Function unknown]; Region: COG4733 155864004758 Putative phage tail protein; Region: Phage-tail_3; pfam13550 155864004759 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 155864004760 Interdomain contacts; other site 155864004761 Cytokine receptor motif; other site 155864004762 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 155864004763 Fibronectin type III protein; Region: DUF3672; pfam12421 155864004764 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 155864004765 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 155864004766 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 155864004767 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 155864004768 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 155864004769 Phage Tail Collar Domain; Region: Collar; pfam07484 155864004770 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 155864004771 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 155864004772 dimanganese center [ion binding]; other site 155864004773 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 155864004774 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 155864004775 dimerization interface [polypeptide binding]; other site 155864004776 metal binding site [ion binding]; metal-binding site 155864004777 General stress protein [General function prediction only]; Region: GsiB; COG3729 155864004778 O-island #52; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864004779 Methyltransferase domain; Region: Methyltransf_31; pfam13847 155864004780 Methyltransferase domain; Region: Methyltransf_12; pfam08242 155864004781 S-adenosylmethionine binding site [chemical binding]; other site 155864004782 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 155864004783 Transposase; Region: HTH_Tnp_1; pfam01527 155864004784 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 155864004785 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 155864004786 homodimer interface [polypeptide binding]; other site 155864004787 putative GKAP docking site [polypeptide binding]; other site 155864004788 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 155864004789 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 155864004790 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 155864004791 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 155864004792 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 155864004793 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 155864004794 TAP-like protein; Region: Abhydrolase_4; pfam08386 155864004795 outer membrane protease; Reviewed; Region: PRK10993 155864004796 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 155864004797 sequence-specific DNA binding site [nucleotide binding]; other site 155864004798 salt bridge; other site 155864004799 Transposase; Region: HTH_Tnp_1; cl17663 155864004800 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 155864004801 Integrase core domain; Region: rve; pfam00665 155864004802 Integrase core domain; Region: rve_3; pfam13683 155864004803 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 155864004804 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 155864004805 cell division inhibitor MinD; Provisional; Region: PRK10818 155864004806 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 155864004807 Switch I; other site 155864004808 Switch II; other site 155864004809 septum formation inhibitor; Reviewed; Region: minC; PRK03511 155864004810 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 155864004811 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 155864004812 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 155864004813 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 155864004814 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 155864004815 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 155864004816 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 155864004817 hypothetical protein; Provisional; Region: PRK10691 155864004818 hypothetical protein; Provisional; Region: PRK05170 155864004819 hemolysin E; Provisional; Region: hlyE; PRK11376 155864004820 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 155864004821 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 155864004822 Catalytic site [active] 155864004823 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 155864004824 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 155864004825 active site 155864004826 DNA binding site [nucleotide binding] 155864004827 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 155864004828 disulfide bond formation protein B; Provisional; Region: PRK01749 155864004829 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 155864004830 transmembrane helices; other site 155864004831 fatty acid metabolism regulator; Provisional; Region: PRK04984 155864004832 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 155864004833 DNA-binding site [nucleotide binding]; DNA binding site 155864004834 FadR C-terminal domain; Region: FadR_C; pfam07840 155864004835 SpoVR family protein; Provisional; Region: PRK11767 155864004836 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 155864004837 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 155864004838 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 155864004839 alanine racemase; Reviewed; Region: dadX; PRK03646 155864004840 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 155864004841 active site 155864004842 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 155864004843 substrate binding site [chemical binding]; other site 155864004844 catalytic residues [active] 155864004845 dimer interface [polypeptide binding]; other site 155864004846 O-island #53; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864004847 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 155864004848 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 155864004849 TrkA-C domain; Region: TrkA_C; pfam02080 155864004850 Transporter associated domain; Region: CorC_HlyC; smart01091 155864004851 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 155864004852 dimer interface [polypeptide binding]; other site 155864004853 catalytic triad [active] 155864004854 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 155864004855 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 155864004856 N-acetyl-D-glucosamine binding site [chemical binding]; other site 155864004857 catalytic residue [active] 155864004858 O-island #54; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864004859 putative transposase OrfB; Reviewed; Region: PHA02517 155864004860 HTH-like domain; Region: HTH_21; pfam13276 155864004861 Integrase core domain; Region: rve; pfam00665 155864004862 Integrase core domain; Region: rve_3; pfam13683 155864004863 Transposase; Region: HTH_Tnp_1; cl17663 155864004864 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 155864004865 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 155864004866 Flagellar regulator YcgR; Region: YcgR; pfam07317 155864004867 PilZ domain; Region: PilZ; pfam07238 155864004868 hypothetical protein; Provisional; Region: PRK10457 155864004869 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 155864004870 N-terminal plug; other site 155864004871 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 155864004872 ligand-binding site [chemical binding]; other site 155864004873 O-island #55; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864004874 molybdenum transport protein ModD; Provisional; Region: PRK06096 155864004875 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 155864004876 dimerization interface [polypeptide binding]; other site 155864004877 active site 155864004878 O-island #55; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864004879 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 155864004880 S-adenosylmethionine binding site [chemical binding]; other site 155864004881 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 155864004882 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 155864004883 Walker A/P-loop; other site 155864004884 ATP binding site [chemical binding]; other site 155864004885 Q-loop/lid; other site 155864004886 ABC transporter signature motif; other site 155864004887 Walker B; other site 155864004888 D-loop; other site 155864004889 H-loop/switch region; other site 155864004890 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 155864004891 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 155864004892 ABC-ATPase subunit interface; other site 155864004893 dimer interface [polypeptide binding]; other site 155864004894 putative PBP binding regions; other site 155864004895 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 155864004896 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 155864004897 putative metal binding site [ion binding]; other site 155864004898 trehalase; Provisional; Region: treA; PRK13271 155864004899 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 155864004900 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3412 155864004901 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 155864004902 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 155864004903 dimerization domain swap beta strand [polypeptide binding]; other site 155864004904 regulatory protein interface [polypeptide binding]; other site 155864004905 active site 155864004906 regulatory phosphorylation site [posttranslational modification]; other site 155864004907 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 155864004908 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 155864004909 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 155864004910 dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005 155864004911 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 155864004912 Dak1 domain; Region: Dak1; pfam02733 155864004913 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 155864004914 O-island #56; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864004915 GTP-binding protein YchF; Reviewed; Region: PRK09601 155864004916 YchF GTPase; Region: YchF; cd01900 155864004917 G1 box; other site 155864004918 GTP/Mg2+ binding site [chemical binding]; other site 155864004919 Switch I region; other site 155864004920 G2 box; other site 155864004921 Switch II region; other site 155864004922 G3 box; other site 155864004923 G4 box; other site 155864004924 G5 box; other site 155864004925 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 155864004926 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 155864004927 putative active site [active] 155864004928 catalytic residue [active] 155864004929 hypothetical protein; Provisional; Region: PRK10692 155864004930 putative transporter; Provisional; Region: PRK11660 155864004931 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 155864004932 Sulfate transporter family; Region: Sulfate_transp; pfam00916 155864004933 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 155864004934 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 155864004935 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 155864004936 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 155864004937 active site 155864004938 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 155864004939 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 155864004940 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 155864004941 outer membrane lipoprotein LolB; Region: lolB; TIGR00548 155864004942 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 155864004943 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 155864004944 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 155864004945 tRNA; other site 155864004946 putative tRNA binding site [nucleotide binding]; other site 155864004947 putative NADP binding site [chemical binding]; other site 155864004948 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 155864004949 peptide chain release factor 1; Validated; Region: prfA; PRK00591 155864004950 This domain is found in peptide chain release factors; Region: PCRF; smart00937 155864004951 RF-1 domain; Region: RF-1; pfam00472 155864004952 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 155864004953 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 155864004954 hypothetical protein; Provisional; Region: PRK10278 155864004955 hypothetical protein; Provisional; Region: PRK10941 155864004956 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 155864004957 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 155864004958 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 155864004959 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 155864004960 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 155864004961 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 155864004962 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 155864004963 cation transport regulator; Reviewed; Region: chaB; PRK09582 155864004964 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 155864004965 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 155864004966 putative active site pocket [active] 155864004967 dimerization interface [polypeptide binding]; other site 155864004968 putative catalytic residue [active] 155864004969 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 155864004970 putative invasin; Provisional; Region: PRK10177 155864004971 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 155864004972 transcriptional regulator NarL; Provisional; Region: PRK10651 155864004973 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 155864004974 active site 155864004975 phosphorylation site [posttranslational modification] 155864004976 intermolecular recognition site; other site 155864004977 dimerization interface [polypeptide binding]; other site 155864004978 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 155864004979 DNA binding residues [nucleotide binding] 155864004980 dimerization interface [polypeptide binding]; other site 155864004981 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 155864004982 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 155864004983 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 155864004984 dimerization interface [polypeptide binding]; other site 155864004985 Histidine kinase; Region: HisKA_3; pfam07730 155864004986 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 155864004987 ATP binding site [chemical binding]; other site 155864004988 Mg2+ binding site [ion binding]; other site 155864004989 G-X-G motif; other site 155864004990 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 155864004991 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 155864004992 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 155864004993 [4Fe-4S] binding site [ion binding]; other site 155864004994 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 155864004995 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 155864004996 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 155864004997 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 155864004998 molybdopterin cofactor binding site; other site 155864004999 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 155864005000 4Fe-4S binding domain; Region: Fer4; cl02805 155864005001 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 155864005002 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 155864005003 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 155864005004 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 155864005005 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 155864005006 putative active site [active] 155864005007 putative substrate binding site [chemical binding]; other site 155864005008 putative cosubstrate binding site; other site 155864005009 catalytic site [active] 155864005010 SEC-C motif; Region: SEC-C; pfam02810 155864005011 hypothetical protein; Provisional; Region: PRK04233 155864005012 hypothetical protein; Provisional; Region: PRK10279 155864005013 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 155864005014 active site 155864005015 nucleophile elbow; other site 155864005016 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 155864005017 active site 155864005018 response regulator of RpoS; Provisional; Region: PRK10693 155864005019 phosphorylation site [posttranslational modification] 155864005020 intermolecular recognition site; other site 155864005021 dimerization interface [polypeptide binding]; other site 155864005022 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 155864005023 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 155864005024 active site 155864005025 tetramer interface; other site 155864005026 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 155864005027 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 155864005028 thymidine kinase; Provisional; Region: PRK04296 155864005029 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 155864005030 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 155864005031 putative catalytic cysteine [active] 155864005032 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 155864005033 putative active site [active] 155864005034 metal binding site [ion binding]; metal-binding site 155864005035 hypothetical protein; Provisional; Region: PRK11111 155864005036 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 155864005037 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 155864005038 peptide binding site [polypeptide binding]; other site 155864005039 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 155864005040 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 155864005041 dimer interface [polypeptide binding]; other site 155864005042 conserved gate region; other site 155864005043 putative PBP binding loops; other site 155864005044 ABC-ATPase subunit interface; other site 155864005045 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 155864005046 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 155864005047 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 155864005048 dimer interface [polypeptide binding]; other site 155864005049 conserved gate region; other site 155864005050 putative PBP binding loops; other site 155864005051 ABC-ATPase subunit interface; other site 155864005052 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 155864005053 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 155864005054 Walker A/P-loop; other site 155864005055 ATP binding site [chemical binding]; other site 155864005056 Q-loop/lid; other site 155864005057 ABC transporter signature motif; other site 155864005058 Walker B; other site 155864005059 D-loop; other site 155864005060 H-loop/switch region; other site 155864005061 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 155864005062 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 155864005063 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 155864005064 Walker A/P-loop; other site 155864005065 ATP binding site [chemical binding]; other site 155864005066 Q-loop/lid; other site 155864005067 ABC transporter signature motif; other site 155864005068 Walker B; other site 155864005069 D-loop; other site 155864005070 H-loop/switch region; other site 155864005071 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 155864005072 dsDNA-mimic protein; Reviewed; Region: PRK05094 155864005073 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 155864005074 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 155864005075 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 155864005076 putative active site [active] 155864005077 catalytic site [active] 155864005078 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 155864005079 putative active site [active] 155864005080 catalytic site [active] 155864005081 voltage-gated potassium channel; Provisional; Region: PRK10537 155864005082 Ion channel; Region: Ion_trans_2; pfam07885 155864005083 TrkA-N domain; Region: TrkA_N; pfam02254 155864005084 YciI-like protein; Reviewed; Region: PRK11370 155864005085 transport protein TonB; Provisional; Region: PRK10819 155864005086 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 155864005087 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 155864005088 intracellular septation protein A; Reviewed; Region: PRK00259 155864005089 hypothetical protein; Provisional; Region: PRK02868 155864005090 outer membrane protein W; Provisional; Region: PRK10959 155864005091 O-island #57; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864005092 Upstream copy of a 121 bp imperfect (95/121) inverted repeat flanking a large inversion relative to E. coli K-12 strain MG1655 155864005093 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 155864005094 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 155864005095 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 155864005096 dimer interface [polypeptide binding]; other site 155864005097 active site 155864005098 Int/Topo IB signature motif; other site 155864005099 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 155864005100 active site 155864005101 catalytic site [active] 155864005102 substrate binding site [chemical binding]; other site 155864005103 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 155864005104 DicB protein; Region: DicB; pfam05358 155864005105 transcriptional repressor DicA; Reviewed; Region: PRK09706 155864005106 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 155864005107 sequence-specific DNA binding site [nucleotide binding]; other site 155864005108 salt bridge; other site 155864005109 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 155864005110 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 155864005111 Pyocin large subunit [General function prediction only]; Region: COG5529 155864005112 Helix-turn-helix domain; Region: HTH_36; pfam13730 155864005113 primosomal protein DnaI; Provisional; Region: PRK02854 155864005114 O-island #57; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864005115 Protein of unknown function (DUF1627); Region: DUF1627; pfam07789 155864005116 Accessory colonization factor AcfC, contains ABC-type periplasmic domain [General function prediction only]; Region: AcfC; COG4588 155864005117 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 155864005118 Hok/gef family; Region: HOK_GEF; pfam01848 155864005119 Protein of unknown function (DUF968); Region: DUF968; pfam06147 155864005120 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 155864005121 Protein of unknown function (DUF1133); Region: DUF1133; pfam06576 155864005122 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 155864005123 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 155864005124 DNA methylase; Region: N6_N4_Mtase; pfam01555 155864005125 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 155864005126 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 155864005127 Domain of unknown function (DUF303); Region: DUF303; pfam03629 155864005128 O-island #57; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864005129 Lysis protein S; Region: Lysis_S; pfam04971 155864005130 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 155864005131 Phage-related lysozyme (muraminidase) [General function prediction only]; Region: COG3772 155864005132 catalytic residue [active] 155864005133 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 155864005134 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 155864005135 Integrase core domain; Region: rve; pfam00665 155864005136 Integrase core domain; Region: rve_3; pfam13683 155864005137 Transposase; Region: HTH_Tnp_1; cl17663 155864005138 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 155864005139 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 155864005140 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 155864005141 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 155864005142 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 155864005143 Protein of unknown function (DUF433); Region: DUF433; cl01030 155864005144 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 155864005145 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 155864005146 homodimer interface [polypeptide binding]; other site 155864005147 putative GKAP docking site [polypeptide binding]; other site 155864005148 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 155864005149 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 155864005150 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 155864005151 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 155864005152 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 155864005153 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 155864005154 MULE transposase domain; Region: MULE; pfam10551 155864005155 DinI-like family; Region: DinI; pfam06183 155864005156 O-island #57; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864005157 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 155864005158 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 155864005159 DNA binding site [nucleotide binding] 155864005160 active site 155864005161 Int/Topo IB signature motif; other site 155864005162 Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630 155864005163 DicB protein; Region: DicB; pfam05358 155864005164 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 155864005165 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 155864005166 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 155864005167 non-specific DNA binding site [nucleotide binding]; other site 155864005168 salt bridge; other site 155864005169 sequence-specific DNA binding site [nucleotide binding]; other site 155864005170 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 155864005171 Catalytic site [active] 155864005172 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 155864005173 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 155864005174 primosomal protein DnaI; Provisional; Region: PRK02854 155864005175 Protein of unknown function (DUF1627); Region: DUF1627; pfam07789 155864005176 Protein of unknown function (DUF551); Region: DUF551; pfam04448 155864005177 O-island #57; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864005178 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 155864005179 Protein of unknown function (DUF968); Region: DUF968; pfam06147 155864005180 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 155864005181 Protein of unknown function (DUF1133); Region: DUF1133; pfam06576 155864005182 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 155864005183 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 155864005184 Tellurite resistance protein [Inorganic ion transport and metabolism]; Region: TerB; COG3793 155864005185 tellurite resistance protein terB; Region: terB; cd07176 155864005186 putative metal binding site [ion binding]; other site 155864005187 Protein of unknown function (DUF3927); Region: DUF3927; pfam13064 155864005188 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 155864005189 Domain of unknown function (DUF303); Region: DUF303; pfam03629 155864005190 Transposase; Region: HTH_Tnp_1; cl17663 155864005191 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 155864005192 Integrase core domain; Region: rve; pfam00665 155864005193 Integrase core domain; Region: rve_3; pfam13683 155864005194 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 155864005195 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 155864005196 oligomer interface [polypeptide binding]; other site 155864005197 active site residues [active] 155864005198 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 155864005199 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 155864005200 O-island #57; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864005201 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 155864005202 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 155864005203 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 155864005204 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 155864005205 Protein of unknown function (DUF1441); Region: DUF1441; pfam07278 155864005206 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 155864005207 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 155864005208 catalytic residues [active] 155864005209 Lysis protein S; Region: Lysis_S; pfam04971 155864005210 Phage DNA packaging protein, Nu1 subunit of terminase [DNA replication, recombination, and repair]; Region: COG4220 155864005211 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 155864005212 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 155864005213 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 155864005214 homodimer interface [polypeptide binding]; other site 155864005215 putative GKAP docking site [polypeptide binding]; other site 155864005216 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 155864005217 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 155864005218 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 155864005219 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 155864005220 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 155864005221 O-island #57; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864005222 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 155864005223 gpW; Region: gpW; pfam02831 155864005224 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 155864005225 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 155864005226 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 155864005227 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 155864005228 tandem repeat interface [polypeptide binding]; other site 155864005229 oligomer interface [polypeptide binding]; other site 155864005230 active site residues [active] 155864005231 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 155864005232 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 155864005233 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 155864005234 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 155864005235 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894 155864005236 phage tail assembly protein T; Region: phage_lam_T; TIGR01715 155864005237 Phage-related minor tail protein [Function unknown]; Region: COG5281 155864005238 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 155864005239 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 155864005240 Phage-related protein [Function unknown]; Region: COG4718 155864005241 Phage-related protein [Function unknown]; Region: gp18; COG4672 155864005242 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 155864005243 MPN+ (JAMM) motif; other site 155864005244 Zinc-binding site [ion binding]; other site 155864005245 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 155864005246 NlpC/P60 family; Region: NLPC_P60; cl17555 155864005247 Phage-related protein, tail component [Function unknown]; Region: COG4723 155864005248 O-island #57; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864005249 Phage-related protein, tail component [Function unknown]; Region: COG4733 155864005250 Putative phage tail protein; Region: Phage-tail_3; pfam13550 155864005251 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 155864005252 Fibronectin type III protein; Region: DUF3672; pfam12421 155864005253 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 155864005254 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 155864005255 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 155864005256 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 155864005257 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 155864005258 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 155864005259 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 155864005260 DinI-like family; Region: DinI; pfam06183 155864005261 O-island #58; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864005262 metabolite-proton symporter; Region: 2A0106; TIGR00883 155864005263 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864005264 putative substrate translocation pore; other site 155864005265 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 155864005266 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 155864005267 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 155864005268 putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318 155864005269 Transcriptional regulators [Transcription]; Region: GntR; COG1802 155864005270 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 155864005271 DNA-binding site [nucleotide binding]; DNA binding site 155864005272 FCD domain; Region: FCD; pfam07729 155864005273 malonic semialdehyde reductase; Provisional; Region: PRK10538 155864005274 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 155864005275 putative NAD(P) binding site [chemical binding]; other site 155864005276 homodimer interface [polypeptide binding]; other site 155864005277 homotetramer interface [polypeptide binding]; other site 155864005278 active site 155864005279 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 155864005280 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 155864005281 active site 155864005282 Zn binding site [ion binding]; other site 155864005283 hypothetical protein; Validated; Region: PRK03657 155864005284 hypothetical protein; Provisional; Region: PRK10053 155864005285 diguanylate cyclase; Provisional; Region: PRK09894 155864005286 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 155864005287 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 155864005288 metal binding site [ion binding]; metal-binding site 155864005289 active site 155864005290 I-site; other site 155864005291 O-island #59; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864005292 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 155864005293 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 155864005294 conserved cys residue [active] 155864005295 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 155864005296 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 155864005297 active site residue [active] 155864005298 putative transporter; Provisional; Region: PRK10054 155864005299 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864005300 putative substrate translocation pore; other site 155864005301 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 155864005302 EamA-like transporter family; Region: EamA; pfam00892 155864005303 hypothetical protein; Provisional; Region: PRK10106 155864005304 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 155864005305 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 155864005306 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 155864005307 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 155864005308 inner membrane protein; Provisional; Region: PRK10995 155864005309 putative arabinose transporter; Provisional; Region: PRK03545 155864005310 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864005311 putative substrate translocation pore; other site 155864005312 Transcriptional regulator [Transcription]; Region: LysR; COG0583 155864005313 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 155864005314 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 155864005315 putative dimerization interface [polypeptide binding]; other site 155864005316 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 155864005317 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 155864005318 NAD(P) binding site [chemical binding]; other site 155864005319 catalytic residues [active] 155864005320 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 155864005321 glutaminase; Provisional; Region: PRK00971 155864005322 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 155864005323 O-island #60; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864005324 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 155864005325 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 155864005326 metal binding site [ion binding]; metal-binding site 155864005327 active site 155864005328 I-site; other site 155864005329 altronate oxidoreductase; Provisional; Region: PRK03643 155864005330 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 155864005331 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 155864005332 Predicted membrane protein [Function unknown]; Region: COG3781 155864005333 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 155864005334 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 155864005335 S-adenosylmethionine binding site [chemical binding]; other site 155864005336 autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486 155864005337 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 155864005338 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 155864005339 putative active site; other site 155864005340 catalytic residue [active] 155864005341 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 155864005342 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 155864005343 ligand binding site [chemical binding]; other site 155864005344 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 155864005345 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 155864005346 TM-ABC transporter signature motif; other site 155864005347 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 155864005348 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 155864005349 TM-ABC transporter signature motif; other site 155864005350 autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439 155864005351 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 155864005352 Walker A/P-loop; other site 155864005353 ATP binding site [chemical binding]; other site 155864005354 Q-loop/lid; other site 155864005355 ABC transporter signature motif; other site 155864005356 Walker B; other site 155864005357 D-loop; other site 155864005358 H-loop/switch region; other site 155864005359 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 155864005360 transcriptional regulator LsrR; Provisional; Region: PRK15418 155864005361 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 155864005362 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 155864005363 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 155864005364 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 155864005365 putative N- and C-terminal domain interface [polypeptide binding]; other site 155864005366 putative active site [active] 155864005367 putative MgATP binding site [chemical binding]; other site 155864005368 catalytic site [active] 155864005369 metal binding site [ion binding]; metal-binding site 155864005370 putative carbohydrate binding site [chemical binding]; other site 155864005371 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 155864005372 putative lipoprotein; Provisional; Region: PRK09707 155864005373 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 155864005374 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 155864005375 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 155864005376 Autotransporter beta-domain; Region: Autotransporter; pfam03797 155864005377 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 155864005378 HipA-like N-terminal domain; Region: HipA_N; pfam07805 155864005379 HipA-like C-terminal domain; Region: HipA_C; pfam07804 155864005380 Dif; recA-independent recombination site in terminus 155864005381 Helix-turn-helix domain; Region: HTH_18; pfam12833 155864005382 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 155864005383 O-island #61; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864005384 Fimbrial protein; Region: Fimbrial; cl01416 155864005385 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 155864005386 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 155864005387 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 155864005388 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 155864005389 PapC N-terminal domain; Region: PapC_N; pfam13954 155864005390 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 155864005391 PapC C-terminal domain; Region: PapC_C; pfam13953 155864005392 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 155864005393 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 155864005394 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 155864005395 mannosyl binding site [chemical binding]; other site 155864005396 Fimbrial protein; Region: Fimbrial; pfam00419 155864005397 putative oxidoreductase; Provisional; Region: PRK09939 155864005398 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 155864005399 putative molybdopterin cofactor binding site [chemical binding]; other site 155864005400 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 155864005401 putative molybdopterin cofactor binding site; other site 155864005402 transcriptional regulator YdeO; Provisional; Region: PRK09940 155864005403 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 155864005404 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 155864005405 Sulfatase; Region: Sulfatase; pfam00884 155864005406 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 155864005407 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 155864005408 FeS/SAM binding site; other site 155864005409 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 155864005410 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 155864005411 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 155864005412 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 155864005413 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 155864005414 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 155864005415 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 155864005416 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 155864005417 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 155864005418 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 155864005419 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 155864005420 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 155864005421 pyridoxal 5'-phosphate binding site [chemical binding]; other site 155864005422 catalytic residue [active] 155864005423 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 155864005424 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 155864005425 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 155864005426 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 155864005427 heme-binding site [chemical binding]; other site 155864005428 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 155864005429 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 155864005430 metal binding site [ion binding]; metal-binding site 155864005431 active site 155864005432 I-site; other site 155864005433 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 155864005434 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 155864005435 putative active site [active] 155864005436 heme pocket [chemical binding]; other site 155864005437 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 155864005438 putative active site [active] 155864005439 heme pocket [chemical binding]; other site 155864005440 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 155864005441 metal binding site [ion binding]; metal-binding site 155864005442 active site 155864005443 I-site; other site 155864005444 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 155864005445 D-alanyl-D-alanine dipeptidase; Provisional; Region: PRK10178 155864005446 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 155864005447 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 155864005448 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 155864005449 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 155864005450 dimer interface [polypeptide binding]; other site 155864005451 conserved gate region; other site 155864005452 putative PBP binding loops; other site 155864005453 ABC-ATPase subunit interface; other site 155864005454 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 155864005455 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 155864005456 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 155864005457 dimer interface [polypeptide binding]; other site 155864005458 conserved gate region; other site 155864005459 putative PBP binding loops; other site 155864005460 ABC-ATPase subunit interface; other site 155864005461 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 155864005462 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 155864005463 Walker A/P-loop; other site 155864005464 ATP binding site [chemical binding]; other site 155864005465 Q-loop/lid; other site 155864005466 ABC transporter signature motif; other site 155864005467 Walker B; other site 155864005468 D-loop; other site 155864005469 H-loop/switch region; other site 155864005470 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 155864005471 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 155864005472 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 155864005473 Walker A/P-loop; other site 155864005474 ATP binding site [chemical binding]; other site 155864005475 Q-loop/lid; other site 155864005476 ABC transporter signature motif; other site 155864005477 Walker B; other site 155864005478 D-loop; other site 155864005479 H-loop/switch region; other site 155864005480 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 155864005481 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 155864005482 Putative biofilm-dependent modulation protein; Region: BDM; cl11581 155864005483 30S ribosomal subunit S22; Reviewed; Region: rpsV; PRK10057 155864005484 malate dehydrogenase; Provisional; Region: PRK13529 155864005485 Malic enzyme, N-terminal domain; Region: malic; pfam00390 155864005486 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 155864005487 NAD(P) binding site [chemical binding]; other site 155864005488 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 155864005489 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 155864005490 NAD binding site [chemical binding]; other site 155864005491 substrate binding site [chemical binding]; other site 155864005492 catalytic Zn binding site [ion binding]; other site 155864005493 tetramer interface [polypeptide binding]; other site 155864005494 structural Zn binding site [ion binding]; other site 155864005495 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 155864005496 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 155864005497 non-specific DNA binding site [nucleotide binding]; other site 155864005498 salt bridge; other site 155864005499 sequence-specific DNA binding site [nucleotide binding]; other site 155864005500 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 155864005501 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 155864005502 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 155864005503 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 155864005504 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 155864005505 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 155864005506 [4Fe-4S] binding site [ion binding]; other site 155864005507 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 155864005508 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 155864005509 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 155864005510 molybdopterin cofactor binding site; other site 155864005511 aromatic amino acid exporter; Provisional; Region: PRK11689 155864005512 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 155864005513 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 155864005514 trimer interface [polypeptide binding]; other site 155864005515 eyelet of channel; other site 155864005516 O-island #62; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864005517 O-island #63; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864005518 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 155864005519 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 155864005520 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 155864005521 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 155864005522 [4Fe-4S] binding site [ion binding]; other site 155864005523 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 155864005524 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 155864005525 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 155864005526 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 155864005527 molybdopterin cofactor binding site; other site 155864005528 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 155864005529 nitrate reductase 2 subunit delta; Provisional; Region: PRK15054 155864005530 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 155864005531 hypothetical protein; Provisional; Region: PRK10281 155864005532 N-acetyltransferase; Region: Acetyltransf_2; cl00949 155864005533 N-acetyltransferase; Region: Acetyltransf_2; cl00949 155864005534 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 155864005535 4-oxalocrotonate tautomerase; Provisional; Region: PRK01271 155864005536 active site 1 [active] 155864005537 dimer interface [polypeptide binding]; other site 155864005538 hexamer interface [polypeptide binding]; other site 155864005539 active site 2 [active] 155864005540 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 155864005541 Transposase [DNA replication, recombination, and repair]; Region: COG5433 155864005542 O-island #64; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864005543 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 155864005544 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 155864005545 RHS protein; Region: RHS; pfam03527 155864005546 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 155864005547 O-island #65; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864005548 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 155864005549 RHS Repeat; Region: RHS_repeat; cl11982 155864005550 RHS Repeat; Region: RHS_repeat; cl11982 155864005551 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 155864005552 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 155864005553 RHS Repeat; Region: RHS_repeat; cl11982 155864005554 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 155864005555 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 155864005556 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 155864005557 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 155864005558 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 155864005559 C-terminal domain interface [polypeptide binding]; other site 155864005560 GSH binding site (G-site) [chemical binding]; other site 155864005561 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 155864005562 dimer interface [polypeptide binding]; other site 155864005563 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 155864005564 dimer interface [polypeptide binding]; other site 155864005565 N-terminal domain interface [polypeptide binding]; other site 155864005566 substrate binding pocket (H-site) [chemical binding]; other site 155864005567 L-asparagine permease; Provisional; Region: PRK15049 155864005568 PQQ-like domain; Region: PQQ_2; pfam13360 155864005569 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 155864005570 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 155864005571 N-terminal plug; other site 155864005572 ligand-binding site [chemical binding]; other site 155864005573 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 155864005574 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 155864005575 DNA-binding site [nucleotide binding]; DNA binding site 155864005576 FCD domain; Region: FCD; pfam07729 155864005577 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 155864005578 Prostaglandin dehydrogenases; Region: PGDH; cd05288 155864005579 NAD(P) binding site [chemical binding]; other site 155864005580 substrate binding site [chemical binding]; other site 155864005581 dimer interface [polypeptide binding]; other site 155864005582 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 155864005583 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 155864005584 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 155864005585 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 155864005586 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 155864005587 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 155864005588 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 155864005589 tetrameric interface [polypeptide binding]; other site 155864005590 NAD binding site [chemical binding]; other site 155864005591 catalytic residues [active] 155864005592 substrate binding site [chemical binding]; other site 155864005593 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 155864005594 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 155864005595 ABC-ATPase subunit interface; other site 155864005596 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 155864005597 dimer interface [polypeptide binding]; other site 155864005598 conserved gate region; other site 155864005599 putative PBP binding loops; other site 155864005600 ABC-ATPase subunit interface; other site 155864005601 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 155864005602 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 155864005603 Walker A/P-loop; other site 155864005604 ATP binding site [chemical binding]; other site 155864005605 Q-loop/lid; other site 155864005606 ABC transporter signature motif; other site 155864005607 Walker B; other site 155864005608 D-loop; other site 155864005609 H-loop/switch region; other site 155864005610 TOBE domain; Region: TOBE_2; pfam08402 155864005611 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 155864005612 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 155864005613 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 155864005614 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 155864005615 DNA-binding site [nucleotide binding]; DNA binding site 155864005616 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 155864005617 pyridoxal 5'-phosphate binding site [chemical binding]; other site 155864005618 homodimer interface [polypeptide binding]; other site 155864005619 catalytic residue [active] 155864005620 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 155864005621 Helix-turn-helix; Region: HTH_3; pfam01381 155864005622 sequence-specific DNA binding site [nucleotide binding]; other site 155864005623 salt bridge; other site 155864005624 Protein of unknown function (DUF2554); Region: DUF2554; pfam10829 155864005625 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 155864005626 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 155864005627 Peptidase family U32; Region: Peptidase_U32; pfam01136 155864005628 Collagenase; Region: DUF3656; pfam12392 155864005629 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 155864005630 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 155864005631 non-specific DNA binding site [nucleotide binding]; other site 155864005632 salt bridge; other site 155864005633 sequence-specific DNA binding site [nucleotide binding]; other site 155864005634 Cupin domain; Region: Cupin_2; pfam07883 155864005635 benzoate transporter; Region: benE; TIGR00843 155864005636 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 155864005637 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 155864005638 tellurite resistance protein TehB; Provisional; Region: PRK11207 155864005639 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 155864005640 S-adenosylmethionine binding site [chemical binding]; other site 155864005641 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 155864005642 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 155864005643 gating phenylalanine in ion channel; other site 155864005644 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 155864005645 putative trimer interface [polypeptide binding]; other site 155864005646 putative CoA binding site [chemical binding]; other site 155864005647 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 155864005648 putative trimer interface [polypeptide binding]; other site 155864005649 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 155864005650 putative CoA binding site [chemical binding]; other site 155864005651 putative trimer interface [polypeptide binding]; other site 155864005652 putative CoA binding site [chemical binding]; other site 155864005653 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 155864005654 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 155864005655 hypothetical protein; Provisional; Region: PRK11415 155864005656 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 155864005657 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 155864005658 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 155864005659 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 155864005660 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 155864005661 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 155864005662 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 155864005663 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 155864005664 dimerization interface [polypeptide binding]; other site 155864005665 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 155864005666 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 155864005667 dimer interface [polypeptide binding]; other site 155864005668 ligand binding site [chemical binding]; other site 155864005669 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 155864005670 dimerization interface [polypeptide binding]; other site 155864005671 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 155864005672 dimer interface [polypeptide binding]; other site 155864005673 putative CheW interface [polypeptide binding]; other site 155864005674 hypothetical protein; Provisional; Region: PRK10040 155864005675 cytochrome b561; Provisional; Region: PRK11513 155864005676 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 155864005677 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 155864005678 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 155864005679 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 155864005680 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 155864005681 NAD binding site [chemical binding]; other site 155864005682 catalytic residues [active] 155864005683 substrate binding site [chemical binding]; other site 155864005684 Uncharacterized conserved protein [Function unknown]; Region: COG1434 155864005685 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 155864005686 putative active site [active] 155864005687 O-island #66; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864005688 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 155864005689 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 155864005690 ATP binding site [chemical binding]; other site 155864005691 putative Mg++ binding site [ion binding]; other site 155864005692 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 155864005693 nucleotide binding region [chemical binding]; other site 155864005694 ATP-binding site [chemical binding]; other site 155864005695 Helicase associated domain (HA2); Region: HA2; pfam04408 155864005696 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 155864005697 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 155864005698 azoreductase; Reviewed; Region: PRK00170 155864005699 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 155864005700 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 155864005701 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 155864005702 active site 155864005703 Dual specificity phosphatase, catalytic domain; Region: DSPc; smart00195 155864005704 active site 155864005705 catalytic residues [active] 155864005706 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 155864005707 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 155864005708 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 155864005709 S-adenosylmethionine binding site [chemical binding]; other site 155864005710 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 155864005711 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 155864005712 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 155864005713 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 155864005714 Protein of unknown function (DUF2773); Region: DUF2773; pfam10971 155864005715 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 155864005716 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 155864005717 active site 155864005718 catalytic tetrad [active] 155864005719 Autotransporter beta-domain; Region: Autotransporter; pfam03797 155864005720 O-island #67; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864005721 O-island #67; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864005722 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 155864005723 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 155864005724 hypothetical protein; Provisional; Region: PRK10695 155864005725 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 155864005726 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 155864005727 putative ligand binding site [chemical binding]; other site 155864005728 putative NAD binding site [chemical binding]; other site 155864005729 catalytic site [active] 155864005730 heat-inducible protein; Provisional; Region: PRK10449 155864005731 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 155864005732 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 155864005733 dimer interface [polypeptide binding]; other site 155864005734 PYR/PP interface [polypeptide binding]; other site 155864005735 TPP binding site [chemical binding]; other site 155864005736 substrate binding site [chemical binding]; other site 155864005737 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 155864005738 Domain of unknown function; Region: EKR; smart00890 155864005739 4Fe-4S binding domain; Region: Fer4_6; pfam12837 155864005740 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 155864005741 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 155864005742 TPP-binding site [chemical binding]; other site 155864005743 dimer interface [polypeptide binding]; other site 155864005744 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 155864005745 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 155864005746 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 155864005747 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 155864005748 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 155864005749 Ligand Binding Site [chemical binding]; other site 155864005750 Cryptic prophage CP-933R; includes one copy of the 26 bp direct repeat that flanks the prophage; related to K-12 MG1655 prophage Rac 155864005751 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 155864005752 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 155864005753 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 155864005754 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 155864005755 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 155864005756 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 155864005757 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 155864005758 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 155864005759 Phage-related protein, tail component [Function unknown]; Region: COG4733 155864005760 Putative phage tail protein; Region: Phage-tail_3; pfam13550 155864005761 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 155864005762 Interdomain contacts; other site 155864005763 Cytokine receptor motif; other site 155864005764 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 155864005765 Fibronectin type III protein; Region: DUF3672; pfam12421 155864005766 Phage-related protein, tail component [Function unknown]; Region: COG4733 155864005767 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 155864005768 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 155864005769 E-class dimer interface [polypeptide binding]; other site 155864005770 P-class dimer interface [polypeptide binding]; other site 155864005771 active site 155864005772 Cu2+ binding site [ion binding]; other site 155864005773 Zn2+ binding site [ion binding]; other site 155864005774 Cryptic prophage CP-933R; includes one copy of the 26 bp direct repeat that flanks the prophage; related to K-12 MG1655 prophage Rac 155864005775 Phage-related protein, tail component [Function unknown]; Region: COG4723 155864005776 Phage-related protein, tail component [Function unknown]; Region: COG4723 155864005777 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 155864005778 MPN+ (JAMM) motif; other site 155864005779 Zinc-binding site [ion binding]; other site 155864005780 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 155864005781 NlpC/P60 family; Region: NLPC_P60; cl17555 155864005782 Phage-related protein [Function unknown]; Region: gp18; COG4672 155864005783 Phage-related protein [Function unknown]; Region: COG4718 155864005784 Phage-related minor tail protein [Function unknown]; Region: COG5281 155864005785 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 155864005786 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 155864005787 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 155864005788 phage tail assembly protein T; Region: phage_lam_T; TIGR01715 155864005789 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894 155864005790 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 155864005791 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 155864005792 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 155864005793 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 155864005794 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 155864005795 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 155864005796 tandem repeat interface [polypeptide binding]; other site 155864005797 oligomer interface [polypeptide binding]; other site 155864005798 active site residues [active] 155864005799 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 155864005800 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 155864005801 gpW; Region: gpW; pfam02831 155864005802 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 155864005803 Phage DNA packaging protein, Nu1 subunit of terminase [DNA replication, recombination, and repair]; Region: COG4220 155864005804 Cryptic prophage CP-933R; includes one copy of the 26 bp direct repeat that flanks the prophage; related to K-12 MG1655 prophage Rac 155864005805 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 155864005806 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 155864005807 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 155864005808 catalytic residues [active] 155864005809 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 155864005810 Lysis protein S; Region: Lysis_S; pfam04971 155864005811 Transposase; Region: HTH_Tnp_1; cl17663 155864005812 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 155864005813 Integrase core domain; Region: rve; pfam00665 155864005814 Integrase core domain; Region: rve_3; pfam13683 155864005815 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 155864005816 Domain of unknown function (DUF303); Region: DUF303; pfam03629 155864005817 Protein of unknown function (DUF3927); Region: DUF3927; pfam13064 155864005818 tellurium resistance terB-like protein; Region: terB_like; cl11965 155864005819 tellurite resistance protein terB; Region: terB; cd07176 155864005820 putative metal binding site [ion binding]; other site 155864005821 Protein of unknown function (DUF1133); Region: DUF1133; pfam06576 155864005822 Protein of unknown function (DUF1133); Region: DUF1133; pfam06576 155864005823 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 155864005824 Cryptic prophage CP-933R; includes one copy of the 26 bp direct repeat that flanks the prophage; related to K-12 MG1655 prophage Rac 155864005825 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 155864005826 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 155864005827 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 155864005828 cofactor binding site; other site 155864005829 DNA binding site [nucleotide binding] 155864005830 substrate interaction site [chemical binding]; other site 155864005831 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 155864005832 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 155864005833 Protein of unknown function (DUF1627); Region: DUF1627; pfam07789 155864005834 putative replication protein; Provisional; Region: PRK12377 155864005835 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 155864005836 Walker A motif; other site 155864005837 ATP binding site [chemical binding]; other site 155864005838 primosomal protein DnaI; Provisional; Region: PRK02854 155864005839 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 155864005840 Helix-turn-helix domain; Region: HTH_17; cl17695 155864005841 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 155864005842 non-specific DNA binding site [nucleotide binding]; other site 155864005843 salt bridge; other site 155864005844 sequence-specific DNA binding site [nucleotide binding]; other site 155864005845 Superinfection exclusion protein B; Region: SieB; pfam14163 155864005846 Cryptic prophage CP-933R; includes one copy of the 26 bp direct repeat that flanks the prophage; related to K-12 MG1655 prophage Rac 155864005847 FtsZ inhibitor protein; Reviewed; Region: kil; PRK11354 155864005848 hypothetical protein; Reviewed; Region: PRK09790 155864005849 exonuclease VIII; Reviewed; Region: PRK09709 155864005850 Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630 155864005851 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 155864005852 recombination and repair protein RecT; Reviewed; Region: recT; PRK09846 155864005853 restriction alleviation and modification protein; Reviewed; Region: lar; PRK09710 155864005854 hypothetical protein; Provisional; Region: PRK09750 155864005855 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 155864005856 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 155864005857 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 155864005858 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 155864005859 Int/Topo IB signature motif; other site 155864005860 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 155864005861 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 155864005862 Ligand Binding Site [chemical binding]; other site 155864005863 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 155864005864 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 155864005865 ATP binding site [chemical binding]; other site 155864005866 Mg++ binding site [ion binding]; other site 155864005867 motif III; other site 155864005868 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 155864005869 nucleotide binding region [chemical binding]; other site 155864005870 ATP-binding site [chemical binding]; other site 155864005871 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 155864005872 putative RNA binding site [nucleotide binding]; other site 155864005873 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 155864005874 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 155864005875 Cl binding site [ion binding]; other site 155864005876 oligomer interface [polypeptide binding]; other site 155864005877 PAS domain S-box; Region: sensory_box; TIGR00229 155864005878 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 155864005879 putative active site [active] 155864005880 heme pocket [chemical binding]; other site 155864005881 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 155864005882 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 155864005883 metal binding site [ion binding]; metal-binding site 155864005884 active site 155864005885 I-site; other site 155864005886 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 155864005887 Smr domain; Region: Smr; pfam01713 155864005888 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 155864005889 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 155864005890 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 155864005891 putative substrate binding pocket [chemical binding]; other site 155864005892 putative dimerization interface [polypeptide binding]; other site 155864005893 M20 Peptidases Aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase from bacteria and archaea; Region: M20_Acy1_IAAspH_bact; cd05665 155864005894 amidohydrolase; Region: amidohydrolases; TIGR01891 155864005895 putative metal binding site [ion binding]; other site 155864005896 dimer interface [polypeptide binding]; other site 155864005897 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 155864005898 amidohydrolase; Region: amidohydrolases; TIGR01891 155864005899 putative metal binding site [ion binding]; other site 155864005900 AbgT putative transporter family; Region: ABG_transport; cl17431 155864005901 O-island #68; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864005902 Transposase; Region: HTH_Tnp_1; cl17663 155864005903 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 155864005904 Integrase core domain; Region: rve; pfam00665 155864005905 Integrase core domain; Region: rve_3; pfam13683 155864005906 AbgT putative transporter family; Region: ABG_transport; cl17431 155864005907 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 155864005908 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 155864005909 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 155864005910 DNA binding site [nucleotide binding] 155864005911 active site 155864005912 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 155864005913 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 155864005914 ligand binding site [chemical binding]; other site 155864005915 flexible hinge region; other site 155864005916 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 155864005917 putative switch regulator; other site 155864005918 non-specific DNA interactions [nucleotide binding]; other site 155864005919 DNA binding site [nucleotide binding] 155864005920 sequence specific DNA binding site [nucleotide binding]; other site 155864005921 putative cAMP binding site [chemical binding]; other site 155864005922 universal stress protein UspE; Provisional; Region: PRK11175 155864005923 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 155864005924 Ligand Binding Site [chemical binding]; other site 155864005925 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 155864005926 Ligand Binding Site [chemical binding]; other site 155864005927 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 155864005928 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 155864005929 Mechanosensitive ion channel; Region: MS_channel; pfam00924 155864005930 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 155864005931 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 155864005932 peptide binding site [polypeptide binding]; other site 155864005933 Transcriptional regulator [Transcription]; Region: LysR; COG0583 155864005934 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 155864005935 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 155864005936 putative effector binding pocket; other site 155864005937 putative dimerization interface [polypeptide binding]; other site 155864005938 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 155864005939 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 155864005940 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 155864005941 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 155864005942 O-island #69; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864005943 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 155864005944 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 155864005945 NADH(P)-binding; Region: NAD_binding_10; pfam13460 155864005946 putative NAD(P) binding site [chemical binding]; other site 155864005947 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 155864005948 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 155864005949 putative active site [active] 155864005950 Zn binding site [ion binding]; other site 155864005951 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 155864005952 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 155864005953 active site 155864005954 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 155864005955 dimer interface [polypeptide binding]; other site 155864005956 catalytic triad [active] 155864005957 peroxidatic and resolving cysteines [active] 155864005958 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 155864005959 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 155864005960 putative aromatic amino acid binding site; other site 155864005961 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 155864005962 Walker A motif; other site 155864005963 ATP binding site [chemical binding]; other site 155864005964 Walker B motif; other site 155864005965 arginine finger; other site 155864005966 hypothetical protein; Provisional; Region: PRK05415 155864005967 TIGR01620 family protein; Region: hyp_HI0043 155864005968 Predicted ATPase [General function prediction only]; Region: COG3106 155864005969 Transcriptional regulators [Transcription]; Region: PurR; COG1609 155864005970 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 155864005971 DNA binding site [nucleotide binding] 155864005972 domain linker motif; other site 155864005973 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 155864005974 putative dimerization interface [polypeptide binding]; other site 155864005975 putative ligand binding site [chemical binding]; other site 155864005976 Outer membrane protein G (OmpG); Region: Porin_OmpG; pfam09381 155864005977 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 155864005978 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 155864005979 Walker A/P-loop; other site 155864005980 ATP binding site [chemical binding]; other site 155864005981 Q-loop/lid; other site 155864005982 ABC transporter signature motif; other site 155864005983 Walker B; other site 155864005984 D-loop; other site 155864005985 H-loop/switch region; other site 155864005986 TOBE domain; Region: TOBE_2; pfam08402 155864005987 beta-phosphoglucomutase; Region: bPGM; TIGR01990 155864005988 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 155864005989 motif II; other site 155864005990 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 155864005991 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 155864005992 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 155864005993 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 155864005994 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 155864005995 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 155864005996 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 155864005997 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 155864005998 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 155864005999 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 155864006000 putative NAD(P) binding site [chemical binding]; other site 155864006001 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 155864006002 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 155864006003 dimer interface [polypeptide binding]; other site 155864006004 conserved gate region; other site 155864006005 putative PBP binding loops; other site 155864006006 ABC-ATPase subunit interface; other site 155864006007 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 155864006008 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 155864006009 dimer interface [polypeptide binding]; other site 155864006010 conserved gate region; other site 155864006011 putative PBP binding loops; other site 155864006012 ABC-ATPase subunit interface; other site 155864006013 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 155864006014 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 155864006015 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 155864006016 sucrose phosphorylase; Provisional; Region: PRK13840 155864006017 active site 155864006018 homodimer interface [polypeptide binding]; other site 155864006019 catalytic site [active] 155864006020 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 155864006021 active site residue [active] 155864006022 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 155864006023 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 155864006024 phage shock protein C; Region: phageshock_pspC; TIGR02978 155864006025 phage shock protein B; Provisional; Region: pspB; PRK09458 155864006026 phage shock protein PspA; Provisional; Region: PRK10698 155864006027 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 155864006028 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 155864006029 Walker A motif; other site 155864006030 ATP binding site [chemical binding]; other site 155864006031 Walker B motif; other site 155864006032 arginine finger; other site 155864006033 4-aminobutyrate transaminase; Provisional; Region: PRK09792 155864006034 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 155864006035 inhibitor-cofactor binding pocket; inhibition site 155864006036 pyridoxal 5'-phosphate binding site [chemical binding]; other site 155864006037 catalytic residue [active] 155864006038 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 155864006039 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 155864006040 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 155864006041 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 155864006042 NAD(P) binding site [chemical binding]; other site 155864006043 catalytic residues [active] 155864006044 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 155864006045 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 155864006046 non-specific DNA binding site [nucleotide binding]; other site 155864006047 salt bridge; other site 155864006048 sequence-specific DNA binding site [nucleotide binding]; other site 155864006049 Cupin domain; Region: Cupin_2; pfam07883 155864006050 gamma-glutamyl-gamma-aminobutyrate hydrolase; Provisional; Region: puuD; PRK11366 155864006051 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 155864006052 catalytic triad [active] 155864006053 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 155864006054 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 155864006055 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 155864006056 Protein of unknown function (DUF2543); Region: DUF2543; pfam10820 155864006057 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 155864006058 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 155864006059 peptide binding site [polypeptide binding]; other site 155864006060 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 155864006061 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 155864006062 dimer interface [polypeptide binding]; other site 155864006063 conserved gate region; other site 155864006064 putative PBP binding loops; other site 155864006065 ABC-ATPase subunit interface; other site 155864006066 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 155864006067 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 155864006068 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 155864006069 dimer interface [polypeptide binding]; other site 155864006070 conserved gate region; other site 155864006071 putative PBP binding loops; other site 155864006072 ABC-ATPase subunit interface; other site 155864006073 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 155864006074 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 155864006075 Walker A/P-loop; other site 155864006076 ATP binding site [chemical binding]; other site 155864006077 Q-loop/lid; other site 155864006078 ABC transporter signature motif; other site 155864006079 Walker B; other site 155864006080 D-loop; other site 155864006081 H-loop/switch region; other site 155864006082 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 155864006083 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 155864006084 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 155864006085 Walker A/P-loop; other site 155864006086 ATP binding site [chemical binding]; other site 155864006087 Q-loop/lid; other site 155864006088 ABC transporter signature motif; other site 155864006089 Walker B; other site 155864006090 D-loop; other site 155864006091 H-loop/switch region; other site 155864006092 O-island #70; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864006093 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864006094 putative substrate translocation pore; other site 155864006095 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 155864006096 Outer membrane efflux protein; Region: OEP; pfam02321 155864006097 Outer membrane efflux protein; Region: OEP; pfam02321 155864006098 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 155864006099 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 155864006100 Protein export membrane protein; Region: SecD_SecF; cl14618 155864006101 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 155864006102 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 155864006103 HlyD family secretion protein; Region: HlyD_3; pfam13437 155864006104 O-island #70; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864006105 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 155864006106 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 155864006107 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 155864006108 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 155864006109 NAD binding site [chemical binding]; other site 155864006110 homotetramer interface [polypeptide binding]; other site 155864006111 homodimer interface [polypeptide binding]; other site 155864006112 substrate binding site [chemical binding]; other site 155864006113 active site 155864006114 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 155864006115 Uncharacterized conserved protein [Function unknown]; Region: COG2128 155864006116 exoribonuclease II; Provisional; Region: PRK05054 155864006117 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 155864006118 RNB domain; Region: RNB; pfam00773 155864006119 S1 RNA binding domain; Region: S1; pfam00575 155864006120 RNase II stability modulator; Provisional; Region: PRK10060 155864006121 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 155864006122 putative active site [active] 155864006123 heme pocket [chemical binding]; other site 155864006124 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 155864006125 metal binding site [ion binding]; metal-binding site 155864006126 active site 155864006127 I-site; other site 155864006128 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 155864006129 hypothetical protein; Provisional; Region: PRK13658 155864006130 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 155864006131 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 155864006132 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 155864006133 lipoprotein; Provisional; Region: PRK10540 155864006134 translation initiation factor Sui1; Validated; Region: PRK06824 155864006135 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 155864006136 putative rRNA binding site [nucleotide binding]; other site 155864006137 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 155864006138 active site 155864006139 dimer interface [polypeptide binding]; other site 155864006140 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 155864006141 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 155864006142 TPR motif; other site 155864006143 binding surface 155864006144 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 155864006145 binding surface 155864006146 TPR motif; other site 155864006147 Predicted membrane protein [Function unknown]; Region: COG3771 155864006148 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 155864006149 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 155864006150 active site 155864006151 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 155864006152 dimerization interface [polypeptide binding]; other site 155864006153 active site 155864006154 aconitate hydratase; Validated; Region: PRK09277 155864006155 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 155864006156 substrate binding site [chemical binding]; other site 155864006157 ligand binding site [chemical binding]; other site 155864006158 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 155864006159 substrate binding site [chemical binding]; other site 155864006160 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 155864006161 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 155864006162 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 155864006163 substrate binding site [chemical binding]; other site 155864006164 putative dimerization interface [polypeptide binding]; other site 155864006165 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 155864006166 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 155864006167 active site 155864006168 interdomain interaction site; other site 155864006169 putative metal-binding site [ion binding]; other site 155864006170 nucleotide binding site [chemical binding]; other site 155864006171 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 155864006172 domain I; other site 155864006173 DNA binding groove [nucleotide binding] 155864006174 phosphate binding site [ion binding]; other site 155864006175 domain II; other site 155864006176 domain III; other site 155864006177 nucleotide binding site [chemical binding]; other site 155864006178 catalytic site [active] 155864006179 domain IV; other site 155864006180 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 155864006181 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 155864006182 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 155864006183 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 155864006184 hypothetical protein; Provisional; Region: PRK11037 155864006185 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 155864006186 putative inner membrane peptidase; Provisional; Region: PRK11778 155864006187 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 155864006188 tandem repeat interface [polypeptide binding]; other site 155864006189 oligomer interface [polypeptide binding]; other site 155864006190 active site residues [active] 155864006191 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 155864006192 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 155864006193 NADP binding site [chemical binding]; other site 155864006194 homodimer interface [polypeptide binding]; other site 155864006195 active site 155864006196 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 155864006197 cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase; Validated; Region: PRK05986 155864006198 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 155864006199 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 155864006200 RNA binding surface [nucleotide binding]; other site 155864006201 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 155864006202 probable active site [active] 155864006203 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 155864006204 hypothetical protein; Provisional; Region: PRK11630 155864006205 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 155864006206 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 155864006207 active site 155864006208 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 155864006209 anthranilate synthase component I; Provisional; Region: PRK13564 155864006210 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 155864006211 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 155864006212 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 155864006213 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 155864006214 glutamine binding [chemical binding]; other site 155864006215 catalytic triad [active] 155864006216 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 155864006217 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 155864006218 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 155864006219 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 155864006220 active site 155864006221 ribulose/triose binding site [chemical binding]; other site 155864006222 phosphate binding site [ion binding]; other site 155864006223 substrate (anthranilate) binding pocket [chemical binding]; other site 155864006224 product (indole) binding pocket [chemical binding]; other site 155864006225 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 155864006226 active site 155864006227 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 155864006228 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 155864006229 pyridoxal 5'-phosphate binding site [chemical binding]; other site 155864006230 catalytic residue [active] 155864006231 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 155864006232 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 155864006233 substrate binding site [chemical binding]; other site 155864006234 active site 155864006235 catalytic residues [active] 155864006236 heterodimer interface [polypeptide binding]; other site 155864006237 General stress protein [General function prediction only]; Region: GsiB; COG3729 155864006238 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 155864006239 dimerization interface [polypeptide binding]; other site 155864006240 metal binding site [ion binding]; metal-binding site 155864006241 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 155864006242 Downstream copy of a 121 bp imperfect (95/121) inverted repeat flanking a large inversion relative to E. coli K-12 strain MG1655 155864006243 OmpW family; Region: OmpW; cl17427 155864006244 O-island #71; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655; includes cryptic prophage CP-933P 155864006245 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 155864006246 Homeodomain-like domain; Region: HTH_23; cl17451 155864006247 DDE superfamily endonuclease; Region: DDE_3; pfam13358 155864006248 IpaB/EvcA family; Region: IpaB_EvcA; pfam03278 155864006249 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 155864006250 Transposase; Region: HTH_Tnp_1; pfam01527 155864006251 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 155864006252 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 155864006253 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 155864006254 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 155864006255 homodimer interface [polypeptide binding]; other site 155864006256 putative GKAP docking site [polypeptide binding]; other site 155864006257 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 155864006258 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 155864006259 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 155864006260 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 155864006261 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 155864006262 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 155864006263 MULE transposase domain; Region: MULE; pfam10551 155864006264 very similar to heat-stable toxin 1 (EAST1) but lacks codons for amino-terminal 8 aa 155864006265 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 155864006266 hypothetical protein; Provisional; Region: PHA03031 155864006267 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 155864006268 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 155864006269 dimer interface [polypeptide binding]; other site 155864006270 active site 155864006271 Int/Topo IB signature motif; other site 155864006272 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 155864006273 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 155864006274 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 155864006275 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 155864006276 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 155864006277 Phage-related protein, tail component [Function unknown]; Region: COG4733 155864006278 Putative phage tail protein; Region: Phage-tail_3; pfam13550 155864006279 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 155864006280 Interdomain contacts; other site 155864006281 Cytokine receptor motif; other site 155864006282 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 155864006283 Fibronectin type III protein; Region: DUF3672; pfam12421 155864006284 Phage-related protein, tail component [Function unknown]; Region: COG4733 155864006285 Putative phage tail protein; Region: Phage-tail_3; pfam13550 155864006286 Phage-related protein, tail component [Function unknown]; Region: COG4723 155864006287 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 155864006288 MPN+ (JAMM) motif; other site 155864006289 Zinc-binding site [ion binding]; other site 155864006290 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 155864006291 NlpC/P60 family; Region: NLPC_P60; cl17555 155864006292 Phage-related protein [Function unknown]; Region: gp18; COG4672 155864006293 Phage-related minor tail protein [Function unknown]; Region: COG5281 155864006294 tape measure domain; Region: tape_meas_nterm; TIGR02675 155864006295 Tail length tape measure protein; Region: Phage_HK97_TLTM; pfam06120 155864006296 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 155864006297 Protein of unknown function (DUF4035); Region: DUF4035; pfam13227 155864006298 Phage tail assembly chaperone; Region: Phage_TAC; pfam06222 155864006299 Immunoglobulin domain; Region: Ig_3; pfam13927 155864006300 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 155864006301 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 155864006302 Bacteriophage head-tail adaptor [General function prediction only]; Region: COG5614 155864006303 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 155864006304 zinc binding site [ion binding]; other site 155864006305 Phage-related protein [Function unknown]; Region: COG4695 155864006306 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 155864006307 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 155864006308 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 155864006309 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 155864006310 Phage capsid family; Region: Phage_capsid; pfam05065 155864006311 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 155864006312 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 155864006313 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 155864006314 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 155864006315 active site 155864006316 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 155864006317 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 155864006318 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 155864006319 ORF11CD3 domain; Region: ORF11CD3; pfam10549 155864006320 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 155864006321 catalytic residues [active] 155864006322 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 155864006323 Lysis protein S; Region: Lysis_S; pfam04971 155864006324 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 155864006325 Domain of unknown function (DUF303); Region: DUF303; pfam03629 155864006326 Protein of unknown function (DUF3927); Region: DUF3927; pfam13064 155864006327 tellurite resistance protein terB; Region: terB; cd07176 155864006328 putative metal binding site [ion binding]; other site 155864006329 Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323 155864006330 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 155864006331 Protein of unknown function (DUF968); Region: DUF968; pfam06147 155864006332 Hok/gef family; Region: HOK_GEF; pfam01848 155864006333 Protein of unknown function (DUF551); Region: DUF551; pfam04448 155864006334 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 155864006335 Protein of unknown function (DUF1627); Region: DUF1627; pfam07789 155864006336 putative replication protein; Provisional; Region: PRK12377 155864006337 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 155864006338 Walker A motif; other site 155864006339 ATP binding site [chemical binding]; other site 155864006340 Walker B motif; other site 155864006341 Helix-turn-helix domain; Region: HTH_36; pfam13730 155864006342 primosomal protein DnaI; Provisional; Region: PRK02854 155864006343 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 155864006344 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 155864006345 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 155864006346 sequence-specific DNA binding site [nucleotide binding]; other site 155864006347 salt bridge; other site 155864006348 transcriptional repressor DicA; Reviewed; Region: PRK09706 155864006349 DicB protein; Region: DicB; pfam05358 155864006350 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 155864006351 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 155864006352 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 155864006353 active site 155864006354 catalytic site [active] 155864006355 substrate binding site [chemical binding]; other site 155864006356 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 155864006357 O-island #71; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655; includes cryptic prophage CP-933P 155864006358 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 155864006359 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 155864006360 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 155864006361 hypothetical protein; Provisional; Region: PRK02237 155864006362 hypothetical protein; Provisional; Region: PRK13659 155864006363 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 155864006364 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 155864006365 Coenzyme A binding pocket [chemical binding]; other site 155864006366 Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788 155864006367 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 155864006368 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 155864006369 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 155864006370 putative [Fe4-S4] binding site [ion binding]; other site 155864006371 putative molybdopterin cofactor binding site [chemical binding]; other site 155864006372 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 155864006373 putative molybdopterin cofactor binding site; other site 155864006374 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 155864006375 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 155864006376 putative [Fe4-S4] binding site [ion binding]; other site 155864006377 putative molybdopterin cofactor binding site [chemical binding]; other site 155864006378 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 155864006379 putative molybdopterin cofactor binding site; other site 155864006380 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 155864006381 4Fe-4S binding domain; Region: Fer4; cl02805 155864006382 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 155864006383 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 155864006384 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 155864006385 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 155864006386 Cl- selectivity filter; other site 155864006387 Cl- binding residues [ion binding]; other site 155864006388 pore gating glutamate residue; other site 155864006389 dimer interface [polypeptide binding]; other site 155864006390 putative dithiobiotin synthetase; Provisional; Region: PRK12374 155864006391 AAA domain; Region: AAA_26; pfam13500 155864006392 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 155864006393 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 155864006394 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 155864006395 nucleotide binding site [chemical binding]; other site 155864006396 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 155864006397 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 155864006398 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 155864006399 dimerization interface [polypeptide binding]; other site 155864006400 substrate binding pocket [chemical binding]; other site 155864006401 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 155864006402 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864006403 putative substrate translocation pore; other site 155864006404 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 155864006405 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 155864006406 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 155864006407 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 155864006408 Domain of unknown function DUF20; Region: UPF0118; pfam01594 155864006409 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 155864006410 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 155864006411 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 155864006412 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 155864006413 ligand binding site [chemical binding]; other site 155864006414 homodimer interface [polypeptide binding]; other site 155864006415 NAD(P) binding site [chemical binding]; other site 155864006416 trimer interface B [polypeptide binding]; other site 155864006417 trimer interface A [polypeptide binding]; other site 155864006418 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 155864006419 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 155864006420 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 155864006421 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 155864006422 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 155864006423 Spore germination protein; Region: Spore_permease; cl17796 155864006424 dihydromonapterin reductase; Provisional; Region: PRK06483 155864006425 pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357 155864006426 NADP binding site [chemical binding]; other site 155864006427 substrate binding pocket [chemical binding]; other site 155864006428 active site 155864006429 GlpM protein; Region: GlpM; pfam06942 155864006430 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 155864006431 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 155864006432 active site 155864006433 phosphorylation site [posttranslational modification] 155864006434 intermolecular recognition site; other site 155864006435 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 155864006436 DNA binding site [nucleotide binding] 155864006437 sensor protein RstB; Provisional; Region: PRK10604 155864006438 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 155864006439 dimerization interface [polypeptide binding]; other site 155864006440 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 155864006441 dimer interface [polypeptide binding]; other site 155864006442 phosphorylation site [posttranslational modification] 155864006443 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 155864006444 ATP binding site [chemical binding]; other site 155864006445 Mg2+ binding site [ion binding]; other site 155864006446 G-X-G motif; other site 155864006447 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 155864006448 fumarate hydratase; Reviewed; Region: fumC; PRK00485 155864006449 Class II fumarases; Region: Fumarase_classII; cd01362 155864006450 active site 155864006451 tetramer interface [polypeptide binding]; other site 155864006452 fumarate hydratase; Provisional; Region: PRK15389 155864006453 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 155864006454 Fumarase C-terminus; Region: Fumerase_C; pfam05683 155864006455 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 155864006456 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 155864006457 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 155864006458 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 155864006459 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 155864006460 putative outer membrane porin protein; Provisional; Region: PRK11379 155864006461 putative outer membrane porin protein; Provisional; Region: PRK11379 155864006462 glucuronide transporter; Provisional; Region: PRK09848 155864006463 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 155864006464 beta-D-glucuronidase; Provisional; Region: PRK10150 155864006465 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 155864006466 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 155864006467 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 155864006468 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 155864006469 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 155864006470 7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113 155864006471 7 alpha-hydroxysteroid dehydrogenase (7 alpha-HSDH), classical (c) SDRs; Region: 7_alpha_HSDH_SDR_c; cd05365 155864006472 NAD binding site [chemical binding]; other site 155864006473 substrate binding site [chemical binding]; other site 155864006474 homotetramer interface [polypeptide binding]; other site 155864006475 homodimer interface [polypeptide binding]; other site 155864006476 active site 155864006477 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 155864006478 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 155864006479 DNA binding site [nucleotide binding] 155864006480 domain linker motif; other site 155864006481 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 155864006482 putative dimerization interface [polypeptide binding]; other site 155864006483 putative ligand binding site [chemical binding]; other site 155864006484 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 155864006485 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 155864006486 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 155864006487 active site turn [active] 155864006488 phosphorylation site [posttranslational modification] 155864006489 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 155864006490 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 155864006491 pyridoxal 5'-phosphate binding site [chemical binding]; other site 155864006492 homodimer interface [polypeptide binding]; other site 155864006493 catalytic residue [active] 155864006494 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 155864006495 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 155864006496 active site 155864006497 purine riboside binding site [chemical binding]; other site 155864006498 putative oxidoreductase; Provisional; Region: PRK11579 155864006499 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 155864006500 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 155864006501 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 155864006502 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 155864006503 electron transport complex protein RsxA; Provisional; Region: PRK05151 155864006504 ferredoxin; Provisional; Region: PRK08764 155864006505 Putative Fe-S cluster; Region: FeS; pfam04060 155864006506 4Fe-4S binding domain; Region: Fer4; pfam00037 155864006507 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 155864006508 SLBB domain; Region: SLBB; pfam10531 155864006509 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 155864006510 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 155864006511 electron transport complex protein RnfG; Validated; Region: PRK01908 155864006512 electron transport complex RsxE subunit; Provisional; Region: PRK12405 155864006513 endonuclease III; Provisional; Region: PRK10702 155864006514 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 155864006515 minor groove reading motif; other site 155864006516 helix-hairpin-helix signature motif; other site 155864006517 substrate binding pocket [chemical binding]; other site 155864006518 active site 155864006519 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 155864006520 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 155864006521 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864006522 putative substrate translocation pore; other site 155864006523 POT family; Region: PTR2; pfam00854 155864006524 glutathionine S-transferase; Provisional; Region: PRK10542 155864006525 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 155864006526 C-terminal domain interface [polypeptide binding]; other site 155864006527 GSH binding site (G-site) [chemical binding]; other site 155864006528 dimer interface [polypeptide binding]; other site 155864006529 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 155864006530 N-terminal domain interface [polypeptide binding]; other site 155864006531 dimer interface [polypeptide binding]; other site 155864006532 substrate binding pocket (H-site) [chemical binding]; other site 155864006533 pyridoxamine kinase; Validated; Region: PRK05756 155864006534 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 155864006535 dimer interface [polypeptide binding]; other site 155864006536 pyridoxal binding site [chemical binding]; other site 155864006537 ATP binding site [chemical binding]; other site 155864006538 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 155864006539 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 155864006540 active site 155864006541 HIGH motif; other site 155864006542 dimer interface [polypeptide binding]; other site 155864006543 KMSKS motif; other site 155864006544 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 155864006545 RNA binding surface [nucleotide binding]; other site 155864006546 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 155864006547 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 155864006548 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 155864006549 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 155864006550 Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702 155864006551 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 155864006552 transcriptional regulator SlyA; Provisional; Region: PRK03573 155864006553 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 155864006554 Protein of unknown function (DUF1656); Region: DUF1656; cl11658 155864006555 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 155864006556 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 155864006557 HlyD family secretion protein; Region: HlyD_3; pfam13437 155864006558 Fusaric acid resistance protein family; Region: FUSC; pfam04632 155864006559 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 155864006560 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 155864006561 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 155864006562 E-class dimer interface [polypeptide binding]; other site 155864006563 P-class dimer interface [polypeptide binding]; other site 155864006564 active site 155864006565 Cu2+ binding site [ion binding]; other site 155864006566 Zn2+ binding site [ion binding]; other site 155864006567 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 155864006568 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 155864006569 active site 155864006570 catalytic tetrad [active] 155864006571 Predicted Fe-S protein [General function prediction only]; Region: COG3313 155864006572 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 155864006573 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 155864006574 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 155864006575 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 155864006576 FMN binding site [chemical binding]; other site 155864006577 active site 155864006578 substrate binding site [chemical binding]; other site 155864006579 catalytic residue [active] 155864006580 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 155864006581 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 155864006582 dimer interface [polypeptide binding]; other site 155864006583 active site 155864006584 metal binding site [ion binding]; metal-binding site 155864006585 glutathione binding site [chemical binding]; other site 155864006586 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 155864006587 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 155864006588 dimer interface [polypeptide binding]; other site 155864006589 catalytic site [active] 155864006590 putative active site [active] 155864006591 putative substrate binding site [chemical binding]; other site 155864006592 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 155864006593 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 155864006594 ATP binding site [chemical binding]; other site 155864006595 putative Mg++ binding site [ion binding]; other site 155864006596 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 155864006597 nucleotide binding region [chemical binding]; other site 155864006598 ATP-binding site [chemical binding]; other site 155864006599 DEAD/H associated; Region: DEAD_assoc; pfam08494 155864006600 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 155864006601 putative GSH binding site [chemical binding]; other site 155864006602 catalytic residues [active] 155864006603 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 155864006604 NlpC/P60 family; Region: NLPC_P60; pfam00877 155864006605 superoxide dismutase; Provisional; Region: PRK10543 155864006606 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 155864006607 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 155864006608 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864006609 Major Facilitator Superfamily; Region: MFS_1; pfam07690 155864006610 putative substrate translocation pore; other site 155864006611 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 155864006612 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 155864006613 DNA binding site [nucleotide binding] 155864006614 domain linker motif; other site 155864006615 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 155864006616 dimerization interface [polypeptide binding]; other site 155864006617 ligand binding site [chemical binding]; other site 155864006618 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 155864006619 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 155864006620 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 155864006621 dimerization interface [polypeptide binding]; other site 155864006622 putative transporter; Provisional; Region: PRK11043 155864006623 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864006624 putative substrate translocation pore; other site 155864006625 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 155864006626 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 155864006627 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 155864006628 S-adenosylmethionine binding site [chemical binding]; other site 155864006629 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 155864006630 Lumazine binding domain; Region: Lum_binding; pfam00677 155864006631 Lumazine binding domain; Region: Lum_binding; pfam00677 155864006632 multidrug efflux protein; Reviewed; Region: PRK01766 155864006633 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 155864006634 cation binding site [ion binding]; other site 155864006635 hypothetical protein; Provisional; Region: PRK09945 155864006636 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 155864006637 putative monooxygenase; Provisional; Region: PRK11118 155864006638 hypothetical protein; Provisional; Region: PRK09897 155864006639 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 155864006640 hypothetical protein; Provisional; Region: PRK09946 155864006641 thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006 155864006642 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 155864006643 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 155864006644 hypothetical protein; Provisional; Region: PRK09947 155864006645 putative oxidoreductase; Provisional; Region: PRK09849 155864006646 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 155864006647 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 155864006648 hypothetical protein; Provisional; Region: PRK09898 155864006649 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 155864006650 hypothetical protein; Provisional; Region: PRK10292 155864006651 pyruvate kinase; Provisional; Region: PRK09206 155864006652 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 155864006653 domain interfaces; other site 155864006654 active site 155864006655 murein lipoprotein; Provisional; Region: PRK15396 155864006656 L,D-transpeptidase; Provisional; Region: PRK10190 155864006657 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 155864006658 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 155864006659 cysteine desufuration protein SufE; Provisional; Region: PRK09296 155864006660 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 155864006661 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 155864006662 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 155864006663 catalytic residue [active] 155864006664 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 155864006665 FeS assembly protein SufD; Region: sufD; TIGR01981 155864006666 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 155864006667 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 155864006668 Walker A/P-loop; other site 155864006669 ATP binding site [chemical binding]; other site 155864006670 Q-loop/lid; other site 155864006671 ABC transporter signature motif; other site 155864006672 Walker B; other site 155864006673 D-loop; other site 155864006674 H-loop/switch region; other site 155864006675 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 155864006676 putative ABC transporter; Region: ycf24; CHL00085 155864006677 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 155864006678 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 155864006679 CoenzymeA binding site [chemical binding]; other site 155864006680 subunit interaction site [polypeptide binding]; other site 155864006681 PHB binding site; other site 155864006682 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 155864006683 FAD binding domain; Region: FAD_binding_4; pfam01565 155864006684 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 155864006685 putative inner membrane protein; Provisional; Region: PRK10983 155864006686 Domain of unknown function DUF20; Region: UPF0118; pfam01594 155864006687 Domain of unknown function (DUF1870); Region: DUF1870; pfam08965 155864006688 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864006689 Major Facilitator Superfamily; Region: MFS_1; pfam07690 155864006690 putative substrate translocation pore; other site 155864006691 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864006692 putative substrate translocation pore; other site 155864006693 quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749 155864006694 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 155864006695 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 155864006696 shikimate binding site; other site 155864006697 NAD(P) binding site [chemical binding]; other site 155864006698 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 155864006699 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 155864006700 active site 155864006701 catalytic residue [active] 155864006702 dimer interface [polypeptide binding]; other site 155864006703 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 155864006704 Coenzyme A transferase; Region: CoA_trans; smart00882 155864006705 Coenzyme A transferase; Region: CoA_trans; cl17247 155864006706 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 155864006707 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 155864006708 active site 155864006709 Cupin domain; Region: Cupin_2; pfam07883 155864006710 Winged helix DNA-binding domain (DUF1495); Region: DUF1495; cl01336 155864006711 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 155864006712 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 155864006713 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 155864006714 Ligand binding site [chemical binding]; other site 155864006715 Electron transfer flavoprotein domain; Region: ETF; pfam01012 155864006716 electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916 155864006717 Electron transfer flavoprotein domain; Region: ETF; smart00893 155864006718 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 155864006719 oxidoreductase; Provisional; Region: PRK10015 155864006720 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 155864006721 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 155864006722 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 155864006723 acyl-activating enzyme (AAE) consensus motif; other site 155864006724 putative AMP binding site [chemical binding]; other site 155864006725 putative active site [active] 155864006726 putative CoA binding site [chemical binding]; other site 155864006727 phosphoenolpyruvate synthase; Validated; Region: PRK06464 155864006728 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 155864006729 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 155864006730 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 155864006731 PEP synthetase regulatory protein; Provisional; Region: PRK05339 155864006732 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 155864006733 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 155864006734 Hemin uptake protein [Inorganic ion transport and metabolism]; Region: HemP; COG4256 155864006735 Uncharacterized conserved protein [Function unknown]; Region: COG0397 155864006736 hypothetical protein; Validated; Region: PRK00029 155864006737 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 155864006738 NlpC/P60 family; Region: NLPC_P60; pfam00877 155864006739 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 155864006740 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 155864006741 Walker A/P-loop; other site 155864006742 ATP binding site [chemical binding]; other site 155864006743 Q-loop/lid; other site 155864006744 ABC transporter signature motif; other site 155864006745 Walker B; other site 155864006746 D-loop; other site 155864006747 H-loop/switch region; other site 155864006748 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 155864006749 catalytic residues [active] 155864006750 dimer interface [polypeptide binding]; other site 155864006751 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 155864006752 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 155864006753 ABC-ATPase subunit interface; other site 155864006754 dimer interface [polypeptide binding]; other site 155864006755 putative PBP binding regions; other site 155864006756 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 155864006757 IHF dimer interface [polypeptide binding]; other site 155864006758 IHF - DNA interface [nucleotide binding]; other site 155864006759 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 155864006760 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 155864006761 putative tRNA-binding site [nucleotide binding]; other site 155864006762 B3/4 domain; Region: B3_4; pfam03483 155864006763 tRNA synthetase B5 domain; Region: B5; smart00874 155864006764 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 155864006765 dimer interface [polypeptide binding]; other site 155864006766 motif 1; other site 155864006767 motif 3; other site 155864006768 motif 2; other site 155864006769 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 155864006770 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 155864006771 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 155864006772 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 155864006773 dimer interface [polypeptide binding]; other site 155864006774 motif 1; other site 155864006775 active site 155864006776 motif 2; other site 155864006777 motif 3; other site 155864006778 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 155864006779 23S rRNA binding site [nucleotide binding]; other site 155864006780 L21 binding site [polypeptide binding]; other site 155864006781 L13 binding site [polypeptide binding]; other site 155864006782 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 155864006783 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 155864006784 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 155864006785 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 155864006786 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 155864006787 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 155864006788 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 155864006789 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 155864006790 active site 155864006791 dimer interface [polypeptide binding]; other site 155864006792 motif 1; other site 155864006793 motif 2; other site 155864006794 motif 3; other site 155864006795 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 155864006796 anticodon binding site; other site 155864006797 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 155864006798 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 155864006799 6-phosphofructokinase 2; Provisional; Region: PRK10294 155864006800 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 155864006801 putative substrate binding site [chemical binding]; other site 155864006802 putative ATP binding site [chemical binding]; other site 155864006803 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 155864006804 Phosphotransferase enzyme family; Region: APH; pfam01636 155864006805 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 155864006806 active site 155864006807 ATP binding site [chemical binding]; other site 155864006808 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 155864006809 YniB-like protein; Region: YniB; pfam14002 155864006810 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 155864006811 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 155864006812 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 155864006813 motif II; other site 155864006814 inner membrane protein; Provisional; Region: PRK11648 155864006815 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 155864006816 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 155864006817 cell division modulator; Provisional; Region: PRK10113 155864006818 hydroperoxidase II; Provisional; Region: katE; PRK11249 155864006819 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 155864006820 tetramer interface [polypeptide binding]; other site 155864006821 heme binding pocket [chemical binding]; other site 155864006822 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 155864006823 domain interactions; other site 155864006824 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 155864006825 putative active site [active] 155864006826 YdjC motif; other site 155864006827 Mg binding site [ion binding]; other site 155864006828 putative homodimer interface [polypeptide binding]; other site 155864006829 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 155864006830 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 155864006831 NAD binding site [chemical binding]; other site 155864006832 sugar binding site [chemical binding]; other site 155864006833 divalent metal binding site [ion binding]; other site 155864006834 tetramer (dimer of dimers) interface [polypeptide binding]; other site 155864006835 dimer interface [polypeptide binding]; other site 155864006836 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 155864006837 Cupin domain; Region: Cupin_2; pfam07883 155864006838 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 155864006839 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 155864006840 methionine cluster; other site 155864006841 active site 155864006842 phosphorylation site [posttranslational modification] 155864006843 metal binding site [ion binding]; metal-binding site 155864006844 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 155864006845 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 155864006846 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 155864006847 active site 155864006848 P-loop; other site 155864006849 phosphorylation site [posttranslational modification] 155864006850 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 155864006851 NAD+ synthetase; Region: nadE; TIGR00552 155864006852 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 155864006853 homodimer interface [polypeptide binding]; other site 155864006854 NAD binding pocket [chemical binding]; other site 155864006855 ATP binding pocket [chemical binding]; other site 155864006856 Mg binding site [ion binding]; other site 155864006857 active-site loop [active] 155864006858 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 155864006859 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 155864006860 GIY-YIG motif/motif A; other site 155864006861 active site 155864006862 catalytic site [active] 155864006863 putative DNA binding site [nucleotide binding]; other site 155864006864 metal binding site [ion binding]; metal-binding site 155864006865 hypothetical protein; Provisional; Region: PRK11396 155864006866 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 155864006867 dimer interface [polypeptide binding]; other site 155864006868 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 155864006869 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 155864006870 putative active site [active] 155864006871 Zn binding site [ion binding]; other site 155864006872 succinylarginine dihydrolase; Provisional; Region: PRK13281 155864006873 succinylglutamic semialdehyde dehydrogenase; Region: arg_catab_astD; TIGR03240 155864006874 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 155864006875 NAD(P) binding site [chemical binding]; other site 155864006876 catalytic residues [active] 155864006877 arginine succinyltransferase; Provisional; Region: PRK10456 155864006878 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 155864006879 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 155864006880 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 155864006881 inhibitor-cofactor binding pocket; inhibition site 155864006882 pyridoxal 5'-phosphate binding site [chemical binding]; other site 155864006883 catalytic residue [active] 155864006884 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 155864006885 putative catalytic site [active] 155864006886 putative phosphate binding site [ion binding]; other site 155864006887 active site 155864006888 metal binding site A [ion binding]; metal-binding site 155864006889 DNA binding site [nucleotide binding] 155864006890 putative AP binding site [nucleotide binding]; other site 155864006891 putative metal binding site B [ion binding]; other site 155864006892 Uncharacterized conserved protein [Function unknown]; Region: COG0398 155864006893 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 155864006894 Uncharacterized conserved protein [Function unknown]; Region: COG0398 155864006895 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 155864006896 Uncharacterized conserved protein [Function unknown]; Region: COG2128 155864006897 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 155864006898 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 155864006899 hypothetical protein; Provisional; Region: PRK11622 155864006900 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135 155864006901 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 155864006902 dimer interface [polypeptide binding]; other site 155864006903 conserved gate region; other site 155864006904 putative PBP binding loops; other site 155864006905 ABC-ATPase subunit interface; other site 155864006906 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 155864006907 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 155864006908 Walker A/P-loop; other site 155864006909 ATP binding site [chemical binding]; other site 155864006910 Q-loop/lid; other site 155864006911 ABC transporter signature motif; other site 155864006912 Walker B; other site 155864006913 D-loop; other site 155864006914 H-loop/switch region; other site 155864006915 Rhodanese Homology Domain; Region: RHOD; smart00450 155864006916 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 155864006917 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 155864006918 active site residue [active] 155864006919 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 155864006920 active site residue [active] 155864006921 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 155864006922 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 155864006923 active site 155864006924 8-oxo-dGMP binding site [chemical binding]; other site 155864006925 nudix motif; other site 155864006926 metal binding site [ion binding]; metal-binding site 155864006927 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 155864006928 glutamate dehydrogenase; Provisional; Region: PRK09414 155864006929 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 155864006930 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 155864006931 NAD(P) binding site [chemical binding]; other site 155864006932 hypothetical protein; Provisional; Region: PRK11380 155864006933 DNA topoisomerase III; Provisional; Region: PRK07726 155864006934 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 155864006935 active site 155864006936 putative interdomain interaction site [polypeptide binding]; other site 155864006937 putative metal-binding site [ion binding]; other site 155864006938 putative nucleotide binding site [chemical binding]; other site 155864006939 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 155864006940 domain I; other site 155864006941 DNA binding groove [nucleotide binding] 155864006942 phosphate binding site [ion binding]; other site 155864006943 domain II; other site 155864006944 domain III; other site 155864006945 nucleotide binding site [chemical binding]; other site 155864006946 catalytic site [active] 155864006947 domain IV; other site 155864006948 selenophosphate synthetase; Provisional; Region: PRK00943 155864006949 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 155864006950 dimerization interface [polypeptide binding]; other site 155864006951 putative ATP binding site [chemical binding]; other site 155864006952 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 155864006953 putative FMN binding site [chemical binding]; other site 155864006954 protease 4; Provisional; Region: PRK10949 155864006955 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 155864006956 tandem repeat interface [polypeptide binding]; other site 155864006957 oligomer interface [polypeptide binding]; other site 155864006958 active site residues [active] 155864006959 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 155864006960 tandem repeat interface [polypeptide binding]; other site 155864006961 oligomer interface [polypeptide binding]; other site 155864006962 active site residues [active] 155864006963 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859 155864006964 Uncharacterized conserved protein [Function unknown]; Region: COG2968 155864006965 O-island #72; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864006966 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 155864006967 active site 155864006968 homodimer interface [polypeptide binding]; other site 155864006969 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 155864006970 Isochorismatase family; Region: Isochorismatase; pfam00857 155864006971 catalytic triad [active] 155864006972 metal binding site [ion binding]; metal-binding site 155864006973 conserved cis-peptide bond; other site 155864006974 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864006975 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864006976 O-island #73; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864006977 Transposase; Region: HTH_Tnp_1; cl17663 155864006978 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 155864006979 putative transposase OrfB; Reviewed; Region: PHA02517 155864006980 HTH-like domain; Region: HTH_21; pfam13276 155864006981 Integrase core domain; Region: rve; pfam00665 155864006982 Integrase core domain; Region: rve_3; pfam13683 155864006983 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 155864006984 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 155864006985 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 155864006986 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 155864006987 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 155864006988 active site 155864006989 catalytic tetrad [active] 155864006990 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 155864006991 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 155864006992 substrate binding site [chemical binding]; other site 155864006993 ATP binding site [chemical binding]; other site 155864006994 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 155864006995 intersubunit interface [polypeptide binding]; other site 155864006996 active site 155864006997 zinc binding site [ion binding]; other site 155864006998 Na+ binding site [ion binding]; other site 155864006999 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 155864007000 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 155864007001 inhibitor binding site; inhibition site 155864007002 catalytic Zn binding site [ion binding]; other site 155864007003 structural Zn binding site [ion binding]; other site 155864007004 NADP binding site [chemical binding]; other site 155864007005 tetramer interface [polypeptide binding]; other site 155864007006 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864007007 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864007008 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 155864007009 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 155864007010 putative NAD(P) binding site [chemical binding]; other site 155864007011 catalytic Zn binding site [ion binding]; other site 155864007012 structural Zn binding site [ion binding]; other site 155864007013 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 155864007014 methionine sulfoxide reductase B; Provisional; Region: PRK00222 155864007015 SelR domain; Region: SelR; pfam01641 155864007016 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 155864007017 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 155864007018 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 155864007019 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 155864007020 active site 155864007021 phosphate binding residues; other site 155864007022 catalytic residues [active] 155864007023 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 155864007024 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 155864007025 active site 155864007026 catalytic tetrad [active] 155864007027 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 155864007028 PrkA family serine protein kinase; Provisional; Region: PRK15455 155864007029 AAA ATPase domain; Region: AAA_16; pfam13191 155864007030 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 155864007031 hypothetical protein; Provisional; Region: PRK05325 155864007032 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 155864007033 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 155864007034 metal binding site [ion binding]; metal-binding site 155864007035 active site 155864007036 I-site; other site 155864007037 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 155864007038 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 155864007039 metal binding site [ion binding]; metal-binding site 155864007040 active site 155864007041 I-site; other site 155864007042 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 155864007043 putative deacylase active site [active] 155864007044 Predicted membrane protein [Function unknown]; Region: COG2707 155864007045 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 155864007046 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 155864007047 cyanate transporter; Region: CynX; TIGR00896 155864007048 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864007049 Uncharacterized conserved protein [Function unknown]; Region: COG3189 155864007050 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 155864007051 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 155864007052 Domain of unknown function (DUF333); Region: DUF333; pfam03891 155864007053 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 155864007054 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 155864007055 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 155864007056 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 155864007057 metal binding site [ion binding]; metal-binding site 155864007058 active site 155864007059 I-site; other site 155864007060 hypothetical protein; Provisional; Region: PRK10457 155864007061 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 155864007062 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 155864007063 leucine export protein LeuE; Provisional; Region: PRK10958 155864007064 transcriptional activator TtdR; Provisional; Region: PRK09801 155864007065 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 155864007066 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 155864007067 putative effector binding pocket; other site 155864007068 putative dimerization interface [polypeptide binding]; other site 155864007069 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 155864007070 tartrate dehydrogenase; Region: TTC; TIGR02089 155864007071 O-island #74; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864007072 O-island #74; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864007073 putative transporter; Provisional; Region: PRK09950 155864007074 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 155864007075 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 155864007076 [2Fe-2S] cluster binding site [ion binding]; other site 155864007077 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_2; cd08886 155864007078 putative alpha subunit interface [polypeptide binding]; other site 155864007079 putative active site [active] 155864007080 putative substrate binding site [chemical binding]; other site 155864007081 Fe binding site [ion binding]; other site 155864007082 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 155864007083 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 155864007084 FMN-binding pocket [chemical binding]; other site 155864007085 flavin binding motif; other site 155864007086 phosphate binding motif [ion binding]; other site 155864007087 beta-alpha-beta structure motif; other site 155864007088 NAD binding pocket [chemical binding]; other site 155864007089 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 155864007090 catalytic loop [active] 155864007091 iron binding site [ion binding]; other site 155864007092 ribonuclease D; Provisional; Region: PRK10829 155864007093 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 155864007094 catalytic site [active] 155864007095 putative active site [active] 155864007096 putative substrate binding site [chemical binding]; other site 155864007097 Helicase and RNase D C-terminal; Region: HRDC; smart00341 155864007098 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 155864007099 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 155864007100 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 155864007101 acyl-activating enzyme (AAE) consensus motif; other site 155864007102 putative AMP binding site [chemical binding]; other site 155864007103 putative active site [active] 155864007104 putative CoA binding site [chemical binding]; other site 155864007105 Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065 155864007106 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 155864007107 Glycoprotease family; Region: Peptidase_M22; pfam00814 155864007108 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 155864007109 DEAD/DEAH box helicase; Region: DEAD; pfam00270 155864007110 DEAD_2; Region: DEAD_2; pfam06733 155864007111 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 155864007112 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 155864007113 homotrimer interaction site [polypeptide binding]; other site 155864007114 putative active site [active] 155864007115 Domain of unknown function (DUF1889); Region: DUF1889; pfam08986 155864007116 hypothetical protein; Provisional; Region: PRK05114 155864007117 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 155864007118 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 155864007119 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 155864007120 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 155864007121 putative active site [active] 155864007122 putative CoA binding site [chemical binding]; other site 155864007123 nudix motif; other site 155864007124 metal binding site [ion binding]; metal-binding site 155864007125 L-serine deaminase; Provisional; Region: PRK15023 155864007126 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 155864007127 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 155864007128 phage resistance protein; Provisional; Region: PRK10551 155864007129 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 155864007130 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 155864007131 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 155864007132 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 155864007133 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 155864007134 Transporter associated domain; Region: CorC_HlyC; smart01091 155864007135 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 155864007136 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 155864007137 active pocket/dimerization site; other site 155864007138 active site 155864007139 phosphorylation site [posttranslational modification] 155864007140 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 155864007141 active site 155864007142 phosphorylation site [posttranslational modification] 155864007143 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 155864007144 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 155864007145 Predicted membrane protein [Function unknown]; Region: COG4811 155864007146 hypothetical protein; Provisional; Region: PRK11469 155864007147 Domain of unknown function DUF; Region: DUF204; pfam02659 155864007148 Domain of unknown function DUF; Region: DUF204; pfam02659 155864007149 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 155864007150 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 155864007151 S-adenosylmethionine binding site [chemical binding]; other site 155864007152 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 155864007153 DNA-binding site [nucleotide binding]; DNA binding site 155864007154 RNA-binding motif; other site 155864007155 Protein of unknown function (DUF2627); Region: DUF2527; pfam10736 155864007156 YebO-like protein; Region: YebO; pfam13974 155864007157 PhoPQ regulatory protein; Provisional; Region: PRK10299 155864007158 YobH-like protein; Region: YobH; pfam13996 155864007159 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 155864007160 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 155864007161 dimerization interface [polypeptide binding]; other site 155864007162 putative Zn2+ binding site [ion binding]; other site 155864007163 putative DNA binding site [nucleotide binding]; other site 155864007164 Bacterial transcriptional regulator; Region: IclR; pfam01614 155864007165 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864007166 Major Facilitator Superfamily; Region: MFS_1; pfam07690 155864007167 putative substrate translocation pore; other site 155864007168 Predicted integral membrane protein [Function unknown]; Region: COG5521 155864007169 heat shock protein HtpX; Provisional; Region: PRK05457 155864007170 carboxy-terminal protease; Provisional; Region: PRK11186 155864007171 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 155864007172 protein binding site [polypeptide binding]; other site 155864007173 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 155864007174 Catalytic dyad [active] 155864007175 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 155864007176 ProP expression regulator; Provisional; Region: PRK04950 155864007177 ProQ/FINO family; Region: ProQ; pfam04352 155864007178 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 155864007179 GAF domain; Region: GAF_2; pfam13185 155864007180 integral membrane protein, PqiA family; Region: pqiA_fam; TIGR00155 155864007181 Paraquat-inducible protein A; Region: PqiA; pfam04403 155864007182 Paraquat-inducible protein A; Region: PqiA; pfam04403 155864007183 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 155864007184 mce related protein; Region: MCE; pfam02470 155864007185 mce related protein; Region: MCE; pfam02470 155864007186 mce related protein; Region: MCE; pfam02470 155864007187 mce related protein; Region: MCE; pfam02470 155864007188 mce related protein; Region: MCE; pfam02470 155864007189 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 155864007190 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 155864007191 S-adenosylmethionine binding site [chemical binding]; other site 155864007192 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 155864007193 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 155864007194 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 155864007195 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 155864007196 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 155864007197 active site 155864007198 metal binding site [ion binding]; metal-binding site 155864007199 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 155864007200 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 155864007201 hypothetical protein; Provisional; Region: PRK10301 155864007202 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 155864007203 Predicted amidohydrolase [General function prediction only]; Region: COG0388 155864007204 Carbon-nitrogen hydrolase; Region: CN_hydrolase; pfam00795 155864007205 exodeoxyribonuclease X; Provisional; Region: PRK07983 155864007206 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 155864007207 active site 155864007208 catalytic site [active] 155864007209 substrate binding site [chemical binding]; other site 155864007210 protease 2; Provisional; Region: PRK10115 155864007211 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 155864007212 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 155864007213 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 155864007214 putative metal binding site [ion binding]; other site 155864007215 hypothetical protein; Provisional; Region: PRK13680 155864007216 DNA damage-inducible protein YebG; Provisional; Region: PRK10061 155864007217 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 155864007218 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 155864007219 ATP-grasp domain; Region: ATP-grasp; pfam02222 155864007220 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 155864007221 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 155864007222 active site 155864007223 intersubunit interface [polypeptide binding]; other site 155864007224 catalytic residue [active] 155864007225 phosphogluconate dehydratase; Validated; Region: PRK09054 155864007226 6-phosphogluconate dehydratase; Region: edd; TIGR01196 155864007227 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 155864007228 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 155864007229 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 155864007230 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 155864007231 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 155864007232 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 155864007233 putative active site [active] 155864007234 pyruvate kinase; Provisional; Region: PRK05826 155864007235 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 155864007236 domain interfaces; other site 155864007237 active site 155864007238 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 155864007239 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 155864007240 putative acyl-acceptor binding pocket; other site 155864007241 putative peptidase; Provisional; Region: PRK11649 155864007242 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 155864007243 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 155864007244 Peptidase family M23; Region: Peptidase_M23; pfam01551 155864007245 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 155864007246 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 155864007247 metal binding site [ion binding]; metal-binding site 155864007248 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 155864007249 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 155864007250 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 155864007251 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 155864007252 ABC-ATPase subunit interface; other site 155864007253 dimer interface [polypeptide binding]; other site 155864007254 putative PBP binding regions; other site 155864007255 O-island #75; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864007256 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 155864007257 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 155864007258 Walker A motif; other site 155864007259 ATP binding site [chemical binding]; other site 155864007260 Walker B motif; other site 155864007261 arginine finger; other site 155864007262 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 155864007263 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 155864007264 RuvA N terminal domain; Region: RuvA_N; pfam01330 155864007265 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 155864007266 hypothetical protein; Provisional; Region: PRK11470 155864007267 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 155864007268 active site 155864007269 putative DNA-binding cleft [nucleotide binding]; other site 155864007270 dimer interface [polypeptide binding]; other site 155864007271 hypothetical protein; Validated; Region: PRK00110 155864007272 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 155864007273 nudix motif; other site 155864007274 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 155864007275 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 155864007276 dimer interface [polypeptide binding]; other site 155864007277 anticodon binding site; other site 155864007278 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 155864007279 homodimer interface [polypeptide binding]; other site 155864007280 motif 1; other site 155864007281 active site 155864007282 motif 2; other site 155864007283 GAD domain; Region: GAD; pfam02938 155864007284 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 155864007285 motif 3; other site 155864007286 Isochorismatase family; Region: Isochorismatase; pfam00857 155864007287 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 155864007288 catalytic triad [active] 155864007289 conserved cis-peptide bond; other site 155864007290 hypothetical protein; Provisional; Region: PRK10302 155864007291 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 155864007292 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 155864007293 S-adenosylmethionine binding site [chemical binding]; other site 155864007294 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 155864007295 S-adenosylmethionine binding site [chemical binding]; other site 155864007296 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 155864007297 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 155864007298 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 155864007299 molybdopterin cofactor binding site [chemical binding]; other site 155864007300 substrate binding site [chemical binding]; other site 155864007301 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 155864007302 molybdopterin cofactor binding site; other site 155864007303 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 155864007304 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 155864007305 copper homeostasis protein CutC; Provisional; Region: PRK11572 155864007306 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 155864007307 putative metal binding site [ion binding]; other site 155864007308 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 155864007309 arginyl-tRNA synthetase; Region: argS; TIGR00456 155864007310 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 155864007311 active site 155864007312 HIGH motif; other site 155864007313 KMSK motif region; other site 155864007314 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 155864007315 tRNA binding surface [nucleotide binding]; other site 155864007316 anticodon binding site; other site 155864007317 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 155864007318 Flagellar protein FlhE; Region: FlhE; pfam06366 155864007319 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 155864007320 FHIPEP family; Region: FHIPEP; pfam00771 155864007321 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 155864007322 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 155864007323 chemotaxis regulator CheZ; Provisional; Region: PRK11166 155864007324 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 155864007325 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 155864007326 active site 155864007327 phosphorylation site [posttranslational modification] 155864007328 intermolecular recognition site; other site 155864007329 dimerization interface [polypeptide binding]; other site 155864007330 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 155864007331 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 155864007332 active site 155864007333 phosphorylation site [posttranslational modification] 155864007334 intermolecular recognition site; other site 155864007335 dimerization interface [polypeptide binding]; other site 155864007336 CheB methylesterase; Region: CheB_methylest; pfam01339 155864007337 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 155864007338 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 155864007339 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 155864007340 S-adenosylmethionine binding site [chemical binding]; other site 155864007341 methyl-accepting protein IV; Provisional; Region: PRK09793 155864007342 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 155864007343 dimer interface [polypeptide binding]; other site 155864007344 ligand binding site [chemical binding]; other site 155864007345 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 155864007346 dimerization interface [polypeptide binding]; other site 155864007347 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 155864007348 dimer interface [polypeptide binding]; other site 155864007349 putative CheW interface [polypeptide binding]; other site 155864007350 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 155864007351 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 155864007352 dimer interface [polypeptide binding]; other site 155864007353 ligand binding site [chemical binding]; other site 155864007354 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 155864007355 dimerization interface [polypeptide binding]; other site 155864007356 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 155864007357 dimer interface [polypeptide binding]; other site 155864007358 putative CheW interface [polypeptide binding]; other site 155864007359 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 155864007360 putative CheA interaction surface; other site 155864007361 chemotaxis protein CheA; Provisional; Region: PRK10547 155864007362 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 155864007363 putative binding surface; other site 155864007364 active site 155864007365 CheY binding; Region: CheY-binding; pfam09078 155864007366 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 155864007367 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 155864007368 ATP binding site [chemical binding]; other site 155864007369 Mg2+ binding site [ion binding]; other site 155864007370 G-X-G motif; other site 155864007371 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 155864007372 flagellar motor protein MotB; Validated; Region: motB; PRK09041 155864007373 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 155864007374 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 155864007375 ligand binding site [chemical binding]; other site 155864007376 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 155864007377 flagellar motor protein MotA; Validated; Region: PRK09110 155864007378 transcriptional activator FlhC; Provisional; Region: PRK12722 155864007379 transcriptional activator FlhD; Provisional; Region: PRK02909 155864007380 similar to hypothetical protein; No significant matches 155864007381 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 155864007382 Ligand Binding Site [chemical binding]; other site 155864007383 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 155864007384 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 155864007385 active site 155864007386 homotetramer interface [polypeptide binding]; other site 155864007387 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187 155864007388 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 155864007389 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 155864007390 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 155864007391 TM-ABC transporter signature motif; other site 155864007392 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 155864007393 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 155864007394 Walker A/P-loop; other site 155864007395 ATP binding site [chemical binding]; other site 155864007396 Q-loop/lid; other site 155864007397 ABC transporter signature motif; other site 155864007398 Walker B; other site 155864007399 D-loop; other site 155864007400 H-loop/switch region; other site 155864007401 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 155864007402 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 155864007403 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 155864007404 ligand binding site [chemical binding]; other site 155864007405 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 155864007406 Ferritin-like domain; Region: Ferritin; pfam00210 155864007407 ferroxidase diiron center [ion binding]; other site 155864007408 YecR-like lipoprotein; Region: YecR; pfam13992 155864007409 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 155864007410 Ferritin-like domain; Region: Ferritin; pfam00210 155864007411 ferroxidase diiron center [ion binding]; other site 155864007412 probable metal-binding protein; Region: matur_matur; TIGR03853 155864007413 tyrosine transporter TyrP; Provisional; Region: PRK15132 155864007414 aromatic amino acid transport protein; Region: araaP; TIGR00837 155864007415 hypothetical protein; Provisional; Region: PRK10396 155864007416 yecA family protein; Region: ygfB_yecA; TIGR02292 155864007417 SEC-C motif; Region: SEC-C; pfam02810 155864007418 O-island #76; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655; Cryptic prophage CP-933T; includes one copy of the 121 bp direct repeat that flanks the prophage 155864007419 integrase; Provisional; Region: int; PHA02601 155864007420 Phage HP1 integrase, C-terminal catalytic domain. Bacteriophage HP1 and related integrases are found in eubacteria, plasmids and temperate bacteriophages of the P2 family. They belong to the DNA breaking-rejoining enzyme superfamily, which includes...; Region: HP1_INT_C; cd00797 155864007421 dimer interface [polypeptide binding]; other site 155864007422 active site 155864007423 catalytic residues [active] 155864007424 Int/Topo IB signature motif; other site 155864007425 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 155864007426 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 155864007427 O-island #76; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655; Cryptic prophage CP-933T; includes one copy of the 121 bp direct repeat that flanks the prophage 155864007428 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 155864007429 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 155864007430 Mg binding site [ion binding]; other site 155864007431 nucleotide binding site [chemical binding]; other site 155864007432 putative protofilament interface [polypeptide binding]; other site 155864007433 Plasmid stability protein; Region: Plasmid_stab_B; pfam10784 155864007434 HTH-like domain; Region: HTH_21; pfam13276 155864007435 Integrase core domain; Region: rve; pfam00665 155864007436 Transposase; Region: HTH_Tnp_1; cl17663 155864007437 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 155864007438 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 155864007439 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 155864007440 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 155864007441 trimer interface [polypeptide binding]; other site 155864007442 active site 155864007443 substrate binding site [chemical binding]; other site 155864007444 CoA binding site [chemical binding]; other site 155864007445 Phage protein U [General function prediction only]; Region: COG3499 155864007446 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 155864007447 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 155864007448 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 155864007449 Phage tail tube protein FII [General function prediction only]; Region: COG3498 155864007450 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 155864007451 O-island #76; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655; Cryptic prophage CP-933T; includes one copy of the 121 bp direct repeat that flanks the prophage 155864007452 Phage protein D [General function prediction only]; Region: COG3500 155864007453 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 155864007454 DNA-binding interface [nucleotide binding]; DNA binding site 155864007455 Helix-turn-helix domain; Region: HTH_38; pfam13936 155864007456 Homeodomain-like domain; Region: HTH_32; pfam13565 155864007457 Integrase core domain; Region: rve; pfam00665 155864007458 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 155864007459 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 155864007460 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 155864007461 GIY-YIG motif/motif A; other site 155864007462 active site 155864007463 catalytic site [active] 155864007464 putative DNA binding site [nucleotide binding]; other site 155864007465 metal binding site [ion binding]; metal-binding site 155864007466 UvrB/uvrC motif; Region: UVR; pfam02151 155864007467 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 155864007468 Helix-hairpin-helix motif; Region: HHH; pfam00633 155864007469 response regulator; Provisional; Region: PRK09483 155864007470 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 155864007471 active site 155864007472 phosphorylation site [posttranslational modification] 155864007473 intermolecular recognition site; other site 155864007474 dimerization interface [polypeptide binding]; other site 155864007475 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 155864007476 DNA binding residues [nucleotide binding] 155864007477 dimerization interface [polypeptide binding]; other site 155864007478 hypothetical protein; Provisional; Region: PRK10613 155864007479 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 155864007480 Autoinducer binding domain; Region: Autoind_bind; pfam03472 155864007481 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 155864007482 DNA binding residues [nucleotide binding] 155864007483 dimerization interface [polypeptide binding]; other site 155864007484 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 155864007485 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 155864007486 Walker A/P-loop; other site 155864007487 ATP binding site [chemical binding]; other site 155864007488 Q-loop/lid; other site 155864007489 ABC transporter signature motif; other site 155864007490 Walker B; other site 155864007491 D-loop; other site 155864007492 H-loop/switch region; other site 155864007493 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 155864007494 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 155864007495 dimer interface [polypeptide binding]; other site 155864007496 conserved gate region; other site 155864007497 putative PBP binding loops; other site 155864007498 ABC-ATPase subunit interface; other site 155864007499 D-cysteine desulfhydrase; Validated; Region: PRK03910 155864007500 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 155864007501 pyridoxal 5'-phosphate binding site [chemical binding]; other site 155864007502 catalytic residue [active] 155864007503 cystine transporter subunit; Provisional; Region: PRK11260 155864007504 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 155864007505 substrate binding pocket [chemical binding]; other site 155864007506 membrane-bound complex binding site; other site 155864007507 hinge residues; other site 155864007508 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 155864007509 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 155864007510 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 155864007511 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 155864007512 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 155864007513 DNA binding residues [nucleotide binding] 155864007514 flagellin; Validated; Region: PRK08026 155864007515 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 155864007516 Flagellin protein; Region: FliC; pfam12445 155864007517 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 155864007518 flagellar capping protein; Reviewed; Region: fliD; PRK08032 155864007519 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 155864007520 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 155864007521 Flagellar protein FliS; Region: FliS; cl00654 155864007522 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 155864007523 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 155864007524 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 155864007525 active site 155864007526 Na/Ca binding site [ion binding]; other site 155864007527 catalytic site [active] 155864007528 lipoprotein; Provisional; Region: PRK10397 155864007529 putative inner membrane protein; Provisional; Region: PRK11099 155864007530 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 155864007531 CPxP motif; other site 155864007532 hypothetical protein; Provisional; Region: PRK09951 155864007533 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 155864007534 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 155864007535 Coenzyme A binding pocket [chemical binding]; other site 155864007536 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 155864007537 O-island #77; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864007538 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 155864007539 Coenzyme A binding pocket [chemical binding]; other site 155864007540 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 155864007541 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 155864007542 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 155864007543 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 155864007544 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 155864007545 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 155864007546 flagellar motor switch protein FliG; Region: fliG; TIGR00207 155864007547 FliG C-terminal domain; Region: FliG_C; pfam01706 155864007548 flagellar assembly protein H; Validated; Region: fliH; PRK05687 155864007549 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 155864007550 Flagellar assembly protein FliH; Region: FliH; pfam02108 155864007551 O-island #78; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864007552 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 155864007553 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 155864007554 Walker A motif/ATP binding site; other site 155864007555 Walker B motif; other site 155864007556 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 155864007557 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 155864007558 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 155864007559 flagellar hook-length control protein; Provisional; Region: PRK10118 155864007560 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 155864007561 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 155864007562 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 155864007563 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 155864007564 flagellar motor switch protein; Validated; Region: fliN; PRK05698 155864007565 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 155864007566 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 155864007567 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 155864007568 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 155864007569 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 155864007570 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 155864007571 DNA binding residues [nucleotide binding] 155864007572 dimerization interface [polypeptide binding]; other site 155864007573 hypothetical protein; Provisional; Region: PRK10708 155864007574 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 155864007575 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 155864007576 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 155864007577 active site 155864007578 motif I; other site 155864007579 motif II; other site 155864007580 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 155864007581 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 155864007582 metal binding site [ion binding]; metal-binding site 155864007583 active site 155864007584 I-site; other site 155864007585 Uncharacterized small protein [Function unknown]; Region: COG5475 155864007586 hypothetical protein; Provisional; Region: PRK10062 155864007587 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 155864007588 EamA-like transporter family; Region: EamA; pfam00892 155864007589 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 155864007590 additional DNA contacts [nucleotide binding]; other site 155864007591 mismatch recognition site; other site 155864007592 active site 155864007593 zinc binding site [ion binding]; other site 155864007594 DNA intercalation site [nucleotide binding]; other site 155864007595 DNA cytosine methylase; Provisional; Region: PRK10458 155864007596 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 155864007597 cofactor binding site; other site 155864007598 DNA binding site [nucleotide binding] 155864007599 substrate interaction site [chemical binding]; other site 155864007600 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 155864007601 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 155864007602 Zn2+ binding site [ion binding]; other site 155864007603 Mg2+ binding site [ion binding]; other site 155864007604 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 155864007605 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 155864007606 trimer interface [polypeptide binding]; other site 155864007607 eyelet of channel; other site 155864007608 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 155864007609 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 155864007610 chaperone protein HchA; Provisional; Region: PRK04155 155864007611 Type 1 glutamine amidotransferase (GATase1)-like domain found in Escherichia coli Hsp31 protein (EcHsp31); Region: GATase1_EcHsp31_like; cd03148 155864007612 dimer interface [polypeptide binding]; other site 155864007613 metal binding site [ion binding]; metal-binding site 155864007614 potential oxyanion hole; other site 155864007615 potential catalytic triad [active] 155864007616 conserved cys residue [active] 155864007617 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 155864007618 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 155864007619 dimer interface [polypeptide binding]; other site 155864007620 phosphorylation site [posttranslational modification] 155864007621 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 155864007622 ATP binding site [chemical binding]; other site 155864007623 Mg2+ binding site [ion binding]; other site 155864007624 G-X-G motif; other site 155864007625 transcriptional regulatory protein YedW; Provisional; Region: PRK11517 155864007626 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 155864007627 active site 155864007628 phosphorylation site [posttranslational modification] 155864007629 intermolecular recognition site; other site 155864007630 dimerization interface [polypeptide binding]; other site 155864007631 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 155864007632 DNA binding site [nucleotide binding] 155864007633 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 155864007634 active site 155864007635 homotetramer interface [polypeptide binding]; other site 155864007636 TMAO/DMSO reductase; Reviewed; Region: PRK05363 155864007637 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 155864007638 Moco binding site; other site 155864007639 metal coordination site [ion binding]; other site 155864007640 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 155864007641 zinc/cadmium-binding protein; Provisional; Region: PRK10306 155864007642 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 155864007643 Cryptic prophage CP-933U; includes one copy of the 61 bp direct repeat that flanks the prophage; O-island #79; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864007644 AvrPphF-ORF-2; Region: AvrPphF-ORF-2; pfam09143 155864007645 EspF protein repeat; Region: EspF; pfam04806 155864007646 EspF protein repeat; Region: EspF; pfam04806 155864007647 EspF protein repeat; Region: EspF; pfam04806 155864007648 EspF protein repeat; Region: EspF; pfam04806 155864007649 EspF protein repeat; Region: EspF; pfam04806 155864007650 EspF protein repeat; Region: EspF; pfam04806 155864007651 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 155864007652 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 155864007653 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 155864007654 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 155864007655 Phage-related protein, tail component [Function unknown]; Region: COG4733 155864007656 Putative phage tail protein; Region: Phage-tail_3; pfam13550 155864007657 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 155864007658 Interdomain contacts; other site 155864007659 Cytokine receptor motif; other site 155864007660 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 155864007661 Fibronectin type III protein; Region: DUF3672; pfam12421 155864007662 Cryptic prophage CP-933U; includes one copy of the 61 bp direct repeat that flanks the prophage; O-island #79; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864007663 Phage-related protein, tail component [Function unknown]; Region: COG4723 155864007664 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 155864007665 MPN+ (JAMM) motif; other site 155864007666 Zinc-binding site [ion binding]; other site 155864007667 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 155864007668 NlpC/P60 family; Region: NLPC_P60; cl17555 155864007669 Phage-related protein [Function unknown]; Region: gp18; COG4672 155864007670 Phage-related protein [Function unknown]; Region: COG4718 155864007671 Phage-related minor tail protein [Function unknown]; Region: COG5281 155864007672 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 155864007673 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 155864007674 phage tail tape measure protein, lambda family; Region: tape_meas_lam_C; TIGR01541 155864007675 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 155864007676 phage tail assembly protein T; Region: phage_lam_T; TIGR01715 155864007677 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894 155864007678 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 155864007679 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 155864007680 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 155864007681 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 155864007682 ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; pfam13856 155864007683 Uncharacterized conserved protein [Function unknown]; Region: COG5471 155864007684 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 155864007685 Transposase; Region: HTH_Tnp_1; cl17663 155864007686 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 155864007687 putative transposase OrfB; Reviewed; Region: PHA02517 155864007688 HTH-like domain; Region: HTH_21; pfam13276 155864007689 Integrase core domain; Region: rve; pfam00665 155864007690 Integrase core domain; Region: rve_3; pfam13683 155864007691 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 155864007692 Clp protease; Region: CLP_protease; pfam00574 155864007693 oligomer interface [polypeptide binding]; other site 155864007694 active site residues [active] 155864007695 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 155864007696 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 155864007697 Cryptic prophage CP-933U; includes one copy of the 61 bp direct repeat that flanks the prophage; O-island #79; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864007698 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 155864007699 Protein of unknown function (DUF1441); Region: DUF1441; pfam07278 155864007700 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 155864007701 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 155864007702 ORF11CD3 domain; Region: ORF11CD3; pfam10549 155864007703 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 155864007704 catalytic residues [active] 155864007705 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 155864007706 Lysis protein S; Region: Lysis_S; pfam04971 155864007707 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 155864007708 Domain of unknown function (DUF303); Region: DUF303; pfam03629 155864007709 Protein of unknown function (DUF3927); Region: DUF3927; pfam13064 155864007710 tellurite resistance protein terB; Region: terB; cd07176 155864007711 putative metal binding site [ion binding]; other site 155864007712 Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323 155864007713 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 155864007714 Protein of unknown function (DUF968); Region: DUF968; pfam06147 155864007715 Cryptic prophage CP-933U; includes one copy of the 61 bp direct repeat that flanks the prophage; O-island #79; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864007716 Protein of unknown function (DUF1627); Region: DUF1627; pfam07789 155864007717 Pyocin large subunit [General function prediction only]; Region: COG5529 155864007718 primosomal protein DnaI; Provisional; Region: PRK02854 155864007719 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 155864007720 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 155864007721 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 155864007722 non-specific DNA binding site [nucleotide binding]; other site 155864007723 salt bridge; other site 155864007724 sequence-specific DNA binding site [nucleotide binding]; other site 155864007725 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 155864007726 Catalytic site [active] 155864007727 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 155864007728 DicB protein; Region: DicB; pfam05358 155864007729 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 155864007730 active site 155864007731 substrate binding site [chemical binding]; other site 155864007732 catalytic site [active] 155864007733 O-island #79; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864007734 Cryptic prophage CP-933U; includes one copy of the 61 bp direct repeat that flanks the prophage 155864007735 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 155864007736 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 155864007737 active site 155864007738 DNA binding site [nucleotide binding] 155864007739 Int/Topo IB signature motif; other site 155864007740 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 155864007741 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 155864007742 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 155864007743 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 155864007744 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 155864007745 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 155864007746 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 155864007747 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 155864007748 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 155864007749 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 155864007750 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 155864007751 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 155864007752 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 155864007753 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 155864007754 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 155864007755 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 155864007756 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 155864007757 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 155864007758 O-island #80; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864007759 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 155864007760 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 155864007761 shikimate transporter; Provisional; Region: PRK09952 155864007762 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864007763 putative substrate translocation pore; other site 155864007764 AMP nucleosidase; Provisional; Region: PRK08292 155864007765 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 155864007766 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 155864007767 hypothetical protein; Provisional; Region: PRK12378 155864007768 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 155864007769 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 155864007770 putative efflux protein, MATE family; Region: matE; TIGR00797 155864007771 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 155864007772 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 155864007773 The C-terminal substrate binding domain of LysR-type transcriptional regulator Cbl, which is required for expression of sulfate starvation-inducible (ssi) genes, contains the type 2 periplasmic binding fold; Region: PBP2_Cbl; cd08444 155864007774 putative substrate binding site [chemical binding]; other site 155864007775 dimerization interface [polypeptide binding]; other site 155864007776 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 155864007777 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 155864007778 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 155864007779 putative dimerization interface [polypeptide binding]; other site 155864007780 L,D-transpeptidase; Provisional; Region: PRK10190 155864007781 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 155864007782 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 155864007783 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 155864007784 putative dimer interface [polypeptide binding]; other site 155864007785 active site pocket [active] 155864007786 putative cataytic base [active] 155864007787 cobalamin 5'-phosphate synthase/cobalamin synthase; Region: cobS; TIGR00317 155864007788 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 155864007789 homotrimer interface [polypeptide binding]; other site 155864007790 Walker A motif; other site 155864007791 GTP binding site [chemical binding]; other site 155864007792 Walker B motif; other site 155864007793 O-island #81; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864007794 Transposase; Region: HTH_Tnp_1; pfam01527 155864007795 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 155864007796 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 155864007797 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 155864007798 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 155864007799 homodimer interface [polypeptide binding]; other site 155864007800 putative GKAP docking site [polypeptide binding]; other site 155864007801 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 155864007802 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 155864007803 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 155864007804 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 155864007805 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 155864007806 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 155864007807 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 155864007808 N-terminal plug; other site 155864007809 ligand-binding site [chemical binding]; other site 155864007810 O-island #82; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864007811 O-island #82; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864007812 Transposase; Region: HTH_Tnp_1; cl17663 155864007813 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 155864007814 putative transposase OrfB; Reviewed; Region: PHA02517 155864007815 HTH-like domain; Region: HTH_21; pfam13276 155864007816 Integrase core domain; Region: rve; pfam00665 155864007817 Integrase core domain; Region: rve_3; pfam13683 155864007818 Protein of unknown function (DUF987); Region: DUF987; pfam06174 155864007819 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 155864007820 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 155864007821 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 155864007822 Switch II region; other site 155864007823 G4 box; other site 155864007824 G5 box; other site 155864007825 hypothetical protein; Provisional; Region: PRK05423 155864007826 Predicted membrane protein [Function unknown]; Region: COG1289 155864007827 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 155864007828 DNA gyrase inhibitor; Provisional; Region: PRK10016 155864007829 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 155864007830 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 155864007831 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 155864007832 exonuclease I; Provisional; Region: sbcB; PRK11779 155864007833 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 155864007834 active site 155864007835 catalytic site [active] 155864007836 substrate binding site [chemical binding]; other site 155864007837 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 155864007838 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 155864007839 CPxP motif; other site 155864007840 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 155864007841 Sulphur transport; Region: Sulf_transp; pfam04143 155864007842 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 155864007843 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 155864007844 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 155864007845 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 155864007846 dimerization interface [polypeptide binding]; other site 155864007847 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 155864007848 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 155864007849 putative NAD(P) binding site [chemical binding]; other site 155864007850 O-island #83; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864007851 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 155864007852 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 155864007853 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 155864007854 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 155864007855 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 155864007856 NAD binding site [chemical binding]; other site 155864007857 dimerization interface [polypeptide binding]; other site 155864007858 product binding site; other site 155864007859 substrate binding site [chemical binding]; other site 155864007860 zinc binding site [ion binding]; other site 155864007861 catalytic residues [active] 155864007862 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 155864007863 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 155864007864 pyridoxal 5'-phosphate binding site [chemical binding]; other site 155864007865 homodimer interface [polypeptide binding]; other site 155864007866 catalytic residue [active] 155864007867 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 155864007868 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 155864007869 active site 155864007870 motif I; other site 155864007871 motif II; other site 155864007872 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 155864007873 putative active site pocket [active] 155864007874 4-fold oligomerization interface [polypeptide binding]; other site 155864007875 metal binding residues [ion binding]; metal-binding site 155864007876 3-fold/trimer interface [polypeptide binding]; other site 155864007877 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 155864007878 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 155864007879 putative active site [active] 155864007880 oxyanion strand; other site 155864007881 catalytic triad [active] 155864007882 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 155864007883 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 155864007884 catalytic residues [active] 155864007885 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 155864007886 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 155864007887 substrate binding site [chemical binding]; other site 155864007888 glutamase interaction surface [polypeptide binding]; other site 155864007889 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 155864007890 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 155864007891 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 155864007892 metal binding site [ion binding]; metal-binding site 155864007893 chain length determinant protein WzzB; Provisional; Region: PRK15471 155864007894 Chain length determinant protein; Region: Wzz; pfam02706 155864007895 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 155864007896 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 155864007897 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 155864007898 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 155864007899 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 155864007900 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 155864007901 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 155864007902 O-island #84; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864007903 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 155864007904 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 155864007905 putative trimer interface [polypeptide binding]; other site 155864007906 putative CoA binding site [chemical binding]; other site 155864007907 O-island #84; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864007908 phosphomannomutase CpsG; Provisional; Region: PRK15414 155864007909 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 155864007910 active site 155864007911 substrate binding site [chemical binding]; other site 155864007912 metal binding site [ion binding]; metal-binding site 155864007913 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 155864007914 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 155864007915 Substrate binding site; other site 155864007916 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 155864007917 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 155864007918 active site 155864007919 GDP-Mannose binding site [chemical binding]; other site 155864007920 dimer interface [polypeptide binding]; other site 155864007921 modified nudix motif 155864007922 metal binding site [ion binding]; metal-binding site 155864007923 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 155864007924 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 155864007925 NADP binding site [chemical binding]; other site 155864007926 active site 155864007927 putative substrate binding site [chemical binding]; other site 155864007928 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 155864007929 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 155864007930 NADP-binding site; other site 155864007931 homotetramer interface [polypeptide binding]; other site 155864007932 substrate binding site [chemical binding]; other site 155864007933 homodimer interface [polypeptide binding]; other site 155864007934 active site 155864007935 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 155864007936 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 155864007937 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 155864007938 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 155864007939 inhibitor-cofactor binding pocket; inhibition site 155864007940 pyridoxal 5'-phosphate binding site [chemical binding]; other site 155864007941 catalytic residue [active] 155864007942 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 155864007943 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 155864007944 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 155864007945 active site 155864007946 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 155864007947 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 155864007948 active site 155864007949 O-island #84; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864007950 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 155864007951 active site 155864007952 tetramer interface; other site 155864007953 O-island #85; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864007954 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 155864007955 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 155864007956 putative NAD(P) binding site [chemical binding]; other site 155864007957 active site 155864007958 putative substrate binding site [chemical binding]; other site 155864007959 putative colanic acid biosynthesis protein; Provisional; Region: wcaM; PRK10123 155864007960 colanic acid biosynthesis glycosyltransferase WcaL; Region: wcaL; TIGR04005 155864007961 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 155864007962 putative ADP-binding pocket [chemical binding]; other site 155864007963 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 155864007964 colanic acid biosynthesis pyruvyl transferase WcaK; Region: wcaK; TIGR04006 155864007965 colanic acid exporter; Provisional; Region: PRK10459 155864007966 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 155864007967 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 155864007968 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 155864007969 phosphomannomutase CpsG; Provisional; Region: PRK15414 155864007970 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 155864007971 active site 155864007972 substrate binding site [chemical binding]; other site 155864007973 metal binding site [ion binding]; metal-binding site 155864007974 O-island #86; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864007975 O-island #86; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864007976 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 155864007977 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 155864007978 Substrate binding site; other site 155864007979 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 155864007980 colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007 155864007981 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 155864007982 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 155864007983 active site 155864007984 GDP-Mannose binding site [chemical binding]; other site 155864007985 dimer interface [polypeptide binding]; other site 155864007986 modified nudix motif 155864007987 metal binding site [ion binding]; metal-binding site 155864007988 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 155864007989 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 155864007990 NADP binding site [chemical binding]; other site 155864007991 active site 155864007992 putative substrate binding site [chemical binding]; other site 155864007993 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 155864007994 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 155864007995 NADP-binding site; other site 155864007996 homotetramer interface [polypeptide binding]; other site 155864007997 substrate binding site [chemical binding]; other site 155864007998 homodimer interface [polypeptide binding]; other site 155864007999 active site 155864008000 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 155864008001 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 155864008002 putative trimer interface [polypeptide binding]; other site 155864008003 putative active site [active] 155864008004 putative substrate binding site [chemical binding]; other site 155864008005 putative CoA binding site [chemical binding]; other site 155864008006 putative glycosyl transferase; Provisional; Region: PRK10063 155864008007 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 155864008008 metal-binding site 155864008009 putative colanic acid polymerase WcaD; Region: WcaD; TIGR04010 155864008010 colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015 155864008011 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 155864008012 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 155864008013 putative acyl transferase; Provisional; Region: PRK10191 155864008014 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 155864008015 trimer interface [polypeptide binding]; other site 155864008016 active site 155864008017 substrate binding site [chemical binding]; other site 155864008018 CoA binding site [chemical binding]; other site 155864008019 putative glycosyl transferase; Provisional; Region: PRK10018 155864008020 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 155864008021 active site 155864008022 tyrosine kinase; Provisional; Region: PRK11519 155864008023 Chain length determinant protein; Region: Wzz; pfam02706 155864008024 Chain length determinant protein; Region: Wzz; cl15801 155864008025 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 155864008026 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 155864008027 Low molecular weight phosphatase family; Region: LMWPc; cd00115 155864008028 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 155864008029 active site 155864008030 polysaccharide export protein Wza; Provisional; Region: PRK15078 155864008031 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 155864008032 SLBB domain; Region: SLBB; pfam10531 155864008033 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 155864008034 FOG: CBS domain [General function prediction only]; Region: COG0517 155864008035 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 155864008036 Transporter associated domain; Region: CorC_HlyC; smart01091 155864008037 O-island #87; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864008038 Phage-related protein [Function unknown]; Region: COG4679 155864008039 Uncharacterized conserved small protein [Function unknown]; Region: COG5606 155864008040 putative assembly protein; Provisional; Region: PRK10833 155864008041 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 155864008042 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 155864008043 trimer interface [polypeptide binding]; other site 155864008044 active site 155864008045 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 155864008046 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 155864008047 ATP-binding site [chemical binding]; other site 155864008048 Sugar specificity; other site 155864008049 Pyrimidine base specificity; other site 155864008050 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 155864008051 putative diguanylate cyclase; Provisional; Region: PRK09776 155864008052 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 155864008053 putative active site [active] 155864008054 heme pocket [chemical binding]; other site 155864008055 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 155864008056 putative active site [active] 155864008057 heme pocket [chemical binding]; other site 155864008058 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 155864008059 putative active site [active] 155864008060 heme pocket [chemical binding]; other site 155864008061 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 155864008062 metal binding site [ion binding]; metal-binding site 155864008063 active site 155864008064 I-site; other site 155864008065 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 155864008066 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 155864008067 AlkA N-terminal domain; Region: AlkA_N; smart01009 155864008068 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 155864008069 minor groove reading motif; other site 155864008070 helix-hairpin-helix signature motif; other site 155864008071 substrate binding pocket [chemical binding]; other site 155864008072 active site 155864008073 putative chaperone; Provisional; Region: PRK11678 155864008074 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 155864008075 nucleotide binding site [chemical binding]; other site 155864008076 putative NEF/HSP70 interaction site [polypeptide binding]; other site 155864008077 SBD interface [polypeptide binding]; other site 155864008078 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248 155864008079 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 155864008080 substrate binding site [chemical binding]; other site 155864008081 activation loop (A-loop); other site 155864008082 Protein phosphatase 2C; Region: PP2C_2; pfam13672 155864008083 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 155864008084 metal ion-dependent adhesion site (MIDAS); other site 155864008085 O-island #88; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864008086 O-island #88; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864008087 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 155864008088 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 155864008089 HlyD family secretion protein; Region: HlyD_3; pfam13437 155864008090 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 155864008091 Protein export membrane protein; Region: SecD_SecF; cl14618 155864008092 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 155864008093 putative transporter; Provisional; Region: PRK10504 155864008094 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864008095 putative substrate translocation pore; other site 155864008096 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864008097 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 155864008098 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 155864008099 dimerization interface [polypeptide binding]; other site 155864008100 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 155864008101 dimer interface [polypeptide binding]; other site 155864008102 phosphorylation site [posttranslational modification] 155864008103 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 155864008104 ATP binding site [chemical binding]; other site 155864008105 Mg2+ binding site [ion binding]; other site 155864008106 G-X-G motif; other site 155864008107 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 155864008108 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 155864008109 active site 155864008110 phosphorylation site [posttranslational modification] 155864008111 intermolecular recognition site; other site 155864008112 dimerization interface [polypeptide binding]; other site 155864008113 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 155864008114 DNA binding site [nucleotide binding] 155864008115 Uncharacterized conserved protein [Function unknown]; Region: COG3422 155864008116 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 155864008117 putative protease; Provisional; Region: PRK15452 155864008118 Peptidase family U32; Region: Peptidase_U32; pfam01136 155864008119 lipid kinase; Reviewed; Region: PRK13054 155864008120 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 155864008121 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 155864008122 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 155864008123 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 155864008124 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 155864008125 putative NAD(P) binding site [chemical binding]; other site 155864008126 catalytic Zn binding site [ion binding]; other site 155864008127 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 155864008128 PTS system, galactitol-specific IIC component; Region: EIIC-GAT; TIGR00827 155864008129 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 155864008130 active site 155864008131 P-loop; other site 155864008132 phosphorylation site [posttranslational modification] 155864008133 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 155864008134 active site 155864008135 phosphorylation site [posttranslational modification] 155864008136 D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052 155864008137 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 155864008138 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 155864008139 intersubunit interface [polypeptide binding]; other site 155864008140 active site 155864008141 zinc binding site [ion binding]; other site 155864008142 Na+ binding site [ion binding]; other site 155864008143 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 155864008144 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 155864008145 putative active site; other site 155864008146 catalytic residue [active] 155864008147 nucleoside transporter; Region: 2A0110; TIGR00889 155864008148 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864008149 putative substrate translocation pore; other site 155864008150 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 155864008151 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 155864008152 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 155864008153 substrate binding site [chemical binding]; other site 155864008154 ATP binding site [chemical binding]; other site 155864008155 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 155864008156 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 155864008157 DNA-binding site [nucleotide binding]; DNA binding site 155864008158 UTRA domain; Region: UTRA; pfam07702 155864008159 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 155864008160 YegX is an uncharacterized bacterial protein with a glycosyl hydrolase family 25 (GH25) catalytic domain that is similar in sequence to the CH-type (Chalaropsis-type) lysozymes of the GH25 family of endolysins; Region: GH25_YegX-like; cd06524 155864008161 active site 155864008162 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 155864008163 dimer interface [polypeptide binding]; other site 155864008164 substrate binding site [chemical binding]; other site 155864008165 ATP binding site [chemical binding]; other site 155864008166 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 155864008167 substrate binding site [chemical binding]; other site 155864008168 multimerization interface [polypeptide binding]; other site 155864008169 ATP binding site [chemical binding]; other site 155864008170 O-island #89; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864008171 O-island #89; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864008172 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 155864008173 putative metal binding site [ion binding]; other site 155864008174 putative homodimer interface [polypeptide binding]; other site 155864008175 putative homotetramer interface [polypeptide binding]; other site 155864008176 putative homodimer-homodimer interface [polypeptide binding]; other site 155864008177 putative allosteric switch controlling residues; other site 155864008178 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 155864008179 Predicted integral membrane protein [Function unknown]; Region: COG5455 155864008180 putative fimbrial-like adhesin protein StcD; Provisional; Region: PRK15252 155864008181 putative fimbrial biosynthesis regulatory protein; Provisional; Region: PRK15216 155864008182 fimbrial outer membrane usher protein; Provisional; Region: PRK15217 155864008183 PapC N-terminal domain; Region: PapC_N; pfam13954 155864008184 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 155864008185 PapC C-terminal domain; Region: PapC_C; pfam13953 155864008186 putative fimbrial assembly chaperone protein StcB; Provisional; Region: PRK15253 155864008187 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 155864008188 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 155864008189 Fimbrial protein; Region: Fimbrial; cl01416 155864008190 Protein of unknown function (DUF2574); Region: DUF2574; pfam10836 155864008191 antiporter inner membrane protein; Provisional; Region: PRK11670 155864008192 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 155864008193 Walker A motif; other site 155864008194 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 155864008195 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 155864008196 active site 155864008197 HIGH motif; other site 155864008198 KMSKS motif; other site 155864008199 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 155864008200 tRNA binding surface [nucleotide binding]; other site 155864008201 anticodon binding site; other site 155864008202 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 155864008203 dimer interface [polypeptide binding]; other site 155864008204 putative tRNA-binding site [nucleotide binding]; other site 155864008205 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 155864008206 O-island #90; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864008207 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 155864008208 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 155864008209 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 155864008210 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 155864008211 O-island #91; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864008212 O-island #91; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864008213 similar to hypothetical protein; No significant matches 155864008214 similar to hypothetical protein; No significant matches 155864008215 MoxR-like ATPases [General function prediction only]; Region: COG0714 155864008216 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 155864008217 Walker A motif; other site 155864008218 ATP binding site [chemical binding]; other site 155864008219 Walker B motif; other site 155864008220 arginine finger; other site 155864008221 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 155864008222 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 155864008223 metal ion-dependent adhesion site (MIDAS); other site 155864008224 O-island #92; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864008225 putative transposase OrfB; Reviewed; Region: PHA02517 155864008226 HTH-like domain; Region: HTH_21; pfam13276 155864008227 Integrase core domain; Region: rve; pfam00665 155864008228 Integrase core domain; Region: rve_3; pfam13683 155864008229 Transposase; Region: HTH_Tnp_1; cl17663 155864008230 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 155864008231 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 155864008232 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 155864008233 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 155864008234 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 155864008235 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 155864008236 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 155864008237 active site 155864008238 phosphorylation site [posttranslational modification] 155864008239 intermolecular recognition site; other site 155864008240 dimerization interface [polypeptide binding]; other site 155864008241 LytTr DNA-binding domain; Region: LytTR; pfam04397 155864008242 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 155864008243 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 155864008244 GAF domain; Region: GAF; pfam01590 155864008245 Histidine kinase; Region: His_kinase; pfam06580 155864008246 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 155864008247 ATP binding site [chemical binding]; other site 155864008248 Mg2+ binding site [ion binding]; other site 155864008249 G-X-G motif; other site 155864008250 O-island #93; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655; Cryptic prophage CP-933V; includes one copy of the 21 bp direct repeat that flanks the prophage; encodes Stx1A and Stx1B subunits of a Shiga-like toxin 155864008251 DinI-like family; Region: DinI; pfam06183 155864008252 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 155864008253 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 155864008254 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 155864008255 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 155864008256 Phage-related protein, tail component [Function unknown]; Region: COG4733 155864008257 Putative phage tail protein; Region: Phage-tail_3; pfam13550 155864008258 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 155864008259 Fibronectin type III protein; Region: DUF3672; pfam12421 155864008260 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 155864008261 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 155864008262 E-class dimer interface [polypeptide binding]; other site 155864008263 P-class dimer interface [polypeptide binding]; other site 155864008264 active site 155864008265 Cu2+ binding site [ion binding]; other site 155864008266 Zn2+ binding site [ion binding]; other site 155864008267 Phage-related protein, tail component [Function unknown]; Region: COG4723 155864008268 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 155864008269 MPN+ (JAMM) motif; other site 155864008270 Zinc-binding site [ion binding]; other site 155864008271 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 155864008272 NlpC/P60 family; Region: NLPC_P60; cl17555 155864008273 Phage-related protein [Function unknown]; Region: gp18; COG4672 155864008274 O-island #93; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655; Cryptic prophage CP-933V; includes one copy of the 21 bp direct repeat that flanks the prophage; encodes Stx1A and Stx1B subunits of a Shiga-like toxin 155864008275 Phage-related minor tail protein [Function unknown]; Region: COG5281 155864008276 Phage-related minor tail protein [Function unknown]; Region: COG5281 155864008277 tape measure domain; Region: tape_meas_nterm; TIGR02675 155864008278 Tail length tape measure protein; Region: Phage_HK97_TLTM; pfam06120 155864008279 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 155864008280 Protein of unknown function (DUF4035); Region: DUF4035; pfam13227 155864008281 Phage tail assembly chaperone; Region: Phage_TAC; pfam06222 155864008282 Phage major tail protein 2; Region: Phage_tail_2; cl11463 155864008283 Immunoglobulin I-set domain; Region: I-set; pfam07679 155864008284 Immunoglobulin domain; Region: Ig_2; pfam13895 155864008285 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 155864008286 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 155864008287 Bacteriophage head-tail adaptor [General function prediction only]; Region: COG5614 155864008288 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 155864008289 oligomerization interface [polypeptide binding]; other site 155864008290 Phage-related protein [Function unknown]; Region: COG4695 155864008291 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 155864008292 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 155864008293 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 155864008294 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 155864008295 Phage capsid family; Region: Phage_capsid; pfam05065 155864008296 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 155864008297 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 155864008298 O-island #93; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655; Cryptic prophage CP-933V; includes one copy of the 21 bp direct repeat that flanks the prophage; encodes Stx1A and Stx1B subunits of a Shiga-like toxin 155864008299 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 155864008300 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 155864008301 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 155864008302 ORF11CD3 domain; Region: ORF11CD3; pfam10549 155864008303 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 155864008304 catalytic residues [active] 155864008305 Lysis protein S; Region: Lysis_S; pfam04971 155864008306 Protein of unknown function (DUF826); Region: DUF826; pfam05696 155864008307 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 155864008308 Domain of unknown function (DUF303); Region: DUF303; pfam03629 155864008309 Shiga-like toxin beta subunit; Region: SLT_beta; pfam02258 155864008310 Ribosome inactivating protein; Region: RIP; pfam00161 155864008311 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 155864008312 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 155864008313 O-island #93; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655; Cryptic prophage CP-933V; includes one copy of the 21 bp direct repeat that flanks the prophage; encodes Stx1A and Stx1B subunits of a Shiga-like toxin 155864008314 phage N-6-adenine-methyltransferase; Region: phage_N6A_met; TIGR01712 155864008315 NinB protein; Region: NinB; pfam05772 155864008316 Restriction alleviation protein Lar; Region: Lar_restr_allev; cl08047 155864008317 Replication protein P; Region: Phage_lambda_P; pfam06992 155864008318 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 155864008319 Bacteriophage CII protein; Region: Phage_CII; pfam05269 155864008320 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 155864008321 non-specific DNA binding site [nucleotide binding]; other site 155864008322 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 155864008323 salt bridge; other site 155864008324 sequence-specific DNA binding site [nucleotide binding]; other site 155864008325 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 155864008326 Catalytic site [active] 155864008327 Superinfection exclusion protein B; Region: SieB; pfam14163 155864008328 Protein of unknown function (DUF2528); Region: DUF2528; pfam10800 155864008329 Bacteriophage lambda Kil protein; Region: Lambda_Kil; pfam06301 155864008330 Host-nuclease inhibitor protein Gam; Region: Gam; pfam06064 155864008331 phage recombination protein Bet; Region: bet_lambda; TIGR01913 155864008332 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 155864008333 O-island #93; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655; Cryptic prophage CP-933V; includes one copy of the 21 bp direct repeat that flanks the prophage; encodes Stx1A and Stx1B subunits of a Shiga-like toxin 155864008334 Protein of unknown function (DUF1382); Region: DUF1382; pfam07131 155864008335 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 155864008336 Protein of unknown function (DUF551); Region: DUF551; pfam04448 155864008337 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 155864008338 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 155864008339 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 155864008340 Int/Topo IB signature motif; other site 155864008341 transcriptional regulator MirA; Provisional; Region: PRK15043 155864008342 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 155864008343 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 155864008344 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 155864008345 dimer interface [polypeptide binding]; other site 155864008346 conserved gate region; other site 155864008347 putative PBP binding loops; other site 155864008348 ABC-ATPase subunit interface; other site 155864008349 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 155864008350 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 155864008351 Walker A/P-loop; other site 155864008352 ATP binding site [chemical binding]; other site 155864008353 Q-loop/lid; other site 155864008354 ABC transporter signature motif; other site 155864008355 Walker B; other site 155864008356 D-loop; other site 155864008357 H-loop/switch region; other site 155864008358 CBS domain; Region: CBS; pfam00571 155864008359 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 155864008360 dimer interface [polypeptide binding]; other site 155864008361 conserved gate region; other site 155864008362 ABC-ATPase subunit interface; other site 155864008363 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 155864008364 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 155864008365 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 155864008366 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 155864008367 D-lactate dehydrogenase; Provisional; Region: PRK11183 155864008368 FAD binding domain; Region: FAD_binding_4; pfam01565 155864008369 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 155864008370 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 155864008371 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 155864008372 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 155864008373 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 155864008374 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 155864008375 oxidoreductase; Provisional; Region: PRK12743 155864008376 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 155864008377 NAD(P) binding site [chemical binding]; other site 155864008378 active site 155864008379 multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459 155864008380 O-island #94; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864008381 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 155864008382 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 155864008383 FMN binding site [chemical binding]; other site 155864008384 active site 155864008385 catalytic residues [active] 155864008386 substrate binding site [chemical binding]; other site 155864008387 O-island #95; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864008388 O-island #95; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864008389 salicylate hydroxylase; Provisional; Region: PRK08163 155864008390 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 155864008391 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 155864008392 maleylacetoacetate isomerase; Region: maiA; TIGR01262 155864008393 C-terminal domain interface [polypeptide binding]; other site 155864008394 GSH binding site (G-site) [chemical binding]; other site 155864008395 putative dimer interface [polypeptide binding]; other site 155864008396 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 155864008397 dimer interface [polypeptide binding]; other site 155864008398 N-terminal domain interface [polypeptide binding]; other site 155864008399 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 155864008400 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 155864008401 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 155864008402 gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272 155864008403 Cupin domain; Region: Cupin_2; pfam07883 155864008404 Cupin domain; Region: Cupin_2; cl17218 155864008405 benzoate transport; Region: 2A0115; TIGR00895 155864008406 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864008407 putative substrate translocation pore; other site 155864008408 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 155864008409 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 155864008410 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 155864008411 dimerization interface [polypeptide binding]; other site 155864008412 hypothetical protein; Provisional; Region: PRK01821 155864008413 hypothetical protein; Provisional; Region: PRK10711 155864008414 cytidine deaminase; Provisional; Region: PRK09027 155864008415 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 155864008416 active site 155864008417 catalytic motif [active] 155864008418 Zn binding site [ion binding]; other site 155864008419 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 155864008420 active site 155864008421 catalytic motif [active] 155864008422 Zn binding site [ion binding]; other site 155864008423 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 155864008424 putative active site [active] 155864008425 Protein of unknown function (DUF2542); Region: DUF2542; pfam10808 155864008426 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 155864008427 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 155864008428 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 155864008429 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 155864008430 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 155864008431 homodimer interface [polypeptide binding]; other site 155864008432 active site 155864008433 FMN binding site [chemical binding]; other site 155864008434 substrate binding site [chemical binding]; other site 155864008435 4Fe-4S binding domain; Region: Fer4; pfam00037 155864008436 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 155864008437 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 155864008438 TM-ABC transporter signature motif; other site 155864008439 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 155864008440 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 155864008441 Walker A/P-loop; other site 155864008442 ATP binding site [chemical binding]; other site 155864008443 Q-loop/lid; other site 155864008444 ABC transporter signature motif; other site 155864008445 Walker B; other site 155864008446 D-loop; other site 155864008447 H-loop/switch region; other site 155864008448 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 155864008449 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 155864008450 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 155864008451 ligand binding site [chemical binding]; other site 155864008452 calcium binding site [ion binding]; other site 155864008453 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 155864008454 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 155864008455 DNA binding site [nucleotide binding] 155864008456 domain linker motif; other site 155864008457 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 155864008458 dimerization interface (closed form) [polypeptide binding]; other site 155864008459 ligand binding site [chemical binding]; other site 155864008460 Predicted membrane protein [Function unknown]; Region: COG2311 155864008461 hypothetical protein; Provisional; Region: PRK10835 155864008462 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 155864008463 homodecamer interface [polypeptide binding]; other site 155864008464 GTP cyclohydrolase I; Provisional; Region: PLN03044 155864008465 active site 155864008466 putative catalytic site residues [active] 155864008467 zinc binding site [ion binding]; other site 155864008468 GTP-CH-I/GFRP interaction surface; other site 155864008469 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 155864008470 S-formylglutathione hydrolase; Region: PLN02442 155864008471 catecholate siderophore receptor CirA; Provisional; Region: PRK10064 155864008472 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 155864008473 N-terminal plug; other site 155864008474 ligand-binding site [chemical binding]; other site 155864008475 lysine transporter; Provisional; Region: PRK10836 155864008476 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 155864008477 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 155864008478 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 155864008479 putative dimerization interface [polypeptide binding]; other site 155864008480 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 155864008481 endonuclease IV; Provisional; Region: PRK01060 155864008482 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 155864008483 AP (apurinic/apyrimidinic) site pocket; other site 155864008484 DNA interaction; other site 155864008485 Metal-binding active site; metal-binding site 155864008486 putative kinase; Provisional; Region: PRK09954 155864008487 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 155864008488 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 155864008489 substrate binding site [chemical binding]; other site 155864008490 ATP binding site [chemical binding]; other site 155864008491 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 155864008492 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 155864008493 Nucleoside recognition; Region: Gate; pfam07670 155864008494 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 155864008495 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 155864008496 active site 155864008497 tetramer interface [polypeptide binding]; other site 155864008498 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 155864008499 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 155864008500 ligand binding site [chemical binding]; other site 155864008501 flexible hinge region; other site 155864008502 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 155864008503 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 155864008504 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 155864008505 Nucleoside recognition; Region: Gate; pfam07670 155864008506 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 155864008507 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 155864008508 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 155864008509 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 155864008510 substrate binding site [chemical binding]; other site 155864008511 ATP binding site [chemical binding]; other site 155864008512 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 155864008513 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 155864008514 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 155864008515 active site 155864008516 P-loop; other site 155864008517 phosphorylation site [posttranslational modification] 155864008518 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 155864008519 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 155864008520 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 155864008521 putative substrate binding site [chemical binding]; other site 155864008522 putative ATP binding site [chemical binding]; other site 155864008523 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 155864008524 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 155864008525 active site 155864008526 phosphorylation site [posttranslational modification] 155864008527 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 155864008528 dimerization domain swap beta strand [polypeptide binding]; other site 155864008529 regulatory protein interface [polypeptide binding]; other site 155864008530 active site 155864008531 regulatory phosphorylation site [posttranslational modification]; other site 155864008532 sugar efflux transporter B; Provisional; Region: PRK15011 155864008533 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864008534 putative substrate translocation pore; other site 155864008535 elongation factor P; Provisional; Region: PRK04542 155864008536 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 155864008537 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 155864008538 RNA binding site [nucleotide binding]; other site 155864008539 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 155864008540 RNA binding site [nucleotide binding]; other site 155864008541 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 155864008542 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 155864008543 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 155864008544 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 155864008545 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 155864008546 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 155864008547 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 155864008548 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 155864008549 active site 155864008550 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 155864008551 NlpC/P60 family; Region: NLPC_P60; pfam00877 155864008552 phage resistance protein; Provisional; Region: PRK10551 155864008553 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 155864008554 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 155864008555 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 155864008556 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 155864008557 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 155864008558 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 155864008559 dimer interface [polypeptide binding]; other site 155864008560 conserved gate region; other site 155864008561 putative PBP binding loops; other site 155864008562 ABC-ATPase subunit interface; other site 155864008563 microcin C ABC transporter permease; Provisional; Region: PRK15021 155864008564 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 155864008565 dimer interface [polypeptide binding]; other site 155864008566 conserved gate region; other site 155864008567 ABC-ATPase subunit interface; other site 155864008568 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 155864008569 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 155864008570 Walker A/P-loop; other site 155864008571 ATP binding site [chemical binding]; other site 155864008572 Q-loop/lid; other site 155864008573 ABC transporter signature motif; other site 155864008574 Walker B; other site 155864008575 D-loop; other site 155864008576 H-loop/switch region; other site 155864008577 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 155864008578 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 155864008579 Walker A/P-loop; other site 155864008580 ATP binding site [chemical binding]; other site 155864008581 Q-loop/lid; other site 155864008582 ABC transporter signature motif; other site 155864008583 Walker B; other site 155864008584 D-loop; other site 155864008585 H-loop/switch region; other site 155864008586 hypothetical protein; Provisional; Region: PRK11835 155864008587 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864008588 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 155864008589 putative substrate translocation pore; other site 155864008590 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 155864008591 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 155864008592 RNA binding surface [nucleotide binding]; other site 155864008593 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 155864008594 active site 155864008595 uracil binding [chemical binding]; other site 155864008596 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 155864008597 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 155864008598 ATP binding site [chemical binding]; other site 155864008599 putative Mg++ binding site [ion binding]; other site 155864008600 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 155864008601 nucleotide binding region [chemical binding]; other site 155864008602 ATP-binding site [chemical binding]; other site 155864008603 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 155864008604 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 155864008605 5S rRNA interface [nucleotide binding]; other site 155864008606 CTC domain interface [polypeptide binding]; other site 155864008607 L16 interface [polypeptide binding]; other site 155864008608 Nucleoid-associated protein [General function prediction only]; Region: COG3081 155864008609 nucleoid-associated protein NdpA; Validated; Region: PRK00378 155864008610 hypothetical protein; Provisional; Region: PRK13689 155864008611 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 155864008612 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 155864008613 Sulfatase; Region: Sulfatase; pfam00884 155864008614 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 155864008615 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 155864008616 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 155864008617 Autotransporter beta-domain; Region: Autotransporter; pfam03797 155864008618 transcriptional regulator NarP; Provisional; Region: PRK10403 155864008619 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 155864008620 active site 155864008621 phosphorylation site [posttranslational modification] 155864008622 intermolecular recognition site; other site 155864008623 dimerization interface [polypeptide binding]; other site 155864008624 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 155864008625 DNA binding residues [nucleotide binding] 155864008626 dimerization interface [polypeptide binding]; other site 155864008627 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 155864008628 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 155864008629 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 155864008630 binding surface 155864008631 TPR motif; other site 155864008632 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 155864008633 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 155864008634 catalytic residues [active] 155864008635 central insert; other site 155864008636 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 155864008637 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 155864008638 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 155864008639 heme exporter protein CcmC; Region: ccmC; TIGR01191 155864008640 heme exporter protein CcmB; Region: ccmB; TIGR01190 155864008641 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 155864008642 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 155864008643 Walker A/P-loop; other site 155864008644 ATP binding site [chemical binding]; other site 155864008645 Q-loop/lid; other site 155864008646 ABC transporter signature motif; other site 155864008647 Walker B; other site 155864008648 D-loop; other site 155864008649 H-loop/switch region; other site 155864008650 cytochrome c-type protein NapC; Provisional; Region: PRK10617 155864008651 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 155864008652 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 155864008653 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 155864008654 4Fe-4S binding domain; Region: Fer4_5; pfam12801 155864008655 4Fe-4S binding domain; Region: Fer4; cl02805 155864008656 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 155864008657 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 155864008658 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 155864008659 [4Fe-4S] binding site [ion binding]; other site 155864008660 molybdopterin cofactor binding site; other site 155864008661 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 155864008662 molybdopterin cofactor binding site; other site 155864008663 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 155864008664 ferredoxin-type protein; Provisional; Region: PRK10194 155864008665 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 155864008666 secondary substrate binding site; other site 155864008667 primary substrate binding site; other site 155864008668 inhibition loop; other site 155864008669 dimerization interface [polypeptide binding]; other site 155864008670 malate:quinone oxidoreductase; Validated; Region: PRK05257 155864008671 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 155864008672 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 155864008673 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 155864008674 Walker A/P-loop; other site 155864008675 ATP binding site [chemical binding]; other site 155864008676 Q-loop/lid; other site 155864008677 ABC transporter signature motif; other site 155864008678 Walker B; other site 155864008679 D-loop; other site 155864008680 H-loop/switch region; other site 155864008681 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 155864008682 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 155864008683 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 155864008684 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 155864008685 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 155864008686 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 155864008687 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 155864008688 DNA binding site [nucleotide binding] 155864008689 active site 155864008690 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 155864008691 ApbE family; Region: ApbE; pfam02424 155864008692 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 155864008693 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 155864008694 trimer interface [polypeptide binding]; other site 155864008695 eyelet of channel; other site 155864008696 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 155864008697 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 155864008698 ATP binding site [chemical binding]; other site 155864008699 G-X-G motif; other site 155864008700 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 155864008701 putative binding surface; other site 155864008702 active site 155864008703 transcriptional regulator RcsB; Provisional; Region: PRK10840 155864008704 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 155864008705 active site 155864008706 phosphorylation site [posttranslational modification] 155864008707 intermolecular recognition site; other site 155864008708 dimerization interface [polypeptide binding]; other site 155864008709 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 155864008710 DNA binding residues [nucleotide binding] 155864008711 dimerization interface [polypeptide binding]; other site 155864008712 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 155864008713 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 155864008714 dimer interface [polypeptide binding]; other site 155864008715 phosphorylation site [posttranslational modification] 155864008716 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 155864008717 ATP binding site [chemical binding]; other site 155864008718 Mg2+ binding site [ion binding]; other site 155864008719 G-X-G motif; other site 155864008720 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 155864008721 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 155864008722 active site 155864008723 phosphorylation site [posttranslational modification] 155864008724 intermolecular recognition site; other site 155864008725 dimerization interface [polypeptide binding]; other site 155864008726 O-island #96; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864008727 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 155864008728 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 155864008729 Predicted secreted protein [Function unknown]; Region: COG5445 155864008730 Stage II sporulation protein; Region: SpoIID; pfam08486 155864008731 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 155864008732 Predicted secreted protein [Function unknown]; Region: COG5445 155864008733 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 155864008734 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 155864008735 MG2 domain; Region: A2M_N; pfam01835 155864008736 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 155864008737 Alpha-2-macroglobulin family; Region: A2M; pfam00207 155864008738 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 155864008739 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3234 155864008740 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4685 155864008741 DNA gyrase subunit A; Validated; Region: PRK05560 155864008742 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 155864008743 CAP-like domain; other site 155864008744 active site 155864008745 primary dimer interface [polypeptide binding]; other site 155864008746 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 155864008747 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 155864008748 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 155864008749 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 155864008750 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 155864008751 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 155864008752 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 155864008753 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 155864008754 S-adenosylmethionine binding site [chemical binding]; other site 155864008755 adhesin; Provisional; Region: PRK09752 155864008756 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 155864008757 Autotransporter beta-domain; Region: Autotransporter; pfam03797 155864008758 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 155864008759 ATP cone domain; Region: ATP-cone; pfam03477 155864008760 Class I ribonucleotide reductase; Region: RNR_I; cd01679 155864008761 active site 155864008762 dimer interface [polypeptide binding]; other site 155864008763 catalytic residues [active] 155864008764 effector binding site; other site 155864008765 R2 peptide binding site; other site 155864008766 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 155864008767 dimer interface [polypeptide binding]; other site 155864008768 putative radical transfer pathway; other site 155864008769 diiron center [ion binding]; other site 155864008770 tyrosyl radical; other site 155864008771 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 155864008772 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 155864008773 catalytic loop [active] 155864008774 iron binding site [ion binding]; other site 155864008775 hypothetical protein; Provisional; Region: PRK09902 155864008776 Major Facilitator Superfamily; Region: MFS_1; pfam07690 155864008777 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864008778 putative substrate translocation pore; other site 155864008779 O-island #97; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864008780 Transcriptional regulator [Transcription]; Region: LysR; COG0583 155864008781 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 155864008782 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 155864008783 dimerization interface [polypeptide binding]; other site 155864008784 O-island #98; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864008785 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 155864008786 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 155864008787 active site 155864008788 catalytic site [active] 155864008789 metal binding site [ion binding]; metal-binding site 155864008790 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 155864008791 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864008792 putative substrate translocation pore; other site 155864008793 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 155864008794 hydroxyglutarate oxidase; Provisional; Region: PRK11728 155864008795 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 155864008796 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 155864008797 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 155864008798 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 155864008799 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 155864008800 Cysteine-rich domain; Region: CCG; pfam02754 155864008801 Cysteine-rich domain; Region: CCG; pfam02754 155864008802 hypothetical protein; Provisional; Region: PRK09956 155864008803 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 155864008804 2-keto-3-deoxy-L-rhamnonate aldolase; Provisional; Region: PRK10128 155864008805 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 155864008806 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864008807 putative substrate translocation pore; other site 155864008808 L-rhamnonate dehydratase; Provisional; Region: PRK15440 155864008809 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 155864008810 putative active site pocket [active] 155864008811 putative metal binding site [ion binding]; other site 155864008812 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 155864008813 Transcriptional regulator [Transcription]; Region: IclR; COG1414 155864008814 Bacterial transcriptional regulator; Region: IclR; pfam01614 155864008815 hypothetical protein; Provisional; Region: PRK03673 155864008816 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 155864008817 putative MPT binding site; other site 155864008818 Competence-damaged protein; Region: CinA; cl00666 155864008819 YfaZ precursor; Region: YfaZ; pfam07437 155864008820 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 155864008821 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 155864008822 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 155864008823 catalytic core [active] 155864008824 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 155864008825 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 155864008826 inhibitor-cofactor binding pocket; inhibition site 155864008827 pyridoxal 5'-phosphate binding site [chemical binding]; other site 155864008828 catalytic residue [active] 155864008829 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 155864008830 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 155864008831 Ligand binding site; other site 155864008832 Putative Catalytic site; other site 155864008833 DXD motif; other site 155864008834 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 155864008835 ArnA, N-terminal formyltransferase domain; Region: FMT_core_ArnA_N; cd08644 155864008836 substrate binding site [chemical binding]; other site 155864008837 cosubstrate binding site; other site 155864008838 catalytic site [active] 155864008839 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 155864008840 active site 155864008841 hexamer interface [polypeptide binding]; other site 155864008842 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 155864008843 NAD binding site [chemical binding]; other site 155864008844 substrate binding site [chemical binding]; other site 155864008845 active site 155864008846 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 155864008847 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 155864008848 putative active site [active] 155864008849 putative catalytic site [active] 155864008850 putative Zn binding site [ion binding]; other site 155864008851 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 155864008852 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 155864008853 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 155864008854 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 155864008855 signal transduction protein PmrD; Provisional; Region: PRK15450 155864008856 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 155864008857 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 155864008858 acyl-activating enzyme (AAE) consensus motif; other site 155864008859 putative AMP binding site [chemical binding]; other site 155864008860 putative active site [active] 155864008861 putative CoA binding site [chemical binding]; other site 155864008862 O-succinylbenzoate synthase; Provisional; Region: PRK05105 155864008863 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 155864008864 active site 155864008865 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 155864008866 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 155864008867 substrate binding site [chemical binding]; other site 155864008868 oxyanion hole (OAH) forming residues; other site 155864008869 trimer interface [polypeptide binding]; other site 155864008870 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 155864008871 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 155864008872 nucleophilic elbow; other site 155864008873 catalytic triad; other site 155864008874 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 155864008875 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 155864008876 dimer interface [polypeptide binding]; other site 155864008877 tetramer interface [polypeptide binding]; other site 155864008878 PYR/PP interface [polypeptide binding]; other site 155864008879 TPP binding site [chemical binding]; other site 155864008880 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 155864008881 TPP-binding site; other site 155864008882 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 155864008883 isochorismate synthases; Region: isochor_syn; TIGR00543 155864008884 hypothetical protein; Provisional; Region: PRK10404 155864008885 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 155864008886 Coenzyme A binding pocket [chemical binding]; other site 155864008887 ribonuclease BN; Region: true_RNase_BN; TIGR02649 155864008888 deubiquitinase; Provisional; Region: PRK11836 155864008889 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 155864008890 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 155864008891 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 155864008892 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 155864008893 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 155864008894 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 155864008895 O-island #99; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864008896 O-island #99; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864008897 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 155864008898 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 155864008899 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 155864008900 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 155864008901 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 155864008902 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 155864008903 4Fe-4S binding domain; Region: Fer4; pfam00037 155864008904 4Fe-4S binding domain; Region: Fer4; pfam00037 155864008905 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 155864008906 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 155864008907 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 155864008908 catalytic loop [active] 155864008909 iron binding site [ion binding]; other site 155864008910 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 155864008911 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 155864008912 [4Fe-4S] binding site [ion binding]; other site 155864008913 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 155864008914 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 155864008915 SLBB domain; Region: SLBB; pfam10531 155864008916 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 155864008917 NADH dehydrogenase subunit E; Validated; Region: PRK07539 155864008918 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 155864008919 putative dimer interface [polypeptide binding]; other site 155864008920 [2Fe-2S] cluster binding site [ion binding]; other site 155864008921 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 155864008922 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 155864008923 NADH dehydrogenase subunit D; Validated; Region: PRK06075 155864008924 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 155864008925 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 155864008926 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 155864008927 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 155864008928 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 155864008929 putative dimerization interface [polypeptide binding]; other site 155864008930 aminotransferase AlaT; Validated; Region: PRK09265 155864008931 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 155864008932 pyridoxal 5'-phosphate binding site [chemical binding]; other site 155864008933 homodimer interface [polypeptide binding]; other site 155864008934 catalytic residue [active] 155864008935 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 155864008936 Zn2+ binding site [ion binding]; other site 155864008937 Mg2+ binding site [ion binding]; other site 155864008938 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 155864008939 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 155864008940 TrkA-C domain; Region: TrkA_C; pfam02080 155864008941 TrkA-C domain; Region: TrkA_C; pfam02080 155864008942 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 155864008943 putative phosphatase; Provisional; Region: PRK11587 155864008944 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 155864008945 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 155864008946 motif II; other site 155864008947 hypothetical protein; Validated; Region: PRK05445 155864008948 hypothetical protein; Provisional; Region: PRK01816 155864008949 propionate/acetate kinase; Provisional; Region: PRK12379 155864008950 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 155864008951 phosphate acetyltransferase; Reviewed; Region: PRK05632 155864008952 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 155864008953 DRTGG domain; Region: DRTGG; pfam07085 155864008954 phosphate acetyltransferase; Region: pta; TIGR00651 155864008955 hypothetical protein; Provisional; Region: PRK11588 155864008956 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 155864008957 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 155864008958 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 155864008959 nudix motif; other site 155864008960 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 155864008961 active site 155864008962 metal binding site [ion binding]; metal-binding site 155864008963 homotetramer interface [polypeptide binding]; other site 155864008964 glutathione S-transferase; Provisional; Region: PRK15113 155864008965 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 155864008966 C-terminal domain interface [polypeptide binding]; other site 155864008967 GSH binding site (G-site) [chemical binding]; other site 155864008968 dimer interface [polypeptide binding]; other site 155864008969 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 155864008970 N-terminal domain interface [polypeptide binding]; other site 155864008971 putative dimer interface [polypeptide binding]; other site 155864008972 putative substrate binding pocket (H-site) [chemical binding]; other site 155864008973 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 155864008974 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 155864008975 C-terminal domain interface [polypeptide binding]; other site 155864008976 GSH binding site (G-site) [chemical binding]; other site 155864008977 dimer interface [polypeptide binding]; other site 155864008978 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 155864008979 N-terminal domain interface [polypeptide binding]; other site 155864008980 putative dimer interface [polypeptide binding]; other site 155864008981 active site 155864008982 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 155864008983 homooctamer interface [polypeptide binding]; other site 155864008984 active site 155864008985 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 155864008986 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 155864008987 putative NAD(P) binding site [chemical binding]; other site 155864008988 putative active site [active] 155864008989 putative transposase; Provisional; Region: PRK09857 155864008990 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 155864008991 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 155864008992 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 155864008993 Walker A/P-loop; other site 155864008994 ATP binding site [chemical binding]; other site 155864008995 Q-loop/lid; other site 155864008996 ABC transporter signature motif; other site 155864008997 Walker B; other site 155864008998 D-loop; other site 155864008999 H-loop/switch region; other site 155864009000 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 155864009001 dimer interface [polypeptide binding]; other site 155864009002 conserved gate region; other site 155864009003 putative PBP binding loops; other site 155864009004 ABC-ATPase subunit interface; other site 155864009005 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 155864009006 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 155864009007 dimer interface [polypeptide binding]; other site 155864009008 conserved gate region; other site 155864009009 putative PBP binding loops; other site 155864009010 ABC-ATPase subunit interface; other site 155864009011 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 155864009012 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 155864009013 substrate binding pocket [chemical binding]; other site 155864009014 membrane-bound complex binding site; other site 155864009015 hinge residues; other site 155864009016 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 155864009017 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 155864009018 substrate binding pocket [chemical binding]; other site 155864009019 membrane-bound complex binding site; other site 155864009020 hinge residues; other site 155864009021 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 155864009022 Flavoprotein; Region: Flavoprotein; pfam02441 155864009023 amidophosphoribosyltransferase; Provisional; Region: PRK09246 155864009024 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 155864009025 active site 155864009026 tetramer interface [polypeptide binding]; other site 155864009027 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 155864009028 active site 155864009029 colicin V production protein; Provisional; Region: PRK10845 155864009030 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 155864009031 O-island #100; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864009032 cell division protein DedD; Provisional; Region: PRK11633 155864009033 Sporulation related domain; Region: SPOR; pfam05036 155864009034 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 155864009035 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 155864009036 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 155864009037 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 155864009038 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 155864009039 hypothetical protein; Provisional; Region: PRK10847 155864009040 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 155864009041 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 155864009042 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 155864009043 dimerization interface 3.5A [polypeptide binding]; other site 155864009044 active site 155864009045 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 155864009046 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 155864009047 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 155864009048 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 155864009049 ligand binding site [chemical binding]; other site 155864009050 NAD binding site [chemical binding]; other site 155864009051 catalytic site [active] 155864009052 homodimer interface [polypeptide binding]; other site 155864009053 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 155864009054 putative transporter; Provisional; Region: PRK12382 155864009055 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864009056 putative substrate translocation pore; other site 155864009057 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 155864009058 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 155864009059 dimer interface [polypeptide binding]; other site 155864009060 active site 155864009061 Uncharacterized conserved protein [Function unknown]; Region: COG4121 155864009062 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 155864009063 YfcL protein; Region: YfcL; pfam08891 155864009064 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 155864009065 hypothetical protein; Provisional; Region: PRK10621 155864009066 Predicted permeases [General function prediction only]; Region: COG0730 155864009067 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 155864009068 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 155864009069 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 155864009070 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 155864009071 Tetramer interface [polypeptide binding]; other site 155864009072 active site 155864009073 FMN-binding site [chemical binding]; other site 155864009074 HemK family putative methylases; Region: hemK_fam; TIGR00536 155864009075 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 155864009076 S-adenosylmethionine binding site [chemical binding]; other site 155864009077 hypothetical protein; Provisional; Region: PRK04946 155864009078 Smr domain; Region: Smr; pfam01713 155864009079 Protein of unknown function (DUF2544); Region: DUF2544; pfam11245 155864009080 Fimbrial protein; Region: Fimbrial; cl01416 155864009081 Fimbrial protein; Region: Fimbrial; cl01416 155864009082 Fimbrial protein; Region: Fimbrial; cl01416 155864009083 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 155864009084 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 155864009085 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 155864009086 PapC N-terminal domain; Region: PapC_N; pfam13954 155864009087 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 155864009088 PapC C-terminal domain; Region: PapC_C; pfam13953 155864009089 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 155864009090 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 155864009091 catalytic core [active] 155864009092 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 155864009093 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 155864009094 substrate binding site [chemical binding]; other site 155864009095 oxyanion hole (OAH) forming residues; other site 155864009096 trimer interface [polypeptide binding]; other site 155864009097 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 155864009098 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 155864009099 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 155864009100 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 155864009101 dimer interface [polypeptide binding]; other site 155864009102 active site 155864009103 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 155864009104 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 155864009105 O-island #101; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864009106 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 155864009107 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 155864009108 integrase; Provisional; Region: PRK09692 155864009109 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 155864009110 active site 155864009111 Int/Topo IB signature motif; other site 155864009112 O-island #102; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864009113 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 155864009114 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 155864009115 Protein of unknown function (DUF2824); Region: DUF2824; cl10279 155864009116 O-island #102; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864009117 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 155864009118 Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient...; Region: SR_Res_par; cd03767 155864009119 catalytic residues [active] 155864009120 catalytic nucleophile [active] 155864009121 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 155864009122 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864009123 putative substrate translocation pore; other site 155864009124 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 155864009125 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 155864009126 putative ATP binding site [chemical binding]; other site 155864009127 putative substrate binding site [chemical binding]; other site 155864009128 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 155864009129 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 155864009130 substrate binding [chemical binding]; other site 155864009131 active site 155864009132 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 155864009133 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 155864009134 DNA binding site [nucleotide binding] 155864009135 domain linker motif; other site 155864009136 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 155864009137 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 155864009138 putative dimerization interface [polypeptide binding]; other site 155864009139 putative ligand binding site [chemical binding]; other site 155864009140 fructuronate transporter; Provisional; Region: PRK10034; cl15264 155864009141 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 155864009142 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 155864009143 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 155864009144 catalytic residue [active] 155864009145 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 155864009146 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864009147 putative substrate translocation pore; other site 155864009148 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864009149 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 155864009150 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 155864009151 HlyD family secretion protein; Region: HlyD_3; pfam13437 155864009152 DNA-binding transcriptional activator EvgA; Provisional; Region: PRK09958 155864009153 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 155864009154 active site 155864009155 phosphorylation site [posttranslational modification] 155864009156 intermolecular recognition site; other site 155864009157 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 155864009158 DNA binding residues [nucleotide binding] 155864009159 dimerization interface [polypeptide binding]; other site 155864009160 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 155864009161 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 155864009162 substrate binding pocket [chemical binding]; other site 155864009163 membrane-bound complex binding site; other site 155864009164 hinge residues; other site 155864009165 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 155864009166 substrate binding pocket [chemical binding]; other site 155864009167 membrane-bound complex binding site; other site 155864009168 hinge residues; other site 155864009169 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 155864009170 dimer interface [polypeptide binding]; other site 155864009171 phosphorylation site [posttranslational modification] 155864009172 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 155864009173 ATP binding site [chemical binding]; other site 155864009174 Mg2+ binding site [ion binding]; other site 155864009175 G-X-G motif; other site 155864009176 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 155864009177 active site 155864009178 phosphorylation site [posttranslational modification] 155864009179 intermolecular recognition site; other site 155864009180 dimerization interface [polypeptide binding]; other site 155864009181 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 155864009182 putative binding surface; other site 155864009183 active site 155864009184 putative CoA-transferase; Provisional; Region: PRK11430 155864009185 CoA-transferase family III; Region: CoA_transf_3; pfam02515 155864009186 putative transporter YfdV; Provisional; Region: PRK09903 155864009187 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 155864009188 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 155864009189 PYR/PP interface [polypeptide binding]; other site 155864009190 dimer interface [polypeptide binding]; other site 155864009191 TPP binding site [chemical binding]; other site 155864009192 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 155864009193 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 155864009194 TPP-binding site; other site 155864009195 dimer interface [polypeptide binding]; other site 155864009196 formyl-coenzyme A transferase; Provisional; Region: PRK05398 155864009197 CoA-transferase family III; Region: CoA_transf_3; pfam02515 155864009198 hypothetical protein; Provisional; Region: PRK10316 155864009199 YfdX protein; Region: YfdX; pfam10938 155864009200 Protein of unknown function (DUF2545); Region: DUF2545; pfam10810 155864009201 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 155864009202 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 155864009203 putative acyl-acceptor binding pocket; other site 155864009204 aminotransferase; Validated; Region: PRK08175 155864009205 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 155864009206 pyridoxal 5'-phosphate binding site [chemical binding]; other site 155864009207 homodimer interface [polypeptide binding]; other site 155864009208 catalytic residue [active] 155864009209 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 155864009210 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 155864009211 GAF domain; Region: GAF; pfam01590 155864009212 Histidine kinase; Region: His_kinase; pfam06580 155864009213 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 155864009214 ATP binding site [chemical binding]; other site 155864009215 Mg2+ binding site [ion binding]; other site 155864009216 G-X-G motif; other site 155864009217 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 155864009218 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 155864009219 active site 155864009220 phosphorylation site [posttranslational modification] 155864009221 intermolecular recognition site; other site 155864009222 dimerization interface [polypeptide binding]; other site 155864009223 LytTr DNA-binding domain; Region: LytTR; pfam04397 155864009224 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 155864009225 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 155864009226 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 155864009227 dimerization domain swap beta strand [polypeptide binding]; other site 155864009228 regulatory protein interface [polypeptide binding]; other site 155864009229 active site 155864009230 regulatory phosphorylation site [posttranslational modification]; other site 155864009231 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 155864009232 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 155864009233 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 155864009234 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 155864009235 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 155864009236 active site 155864009237 phosphorylation site [posttranslational modification] 155864009238 exoaminopeptidase; Provisional; Region: PRK09961 155864009239 M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638 155864009240 oligomer interface [polypeptide binding]; other site 155864009241 active site 155864009242 metal binding site [ion binding]; metal-binding site 155864009243 aminopeptidase; Provisional; Region: PRK09795 155864009244 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 155864009245 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 155864009246 active site 155864009247 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 155864009248 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 155864009249 active site 155864009250 P-loop; other site 155864009251 phosphorylation site [posttranslational modification] 155864009252 glucokinase, proteobacterial type; Region: glk; TIGR00749 155864009253 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 155864009254 nucleotide binding site [chemical binding]; other site 155864009255 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 155864009256 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 155864009257 Cl- selectivity filter; other site 155864009258 Cl- binding residues [ion binding]; other site 155864009259 pore gating glutamate residue; other site 155864009260 dimer interface [polypeptide binding]; other site 155864009261 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 155864009262 manganese transport protein MntH; Reviewed; Region: PRK00701 155864009263 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 155864009264 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 155864009265 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 155864009266 Nucleoside recognition; Region: Gate; pfam07670 155864009267 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 155864009268 MASE1; Region: MASE1; pfam05231 155864009269 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 155864009270 diguanylate cyclase; Region: GGDEF; smart00267 155864009271 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 155864009272 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 155864009273 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 155864009274 salt bridge; other site 155864009275 non-specific DNA binding site [nucleotide binding]; other site 155864009276 sequence-specific DNA binding site [nucleotide binding]; other site 155864009277 O-island #103; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864009278 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 155864009279 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 155864009280 Probable transposase; Region: OrfB_IS605; pfam01385 155864009281 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 155864009282 O-island #103; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864009283 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 155864009284 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 155864009285 active site 155864009286 HIGH motif; other site 155864009287 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 155864009288 active site 155864009289 KMSKS motif; other site 155864009290 O-island #104; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864009291 Transcriptional regulator [Transcription]; Region: LysR; COG0583 155864009292 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 155864009293 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 155864009294 putative dimerization interface [polypeptide binding]; other site 155864009295 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 155864009296 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 155864009297 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 155864009298 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 155864009299 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 155864009300 nucleotide binding pocket [chemical binding]; other site 155864009301 K-X-D-G motif; other site 155864009302 catalytic site [active] 155864009303 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 155864009304 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 155864009305 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 155864009306 Dimer interface [polypeptide binding]; other site 155864009307 BRCT sequence motif; other site 155864009308 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 155864009309 cell division protein ZipA; Provisional; Region: PRK03427 155864009310 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 155864009311 FtsZ protein binding site [polypeptide binding]; other site 155864009312 putative sulfate transport protein CysZ; Validated; Region: PRK04949 155864009313 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 155864009314 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 155864009315 dimer interface [polypeptide binding]; other site 155864009316 pyridoxal 5'-phosphate binding site [chemical binding]; other site 155864009317 catalytic residue [active] 155864009318 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 155864009319 dimerization domain swap beta strand [polypeptide binding]; other site 155864009320 regulatory protein interface [polypeptide binding]; other site 155864009321 active site 155864009322 regulatory phosphorylation site [posttranslational modification]; other site 155864009323 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 155864009324 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 155864009325 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 155864009326 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 155864009327 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 155864009328 HPr interaction site; other site 155864009329 glycerol kinase (GK) interaction site [polypeptide binding]; other site 155864009330 active site 155864009331 phosphorylation site [posttranslational modification] 155864009332 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 155864009333 dimer interface [polypeptide binding]; other site 155864009334 pyridoxamine kinase; Validated; Region: PRK05756 155864009335 pyridoxal binding site [chemical binding]; other site 155864009336 ATP binding site [chemical binding]; other site 155864009337 hypothetical protein; Provisional; Region: PRK10318 155864009338 cysteine synthase B; Region: cysM; TIGR01138 155864009339 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 155864009340 dimer interface [polypeptide binding]; other site 155864009341 pyridoxal 5'-phosphate binding site [chemical binding]; other site 155864009342 catalytic residue [active] 155864009343 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 155864009344 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 155864009345 Walker A/P-loop; other site 155864009346 ATP binding site [chemical binding]; other site 155864009347 Q-loop/lid; other site 155864009348 ABC transporter signature motif; other site 155864009349 Walker B; other site 155864009350 D-loop; other site 155864009351 H-loop/switch region; other site 155864009352 TOBE-like domain; Region: TOBE_3; pfam12857 155864009353 sulfate transport protein; Provisional; Region: cysT; CHL00187 155864009354 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 155864009355 dimer interface [polypeptide binding]; other site 155864009356 conserved gate region; other site 155864009357 putative PBP binding loops; other site 155864009358 ABC-ATPase subunit interface; other site 155864009359 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 155864009360 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 155864009361 dimer interface [polypeptide binding]; other site 155864009362 conserved gate region; other site 155864009363 putative PBP binding loops; other site 155864009364 ABC-ATPase subunit interface; other site 155864009365 thiosulfate transporter subunit; Provisional; Region: PRK10852 155864009366 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 155864009367 short chain dehydrogenase; Provisional; Region: PRK08226 155864009368 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 155864009369 NAD binding site [chemical binding]; other site 155864009370 homotetramer interface [polypeptide binding]; other site 155864009371 homodimer interface [polypeptide binding]; other site 155864009372 active site 155864009373 transcriptional regulator MurR; Provisional; Region: PRK15482 155864009374 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 155864009375 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 155864009376 putative active site [active] 155864009377 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 155864009378 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 155864009379 putative active site [active] 155864009380 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 155864009381 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 155864009382 active site turn [active] 155864009383 phosphorylation site [posttranslational modification] 155864009384 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 155864009385 putative periplasmic esterase; Provisional; Region: PRK03642 155864009386 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 155864009387 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 155864009388 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 155864009389 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 155864009390 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 155864009391 putative acetyltransferase; Provisional; Region: PRK03624 155864009392 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 155864009393 Coenzyme A binding pocket [chemical binding]; other site 155864009394 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 155864009395 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 155864009396 active site 155864009397 metal binding site [ion binding]; metal-binding site 155864009398 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 155864009399 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 155864009400 transcriptional regulator EutR; Provisional; Region: PRK10130 155864009401 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 155864009402 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 155864009403 carboxysome structural protein EutK; Provisional; Region: PRK15466 155864009404 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 155864009405 Hexamer interface [polypeptide binding]; other site 155864009406 Hexagonal pore residue; other site 155864009407 FaeA-like protein; Region: FaeA; pfam04703 155864009408 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 155864009409 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 155864009410 putative hexamer interface [polypeptide binding]; other site 155864009411 putative hexagonal pore; other site 155864009412 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 155864009413 putative hexamer interface [polypeptide binding]; other site 155864009414 putative hexagonal pore; other site 155864009415 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 155864009416 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 155864009417 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 155864009418 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 155864009419 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 155864009420 ethanol dehydrogenase EutG; Provisional; Region: PRK15454 155864009421 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 155864009422 active site 155864009423 metal binding site [ion binding]; metal-binding site 155864009424 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 155864009425 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 155864009426 nucleotide binding site [chemical binding]; other site 155864009427 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 155864009428 putative catalytic cysteine [active] 155864009429 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 155864009430 Hexamer/Pentamer interface [polypeptide binding]; other site 155864009431 central pore; other site 155864009432 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 155864009433 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 155864009434 Hexamer interface [polypeptide binding]; other site 155864009435 Putative hexagonal pore residue; other site 155864009436 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 155864009437 ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020 155864009438 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 155864009439 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766 155864009440 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 155864009441 G1 box; other site 155864009442 GTP/Mg2+ binding site [chemical binding]; other site 155864009443 G2 box; other site 155864009444 Switch I region; other site 155864009445 G3 box; other site 155864009446 Switch II region; other site 155864009447 G4 box; other site 155864009448 G5 box; other site 155864009449 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 155864009450 putative hexamer interface [polypeptide binding]; other site 155864009451 putative hexagonal pore; other site 155864009452 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 155864009453 Malic enzyme, N-terminal domain; Region: malic; pfam00390 155864009454 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 155864009455 putative NAD(P) binding site [chemical binding]; other site 155864009456 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 155864009457 transaldolase-like protein; Provisional; Region: PTZ00411 155864009458 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 155864009459 active site 155864009460 dimer interface [polypeptide binding]; other site 155864009461 catalytic residue [active] 155864009462 transketolase; Reviewed; Region: PRK12753 155864009463 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 155864009464 TPP-binding site [chemical binding]; other site 155864009465 dimer interface [polypeptide binding]; other site 155864009466 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 155864009467 PYR/PP interface [polypeptide binding]; other site 155864009468 dimer interface [polypeptide binding]; other site 155864009469 TPP binding site [chemical binding]; other site 155864009470 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 155864009471 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 155864009472 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 155864009473 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 155864009474 dimer interface [polypeptide binding]; other site 155864009475 ADP-ribose binding site [chemical binding]; other site 155864009476 active site 155864009477 nudix motif; other site 155864009478 metal binding site [ion binding]; metal-binding site 155864009479 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 155864009480 4Fe-4S binding domain; Region: Fer4; pfam00037 155864009481 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 155864009482 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 155864009483 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 155864009484 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 155864009485 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 155864009486 dimerization interface [polypeptide binding]; other site 155864009487 Histidine kinase; Region: HisKA_3; pfam07730 155864009488 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 155864009489 ATP binding site [chemical binding]; other site 155864009490 Mg2+ binding site [ion binding]; other site 155864009491 G-X-G motif; other site 155864009492 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 155864009493 Protein export membrane protein; Region: SecD_SecF; cl14618 155864009494 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 155864009495 ArsC family; Region: ArsC; pfam03960 155864009496 putative catalytic residues [active] 155864009497 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 155864009498 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 155864009499 metal binding site [ion binding]; metal-binding site 155864009500 dimer interface [polypeptide binding]; other site 155864009501 hypothetical protein; Provisional; Region: PRK13664 155864009502 O-island #105; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864009503 O-island #105; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864009504 putative hydrolase; Provisional; Region: PRK11460 155864009505 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 155864009506 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 155864009507 Helicase; Region: Helicase_RecD; pfam05127 155864009508 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 155864009509 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 155864009510 Predicted metalloprotease [General function prediction only]; Region: COG2321 155864009511 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 155864009512 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 155864009513 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 155864009514 ATP binding site [chemical binding]; other site 155864009515 active site 155864009516 substrate binding site [chemical binding]; other site 155864009517 lipoprotein; Provisional; Region: PRK11679 155864009518 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 155864009519 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 155864009520 dihydrodipicolinate synthase; Region: dapA; TIGR00674 155864009521 dimer interface [polypeptide binding]; other site 155864009522 active site 155864009523 catalytic residue [active] 155864009524 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 155864009525 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 155864009526 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 155864009527 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 155864009528 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 155864009529 catalytic triad [active] 155864009530 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 155864009531 4Fe-4S binding domain; Region: Fer4; pfam00037 155864009532 hydrogenase 4 subunit B; Validated; Region: PRK06521 155864009533 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 155864009534 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 155864009535 NADH dehydrogenase; Region: NADHdh; cl00469 155864009536 hydrogenase 4 subunit D; Validated; Region: PRK06525 155864009537 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 155864009538 hydrogenase 4 membrane subunit; Provisional; Region: hyfE; PRK11492 155864009539 hydrogenase 4 subunit F; Validated; Region: PRK06458 155864009540 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 155864009541 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 155864009542 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 155864009543 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 155864009544 hydrogenase 4 subunit H; Validated; Region: PRK08222 155864009545 4Fe-4S binding domain; Region: Fer4; pfam00037 155864009546 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 155864009547 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 155864009548 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 155864009549 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 155864009550 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 155864009551 Walker A motif; other site 155864009552 ATP binding site [chemical binding]; other site 155864009553 Walker B motif; other site 155864009554 arginine finger; other site 155864009555 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 155864009556 putative formate transporter; Provisional; Region: focB; PRK09713 155864009557 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 155864009558 Domain of unknown function DUF20; Region: UPF0118; pfam01594 155864009559 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 155864009560 Peptidase family M48; Region: Peptidase_M48; cl12018 155864009561 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 155864009562 ArsC family; Region: ArsC; pfam03960 155864009563 catalytic residues [active] 155864009564 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 155864009565 DNA replication initiation factor; Provisional; Region: PRK08084 155864009566 uracil transporter; Provisional; Region: PRK10720 155864009567 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 155864009568 active site 155864009569 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 155864009570 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 155864009571 dimerization interface [polypeptide binding]; other site 155864009572 putative ATP binding site [chemical binding]; other site 155864009573 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 155864009574 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 155864009575 active site 155864009576 substrate binding site [chemical binding]; other site 155864009577 cosubstrate binding site; other site 155864009578 catalytic site [active] 155864009579 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 155864009580 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 155864009581 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 155864009582 Catalytic C-terminal domain, first repeat, of prokaryotic polyphosphate kinase 1 and similar proteins; Region: PLDc_PPK1_C1; cd09114 155864009583 domain interface [polypeptide binding]; other site 155864009584 active site 155864009585 catalytic site [active] 155864009586 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 155864009587 putative active site [active] 155864009588 catalytic site [active] 155864009589 exopolyphosphatase; Provisional; Region: PRK10854 155864009590 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 155864009591 MASE1; Region: MASE1; pfam05231 155864009592 diguanylate cyclase; Region: GGDEF; smart00267 155864009593 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 155864009594 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 155864009595 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 155864009596 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 155864009597 GMP synthase; Reviewed; Region: guaA; PRK00074 155864009598 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 155864009599 AMP/PPi binding site [chemical binding]; other site 155864009600 candidate oxyanion hole; other site 155864009601 catalytic triad [active] 155864009602 potential glutamine specificity residues [chemical binding]; other site 155864009603 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 155864009604 ATP Binding subdomain [chemical binding]; other site 155864009605 Ligand Binding sites [chemical binding]; other site 155864009606 Dimerization subdomain; other site 155864009607 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 155864009608 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 155864009609 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 155864009610 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 155864009611 active site 155864009612 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 155864009613 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 155864009614 generic binding surface II; other site 155864009615 generic binding surface I; other site 155864009616 GTP-binding protein Der; Reviewed; Region: PRK00093 155864009617 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 155864009618 G1 box; other site 155864009619 GTP/Mg2+ binding site [chemical binding]; other site 155864009620 Switch I region; other site 155864009621 G2 box; other site 155864009622 Switch II region; other site 155864009623 G3 box; other site 155864009624 G4 box; other site 155864009625 G5 box; other site 155864009626 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 155864009627 G1 box; other site 155864009628 GTP/Mg2+ binding site [chemical binding]; other site 155864009629 Switch I region; other site 155864009630 G2 box; other site 155864009631 G3 box; other site 155864009632 Switch II region; other site 155864009633 G4 box; other site 155864009634 G5 box; other site 155864009635 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 155864009636 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cd00216 155864009637 Trp docking motif [polypeptide binding]; other site 155864009638 active site 155864009639 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 155864009640 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 155864009641 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 155864009642 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 155864009643 dimer interface [polypeptide binding]; other site 155864009644 motif 1; other site 155864009645 active site 155864009646 motif 2; other site 155864009647 motif 3; other site 155864009648 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 155864009649 anticodon binding site; other site 155864009650 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 155864009651 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 155864009652 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 155864009653 cytoskeletal protein RodZ; Provisional; Region: PRK10856 155864009654 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 155864009655 non-specific DNA binding site [nucleotide binding]; other site 155864009656 salt bridge; other site 155864009657 sequence-specific DNA binding site [nucleotide binding]; other site 155864009658 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 155864009659 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 155864009660 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 155864009661 FeS/SAM binding site; other site 155864009662 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 155864009663 active site 155864009664 multimer interface [polypeptide binding]; other site 155864009665 O-island #106; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864009666 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 155864009667 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 155864009668 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 155864009669 4Fe-4S binding domain; Region: Fer4; pfam00037 155864009670 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 155864009671 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 155864009672 putative [Fe4-S4] binding site [ion binding]; other site 155864009673 putative molybdopterin cofactor binding site [chemical binding]; other site 155864009674 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 155864009675 putative molybdopterin cofactor binding site; other site 155864009676 penicillin-binding protein 1C; Provisional; Region: PRK11240 155864009677 Transglycosylase; Region: Transgly; pfam00912 155864009678 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 155864009679 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 155864009680 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 155864009681 MG2 domain; Region: A2M_N; pfam01835 155864009682 Alpha-2-macroglobulin family; Region: A2M; pfam00207 155864009683 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 155864009684 surface patch; other site 155864009685 thioester region; other site 155864009686 specificity defining residues; other site 155864009687 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 155864009688 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 155864009689 active site residue [active] 155864009690 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 155864009691 active site residue [active] 155864009692 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 155864009693 aminopeptidase B; Provisional; Region: PRK05015 155864009694 Peptidase; Region: DUF3663; pfam12404 155864009695 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 155864009696 interface (dimer of trimers) [polypeptide binding]; other site 155864009697 Substrate-binding/catalytic site; other site 155864009698 Zn-binding sites [ion binding]; other site 155864009699 hypothetical protein; Provisional; Region: PRK10721 155864009700 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 155864009701 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 155864009702 catalytic loop [active] 155864009703 iron binding site [ion binding]; other site 155864009704 chaperone protein HscA; Provisional; Region: hscA; PRK05183 155864009705 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 155864009706 nucleotide binding site [chemical binding]; other site 155864009707 putative NEF/HSP70 interaction site [polypeptide binding]; other site 155864009708 SBD interface [polypeptide binding]; other site 155864009709 co-chaperone HscB; Provisional; Region: hscB; PRK05014 155864009710 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 155864009711 HSP70 interaction site [polypeptide binding]; other site 155864009712 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 155864009713 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 155864009714 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 155864009715 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 155864009716 trimerization site [polypeptide binding]; other site 155864009717 active site 155864009718 cysteine desulfurase; Provisional; Region: PRK14012 155864009719 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 155864009720 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 155864009721 catalytic residue [active] 155864009722 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 155864009723 Rrf2 family protein; Region: rrf2_super; TIGR00738 155864009724 O-island #107; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864009725 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 155864009726 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 155864009727 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 155864009728 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 155864009729 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 155864009730 PRD domain; Region: PRD; pfam00874 155864009731 PRD domain; Region: PRD; pfam00874 155864009732 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 155864009733 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864009734 putative substrate translocation pore; other site 155864009735 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 155864009736 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 155864009737 The C-terminal substrate binding domain of LysR-type transcriptional regulator HcaR in involved in 3-phenylpropionic acid catabolism, contains the type2 periplasmic binding fold; Region: PBP2_HcaR; cd08450 155864009738 putative dimerization interface [polypeptide binding]; other site 155864009739 putative substrate binding pocket [chemical binding]; other site 155864009740 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 155864009741 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 155864009742 iron-sulfur cluster [ion binding]; other site 155864009743 [2Fe-2S] cluster binding site [ion binding]; other site 155864009744 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 155864009745 beta subunit interface [polypeptide binding]; other site 155864009746 alpha subunit interface [polypeptide binding]; other site 155864009747 active site 155864009748 substrate binding site [chemical binding]; other site 155864009749 Fe binding site [ion binding]; other site 155864009750 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 155864009751 inter-subunit interface; other site 155864009752 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 155864009753 [2Fe-2S] cluster binding site [ion binding]; other site 155864009754 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 155864009755 cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase (BphB)-like, classical (c) SDRs; Region: BphB-like_SDR_c; cd05348 155864009756 NAD binding site [chemical binding]; other site 155864009757 active site 155864009758 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 155864009759 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 155864009760 Predicted membrane protein [Function unknown]; Region: COG2259 155864009761 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 155864009762 active site 155864009763 catalytic residues [active] 155864009764 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 155864009765 L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239 155864009766 putative NAD(P) binding site [chemical binding]; other site 155864009767 catalytic Zn binding site [ion binding]; other site 155864009768 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 155864009769 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 155864009770 TM-ABC transporter signature motif; other site 155864009771 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 155864009772 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 155864009773 Walker A/P-loop; other site 155864009774 ATP binding site [chemical binding]; other site 155864009775 Q-loop/lid; other site 155864009776 ABC transporter signature motif; other site 155864009777 Walker B; other site 155864009778 D-loop; other site 155864009779 H-loop/switch region; other site 155864009780 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 155864009781 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 155864009782 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 155864009783 ligand binding site [chemical binding]; other site 155864009784 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 155864009785 TPR motif; other site 155864009786 Tetratricopeptide repeat; Region: TPR_16; pfam13432 155864009787 binding surface 155864009788 TPR repeat; Region: TPR_11; pfam13414 155864009789 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 155864009790 TPR motif; other site 155864009791 binding surface 155864009792 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 155864009793 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 155864009794 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 155864009795 nucleotide binding site [chemical binding]; other site 155864009796 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 155864009797 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 155864009798 dimer interface [polypeptide binding]; other site 155864009799 active site 155864009800 glycine-pyridoxal phosphate binding site [chemical binding]; other site 155864009801 folate binding site [chemical binding]; other site 155864009802 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 155864009803 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 155864009804 heme-binding site [chemical binding]; other site 155864009805 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 155864009806 FAD binding pocket [chemical binding]; other site 155864009807 FAD binding motif [chemical binding]; other site 155864009808 phosphate binding motif [ion binding]; other site 155864009809 beta-alpha-beta structure motif; other site 155864009810 NAD binding pocket [chemical binding]; other site 155864009811 Heme binding pocket [chemical binding]; other site 155864009812 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 155864009813 Nitrogen regulatory protein P-II; Region: P-II; smart00938 155864009814 response regulator GlrR; Provisional; Region: PRK15115 155864009815 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 155864009816 active site 155864009817 phosphorylation site [posttranslational modification] 155864009818 intermolecular recognition site; other site 155864009819 dimerization interface [polypeptide binding]; other site 155864009820 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 155864009821 Walker A motif; other site 155864009822 ATP binding site [chemical binding]; other site 155864009823 Walker B motif; other site 155864009824 arginine finger; other site 155864009825 hypothetical protein; Provisional; Region: PRK10722 155864009826 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 155864009827 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 155864009828 dimer interface [polypeptide binding]; other site 155864009829 phosphorylation site [posttranslational modification] 155864009830 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 155864009831 ATP binding site [chemical binding]; other site 155864009832 Mg2+ binding site [ion binding]; other site 155864009833 G-X-G motif; other site 155864009834 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 155864009835 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 155864009836 dimerization interface [polypeptide binding]; other site 155864009837 ATP binding site [chemical binding]; other site 155864009838 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 155864009839 dimerization interface [polypeptide binding]; other site 155864009840 ATP binding site [chemical binding]; other site 155864009841 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 155864009842 putative active site [active] 155864009843 catalytic triad [active] 155864009844 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 155864009845 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 155864009846 substrate binding pocket [chemical binding]; other site 155864009847 membrane-bound complex binding site; other site 155864009848 hinge residues; other site 155864009849 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 155864009850 N-acetyl-D-glucosamine binding site [chemical binding]; other site 155864009851 catalytic residue [active] 155864009852 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 155864009853 nucleoside/Zn binding site; other site 155864009854 dimer interface [polypeptide binding]; other site 155864009855 catalytic motif [active] 155864009856 hypothetical protein; Provisional; Region: PRK11590 155864009857 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 155864009858 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 155864009859 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 155864009860 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 155864009861 putative active site [active] 155864009862 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 155864009863 holo-[acyl-carrier-protein] synthase; Region: acpS; TIGR00516 155864009864 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 155864009865 active site 155864009866 hydrophilic channel; other site 155864009867 dimerization interface [polypeptide binding]; other site 155864009868 catalytic residues [active] 155864009869 active site lid [active] 155864009870 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 155864009871 Recombination protein O N terminal; Region: RecO_N; pfam11967 155864009872 Recombination protein O C terminal; Region: RecO_C; pfam02565 155864009873 GTPase Era; Reviewed; Region: era; PRK00089 155864009874 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 155864009875 G1 box; other site 155864009876 GTP/Mg2+ binding site [chemical binding]; other site 155864009877 Switch I region; other site 155864009878 G2 box; other site 155864009879 Switch II region; other site 155864009880 G3 box; other site 155864009881 G4 box; other site 155864009882 G5 box; other site 155864009883 KH domain; Region: KH_2; pfam07650 155864009884 ribonuclease III; Reviewed; Region: rnc; PRK00102 155864009885 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 155864009886 dimerization interface [polypeptide binding]; other site 155864009887 active site 155864009888 metal binding site [ion binding]; metal-binding site 155864009889 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 155864009890 dsRNA binding site [nucleotide binding]; other site 155864009891 signal peptidase I; Provisional; Region: PRK10861 155864009892 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 155864009893 Catalytic site [active] 155864009894 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 155864009895 GTP-binding protein LepA; Provisional; Region: PRK05433 155864009896 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 155864009897 G1 box; other site 155864009898 putative GEF interaction site [polypeptide binding]; other site 155864009899 GTP/Mg2+ binding site [chemical binding]; other site 155864009900 Switch I region; other site 155864009901 G2 box; other site 155864009902 G3 box; other site 155864009903 Switch II region; other site 155864009904 G4 box; other site 155864009905 G5 box; other site 155864009906 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 155864009907 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 155864009908 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 155864009909 SoxR reducing system protein RseC; Provisional; Region: PRK10862 155864009910 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 155864009911 anti-sigma E factor; Provisional; Region: rseB; PRK09455 155864009912 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 155864009913 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 155864009914 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 155864009915 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 155864009916 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 155864009917 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 155864009918 DNA binding residues [nucleotide binding] 155864009919 L-aspartate oxidase; Provisional; Region: PRK09077 155864009920 L-aspartate oxidase; Provisional; Region: PRK06175 155864009921 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 155864009922 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 155864009923 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 155864009924 S-adenosylmethionine binding site [chemical binding]; other site 155864009925 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 155864009926 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 155864009927 ATP binding site [chemical binding]; other site 155864009928 Mg++ binding site [ion binding]; other site 155864009929 motif III; other site 155864009930 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 155864009931 nucleotide binding region [chemical binding]; other site 155864009932 ATP-binding site [chemical binding]; other site 155864009933 Transcriptional regulator [Transcription]; Region: LysR; COG0583 155864009934 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 155864009935 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 155864009936 dimerization interface [polypeptide binding]; other site 155864009937 cysteine/O-acetylserine exporter; Provisional; Region: PRK10323 155864009938 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 155864009939 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 155864009940 ligand binding site [chemical binding]; other site 155864009941 active site 155864009942 UGI interface [polypeptide binding]; other site 155864009943 catalytic site [active] 155864009944 putative methyltransferase; Provisional; Region: PRK10864 155864009945 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 155864009946 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 155864009947 thioredoxin 2; Provisional; Region: PRK10996 155864009948 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 155864009949 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 155864009950 catalytic residues [active] 155864009951 Uncharacterized conserved protein [Function unknown]; Region: COG3148 155864009952 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 155864009953 CoA binding domain; Region: CoA_binding_2; pfam13380 155864009954 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 155864009955 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 155864009956 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 155864009957 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 155864009958 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 155864009959 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 155864009960 domain interface [polypeptide binding]; other site 155864009961 putative active site [active] 155864009962 catalytic site [active] 155864009963 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 155864009964 domain interface [polypeptide binding]; other site 155864009965 putative active site [active] 155864009966 catalytic site [active] 155864009967 lipoprotein; Provisional; Region: PRK10759 155864009968 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 155864009969 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864009970 putative substrate translocation pore; other site 155864009971 protein disaggregation chaperone; Provisional; Region: PRK10865 155864009972 Clp amino terminal domain; Region: Clp_N; pfam02861 155864009973 Clp amino terminal domain; Region: Clp_N; pfam02861 155864009974 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 155864009975 Walker A motif; other site 155864009976 ATP binding site [chemical binding]; other site 155864009977 Walker B motif; other site 155864009978 arginine finger; other site 155864009979 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 155864009980 Walker A motif; other site 155864009981 ATP binding site [chemical binding]; other site 155864009982 Walker B motif; other site 155864009983 arginine finger; other site 155864009984 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 155864009985 hypothetical protein; Provisional; Region: PRK10723 155864009986 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 155864009987 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 155864009988 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 155864009989 RNA binding surface [nucleotide binding]; other site 155864009990 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 155864009991 active site 155864009992 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 155864009993 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 155864009994 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 155864009995 30S subunit binding site; other site 155864009996 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 155864009997 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 155864009998 Prephenate dehydratase; Region: PDT; pfam00800 155864009999 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 155864010000 putative L-Phe binding site [chemical binding]; other site 155864010001 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 155864010002 Chorismate mutase type II; Region: CM_2; cl00693 155864010003 prephenate dehydrogenase; Validated; Region: PRK08507 155864010004 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 155864010005 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 155864010006 lipoprotein; Provisional; Region: PRK11443 155864010007 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 155864010008 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 155864010009 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 155864010010 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 155864010011 metal binding site [ion binding]; metal-binding site 155864010012 active site 155864010013 I-site; other site 155864010014 putative outer membrane lipoprotein; Provisional; Region: PRK09967 155864010015 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 155864010016 ligand binding site [chemical binding]; other site 155864010017 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 155864010018 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 155864010019 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 155864010020 RimM N-terminal domain; Region: RimM; pfam01782 155864010021 PRC-barrel domain; Region: PRC; pfam05239 155864010022 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 155864010023 signal recognition particle protein; Provisional; Region: PRK10867 155864010024 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 155864010025 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 155864010026 P loop; other site 155864010027 GTP binding site [chemical binding]; other site 155864010028 Signal peptide binding domain; Region: SRP_SPB; pfam02978 155864010029 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 155864010030 hypothetical protein; Provisional; Region: PRK11573 155864010031 Domain of unknown function DUF21; Region: DUF21; pfam01595 155864010032 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 155864010033 Transporter associated domain; Region: CorC_HlyC; smart01091 155864010034 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 155864010035 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 155864010036 dimer interface [polypeptide binding]; other site 155864010037 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 155864010038 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 155864010039 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 155864010040 recombination and repair protein; Provisional; Region: PRK10869 155864010041 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 155864010042 Walker A/P-loop; other site 155864010043 ATP binding site [chemical binding]; other site 155864010044 Q-loop/lid; other site 155864010045 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 155864010046 Q-loop/lid; other site 155864010047 ABC transporter signature motif; other site 155864010048 Walker B; other site 155864010049 D-loop; other site 155864010050 H-loop/switch region; other site 155864010051 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 155864010052 hypothetical protein; Validated; Region: PRK01777 155864010053 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 155864010054 putative coenzyme Q binding site [chemical binding]; other site 155864010055 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 155864010056 SmpB-tmRNA interface; other site 155864010057 O-island #108; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864010058 DinI-like family; Region: DinI; pfam06183 155864010059 O-island #108; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864010060 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 155864010061 IpaB/EvcA family; Region: IpaB_EvcA; pfam03278 155864010062 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 155864010063 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 155864010064 Transposase; Region: HTH_Tnp_1; cl17663 155864010065 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 155864010066 putative transposase OrfB; Reviewed; Region: PHA02517 155864010067 Integrase core domain; Region: rve; pfam00665 155864010068 Integrase core domain; Region: rve; pfam00665 155864010069 Integrase core domain; Region: rve_3; pfam13683 155864010070 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 155864010071 Domain of unknown function (DUF303); Region: DUF303; pfam03629 155864010072 Protein of unknown function (DUF3927); Region: DUF3927; pfam13064 155864010073 Antitermination protein; Region: Antiterm; pfam03589 155864010074 Antitermination protein; Region: Antiterm; pfam03589 155864010075 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 155864010076 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 155864010077 active site 155864010078 metal binding site [ion binding]; metal-binding site 155864010079 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 155864010080 O-island #108; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864010081 HNH endonuclease; Region: HNH_3; pfam13392 155864010082 AP2 domain; Region: AP2; pfam00847 155864010083 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 155864010084 DNA-binding interface [nucleotide binding]; DNA binding site 155864010085 Helix-turn-helix domain; Region: HTH_38; pfam13936 155864010086 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 155864010087 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4688 155864010088 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 155864010089 active site 155864010090 catalytic residues [active] 155864010091 DNA binding site [nucleotide binding] 155864010092 Int/Topo IB signature motif; other site 155864010093 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 155864010094 active site 155864010095 catalytic residues [active] 155864010096 Int/Topo IB signature motif; other site 155864010097 DNA binding site [nucleotide binding] 155864010098 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 155864010099 O-island #108; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864010100 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 155864010101 hypothetical protein; Provisional; Region: PRK09945 155864010102 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 155864010103 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 155864010104 Autotransporter beta-domain; Region: Autotransporter; pfam03797 155864010105 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 155864010106 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 155864010107 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 155864010108 active site 155864010109 catalytic site [active] 155864010110 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 155864010111 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 155864010112 substrate binding pocket [chemical binding]; other site 155864010113 active site 155864010114 iron coordination sites [ion binding]; other site 155864010115 Predicted dehydrogenase [General function prediction only]; Region: COG0579 155864010116 hydroxyglutarate oxidase; Provisional; Region: PRK11728 155864010117 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 155864010118 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 155864010119 tetramerization interface [polypeptide binding]; other site 155864010120 NAD(P) binding site [chemical binding]; other site 155864010121 catalytic residues [active] 155864010122 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 155864010123 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 155864010124 inhibitor-cofactor binding pocket; inhibition site 155864010125 pyridoxal 5'-phosphate binding site [chemical binding]; other site 155864010126 catalytic residue [active] 155864010127 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 155864010128 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 155864010129 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 155864010130 DNA-binding site [nucleotide binding]; DNA binding site 155864010131 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 155864010132 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 155864010133 bacterial OsmY and nodulation domain; Region: BON; smart00749 155864010134 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 155864010135 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 155864010136 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 155864010137 dimerization interface [polypeptide binding]; other site 155864010138 putative DNA binding site [nucleotide binding]; other site 155864010139 Transcriptional regulators [Transcription]; Region: MarR; COG1846 155864010140 putative Zn2+ binding site [ion binding]; other site 155864010141 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YgaP, and similar uncharacterized putative rhodanese-related sulfurtransferases; Region: RHOD_YgaP; cd01527 155864010142 active site residue [active] 155864010143 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 155864010144 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 155864010145 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 155864010146 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 155864010147 hypothetical protein; Provisional; Region: PRK10556 155864010148 hypothetical protein; Provisional; Region: PRK10132 155864010149 O-island #109; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864010150 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 155864010151 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 155864010152 DNA-binding site [nucleotide binding]; DNA binding site 155864010153 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 155864010154 pyridoxal 5'-phosphate binding site [chemical binding]; other site 155864010155 homodimer interface [polypeptide binding]; other site 155864010156 catalytic residue [active] 155864010157 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 155864010158 Uncharacterized conserved protein [Function unknown]; Region: COG2128 155864010159 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 155864010160 catalytic residues [active] 155864010161 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 155864010162 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 155864010163 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 155864010164 Class I ribonucleotide reductase; Region: RNR_I; cd01679 155864010165 active site 155864010166 dimer interface [polypeptide binding]; other site 155864010167 catalytic residues [active] 155864010168 effector binding site; other site 155864010169 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 155864010170 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 155864010171 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 155864010172 dimer interface [polypeptide binding]; other site 155864010173 putative radical transfer pathway; other site 155864010174 diiron center [ion binding]; other site 155864010175 tyrosyl radical; other site 155864010176 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 155864010177 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 155864010178 Walker A/P-loop; other site 155864010179 ATP binding site [chemical binding]; other site 155864010180 Q-loop/lid; other site 155864010181 ABC transporter signature motif; other site 155864010182 Walker B; other site 155864010183 D-loop; other site 155864010184 H-loop/switch region; other site 155864010185 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 155864010186 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 155864010187 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 155864010188 dimer interface [polypeptide binding]; other site 155864010189 conserved gate region; other site 155864010190 putative PBP binding loops; other site 155864010191 ABC-ATPase subunit interface; other site 155864010192 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 155864010193 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 155864010194 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 155864010195 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864010196 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 155864010197 putative L-valine exporter; Provisional; Region: PRK10408 155864010198 transcriptional repressor MprA; Provisional; Region: PRK10870 155864010199 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 155864010200 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 155864010201 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 155864010202 HlyD family secretion protein; Region: HlyD_3; pfam13437 155864010203 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 155864010204 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864010205 putative substrate translocation pore; other site 155864010206 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864010207 S-ribosylhomocysteinase; Provisional; Region: PRK02260 155864010208 glutamate--cysteine ligase; Provisional; Region: PRK02107 155864010209 Predicted membrane protein [Function unknown]; Region: COG1238 155864010210 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 155864010211 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 155864010212 motif II; other site 155864010213 carbon storage regulator; Provisional; Region: PRK01712 155864010214 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 155864010215 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 155864010216 motif 1; other site 155864010217 active site 155864010218 motif 2; other site 155864010219 motif 3; other site 155864010220 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 155864010221 DHHA1 domain; Region: DHHA1; pfam02272 155864010222 recombination regulator RecX; Reviewed; Region: recX; PRK00117 155864010223 recombinase A; Provisional; Region: recA; PRK09354 155864010224 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 155864010225 hexamer interface [polypeptide binding]; other site 155864010226 Walker A motif; other site 155864010227 ATP binding site [chemical binding]; other site 155864010228 Walker B motif; other site 155864010229 hypothetical protein; Validated; Region: PRK03661 155864010230 Transglycosylase SLT domain; Region: SLT_2; pfam13406 155864010231 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 155864010232 N-acetyl-D-glucosamine binding site [chemical binding]; other site 155864010233 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; cl01515 155864010234 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; cl01515 155864010235 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 155864010236 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 155864010237 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 155864010238 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 155864010239 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 155864010240 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 155864010241 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 155864010242 putative NAD(P) binding site [chemical binding]; other site 155864010243 active site 155864010244 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 155864010245 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 155864010246 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 155864010247 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 155864010248 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 155864010249 putative active site [active] 155864010250 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 155864010251 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 155864010252 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 155864010253 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 155864010254 Walker A motif; other site 155864010255 ATP binding site [chemical binding]; other site 155864010256 Walker B motif; other site 155864010257 arginine finger; other site 155864010258 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 155864010259 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 155864010260 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 155864010261 Rubredoxin [Energy production and conversion]; Region: COG1773 155864010262 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 155864010263 iron binding site [ion binding]; other site 155864010264 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 155864010265 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 155864010266 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 155864010267 Acylphosphatase; Region: Acylphosphatase; pfam00708 155864010268 HypF finger; Region: zf-HYPF; pfam07503 155864010269 HypF finger; Region: zf-HYPF; pfam07503 155864010270 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 155864010271 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 155864010272 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 155864010273 Transcriptional regulators [Transcription]; Region: PurR; COG1609 155864010274 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 155864010275 DNA binding site [nucleotide binding] 155864010276 domain linker motif; other site 155864010277 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 155864010278 dimerization interface (closed form) [polypeptide binding]; other site 155864010279 ligand binding site [chemical binding]; other site 155864010280 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 155864010281 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 155864010282 active site turn [active] 155864010283 phosphorylation site [posttranslational modification] 155864010284 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 155864010285 cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852 155864010286 beta-galactosidase; Region: BGL; TIGR03356 155864010287 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 155864010288 nickel binding site [ion binding]; other site 155864010289 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 155864010290 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 155864010291 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 155864010292 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 155864010293 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 155864010294 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 155864010295 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 155864010296 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 155864010297 NADH dehydrogenase; Region: NADHdh; cl00469 155864010298 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 155864010299 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 155864010300 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 155864010301 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 155864010302 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 155864010303 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 155864010304 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 155864010305 hydrogenase assembly chaperone; Provisional; Region: PRK10409 155864010306 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 155864010307 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 155864010308 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 155864010309 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 155864010310 dimerization interface [polypeptide binding]; other site 155864010311 ATP binding site [chemical binding]; other site 155864010312 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 155864010313 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 155864010314 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 155864010315 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 155864010316 Walker A motif; other site 155864010317 ATP binding site [chemical binding]; other site 155864010318 Walker B motif; other site 155864010319 arginine finger; other site 155864010320 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 155864010321 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 155864010322 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 155864010323 MutS domain I; Region: MutS_I; pfam01624 155864010324 MutS domain II; Region: MutS_II; pfam05188 155864010325 MutS domain III; Region: MutS_III; pfam05192 155864010326 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 155864010327 Walker A/P-loop; other site 155864010328 ATP binding site [chemical binding]; other site 155864010329 Q-loop/lid; other site 155864010330 ABC transporter signature motif; other site 155864010331 Walker B; other site 155864010332 D-loop; other site 155864010333 H-loop/switch region; other site 155864010334 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 155864010335 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 155864010336 active site 155864010337 metal binding site [ion binding]; metal-binding site 155864010338 O-island #110; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864010339 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 155864010340 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 155864010341 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 155864010342 Flavoprotein; Region: Flavoprotein; pfam02441 155864010343 O-island #110; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864010344 MarR family; Region: MarR_2; cl17246 155864010345 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 155864010346 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 155864010347 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 155864010348 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 155864010349 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 155864010350 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 155864010351 DNA binding residues [nucleotide binding] 155864010352 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 155864010353 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 155864010354 Peptidase family M23; Region: Peptidase_M23; pfam01551 155864010355 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 155864010356 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 155864010357 S-adenosylmethionine binding site [chemical binding]; other site 155864010358 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 155864010359 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 155864010360 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 155864010361 Permutation of conserved domain; other site 155864010362 active site 155864010363 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 155864010364 homotrimer interaction site [polypeptide binding]; other site 155864010365 zinc binding site [ion binding]; other site 155864010366 CDP-binding sites; other site 155864010367 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 155864010368 substrate binding site; other site 155864010369 dimer interface; other site 155864010370 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 155864010371 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 155864010372 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 155864010373 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 155864010374 ligand-binding site [chemical binding]; other site 155864010375 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 155864010376 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 155864010377 CysD dimerization site [polypeptide binding]; other site 155864010378 G1 box; other site 155864010379 putative GEF interaction site [polypeptide binding]; other site 155864010380 GTP/Mg2+ binding site [chemical binding]; other site 155864010381 Switch I region; other site 155864010382 G2 box; other site 155864010383 G3 box; other site 155864010384 Switch II region; other site 155864010385 G4 box; other site 155864010386 G5 box; other site 155864010387 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 155864010388 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 155864010389 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 155864010390 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 155864010391 Active Sites [active] 155864010392 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 155864010393 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 155864010394 metal binding site [ion binding]; metal-binding site 155864010395 O-island #111; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864010396 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648 155864010397 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 155864010398 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09664 155864010399 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 155864010400 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 155864010401 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cd09646 155864010402 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09670 155864010403 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09669 155864010404 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 155864010405 CRISPR-associated helicase Cas3 [Defense mechanisms]; Region: COG1203 155864010406 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 155864010407 Hok/gef family; Region: HOK_GEF; pfam01848 155864010408 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 155864010409 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 155864010410 Active Sites [active] 155864010411 sulfite reductase subunit beta; Provisional; Region: PRK13504 155864010412 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 155864010413 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 155864010414 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 155864010415 Flavodoxin; Region: Flavodoxin_1; pfam00258 155864010416 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 155864010417 FAD binding pocket [chemical binding]; other site 155864010418 FAD binding motif [chemical binding]; other site 155864010419 catalytic residues [active] 155864010420 NAD binding pocket [chemical binding]; other site 155864010421 phosphate binding motif [ion binding]; other site 155864010422 beta-alpha-beta structure motif; other site 155864010423 6-pyruvoyl tetrahydropterin synthase (PTPS). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids, as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after uptake by a...; Region: PTPS; cd00470 155864010424 homohexamer interface [polypeptide binding]; other site 155864010425 putative substrate stabilizing pore; other site 155864010426 pterin binding site; other site 155864010427 putative oxidoreductase FixC; Provisional; Region: PRK10157 155864010428 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 155864010429 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 155864010430 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 155864010431 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 155864010432 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 155864010433 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 155864010434 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 155864010435 Ligand binding site [chemical binding]; other site 155864010436 Electron transfer flavoprotein domain; Region: ETF; pfam01012 155864010437 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 155864010438 benzoate transport; Region: 2A0115; TIGR00895 155864010439 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864010440 putative substrate translocation pore; other site 155864010441 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 155864010442 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 155864010443 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 155864010444 NADP binding site [chemical binding]; other site 155864010445 homodimer interface [polypeptide binding]; other site 155864010446 active site 155864010447 Major Facilitator Superfamily; Region: MFS_1; pfam07690 155864010448 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864010449 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 155864010450 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 155864010451 nucleotide binding site [chemical binding]; other site 155864010452 similar to hypothetical protein; No significant matches 155864010453 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 155864010454 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 155864010455 O-island #112; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864010456 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 155864010457 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 155864010458 Repair protein; Region: Repair_PSII; pfam04536 155864010459 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 155864010460 Repair protein; Region: Repair_PSII; pfam04536 155864010461 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 155864010462 Repair protein; Region: Repair_PSII; pfam04536 155864010463 O-island #113; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864010464 enolase; Provisional; Region: eno; PRK00077 155864010465 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 155864010466 dimer interface [polypeptide binding]; other site 155864010467 metal binding site [ion binding]; metal-binding site 155864010468 substrate binding pocket [chemical binding]; other site 155864010469 CTP synthetase; Validated; Region: pyrG; PRK05380 155864010470 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 155864010471 Catalytic site [active] 155864010472 active site 155864010473 UTP binding site [chemical binding]; other site 155864010474 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 155864010475 active site 155864010476 putative oxyanion hole; other site 155864010477 catalytic triad [active] 155864010478 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 155864010479 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 155864010480 homodimer interface [polypeptide binding]; other site 155864010481 metal binding site [ion binding]; metal-binding site 155864010482 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 155864010483 homodimer interface [polypeptide binding]; other site 155864010484 active site 155864010485 putative chemical substrate binding site [chemical binding]; other site 155864010486 metal binding site [ion binding]; metal-binding site 155864010487 toxin MazF; Provisional; Region: PRK09907 155864010488 antitoxin MazE; Provisional; Region: PRK09798 155864010489 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 155864010490 HD domain; Region: HD_4; pfam13328 155864010491 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 155864010492 synthetase active site [active] 155864010493 NTP binding site [chemical binding]; other site 155864010494 metal binding site [ion binding]; metal-binding site 155864010495 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 155864010496 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 155864010497 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 155864010498 TRAM domain; Region: TRAM; pfam01938 155864010499 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 155864010500 S-adenosylmethionine binding site [chemical binding]; other site 155864010501 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 155864010502 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 155864010503 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 155864010504 dimerization interface [polypeptide binding]; other site 155864010505 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 155864010506 dimer interface [polypeptide binding]; other site 155864010507 phosphorylation site [posttranslational modification] 155864010508 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 155864010509 ATP binding site [chemical binding]; other site 155864010510 Mg2+ binding site [ion binding]; other site 155864010511 G-X-G motif; other site 155864010512 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 155864010513 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 155864010514 active site 155864010515 phosphorylation site [posttranslational modification] 155864010516 intermolecular recognition site; other site 155864010517 dimerization interface [polypeptide binding]; other site 155864010518 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 155864010519 putative binding surface; other site 155864010520 active site 155864010521 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 155864010522 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 155864010523 active site 155864010524 tetramer interface [polypeptide binding]; other site 155864010525 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 155864010526 metal binding site [ion binding]; metal-binding site 155864010527 substrate binding pocket [chemical binding]; other site 155864010528 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 155864010529 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864010530 D-galactonate transporter; Region: 2A0114; TIGR00893 155864010531 putative substrate translocation pore; other site 155864010532 flavodoxin; Provisional; Region: PRK08105 155864010533 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 155864010534 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 155864010535 probable active site [active] 155864010536 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 155864010537 SecY interacting protein Syd; Provisional; Region: PRK04968 155864010538 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 155864010539 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 155864010540 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 155864010541 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 155864010542 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 155864010543 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 155864010544 serine transporter; Region: stp; TIGR00814 155864010545 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 155864010546 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 155864010547 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 155864010548 flap endonuclease-like protein; Provisional; Region: PRK09482 155864010549 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 155864010550 active site 155864010551 metal binding site 1 [ion binding]; metal-binding site 155864010552 putative 5' ssDNA interaction site; other site 155864010553 metal binding site 3; metal-binding site 155864010554 metal binding site 2 [ion binding]; metal-binding site 155864010555 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 155864010556 putative DNA binding site [nucleotide binding]; other site 155864010557 putative metal binding site [ion binding]; other site 155864010558 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 155864010559 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 155864010560 dimer interface [polypeptide binding]; other site 155864010561 active site 155864010562 metal binding site [ion binding]; metal-binding site 155864010563 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 155864010564 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 155864010565 intersubunit interface [polypeptide binding]; other site 155864010566 active site 155864010567 Zn2+ binding site [ion binding]; other site 155864010568 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 155864010569 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864010570 putative substrate translocation pore; other site 155864010571 L-fucose isomerase; Provisional; Region: fucI; PRK10991 155864010572 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 155864010573 hexamer (dimer of trimers) interface [polypeptide binding]; other site 155864010574 trimer interface [polypeptide binding]; other site 155864010575 substrate binding site [chemical binding]; other site 155864010576 Mn binding site [ion binding]; other site 155864010577 L-fuculokinase; Provisional; Region: PRK10331 155864010578 L-fuculose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_FK; cd07773 155864010579 putative N- and C-terminal domain interface [polypeptide binding]; other site 155864010580 putative active site [active] 155864010581 putative MgATP binding site [chemical binding]; other site 155864010582 putative catalytic site [active] 155864010583 metal binding site [ion binding]; metal-binding site 155864010584 putative carbohydrate binding site [chemical binding]; other site 155864010585 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 155864010586 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 155864010587 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 155864010588 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 155864010589 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 155864010590 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 155864010591 hypothetical protein; Provisional; Region: PRK10873 155864010592 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 155864010593 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 155864010594 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 155864010595 dimerization interface [polypeptide binding]; other site 155864010596 substrate binding pocket [chemical binding]; other site 155864010597 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 155864010598 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 155864010599 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 155864010600 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 155864010601 catalytic residue [active] 155864010602 CsdA-binding activator; Provisional; Region: PRK15019 155864010603 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 155864010604 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 155864010605 putative ATP binding site [chemical binding]; other site 155864010606 putative substrate interface [chemical binding]; other site 155864010607 murein transglycosylase A; Provisional; Region: mltA; PRK11162 155864010608 MltA specific insert domain; Region: MltA; pfam03562 155864010609 3D domain; Region: 3D; pfam06725 155864010610 AMIN domain; Region: AMIN; pfam11741 155864010611 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 155864010612 active site 155864010613 metal binding site [ion binding]; metal-binding site 155864010614 N-acetylglutamate synthase; Validated; Region: PRK05279 155864010615 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 155864010616 putative feedback inhibition sensing region; other site 155864010617 putative nucleotide binding site [chemical binding]; other site 155864010618 putative substrate binding site [chemical binding]; other site 155864010619 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 155864010620 Coenzyme A binding pocket [chemical binding]; other site 155864010621 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 155864010622 AAA domain; Region: AAA_30; pfam13604 155864010623 Family description; Region: UvrD_C_2; pfam13538 155864010624 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 155864010625 protease3; Provisional; Region: PRK15101 155864010626 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 155864010627 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 155864010628 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 155864010629 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 155864010630 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 155864010631 hypothetical protein; Provisional; Region: PRK10332 155864010632 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 155864010633 hypothetical protein; Provisional; Region: PRK11521 155864010634 hypothetical protein; Provisional; Region: PRK10557 155864010635 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 155864010636 hypothetical protein; Provisional; Region: PRK10506 155864010637 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 155864010638 thymidylate synthase; Reviewed; Region: thyA; PRK01827 155864010639 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 155864010640 dimerization interface [polypeptide binding]; other site 155864010641 active site 155864010642 prolipoprotein diacylglyceryl transferase; Region: lgt; TIGR00544 155864010643 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 155864010644 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 155864010645 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 155864010646 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 155864010647 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 155864010648 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 155864010649 putative active site [active] 155864010650 Ap4A binding site [chemical binding]; other site 155864010651 nudix motif; other site 155864010652 putative metal binding site [ion binding]; other site 155864010653 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 155864010654 putative DNA-binding cleft [nucleotide binding]; other site 155864010655 putative DNA clevage site; other site 155864010656 molecular lever; other site 155864010657 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 155864010658 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 155864010659 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 155864010660 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 155864010661 active site 155864010662 catalytic tetrad [active] 155864010663 lysophospholipid transporter LplT; Provisional; Region: PRK11195 155864010664 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864010665 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 155864010666 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 155864010667 putative acyl-acceptor binding pocket; other site 155864010668 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 155864010669 acyl-activating enzyme (AAE) consensus motif; other site 155864010670 putative AMP binding site [chemical binding]; other site 155864010671 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 155864010672 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 155864010673 DNA binding site [nucleotide binding] 155864010674 domain linker motif; other site 155864010675 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 155864010676 dimerization interface (closed form) [polypeptide binding]; other site 155864010677 ligand binding site [chemical binding]; other site 155864010678 diaminopimelate decarboxylase; Provisional; Region: PRK11165 155864010679 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 155864010680 active site 155864010681 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 155864010682 substrate binding site [chemical binding]; other site 155864010683 catalytic residues [active] 155864010684 dimer interface [polypeptide binding]; other site 155864010685 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 155864010686 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 155864010687 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 155864010688 dimerization interface [polypeptide binding]; other site 155864010689 putative racemase; Provisional; Region: PRK10200 155864010690 aspartate racemase; Region: asp_race; TIGR00035 155864010691 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 155864010692 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864010693 putative substrate translocation pore; other site 155864010694 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864010695 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 155864010696 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 155864010697 NADP binding site [chemical binding]; other site 155864010698 homodimer interface [polypeptide binding]; other site 155864010699 active site 155864010700 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 155864010701 putative acyltransferase; Provisional; Region: PRK05790 155864010702 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 155864010703 dimer interface [polypeptide binding]; other site 155864010704 active site 155864010705 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 155864010706 serine transporter; Region: stp; TIGR00814 155864010707 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 155864010708 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 155864010709 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 155864010710 hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264 155864010711 O-island #114; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864010712 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 155864010713 Tetratricopeptide repeat; Region: TPR_3; pfam07720 155864010714 Tetratricopeptide repeat; Region: TPR_3; pfam07720 155864010715 transcriptional regulator; Provisional; Region: PRK11906 155864010716 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 155864010717 DNA binding site [nucleotide binding] 155864010718 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 155864010719 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 155864010720 N-acetyl-D-glucosamine binding site [chemical binding]; other site 155864010721 catalytic residue [active] 155864010722 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 155864010723 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 155864010724 DNA binding residues [nucleotide binding] 155864010725 dimerization interface [polypeptide binding]; other site 155864010726 invasion protein OrgB; Provisional; Region: PRK15322 155864010727 O-island #115; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864010728 Type III secretory pathway, lipoprotein EscJ [Intracellular trafficking and secretion]; Region: EscJ; COG4669 155864010729 type III secretion system needle complex protein PrgJ; Provisional; Region: PRK15325 155864010730 type III secretion system needle complex protein PrgH; Provisional; Region: PRK15327; cl12363 155864010731 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 155864010732 DNA binding residues [nucleotide binding] 155864010733 dimerization interface [polypeptide binding]; other site 155864010734 type III secretion system protein SpaS; Validated; Region: PRK08156 155864010735 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 155864010736 O-island #115; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864010737 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 155864010738 type III secretion system protein SpaQ; Provisional; Region: PRK15333 155864010739 type III secretion system protein SpaP; Provisional; Region: spaP; PRK12796 155864010740 type III secretion system protein SpaO; Validated; Region: PRK08158 155864010741 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 155864010742 Surface presentation of antigens protein; Region: SPAN; pfam02510 155864010743 Salmonella surface presentation of antigen gene type M protein; Region: SPAM; cl03442 155864010744 ATP synthase SpaL; Validated; Region: PRK08149 155864010745 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 155864010746 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 155864010747 Walker A motif; other site 155864010748 ATP binding site [chemical binding]; other site 155864010749 Walker B motif; other site 155864010750 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 155864010751 type III secretion system protein InvA; Provisional; Region: PRK15337 155864010752 type III secretion system regulator InvE; Provisional; Region: PRK15338 155864010753 HrpJ-like domain; Region: HrpJ; pfam07201 155864010754 type III secretion system outer membrane pore InvG; Provisional; Region: PRK15339 155864010755 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 155864010756 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 155864010757 transcriptional regulator InvF; Provisional; Region: PRK15340 155864010758 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 155864010759 O-island #115; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864010760 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 155864010761 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 155864010762 O-island #116; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864010763 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 155864010764 Peptidase family M23; Region: Peptidase_M23; pfam01551 155864010765 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 155864010766 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 155864010767 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 155864010768 xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971 155864010769 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 155864010770 xanthine dehydrogenase subunit XdhC; Provisional; Region: PRK09908 155864010771 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 155864010772 catalytic loop [active] 155864010773 iron binding site [ion binding]; other site 155864010774 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 155864010775 GAF domain; Region: GAF; cl17456 155864010776 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 155864010777 PAS domain; Region: PAS; smart00091 155864010778 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 155864010779 Walker A motif; other site 155864010780 ATP binding site [chemical binding]; other site 155864010781 Walker B motif; other site 155864010782 arginine finger; other site 155864010783 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 155864010784 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 155864010785 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 155864010786 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 155864010787 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 155864010788 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 155864010789 catalytic residue [active] 155864010790 peptidase; Reviewed; Region: PRK13004 155864010791 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 155864010792 putative metal binding site [ion binding]; other site 155864010793 putative dimer interface [polypeptide binding]; other site 155864010794 D-hydantoinase; Region: D-hydantoinase; TIGR02033 155864010795 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 155864010796 tetramer interface [polypeptide binding]; other site 155864010797 active site 155864010798 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 155864010799 carbamate kinase; Reviewed; Region: PRK12686 155864010800 putative substrate binding site [chemical binding]; other site 155864010801 homodimer interface [polypeptide binding]; other site 155864010802 nucleotide binding site [chemical binding]; other site 155864010803 nucleotide binding site [chemical binding]; other site 155864010804 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 155864010805 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 155864010806 XdhC Rossmann domain; Region: XdhC_C; pfam13478 155864010807 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 155864010808 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 155864010809 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 155864010810 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 155864010811 Ligand binding site; other site 155864010812 metal-binding site 155864010813 putative selenate reductase subunit YgfK; Provisional; Region: PRK09853 155864010814 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 155864010815 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 155864010816 putative selenium metabolism protein SsnA; Region: Se_ssnA; TIGR03314 155864010817 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 155864010818 active site 155864010819 putative substrate binding pocket [chemical binding]; other site 155864010820 probable selenate reductase, FAD-binding subunit; Region: Se_sel_red_FAD; TIGR03312 155864010821 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 155864010822 putative hypoxanthine oxidase; Provisional; Region: PRK09800 155864010823 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 155864010824 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 155864010825 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 155864010826 uracil-xanthine permease; Region: ncs2; TIGR00801 155864010827 guanine deaminase; Provisional; Region: PRK09228 155864010828 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 155864010829 active site 155864010830 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 155864010831 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 155864010832 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12809 155864010833 4Fe-4S binding domain; Region: Fer4; pfam00037 155864010834 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 155864010835 xanthine permease; Region: pbuX; TIGR03173 155864010836 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 155864010837 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 155864010838 active site 155864010839 metal binding site [ion binding]; metal-binding site 155864010840 nudix motif; other site 155864010841 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 155864010842 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 155864010843 dimer interface [polypeptide binding]; other site 155864010844 putative anticodon binding site; other site 155864010845 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 155864010846 motif 1; other site 155864010847 active site 155864010848 motif 2; other site 155864010849 motif 3; other site 155864010850 peptide chain release factor 2; Validated; Region: prfB; PRK00578 155864010851 This domain is found in peptide chain release factors; Region: PCRF; smart00937 155864010852 RF-1 domain; Region: RF-1; pfam00472 155864010853 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 155864010854 DHH family; Region: DHH; pfam01368 155864010855 DHHA1 domain; Region: DHHA1; pfam02272 155864010856 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 155864010857 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 155864010858 dimerization domain [polypeptide binding]; other site 155864010859 dimer interface [polypeptide binding]; other site 155864010860 catalytic residues [active] 155864010861 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 155864010862 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 155864010863 active site 155864010864 Int/Topo IB signature motif; other site 155864010865 flavodoxin FldB; Provisional; Region: PRK12359 155864010866 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 155864010867 hypothetical protein; Provisional; Region: PRK10878 155864010868 putative global regulator; Reviewed; Region: PRK09559 155864010869 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 155864010870 hemolysin; Provisional; Region: PRK15087 155864010871 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 155864010872 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 155864010873 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 155864010874 beta-galactosidase; Region: BGL; TIGR03356 155864010875 O-island #117; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864010876 glycine dehydrogenase; Provisional; Region: PRK05367 155864010877 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 155864010878 tetramer interface [polypeptide binding]; other site 155864010879 pyridoxal 5'-phosphate binding site [chemical binding]; other site 155864010880 catalytic residue [active] 155864010881 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 155864010882 tetramer interface [polypeptide binding]; other site 155864010883 pyridoxal 5'-phosphate binding site [chemical binding]; other site 155864010884 catalytic residue [active] 155864010885 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 155864010886 lipoyl attachment site [posttranslational modification]; other site 155864010887 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 155864010888 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 155864010889 oxidoreductase; Provisional; Region: PRK08013 155864010890 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 155864010891 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 155864010892 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 155864010893 proline aminopeptidase P II; Provisional; Region: PRK10879 155864010894 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 155864010895 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 155864010896 active site 155864010897 hypothetical protein; Reviewed; Region: PRK01736 155864010898 Z-ring-associated protein; Provisional; Region: PRK10972 155864010899 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 155864010900 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 155864010901 O-island #118; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864010902 similar to hypothetical protein; No significant matches 155864010903 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 155864010904 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 155864010905 ligand binding site [chemical binding]; other site 155864010906 NAD binding site [chemical binding]; other site 155864010907 tetramer interface [polypeptide binding]; other site 155864010908 catalytic site [active] 155864010909 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 155864010910 L-serine binding site [chemical binding]; other site 155864010911 ACT domain interface; other site 155864010912 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 155864010913 tetramer (dimer of dimers) interface [polypeptide binding]; other site 155864010914 active site 155864010915 dimer interface [polypeptide binding]; other site 155864010916 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 155864010917 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 155864010918 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 155864010919 putative dimerization interface [polypeptide binding]; other site 155864010920 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 155864010921 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 155864010922 active site 155864010923 substrate binding site [chemical binding]; other site 155864010924 coenzyme B12 binding site [chemical binding]; other site 155864010925 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 155864010926 B12 binding site [chemical binding]; other site 155864010927 cobalt ligand [ion binding]; other site 155864010928 membrane ATPase/protein kinase; Provisional; Region: PRK09435 155864010929 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 155864010930 Walker A; other site 155864010931 methylmalonyl-CoA decarboxylase; Provisional; Region: PRK11423 155864010932 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 155864010933 substrate binding site [chemical binding]; other site 155864010934 oxyanion hole (OAH) forming residues; other site 155864010935 trimer interface [polypeptide binding]; other site 155864010936 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 155864010937 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 155864010938 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 155864010939 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 155864010940 Transcriptional regulator [Transcription]; Region: LysR; COG0583 155864010941 Uncharacterized conserved protein [Function unknown]; Region: COG2968 155864010942 oxidative stress defense protein; Provisional; Region: PRK11087 155864010943 arginine exporter protein; Provisional; Region: PRK09304 155864010944 mechanosensitive channel MscS; Provisional; Region: PRK10334 155864010945 Mechanosensitive ion channel; Region: MS_channel; pfam00924 155864010946 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 155864010947 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 155864010948 active site 155864010949 intersubunit interface [polypeptide binding]; other site 155864010950 zinc binding site [ion binding]; other site 155864010951 Na+ binding site [ion binding]; other site 155864010952 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 155864010953 Phosphoglycerate kinase; Region: PGK; pfam00162 155864010954 substrate binding site [chemical binding]; other site 155864010955 hinge regions; other site 155864010956 ADP binding site [chemical binding]; other site 155864010957 catalytic site [active] 155864010958 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 155864010959 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 155864010960 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 155864010961 O-island #119; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864010962 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 155864010963 trimer interface [polypeptide binding]; other site 155864010964 putative Zn binding site [ion binding]; other site 155864010965 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 155864010966 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 155864010967 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 155864010968 Walker A/P-loop; other site 155864010969 ATP binding site [chemical binding]; other site 155864010970 Q-loop/lid; other site 155864010971 ABC transporter signature motif; other site 155864010972 Walker B; other site 155864010973 D-loop; other site 155864010974 H-loop/switch region; other site 155864010975 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 155864010976 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 155864010977 Walker A/P-loop; other site 155864010978 ATP binding site [chemical binding]; other site 155864010979 Q-loop/lid; other site 155864010980 ABC transporter signature motif; other site 155864010981 Walker B; other site 155864010982 D-loop; other site 155864010983 H-loop/switch region; other site 155864010984 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 155864010985 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 155864010986 active site 155864010987 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 155864010988 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10022 155864010989 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 155864010990 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 155864010991 putative active site [active] 155864010992 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 155864010993 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 155864010994 putative NAD(P) binding site [chemical binding]; other site 155864010995 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 155864010996 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 155864010997 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 155864010998 active site 155864010999 P-loop; other site 155864011000 phosphorylation site [posttranslational modification] 155864011001 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 155864011002 active site 155864011003 phosphorylation site [posttranslational modification] 155864011004 transketolase; Reviewed; Region: PRK12753 155864011005 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 155864011006 TPP-binding site [chemical binding]; other site 155864011007 dimer interface [polypeptide binding]; other site 155864011008 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 155864011009 PYR/PP interface [polypeptide binding]; other site 155864011010 dimer interface [polypeptide binding]; other site 155864011011 TPP binding site [chemical binding]; other site 155864011012 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 155864011013 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 155864011014 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 155864011015 agmatinase; Region: agmatinase; TIGR01230 155864011016 oligomer interface [polypeptide binding]; other site 155864011017 putative active site [active] 155864011018 Mn binding site [ion binding]; other site 155864011019 O-island #120; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864011020 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 155864011021 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 155864011022 dimer interface [polypeptide binding]; other site 155864011023 active site 155864011024 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 155864011025 catalytic residues [active] 155864011026 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 155864011027 Virulence promoting factor; Region: YqgB; pfam11036 155864011028 Protein of unknown function (DUF2684); Region: DUF2684; pfam10885 155864011029 S-adenosylmethionine synthetase; Validated; Region: PRK05250 155864011030 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 155864011031 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 155864011032 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 155864011033 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 155864011034 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864011035 putative substrate translocation pore; other site 155864011036 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864011037 hypothetical protein; Provisional; Region: PRK04860 155864011038 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 155864011039 DNA-specific endonuclease I; Provisional; Region: PRK15137 155864011040 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 155864011041 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 155864011042 RNA methyltransferase, RsmE family; Region: TIGR00046 155864011043 glutathione synthetase; Provisional; Region: PRK05246 155864011044 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 155864011045 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 155864011046 hypothetical protein; Validated; Region: PRK00228 155864011047 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 155864011048 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 155864011049 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 155864011050 Walker A motif; other site 155864011051 ATP binding site [chemical binding]; other site 155864011052 Walker B motif; other site 155864011053 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 155864011054 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 155864011055 catalytic residue [active] 155864011056 YGGT family; Region: YGGT; pfam02325 155864011057 YGGT family; Region: YGGT; pfam02325 155864011058 hypothetical protein; Validated; Region: PRK05090 155864011059 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 155864011060 active site 155864011061 dimerization interface [polypeptide binding]; other site 155864011062 HemN family oxidoreductase; Provisional; Region: PRK05660 155864011063 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 155864011064 FeS/SAM binding site; other site 155864011065 HemN C-terminal domain; Region: HemN_C; pfam06969 155864011066 O-island #121; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864011067 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 155864011068 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 155864011069 homodimer interface [polypeptide binding]; other site 155864011070 active site 155864011071 hypothetical protein; Provisional; Region: PRK10626 155864011072 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 155864011073 hypothetical protein; Provisional; Region: PRK11702 155864011074 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 155864011075 adenine DNA glycosylase; Provisional; Region: PRK10880 155864011076 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 155864011077 minor groove reading motif; other site 155864011078 helix-hairpin-helix signature motif; other site 155864011079 substrate binding pocket [chemical binding]; other site 155864011080 active site 155864011081 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 155864011082 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 155864011083 DNA binding and oxoG recognition site [nucleotide binding] 155864011084 oxidative damage protection protein; Provisional; Region: PRK05408 155864011085 murein transglycosylase C; Provisional; Region: mltC; PRK11671 155864011086 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 155864011087 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 155864011088 N-acetyl-D-glucosamine binding site [chemical binding]; other site 155864011089 catalytic residue [active] 155864011090 nucleoside transporter; Region: 2A0110; TIGR00889 155864011091 ornithine decarboxylase; Provisional; Region: PRK13578 155864011092 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 155864011093 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 155864011094 homodimer interface [polypeptide binding]; other site 155864011095 pyridoxal 5'-phosphate binding site [chemical binding]; other site 155864011096 catalytic residue [active] 155864011097 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 155864011098 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 155864011099 O-island #122; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864011100 integrase; Provisional; Region: PRK09692 155864011101 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 155864011102 active site 155864011103 Int/Topo IB signature motif; other site 155864011104 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 155864011105 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 155864011106 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 155864011107 Homeodomain-like domain; Region: HTH_23; pfam13384 155864011108 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 155864011109 Transposase; Region: HTH_Tnp_1; pfam01527 155864011110 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 155864011111 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 155864011112 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 155864011113 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 155864011114 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 155864011115 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 155864011116 Nuclease-related domain; Region: NERD; pfam08378 155864011117 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 155864011118 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 155864011119 Integrase core domain; Region: rve_3; cl15866 155864011120 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 155864011121 O-island #122; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864011122 non-LEE encoded effector protein NleB; Provisional; Region: PRK15382 155864011123 type III secretion system protein; Provisional; Region: PRK15384; cl14665 155864011124 Homeodomain-like domain; Region: HTH_23; pfam13384 155864011125 Winged helix-turn helix; Region: HTH_29; pfam13551 155864011126 Homeodomain-like domain; Region: HTH_32; pfam13565 155864011127 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 155864011128 DDE superfamily endonuclease; Region: DDE_3; pfam13358 155864011129 TcdB toxin N-terminal helical domain; Region: TcdB_N; pfam12918 155864011130 TcdA/TcdB catalytic glycosyltransferase domain; Region: TcdA_TcdB; pfam12919 155864011131 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 155864011132 Integrase core domain; Region: rve; pfam00665 155864011133 Integrase core domain; Region: rve_3; pfam13683 155864011134 Transposase; Region: HTH_Tnp_1; cl17663 155864011135 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 155864011136 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 155864011137 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 155864011138 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 155864011139 homodimer interface [polypeptide binding]; other site 155864011140 putative GKAP docking site [polypeptide binding]; other site 155864011141 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 155864011142 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 155864011143 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 155864011144 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 155864011145 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 155864011146 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 155864011147 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 155864011148 O-island #122; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864011149 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 155864011150 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 155864011151 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 155864011152 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 155864011153 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 155864011154 Phosphate transporter family; Region: PHO4; cl00396 155864011155 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 155864011156 CHAP domain; Region: CHAP; pfam05257 155864011157 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 155864011158 putative S-transferase; Provisional; Region: PRK11752 155864011159 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 155864011160 C-terminal domain interface [polypeptide binding]; other site 155864011161 GSH binding site (G-site) [chemical binding]; other site 155864011162 dimer interface [polypeptide binding]; other site 155864011163 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 155864011164 dimer interface [polypeptide binding]; other site 155864011165 N-terminal domain interface [polypeptide binding]; other site 155864011166 active site 155864011167 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 155864011168 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 155864011169 hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380 155864011170 hydrogenase 2-specific chaperone; Provisional; Region: PRK10465 155864011171 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 155864011172 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 155864011173 putative substrate-binding site; other site 155864011174 nickel binding site [ion binding]; other site 155864011175 hydrogenase 2 large subunit; Provisional; Region: PRK10467 155864011176 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 155864011177 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 155864011178 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 155864011179 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 155864011180 4Fe-4S binding domain; Region: Fer4_6; pfam12837 155864011181 hydrogenase 2 small subunit; Provisional; Region: PRK10468 155864011182 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 155864011183 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 155864011184 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 155864011185 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 155864011186 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 155864011187 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 155864011188 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 155864011189 active site 155864011190 catalytic tetrad [active] 155864011191 hypothetical protein; Provisional; Region: PRK05208 155864011192 oxidoreductase; Provisional; Region: PRK07985 155864011193 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 155864011194 NAD binding site [chemical binding]; other site 155864011195 metal binding site [ion binding]; metal-binding site 155864011196 active site 155864011197 biopolymer transport protein ExbD; Provisional; Region: PRK11267 155864011198 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 155864011199 biopolymer transport protein ExbB; Provisional; Region: PRK10414 155864011200 cystathionine beta-lyase; Provisional; Region: PRK08114 155864011201 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 155864011202 homodimer interface [polypeptide binding]; other site 155864011203 substrate-cofactor binding pocket; other site 155864011204 pyridoxal 5'-phosphate binding site [chemical binding]; other site 155864011205 catalytic residue [active] 155864011206 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 155864011207 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 155864011208 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 155864011209 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 155864011210 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 155864011211 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 155864011212 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 155864011213 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 155864011214 dimer interface [polypeptide binding]; other site 155864011215 active site 155864011216 metal binding site [ion binding]; metal-binding site 155864011217 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 155864011218 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 155864011219 active site 155864011220 catalytic tetrad [active] 155864011221 putative outer membrane lipoprotein; Provisional; Region: PRK09973 155864011222 hypothetical protein; Provisional; Region: PRK01254 155864011223 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 155864011224 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 155864011225 FtsI repressor; Provisional; Region: PRK10883 155864011226 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 155864011227 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 155864011228 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 155864011229 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 155864011230 putative acyl-acceptor binding pocket; other site 155864011231 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 155864011232 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 155864011233 CAP-like domain; other site 155864011234 active site 155864011235 primary dimer interface [polypeptide binding]; other site 155864011236 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 155864011237 putative ABC transporter periplasmic-binding protein; Provisional; Region: PRK09755 155864011238 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 155864011239 peptide binding site [polypeptide binding]; other site 155864011240 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 155864011241 TIGR00156 family protein; Region: TIGR00156 155864011242 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 155864011243 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 155864011244 active site 155864011245 phosphorylation site [posttranslational modification] 155864011246 intermolecular recognition site; other site 155864011247 dimerization interface [polypeptide binding]; other site 155864011248 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 155864011249 DNA binding site [nucleotide binding] 155864011250 sensor protein QseC; Provisional; Region: PRK10337 155864011251 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 155864011252 dimer interface [polypeptide binding]; other site 155864011253 phosphorylation site [posttranslational modification] 155864011254 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 155864011255 ATP binding site [chemical binding]; other site 155864011256 Mg2+ binding site [ion binding]; other site 155864011257 G-X-G motif; other site 155864011258 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 155864011259 Uncharacterized conserved protein [Function unknown]; Region: COG1359 155864011260 O-island #123; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864011261 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 155864011262 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 155864011263 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cd04795 155864011264 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 155864011265 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 155864011266 siderophore binding site; other site 155864011267 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 155864011268 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 155864011269 ABC-ATPase subunit interface; other site 155864011270 dimer interface [polypeptide binding]; other site 155864011271 putative PBP binding regions; other site 155864011272 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 155864011273 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 155864011274 dimer interface [polypeptide binding]; other site 155864011275 putative PBP binding regions; other site 155864011276 ABC-ATPase subunit interface; other site 155864011277 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 155864011278 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 155864011279 Walker A/P-loop; other site 155864011280 ATP binding site [chemical binding]; other site 155864011281 Q-loop/lid; other site 155864011282 ABC transporter signature motif; other site 155864011283 Walker B; other site 155864011284 D-loop; other site 155864011285 H-loop/switch region; other site 155864011286 O-island #123; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864011287 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 155864011288 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 155864011289 N-terminal plug; other site 155864011290 ligand-binding site [chemical binding]; other site 155864011291 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 155864011292 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 155864011293 ATP binding site [chemical binding]; other site 155864011294 Mg2+ binding site [ion binding]; other site 155864011295 G-X-G motif; other site 155864011296 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 155864011297 anchoring element; other site 155864011298 dimer interface [polypeptide binding]; other site 155864011299 ATP binding site [chemical binding]; other site 155864011300 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 155864011301 active site 155864011302 metal binding site [ion binding]; metal-binding site 155864011303 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 155864011304 esterase YqiA; Provisional; Region: PRK11071 155864011305 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 155864011306 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 155864011307 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 155864011308 active site 155864011309 metal binding site [ion binding]; metal-binding site 155864011310 hexamer interface [polypeptide binding]; other site 155864011311 putative dehydrogenase; Provisional; Region: PRK11039 155864011312 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 155864011313 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 155864011314 dimer interface [polypeptide binding]; other site 155864011315 ADP-ribose binding site [chemical binding]; other site 155864011316 active site 155864011317 nudix motif; other site 155864011318 metal binding site [ion binding]; metal-binding site 155864011319 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 155864011320 hypothetical protein; Provisional; Region: PRK11653 155864011321 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 155864011322 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 155864011323 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 155864011324 putative active site [active] 155864011325 metal binding site [ion binding]; metal-binding site 155864011326 zinc transporter ZupT; Provisional; Region: PRK04201 155864011327 ZIP Zinc transporter; Region: Zip; pfam02535 155864011328 Protein of unknown function (DUF4051); Region: DUF4051; pfam13260 155864011329 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 155864011330 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 155864011331 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 155864011332 O-island #124; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864011333 glycogen synthesis protein GlgS; Provisional; Region: PRK02922 155864011334 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 155864011335 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 155864011336 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 155864011337 O-island #125; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864011338 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 155864011339 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 155864011340 putative ribose interaction site [chemical binding]; other site 155864011341 putative ADP binding site [chemical binding]; other site 155864011342 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 155864011343 active site 155864011344 nucleotide binding site [chemical binding]; other site 155864011345 HIGH motif; other site 155864011346 KMSKS motif; other site 155864011347 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 155864011348 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 155864011349 metal binding triad; other site 155864011350 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 155864011351 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 155864011352 metal binding triad; other site 155864011353 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 155864011354 Uncharacterized conserved protein [Function unknown]; Region: COG3025 155864011355 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 155864011356 putative active site [active] 155864011357 putative metal binding residues [ion binding]; other site 155864011358 signature motif; other site 155864011359 putative triphosphate binding site [ion binding]; other site 155864011360 CHAD domain; Region: CHAD; pfam05235 155864011361 SH3 domain-containing protein; Provisional; Region: PRK10884 155864011362 Bacterial SH3 domain homologues; Region: SH3b; smart00287 155864011363 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 155864011364 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 155864011365 active site 155864011366 NTP binding site [chemical binding]; other site 155864011367 metal binding triad [ion binding]; metal-binding site 155864011368 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 155864011369 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 155864011370 Zn2+ binding site [ion binding]; other site 155864011371 Mg2+ binding site [ion binding]; other site 155864011372 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 155864011373 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 155864011374 homooctamer interface [polypeptide binding]; other site 155864011375 active site 155864011376 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 155864011377 transcriptional activator TtdR; Provisional; Region: PRK09801 155864011378 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 155864011379 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 155864011380 putative effector binding pocket; other site 155864011381 putative dimerization interface [polypeptide binding]; other site 155864011382 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 155864011383 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 155864011384 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 155864011385 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 155864011386 transmembrane helices; other site 155864011387 UGMP family protein; Validated; Region: PRK09604 155864011388 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 155864011389 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 155864011390 DNA primase; Validated; Region: dnaG; PRK05667 155864011391 CHC2 zinc finger; Region: zf-CHC2; pfam01807 155864011392 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 155864011393 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 155864011394 active site 155864011395 metal binding site [ion binding]; metal-binding site 155864011396 interdomain interaction site; other site 155864011397 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 155864011398 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 155864011399 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 155864011400 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 155864011401 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 155864011402 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 155864011403 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 155864011404 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 155864011405 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 155864011406 DNA binding residues [nucleotide binding] 155864011407 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 155864011408 active site 155864011409 SUMO-1 interface [polypeptide binding]; other site 155864011410 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 155864011411 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 155864011412 FAD binding pocket [chemical binding]; other site 155864011413 FAD binding motif [chemical binding]; other site 155864011414 phosphate binding motif [ion binding]; other site 155864011415 NAD binding pocket [chemical binding]; other site 155864011416 Predicted transcriptional regulators [Transcription]; Region: COG1695 155864011417 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 155864011418 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 155864011419 PAS fold; Region: PAS_3; pfam08447 155864011420 putative active site [active] 155864011421 heme pocket [chemical binding]; other site 155864011422 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 155864011423 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 155864011424 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 155864011425 dimer interface [polypeptide binding]; other site 155864011426 putative CheW interface [polypeptide binding]; other site 155864011427 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 155864011428 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 155864011429 inhibitor-cofactor binding pocket; inhibition site 155864011430 pyridoxal 5'-phosphate binding site [chemical binding]; other site 155864011431 catalytic residue [active] 155864011432 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 155864011433 dimer interface [polypeptide binding]; other site 155864011434 putative tRNA-binding site [nucleotide binding]; other site 155864011435 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 155864011436 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 155864011437 DNA binding site [nucleotide binding] 155864011438 domain linker motif; other site 155864011439 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 155864011440 putative dimerization interface [polypeptide binding]; other site 155864011441 putative ligand binding site [chemical binding]; other site 155864011442 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 155864011443 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 155864011444 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 155864011445 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 155864011446 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 155864011447 cryptic beta-D-galactosidase subunit beta; Reviewed; Region: ebgC; PRK10202 155864011448 inner membrane transporter YjeM; Provisional; Region: PRK15238 155864011449 alpha-glucosidase; Provisional; Region: PRK10137 155864011450 Protein of unknown function, DUF608; Region: DUF608; pfam04685 155864011451 Trehalase; Region: Trehalase; cl17346 155864011452 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 155864011453 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 155864011454 active site 155864011455 FMN binding site [chemical binding]; other site 155864011456 2,4-decadienoyl-CoA binding site; other site 155864011457 catalytic residue [active] 155864011458 4Fe-4S cluster binding site [ion binding]; other site 155864011459 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 155864011460 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 155864011461 non-specific DNA binding site [nucleotide binding]; other site 155864011462 salt bridge; other site 155864011463 sequence-specific DNA binding site [nucleotide binding]; other site 155864011464 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4680 155864011465 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 155864011466 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 155864011467 S-adenosylmethionine binding site [chemical binding]; other site 155864011468 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 155864011469 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 155864011470 putative active site [active] 155864011471 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 155864011472 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 155864011473 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 155864011474 serine/threonine transporter SstT; Provisional; Region: PRK13628 155864011475 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 155864011476 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 155864011477 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 155864011478 galactarate dehydratase; Region: galactar-dH20; TIGR03248 155864011479 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 155864011480 Glucuronate isomerase; Region: UxaC; pfam02614 155864011481 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 155864011482 D-galactonate transporter; Region: 2A0114; TIGR00893 155864011483 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864011484 putative substrate translocation pore; other site 155864011485 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 155864011486 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 155864011487 DNA-binding site [nucleotide binding]; DNA binding site 155864011488 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 155864011489 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 155864011490 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 155864011491 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 155864011492 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 155864011493 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 155864011494 Predicted membrane protein [Function unknown]; Region: COG5393 155864011495 YqjK-like protein; Region: YqjK; pfam13997 155864011496 Predicted membrane protein [Function unknown]; Region: COG2259 155864011497 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 155864011498 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 155864011499 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 155864011500 putative dimer interface [polypeptide binding]; other site 155864011501 N-terminal domain interface [polypeptide binding]; other site 155864011502 putative substrate binding pocket (H-site) [chemical binding]; other site 155864011503 Predicted membrane protein [Function unknown]; Region: COG3152 155864011504 Predicted membrane protein [Function unknown]; Region: COG3152 155864011505 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 155864011506 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 155864011507 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 155864011508 dimerization interface [polypeptide binding]; other site 155864011509 Pirin-related protein [General function prediction only]; Region: COG1741 155864011510 Pirin; Region: Pirin; pfam02678 155864011511 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 155864011512 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 155864011513 serine transporter; Region: stp; TIGR00814 155864011514 L-serine dehydratase TdcG; Provisional; Region: PRK15040 155864011515 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 155864011516 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 155864011517 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 155864011518 homotrimer interaction site [polypeptide binding]; other site 155864011519 putative active site [active] 155864011520 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 155864011521 Pyruvate formate lyase 1; Region: PFL1; cd01678 155864011522 coenzyme A binding site [chemical binding]; other site 155864011523 active site 155864011524 catalytic residues [active] 155864011525 glycine loop; other site 155864011526 propionate/acetate kinase; Provisional; Region: PRK12379 155864011527 Acetokinase family; Region: Acetate_kinase; cl17229 155864011528 threonine/serine transporter TdcC; Provisional; Region: PRK13629 155864011529 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 155864011530 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 155864011531 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 155864011532 tetramer interface [polypeptide binding]; other site 155864011533 pyridoxal 5'-phosphate binding site [chemical binding]; other site 155864011534 catalytic residue [active] 155864011535 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 155864011536 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 155864011537 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 155864011538 putative substrate binding pocket [chemical binding]; other site 155864011539 putative dimerization interface [polypeptide binding]; other site 155864011540 DNA-binding transcriptional activator TdcR; Provisional; Region: PRK11424 155864011541 hypothetical protein; Provisional; Region: PRK09716 155864011542 glycerate kinase I; Provisional; Region: PRK10342 155864011543 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 155864011544 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 155864011545 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 155864011546 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864011547 D-galactonate transporter; Region: 2A0114; TIGR00893 155864011548 putative substrate translocation pore; other site 155864011549 galactarate dehydratase; Region: galactar-dH20; TIGR03248 155864011550 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 155864011551 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 155864011552 putative regulator PrlF; Provisional; Region: PRK09974 155864011553 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 155864011554 Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663 155864011555 DNA-binding transcriptional regulator AgaR; Provisional; Region: PRK09802 155864011556 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 155864011557 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 155864011558 tagatose 6-phosphate aldolase subunit KbaZ; Provisional; Region: PRK15458 155864011559 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 155864011560 active site 155864011561 phosphorylation site [posttranslational modification] 155864011562 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 155864011563 O-island #126; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864011564 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 155864011565 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 155864011566 active pocket/dimerization site; other site 155864011567 active site 155864011568 phosphorylation site [posttranslational modification] 155864011569 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 155864011570 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 155864011571 active site 155864011572 dimer interface [polypeptide binding]; other site 155864011573 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 155864011574 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 155864011575 dimer interface [polypeptide binding]; other site 155864011576 active site 155864011577 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 155864011578 putative active site [active] 155864011579 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cd00453 155864011580 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 155864011581 active site 155864011582 intersubunit interface [polypeptide binding]; other site 155864011583 zinc binding site [ion binding]; other site 155864011584 Na+ binding site [ion binding]; other site 155864011585 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 155864011586 active site 155864011587 phosphorylation site [posttranslational modification] 155864011588 PTS system N-acetylgalactosamine-specific transporter subunit IIC; Provisional; Region: PRK09757 155864011589 PTS system N-acetylgalactosamine-specific transporter subunit IID; Provisional; Region: PRK09855 155864011590 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 155864011591 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 155864011592 active site 155864011593 trimer interface [polypeptide binding]; other site 155864011594 allosteric site; other site 155864011595 active site lid [active] 155864011596 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 155864011597 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 155864011598 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 155864011599 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 155864011600 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 155864011601 PapC N-terminal domain; Region: PapC_N; pfam13954 155864011602 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 155864011603 PapC C-terminal domain; Region: PapC_C; pfam13953 155864011604 O-island #127; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864011605 Transposase; Region: HTH_Tnp_1; cl17663 155864011606 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 155864011607 Integrase core domain; Region: rve; pfam00665 155864011608 Integrase core domain; Region: rve_3; pfam13683 155864011609 Fimbrial protein; Region: Fimbrial; pfam00419 155864011610 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 155864011611 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 155864011612 putative SAM binding site [chemical binding]; other site 155864011613 putative homodimer interface [polypeptide binding]; other site 155864011614 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 155864011615 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 155864011616 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 155864011617 putative ligand binding site [chemical binding]; other site 155864011618 TIGR00252 family protein; Region: TIGR00252 155864011619 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 155864011620 dimer interface [polypeptide binding]; other site 155864011621 active site 155864011622 outer membrane lipoprotein; Provisional; Region: PRK11023 155864011623 BON domain; Region: BON; pfam04972 155864011624 BON domain; Region: BON; pfam04972 155864011625 Predicted permease; Region: DUF318; pfam03773 155864011626 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 155864011627 NADH(P)-binding; Region: NAD_binding_10; pfam13460 155864011628 NAD binding site [chemical binding]; other site 155864011629 active site 155864011630 intracellular protease, PfpI family; Region: PfpI; TIGR01382 155864011631 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 155864011632 proposed catalytic triad [active] 155864011633 conserved cys residue [active] 155864011634 hypothetical protein; Provisional; Region: PRK03467 155864011635 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 155864011636 GIY-YIG motif/motif A; other site 155864011637 putative active site [active] 155864011638 putative metal binding site [ion binding]; other site 155864011639 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 155864011640 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 155864011641 Coenzyme A binding pocket [chemical binding]; other site 155864011642 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 155864011643 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 155864011644 Peptidase family U32; Region: Peptidase_U32; pfam01136 155864011645 putative protease; Provisional; Region: PRK15447 155864011646 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 155864011647 hypothetical protein; Provisional; Region: PRK10508 155864011648 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 155864011649 tryptophan permease; Provisional; Region: PRK10483 155864011650 aromatic amino acid transport protein; Region: araaP; TIGR00837 155864011651 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 155864011652 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 155864011653 ATP binding site [chemical binding]; other site 155864011654 Mg++ binding site [ion binding]; other site 155864011655 motif III; other site 155864011656 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 155864011657 nucleotide binding region [chemical binding]; other site 155864011658 ATP-binding site [chemical binding]; other site 155864011659 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 155864011660 putative RNA binding site [nucleotide binding]; other site 155864011661 lipoprotein NlpI; Provisional; Region: PRK11189 155864011662 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 155864011663 binding surface 155864011664 TPR motif; other site 155864011665 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 155864011666 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 155864011667 RNase E interface [polypeptide binding]; other site 155864011668 trimer interface [polypeptide binding]; other site 155864011669 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 155864011670 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 155864011671 RNase E interface [polypeptide binding]; other site 155864011672 trimer interface [polypeptide binding]; other site 155864011673 active site 155864011674 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 155864011675 putative nucleic acid binding region [nucleotide binding]; other site 155864011676 G-X-X-G motif; other site 155864011677 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 155864011678 RNA binding site [nucleotide binding]; other site 155864011679 domain interface; other site 155864011680 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 155864011681 16S/18S rRNA binding site [nucleotide binding]; other site 155864011682 S13e-L30e interaction site [polypeptide binding]; other site 155864011683 25S rRNA binding site [nucleotide binding]; other site 155864011684 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 155864011685 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 155864011686 RNA binding site [nucleotide binding]; other site 155864011687 active site 155864011688 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 155864011689 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 155864011690 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 155864011691 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 155864011692 translation initiation factor IF-2; Region: IF-2; TIGR00487 155864011693 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 155864011694 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 155864011695 G1 box; other site 155864011696 putative GEF interaction site [polypeptide binding]; other site 155864011697 GTP/Mg2+ binding site [chemical binding]; other site 155864011698 Switch I region; other site 155864011699 G2 box; other site 155864011700 G3 box; other site 155864011701 Switch II region; other site 155864011702 G4 box; other site 155864011703 G5 box; other site 155864011704 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 155864011705 Translation-initiation factor 2; Region: IF-2; pfam11987 155864011706 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 155864011707 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 155864011708 NusA N-terminal domain; Region: NusA_N; pfam08529 155864011709 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 155864011710 RNA binding site [nucleotide binding]; other site 155864011711 homodimer interface [polypeptide binding]; other site 155864011712 NusA-like KH domain; Region: KH_5; pfam13184 155864011713 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 155864011714 G-X-X-G motif; other site 155864011715 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 155864011716 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 155864011717 ribosome maturation protein RimP; Reviewed; Region: PRK00092 155864011718 Sm and related proteins; Region: Sm_like; cl00259 155864011719 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 155864011720 putative oligomer interface [polypeptide binding]; other site 155864011721 putative RNA binding site [nucleotide binding]; other site 155864011722 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 155864011723 ANP binding site [chemical binding]; other site 155864011724 Substrate Binding Site II [chemical binding]; other site 155864011725 Substrate Binding Site I [chemical binding]; other site 155864011726 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 155864011727 Sulfatase; Region: Sulfatase; pfam00884 155864011728 Preprotein translocase SecG subunit; Region: SecG; pfam03840 155864011729 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 155864011730 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 155864011731 active site 155864011732 substrate binding site [chemical binding]; other site 155864011733 metal binding site [ion binding]; metal-binding site 155864011734 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 155864011735 dihydropteroate synthase; Region: DHPS; TIGR01496 155864011736 substrate binding pocket [chemical binding]; other site 155864011737 dimer interface [polypeptide binding]; other site 155864011738 inhibitor binding site; inhibition site 155864011739 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 155864011740 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 155864011741 Walker A motif; other site 155864011742 ATP binding site [chemical binding]; other site 155864011743 Walker B motif; other site 155864011744 arginine finger; other site 155864011745 Peptidase family M41; Region: Peptidase_M41; pfam01434 155864011746 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 155864011747 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 155864011748 S-adenosylmethionine binding site [chemical binding]; other site 155864011749 RNA-binding protein YhbY; Provisional; Region: PRK10343 155864011750 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 155864011751 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 155864011752 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 155864011753 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 155864011754 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 155864011755 GTPase CgtA; Reviewed; Region: obgE; PRK12298 155864011756 GTP1/OBG; Region: GTP1_OBG; pfam01018 155864011757 Obg GTPase; Region: Obg; cd01898 155864011758 G1 box; other site 155864011759 GTP/Mg2+ binding site [chemical binding]; other site 155864011760 Switch I region; other site 155864011761 G2 box; other site 155864011762 G3 box; other site 155864011763 Switch II region; other site 155864011764 G4 box; other site 155864011765 G5 box; other site 155864011766 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 155864011767 EamA-like transporter family; Region: EamA; pfam00892 155864011768 EamA-like transporter family; Region: EamA; pfam00892 155864011769 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 155864011770 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 155864011771 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 155864011772 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 155864011773 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 155864011774 substrate binding pocket [chemical binding]; other site 155864011775 chain length determination region; other site 155864011776 substrate-Mg2+ binding site; other site 155864011777 catalytic residues [active] 155864011778 aspartate-rich region 1; other site 155864011779 active site lid residues [active] 155864011780 aspartate-rich region 2; other site 155864011781 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 155864011782 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 155864011783 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 155864011784 hinge; other site 155864011785 active site 155864011786 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 155864011787 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 155864011788 anti sigma factor interaction site; other site 155864011789 regulatory phosphorylation site [posttranslational modification]; other site 155864011790 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 155864011791 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 155864011792 mce related protein; Region: MCE; pfam02470 155864011793 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 155864011794 conserved hypothetical integral membrane protein; Region: TIGR00056 155864011795 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 155864011796 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 155864011797 Walker A/P-loop; other site 155864011798 ATP binding site [chemical binding]; other site 155864011799 Q-loop/lid; other site 155864011800 ABC transporter signature motif; other site 155864011801 Walker B; other site 155864011802 D-loop; other site 155864011803 H-loop/switch region; other site 155864011804 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 155864011805 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 155864011806 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 155864011807 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 155864011808 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 155864011809 putative active site [active] 155864011810 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 155864011811 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 155864011812 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 155864011813 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 155864011814 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 155864011815 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 155864011816 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 155864011817 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 155864011818 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 155864011819 Walker A/P-loop; other site 155864011820 ATP binding site [chemical binding]; other site 155864011821 Q-loop/lid; other site 155864011822 ABC transporter signature motif; other site 155864011823 Walker B; other site 155864011824 D-loop; other site 155864011825 H-loop/switch region; other site 155864011826 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 155864011827 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 155864011828 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 155864011829 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 155864011830 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 155864011831 30S subunit binding site; other site 155864011832 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 155864011833 active site 155864011834 phosphorylation site [posttranslational modification] 155864011835 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 155864011836 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 155864011837 dimerization domain swap beta strand [polypeptide binding]; other site 155864011838 regulatory protein interface [polypeptide binding]; other site 155864011839 active site 155864011840 regulatory phosphorylation site [posttranslational modification]; other site 155864011841 hypothetical protein; Provisional; Region: PRK10345 155864011842 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 155864011843 Transglycosylase; Region: Transgly; cl17702 155864011844 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 155864011845 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 155864011846 conserved cys residue [active] 155864011847 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 155864011848 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 155864011849 putative active site [active] 155864011850 heme pocket [chemical binding]; other site 155864011851 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 155864011852 dimer interface [polypeptide binding]; other site 155864011853 phosphorylation site [posttranslational modification] 155864011854 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 155864011855 ATP binding site [chemical binding]; other site 155864011856 Mg2+ binding site [ion binding]; other site 155864011857 G-X-G motif; other site 155864011858 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 155864011859 active site 155864011860 phosphorylation site [posttranslational modification] 155864011861 intermolecular recognition site; other site 155864011862 dimerization interface [polypeptide binding]; other site 155864011863 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 155864011864 putative binding surface; other site 155864011865 active site 155864011866 radical SAM protein, TIGR01212 family; Region: TIGR01212 155864011867 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 155864011868 FeS/SAM binding site; other site 155864011869 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 155864011870 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 155864011871 active site 155864011872 dimer interface [polypeptide binding]; other site 155864011873 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 155864011874 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 155864011875 active site 155864011876 FMN binding site [chemical binding]; other site 155864011877 substrate binding site [chemical binding]; other site 155864011878 3Fe-4S cluster binding site [ion binding]; other site 155864011879 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 155864011880 domain interface; other site 155864011881 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 155864011882 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 155864011883 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 155864011884 O-island #128; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864011885 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 155864011886 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 155864011887 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 155864011888 N-acetylmannosamine kinase; Provisional; Region: PRK05082 155864011889 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 155864011890 nucleotide binding site [chemical binding]; other site 155864011891 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 155864011892 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 155864011893 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 155864011894 putative active site cavity [active] 155864011895 putative sialic acid transporter; Provisional; Region: PRK03893 155864011896 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864011897 putative substrate translocation pore; other site 155864011898 N-acetylneuraminate lyase; Region: nanA; TIGR00683 155864011899 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 155864011900 inhibitor site; inhibition site 155864011901 active site 155864011902 dimer interface [polypeptide binding]; other site 155864011903 catalytic residue [active] 155864011904 transcriptional regulator NanR; Provisional; Region: PRK03837 155864011905 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 155864011906 DNA-binding site [nucleotide binding]; DNA binding site 155864011907 FCD domain; Region: FCD; pfam07729 155864011908 putative cryptic C4-dicarboxylate transporter DcuD; Provisional; Region: PRK09804 155864011909 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 155864011910 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 155864011911 stringent starvation protein A; Provisional; Region: sspA; PRK09481 155864011912 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 155864011913 C-terminal domain interface [polypeptide binding]; other site 155864011914 putative GSH binding site (G-site) [chemical binding]; other site 155864011915 dimer interface [polypeptide binding]; other site 155864011916 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 155864011917 dimer interface [polypeptide binding]; other site 155864011918 N-terminal domain interface [polypeptide binding]; other site 155864011919 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 155864011920 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 155864011921 23S rRNA interface [nucleotide binding]; other site 155864011922 L3 interface [polypeptide binding]; other site 155864011923 Predicted ATPase [General function prediction only]; Region: COG1485 155864011924 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 155864011925 hypothetical protein; Provisional; Region: PRK11677 155864011926 serine endoprotease; Provisional; Region: PRK10139 155864011927 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 155864011928 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 155864011929 protein binding site [polypeptide binding]; other site 155864011930 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 155864011931 serine endoprotease; Provisional; Region: PRK10898 155864011932 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 155864011933 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 155864011934 malate dehydrogenase; Provisional; Region: PRK05086 155864011935 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 155864011936 NAD binding site [chemical binding]; other site 155864011937 dimerization interface [polypeptide binding]; other site 155864011938 Substrate binding site [chemical binding]; other site 155864011939 arginine repressor; Provisional; Region: PRK05066 155864011940 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 155864011941 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 155864011942 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 155864011943 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 155864011944 RNAase interaction site [polypeptide binding]; other site 155864011945 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 155864011946 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 155864011947 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 155864011948 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 155864011949 HlyD family secretion protein; Region: HlyD_3; pfam13437 155864011950 efflux system membrane protein; Provisional; Region: PRK11594 155864011951 transcriptional regulator; Provisional; Region: PRK10632 155864011952 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 155864011953 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 155864011954 putative effector binding pocket; other site 155864011955 dimerization interface [polypeptide binding]; other site 155864011956 protease TldD; Provisional; Region: tldD; PRK10735 155864011957 hypothetical protein; Provisional; Region: PRK10899 155864011958 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 155864011959 ribonuclease G; Provisional; Region: PRK11712 155864011960 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 155864011961 homodimer interface [polypeptide binding]; other site 155864011962 oligonucleotide binding site [chemical binding]; other site 155864011963 Maf-like protein; Region: Maf; pfam02545 155864011964 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 155864011965 active site 155864011966 dimer interface [polypeptide binding]; other site 155864011967 rod shape-determining protein MreD; Provisional; Region: PRK11060 155864011968 rod shape-determining protein MreC; Region: mreC; TIGR00219 155864011969 rod shape-determining protein MreC; Region: MreC; pfam04085 155864011970 rod shape-determining protein MreB; Provisional; Region: PRK13927 155864011971 MreB and similar proteins; Region: MreB_like; cd10225 155864011972 nucleotide binding site [chemical binding]; other site 155864011973 Mg binding site [ion binding]; other site 155864011974 putative protofilament interaction site [polypeptide binding]; other site 155864011975 RodZ interaction site [polypeptide binding]; other site 155864011976 regulatory protein CsrD; Provisional; Region: PRK11059 155864011977 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 155864011978 metal binding site [ion binding]; metal-binding site 155864011979 active site 155864011980 I-site; other site 155864011981 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 155864011982 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 155864011983 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 155864011984 NADP binding site [chemical binding]; other site 155864011985 dimer interface [polypeptide binding]; other site 155864011986 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 155864011987 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 155864011988 carboxyltransferase (CT) interaction site; other site 155864011989 biotinylation site [posttranslational modification]; other site 155864011990 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 155864011991 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 155864011992 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 155864011993 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 155864011994 hypothetical protein; Provisional; Region: PRK10633 155864011995 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 155864011996 Na binding site [ion binding]; other site 155864011997 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 155864011998 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 155864011999 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 155864012000 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 155864012001 FMN binding site [chemical binding]; other site 155864012002 active site 155864012003 catalytic residues [active] 155864012004 substrate binding site [chemical binding]; other site 155864012005 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 155864012006 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 155864012007 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 155864012008 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 155864012009 DNA methylase; Region: N6_N4_Mtase; pfam01555 155864012010 Protein of unknown function (DUF2556); Region: DUF2556; pfam10831 155864012011 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 155864012012 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 155864012013 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 155864012014 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 155864012015 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 155864012016 HlyD family secretion protein; Region: HlyD_3; pfam13437 155864012017 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 155864012018 O-island #129; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864012019 Protein export membrane protein; Region: SecD_SecF; cl14618 155864012020 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 155864012021 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 155864012022 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 155864012023 substrate binding pocket [chemical binding]; other site 155864012024 membrane-bound complex binding site; other site 155864012025 hinge residues; other site 155864012026 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 155864012027 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 155864012028 conserved gate region; other site 155864012029 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 155864012030 dimer interface [polypeptide binding]; other site 155864012031 conserved gate region; other site 155864012032 putative PBP binding loops; other site 155864012033 ABC-ATPase subunit interface; other site 155864012034 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 155864012035 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 155864012036 dimer interface [polypeptide binding]; other site 155864012037 conserved gate region; other site 155864012038 putative PBP binding loops; other site 155864012039 ABC-ATPase subunit interface; other site 155864012040 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 155864012041 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 155864012042 Walker A/P-loop; other site 155864012043 ATP binding site [chemical binding]; other site 155864012044 Q-loop/lid; other site 155864012045 ABC transporter signature motif; other site 155864012046 Walker B; other site 155864012047 D-loop; other site 155864012048 H-loop/switch region; other site 155864012049 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 155864012050 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 155864012051 trimer interface [polypeptide binding]; other site 155864012052 putative metal binding site [ion binding]; other site 155864012053 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 155864012054 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 155864012055 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 155864012056 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 155864012057 shikimate binding site; other site 155864012058 NAD(P) binding site [chemical binding]; other site 155864012059 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 155864012060 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 155864012061 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 155864012062 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 155864012063 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 155864012064 hypothetical protein; Validated; Region: PRK03430 155864012065 hypothetical protein; Provisional; Region: PRK10736 155864012066 DNA protecting protein DprA; Region: dprA; TIGR00732 155864012067 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 155864012068 active site 155864012069 catalytic residues [active] 155864012070 metal binding site [ion binding]; metal-binding site 155864012071 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 155864012072 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 155864012073 putative active site [active] 155864012074 substrate binding site [chemical binding]; other site 155864012075 putative cosubstrate binding site; other site 155864012076 catalytic site [active] 155864012077 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 155864012078 substrate binding site [chemical binding]; other site 155864012079 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 155864012080 putative RNA binding site [nucleotide binding]; other site 155864012081 16S rRNA methyltransferase B; Provisional; Region: PRK10901 155864012082 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 155864012083 S-adenosylmethionine binding site [chemical binding]; other site 155864012084 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 155864012085 TrkA-N domain; Region: TrkA_N; pfam02254 155864012086 TrkA-C domain; Region: TrkA_C; pfam02080 155864012087 TrkA-N domain; Region: TrkA_N; pfam02254 155864012088 TrkA-C domain; Region: TrkA_C; pfam02080 155864012089 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 155864012090 Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741 155864012091 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 155864012092 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 155864012093 DNA binding residues [nucleotide binding] 155864012094 dimer interface [polypeptide binding]; other site 155864012095 metal binding site [ion binding]; metal-binding site 155864012096 hypothetical protein; Provisional; Region: PRK10203 155864012097 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 155864012098 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 155864012099 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 155864012100 alphaNTD homodimer interface [polypeptide binding]; other site 155864012101 alphaNTD - beta interaction site [polypeptide binding]; other site 155864012102 alphaNTD - beta' interaction site [polypeptide binding]; other site 155864012103 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 155864012104 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 155864012105 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 155864012106 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 155864012107 RNA binding surface [nucleotide binding]; other site 155864012108 30S ribosomal protein S11; Validated; Region: PRK05309 155864012109 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 155864012110 30S ribosomal protein S13; Region: bact_S13; TIGR03631 155864012111 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 155864012112 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 155864012113 SecY translocase; Region: SecY; pfam00344 155864012114 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 155864012115 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 155864012116 23S rRNA binding site [nucleotide binding]; other site 155864012117 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 155864012118 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 155864012119 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 155864012120 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 155864012121 23S rRNA interface [nucleotide binding]; other site 155864012122 5S rRNA interface [nucleotide binding]; other site 155864012123 L27 interface [polypeptide binding]; other site 155864012124 L5 interface [polypeptide binding]; other site 155864012125 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 155864012126 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 155864012127 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 155864012128 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 155864012129 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 155864012130 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 155864012131 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 155864012132 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 155864012133 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 155864012134 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 155864012135 RNA binding site [nucleotide binding]; other site 155864012136 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 155864012137 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 155864012138 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 155864012139 23S rRNA interface [nucleotide binding]; other site 155864012140 putative translocon interaction site; other site 155864012141 signal recognition particle (SRP54) interaction site; other site 155864012142 L23 interface [polypeptide binding]; other site 155864012143 trigger factor interaction site; other site 155864012144 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 155864012145 23S rRNA interface [nucleotide binding]; other site 155864012146 5S rRNA interface [nucleotide binding]; other site 155864012147 putative antibiotic binding site [chemical binding]; other site 155864012148 L25 interface [polypeptide binding]; other site 155864012149 L27 interface [polypeptide binding]; other site 155864012150 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 155864012151 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 155864012152 G-X-X-G motif; other site 155864012153 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 155864012154 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 155864012155 protein-rRNA interface [nucleotide binding]; other site 155864012156 putative translocon binding site; other site 155864012157 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 155864012158 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 155864012159 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 155864012160 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 155864012161 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 155864012162 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 155864012163 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 155864012164 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 155864012165 O-island #130; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864012166 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 155864012167 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 155864012168 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 155864012169 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 155864012170 heme binding site [chemical binding]; other site 155864012171 ferroxidase pore; other site 155864012172 ferroxidase diiron center [ion binding]; other site 155864012173 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 155864012174 O-island #131; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864012175 elongation factor Tu; Reviewed; Region: PRK00049 155864012176 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 155864012177 G1 box; other site 155864012178 GEF interaction site [polypeptide binding]; other site 155864012179 GTP/Mg2+ binding site [chemical binding]; other site 155864012180 Switch I region; other site 155864012181 G2 box; other site 155864012182 G3 box; other site 155864012183 Switch II region; other site 155864012184 G4 box; other site 155864012185 G5 box; other site 155864012186 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 155864012187 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 155864012188 Antibiotic Binding Site [chemical binding]; other site 155864012189 elongation factor G; Reviewed; Region: PRK00007 155864012190 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 155864012191 G1 box; other site 155864012192 putative GEF interaction site [polypeptide binding]; other site 155864012193 GTP/Mg2+ binding site [chemical binding]; other site 155864012194 Switch I region; other site 155864012195 G2 box; other site 155864012196 G3 box; other site 155864012197 Switch II region; other site 155864012198 G4 box; other site 155864012199 G5 box; other site 155864012200 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 155864012201 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 155864012202 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 155864012203 30S ribosomal protein S7; Validated; Region: PRK05302 155864012204 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 155864012205 S17 interaction site [polypeptide binding]; other site 155864012206 S8 interaction site; other site 155864012207 16S rRNA interaction site [nucleotide binding]; other site 155864012208 streptomycin interaction site [chemical binding]; other site 155864012209 23S rRNA interaction site [nucleotide binding]; other site 155864012210 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 155864012211 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 155864012212 sulfur relay protein TusC; Validated; Region: PRK00211 155864012213 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 155864012214 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 155864012215 YheO-like PAS domain; Region: PAS_6; pfam08348 155864012216 HTH domain; Region: HTH_22; pfam13309 155864012217 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 155864012218 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 155864012219 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 155864012220 phi X174 lysis protein; Provisional; Region: PRK02793 155864012221 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 155864012222 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 155864012223 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 155864012224 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 155864012225 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 155864012226 TrkA-N domain; Region: TrkA_N; pfam02254 155864012227 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 155864012228 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 155864012229 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 155864012230 Walker A/P-loop; other site 155864012231 ATP binding site [chemical binding]; other site 155864012232 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 155864012233 ABC transporter signature motif; other site 155864012234 Walker B; other site 155864012235 D-loop; other site 155864012236 ABC transporter; Region: ABC_tran_2; pfam12848 155864012237 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 155864012238 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 155864012239 putative hydrolase; Provisional; Region: PRK10985 155864012240 hypothetical protein; Provisional; Region: PRK04966 155864012241 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 155864012242 active site 155864012243 hypothetical protein; Provisional; Region: PRK10738 155864012244 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 155864012245 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 155864012246 ligand binding site [chemical binding]; other site 155864012247 flexible hinge region; other site 155864012248 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 155864012249 putative switch regulator; other site 155864012250 non-specific DNA interactions [nucleotide binding]; other site 155864012251 DNA binding site [nucleotide binding] 155864012252 sequence specific DNA binding site [nucleotide binding]; other site 155864012253 putative cAMP binding site [chemical binding]; other site 155864012254 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 155864012255 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 155864012256 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 155864012257 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 155864012258 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 155864012259 inhibitor-cofactor binding pocket; inhibition site 155864012260 pyridoxal 5'-phosphate binding site [chemical binding]; other site 155864012261 catalytic residue [active] 155864012262 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 155864012263 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 155864012264 glutamine binding [chemical binding]; other site 155864012265 catalytic triad [active] 155864012266 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 155864012267 cell filamentation protein Fic; Provisional; Region: PRK10347 155864012268 hypothetical protein; Provisional; Region: PRK10204 155864012269 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 155864012270 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 155864012271 substrate binding site [chemical binding]; other site 155864012272 putative transporter; Provisional; Region: PRK03699 155864012273 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864012274 putative substrate translocation pore; other site 155864012275 nitrite reductase subunit NirD; Provisional; Region: PRK14989 155864012276 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 155864012277 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 155864012278 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 155864012279 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 155864012280 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 155864012281 nitrite transporter NirC; Provisional; Region: PRK11562 155864012282 siroheme synthase; Provisional; Region: cysG; PRK10637 155864012283 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 155864012284 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 155864012285 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 155864012286 active site 155864012287 SAM binding site [chemical binding]; other site 155864012288 homodimer interface [polypeptide binding]; other site 155864012289 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 155864012290 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 155864012291 hypothetical protein; Provisional; Region: PHA02764 155864012292 fructoselysine-6-P-deglycase; Provisional; Region: frlB; PRK11382 155864012293 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 155864012294 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 155864012295 dimer interface [polypeptide binding]; other site 155864012296 active site 155864012297 fructoselysine 3-epimerase; Provisional; Region: PRK09856 155864012298 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 155864012299 AP (apurinic/apyrimidinic) site pocket; other site 155864012300 DNA interaction; other site 155864012301 Metal-binding active site; metal-binding site 155864012302 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 155864012303 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 155864012304 substrate binding site [chemical binding]; other site 155864012305 ATP binding site [chemical binding]; other site 155864012306 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 155864012307 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 155864012308 DNA-binding site [nucleotide binding]; DNA binding site 155864012309 UTRA domain; Region: UTRA; pfam07702 155864012310 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 155864012311 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 155864012312 active site 155864012313 HIGH motif; other site 155864012314 dimer interface [polypeptide binding]; other site 155864012315 KMSKS motif; other site 155864012316 phosphoglycolate phosphatase; Provisional; Region: PRK13222 155864012317 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 155864012318 motif II; other site 155864012319 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 155864012320 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 155864012321 substrate binding site [chemical binding]; other site 155864012322 hexamer interface [polypeptide binding]; other site 155864012323 metal binding site [ion binding]; metal-binding site 155864012324 DNA adenine methylase; Provisional; Region: PRK10904 155864012325 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 155864012326 cell division protein DamX; Validated; Region: PRK10905 155864012327 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 155864012328 active site 155864012329 dimer interface [polypeptide binding]; other site 155864012330 metal binding site [ion binding]; metal-binding site 155864012331 shikimate kinase; Reviewed; Region: aroK; PRK00131 155864012332 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 155864012333 ADP binding site [chemical binding]; other site 155864012334 magnesium binding site [ion binding]; other site 155864012335 putative shikimate binding site; other site 155864012336 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 155864012337 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 155864012338 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 155864012339 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 155864012340 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 155864012341 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 155864012342 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 155864012343 Transglycosylase; Region: Transgly; pfam00912 155864012344 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 155864012345 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 155864012346 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 155864012347 ADP-ribose binding site [chemical binding]; other site 155864012348 dimer interface [polypeptide binding]; other site 155864012349 active site 155864012350 nudix motif; other site 155864012351 metal binding site [ion binding]; metal-binding site 155864012352 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 155864012353 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 155864012354 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 155864012355 motif II; other site 155864012356 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 155864012357 RNA binding surface [nucleotide binding]; other site 155864012358 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 155864012359 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 155864012360 dimerization interface [polypeptide binding]; other site 155864012361 domain crossover interface; other site 155864012362 redox-dependent activation switch; other site 155864012363 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 155864012364 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 155864012365 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 155864012366 active site 155864012367 substrate-binding site [chemical binding]; other site 155864012368 metal-binding site [ion binding] 155864012369 ATP binding site [chemical binding]; other site 155864012370 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 155864012371 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 155864012372 dimerization interface [polypeptide binding]; other site 155864012373 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 155864012374 dimer interface [polypeptide binding]; other site 155864012375 phosphorylation site [posttranslational modification] 155864012376 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 155864012377 ATP binding site [chemical binding]; other site 155864012378 G-X-G motif; other site 155864012379 osmolarity response regulator; Provisional; Region: ompR; PRK09468 155864012380 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 155864012381 active site 155864012382 phosphorylation site [posttranslational modification] 155864012383 intermolecular recognition site; other site 155864012384 dimerization interface [polypeptide binding]; other site 155864012385 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 155864012386 DNA binding site [nucleotide binding] 155864012387 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 155864012388 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 155864012389 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 155864012390 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 155864012391 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 155864012392 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 155864012393 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 155864012394 RNA binding site [nucleotide binding]; other site 155864012395 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 155864012396 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 155864012397 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 155864012398 G1 box; other site 155864012399 GTP/Mg2+ binding site [chemical binding]; other site 155864012400 Switch I region; other site 155864012401 G2 box; other site 155864012402 G3 box; other site 155864012403 Switch II region; other site 155864012404 G4 box; other site 155864012405 G5 box; other site 155864012406 Nucleoside recognition; Region: Gate; pfam07670 155864012407 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 155864012408 Nucleoside recognition; Region: Gate; pfam07670 155864012409 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 155864012410 putative transposase; Provisional; Region: PRK09857 155864012411 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 155864012412 carboxylesterase BioH; Provisional; Region: PRK10349 155864012413 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 155864012414 DNA utilization protein GntX; Provisional; Region: PRK11595 155864012415 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 155864012416 active site 155864012417 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 155864012418 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 155864012419 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 155864012420 high-affinity gluconate transporter; Provisional; Region: PRK14984 155864012421 gluconate transporter; Region: gntP; TIGR00791 155864012422 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 155864012423 4-alpha-glucanotransferase; Region: malQ; TIGR00217 155864012424 maltodextrin phosphorylase; Provisional; Region: PRK14985 155864012425 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 155864012426 homodimer interface [polypeptide binding]; other site 155864012427 active site pocket [active] 155864012428 transcriptional regulator MalT; Provisional; Region: PRK04841 155864012429 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 155864012430 DNA binding residues [nucleotide binding] 155864012431 O-island #132; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864012432 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 155864012433 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 155864012434 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 155864012435 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 155864012436 putative active site [active] 155864012437 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 155864012438 hypothetical protein; Reviewed; Region: PRK09588 155864012439 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 155864012440 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 155864012441 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 155864012442 Walker A motif; other site 155864012443 ATP binding site [chemical binding]; other site 155864012444 Walker B motif; other site 155864012445 arginine finger; other site 155864012446 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 155864012447 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 155864012448 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 155864012449 intramembrane serine protease GlpG; Provisional; Region: PRK10907 155864012450 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 155864012451 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 155864012452 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 155864012453 active site residue [active] 155864012454 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 155864012455 O-island #133; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864012456 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 155864012457 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 155864012458 O-island #133; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864012459 glycogen phosphorylase; Provisional; Region: PRK14986 155864012460 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 155864012461 homodimer interface [polypeptide binding]; other site 155864012462 active site pocket [active] 155864012463 glycogen synthase; Provisional; Region: glgA; PRK00654 155864012464 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 155864012465 ADP-binding pocket [chemical binding]; other site 155864012466 homodimer interface [polypeptide binding]; other site 155864012467 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 155864012468 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 155864012469 ligand binding site; other site 155864012470 oligomer interface; other site 155864012471 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 155864012472 sulfate 1 binding site; other site 155864012473 glycogen debranching enzyme; Provisional; Region: PRK03705 155864012474 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 155864012475 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 155864012476 active site 155864012477 catalytic site [active] 155864012478 glycogen branching enzyme; Provisional; Region: PRK05402 155864012479 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 155864012480 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 155864012481 active site 155864012482 catalytic site [active] 155864012483 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 155864012484 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 155864012485 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 155864012486 putative antibiotic transporter; Provisional; Region: PRK10739 155864012487 O-island #134; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864012488 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 155864012489 DNA protecting protein DprA; Region: dprA; TIGR00732 155864012490 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 155864012491 non-specific DNA interactions [nucleotide binding]; other site 155864012492 DNA binding site [nucleotide binding] 155864012493 sequence specific DNA binding site [nucleotide binding]; other site 155864012494 putative cAMP binding site [chemical binding]; other site 155864012495 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 155864012496 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 155864012497 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 155864012498 nucleotide binding region [chemical binding]; other site 155864012499 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 155864012500 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 155864012501 ATP binding site [chemical binding]; other site 155864012502 putative Mg++ binding site [ion binding]; other site 155864012503 low affinity gluconate transporter; Provisional; Region: PRK10472 155864012504 gluconate transporter; Region: gntP; TIGR00791 155864012505 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 155864012506 ATP-binding site [chemical binding]; other site 155864012507 Gluconate-6-phosphate binding site [chemical binding]; other site 155864012508 Shikimate kinase; Region: SKI; pfam01202 155864012509 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 155864012510 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 155864012511 DNA binding site [nucleotide binding] 155864012512 domain linker motif; other site 155864012513 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 155864012514 putative ligand binding site [chemical binding]; other site 155864012515 putative dimerization interface [polypeptide binding]; other site 155864012516 Pirin-related protein [General function prediction only]; Region: COG1741 155864012517 Pirin; Region: Pirin; pfam02678 155864012518 putative oxidoreductase; Provisional; Region: PRK10206 155864012519 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 155864012520 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 155864012521 putative acetyltransferase YhhY; Provisional; Region: PRK10140 155864012522 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 155864012523 Coenzyme A binding pocket [chemical binding]; other site 155864012524 O-island #135; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864012525 O-island #135; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864012526 Protein of unknown function (DUF4225); Region: DUF4225; pfam13988 155864012527 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 155864012528 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 155864012529 hypothetical protein; Provisional; Region: PRK10350 155864012530 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 155864012531 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 155864012532 putative active site [active] 155864012533 catalytic site [active] 155864012534 putative metal binding site [ion binding]; other site 155864012535 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 155864012536 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 155864012537 Walker A/P-loop; other site 155864012538 ATP binding site [chemical binding]; other site 155864012539 Q-loop/lid; other site 155864012540 ABC transporter signature motif; other site 155864012541 Walker B; other site 155864012542 D-loop; other site 155864012543 H-loop/switch region; other site 155864012544 TOBE domain; Region: TOBE_2; pfam08402 155864012545 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 155864012546 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 155864012547 dimer interface [polypeptide binding]; other site 155864012548 conserved gate region; other site 155864012549 putative PBP binding loops; other site 155864012550 ABC-ATPase subunit interface; other site 155864012551 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 155864012552 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 155864012553 dimer interface [polypeptide binding]; other site 155864012554 conserved gate region; other site 155864012555 putative PBP binding loops; other site 155864012556 ABC-ATPase subunit interface; other site 155864012557 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 155864012558 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 155864012559 O-island #136; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864012560 Uncharacterized protein conserved in bacteria containing a divergent form of TPR repeats [Function unknown]; Region: COG4700 155864012561 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 155864012562 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 155864012563 binding surface 155864012564 TPR motif; other site 155864012565 O-island #136; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864012566 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 155864012567 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 155864012568 Walker A/P-loop; other site 155864012569 ATP binding site [chemical binding]; other site 155864012570 Q-loop/lid; other site 155864012571 ABC transporter signature motif; other site 155864012572 Walker B; other site 155864012573 D-loop; other site 155864012574 H-loop/switch region; other site 155864012575 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 155864012576 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 155864012577 Walker A/P-loop; other site 155864012578 ATP binding site [chemical binding]; other site 155864012579 Q-loop/lid; other site 155864012580 ABC transporter signature motif; other site 155864012581 Walker B; other site 155864012582 D-loop; other site 155864012583 H-loop/switch region; other site 155864012584 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 155864012585 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 155864012586 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 155864012587 TM-ABC transporter signature motif; other site 155864012588 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 155864012589 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 155864012590 TM-ABC transporter signature motif; other site 155864012591 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 155864012592 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 155864012593 dimerization interface [polypeptide binding]; other site 155864012594 ligand binding site [chemical binding]; other site 155864012595 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 155864012596 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 155864012597 O-island #137; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864012598 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 155864012599 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 155864012600 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 155864012601 dimerization interface [polypeptide binding]; other site 155864012602 ligand binding site [chemical binding]; other site 155864012603 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 155864012604 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 155864012605 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 155864012606 DNA binding residues [nucleotide binding] 155864012607 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 155864012608 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 155864012609 cell division protein FtsE; Provisional; Region: PRK10908 155864012610 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 155864012611 Walker A/P-loop; other site 155864012612 ATP binding site [chemical binding]; other site 155864012613 Q-loop/lid; other site 155864012614 ABC transporter signature motif; other site 155864012615 Walker B; other site 155864012616 D-loop; other site 155864012617 H-loop/switch region; other site 155864012618 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 155864012619 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 155864012620 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 155864012621 P loop; other site 155864012622 GTP binding site [chemical binding]; other site 155864012623 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 155864012624 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 155864012625 S-adenosylmethionine binding site [chemical binding]; other site 155864012626 hypothetical protein; Provisional; Region: PRK10910 155864012627 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 155864012628 Predicted membrane protein [Function unknown]; Region: COG3714 155864012629 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 155864012630 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 155864012631 metal-binding site [ion binding] 155864012632 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 155864012633 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 155864012634 CPxP motif; other site 155864012635 hypothetical protein; Provisional; Region: PRK11212 155864012636 hypothetical protein; Provisional; Region: PRK11615 155864012637 major facilitator superfamily transporter; Provisional; Region: PRK05122 155864012638 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864012639 putative substrate translocation pore; other site 155864012640 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 155864012641 Domain of unknown function DUF20; Region: UPF0118; pfam01594 155864012642 O-island #138; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864012643 O-island #138; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864012644 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 155864012645 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 155864012646 S-adenosylmethionine binding site [chemical binding]; other site 155864012647 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 155864012648 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 155864012649 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 155864012650 putative acyl-acceptor binding pocket; other site 155864012651 Phosphopantetheine attachment site; Region: PP-binding; cl09936 155864012652 acyl carrier protein; Provisional; Region: PRK05350 155864012653 Predicted membrane protein [Function unknown]; Region: COG4648 155864012654 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 155864012655 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 155864012656 acyl-activating enzyme (AAE) consensus motif; other site 155864012657 active site 155864012658 AMP binding site [chemical binding]; other site 155864012659 CoA binding site [chemical binding]; other site 155864012660 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases [Lipid metabolism]; Region: FabA; COG0764 155864012661 active site 2 [active] 155864012662 active site 1 [active] 155864012663 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 155864012664 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 155864012665 Ligand binding site; other site 155864012666 Putative Catalytic site; other site 155864012667 DXD motif; other site 155864012668 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 155864012669 putative acyl-acceptor binding pocket; other site 155864012670 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 155864012671 active site 155864012672 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 155864012673 Predicted exporter [General function prediction only]; Region: COG4258 155864012674 Protein of unknown function (DUF3261); Region: DUF3261; pfam11659 155864012675 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 155864012676 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 155864012677 dimer interface [polypeptide binding]; other site 155864012678 active site 155864012679 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 155864012680 putative active site 1 [active] 155864012681 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 155864012682 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 155864012683 NAD(P) binding site [chemical binding]; other site 155864012684 active site 155864012685 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 155864012686 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 155864012687 dimer interface [polypeptide binding]; other site 155864012688 active site 155864012689 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 155864012690 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 155864012691 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 155864012692 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 155864012693 substrate binding site [chemical binding]; other site 155864012694 nickel transporter permease NikB; Provisional; Region: PRK10352 155864012695 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 155864012696 dimer interface [polypeptide binding]; other site 155864012697 conserved gate region; other site 155864012698 putative PBP binding loops; other site 155864012699 ABC-ATPase subunit interface; other site 155864012700 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 155864012701 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 155864012702 dimer interface [polypeptide binding]; other site 155864012703 conserved gate region; other site 155864012704 putative PBP binding loops; other site 155864012705 ABC-ATPase subunit interface; other site 155864012706 nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418 155864012707 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 155864012708 Walker A/P-loop; other site 155864012709 ATP binding site [chemical binding]; other site 155864012710 Q-loop/lid; other site 155864012711 ABC transporter signature motif; other site 155864012712 Walker B; other site 155864012713 D-loop; other site 155864012714 H-loop/switch region; other site 155864012715 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 155864012716 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 155864012717 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 155864012718 Walker A/P-loop; other site 155864012719 ATP binding site [chemical binding]; other site 155864012720 Q-loop/lid; other site 155864012721 ABC transporter signature motif; other site 155864012722 Walker B; other site 155864012723 D-loop; other site 155864012724 H-loop/switch region; other site 155864012725 nickel responsive regulator; Provisional; Region: PRK02967 155864012726 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 155864012727 O-island #139; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864012728 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 155864012729 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 155864012730 DNA-binding site [nucleotide binding]; DNA binding site 155864012731 UTRA domain; Region: UTRA; pfam07702 155864012732 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 155864012733 active site 155864012734 phosphorylation site [posttranslational modification] 155864012735 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 155864012736 active site 155864012737 P-loop; other site 155864012738 phosphorylation site [posttranslational modification] 155864012739 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 155864012740 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 155864012741 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 155864012742 uncharacterized subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_1; cd07774 155864012743 putative N- and C-terminal domain interface [polypeptide binding]; other site 155864012744 putative active site [active] 155864012745 putative MgATP binding site [chemical binding]; other site 155864012746 catalytic site [active] 155864012747 metal binding site [ion binding]; metal-binding site 155864012748 putative carbohydrate binding site [chemical binding]; other site 155864012749 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 155864012750 dimerization domain swap beta strand [polypeptide binding]; other site 155864012751 regulatory protein interface [polypeptide binding]; other site 155864012752 active site 155864012753 regulatory phosphorylation site [posttranslational modification]; other site 155864012754 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 155864012755 intersubunit interface [polypeptide binding]; other site 155864012756 active site 155864012757 zinc binding site [ion binding]; other site 155864012758 Na+ binding site [ion binding]; other site 155864012759 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 155864012760 HicB family; Region: HicB; pfam05534 155864012761 O-island #139; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864012762 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 155864012763 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 155864012764 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 155864012765 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 155864012766 Walker A/P-loop; other site 155864012767 ATP binding site [chemical binding]; other site 155864012768 Q-loop/lid; other site 155864012769 ABC transporter signature motif; other site 155864012770 Walker B; other site 155864012771 D-loop; other site 155864012772 H-loop/switch region; other site 155864012773 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 155864012774 Walker A/P-loop; other site 155864012775 ATP binding site [chemical binding]; other site 155864012776 Q-loop/lid; other site 155864012777 ABC transporter signature motif; other site 155864012778 Walker B; other site 155864012779 D-loop; other site 155864012780 H-loop/switch region; other site 155864012781 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 155864012782 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 155864012783 HlyD family secretion protein; Region: HlyD; pfam00529 155864012784 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 155864012785 HlyD family secretion protein; Region: HlyD_3; pfam13437 155864012786 Domain of unknown function (DUF4049); Region: DUF4049; pfam13258 155864012787 Domain of unknown function (DUF4049); Region: DUF4049; pfam13258 155864012788 Protein of unknown function (DUF2776); Region: DUF2776; pfam10951 155864012789 Predicted flavoproteins [General function prediction only]; Region: COG2081 155864012790 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 155864012791 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 155864012792 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 155864012793 universal stress protein UspB; Provisional; Region: PRK04960 155864012794 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 155864012795 Ligand Binding Site [chemical binding]; other site 155864012796 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 155864012797 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864012798 POT family; Region: PTR2; pfam00854 155864012799 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 155864012800 S-adenosylmethionine binding site [chemical binding]; other site 155864012801 oligopeptidase A; Provisional; Region: PRK10911 155864012802 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 155864012803 active site 155864012804 Zn binding site [ion binding]; other site 155864012805 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 155864012806 glutathione reductase; Validated; Region: PRK06116 155864012807 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 155864012808 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 155864012809 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 155864012810 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 155864012811 dimerization interface [polypeptide binding]; other site 155864012812 putative DNA binding site [nucleotide binding]; other site 155864012813 putative Zn2+ binding site [ion binding]; other site 155864012814 arsenical pump membrane protein; Provisional; Region: PRK15445 155864012815 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 155864012816 transmembrane helices; other site 155864012817 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 155864012818 ArsC family; Region: ArsC; pfam03960 155864012819 catalytic residues [active] 155864012820 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 155864012821 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 155864012822 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 155864012823 DNA binding residues [nucleotide binding] 155864012824 dimerization interface [polypeptide binding]; other site 155864012825 O-island #140; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864012826 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 155864012827 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 155864012828 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 155864012829 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 155864012830 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 155864012831 N-terminal plug; other site 155864012832 ligand-binding site [chemical binding]; other site 155864012833 O-island #140; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864012834 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 155864012835 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 155864012836 putative hemin binding site; other site 155864012837 coproporphyrinogen III oxidase; Provisional; Region: PRK09058 155864012838 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 155864012839 FeS/SAM binding site; other site 155864012840 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugX; COG3721 155864012841 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 155864012842 NADH(P)-binding; Region: NAD_binding_10; pfam13460 155864012843 NAD(P) binding site [chemical binding]; other site 155864012844 putative active site [active] 155864012845 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 155864012846 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 155864012847 ABC-ATPase subunit interface; other site 155864012848 dimer interface [polypeptide binding]; other site 155864012849 putative PBP binding regions; other site 155864012850 ABC-type hemin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG4559 155864012851 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 155864012852 Walker A/P-loop; other site 155864012853 ATP binding site [chemical binding]; other site 155864012854 Q-loop/lid; other site 155864012855 ABC transporter signature motif; other site 155864012856 Walker B; other site 155864012857 D-loop; other site 155864012858 H-loop/switch region; other site 155864012859 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 155864012860 MgtC family; Region: MgtC; pfam02308 155864012861 acid-resistance protein; Provisional; Region: hdeB; PRK11566 155864012862 acid-resistance protein; Provisional; Region: PRK10208 155864012863 acid-resistance membrane protein; Provisional; Region: PRK10209 155864012864 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 155864012865 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 155864012866 pyruvate kinase; Provisional; Region: PRK05826 155864012867 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 155864012868 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 155864012869 HlyD family secretion protein; Region: HlyD_3; pfam13437 155864012870 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 155864012871 Protein export membrane protein; Region: SecD_SecF; cl14618 155864012872 transcriptional regulator YdeO; Provisional; Region: PRK09940 155864012873 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 155864012874 DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978 155864012875 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 155864012876 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 155864012877 pyridoxal 5'-phosphate binding site [chemical binding]; other site 155864012878 catalytic residue [active] 155864012879 Haem-binding domain; Region: Haem_bd; pfam14376 155864012880 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 155864012881 trehalase; Provisional; Region: treF; PRK13270 155864012882 Trehalase; Region: Trehalase; pfam01204 155864012883 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 155864012884 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 155864012885 DNA binding residues [nucleotide binding] 155864012886 dimerization interface [polypeptide binding]; other site 155864012887 Transcriptional regulator [Transcription]; Region: LysR; COG0583 155864012888 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 155864012889 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 155864012890 putative effector binding pocket; other site 155864012891 putative dimerization interface [polypeptide binding]; other site 155864012892 inner membrane protein YhjD; Region: TIGR00766 155864012893 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864012894 metabolite-proton symporter; Region: 2A0106; TIGR00883 155864012895 putative substrate translocation pore; other site 155864012896 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 155864012897 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 155864012898 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 155864012899 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 155864012900 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 155864012901 substrate binding site [chemical binding]; other site 155864012902 ATP binding site [chemical binding]; other site 155864012903 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 155864012904 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 155864012905 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 155864012906 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 155864012907 putative diguanylate cyclase; Provisional; Region: PRK13561 155864012908 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 155864012909 metal binding site [ion binding]; metal-binding site 155864012910 active site 155864012911 I-site; other site 155864012912 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 155864012913 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 155864012914 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 155864012915 binding surface 155864012916 TPR motif; other site 155864012917 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 155864012918 binding surface 155864012919 TPR motif; other site 155864012920 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 155864012921 endo-1,4-D-glucanase; Provisional; Region: PRK11097 155864012922 cellulose synthase regulator protein; Provisional; Region: PRK11114 155864012923 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 155864012924 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 155864012925 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 155864012926 DXD motif; other site 155864012927 PilZ domain; Region: PilZ; pfam07238 155864012928 cell division protein; Provisional; Region: PRK10037 155864012929 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 155864012930 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 155864012931 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 155864012932 celllulose biosynthesis operon protein BcsF/YhjT; Region: cellullose_BcsF; TIGR03493 155864012933 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 155864012934 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 155864012935 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 155864012936 serine transporter; Region: stp; TIGR00814 155864012937 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 155864012938 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 155864012939 Walker A/P-loop; other site 155864012940 ATP binding site [chemical binding]; other site 155864012941 Q-loop/lid; other site 155864012942 ABC transporter signature motif; other site 155864012943 Walker B; other site 155864012944 D-loop; other site 155864012945 H-loop/switch region; other site 155864012946 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 155864012947 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 155864012948 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 155864012949 Walker A/P-loop; other site 155864012950 ATP binding site [chemical binding]; other site 155864012951 Q-loop/lid; other site 155864012952 ABC transporter signature motif; other site 155864012953 Walker B; other site 155864012954 D-loop; other site 155864012955 H-loop/switch region; other site 155864012956 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 155864012957 dipeptide transporter; Provisional; Region: PRK10913 155864012958 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 155864012959 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 155864012960 dimer interface [polypeptide binding]; other site 155864012961 conserved gate region; other site 155864012962 putative PBP binding loops; other site 155864012963 ABC-ATPase subunit interface; other site 155864012964 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 155864012965 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 155864012966 dimer interface [polypeptide binding]; other site 155864012967 conserved gate region; other site 155864012968 putative PBP binding loops; other site 155864012969 ABC-ATPase subunit interface; other site 155864012970 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 155864012971 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 155864012972 peptide binding site [polypeptide binding]; other site 155864012973 phosphoethanolamine transferase; Provisional; Region: PRK11560 155864012974 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 155864012975 Sulfatase; Region: Sulfatase; pfam00884 155864012976 O-island #141; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864012977 long polar fimbrial protein LpfE; Provisional; Region: PRK15205 155864012978 Fimbrial protein; Region: Fimbrial; cl01416 155864012979 long polar fimbrial outer membrane usher protein LpfC; Provisional; Region: PRK15207 155864012980 PapC N-terminal domain; Region: PapC_N; pfam13954 155864012981 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 155864012982 PapC C-terminal domain; Region: PapC_C; pfam13953 155864012983 long polar fimbrial chaperone LpfB; Provisional; Region: PRK15208 155864012984 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 155864012985 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 155864012986 long polar fimbrial protein LpfA; Provisional; Region: PRK15209 155864012987 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 155864012988 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864012989 putative substrate translocation pore; other site 155864012990 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 155864012991 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 155864012992 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 155864012993 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 155864012994 Coenzyme A binding pocket [chemical binding]; other site 155864012995 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 155864012996 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 155864012997 molybdopterin cofactor binding site [chemical binding]; other site 155864012998 substrate binding site [chemical binding]; other site 155864012999 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 155864013000 molybdopterin cofactor binding site; other site 155864013001 putative outer membrane lipoprotein; Provisional; Region: PRK10510 155864013002 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 155864013003 ligand binding site [chemical binding]; other site 155864013004 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 155864013005 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 155864013006 dimerization interface [polypeptide binding]; other site 155864013007 ligand binding site [chemical binding]; other site 155864013008 NADP binding site [chemical binding]; other site 155864013009 catalytic site [active] 155864013010 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 155864013011 Predicted transcriptional regulator [Transcription]; Region: COG2944 155864013012 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 155864013013 non-specific DNA binding site [nucleotide binding]; other site 155864013014 salt bridge; other site 155864013015 sequence-specific DNA binding site [nucleotide binding]; other site 155864013016 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 155864013017 DNA-binding site [nucleotide binding]; DNA binding site 155864013018 RNA-binding motif; other site 155864013019 small toxic polypeptide; Provisional; Region: PRK09759 155864013020 glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211 155864013021 DALR anticodon binding domain; Region: DALR_1; pfam05746 155864013022 anticodon binding site; other site 155864013023 tRNA binding surface [nucleotide binding]; other site 155864013024 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 155864013025 dimer interface [polypeptide binding]; other site 155864013026 motif 1; other site 155864013027 active site 155864013028 motif 2; other site 155864013029 motif 3; other site 155864013030 YsaB-like lipoprotein; Region: YsaB; pfam13983 155864013031 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 155864013032 Acyltransferase family; Region: Acyl_transf_3; pfam01757 155864013033 hypothetical protein; Provisional; Region: PRK11383 155864013034 yiaA/B two helix domain; Region: YiaAB; pfam05360 155864013035 yiaA/B two helix domain; Region: YiaAB; pfam05360 155864013036 hypothetical protein; Provisional; Region: PRK11403 155864013037 yiaA/B two helix domain; Region: YiaAB; pfam05360 155864013038 xylulokinase; Provisional; Region: PRK15027 155864013039 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 155864013040 N- and C-terminal domain interface [polypeptide binding]; other site 155864013041 active site 155864013042 MgATP binding site [chemical binding]; other site 155864013043 catalytic site [active] 155864013044 metal binding site [ion binding]; metal-binding site 155864013045 xylulose binding site [chemical binding]; other site 155864013046 homodimer interface [polypeptide binding]; other site 155864013047 xylose isomerase; Provisional; Region: PRK05474 155864013048 xylose isomerase; Region: xylose_isom_A; TIGR02630 155864013049 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 155864013050 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 155864013051 putative ligand binding site [chemical binding]; other site 155864013052 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 155864013053 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 155864013054 Walker A/P-loop; other site 155864013055 ATP binding site [chemical binding]; other site 155864013056 Q-loop/lid; other site 155864013057 ABC transporter signature motif; other site 155864013058 Walker B; other site 155864013059 D-loop; other site 155864013060 H-loop/switch region; other site 155864013061 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 155864013062 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 155864013063 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 155864013064 TM-ABC transporter signature motif; other site 155864013065 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 155864013066 putative dimerization interface [polypeptide binding]; other site 155864013067 Transcriptional regulators [Transcription]; Region: PurR; COG1609 155864013068 putative ligand binding site [chemical binding]; other site 155864013069 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 155864013070 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 155864013071 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 155864013072 hypothetical protein; Provisional; Region: PRK10356 155864013073 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 155864013074 alpha-amylase; Reviewed; Region: malS; PRK09505 155864013075 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 155864013076 active site 155864013077 catalytic site [active] 155864013078 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 155864013079 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 155864013080 pyridoxal 5'-phosphate binding site [chemical binding]; other site 155864013081 homodimer interface [polypeptide binding]; other site 155864013082 catalytic residue [active] 155864013083 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 155864013084 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 155864013085 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 155864013086 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 155864013087 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 155864013088 O-island #142; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864013089 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 155864013090 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 155864013091 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 155864013092 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 155864013093 O-island #142; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864013094 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 155864013095 Transcriptional regulator [Transcription]; Region: LysR; COG0583 155864013096 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 155864013097 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 155864013098 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 155864013099 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 155864013100 HlyD family secretion protein; Region: HlyD_3; pfam13437 155864013101 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 155864013102 FlxA-like protein; Region: FlxA; pfam14282 155864013103 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 155864013104 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 155864013105 NAD(P) binding site [chemical binding]; other site 155864013106 catalytic residues [active] 155864013107 Fic family protein [Function unknown]; Region: COG3177 155864013108 Fic/DOC family; Region: Fic; pfam02661 155864013109 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 155864013110 O-island #143; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864013111 putative alcohol dehydrogenase; Provisional; Region: PRK09860 155864013112 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 155864013113 dimer interface [polypeptide binding]; other site 155864013114 active site 155864013115 metal binding site [ion binding]; metal-binding site 155864013116 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 155864013117 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 155864013118 G1 box; other site 155864013119 putative GEF interaction site [polypeptide binding]; other site 155864013120 GTP/Mg2+ binding site [chemical binding]; other site 155864013121 Switch I region; other site 155864013122 G2 box; other site 155864013123 G3 box; other site 155864013124 Switch II region; other site 155864013125 G4 box; other site 155864013126 G5 box; other site 155864013127 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 155864013128 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 155864013129 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 155864013130 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 155864013131 selenocysteine synthase; Provisional; Region: PRK04311 155864013132 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 155864013133 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 155864013134 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 155864013135 catalytic residue [active] 155864013136 putative glutathione S-transferase; Provisional; Region: PRK10357 155864013137 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 155864013138 putative C-terminal domain interface [polypeptide binding]; other site 155864013139 putative GSH binding site (G-site) [chemical binding]; other site 155864013140 putative dimer interface [polypeptide binding]; other site 155864013141 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 155864013142 dimer interface [polypeptide binding]; other site 155864013143 N-terminal domain interface [polypeptide binding]; other site 155864013144 putative substrate binding pocket (H-site) [chemical binding]; other site 155864013145 PAAR motif; Region: PAAR_motif; cl15808 155864013146 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 155864013147 RHS Repeat; Region: RHS_repeat; pfam05593 155864013148 RHS Repeat; Region: RHS_repeat; pfam05593 155864013149 RHS Repeat; Region: RHS_repeat; pfam05593 155864013150 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 155864013151 RHS Repeat; Region: RHS_repeat; pfam05593 155864013152 RHS Repeat; Region: RHS_repeat; pfam05593 155864013153 RHS protein; Region: RHS; pfam03527 155864013154 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 155864013155 putative lyase; Provisional; Region: PRK09687 155864013156 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 155864013157 RHS protein; Region: RHS; pfam03527 155864013158 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 155864013159 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 155864013160 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 155864013161 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 155864013162 HlyD family secretion protein; Region: HlyD_3; pfam13437 155864013163 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 155864013164 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 155864013165 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 155864013166 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 155864013167 active site 155864013168 P-loop; other site 155864013169 phosphorylation site [posttranslational modification] 155864013170 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 155864013171 active site 155864013172 phosphorylation site [posttranslational modification] 155864013173 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 155864013174 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 155864013175 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 155864013176 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 155864013177 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 155864013178 hypothetical protein; Provisional; Region: PRK11020 155864013179 O-island #144; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864013180 Protein of unknown function (DUF3251); Region: DUF3251; cl08186 155864013181 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 155864013182 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 155864013183 trimer interface [polypeptide binding]; other site 155864013184 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 155864013185 trimer interface [polypeptide binding]; other site 155864013186 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 155864013187 trimer interface [polypeptide binding]; other site 155864013188 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 155864013189 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 155864013190 trimer interface [polypeptide binding]; other site 155864013191 Haemagglutinin; Region: HIM; pfam05662 155864013192 Haemagglutinin; Region: HIM; pfam05662 155864013193 YadA-like C-terminal region; Region: YadA; pfam03895 155864013194 L-lactate permease; Provisional; Region: PRK10420 155864013195 glycolate transporter; Provisional; Region: PRK09695 155864013196 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 155864013197 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 155864013198 DNA-binding site [nucleotide binding]; DNA binding site 155864013199 FCD domain; Region: FCD; pfam07729 155864013200 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 155864013201 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 155864013202 phosphate binding site [ion binding]; other site 155864013203 putative rRNA methylase; Provisional; Region: PRK10358 155864013204 serine acetyltransferase; Provisional; Region: cysE; PRK11132 155864013205 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 155864013206 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 155864013207 trimer interface [polypeptide binding]; other site 155864013208 active site 155864013209 substrate binding site [chemical binding]; other site 155864013210 CoA binding site [chemical binding]; other site 155864013211 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 155864013212 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 155864013213 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 155864013214 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 155864013215 SecA binding site; other site 155864013216 Preprotein binding site; other site 155864013217 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 155864013218 GSH binding site [chemical binding]; other site 155864013219 catalytic residues [active] 155864013220 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 155864013221 active site residue [active] 155864013222 phosphoglyceromutase; Provisional; Region: PRK05434 155864013223 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 155864013224 AmiB activator; Provisional; Region: PRK11637 155864013225 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 155864013226 Peptidase family M23; Region: Peptidase_M23; pfam01551 155864013227 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 155864013228 putative active site [active] 155864013229 NodB motif; other site 155864013230 putative glycosyl transferase; Provisional; Region: PRK10073 155864013231 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 155864013232 active site 155864013233 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 155864013234 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 155864013235 NAD(P) binding site [chemical binding]; other site 155864013236 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 155864013237 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 155864013238 substrate-cofactor binding pocket; other site 155864013239 pyridoxal 5'-phosphate binding site [chemical binding]; other site 155864013240 catalytic residue [active] 155864013241 hypothetical protein; Provisional; Region: PRK11346 155864013242 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 155864013243 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 155864013244 NADP binding site [chemical binding]; other site 155864013245 homopentamer interface [polypeptide binding]; other site 155864013246 substrate binding site [chemical binding]; other site 155864013247 active site 155864013248 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 155864013249 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 155864013250 putative active site [active] 155864013251 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 155864013252 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 155864013253 putative active site [active] 155864013254 O-island #145; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864013255 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 155864013256 O-antigen ligase RfaL; Provisional; Region: PRK15487 155864013257 lipopolysaccharide 1,2-N-acetylglucosaminetransferase; Provisional; Region: PRK15484 155864013258 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 155864013259 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 155864013260 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 155864013261 Ligand binding site; other site 155864013262 metal-binding site 155864013263 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 155864013264 Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; pfam06176 155864013265 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 155864013266 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 155864013267 Ligand binding site; other site 155864013268 metal-binding site 155864013269 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 155864013270 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 155864013271 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 155864013272 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 155864013273 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 155864013274 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 155864013275 putative active site [active] 155864013276 O-island #146; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864013277 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 155864013278 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 155864013279 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 155864013280 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 155864013281 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 155864013282 active site 155864013283 (T/H)XGH motif; other site 155864013284 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 155864013285 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 155864013286 DNA binding site [nucleotide binding] 155864013287 catalytic residue [active] 155864013288 H2TH interface [polypeptide binding]; other site 155864013289 putative catalytic residues [active] 155864013290 turnover-facilitating residue; other site 155864013291 intercalation triad [nucleotide binding]; other site 155864013292 8OG recognition residue [nucleotide binding]; other site 155864013293 putative reading head residues; other site 155864013294 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 155864013295 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 155864013296 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 155864013297 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 155864013298 hypothetical protein; Reviewed; Region: PRK00024 155864013299 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 155864013300 MPN+ (JAMM) motif; other site 155864013301 Zinc-binding site [ion binding]; other site 155864013302 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 155864013303 Flavoprotein; Region: Flavoprotein; pfam02441 155864013304 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 155864013305 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 155864013306 trimer interface [polypeptide binding]; other site 155864013307 active site 155864013308 division inhibitor protein; Provisional; Region: slmA; PRK09480 155864013309 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 155864013310 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 155864013311 active site 155864013312 ribonuclease PH; Reviewed; Region: rph; PRK00173 155864013313 Ribonuclease PH; Region: RNase_PH_bact; cd11362 155864013314 hexamer interface [polypeptide binding]; other site 155864013315 active site 155864013316 hypothetical protein; Provisional; Region: PRK11820 155864013317 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 155864013318 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 155864013319 DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525 155864013320 BRO family, N-terminal domain; Region: Bro-N; pfam02498 155864013321 Predicted membrane protein [Function unknown]; Region: COG2860 155864013322 UPF0126 domain; Region: UPF0126; pfam03458 155864013323 UPF0126 domain; Region: UPF0126; pfam03458 155864013324 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 155864013325 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 155864013326 nucleotide binding pocket [chemical binding]; other site 155864013327 K-X-D-G motif; other site 155864013328 catalytic site [active] 155864013329 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 155864013330 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 155864013331 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 155864013332 catalytic site [active] 155864013333 G-X2-G-X-G-K; other site 155864013334 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 155864013335 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 155864013336 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 155864013337 Zn2+ binding site [ion binding]; other site 155864013338 Mg2+ binding site [ion binding]; other site 155864013339 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 155864013340 synthetase active site [active] 155864013341 NTP binding site [chemical binding]; other site 155864013342 metal binding site [ion binding]; metal-binding site 155864013343 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 155864013344 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 155864013345 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 155864013346 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 155864013347 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 155864013348 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 155864013349 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 155864013350 generic binding surface II; other site 155864013351 ssDNA binding site; other site 155864013352 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 155864013353 ATP binding site [chemical binding]; other site 155864013354 putative Mg++ binding site [ion binding]; other site 155864013355 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 155864013356 nucleotide binding region [chemical binding]; other site 155864013357 ATP-binding site [chemical binding]; other site 155864013358 O-island #147; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864013359 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 155864013360 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 155864013361 AsmA family; Region: AsmA; pfam05170 155864013362 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 155864013363 putative alpha-glucosidase; Provisional; Region: PRK10658 155864013364 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 155864013365 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 155864013366 active site 155864013367 homotrimer interface [polypeptide binding]; other site 155864013368 catalytic site [active] 155864013369 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 155864013370 putative transporter; Provisional; Region: PRK11462 155864013371 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 155864013372 O-island #148; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864013373 integrase; Provisional; Region: PRK09692 155864013374 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 155864013375 active site 155864013376 Int/Topo IB signature motif; other site 155864013377 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 155864013378 Transposase; Region: HTH_Tnp_1; cl17663 155864013379 Integrase core domain; Region: rve; pfam00665 155864013380 DDE domain; Region: DDE_Tnp_IS240; pfam13610 155864013381 Integrase core domain; Region: rve_3; pfam13683 155864013382 O-island #148; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864013383 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 155864013384 Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117 155864013385 Methyltransferase domain; Region: Methyltransf_27; pfam13708 155864013386 Methyltransferase domain; Region: Methyltransf_27; pfam13708 155864013387 Transposase; Region: HTH_Tnp_1; pfam01527 155864013388 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 155864013389 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 155864013390 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 155864013391 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 155864013392 homodimer interface [polypeptide binding]; other site 155864013393 putative GKAP docking site [polypeptide binding]; other site 155864013394 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 155864013395 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 155864013396 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 155864013397 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 155864013398 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 155864013399 type III secretion system protein, SsaH family; Region: type_III_ssaH; TIGR02498 155864013400 type III secretion apparatus needle protein; Region: III_needle; TIGR02105 155864013401 pathogenicity island 2 effector protein SseE; Provisional; Region: PRK15360 155864013402 Enterobacterial EspB protein; Region: EspB; pfam05802 155864013403 Uncharacterized conserved protein [Function unknown]; Region: COG5613 155864013404 EspA-like secreted protein; Region: EspA; pfam03433 155864013405 HrpJ-like domain; Region: HrpJ; pfam07201 155864013406 type III secretion effector delivery regulator, TyeA family; Region: type_III_tyeA; TIGR02511 155864013407 O-island #148; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864013408 type III secretion system protein SsaD; Provisional; Region: PRK15367 155864013409 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 155864013410 LysM domain; Region: LysM; pfam01476 155864013411 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 155864013412 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 155864013413 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 155864013414 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 155864013415 Intimin C-type lectin domain; Region: Intimin_C; pfam07979 155864013416 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 155864013417 Translocated intimin receptor (Tir) N-terminus; Region: Tir_receptor_N; pfam07490 155864013418 Translocated intimin receptor (Tir) intimin-binding domain; Region: Tir_receptor_M; pfam03549 155864013419 Translocated intimin receptor (Tir) C-terminus; Region: Tir_receptor_C; pfam07489 155864013420 IpaB/EvcA family; Region: IpaB_EvcA; pfam03278 155864013421 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 155864013422 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 155864013423 Protein of unknown function (DUF1106); Region: DUF1106; pfam06523 155864013424 O-island #148; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864013425 type III secretion apparatus H+-transporting two-sector ATPase; Region: III_secr_ATP; TIGR02546 155864013426 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 155864013427 Walker A motif/ATP binding site; other site 155864013428 Walker B motif; other site 155864013429 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 155864013430 FHIPEP family; Region: FHIPEP; pfam00771 155864013431 SepZ; Region: SepZ; pfam06066 155864013432 Type III secretory pathway, lipoprotein EscJ [Intracellular trafficking and secretion]; Region: EscJ; COG4669 155864013433 outer membrane secretin SsaC; Provisional; Region: PRK15346 155864013434 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 155864013435 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 155864013436 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 155864013437 Tetratricopeptide repeat; Region: TPR_3; pfam07720 155864013438 Protein of unknown function (DUF1401); Region: DUF1401; pfam07180 155864013439 negative regulator GrlR; Provisional; Region: PRK14051 155864013440 O-island #148; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864013441 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 155864013442 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 155864013443 N-acetyl-D-glucosamine binding site [chemical binding]; other site 155864013444 catalytic residue [active] 155864013445 secretion system apparatus protein SsaU; Reviewed; Region: PRK12721 155864013446 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 155864013447 type III secretion protein SpaR/YscT/HrcT; Region: fliR_like_III; TIGR01401 155864013448 Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794 155864013449 Type III secretory pathway, component EscR [Intracellular trafficking and secretion]; Region: EscR; COG4790 155864013450 Type III secretion system subunit; Region: T3SS_LEE_assoc; pfam13327 155864013451 Type III secretion system filament chaperone CesA; Region: CesA; pfam11439 155864013452 type III secretion system protein, YseE family; Region: type_III_yscE; TIGR02501 155864013453 DNA-binding protein H-NS [General function prediction only]; Region: Hns; COG2916 155864013454 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 155864013455 EspG protein; Region: EspG; pfam06872 155864013456 SdiA-regulated; Region: SdiA-regulated; cd09971 155864013457 SdiA-regulated; Region: SdiA-regulated; pfam06977 155864013458 putative active site [active] 155864013459 EamA-like transporter family; Region: EamA; pfam00892 155864013460 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 155864013461 EamA-like transporter family; Region: EamA; pfam00892 155864013462 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 155864013463 lipoprotein, YaeC family; Region: TIGR00363 155864013464 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 155864013465 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864013466 putative substrate translocation pore; other site 155864013467 O-island #149; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864013468 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4737 155864013469 Predicted transcriptional regulator [Transcription]; Region: COG2944 155864013470 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 155864013471 non-specific DNA binding site [nucleotide binding]; other site 155864013472 salt bridge; other site 155864013473 sequence-specific DNA binding site [nucleotide binding]; other site 155864013474 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 155864013475 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 155864013476 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 155864013477 cryptic adenine deaminase; Provisional; Region: PRK10027 155864013478 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 155864013479 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 155864013480 active site 155864013481 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 155864013482 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 155864013483 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864013484 putative substrate translocation pore; other site 155864013485 regulatory protein UhpC; Provisional; Region: PRK11663 155864013486 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864013487 putative substrate translocation pore; other site 155864013488 sensory histidine kinase UhpB; Provisional; Region: PRK11644 155864013489 MASE1; Region: MASE1; pfam05231 155864013490 Histidine kinase; Region: HisKA_3; pfam07730 155864013491 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 155864013492 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 155864013493 active site 155864013494 phosphorylation site [posttranslational modification] 155864013495 intermolecular recognition site; other site 155864013496 dimerization interface [polypeptide binding]; other site 155864013497 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 155864013498 DNA binding residues [nucleotide binding] 155864013499 dimerization interface [polypeptide binding]; other site 155864013500 O-island #150; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864013501 O-island #150; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864013502 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 155864013503 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 155864013504 putative valine binding site [chemical binding]; other site 155864013505 dimer interface [polypeptide binding]; other site 155864013506 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 155864013507 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 155864013508 PYR/PP interface [polypeptide binding]; other site 155864013509 dimer interface [polypeptide binding]; other site 155864013510 TPP binding site [chemical binding]; other site 155864013511 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 155864013512 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 155864013513 TPP-binding site [chemical binding]; other site 155864013514 dimer interface [polypeptide binding]; other site 155864013515 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 155864013516 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864013517 putative substrate translocation pore; other site 155864013518 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 155864013519 Domain of unknown function (DUF202); Region: DUF202; pfam02656 155864013520 Predicted membrane protein [Function unknown]; Region: COG2149 155864013521 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 155864013522 Sulfatase; Region: Sulfatase; pfam00884 155864013523 putative transporter; Provisional; Region: PRK10484 155864013524 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 155864013525 Na binding site [ion binding]; other site 155864013526 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 155864013527 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 155864013528 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 155864013529 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 155864013530 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 155864013531 NAD binding site [chemical binding]; other site 155864013532 sugar binding site [chemical binding]; other site 155864013533 divalent metal binding site [ion binding]; other site 155864013534 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 155864013535 dimer interface [polypeptide binding]; other site 155864013536 O-island #151; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864013537 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 155864013538 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 155864013539 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 155864013540 active site turn [active] 155864013541 phosphorylation site [posttranslational modification] 155864013542 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 155864013543 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 155864013544 DNA-binding site [nucleotide binding]; DNA binding site 155864013545 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 155864013546 putative transporter; Validated; Region: PRK03818 155864013547 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 155864013548 TrkA-C domain; Region: TrkA_C; pfam02080 155864013549 TrkA-C domain; Region: TrkA_C; pfam02080 155864013550 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 155864013551 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 155864013552 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 155864013553 putative dimer interface [polypeptide binding]; other site 155864013554 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 155864013555 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 155864013556 putative dimer interface [polypeptide binding]; other site 155864013557 hypothetical protein; Provisional; Region: PRK11616 155864013558 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 155864013559 putative oxidoreductase; Provisional; Region: PRK11445 155864013560 hypothetical protein; Provisional; Region: PRK07236 155864013561 hypothetical protein; Provisional; Region: PRK10215 155864013562 sugar phosphate phosphatase; Provisional; Region: PRK10513 155864013563 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 155864013564 active site 155864013565 motif I; other site 155864013566 motif II; other site 155864013567 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 155864013568 hypothetical protein; Provisional; Region: PRK11426 155864013569 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 155864013570 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 155864013571 Mg2+ binding site [ion binding]; other site 155864013572 G-X-G motif; other site 155864013573 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 155864013574 anchoring element; other site 155864013575 dimer interface [polypeptide binding]; other site 155864013576 ATP binding site [chemical binding]; other site 155864013577 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 155864013578 active site 155864013579 putative metal-binding site [ion binding]; other site 155864013580 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 155864013581 recF protein; Region: recf; TIGR00611 155864013582 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 155864013583 Walker A/P-loop; other site 155864013584 ATP binding site [chemical binding]; other site 155864013585 Q-loop/lid; other site 155864013586 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 155864013587 ABC transporter signature motif; other site 155864013588 Walker B; other site 155864013589 D-loop; other site 155864013590 H-loop/switch region; other site 155864013591 DNA polymerase III subunit beta; Validated; Region: PRK05643 155864013592 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 155864013593 putative DNA binding surface [nucleotide binding]; other site 155864013594 dimer interface [polypeptide binding]; other site 155864013595 beta-clamp/clamp loader binding surface; other site 155864013596 beta-clamp/translesion DNA polymerase binding surface; other site 155864013597 DnaA N-terminal domain; Region: DnaA_N; pfam11638 155864013598 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 155864013599 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 155864013600 Walker A motif; other site 155864013601 ATP binding site [chemical binding]; other site 155864013602 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 155864013603 Walker B motif; other site 155864013604 arginine finger; other site 155864013605 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 155864013606 DnaA box-binding interface [nucleotide binding]; other site 155864013607 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 155864013608 ribonuclease P; Reviewed; Region: rnpA; PRK01732 155864013609 membrane protein insertase; Provisional; Region: PRK01318 155864013610 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 155864013611 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 155864013612 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 155864013613 trmE is a tRNA modification GTPase; Region: trmE; cd04164 155864013614 G1 box; other site 155864013615 GTP/Mg2+ binding site [chemical binding]; other site 155864013616 Switch I region; other site 155864013617 G2 box; other site 155864013618 Switch II region; other site 155864013619 G3 box; other site 155864013620 G4 box; other site 155864013621 G5 box; other site 155864013622 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 155864013623 O-island #152; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864013624 O-island #152; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864013625 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 155864013626 Tryptophanese operon leader peptide; Region: Tna_leader; pfam08053 155864013627 tryptophanase, leader peptide-associated; Region: tnaA_trp_ase; TIGR02617 155864013628 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 155864013629 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 155864013630 catalytic residue [active] 155864013631 tryptophan permease TnaB; Provisional; Region: PRK09664 155864013632 aromatic amino acid transport protein; Region: araaP; TIGR00837 155864013633 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 155864013634 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864013635 putative substrate translocation pore; other site 155864013636 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 155864013637 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 155864013638 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 155864013639 substrate binding pocket [chemical binding]; other site 155864013640 dimerization interface [polypeptide binding]; other site 155864013641 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 155864013642 Predicted flavoprotein [General function prediction only]; Region: COG0431 155864013643 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 155864013644 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 155864013645 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 155864013646 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 155864013647 active site 155864013648 motif I; other site 155864013649 motif II; other site 155864013650 O-island #153; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864013651 Salmonella outer protein D; Region: SopD; cl14701 155864013652 transcriptional regulator PhoU; Provisional; Region: PRK11115 155864013653 PhoU domain; Region: PhoU; pfam01895 155864013654 PhoU domain; Region: PhoU; pfam01895 155864013655 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 155864013656 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 155864013657 Walker A/P-loop; other site 155864013658 ATP binding site [chemical binding]; other site 155864013659 Q-loop/lid; other site 155864013660 ABC transporter signature motif; other site 155864013661 Walker B; other site 155864013662 D-loop; other site 155864013663 H-loop/switch region; other site 155864013664 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 155864013665 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 155864013666 dimer interface [polypeptide binding]; other site 155864013667 conserved gate region; other site 155864013668 putative PBP binding loops; other site 155864013669 ABC-ATPase subunit interface; other site 155864013670 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 155864013671 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 155864013672 dimer interface [polypeptide binding]; other site 155864013673 conserved gate region; other site 155864013674 putative PBP binding loops; other site 155864013675 ABC-ATPase subunit interface; other site 155864013676 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 155864013677 O-island #154; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864013678 Fimbrial protein; Region: Fimbrial; cl01416 155864013679 Fimbrial protein; Region: Fimbrial; cl01416 155864013680 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 155864013681 PapC N-terminal domain; Region: PapC_N; pfam13954 155864013682 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 155864013683 PapC C-terminal domain; Region: PapC_C; pfam13953 155864013684 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 155864013685 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 155864013686 fimbrial protein; Provisional; Region: lpfA; PRK15289 155864013687 similar to hypothetical protein; No significant matches 155864013688 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 155864013689 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 155864013690 glutaminase active site [active] 155864013691 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 155864013692 dimer interface [polypeptide binding]; other site 155864013693 active site 155864013694 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 155864013695 dimer interface [polypeptide binding]; other site 155864013696 active site 155864013697 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 155864013698 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 155864013699 Substrate binding site; other site 155864013700 Mg++ binding site; other site 155864013701 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 155864013702 active site 155864013703 substrate binding site [chemical binding]; other site 155864013704 CoA binding site [chemical binding]; other site 155864013705 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 155864013706 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 155864013707 gamma subunit interface [polypeptide binding]; other site 155864013708 epsilon subunit interface [polypeptide binding]; other site 155864013709 LBP interface [polypeptide binding]; other site 155864013710 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 155864013711 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 155864013712 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 155864013713 alpha subunit interaction interface [polypeptide binding]; other site 155864013714 Walker A motif; other site 155864013715 ATP binding site [chemical binding]; other site 155864013716 Walker B motif; other site 155864013717 inhibitor binding site; inhibition site 155864013718 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 155864013719 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 155864013720 core domain interface [polypeptide binding]; other site 155864013721 delta subunit interface [polypeptide binding]; other site 155864013722 epsilon subunit interface [polypeptide binding]; other site 155864013723 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 155864013724 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 155864013725 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 155864013726 beta subunit interaction interface [polypeptide binding]; other site 155864013727 Walker A motif; other site 155864013728 ATP binding site [chemical binding]; other site 155864013729 Walker B motif; other site 155864013730 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 155864013731 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 155864013732 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 155864013733 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 155864013734 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 155864013735 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 155864013736 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 155864013737 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 155864013738 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 155864013739 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 155864013740 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 155864013741 S-adenosylmethionine binding site [chemical binding]; other site 155864013742 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 155864013743 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 155864013744 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 155864013745 FMN-binding protein MioC; Provisional; Region: PRK09004 155864013746 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 155864013747 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 155864013748 putative DNA binding site [nucleotide binding]; other site 155864013749 putative Zn2+ binding site [ion binding]; other site 155864013750 AsnC family; Region: AsnC_trans_reg; pfam01037 155864013751 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 155864013752 dimer interface [polypeptide binding]; other site 155864013753 active site 155864013754 hypothetical protein; Provisional; Region: yieM; PRK10997 155864013755 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 155864013756 metal ion-dependent adhesion site (MIDAS); other site 155864013757 regulatory ATPase RavA; Provisional; Region: PRK13531 155864013758 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 155864013759 Walker A motif; other site 155864013760 ATP binding site [chemical binding]; other site 155864013761 Walker B motif; other site 155864013762 arginine finger; other site 155864013763 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 155864013764 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 155864013765 potassium uptake protein; Region: kup; TIGR00794 155864013766 D-ribose pyranase; Provisional; Region: PRK11797 155864013767 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 155864013768 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 155864013769 Walker A/P-loop; other site 155864013770 ATP binding site [chemical binding]; other site 155864013771 Q-loop/lid; other site 155864013772 ABC transporter signature motif; other site 155864013773 Walker B; other site 155864013774 D-loop; other site 155864013775 H-loop/switch region; other site 155864013776 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 155864013777 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 155864013778 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 155864013779 TM-ABC transporter signature motif; other site 155864013780 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 155864013781 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 155864013782 ligand binding site [chemical binding]; other site 155864013783 dimerization interface [polypeptide binding]; other site 155864013784 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 155864013785 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 155864013786 substrate binding site [chemical binding]; other site 155864013787 dimer interface [polypeptide binding]; other site 155864013788 ATP binding site [chemical binding]; other site 155864013789 transcriptional repressor RbsR; Provisional; Region: PRK10423 155864013790 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 155864013791 DNA binding site [nucleotide binding] 155864013792 domain linker motif; other site 155864013793 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 155864013794 dimerization interface [polypeptide binding]; other site 155864013795 ligand binding site [chemical binding]; other site 155864013796 putative transporter; Provisional; Region: PRK10504 155864013797 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864013798 putative substrate translocation pore; other site 155864013799 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864013800 Transcriptional regulators [Transcription]; Region: FadR; COG2186 155864013801 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 155864013802 DNA-binding site [nucleotide binding]; DNA binding site 155864013803 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 155864013804 transcriptional regulator HdfR; Provisional; Region: PRK03601 155864013805 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 155864013806 LysR substrate binding domain; Region: LysR_substrate; pfam03466 155864013807 dimerization interface [polypeptide binding]; other site 155864013808 hypothetical protein; Provisional; Region: PRK11027 155864013809 putative ATP-dependent protease; Provisional; Region: PRK09862 155864013810 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 155864013811 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 155864013812 Walker A motif; other site 155864013813 ATP binding site [chemical binding]; other site 155864013814 Walker B motif; other site 155864013815 arginine finger; other site 155864013816 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 155864013817 ilvG operon leader peptide; Provisional; Region: PRK10424 155864013818 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 155864013819 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 155864013820 PYR/PP interface [polypeptide binding]; other site 155864013821 dimer interface [polypeptide binding]; other site 155864013822 TPP binding site [chemical binding]; other site 155864013823 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 155864013824 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 155864013825 TPP-binding site [chemical binding]; other site 155864013826 dimer interface [polypeptide binding]; other site 155864013827 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 155864013828 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 155864013829 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 155864013830 homodimer interface [polypeptide binding]; other site 155864013831 substrate-cofactor binding pocket; other site 155864013832 catalytic residue [active] 155864013833 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 155864013834 threonine dehydratase; Reviewed; Region: PRK09224 155864013835 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 155864013836 tetramer interface [polypeptide binding]; other site 155864013837 pyridoxal 5'-phosphate binding site [chemical binding]; other site 155864013838 catalytic residue [active] 155864013839 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 155864013840 putative Ile/Val binding site [chemical binding]; other site 155864013841 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 155864013842 putative Ile/Val binding site [chemical binding]; other site 155864013843 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 155864013844 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 155864013845 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 155864013846 putative dimerization interface [polypeptide binding]; other site 155864013847 ketol-acid reductoisomerase; Validated; Region: PRK05225 155864013848 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 155864013849 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 155864013850 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 155864013851 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 155864013852 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 155864013853 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3692 155864013854 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 155864013855 Part of AAA domain; Region: AAA_19; pfam13245 155864013856 Family description; Region: UvrD_C_2; pfam13538 155864013857 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 155864013858 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 155864013859 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 155864013860 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 155864013861 ATP binding site [chemical binding]; other site 155864013862 Mg++ binding site [ion binding]; other site 155864013863 motif III; other site 155864013864 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 155864013865 nucleotide binding region [chemical binding]; other site 155864013866 ATP-binding site [chemical binding]; other site 155864013867 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 155864013868 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 155864013869 catalytic residues [active] 155864013870 putative rho operon leader peptide; Provisional; Region: PRK09979 155864013871 transcription termination factor Rho; Provisional; Region: rho; PRK09376 155864013872 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 155864013873 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 155864013874 RNA binding site [nucleotide binding]; other site 155864013875 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 155864013876 multimer interface [polypeptide binding]; other site 155864013877 Walker A motif; other site 155864013878 ATP binding site [chemical binding]; other site 155864013879 Walker B motif; other site 155864013880 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 155864013881 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 155864013882 Mg++ binding site [ion binding]; other site 155864013883 putative catalytic motif [active] 155864013884 substrate binding site [chemical binding]; other site 155864013885 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 155864013886 Chain length determinant protein; Region: Wzz; pfam02706 155864013887 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 155864013888 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 155864013889 active site 155864013890 homodimer interface [polypeptide binding]; other site 155864013891 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 155864013892 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 155864013893 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 155864013894 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 155864013895 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 155864013896 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 155864013897 NAD binding site [chemical binding]; other site 155864013898 substrate binding site [chemical binding]; other site 155864013899 homodimer interface [polypeptide binding]; other site 155864013900 active site 155864013901 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 155864013902 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 155864013903 substrate binding site; other site 155864013904 tetramer interface; other site 155864013905 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 155864013906 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 155864013907 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 155864013908 inhibitor-cofactor binding pocket; inhibition site 155864013909 pyridoxal 5'-phosphate binding site [chemical binding]; other site 155864013910 catalytic residue [active] 155864013911 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 155864013912 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 155864013913 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 155864013914 putative common antigen polymerase; Provisional; Region: PRK02975 155864013915 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 155864013916 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 155864013917 putative transport protein YifK; Provisional; Region: PRK10746 155864013918 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 155864013919 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 155864013920 FeS/SAM binding site; other site 155864013921 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 155864013922 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 155864013923 Sulfatase; Region: Sulfatase; pfam00884 155864013924 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 155864013925 HemY protein N-terminus; Region: HemY_N; pfam07219 155864013926 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 155864013927 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 155864013928 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 155864013929 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 155864013930 active site 155864013931 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 155864013932 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 155864013933 domain interfaces; other site 155864013934 active site 155864013935 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 155864013936 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 155864013937 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 155864013938 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 155864013939 putative iron binding site [ion binding]; other site 155864013940 hypothetical protein; Provisional; Region: PRK09807 155864013941 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 155864013942 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 155864013943 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 155864013944 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 155864013945 hypothetical protein; Provisional; Region: PRK10963 155864013946 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 155864013947 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 155864013948 active site 155864013949 DNA binding site [nucleotide binding] 155864013950 Int/Topo IB signature motif; other site 155864013951 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 155864013952 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 155864013953 motif II; other site 155864013954 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 155864013955 Part of AAA domain; Region: AAA_19; pfam13245 155864013956 Family description; Region: UvrD_C_2; pfam13538 155864013957 O-island #155; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864013958 Uncharacterized conserved protein [Function unknown]; Region: COG1912 155864013959 O-island #155; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864013960 Predicted periplasmic protein [Function unknown]; Region: COG3698 155864013961 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 155864013962 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 155864013963 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 155864013964 Cl binding site [ion binding]; other site 155864013965 oligomer interface [polypeptide binding]; other site 155864013966 O-island #156; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864013967 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 155864013968 conserved hypothetical protein; Region: TIGR03034 155864013969 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 155864013970 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085 155864013971 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 155864013972 EamA-like transporter family; Region: EamA; cl17759 155864013973 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 155864013974 CoenzymeA binding site [chemical binding]; other site 155864013975 subunit interaction site [polypeptide binding]; other site 155864013976 PHB binding site; other site 155864013977 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 155864013978 dimerization interface [polypeptide binding]; other site 155864013979 substrate binding site [chemical binding]; other site 155864013980 active site 155864013981 calcium binding site [ion binding]; other site 155864013982 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 155864013983 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 155864013984 ATP binding site [chemical binding]; other site 155864013985 putative Mg++ binding site [ion binding]; other site 155864013986 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 155864013987 nucleotide binding region [chemical binding]; other site 155864013988 ATP-binding site [chemical binding]; other site 155864013989 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 155864013990 Helicase and RNase D C-terminal; Region: HRDC; smart00341 155864013991 LysE type translocator; Region: LysE; cl00565 155864013992 LysE type translocator; Region: LysE; cl00565 155864013993 lysophospholipase L2; Provisional; Region: PRK10749 155864013994 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 155864013995 putative hydrolase; Provisional; Region: PRK10976 155864013996 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 155864013997 active site 155864013998 motif I; other site 155864013999 motif II; other site 155864014000 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 155864014001 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 155864014002 EamA-like transporter family; Region: EamA; pfam00892 155864014003 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 155864014004 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 155864014005 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 155864014006 putative dimerization interface [polypeptide binding]; other site 155864014007 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 155864014008 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 155864014009 THF binding site; other site 155864014010 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 155864014011 substrate binding site [chemical binding]; other site 155864014012 THF binding site; other site 155864014013 zinc-binding site [ion binding]; other site 155864014014 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 155864014015 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 155864014016 uridine phosphorylase; Provisional; Region: PRK11178 155864014017 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 155864014018 DNA recombination protein RmuC; Provisional; Region: PRK10361 155864014019 RmuC family; Region: RmuC; pfam02646 155864014020 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 155864014021 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 155864014022 S-adenosylmethionine binding site [chemical binding]; other site 155864014023 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 155864014024 SCP-2 sterol transfer family; Region: SCP2; pfam02036 155864014025 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 155864014026 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 155864014027 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 155864014028 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 155864014029 sec-independent translocase; Provisional; Region: PRK01770 155864014030 sec-independent translocase; Provisional; Region: tatB; PRK00404 155864014031 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 155864014032 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 155864014033 active site 155864014034 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 155864014035 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 155864014036 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 155864014037 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 155864014038 FMN reductase; Validated; Region: fre; PRK08051 155864014039 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 155864014040 FAD binding pocket [chemical binding]; other site 155864014041 FAD binding motif [chemical binding]; other site 155864014042 phosphate binding motif [ion binding]; other site 155864014043 beta-alpha-beta structure motif; other site 155864014044 NAD binding pocket [chemical binding]; other site 155864014045 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 155864014046 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 155864014047 dimer interface [polypeptide binding]; other site 155864014048 active site 155864014049 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 155864014050 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 155864014051 substrate binding site [chemical binding]; other site 155864014052 oxyanion hole (OAH) forming residues; other site 155864014053 trimer interface [polypeptide binding]; other site 155864014054 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 155864014055 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 155864014056 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 155864014057 proline dipeptidase; Provisional; Region: PRK13607 155864014058 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 155864014059 active site 155864014060 hypothetical protein; Provisional; Region: PRK11568 155864014061 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 155864014062 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 155864014063 potassium transporter; Provisional; Region: PRK10750 155864014064 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 155864014065 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 155864014066 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 155864014067 Walker A motif; other site 155864014068 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 155864014069 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 155864014070 GTP binding site; other site 155864014071 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 155864014072 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 155864014073 serine/threonine protein kinase; Provisional; Region: PRK11768 155864014074 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 155864014075 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 155864014076 catalytic residues [active] 155864014077 hinge region; other site 155864014078 alpha helical domain; other site 155864014079 hypothetical protein; Provisional; Region: PRK11367 155864014080 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 155864014081 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 155864014082 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 155864014083 putative acyl-acceptor binding pocket; other site 155864014084 DNA polymerase I; Provisional; Region: PRK05755 155864014085 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 155864014086 active site 155864014087 metal binding site 1 [ion binding]; metal-binding site 155864014088 putative 5' ssDNA interaction site; other site 155864014089 metal binding site 3; metal-binding site 155864014090 metal binding site 2 [ion binding]; metal-binding site 155864014091 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 155864014092 putative DNA binding site [nucleotide binding]; other site 155864014093 putative metal binding site [ion binding]; other site 155864014094 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 155864014095 active site 155864014096 catalytic site [active] 155864014097 substrate binding site [chemical binding]; other site 155864014098 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 155864014099 active site 155864014100 DNA binding site [nucleotide binding] 155864014101 catalytic site [active] 155864014102 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 155864014103 G1 box; other site 155864014104 GTP/Mg2+ binding site [chemical binding]; other site 155864014105 Switch I region; other site 155864014106 G2 box; other site 155864014107 G3 box; other site 155864014108 Switch II region; other site 155864014109 G4 box; other site 155864014110 G5 box; other site 155864014111 similar to hypothetical protein; No significant matches 155864014112 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078 155864014113 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 155864014114 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 155864014115 FeS/SAM binding site; other site 155864014116 HemN C-terminal domain; Region: HemN_C; pfam06969 155864014117 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 155864014118 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 155864014119 active site 155864014120 phosphorylation site [posttranslational modification] 155864014121 intermolecular recognition site; other site 155864014122 dimerization interface [polypeptide binding]; other site 155864014123 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 155864014124 Walker A motif; other site 155864014125 ATP binding site [chemical binding]; other site 155864014126 Walker B motif; other site 155864014127 arginine finger; other site 155864014128 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 155864014129 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 155864014130 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 155864014131 putative active site [active] 155864014132 heme pocket [chemical binding]; other site 155864014133 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 155864014134 dimer interface [polypeptide binding]; other site 155864014135 phosphorylation site [posttranslational modification] 155864014136 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 155864014137 ATP binding site [chemical binding]; other site 155864014138 Mg2+ binding site [ion binding]; other site 155864014139 G-X-G motif; other site 155864014140 glutamine synthetase; Provisional; Region: glnA; PRK09469 155864014141 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 155864014142 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 155864014143 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 155864014144 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 155864014145 G1 box; other site 155864014146 putative GEF interaction site [polypeptide binding]; other site 155864014147 GTP/Mg2+ binding site [chemical binding]; other site 155864014148 Switch I region; other site 155864014149 G2 box; other site 155864014150 G3 box; other site 155864014151 Switch II region; other site 155864014152 G4 box; other site 155864014153 G5 box; other site 155864014154 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 155864014155 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 155864014156 transcriptional regulator protein; Region: phnR; TIGR03337 155864014157 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 155864014158 DNA-binding site [nucleotide binding]; DNA binding site 155864014159 UTRA domain; Region: UTRA; pfam07702 155864014160 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 155864014161 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864014162 putative substrate translocation pore; other site 155864014163 Major Facilitator Superfamily; Region: MFS_1; pfam07690 155864014164 outer membrane porin L; Provisional; Region: ompL; PRK09980 155864014165 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 155864014166 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864014167 putative substrate translocation pore; other site 155864014168 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 155864014169 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 155864014170 alpha-glucosidase; Provisional; Region: PRK10426 155864014171 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 155864014172 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 155864014173 putative active site [active] 155864014174 putative catalytic site [active] 155864014175 O-island #157; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864014176 O-island #157; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864014177 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 155864014178 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 155864014179 active site 155864014180 catalytic residues [active] 155864014181 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 155864014182 dimerization interface [polypeptide binding]; other site 155864014183 putative active cleft [active] 155864014184 Tagatose-1,6-bisphosphate aldolase [Carbohydrate transport and metabolism]; Region: LacD; COG3684 155864014185 catalytic residue [active] 155864014186 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 155864014187 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 155864014188 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 155864014189 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 155864014190 substrate binding site [chemical binding]; other site 155864014191 ATP binding site [chemical binding]; other site 155864014192 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 155864014193 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 155864014194 putative DNA binding site [nucleotide binding]; other site 155864014195 putative Zn2+ binding site [ion binding]; other site 155864014196 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 155864014197 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 155864014198 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 155864014199 motif II; other site 155864014200 hypothetical protein; Reviewed; Region: PRK01637 155864014201 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 155864014202 putative active site [active] 155864014203 dimerization interface [polypeptide binding]; other site 155864014204 putative tRNAtyr binding site [nucleotide binding]; other site 155864014205 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 155864014206 Coenzyme A binding pocket [chemical binding]; other site 155864014207 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 155864014208 O-island #158; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864014209 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 155864014210 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 155864014211 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 155864014212 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 155864014213 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 155864014214 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 155864014215 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 155864014216 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 155864014217 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 155864014218 [4Fe-4S] binding site [ion binding]; other site 155864014219 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 155864014220 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 155864014221 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 155864014222 molybdopterin cofactor binding site; other site 155864014223 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 155864014224 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 155864014225 putative frv operon regulatory protein; Provisional; Region: PRK09863 155864014226 HTH domain; Region: HTH_11; pfam08279 155864014227 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 155864014228 active site 155864014229 phosphorylation site [posttranslational modification] 155864014230 putative peptidase; Provisional; Region: PRK09864 155864014231 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 155864014232 oligomer interface [polypeptide binding]; other site 155864014233 active site 155864014234 metal binding site [ion binding]; metal-binding site 155864014235 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 155864014236 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 155864014237 active site 155864014238 P-loop; other site 155864014239 phosphorylation site [posttranslational modification] 155864014240 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 155864014241 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 155864014242 active site 155864014243 phosphorylation site [posttranslational modification] 155864014244 O-island #159; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864014245 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 155864014246 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 155864014247 intersubunit interface [polypeptide binding]; other site 155864014248 active site 155864014249 Zn2+ binding site [ion binding]; other site 155864014250 L-rhamnose isomerase; Provisional; Region: PRK01076 155864014251 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 155864014252 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 155864014253 N- and C-terminal domain interface [polypeptide binding]; other site 155864014254 active site 155864014255 putative catalytic site [active] 155864014256 metal binding site [ion binding]; metal-binding site 155864014257 ATP binding site [chemical binding]; other site 155864014258 rhamnulokinase; Provisional; Region: rhaB; PRK10640 155864014259 carbohydrate binding site [chemical binding]; other site 155864014260 transcriptional activator RhaS; Provisional; Region: PRK13503 155864014261 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 155864014262 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 155864014263 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 155864014264 transcriptional activator RhaR; Provisional; Region: PRK13500 155864014265 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 155864014266 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 155864014267 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 155864014268 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 155864014269 superoxide dismutase; Provisional; Region: PRK10925 155864014270 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 155864014271 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 155864014272 2-keto-3-deoxygluconate transporter; Region: kdgT; TIGR00793 155864014273 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 155864014274 MOSC domain; Region: MOSC; pfam03473 155864014275 3-alpha domain; Region: 3-alpha; pfam03475 155864014276 two-component sensor protein; Provisional; Region: cpxA; PRK09470 155864014277 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 155864014278 dimerization interface [polypeptide binding]; other site 155864014279 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 155864014280 dimer interface [polypeptide binding]; other site 155864014281 phosphorylation site [posttranslational modification] 155864014282 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 155864014283 ATP binding site [chemical binding]; other site 155864014284 Mg2+ binding site [ion binding]; other site 155864014285 G-X-G motif; other site 155864014286 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 155864014287 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 155864014288 active site 155864014289 intermolecular recognition site; other site 155864014290 dimerization interface [polypeptide binding]; other site 155864014291 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 155864014292 DNA binding site [nucleotide binding] 155864014293 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 155864014294 dimer interface [polypeptide binding]; other site 155864014295 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 155864014296 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 155864014297 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 155864014298 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 155864014299 active site 155864014300 ADP/pyrophosphate binding site [chemical binding]; other site 155864014301 dimerization interface [polypeptide binding]; other site 155864014302 allosteric effector site; other site 155864014303 fructose-1,6-bisphosphate binding site; other site 155864014304 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 155864014305 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 155864014306 substrate binding pocket [chemical binding]; other site 155864014307 membrane-bound complex binding site; other site 155864014308 hinge residues; other site 155864014309 CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672 155864014310 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 155864014311 triosephosphate isomerase; Provisional; Region: PRK14567 155864014312 substrate binding site [chemical binding]; other site 155864014313 dimer interface [polypeptide binding]; other site 155864014314 catalytic triad [active] 155864014315 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 155864014316 Predicted membrane protein [Function unknown]; Region: COG3152 155864014317 hypothetical protein; Provisional; Region: PRK09981 155864014318 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 155864014319 Ligand Binding Site [chemical binding]; other site 155864014320 ferredoxin-NADP reductase; Provisional; Region: PRK10926 155864014321 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 155864014322 FAD binding pocket [chemical binding]; other site 155864014323 FAD binding motif [chemical binding]; other site 155864014324 phosphate binding motif [ion binding]; other site 155864014325 beta-alpha-beta structure motif; other site 155864014326 NAD binding pocket [chemical binding]; other site 155864014327 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 155864014328 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 155864014329 putative active site [active] 155864014330 O-island #160; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864014331 glycerol kinase; Provisional; Region: glpK; PRK00047 155864014332 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 155864014333 N- and C-terminal domain interface [polypeptide binding]; other site 155864014334 active site 155864014335 MgATP binding site [chemical binding]; other site 155864014336 catalytic site [active] 155864014337 metal binding site [ion binding]; metal-binding site 155864014338 glycerol binding site [chemical binding]; other site 155864014339 homotetramer interface [polypeptide binding]; other site 155864014340 homodimer interface [polypeptide binding]; other site 155864014341 FBP binding site [chemical binding]; other site 155864014342 protein IIAGlc interface [polypeptide binding]; other site 155864014343 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 155864014344 amphipathic channel; other site 155864014345 Asn-Pro-Ala signature motifs; other site 155864014346 septal ring assembly protein ZapB; Provisional; Region: PRK15422 155864014347 O-island #161; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864014348 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 155864014349 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 155864014350 UbiA prenyltransferase family; Region: UbiA; pfam01040 155864014351 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 155864014352 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 155864014353 Walker A motif; other site 155864014354 ATP binding site [chemical binding]; other site 155864014355 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 155864014356 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 155864014357 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 155864014358 active site 155864014359 HslU subunit interaction site [polypeptide binding]; other site 155864014360 essential cell division protein FtsN; Provisional; Region: PRK10927 155864014361 cell division protein FtsN; Provisional; Region: PRK12757 155864014362 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 155864014363 DNA binding site [nucleotide binding] 155864014364 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 155864014365 domain linker motif; other site 155864014366 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 155864014367 dimerization interface [polypeptide binding]; other site 155864014368 ligand binding site [chemical binding]; other site 155864014369 primosome assembly protein PriA; Validated; Region: PRK05580 155864014370 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 155864014371 ATP binding site [chemical binding]; other site 155864014372 putative Mg++ binding site [ion binding]; other site 155864014373 helicase superfamily c-terminal domain; Region: HELICc; smart00490 155864014374 ATP-binding site [chemical binding]; other site 155864014375 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 155864014376 O-island #162; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864014377 PAAR motif; Region: PAAR_motif; cl15808 155864014378 RHS Repeat; Region: RHS_repeat; pfam05593 155864014379 RHS Repeat; Region: RHS_repeat; pfam05593 155864014380 RHS Repeat; Region: RHS_repeat; pfam05593 155864014381 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 155864014382 RHS Repeat; Region: RHS_repeat; pfam05593 155864014383 RHS Repeat; Region: RHS_repeat; pfam05593 155864014384 RHS protein; Region: RHS; pfam03527 155864014385 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 155864014386 Domain of unknown function (DUF4329); Region: DUF4329; pfam14220 155864014387 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 155864014388 O-island #162; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864014389 hypothetical protein; Provisional; Region: PRK10030 155864014390 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 155864014391 dimerization interface [polypeptide binding]; other site 155864014392 DNA binding site [nucleotide binding] 155864014393 corepressor binding sites; other site 155864014394 cystathionine gamma-synthase; Provisional; Region: PRK08045 155864014395 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 155864014396 homodimer interface [polypeptide binding]; other site 155864014397 substrate-cofactor binding pocket; other site 155864014398 pyridoxal 5'-phosphate binding site [chemical binding]; other site 155864014399 catalytic residue [active] 155864014400 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 155864014401 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 155864014402 putative catalytic residues [active] 155864014403 putative nucleotide binding site [chemical binding]; other site 155864014404 putative aspartate binding site [chemical binding]; other site 155864014405 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 155864014406 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 155864014407 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 155864014408 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 155864014409 FAD binding site [chemical binding]; other site 155864014410 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 155864014411 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 155864014412 heme binding site [chemical binding]; other site 155864014413 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 155864014414 EamA-like transporter family; Region: EamA; pfam00892 155864014415 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 155864014416 EamA-like transporter family; Region: EamA; pfam00892 155864014417 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738 155864014418 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 155864014419 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 155864014420 dimer interface [polypeptide binding]; other site 155864014421 active site 155864014422 metal binding site [ion binding]; metal-binding site 155864014423 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 155864014424 active site 155864014425 intersubunit interactions; other site 155864014426 catalytic residue [active] 155864014427 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 155864014428 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 155864014429 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 155864014430 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 155864014431 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 155864014432 active site 155864014433 phosphorylation site [posttranslational modification] 155864014434 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 155864014435 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 155864014436 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 155864014437 active site 155864014438 P-loop; other site 155864014439 phosphorylation site [posttranslational modification] 155864014440 putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983 155864014441 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 155864014442 dimer interface [polypeptide binding]; other site 155864014443 active site 155864014444 glycine loop; other site 155864014445 pyruvate formate lyase II activase; Provisional; Region: PRK10076 155864014446 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 155864014447 active site 155864014448 P-loop; other site 155864014449 phosphorylation site [posttranslational modification] 155864014450 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 155864014451 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 155864014452 hypothetical protein; Provisional; Region: PRK10649 155864014453 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 155864014454 Sulfatase; Region: Sulfatase; pfam00884 155864014455 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 155864014456 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 155864014457 acetylornithine deacetylase; Provisional; Region: PRK05111 155864014458 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 155864014459 metal binding site [ion binding]; metal-binding site 155864014460 putative dimer interface [polypeptide binding]; other site 155864014461 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 155864014462 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 155864014463 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 155864014464 nucleotide binding site [chemical binding]; other site 155864014465 N-acetyl-L-glutamate binding site [chemical binding]; other site 155864014466 argininosuccinate lyase; Provisional; Region: PRK04833 155864014467 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 155864014468 active sites [active] 155864014469 tetramer interface [polypeptide binding]; other site 155864014470 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 155864014471 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 155864014472 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 155864014473 dimerization interface [polypeptide binding]; other site 155864014474 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 155864014475 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 155864014476 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 155864014477 O-island #163; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864014478 O-island #163; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864014479 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 155864014480 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 155864014481 metal binding site [ion binding]; metal-binding site 155864014482 putative dimer interface [polypeptide binding]; other site 155864014483 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864014484 metabolite-proton symporter; Region: 2A0106; TIGR00883 155864014485 putative substrate translocation pore; other site 155864014486 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 155864014487 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 155864014488 hypothetical protein; Provisional; Region: PRK11056 155864014489 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 155864014490 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 155864014491 S-adenosylmethionine binding site [chemical binding]; other site 155864014492 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 155864014493 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 155864014494 N-terminal plug; other site 155864014495 ligand-binding site [chemical binding]; other site 155864014496 glutamate racemase; Provisional; Region: PRK00865 155864014497 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 155864014498 FAD binding domain; Region: FAD_binding_4; pfam01565 155864014499 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 155864014500 Biotin operon repressor [Transcription]; Region: BirA; COG1654 155864014501 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 155864014502 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 155864014503 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 155864014504 pantothenate kinase; Provisional; Region: PRK05439 155864014505 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 155864014506 ATP-binding site [chemical binding]; other site 155864014507 CoA-binding site [chemical binding]; other site 155864014508 Mg2+-binding site [ion binding]; other site 155864014509 elongation factor Tu; Reviewed; Region: PRK00049 155864014510 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 155864014511 G1 box; other site 155864014512 GEF interaction site [polypeptide binding]; other site 155864014513 GTP/Mg2+ binding site [chemical binding]; other site 155864014514 Switch I region; other site 155864014515 G2 box; other site 155864014516 G3 box; other site 155864014517 Switch II region; other site 155864014518 G4 box; other site 155864014519 G5 box; other site 155864014520 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 155864014521 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 155864014522 Antibiotic Binding Site [chemical binding]; other site 155864014523 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 155864014524 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 155864014525 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 155864014526 putative homodimer interface [polypeptide binding]; other site 155864014527 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 155864014528 heterodimer interface [polypeptide binding]; other site 155864014529 homodimer interface [polypeptide binding]; other site 155864014530 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 155864014531 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 155864014532 23S rRNA interface [nucleotide binding]; other site 155864014533 L7/L12 interface [polypeptide binding]; other site 155864014534 putative thiostrepton binding site; other site 155864014535 L25 interface [polypeptide binding]; other site 155864014536 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 155864014537 mRNA/rRNA interface [nucleotide binding]; other site 155864014538 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 155864014539 23S rRNA interface [nucleotide binding]; other site 155864014540 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 155864014541 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 155864014542 core dimer interface [polypeptide binding]; other site 155864014543 peripheral dimer interface [polypeptide binding]; other site 155864014544 L10 interface [polypeptide binding]; other site 155864014545 L11 interface [polypeptide binding]; other site 155864014546 putative EF-Tu interaction site [polypeptide binding]; other site 155864014547 putative EF-G interaction site [polypeptide binding]; other site 155864014548 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 155864014549 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 155864014550 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 155864014551 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 155864014552 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 155864014553 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 155864014554 RPB3 interaction site [polypeptide binding]; other site 155864014555 RPB1 interaction site [polypeptide binding]; other site 155864014556 RPB11 interaction site [polypeptide binding]; other site 155864014557 RPB10 interaction site [polypeptide binding]; other site 155864014558 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 155864014559 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 155864014560 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 155864014561 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 155864014562 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 155864014563 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 155864014564 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 155864014565 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 155864014566 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 155864014567 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 155864014568 DNA binding site [nucleotide binding] 155864014569 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 155864014570 stationary phase growth adaptation protein; Provisional; Region: PRK09717 155864014571 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 155864014572 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 155864014573 FeS/SAM binding site; other site 155864014574 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 155864014575 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 155864014576 ThiS interaction site; other site 155864014577 putative active site [active] 155864014578 tetramer interface [polypeptide binding]; other site 155864014579 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 155864014580 thiS-thiF/thiG interaction site; other site 155864014581 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 155864014582 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 155864014583 ATP binding site [chemical binding]; other site 155864014584 substrate interface [chemical binding]; other site 155864014585 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 155864014586 thiamine phosphate binding site [chemical binding]; other site 155864014587 active site 155864014588 pyrophosphate binding site [ion binding]; other site 155864014589 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 155864014590 ThiC-associated domain; Region: ThiC-associated; pfam13667 155864014591 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 155864014592 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 155864014593 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 155864014594 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 155864014595 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 155864014596 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 155864014597 putative NADH binding site [chemical binding]; other site 155864014598 putative active site [active] 155864014599 nudix motif; other site 155864014600 putative metal binding site [ion binding]; other site 155864014601 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 155864014602 substrate binding site [chemical binding]; other site 155864014603 active site 155864014604 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 155864014605 Active_site [active] 155864014606 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 155864014607 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 155864014608 IHF dimer interface [polypeptide binding]; other site 155864014609 IHF - DNA interface [nucleotide binding]; other site 155864014610 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 155864014611 zinc resistance protein; Provisional; Region: zraP; PRK11546 155864014612 dimer interface [polypeptide binding]; other site 155864014613 sensor protein ZraS; Provisional; Region: PRK10364 155864014614 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 155864014615 dimer interface [polypeptide binding]; other site 155864014616 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 155864014617 ATP binding site [chemical binding]; other site 155864014618 Mg2+ binding site [ion binding]; other site 155864014619 G-X-G motif; other site 155864014620 O-island #164; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864014621 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 155864014622 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 155864014623 active site 155864014624 phosphorylation site [posttranslational modification] 155864014625 intermolecular recognition site; other site 155864014626 dimerization interface [polypeptide binding]; other site 155864014627 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 155864014628 Walker A motif; other site 155864014629 ATP binding site [chemical binding]; other site 155864014630 Walker B motif; other site 155864014631 arginine finger; other site 155864014632 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 155864014633 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 155864014634 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 155864014635 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 155864014636 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 155864014637 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 155864014638 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 155864014639 purine monophosphate binding site [chemical binding]; other site 155864014640 dimer interface [polypeptide binding]; other site 155864014641 putative catalytic residues [active] 155864014642 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 155864014643 O-island #165; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864014644 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 155864014645 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 155864014646 Coenzyme A binding pocket [chemical binding]; other site 155864014647 homoserine O-succinyltransferase; Provisional; Region: PRK05368 155864014648 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 155864014649 proposed active site lysine [active] 155864014650 conserved cys residue [active] 155864014651 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 155864014652 malate synthase A; Region: malate_syn_A; TIGR01344 155864014653 active site 155864014654 isocitrate lyase; Provisional; Region: PRK15063 155864014655 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 155864014656 tetramer interface [polypeptide binding]; other site 155864014657 active site 155864014658 Mg2+/Mn2+ binding site [ion binding]; other site 155864014659 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 155864014660 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 155864014661 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 155864014662 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 155864014663 transcriptional repressor IclR; Provisional; Region: PRK11569 155864014664 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 155864014665 Bacterial transcriptional regulator; Region: IclR; pfam01614 155864014666 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 155864014667 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 155864014668 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 155864014669 substrate binding pocket [chemical binding]; other site 155864014670 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 155864014671 B12 binding site [chemical binding]; other site 155864014672 cobalt ligand [ion binding]; other site 155864014673 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 155864014674 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 155864014675 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 155864014676 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 155864014677 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 155864014678 active site pocket [active] 155864014679 oxyanion hole [active] 155864014680 catalytic triad [active] 155864014681 active site nucleophile [active] 155864014682 O-island #166; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864014683 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 155864014684 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 155864014685 putative NAD(P) binding site [chemical binding]; other site 155864014686 catalytic Zn binding site [ion binding]; other site 155864014687 PTS system, mannose/fructose/sorbose family, IID component; Region: EIID-AGA; TIGR00828 155864014688 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 155864014689 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 155864014690 active site 155864014691 phosphorylation site [posttranslational modification] 155864014692 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 155864014693 active pocket/dimerization site; other site 155864014694 active site 155864014695 phosphorylation site [posttranslational modification] 155864014696 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 155864014697 classical (c) SDRs; Region: SDR_c; cd05233 155864014698 NAD(P) binding site [chemical binding]; other site 155864014699 active site 155864014700 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 155864014701 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 155864014702 putative DNA binding site [nucleotide binding]; other site 155864014703 putative Zn2+ binding site [ion binding]; other site 155864014704 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 155864014705 O-island #166; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864014706 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 155864014707 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 155864014708 RNA binding surface [nucleotide binding]; other site 155864014709 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 155864014710 probable active site [active] 155864014711 hypothetical protein; Provisional; Region: PRK10515 155864014712 aspartate kinase III; Validated; Region: PRK09084 155864014713 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 155864014714 nucleotide binding site [chemical binding]; other site 155864014715 substrate binding site [chemical binding]; other site 155864014716 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 155864014717 lysine allosteric regulatory site; other site 155864014718 dimer interface [polypeptide binding]; other site 155864014719 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 155864014720 dimer interface [polypeptide binding]; other site 155864014721 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 155864014722 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 155864014723 active site 155864014724 dimer interface [polypeptide binding]; other site 155864014725 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 155864014726 dimer interface [polypeptide binding]; other site 155864014727 active site 155864014728 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 155864014729 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 155864014730 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 155864014731 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 155864014732 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 155864014733 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864014734 putative substrate translocation pore; other site 155864014735 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864014736 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 155864014737 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 155864014738 dimer interface [polypeptide binding]; other site 155864014739 conserved gate region; other site 155864014740 putative PBP binding loops; other site 155864014741 ABC-ATPase subunit interface; other site 155864014742 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 155864014743 dimer interface [polypeptide binding]; other site 155864014744 conserved gate region; other site 155864014745 putative PBP binding loops; other site 155864014746 ABC-ATPase subunit interface; other site 155864014747 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 155864014748 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 155864014749 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 155864014750 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 155864014751 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 155864014752 Walker A/P-loop; other site 155864014753 ATP binding site [chemical binding]; other site 155864014754 Q-loop/lid; other site 155864014755 ABC transporter signature motif; other site 155864014756 Walker B; other site 155864014757 D-loop; other site 155864014758 H-loop/switch region; other site 155864014759 TOBE domain; Region: TOBE_2; pfam08402 155864014760 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 155864014761 trimer interface; other site 155864014762 sugar binding site [chemical binding]; other site 155864014763 maltose regulon periplasmic protein; Provisional; Region: PRK10564 155864014764 hypothetical protein; Validated; Region: PRK09718 155864014765 SopA-like central domain; Region: SopA; pfam13981 155864014766 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 155864014767 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 155864014768 UbiA prenyltransferase family; Region: UbiA; pfam01040 155864014769 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 155864014770 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 155864014771 putative acyl-acceptor binding pocket; other site 155864014772 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 155864014773 LexA repressor; Validated; Region: PRK00215 155864014774 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 155864014775 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 155864014776 Catalytic site [active] 155864014777 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 155864014778 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 155864014779 hypothetical protein; Provisional; Region: PRK10428 155864014780 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 155864014781 metal binding site 2 [ion binding]; metal-binding site 155864014782 putative DNA binding helix; other site 155864014783 metal binding site 1 [ion binding]; metal-binding site 155864014784 dimer interface [polypeptide binding]; other site 155864014785 structural Zn2+ binding site [ion binding]; other site 155864014786 Protein of unknown function (DUF2713); Region: DUF2713; pfam10897 155864014787 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 155864014788 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 155864014789 FMN binding site [chemical binding]; other site 155864014790 active site 155864014791 catalytic residues [active] 155864014792 substrate binding site [chemical binding]; other site 155864014793 phage shock protein G; Reviewed; Region: pspG; PRK09459 155864014794 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 155864014795 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 155864014796 NADP binding site [chemical binding]; other site 155864014797 dimer interface [polypeptide binding]; other site 155864014798 replicative DNA helicase; Provisional; Region: PRK08006 155864014799 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 155864014800 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 155864014801 Walker A motif; other site 155864014802 ATP binding site [chemical binding]; other site 155864014803 Walker B motif; other site 155864014804 DNA binding loops [nucleotide binding] 155864014805 alanine racemase; Reviewed; Region: alr; PRK00053 155864014806 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 155864014807 active site 155864014808 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 155864014809 substrate binding site [chemical binding]; other site 155864014810 catalytic residues [active] 155864014811 dimer interface [polypeptide binding]; other site 155864014812 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 155864014813 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 155864014814 pyridoxal 5'-phosphate binding site [chemical binding]; other site 155864014815 homodimer interface [polypeptide binding]; other site 155864014816 catalytic residue [active] 155864014817 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 155864014818 active site 155864014819 motif I; other site 155864014820 motif II; other site 155864014821 secondary thiamine-phosphate synthase enzyme; Region: TIGR00149_YjbQ 155864014822 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 155864014823 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 155864014824 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 155864014825 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 155864014826 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 155864014827 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 155864014828 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 155864014829 dimer interface [polypeptide binding]; other site 155864014830 ssDNA binding site [nucleotide binding]; other site 155864014831 tetramer (dimer of dimers) interface [polypeptide binding]; other site 155864014832 putative single-stranded DNA-binding protein; Region: PHA01740 155864014833 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 155864014834 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 155864014835 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 155864014836 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 155864014837 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 155864014838 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 155864014839 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 155864014840 DNA binding residues [nucleotide binding] 155864014841 dimer interface [polypeptide binding]; other site 155864014842 [2Fe-2S] cluster binding site [ion binding]; other site 155864014843 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 155864014844 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 155864014845 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 155864014846 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 155864014847 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 155864014848 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 155864014849 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 155864014850 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 155864014851 Na binding site [ion binding]; other site 155864014852 Predicted membrane protein [Function unknown]; Region: COG3162 155864014853 acetyl-CoA synthetase; Provisional; Region: PRK00174 155864014854 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 155864014855 active site 155864014856 CoA binding site [chemical binding]; other site 155864014857 acyl-activating enzyme (AAE) consensus motif; other site 155864014858 AMP binding site [chemical binding]; other site 155864014859 acetate binding site [chemical binding]; other site 155864014860 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 155864014861 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 155864014862 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 155864014863 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 155864014864 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 155864014865 heme lyase subunit NrfE; Provisional; Region: PRK10369 155864014866 formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144 155864014867 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 155864014868 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 155864014869 binding surface 155864014870 TPR motif; other site 155864014871 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 155864014872 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 155864014873 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 155864014874 Sel1-like repeats; Region: SEL1; smart00671 155864014875 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 155864014876 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 155864014877 [4Fe-4S] binding site [ion binding]; other site 155864014878 molybdopterin cofactor binding site; other site 155864014879 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 155864014880 molybdopterin cofactor binding site; other site 155864014881 putative outer membrane efflux protein MdtP; Provisional; Region: PRK09915 155864014882 multidrug efflux system protein MdtO; Provisional; Region: PRK11427 155864014883 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 155864014884 multidrug resistance protein MdtN; Provisional; Region: PRK10476 155864014885 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 155864014886 HlyD family secretion protein; Region: HlyD_3; pfam13437 155864014887 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 155864014888 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 155864014889 O-island #167; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864014890 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 155864014891 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 155864014892 active site 155864014893 phosphorylation site [posttranslational modification] 155864014894 intermolecular recognition site; other site 155864014895 dimerization interface [polypeptide binding]; other site 155864014896 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 155864014897 DNA binding site [nucleotide binding] 155864014898 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 155864014899 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 155864014900 substrate binding site [chemical binding]; other site 155864014901 ATP binding site [chemical binding]; other site 155864014902 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 155864014903 intersubunit interface [polypeptide binding]; other site 155864014904 active site 155864014905 zinc binding site [ion binding]; other site 155864014906 Na+ binding site [ion binding]; other site 155864014907 Protein of unknown function (DUF1498); Region: DUF1498; pfam07385 155864014908 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 155864014909 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 155864014910 putative ligand binding site [chemical binding]; other site 155864014911 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 155864014912 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 155864014913 TM-ABC transporter signature motif; other site 155864014914 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 155864014915 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 155864014916 Walker A/P-loop; other site 155864014917 ATP binding site [chemical binding]; other site 155864014918 Q-loop/lid; other site 155864014919 ABC transporter signature motif; other site 155864014920 Walker B; other site 155864014921 D-loop; other site 155864014922 H-loop/switch region; other site 155864014923 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 155864014924 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 155864014925 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 155864014926 dimerization interface [polypeptide binding]; other site 155864014927 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 155864014928 dimer interface [polypeptide binding]; other site 155864014929 phosphorylation site [posttranslational modification] 155864014930 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 155864014931 ATP binding site [chemical binding]; other site 155864014932 Mg2+ binding site [ion binding]; other site 155864014933 G-X-G motif; other site 155864014934 Response regulator receiver domain; Region: Response_reg; pfam00072 155864014935 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 155864014936 active site 155864014937 phosphorylation site [posttranslational modification] 155864014938 intermolecular recognition site; other site 155864014939 dimerization interface [polypeptide binding]; other site 155864014940 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 155864014941 putative hydrolase; Provisional; Region: PRK02113 155864014942 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 155864014943 Coenzyme A binding pocket [chemical binding]; other site 155864014944 ribose 1,5-bisphosphokinase; Provisional; Region: PRK10078 155864014945 AAA domain; Region: AAA_18; pfam13238 155864014946 active site 155864014947 Metal-dependent hydrolase involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3454 155864014948 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 155864014949 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 155864014950 active site 155864014951 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 155864014952 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 155864014953 Walker A/P-loop; other site 155864014954 ATP binding site [chemical binding]; other site 155864014955 Q-loop/lid; other site 155864014956 ABC transporter signature motif; other site 155864014957 Walker B; other site 155864014958 D-loop; other site 155864014959 H-loop/switch region; other site 155864014960 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 155864014961 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 155864014962 Walker A/P-loop; other site 155864014963 ATP binding site [chemical binding]; other site 155864014964 Q-loop/lid; other site 155864014965 ABC transporter signature motif; other site 155864014966 Walker B; other site 155864014967 D-loop; other site 155864014968 H-loop/switch region; other site 155864014969 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 155864014970 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 155864014971 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnI; COG3626 155864014972 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnH; COG3625 155864014973 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 155864014974 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 155864014975 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 155864014976 DNA-binding site [nucleotide binding]; DNA binding site 155864014977 UTRA domain; Region: UTRA; pfam07702 155864014978 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 155864014979 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 155864014980 dimer interface [polypeptide binding]; other site 155864014981 conserved gate region; other site 155864014982 putative PBP binding loops; other site 155864014983 ABC-ATPase subunit interface; other site 155864014984 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 155864014985 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 155864014986 substrate binding pocket [chemical binding]; other site 155864014987 membrane-bound complex binding site; other site 155864014988 hinge residues; other site 155864014989 phosphonate/organophosphate ester transporter subunit; Provisional; Region: PRK09984 155864014990 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 155864014991 Walker A/P-loop; other site 155864014992 ATP binding site [chemical binding]; other site 155864014993 Q-loop/lid; other site 155864014994 ABC transporter signature motif; other site 155864014995 Walker B; other site 155864014996 D-loop; other site 155864014997 H-loop/switch region; other site 155864014998 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 155864014999 dimer interface [polypeptide binding]; other site 155864015000 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 155864015001 hypothetical protein; Provisional; Region: PRK10220 155864015002 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 155864015003 PhnA protein; Region: PhnA; pfam03831 155864015004 hypothetical protein; Provisional; Region: PRK09866 155864015005 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 155864015006 G1 box; other site 155864015007 GTP/Mg2+ binding site [chemical binding]; other site 155864015008 G2 box; other site 155864015009 Switch I region; other site 155864015010 G3 box; other site 155864015011 Switch II region; other site 155864015012 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 155864015013 G2 box; other site 155864015014 Switch I region; other site 155864015015 G3 box; other site 155864015016 Switch II region; other site 155864015017 G4 box; other site 155864015018 G5 box; other site 155864015019 YjcZ-like protein; Region: YjcZ; pfam13990 155864015020 proline/glycine betaine transporter; Provisional; Region: PRK10642 155864015021 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864015022 putative substrate translocation pore; other site 155864015023 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 155864015024 sensor protein BasS/PmrB; Provisional; Region: PRK10755 155864015025 HAMP domain; Region: HAMP; pfam00672 155864015026 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 155864015027 dimer interface [polypeptide binding]; other site 155864015028 phosphorylation site [posttranslational modification] 155864015029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 155864015030 ATP binding site [chemical binding]; other site 155864015031 Mg2+ binding site [ion binding]; other site 155864015032 G-X-G motif; other site 155864015033 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 155864015034 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 155864015035 active site 155864015036 phosphorylation site [posttranslational modification] 155864015037 intermolecular recognition site; other site 155864015038 dimerization interface [polypeptide binding]; other site 155864015039 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 155864015040 DNA binding site [nucleotide binding] 155864015041 putative metal dependent hydrolase; Provisional; Region: PRK11598 155864015042 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 155864015043 Sulfatase; Region: Sulfatase; pfam00884 155864015044 arginine:agmatin antiporter; Provisional; Region: PRK10644 155864015045 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 155864015046 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 155864015047 arginine decarboxylase; Provisional; Region: PRK15029 155864015048 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 155864015049 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 155864015050 homodimer interface [polypeptide binding]; other site 155864015051 pyridoxal 5'-phosphate binding site [chemical binding]; other site 155864015052 catalytic residue [active] 155864015053 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 155864015054 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 155864015055 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 155864015056 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 155864015057 alpha-galactosidase; Provisional; Region: PRK15076 155864015058 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 155864015059 NAD binding site [chemical binding]; other site 155864015060 sugar binding site [chemical binding]; other site 155864015061 divalent metal binding site [ion binding]; other site 155864015062 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 155864015063 dimer interface [polypeptide binding]; other site 155864015064 melibiose:sodium symporter; Provisional; Region: PRK10429 155864015065 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 155864015066 hypothetical protein; Provisional; Region: PRK09867 155864015067 fumarate hydratase; Provisional; Region: PRK15389 155864015068 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 155864015069 Fumarase C-terminus; Region: Fumerase_C; pfam05683 155864015070 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 155864015071 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 155864015072 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 155864015073 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 155864015074 active site 155864015075 phosphorylation site [posttranslational modification] 155864015076 intermolecular recognition site; other site 155864015077 dimerization interface [polypeptide binding]; other site 155864015078 Transcriptional regulator; Region: CitT; pfam12431 155864015079 sensory histidine kinase DcuS; Provisional; Region: PRK11086 155864015080 PAS domain; Region: PAS; smart00091 155864015081 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 155864015082 ATP binding site [chemical binding]; other site 155864015083 Mg2+ binding site [ion binding]; other site 155864015084 G-X-G motif; other site 155864015085 Uncharacterized conserved protein [Function unknown]; Region: COG3592 155864015086 Predicted acetyltransferase [General function prediction only]; Region: COG2388 155864015087 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 155864015088 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 155864015089 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 155864015090 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 155864015091 dimer interface [polypeptide binding]; other site 155864015092 putative anticodon binding site; other site 155864015093 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 155864015094 motif 1; other site 155864015095 active site 155864015096 motif 2; other site 155864015097 motif 3; other site 155864015098 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 155864015099 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864015100 putative substrate translocation pore; other site 155864015101 POT family; Region: PTR2; pfam00854 155864015102 lysine decarboxylase CadA; Provisional; Region: PRK15400 155864015103 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 155864015104 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 155864015105 homodimer interface [polypeptide binding]; other site 155864015106 pyridoxal 5'-phosphate binding site [chemical binding]; other site 155864015107 catalytic residue [active] 155864015108 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 155864015109 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 155864015110 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 155864015111 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 155864015112 DNA binding site [nucleotide binding] 155864015113 putative transcriptional regulator; Provisional; Region: PRK11640 155864015114 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 155864015115 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 155864015116 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 155864015117 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 155864015118 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 155864015119 DsbD alpha interface [polypeptide binding]; other site 155864015120 catalytic residues [active] 155864015121 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 155864015122 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 155864015123 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 155864015124 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 155864015125 Aspartase; Region: Aspartase; cd01357 155864015126 active sites [active] 155864015127 tetramer interface [polypeptide binding]; other site 155864015128 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 155864015129 putative transporter; Provisional; Region: PRK11021 155864015130 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 155864015131 oligomerisation interface [polypeptide binding]; other site 155864015132 mobile loop; other site 155864015133 roof hairpin; other site 155864015134 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 155864015135 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 155864015136 ring oligomerisation interface [polypeptide binding]; other site 155864015137 ATP/Mg binding site [chemical binding]; other site 155864015138 stacking interactions; other site 155864015139 hinge regions; other site 155864015140 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 155864015141 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 155864015142 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 155864015143 FeS/SAM binding site; other site 155864015144 elongation factor P; Validated; Region: PRK00529 155864015145 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 155864015146 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 155864015147 RNA binding site [nucleotide binding]; other site 155864015148 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 155864015149 RNA binding site [nucleotide binding]; other site 155864015150 entericidin A; Provisional; Region: PRK09810 155864015151 entericidin B membrane lipoprotein; Provisional; Region: PRK10081 155864015152 multidrug efflux system protein; Provisional; Region: PRK11431 155864015153 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 155864015154 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 155864015155 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 155864015156 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 155864015157 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 155864015158 Iron-sulfur protein interface; other site 155864015159 proximal quinone binding site [chemical binding]; other site 155864015160 C-subunit interface; other site 155864015161 distal quinone binding site; other site 155864015162 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 155864015163 D-subunit interface [polypeptide binding]; other site 155864015164 Iron-sulfur protein interface; other site 155864015165 proximal quinone binding site [chemical binding]; other site 155864015166 distal quinone binding site [chemical binding]; other site 155864015167 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 155864015168 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 155864015169 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 155864015170 L-aspartate oxidase; Provisional; Region: PRK06175 155864015171 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 155864015172 poxB regulator PoxA; Provisional; Region: PRK09350 155864015173 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 155864015174 motif 1; other site 155864015175 dimer interface [polypeptide binding]; other site 155864015176 active site 155864015177 motif 2; other site 155864015178 motif 3; other site 155864015179 inner membrane transporter YjeM; Provisional; Region: PRK15238 155864015180 O-island #168; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864015181 putative mechanosensitive channel protein; Provisional; Region: PRK10929 155864015182 linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated...; Region: H15; cl00073 155864015183 DNA-binding site [nucleotide binding]; DNA binding site 155864015184 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 155864015185 Mechanosensitive ion channel; Region: MS_channel; pfam00924 155864015186 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 155864015187 GTPase RsgA; Reviewed; Region: PRK12288 155864015188 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 155864015189 RNA binding site [nucleotide binding]; other site 155864015190 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 155864015191 GTPase/Zn-binding domain interface [polypeptide binding]; other site 155864015192 GTP/Mg2+ binding site [chemical binding]; other site 155864015193 G4 box; other site 155864015194 G5 box; other site 155864015195 G1 box; other site 155864015196 Switch I region; other site 155864015197 G2 box; other site 155864015198 G3 box; other site 155864015199 Switch II region; other site 155864015200 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 155864015201 catalytic site [active] 155864015202 putative active site [active] 155864015203 putative substrate binding site [chemical binding]; other site 155864015204 dimer interface [polypeptide binding]; other site 155864015205 epoxyqueuosine reductase; Region: TIGR00276 155864015206 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 155864015207 putative carbohydrate kinase; Provisional; Region: PRK10565 155864015208 yjeF N-terminal region; Region: yjeF_nterm; TIGR00197 155864015209 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 155864015210 putative substrate binding site [chemical binding]; other site 155864015211 putative ATP binding site [chemical binding]; other site 155864015212 ADP-binding protein; Provisional; Region: PRK10646 155864015213 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 155864015214 AMIN domain; Region: AMIN; pfam11741 155864015215 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 155864015216 active site 155864015217 metal binding site [ion binding]; metal-binding site 155864015218 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 155864015219 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 155864015220 ATP binding site [chemical binding]; other site 155864015221 Mg2+ binding site [ion binding]; other site 155864015222 G-X-G motif; other site 155864015223 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 155864015224 ATP binding site [chemical binding]; other site 155864015225 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 155864015226 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 155864015227 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 155864015228 bacterial Hfq-like; Region: Hfq; cd01716 155864015229 hexamer interface [polypeptide binding]; other site 155864015230 Sm1 motif; other site 155864015231 RNA binding site [nucleotide binding]; other site 155864015232 Sm2 motif; other site 155864015233 GTPase HflX; Provisional; Region: PRK11058 155864015234 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 155864015235 HflX GTPase family; Region: HflX; cd01878 155864015236 G1 box; other site 155864015237 GTP/Mg2+ binding site [chemical binding]; other site 155864015238 Switch I region; other site 155864015239 G2 box; other site 155864015240 G3 box; other site 155864015241 Switch II region; other site 155864015242 G4 box; other site 155864015243 G5 box; other site 155864015244 FtsH protease regulator HflK; Provisional; Region: PRK10930 155864015245 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 155864015246 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 155864015247 FtsH protease regulator HflC; Provisional; Region: PRK11029 155864015248 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 155864015249 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 155864015250 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 155864015251 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 155864015252 GDP-binding site [chemical binding]; other site 155864015253 ACT binding site; other site 155864015254 IMP binding site; other site 155864015255 Predicted transcriptional regulator [Transcription]; Region: COG1959 155864015256 transcriptional repressor NsrR; Provisional; Region: PRK11014 155864015257 exoribonuclease R; Provisional; Region: PRK11642 155864015258 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 155864015259 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 155864015260 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 155864015261 RNB domain; Region: RNB; pfam00773 155864015262 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 155864015263 RNA binding site [nucleotide binding]; other site 155864015264 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 155864015265 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 155864015266 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 155864015267 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3789 155864015268 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 155864015269 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 155864015270 Predicted membrane protein [Function unknown]; Region: COG3766 155864015271 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 155864015272 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 155864015273 Predicted integral membrane protein [Function unknown]; Region: COG5463 155864015274 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 155864015275 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 155864015276 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 155864015277 FAD binding site [chemical binding]; other site 155864015278 substrate binding site [chemical binding]; other site 155864015279 catalytic residues [active] 155864015280 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 155864015281 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 155864015282 esterase; Provisional; Region: PRK10566 155864015283 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 155864015284 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 155864015285 transcriptional repressor UlaR; Provisional; Region: PRK13509 155864015286 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 155864015287 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 155864015288 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 155864015289 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 155864015290 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 155864015291 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 155864015292 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 155864015293 active site 155864015294 P-loop; other site 155864015295 phosphorylation site [posttranslational modification] 155864015296 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 155864015297 active site 155864015298 phosphorylation site [posttranslational modification] 155864015299 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 155864015300 active site 155864015301 dimer interface [polypeptide binding]; other site 155864015302 magnesium binding site [ion binding]; other site 155864015303 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 155864015304 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 155864015305 AP (apurinic/apyrimidinic) site pocket; other site 155864015306 DNA interaction; other site 155864015307 Metal-binding active site; metal-binding site 155864015308 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 155864015309 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 155864015310 intersubunit interface [polypeptide binding]; other site 155864015311 active site 155864015312 Zn2+ binding site [ion binding]; other site 155864015313 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 155864015314 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 155864015315 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 155864015316 dimer interface [polypeptide binding]; other site 155864015317 ssDNA binding site [nucleotide binding]; other site 155864015318 tetramer (dimer of dimers) interface [polypeptide binding]; other site 155864015319 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 155864015320 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 155864015321 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 155864015322 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 155864015323 Protein of unknown function (DUF2686); Region: DUF2686; pfam10887 155864015324 O-island #169; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864015325 Transposase IS200 like; Region: Y1_Tnp; pfam01797 155864015326 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 155864015327 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 155864015328 Probable transposase; Region: OrfB_IS605; pfam01385 155864015329 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 155864015330 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 155864015331 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 155864015332 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 155864015333 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 155864015334 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 155864015335 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 155864015336 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 155864015337 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 155864015338 Hemerythrin-like domain; Region: Hr-like; cd12108 155864015339 Fe binding site [ion binding]; other site 155864015340 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 155864015341 EamA-like transporter family; Region: EamA; pfam00892 155864015342 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 155864015343 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 155864015344 NADP binding site [chemical binding]; other site 155864015345 Predicted transcriptional regulators [Transcription]; Region: COG1733 155864015346 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 155864015347 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 155864015348 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 155864015349 active site 155864015350 metal binding site [ion binding]; metal-binding site 155864015351 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 155864015352 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 155864015353 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 155864015354 active site 155864015355 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 155864015356 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 155864015357 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 155864015358 Domain of unknown function DUF21; Region: DUF21; pfam01595 155864015359 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 155864015360 Transporter associated domain; Region: CorC_HlyC; smart01091 155864015361 methionine sulfoxide reductase A; Provisional; Region: PRK00058 155864015362 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 155864015363 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 155864015364 Surface antigen; Region: Bac_surface_Ag; pfam01103 155864015365 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 155864015366 Family of unknown function (DUF490); Region: DUF490; pfam04357 155864015367 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 155864015368 putative active site pocket [active] 155864015369 dimerization interface [polypeptide binding]; other site 155864015370 putative catalytic residue [active] 155864015371 hypothetical protein; Provisional; Region: PRK09719 155864015372 antitoxin ChpS; Provisional; Region: PRK11347 155864015373 toxin ChpB; Provisional; Region: PRK09812 155864015374 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 155864015375 dimer interface [polypeptide binding]; other site 155864015376 substrate binding site [chemical binding]; other site 155864015377 metal binding sites [ion binding]; metal-binding site 155864015378 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 155864015379 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 155864015380 putative ligand binding site [chemical binding]; other site 155864015381 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 155864015382 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 155864015383 Walker A/P-loop; other site 155864015384 ATP binding site [chemical binding]; other site 155864015385 Q-loop/lid; other site 155864015386 ABC transporter signature motif; other site 155864015387 Walker B; other site 155864015388 D-loop; other site 155864015389 H-loop/switch region; other site 155864015390 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 155864015391 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 155864015392 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 155864015393 TM-ABC transporter signature motif; other site 155864015394 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 155864015395 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 155864015396 TM-ABC transporter signature motif; other site 155864015397 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 155864015398 AMP binding site [chemical binding]; other site 155864015399 metal binding site [ion binding]; metal-binding site 155864015400 active site 155864015401 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 155864015402 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 155864015403 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 155864015404 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 155864015405 hypothetical protein; Provisional; Region: PRK05255 155864015406 peptidase PmbA; Provisional; Region: PRK11040 155864015407 Cytochrome b562; Region: Cytochrom_B562; cl01546 155864015408 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 155864015409 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 155864015410 FeS/SAM binding site; other site 155864015411 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 155864015412 ATP cone domain; Region: ATP-cone; pfam03477 155864015413 Class III ribonucleotide reductase; Region: RNR_III; cd01675 155864015414 effector binding site; other site 155864015415 active site 155864015416 Zn binding site [ion binding]; other site 155864015417 glycine loop; other site 155864015418 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 155864015419 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 155864015420 Ca binding site [ion binding]; other site 155864015421 active site 155864015422 catalytic site [active] 155864015423 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 155864015424 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 155864015425 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 155864015426 active site turn [active] 155864015427 phosphorylation site [posttranslational modification] 155864015428 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 155864015429 trehalose repressor; Provisional; Region: treR; PRK09492 155864015430 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 155864015431 DNA binding site [nucleotide binding] 155864015432 domain linker motif; other site 155864015433 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 155864015434 dimerization interface [polypeptide binding]; other site 155864015435 ligand binding site [chemical binding]; other site 155864015436 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 155864015437 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 155864015438 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 155864015439 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 155864015440 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 155864015441 motif II; other site 155864015442 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 155864015443 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 155864015444 homotrimer interaction site [polypeptide binding]; other site 155864015445 putative active site [active] 155864015446 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 155864015447 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 155864015448 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 155864015449 aspartate carbamoyltransferase; Region: asp_carb_tr; TIGR00670 155864015450 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 155864015451 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 155864015452 PyrBI operon leader peptide; Region: PyrBI_leader; pfam08052 155864015453 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 155864015454 homotrimer interaction site [polypeptide binding]; other site 155864015455 putative active site [active] 155864015456 oxidoreductase; Provisional; Region: PRK12742 155864015457 classical (c) SDRs; Region: SDR_c; cd05233 155864015458 NAD(P) binding site [chemical binding]; other site 155864015459 active site 155864015460 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 155864015461 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 155864015462 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 155864015463 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 155864015464 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076 155864015465 RNase E inhibitor protein; Provisional; Region: PRK11191 155864015466 Predicted membrane protein [Function unknown]; Region: COG4269 155864015467 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 155864015468 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 155864015469 HIGH motif; other site 155864015470 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 155864015471 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 155864015472 active site 155864015473 KMSKS motif; other site 155864015474 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 155864015475 tRNA binding surface [nucleotide binding]; other site 155864015476 anticodon binding site; other site 155864015477 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 155864015478 DNA polymerase III subunit chi; Validated; Region: PRK05728 155864015479 O-island #170; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864015480 O-island #170; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864015481 multifunctional aminopeptidase A; Provisional; Region: PRK00913 155864015482 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 155864015483 interface (dimer of trimers) [polypeptide binding]; other site 155864015484 Substrate-binding/catalytic site; other site 155864015485 Zn-binding sites [ion binding]; other site 155864015486 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 155864015487 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 155864015488 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 155864015489 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 155864015490 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 155864015491 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 155864015492 O-island #171; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864015493 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 155864015494 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 155864015495 putative NAD(P) binding site [chemical binding]; other site 155864015496 putative substrate binding site [chemical binding]; other site 155864015497 catalytic Zn binding site [ion binding]; other site 155864015498 structural Zn binding site [ion binding]; other site 155864015499 dimer interface [polypeptide binding]; other site 155864015500 O-island #172; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864015501 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 155864015502 INT_SG2, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 2, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinases and phage-related integrases. Some have N-terminal domains, which show little sequence...; Region: INT_SG2_C; cd01184 155864015503 Int/Topo IB signature motif; other site 155864015504 Transposase; Region: HTH_Tnp_1; cl17663 155864015505 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 155864015506 O-island #172; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864015507 Integrase core domain; Region: rve; pfam00665 155864015508 Integrase core domain; Region: rve_3; pfam13683 155864015509 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 155864015510 NIPSNAP; Region: NIPSNAP; pfam07978 155864015511 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4333 155864015512 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 155864015513 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 155864015514 catalytic residues [active] 155864015515 catalytic nucleophile [active] 155864015516 Presynaptic Site I dimer interface [polypeptide binding]; other site 155864015517 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 155864015518 Synaptic Flat tetramer interface [polypeptide binding]; other site 155864015519 Synaptic Site I dimer interface [polypeptide binding]; other site 155864015520 DNA binding site [nucleotide binding] 155864015521 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 155864015522 DNA-binding interface [nucleotide binding]; DNA binding site 155864015523 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 155864015524 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 155864015525 non-specific DNA binding site [nucleotide binding]; other site 155864015526 salt bridge; other site 155864015527 sequence-specific DNA binding site [nucleotide binding]; other site 155864015528 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 155864015529 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 155864015530 HNH endonuclease; Region: HNH_2; pfam13391 155864015531 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3055 155864015532 O-island #172; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864015533 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 155864015534 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 155864015535 active site 155864015536 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 155864015537 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 155864015538 ligand binding site [chemical binding]; other site 155864015539 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 155864015540 Capsid triplex subunit 2; Provisional; Region: PHA03259 155864015541 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 155864015542 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 155864015543 ATP binding site [chemical binding]; other site 155864015544 putative Mg++ binding site [ion binding]; other site 155864015545 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 155864015546 nucleotide binding region [chemical binding]; other site 155864015547 ATP-binding site [chemical binding]; other site 155864015548 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 155864015549 O-island #172; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864015550 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 155864015551 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 155864015552 ATP binding site [chemical binding]; other site 155864015553 putative Mg++ binding site [ion binding]; other site 155864015554 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 155864015555 nucleotide binding region [chemical binding]; other site 155864015556 ATP-binding site [chemical binding]; other site 155864015557 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 155864015558 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 155864015559 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 155864015560 ATP binding site [chemical binding]; other site 155864015561 putative Mg++ binding site [ion binding]; other site 155864015562 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 155864015563 ATP-binding site [chemical binding]; other site 155864015564 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 155864015565 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 155864015566 Part of AAA domain; Region: AAA_19; pfam13245 155864015567 Family description; Region: UvrD_C_2; pfam13538 155864015568 O-island #172; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864015569 similar to hypothetical protein; No significant matches 155864015570 Domain of unknown function (DUF303); Region: DUF303; pfam03629 155864015571 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 155864015572 Kelch motif; Region: Kelch_1; pfam01344 155864015573 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 155864015574 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 155864015575 Int/Topo IB signature motif; other site 155864015576 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 155864015577 Int/Topo IB signature motif; other site 155864015578 Fimbrial protein; Region: Fimbrial; cl01416 155864015579 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 155864015580 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 155864015581 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 155864015582 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 155864015583 outer membrane usher protein; Provisional; Region: PRK15193 155864015584 PapC N-terminal domain; Region: PapC_N; pfam13954 155864015585 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 155864015586 PapC C-terminal domain; Region: PapC_C; pfam13953 155864015587 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 155864015588 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 155864015589 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 155864015590 mannosyl binding site [chemical binding]; other site 155864015591 Fimbrial protein; Region: Fimbrial; pfam00419 155864015592 fructuronate transporter; Provisional; Region: PRK10034 155864015593 gluconate transporter; Region: gntP; TIGR00791 155864015594 mannonate dehydratase; Region: uxuA; TIGR00695 155864015595 mannonate dehydratase; Provisional; Region: PRK03906 155864015596 D-mannonate oxidoreductase; Provisional; Region: PRK15037 155864015597 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 155864015598 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 155864015599 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 155864015600 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 155864015601 DNA-binding site [nucleotide binding]; DNA binding site 155864015602 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 155864015603 Protein of unknown function (DUF2686); Region: DUF2686; pfam10887 155864015604 DNA replication/recombination/repair protein; Provisional; Region: iraD; PRK14128 155864015605 cell density-dependent motility repressor; Provisional; Region: PRK10082 155864015606 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 155864015607 Isoaspartyl dipeptidase hydrolyzes the beta-L-isoaspartyl linkages in dipeptides, as part of the degradative pathway to eliminate proteins with beta-L-isoaspartyl peptide bonds, bonds whereby the beta-group of an aspartate forms the peptide link with the...; Region: Isoaspartyl-dipeptidase; cd01308 155864015608 isoaspartyl dipeptidase IadA; Region: isoAsp_dipep; TIGR01975 155864015609 dimer interface [polypeptide binding]; other site 155864015610 active site 155864015611 hypothetical protein; Provisional; Region: PRK10519 155864015612 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 155864015613 Nucleoside recognition; Region: Gate; pfam07670 155864015614 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 155864015615 O-island #173; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864015616 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 155864015617 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 155864015618 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 155864015619 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 155864015620 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 155864015621 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 155864015622 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 155864015623 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 155864015624 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 155864015625 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 155864015626 Major Facilitator Superfamily; Region: MFS_1; pfam07690 155864015627 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864015628 putative substrate translocation pore; other site 155864015629 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204 155864015630 SdiA-regulated; Region: SdiA-regulated; cd09971 155864015631 putative active site [active] 155864015632 O-island #174; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864015633 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 155864015634 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 155864015635 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 155864015636 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 155864015637 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 155864015638 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 155864015639 O-island #174; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864015640 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 155864015641 CoA-substrate-specific enzyme activase, putative; Region: CoA_E_activ; TIGR00241 155864015642 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 155864015643 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 155864015644 Predicted membrane protein [Function unknown]; Region: COG2733 155864015645 multidrug efflux system protein MdtM; Provisional; Region: PRK15403 155864015646 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864015647 putative substrate translocation pore; other site 155864015648 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 155864015649 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 155864015650 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 155864015651 DNA-binding site [nucleotide binding]; DNA binding site 155864015652 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 155864015653 pyridoxal 5'-phosphate binding site [chemical binding]; other site 155864015654 homodimer interface [polypeptide binding]; other site 155864015655 catalytic residue [active] 155864015656 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 155864015657 O-island #175; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864015658 Uncharacterized conserved protein [Function unknown]; Region: COG1479 155864015659 Protein of unknown function DUF262; Region: DUF262; pfam03235 155864015660 Protein of unknown function DUF262; Region: DUF262; pfam03235 155864015661 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 155864015662 Uncharacterized conserved protein [Function unknown]; Region: COG3586 155864015663 endoribonuclease SymE; Provisional; Region: PRK13605 155864015664 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 155864015665 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 155864015666 HsdM N-terminal domain; Region: HsdM_N; pfam12161 155864015667 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 155864015668 Methyltransferase domain; Region: Methyltransf_26; pfam13659 155864015669 S-adenosylmethionine binding site [chemical binding]; other site 155864015670 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 155864015671 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 155864015672 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 155864015673 ATP binding site [chemical binding]; other site 155864015674 putative Mg++ binding site [ion binding]; other site 155864015675 Uncharacterized conserved protein [Function unknown]; Region: COG1479 155864015676 Protein of unknown function DUF262; Region: DUF262; pfam03235 155864015677 Uncharacterized conserved protein [Function unknown]; Region: COG1479 155864015678 Protein of unknown function DUF262; Region: DUF262; pfam03235 155864015679 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 155864015680 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 155864015681 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 155864015682 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 155864015683 Uncharacterized small protein [Function unknown]; Region: COG2879 155864015684 carbon starvation protein A; Provisional; Region: PRK15015 155864015685 Carbon starvation protein CstA; Region: CstA; pfam02554 155864015686 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 155864015687 O-island #176; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864015688 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 155864015689 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 155864015690 dimer interface [polypeptide binding]; other site 155864015691 ligand binding site [chemical binding]; other site 155864015692 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 155864015693 dimerization interface [polypeptide binding]; other site 155864015694 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 155864015695 dimer interface [polypeptide binding]; other site 155864015696 putative CheW interface [polypeptide binding]; other site 155864015697 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 155864015698 D-galactonate transporter; Region: 2A0114; TIGR00893 155864015699 putative substrate translocation pore; other site 155864015700 Transcriptional regulators [Transcription]; Region: GntR; COG1802 155864015701 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 155864015702 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 155864015703 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 155864015704 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 155864015705 putative NAD(P) binding site [chemical binding]; other site 155864015706 catalytic Zn binding site [ion binding]; other site 155864015707 structural Zn binding site [ion binding]; other site 155864015708 phosphoglycerol transferase I; Provisional; Region: PRK03776 155864015709 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 155864015710 hypothetical protein; Provisional; Region: PRK11667 155864015711 DNA replication protein DnaC; Validated; Region: PRK07952 155864015712 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 155864015713 Walker A motif; other site 155864015714 ATP binding site [chemical binding]; other site 155864015715 Walker B motif; other site 155864015716 primosomal protein DnaI; Provisional; Region: PRK02854 155864015717 hypothetical protein; Provisional; Region: PRK09917 155864015718 Uncharacterized conserved protein [Function unknown]; Region: COG2966 155864015719 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 155864015720 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 155864015721 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 155864015722 DNA binding residues [nucleotide binding] 155864015723 dimerization interface [polypeptide binding]; other site 155864015724 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 155864015725 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 155864015726 DNA binding residues [nucleotide binding] 155864015727 dimerization interface [polypeptide binding]; other site 155864015728 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 155864015729 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 155864015730 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 155864015731 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 155864015732 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 155864015733 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 155864015734 S-adenosylmethionine binding site [chemical binding]; other site 155864015735 DNA polymerase III subunit psi; Validated; Region: PRK06856 155864015736 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 155864015737 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 155864015738 Coenzyme A binding pocket [chemical binding]; other site 155864015739 dUMP phosphatase; Provisional; Region: PRK09449 155864015740 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 155864015741 motif II; other site 155864015742 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 155864015743 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 155864015744 G1 box; other site 155864015745 putative GEF interaction site [polypeptide binding]; other site 155864015746 GTP/Mg2+ binding site [chemical binding]; other site 155864015747 Switch I region; other site 155864015748 G2 box; other site 155864015749 G3 box; other site 155864015750 Switch II region; other site 155864015751 G4 box; other site 155864015752 G5 box; other site 155864015753 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 155864015754 periplasmic protein; Provisional; Region: PRK10568 155864015755 BON domain; Region: BON; pfam04972 155864015756 BON domain; Region: BON; pfam04972 155864015757 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 155864015758 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 155864015759 active site 155864015760 nucleophile elbow; other site 155864015761 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 155864015762 active site 155864015763 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 155864015764 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 155864015765 FeS/SAM binding site; other site 155864015766 hypothetical protein; Provisional; Region: PRK10977 155864015767 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 155864015768 intersubunit interface [polypeptide binding]; other site 155864015769 active site 155864015770 catalytic residue [active] 155864015771 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 155864015772 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 155864015773 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 155864015774 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 155864015775 phosphopentomutase; Provisional; Region: PRK05362 155864015776 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 155864015777 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 155864015778 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 155864015779 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 155864015780 non-specific DNA binding site [nucleotide binding]; other site 155864015781 salt bridge; other site 155864015782 sequence-specific DNA binding site [nucleotide binding]; other site 155864015783 O-island #177; Region of the EDL933 chromosome not homologous to E. coli K-12 MG1655 155864015784 unknown domain/lipoate-protein ligase A fusion protein; Provisional; Region: PRK14061 155864015785 hypothetical protein; Provisional; Region: PRK11246 155864015786 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 155864015787 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 155864015788 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 155864015789 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 155864015790 motif II; other site 155864015791 DNA repair protein RadA; Region: sms; TIGR00416 155864015792 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 155864015793 Walker A motif/ATP binding site; other site 155864015794 ATP binding site [chemical binding]; other site 155864015795 Walker B motif; other site 155864015796 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 155864015797 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 155864015798 non-specific DNA binding site [nucleotide binding]; other site 155864015799 salt bridge; other site 155864015800 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 155864015801 sequence-specific DNA binding site [nucleotide binding]; other site 155864015802 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 155864015803 active site 155864015804 (T/H)XGH motif; other site 155864015805 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 155864015806 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 155864015807 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 155864015808 Walker A/P-loop; other site 155864015809 ATP binding site [chemical binding]; other site 155864015810 Q-loop/lid; other site 155864015811 ABC transporter signature motif; other site 155864015812 Walker B; other site 155864015813 D-loop; other site 155864015814 H-loop/switch region; other site 155864015815 ABC transporter; Region: ABC_tran_2; pfam12848 155864015816 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 155864015817 lytic murein transglycosylase; Provisional; Region: PRK11619 155864015818 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 155864015819 N-acetyl-D-glucosamine binding site [chemical binding]; other site 155864015820 catalytic residue [active] 155864015821 Trp operon repressor; Provisional; Region: PRK01381 155864015822 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 155864015823 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 155864015824 catalytic core [active] 155864015825 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 155864015826 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 155864015827 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 155864015828 hypothetical protein; Provisional; Region: PRK10756 155864015829 CreA protein; Region: CreA; pfam05981 155864015830 DNA-binding response regulator CreB; Provisional; Region: PRK11083 155864015831 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 155864015832 active site 155864015833 phosphorylation site [posttranslational modification] 155864015834 intermolecular recognition site; other site 155864015835 dimerization interface [polypeptide binding]; other site 155864015836 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 155864015837 DNA binding site [nucleotide binding] 155864015838 sensory histidine kinase CreC; Provisional; Region: PRK11100 155864015839 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 155864015840 dimerization interface [polypeptide binding]; other site 155864015841 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 155864015842 dimer interface [polypeptide binding]; other site 155864015843 phosphorylation site [posttranslational modification] 155864015844 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 155864015845 ATP binding site [chemical binding]; other site 155864015846 Mg2+ binding site [ion binding]; other site 155864015847 G-X-G motif; other site 155864015848 Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452 155864015849 two-component response regulator; Provisional; Region: PRK11173 155864015850 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 155864015851 active site 155864015852 phosphorylation site [posttranslational modification] 155864015853 intermolecular recognition site; other site 155864015854 dimerization interface [polypeptide binding]; other site 155864015855 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 155864015856 DNA binding site [nucleotide binding] 155864015857 putative RNA methyltransferase; Provisional; Region: PRK10433 155864015858 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050 155864015859 conjugal transfer fertility inhibition protein FinO; Provisional; Region: PRK13754 155864015860 Fertility inhibition protein N terminal; Region: FinO_N; pfam12602 155864015861 FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cd00236 155864015862 putative RNA binding sites [nucleotide binding]; other site 155864015863 Staphylococcal nuclease homologues; Region: SNc; smart00318 155864015864 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 155864015865 Catalytic site; other site 155864015866 Haemolysin expression modulating protein; Region: HHA; pfam05321 155864015867 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 155864015868 initiation site; Escherichia coli plasmid R100 ssiB gene; 99 pct identical to ssiB locus R10SSIB accession D90185 155864015869 replication protein; Provisional; Region: PRK13702 155864015870 leader peptide RepL; Provisional; Region: PRK13716 155864015871 replication protein; Provisional; Region: PRK13750 155864015872 88 pct identical to locus ECCIS accession X12587, required for cis-activation of oriR by the replication initation protein 155864015873 dnaA site; 100 pct identical (0 gaps) to locus ECNR1REP at (1682..1690) accession X02302 155864015874 single-strand initiation signal (ssi); 92 pct identical (3 gaps) to the region (200..346) of locus SM3SSI accession M60277, J03327 155864015875 Predicted transcriptional regulator [Transcription]; Region: COG3905 155864015876 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 155864015877 5 bp target duplicated by insertion of Tn801 in pSK3 155864015878 87 pct identical (0 gaps) to 70 residues of an approx. 426 aa protein transposase for IS91 ACCESSION Q47315 155864015879 Integrase core domain; Region: rve; pfam00665 155864015880 Integrase core domain; Region: rve_3; pfam13683 155864015881 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 155864015882 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 155864015883 dimer interface [polypeptide binding]; other site 155864015884 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 155864015885 active site 155864015886 heme binding site [chemical binding]; other site 155864015887 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 155864015888 Cytochrome b562; Region: Cytochrom_B562; pfam07361 155864015889 putative transposase OrfB; Reviewed; Region: PHA02517 155864015890 HTH-like domain; Region: HTH_21; pfam13276 155864015891 Integrase core domain; Region: rve; pfam00665 155864015892 Integrase core domain; Region: rve_3; pfam13683 155864015893 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 155864015894 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 155864015895 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 155864015896 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 155864015897 Autotransporter beta-domain; Region: Autotransporter; pfam03797 155864015898 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 155864015899 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 155864015900 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 155864015901 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 155864015902 Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969 155864015903 putative active site [active] 155864015904 putative metal binding site [ion binding]; other site 155864015905 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 155864015906 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 155864015907 hypothetical protein; Provisional; Region: PRK10649 155864015908 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 155864015909 Sulfatase; Region: Sulfatase; pfam00884 155864015910 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 155864015911 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 155864015912 putative acyl-acceptor binding pocket; other site 155864015913 Peptidase M66; Region: Peptidase_M66; pfam10462 155864015914 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 155864015915 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 155864015916 type II secretion system protein D; Region: type_II_gspD; TIGR02517 155864015917 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 155864015918 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 155864015919 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 155864015920 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 155864015921 type II secretion system protein E; Region: type_II_gspE; TIGR02533 155864015922 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 155864015923 Walker A motif; other site 155864015924 ATP binding site [chemical binding]; other site 155864015925 Walker B motif; other site 155864015926 type II secretion system protein F; Region: GspF; TIGR02120 155864015927 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 155864015928 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 155864015929 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 155864015930 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 155864015931 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 155864015932 type II secretion system protein I; Region: gspI; TIGR01707 155864015933 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 155864015934 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 155864015935 Prokaryotic N-terminal methylation motif; Region: N_methyl; pfam07963 155864015936 type II secretion system protein J; Region: gspJ; TIGR01711 155864015937 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 155864015938 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 155864015939 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 155864015940 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 155864015941 GspL periplasmic domain; Region: GspL_C; pfam12693 155864015942 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 155864015943 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 155864015944 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 155864015945 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 155864015946 lipoprotein, PulS/OutS family; Region: PulS_OutS; TIGR01004 155864015947 97 pct identical and equal length to SDIS911, X17613 155864015948 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 155864015949 Transposase; Region: HTH_Tnp_1; pfam01527 155864015950 putative transposase OrfB; Reviewed; Region: PHA02517 155864015951 HTH-like domain; Region: HTH_21; pfam13276 155864015952 Integrase core domain; Region: rve; pfam00665 155864015953 Integrase core domain; Region: rve_3; pfam13683 155864015954 92 pct identical and equal length to to SDIS911 X17613 155864015955 RTX toxin acyltransferase family; Region: HlyC; pfam02794 155864015956 RTX N-terminal domain; Region: RTX; pfam02382 155864015957 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 155864015958 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 155864015959 RTX C-terminal domain; Region: RTX_C; pfam08339 155864015960 A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine...; Region: Peptidase_C39_likeA; cd02417 155864015961 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 155864015962 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 155864015963 ATP-binding cassette domain of hemolysin B, subfamily C; Region: ABCC_Hemolysin; cd03252 155864015964 Walker A/P-loop; other site 155864015965 ATP binding site [chemical binding]; other site 155864015966 Q-loop/lid; other site 155864015967 ABC transporter signature motif; other site 155864015968 Walker B; other site 155864015969 D-loop; other site 155864015970 H-loop/switch region; other site 155864015971 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 155864015972 HlyD family secretion protein; Region: HlyD_3; pfam13437 155864015973 MarR family; Region: MarR_2; cl17246 155864015974 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 155864015975 DNA binding site [nucleotide binding] 155864015976 active site 155864015977 Int/Topo IB signature motif; other site 155864015978 catalytic residues [active] 155864015979 Initiator Replication protein; Region: Rep_3; cl03080 155864015980 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 155864015981 plasmid maintenance protein CcdA; Provisional; Region: PRK13710 155864015982 plasmid maintenance protein CcdB; Provisional; Region: PRK13708 155864015983 Phage integrase family; Region: Phage_integrase; pfam00589 155864015984 active site 155864015985 DNA binding site [nucleotide binding] 155864015986 Int/Topo IB signature motif; other site 155864015987 putative transposase OrfB; Reviewed; Region: PHA02517 155864015988 HTH-like domain; Region: HTH_21; pfam13276 155864015989 Integrase core domain; Region: rve; pfam00665 155864015990 Integrase core domain; Region: rve_3; pfam13683 155864015991 Transposase; Region: HTH_Tnp_1; cl17663 155864015992 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 155864015993 Initiator Replication protein; Region: Rep_3; cl17676 155864015994 plasmid-partitioning protein SopA; Provisional; Region: PRK13705 155864015995 MerR family regulatory protein; Region: MerR; pfam00376 155864015996 DNA binding residues [nucleotide binding] 155864015997 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 155864015998 P-loop; other site 155864015999 Magnesium ion binding site [ion binding]; other site 155864016000 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 155864016001 Magnesium ion binding site [ion binding]; other site 155864016002 plasmid-partitioning protein; Provisional; Region: PRK13698 155864016003 ParB-like nuclease domain; Region: ParB; smart00470 155864016004 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 155864016005 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 155864016006 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 155864016007 putative active site [active] 155864016008 putative NTP binding site [chemical binding]; other site 155864016009 putative nucleic acid binding site [nucleotide binding]; other site 155864016010 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 155864016011 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 155864016012 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 155864016013 active site 155864016014 Protein of unknown function (DUF1281); Region: DUF1281; pfam06924 155864016015 putative methylase; Provisional; Region: PRK13699 155864016016 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 155864016017 Protein of unknown function (DUF1380); Region: DUF1380; pfam07128 155864016018 Antirestriction protein; Region: Antirestrict; pfam03230 155864016019 Protein of unknown function (DUF1380); Region: DUF1380; pfam07128 155864016020 Domain of unknown function (DUF3560); Region: DUF3560; pfam12083 155864016021 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 155864016022 S-adenosylmethionine binding site [chemical binding]; other site 155864016023 leading region; 98 pct identical to the leading region of F plasmid from E.coli (1..446) ECLEADREG accession X17539 155864016024 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 155864016025 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 155864016026 dimer interface [polypeptide binding]; other site 155864016027 ssDNA binding site [nucleotide binding]; other site 155864016028 tetramer (dimer of dimers) interface [polypeptide binding]; other site 155864016029 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 155864016030 ParB-like nuclease domain; Region: ParBc; pfam02195 155864016031 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 155864016032 KorB domain; Region: KorB; pfam08535 155864016033 plasmid SOS inhibition protein B; Provisional; Region: psiB; PRK13701 155864016034 plasmid SOS inhibition protein A; Provisional; Region: PRK13704 155864016035 modulator of post-segregation killing protein; Provisional; Region: PRK13720 155864016036 small toxic polypeptide; Provisional; Region: PRK09738 155864016037 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 155864016038 TolA C-terminal; Region: TolA; pfam06519 155864016039 Integrase core domain; Region: rve; pfam00665 155864016040 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 155864016041 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402 155864016042 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 155864016043 TcdB toxin N-terminal helical domain; Region: TcdB_N; pfam12918 155864016044 TcdA/TcdB catalytic glycosyltransferase domain; Region: TcdA_TcdB; pfam12919 155864016045 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 155864016046 cysteine protease domain, YopT-type; Region: yopT_cys_prot; TIGR01586 155864016047 Protein of unknown function (DUF3491); Region: DUF3491; pfam11996 155864016048 putative transposase OrfB; Reviewed; Region: PHA02517 155864016049 Transposase; Region: HTH_Tnp_1; cl17663 155864016050 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 155864016051 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 155864016052 DNA helicase TraI; Region: TraI; pfam07057 155864016053 conjugal transfer pilus acetylation protein TraX; Provisional; Region: PRK13706 155864016054 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 155864016055 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 155864016056 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561