-- dump date 20140619_090059 -- class Genbank::misc_feature -- table misc_feature_note -- id note 573235000001 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 573235000002 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 573235000003 putative catalytic residues [active] 573235000004 putative nucleotide binding site [chemical binding]; other site 573235000005 putative aspartate binding site [chemical binding]; other site 573235000006 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 573235000007 dimer interface [polypeptide binding]; other site 573235000008 putative threonine allosteric regulatory site; other site 573235000009 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 573235000010 putative threonine allosteric regulatory site; other site 573235000011 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 573235000012 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 573235000013 homoserine kinase; Region: thrB; TIGR00191 573235000014 Protein of unknown function; Region: YhfT; pfam10797 573235000015 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 573235000016 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 573235000017 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 573235000018 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573235000019 catalytic residue [active] 573235000020 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 573235000021 hypothetical protein; Validated; Region: PRK02101 573235000022 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 573235000023 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 573235000024 transaldolase-like protein; Provisional; Region: PTZ00411 573235000025 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 573235000026 active site 573235000027 dimer interface [polypeptide binding]; other site 573235000028 catalytic residue [active] 573235000029 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 573235000030 MPT binding site; other site 573235000031 trimer interface [polypeptide binding]; other site 573235000032 hypothetical protein; Provisional; Region: PRK10659 573235000033 hypothetical protein; Provisional; Region: PRK10236 573235000034 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 573235000035 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 573235000036 hypothetical protein; Provisional; Region: PRK10154 573235000037 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 573235000038 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 573235000039 nucleotide binding site [chemical binding]; other site 573235000040 NEF interaction site [polypeptide binding]; other site 573235000041 SBD interface [polypeptide binding]; other site 573235000042 chaperone protein DnaJ; Provisional; Region: PRK10767 573235000043 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 573235000044 HSP70 interaction site [polypeptide binding]; other site 573235000045 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 573235000046 substrate binding site [polypeptide binding]; other site 573235000047 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 573235000048 Zn binding sites [ion binding]; other site 573235000049 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 573235000050 dimer interface [polypeptide binding]; other site 573235000051 Hok/gef family; Region: HOK_GEF; pfam01848 573235000052 Hok/gef family; Region: HOK_GEF; pfam01848 573235000053 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 573235000054 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 573235000055 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573235000056 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 573235000057 putative dimerization interface [polypeptide binding]; other site 573235000058 conserved predicted protein, C-terminal part 573235000059 conserved predicted protein (pseudogene by a frame shift mutation) 573235000060 outer membrane usher protein precursor, C-terminal part 573235000061 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 573235000062 Protein of unknown function (DUF2575); Region: DUF2575; pfam10837 573235000063 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 573235000064 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 573235000065 active site 573235000066 Riboflavin kinase; Region: Flavokinase; smart00904 573235000067 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 573235000068 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 573235000069 HIGH motif; other site 573235000070 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 573235000071 active site 573235000072 KMSKS motif; other site 573235000073 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 573235000074 tRNA binding surface [nucleotide binding]; other site 573235000075 anticodon binding site; other site 573235000076 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 573235000077 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 573235000078 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 573235000079 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 573235000080 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 573235000081 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 573235000082 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 573235000083 active site 573235000084 tetramer interface [polypeptide binding]; other site 573235000085 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 573235000086 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 573235000087 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 573235000088 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 573235000089 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 573235000090 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 573235000091 catalytic site [active] 573235000092 subunit interface [polypeptide binding]; other site 573235000093 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 573235000094 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 573235000095 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 573235000096 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 573235000097 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 573235000098 ATP-grasp domain; Region: ATP-grasp_4; cl17255 573235000099 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 573235000100 IMP binding site; other site 573235000101 dimer interface [polypeptide binding]; other site 573235000102 interdomain contacts; other site 573235000103 partial ornithine binding site; other site 573235000104 DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476 573235000105 carnitine operon protein CaiE; Provisional; Region: PRK13627 573235000106 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 573235000107 putative trimer interface [polypeptide binding]; other site 573235000108 putative metal binding site [ion binding]; other site 573235000109 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 573235000110 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 573235000111 substrate binding site [chemical binding]; other site 573235000112 oxyanion hole (OAH) forming residues; other site 573235000113 trimer interface [polypeptide binding]; other site 573235000114 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 573235000115 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 573235000116 acyl-activating enzyme (AAE) consensus motif; other site 573235000117 putative AMP binding site [chemical binding]; other site 573235000118 putative active site [active] 573235000119 putative CoA binding site [chemical binding]; other site 573235000120 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 573235000121 CoA-transferase family III; Region: CoA_transf_3; pfam02515 573235000122 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 573235000123 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 573235000124 active site 573235000125 L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356 573235000126 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 573235000127 Ligand binding site [chemical binding]; other site 573235000128 Electron transfer flavoprotein domain; Region: ETF; pfam01012 573235000129 putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363 573235000130 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985 573235000131 Ligand binding site [chemical binding]; other site 573235000132 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 573235000133 putative oxidoreductase FixC; Provisional; Region: PRK10157 573235000134 ferredoxin-like protein FixX; Provisional; Region: PRK15449 573235000135 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235000136 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 573235000137 putative substrate translocation pore; other site 573235000138 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 573235000139 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 573235000140 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 573235000141 TrkA-N domain; Region: TrkA_N; pfam02254 573235000142 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 573235000143 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 573235000144 folate binding site [chemical binding]; other site 573235000145 NADP+ binding site [chemical binding]; other site 573235000146 Post-segregation antitoxin CcdA; Region: CcdA; cl02188 573235000147 Domain of unknown function (DUF4291); Region: DUF4291; pfam14124 573235000148 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 573235000149 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 573235000150 active site 573235000151 metal binding site [ion binding]; metal-binding site 573235000152 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 573235000153 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 573235000154 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 573235000155 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 573235000156 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 573235000157 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 573235000158 SurA N-terminal domain; Region: SurA_N; pfam09312 573235000159 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 573235000160 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 573235000161 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 573235000162 OstA-like protein; Region: OstA; pfam03968 573235000163 Organic solvent tolerance protein; Region: OstA_C; pfam04453 573235000164 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 573235000165 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 573235000166 putative metal binding site [ion binding]; other site 573235000167 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 573235000168 HSP70 interaction site [polypeptide binding]; other site 573235000169 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 573235000170 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 573235000171 active site 573235000172 ATP-dependent helicase HepA; Validated; Region: PRK04914 573235000173 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573235000174 ATP binding site [chemical binding]; other site 573235000175 putative Mg++ binding site [ion binding]; other site 573235000176 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573235000177 nucleotide binding region [chemical binding]; other site 573235000178 ATP-binding site [chemical binding]; other site 573235000179 DNA polymerase II; Reviewed; Region: PRK05762 573235000180 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 573235000181 active site 573235000182 catalytic site [active] 573235000183 substrate binding site [chemical binding]; other site 573235000184 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 573235000185 active site 573235000186 metal-binding site 573235000187 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 573235000188 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 573235000189 intersubunit interface [polypeptide binding]; other site 573235000190 active site 573235000191 Zn2+ binding site [ion binding]; other site 573235000192 L-arabinose isomerase; Provisional; Region: PRK02929 573235000193 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 573235000194 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 573235000195 trimer interface [polypeptide binding]; other site 573235000196 putative substrate binding site [chemical binding]; other site 573235000197 putative metal binding site [ion binding]; other site 573235000198 ribulokinase; Provisional; Region: PRK04123 573235000199 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 573235000200 N- and C-terminal domain interface [polypeptide binding]; other site 573235000201 active site 573235000202 MgATP binding site [chemical binding]; other site 573235000203 catalytic site [active] 573235000204 metal binding site [ion binding]; metal-binding site 573235000205 carbohydrate binding site [chemical binding]; other site 573235000206 homodimer interface [polypeptide binding]; other site 573235000207 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 573235000208 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 573235000209 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573235000210 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573235000211 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 573235000212 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 573235000213 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 573235000214 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 573235000215 Walker A/P-loop; other site 573235000216 ATP binding site [chemical binding]; other site 573235000217 Q-loop/lid; other site 573235000218 ABC transporter signature motif; other site 573235000219 Walker B; other site 573235000220 D-loop; other site 573235000221 H-loop/switch region; other site 573235000222 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 573235000223 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573235000224 dimer interface [polypeptide binding]; other site 573235000225 conserved gate region; other site 573235000226 putative PBP binding loops; other site 573235000227 ABC-ATPase subunit interface; other site 573235000228 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573235000229 dimer interface [polypeptide binding]; other site 573235000230 conserved gate region; other site 573235000231 putative PBP binding loops; other site 573235000232 ABC-ATPase subunit interface; other site 573235000233 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 573235000234 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 573235000235 transcriptional regulator SgrR; Provisional; Region: PRK13626 573235000236 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 573235000237 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 573235000238 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235000239 sugar efflux transporter; Region: 2A0120; TIGR00899 573235000240 putative substrate translocation pore; other site 573235000241 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 573235000242 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 573235000243 substrate binding site [chemical binding]; other site 573235000244 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 573235000245 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 573235000246 substrate binding site [chemical binding]; other site 573235000247 ligand binding site [chemical binding]; other site 573235000248 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 573235000249 tartrate dehydrogenase; Region: TTC; TIGR02089 573235000250 2-isopropylmalate synthase; Validated; Region: PRK00915 573235000251 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 573235000252 active site 573235000253 catalytic residues [active] 573235000254 metal binding site [ion binding]; metal-binding site 573235000255 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 573235000256 leu operon leader peptide; Provisional; Region: PRK09925 573235000257 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 573235000258 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573235000259 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 573235000260 putative substrate binding pocket [chemical binding]; other site 573235000261 putative dimerization interface [polypeptide binding]; other site 573235000262 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 573235000263 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 573235000264 PYR/PP interface [polypeptide binding]; other site 573235000265 dimer interface [polypeptide binding]; other site 573235000266 TPP binding site [chemical binding]; other site 573235000267 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 573235000268 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 573235000269 TPP-binding site [chemical binding]; other site 573235000270 dimer interface [polypeptide binding]; other site 573235000271 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 573235000272 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 573235000273 putative valine binding site [chemical binding]; other site 573235000274 dimer interface [polypeptide binding]; other site 573235000275 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 573235000276 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 573235000277 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573235000278 DNA binding site [nucleotide binding] 573235000279 domain linker motif; other site 573235000280 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 573235000281 dimerization interface [polypeptide binding]; other site 573235000282 ligand binding site [chemical binding]; other site 573235000283 mraZ protein; Region: TIGR00242 573235000284 MraZ protein; Region: MraZ; pfam02381 573235000285 MraZ protein; Region: MraZ; pfam02381 573235000286 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 573235000287 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 573235000288 cell division protein FtsL; Provisional; Region: PRK10772 573235000289 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 573235000290 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 573235000291 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 573235000292 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 573235000293 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 573235000294 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 573235000295 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 573235000296 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 573235000297 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 573235000298 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 573235000299 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 573235000300 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 573235000301 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 573235000302 Mg++ binding site [ion binding]; other site 573235000303 putative catalytic motif [active] 573235000304 putative substrate binding site [chemical binding]; other site 573235000305 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 573235000306 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 573235000307 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 573235000308 cell division protein FtsW; Provisional; Region: PRK10774 573235000309 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 573235000310 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 573235000311 active site 573235000312 homodimer interface [polypeptide binding]; other site 573235000313 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 573235000314 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 573235000315 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 573235000316 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 573235000317 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 573235000318 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 573235000319 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 573235000320 cell division protein FtsQ; Provisional; Region: PRK10775 573235000321 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 573235000322 Cell division protein FtsQ; Region: FtsQ; pfam03799 573235000323 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 573235000324 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 573235000325 Cell division protein FtsA; Region: FtsA; pfam14450 573235000326 cell division protein FtsZ; Validated; Region: PRK09330 573235000327 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 573235000328 nucleotide binding site [chemical binding]; other site 573235000329 SulA interaction site; other site 573235000330 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 573235000331 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 573235000332 SecA regulator SecM; Provisional; Region: PRK02943 573235000333 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 573235000334 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 573235000335 SEC-C motif; Region: SEC-C; pfam02810 573235000336 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 573235000337 active site 573235000338 8-oxo-dGMP binding site [chemical binding]; other site 573235000339 nudix motif; other site 573235000340 metal binding site [ion binding]; metal-binding site 573235000341 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 573235000342 Transposase; Region: DEDD_Tnp_IS110; pfam01548 573235000343 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 573235000344 DNA gyrase inhibitor; Reviewed; Region: PRK00418 573235000345 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 573235000346 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 573235000347 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 573235000348 CoA-binding site [chemical binding]; other site 573235000349 ATP-binding [chemical binding]; other site 573235000350 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 573235000351 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 573235000352 active site 573235000353 type IV pilin biogenesis protein; Provisional; Region: PRK10573 573235000354 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 573235000355 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 573235000356 hypothetical protein; Provisional; Region: PRK10436 573235000357 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 573235000358 Walker A motif; other site 573235000359 ATP binding site [chemical binding]; other site 573235000360 Walker B motif; other site 573235000361 putative major pilin subunit; Provisional; Region: PRK10574 573235000362 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 573235000363 Pilin (bacterial filament); Region: Pilin; pfam00114 573235000364 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 573235000365 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 573235000366 dimerization interface [polypeptide binding]; other site 573235000367 active site 573235000368 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 573235000369 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 573235000370 amidase catalytic site [active] 573235000371 Zn binding residues [ion binding]; other site 573235000372 substrate binding site [chemical binding]; other site 573235000373 regulatory protein AmpE; Provisional; Region: PRK10987 573235000374 aromatic amino acid transporter; Provisional; Region: PRK10238 573235000375 Transcriptional regulators [Transcription]; Region: FadR; COG2186 573235000376 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573235000377 DNA-binding site [nucleotide binding]; DNA binding site 573235000378 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 573235000379 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 573235000380 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 573235000381 dimer interface [polypeptide binding]; other site 573235000382 TPP-binding site [chemical binding]; other site 573235000383 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 573235000384 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 573235000385 E3 interaction surface; other site 573235000386 lipoyl attachment site [posttranslational modification]; other site 573235000387 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 573235000388 E3 interaction surface; other site 573235000389 lipoyl attachment site [posttranslational modification]; other site 573235000390 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 573235000391 E3 interaction surface; other site 573235000392 lipoyl attachment site [posttranslational modification]; other site 573235000393 e3 binding domain; Region: E3_binding; pfam02817 573235000394 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 573235000395 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 573235000396 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 573235000397 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 573235000398 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 573235000399 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 573235000400 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 573235000401 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 573235000402 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 573235000403 substrate binding site [chemical binding]; other site 573235000404 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 573235000405 substrate binding site [chemical binding]; other site 573235000406 ligand binding site [chemical binding]; other site 573235000407 hypothetical protein; Provisional; Region: PRK05248 573235000408 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 573235000409 spermidine synthase; Provisional; Region: PRK00811 573235000410 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573235000411 S-adenosylmethionine binding site [chemical binding]; other site 573235000412 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 573235000413 multicopper oxidase; Provisional; Region: PRK10965 573235000414 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 573235000415 Multicopper oxidase; Region: Cu-oxidase; pfam00394 573235000416 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 573235000417 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 573235000418 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 573235000419 Trp docking motif [polypeptide binding]; other site 573235000420 putative active site [active] 573235000421 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 573235000422 active site 573235000423 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 573235000424 active site clefts [active] 573235000425 zinc binding site [ion binding]; other site 573235000426 dimer interface [polypeptide binding]; other site 573235000427 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 573235000428 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 573235000429 Walker A/P-loop; other site 573235000430 ATP binding site [chemical binding]; other site 573235000431 Q-loop/lid; other site 573235000432 ABC transporter signature motif; other site 573235000433 Walker B; other site 573235000434 D-loop; other site 573235000435 H-loop/switch region; other site 573235000436 inner membrane transport permease; Provisional; Region: PRK15066 573235000437 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 573235000438 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 573235000439 active pocket/dimerization site; other site 573235000440 active site 573235000441 phosphorylation site [posttranslational modification] 573235000442 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 573235000443 putative active site [active] 573235000444 putative metal binding site [ion binding]; other site 573235000445 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 573235000446 tetramerization interface [polypeptide binding]; other site 573235000447 active site 573235000448 Uncharacterized conserved protein [Function unknown]; Region: COG5464 573235000449 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 573235000450 pantoate--beta-alanine ligase; Region: panC; TIGR00018 573235000451 Pantoate-beta-alanine ligase; Region: PanC; cd00560 573235000452 active site 573235000453 ATP-binding site [chemical binding]; other site 573235000454 pantoate-binding site; other site 573235000455 HXXH motif; other site 573235000456 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 573235000457 oligomerization interface [polypeptide binding]; other site 573235000458 active site 573235000459 metal binding site [ion binding]; metal-binding site 573235000460 predicted fimbrial, C-terminal part 573235000461 predicted fimbrial, N-terminal part 573235000462 putative fimbrial protein StaF; Provisional; Region: PRK15262 573235000463 putative fimbrial protein StaE; Provisional; Region: PRK15263 573235000464 Fimbrial protein; Region: Fimbrial; cl01416 573235000465 putative fimbrial outer membrane usher protein; Provisional; Region: PRK09828 573235000466 PapC N-terminal domain; Region: PapC_N; pfam13954 573235000467 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 573235000468 PapC C-terminal domain; Region: PapC_C; pfam13953 573235000469 putative chaperone protein EcpD; Provisional; Region: PRK09926 573235000470 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 573235000471 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 573235000472 Fimbrial protein; Region: Fimbrial; cl01416 573235000473 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 573235000474 catalytic center binding site [active] 573235000475 ATP binding site [chemical binding]; other site 573235000476 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 573235000477 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 573235000478 active site 573235000479 NTP binding site [chemical binding]; other site 573235000480 metal binding triad [ion binding]; metal-binding site 573235000481 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 573235000482 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 573235000483 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 573235000484 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 573235000485 active site 573235000486 nucleotide binding site [chemical binding]; other site 573235000487 HIGH motif; other site 573235000488 KMSKS motif; other site 573235000489 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 573235000490 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 573235000491 2'-5' RNA ligase; Provisional; Region: PRK15124 573235000492 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 573235000493 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 573235000494 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 573235000495 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573235000496 ATP binding site [chemical binding]; other site 573235000497 putative Mg++ binding site [ion binding]; other site 573235000498 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573235000499 nucleotide binding region [chemical binding]; other site 573235000500 ATP-binding site [chemical binding]; other site 573235000501 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 573235000502 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 573235000503 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 573235000504 Transglycosylase; Region: Transgly; pfam00912 573235000505 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 573235000506 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 573235000507 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 573235000508 N-terminal plug; other site 573235000509 ligand-binding site [chemical binding]; other site 573235000510 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 573235000511 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 573235000512 Walker A/P-loop; other site 573235000513 ATP binding site [chemical binding]; other site 573235000514 Q-loop/lid; other site 573235000515 ABC transporter signature motif; other site 573235000516 Walker B; other site 573235000517 D-loop; other site 573235000518 H-loop/switch region; other site 573235000519 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 573235000520 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 573235000521 siderophore binding site; other site 573235000522 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 573235000523 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 573235000524 ABC-ATPase subunit interface; other site 573235000525 dimer interface [polypeptide binding]; other site 573235000526 putative PBP binding regions; other site 573235000527 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 573235000528 ABC-ATPase subunit interface; other site 573235000529 dimer interface [polypeptide binding]; other site 573235000530 putative PBP binding regions; other site 573235000531 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 573235000532 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 573235000533 inhibitor-cofactor binding pocket; inhibition site 573235000534 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573235000535 catalytic residue [active] 573235000536 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 573235000537 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 573235000538 Cl- selectivity filter; other site 573235000539 Cl- binding residues [ion binding]; other site 573235000540 pore gating glutamate residue; other site 573235000541 dimer interface [polypeptide binding]; other site 573235000542 H+/Cl- coupling transport residue; other site 573235000543 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 573235000544 hypothetical protein; Provisional; Region: PRK10578 573235000545 UPF0126 domain; Region: UPF0126; pfam03458 573235000546 UPF0126 domain; Region: UPF0126; pfam03458 573235000547 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 573235000548 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 573235000549 cobalamin binding residues [chemical binding]; other site 573235000550 putative BtuC binding residues; other site 573235000551 dimer interface [polypeptide binding]; other site 573235000552 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 573235000553 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 573235000554 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 573235000555 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573235000556 Zn2+ binding site [ion binding]; other site 573235000557 Mg2+ binding site [ion binding]; other site 573235000558 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 573235000559 serine endoprotease; Provisional; Region: PRK10942 573235000560 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 573235000561 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 573235000562 protein binding site [polypeptide binding]; other site 573235000563 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 573235000564 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 573235000565 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 573235000566 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 573235000567 hypothetical protein; Provisional; Region: PRK13677 573235000568 phosphodiesterase YaeI; Provisional; Region: PRK11340 573235000569 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 573235000570 putative active site [active] 573235000571 putative metal binding site [ion binding]; other site 573235000572 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 573235000573 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 573235000574 trimer interface [polypeptide binding]; other site 573235000575 active site 573235000576 substrate binding site [chemical binding]; other site 573235000577 CoA binding site [chemical binding]; other site 573235000578 PII uridylyl-transferase; Provisional; Region: PRK05007 573235000579 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 573235000580 metal binding triad; other site 573235000581 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 573235000582 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573235000583 Zn2+ binding site [ion binding]; other site 573235000584 Mg2+ binding site [ion binding]; other site 573235000585 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 573235000586 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 573235000587 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 573235000588 active site 573235000589 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 573235000590 rRNA interaction site [nucleotide binding]; other site 573235000591 S8 interaction site; other site 573235000592 putative laminin-1 binding site; other site 573235000593 elongation factor Ts; Provisional; Region: tsf; PRK09377 573235000594 UBA/TS-N domain; Region: UBA; pfam00627 573235000595 Elongation factor TS; Region: EF_TS; pfam00889 573235000596 Elongation factor TS; Region: EF_TS; pfam00889 573235000597 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 573235000598 putative nucleotide binding site [chemical binding]; other site 573235000599 uridine monophosphate binding site [chemical binding]; other site 573235000600 homohexameric interface [polypeptide binding]; other site 573235000601 ribosome recycling factor; Reviewed; Region: frr; PRK00083 573235000602 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 573235000603 hinge region; other site 573235000604 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 573235000605 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 573235000606 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 573235000607 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 573235000608 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 573235000609 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 573235000610 catalytic residue [active] 573235000611 putative FPP diphosphate binding site; other site 573235000612 putative FPP binding hydrophobic cleft; other site 573235000613 dimer interface [polypeptide binding]; other site 573235000614 putative IPP diphosphate binding site; other site 573235000615 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 573235000616 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 573235000617 zinc metallopeptidase RseP; Provisional; Region: PRK10779 573235000618 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 573235000619 active site 573235000620 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 573235000621 protein binding site [polypeptide binding]; other site 573235000622 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 573235000623 putative substrate binding region [chemical binding]; other site 573235000624 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 573235000625 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 573235000626 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 573235000627 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 573235000628 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 573235000629 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 573235000630 Surface antigen; Region: Bac_surface_Ag; pfam01103 573235000631 periplasmic chaperone; Provisional; Region: PRK10780 573235000632 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 573235000633 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 573235000634 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 573235000635 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 573235000636 trimer interface [polypeptide binding]; other site 573235000637 active site 573235000638 UDP-GlcNAc binding site [chemical binding]; other site 573235000639 lipid binding site [chemical binding]; lipid-binding site 573235000640 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 573235000641 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 573235000642 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 573235000643 active site 573235000644 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 573235000645 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 573235000646 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 573235000647 RNA/DNA hybrid binding site [nucleotide binding]; other site 573235000648 active site 573235000649 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 573235000650 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 573235000651 putative active site [active] 573235000652 putative PHP Thumb interface [polypeptide binding]; other site 573235000653 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 573235000654 generic binding surface II; other site 573235000655 generic binding surface I; other site 573235000656 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 573235000657 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 573235000658 lysine decarboxylase LdcC; Provisional; Region: PRK15399 573235000659 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 573235000660 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 573235000661 homodimer interface [polypeptide binding]; other site 573235000662 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573235000663 catalytic residue [active] 573235000664 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 573235000665 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 573235000666 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 573235000667 putative metal binding site [ion binding]; other site 573235000668 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 573235000669 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 573235000670 Ligand Binding Site [chemical binding]; other site 573235000671 TilS substrate binding domain; Region: TilS; pfam09179 573235000672 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 573235000673 Rho-binding antiterminator; Provisional; Region: PRK11625 573235000674 hypothetical protein; Provisional; Region: PRK04964 573235000675 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 573235000676 hypothetical protein; Provisional; Region: PRK09256 573235000677 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 573235000678 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 573235000679 NlpE N-terminal domain; Region: NlpE; pfam04170 573235000680 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 573235000681 Transposase; Region: DEDD_Tnp_IS110; pfam01548 573235000682 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 573235000683 predicted lipoprotein, C-terminal part 573235000684 predicted lipoprotein, N-terminal part 573235000685 prolyl-tRNA synthetase; Provisional; Region: PRK09194 573235000686 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 573235000687 dimer interface [polypeptide binding]; other site 573235000688 motif 1; other site 573235000689 active site 573235000690 motif 2; other site 573235000691 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 573235000692 putative deacylase active site [active] 573235000693 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 573235000694 active site 573235000695 motif 3; other site 573235000696 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 573235000697 anticodon binding site; other site 573235000698 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 573235000699 homodimer interaction site [polypeptide binding]; other site 573235000700 cofactor binding site; other site 573235000701 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 573235000702 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 573235000703 lipoprotein, YaeC family; Region: TIGR00363 573235000704 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573235000705 dimer interface [polypeptide binding]; other site 573235000706 conserved gate region; other site 573235000707 ABC-ATPase subunit interface; other site 573235000708 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 573235000709 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 573235000710 Walker A/P-loop; other site 573235000711 ATP binding site [chemical binding]; other site 573235000712 Q-loop/lid; other site 573235000713 ABC transporter signature motif; other site 573235000714 Walker B; other site 573235000715 D-loop; other site 573235000716 H-loop/switch region; other site 573235000717 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 573235000718 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 573235000719 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573235000720 active site 573235000721 motif I; other site 573235000722 motif II; other site 573235000723 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 573235000724 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 573235000725 active site 573235000726 catalytic tetrad [active] 573235000727 Transcriptional regulator [Transcription]; Region: LysR; COG0583 573235000728 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573235000729 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 573235000730 putative effector binding pocket; other site 573235000731 dimerization interface [polypeptide binding]; other site 573235000732 hypothetical protein; Provisional; Region: PRK05421 573235000733 putative catalytic site [active] 573235000734 putative metal binding site [ion binding]; other site 573235000735 putative phosphate binding site [ion binding]; other site 573235000736 putative catalytic site [active] 573235000737 putative phosphate binding site [ion binding]; other site 573235000738 putative metal binding site [ion binding]; other site 573235000739 Methyltransferase domain; Region: Methyltransf_31; pfam13847 573235000740 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573235000741 S-adenosylmethionine binding site [chemical binding]; other site 573235000742 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 573235000743 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 573235000744 N-acetyl-D-glucosamine binding site [chemical binding]; other site 573235000745 catalytic residue [active] 573235000746 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 573235000747 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 573235000748 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 573235000749 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573235000750 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 573235000751 RNA/DNA hybrid binding site [nucleotide binding]; other site 573235000752 active site 573235000753 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 573235000754 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 573235000755 active site 573235000756 catalytic site [active] 573235000757 substrate binding site [chemical binding]; other site 573235000758 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 573235000759 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 573235000760 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 573235000761 ImpA domain protein; Region: DUF3702; pfam12486 573235000762 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 573235000763 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 573235000764 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 573235000765 conserved predicted protein, C-terminal part 573235000766 conserved predicted protein, N-terminal part 573235000767 type VI secretion-associated protein, VC_A0118 family; Region: VI_minor_1; TIGR03360 573235000768 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573235000769 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 573235000770 Walker A motif; other site 573235000771 ATP binding site [chemical binding]; other site 573235000772 Walker B motif; other site 573235000773 arginine finger; other site 573235000774 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573235000775 Walker A motif; other site 573235000776 ATP binding site [chemical binding]; other site 573235000777 Walker B motif; other site 573235000778 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 573235000779 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 573235000780 conserved predicted protein, C-terminal part 573235000781 conserved predicted protein, N-terminal part 573235000782 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3521 573235000783 conserved predicted protein, C-terminal part (pseudogene) 573235000784 RHS Repeat; Region: RHS_repeat; cl11982 573235000785 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 573235000786 RHS Repeat; Region: RHS_repeat; pfam05593 573235000787 RHS Repeat; Region: RHS_repeat; cl11982 573235000788 RHS Repeat; Region: RHS_repeat; pfam05593 573235000789 RHS protein; Region: RHS; pfam03527 573235000790 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 573235000791 Rhs, IS677, H repeat-associated protein, N-terminal fragment 573235000792 RhsG, IS677, H repeat-associated protein, C-terminal part 573235000793 C-N hydrolase family amidase; Provisional; Region: PRK10438 573235000794 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 573235000795 putative active site [active] 573235000796 catalytic triad [active] 573235000797 dimer interface [polypeptide binding]; other site 573235000798 multimer interface [polypeptide binding]; other site 573235000799 C-lysozyme inhibitor; Provisional; Region: PRK09993 573235000800 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 573235000801 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 573235000802 active site 573235000803 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 573235000804 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 573235000805 dimer interface [polypeptide binding]; other site 573235000806 active site 573235000807 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 573235000808 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 573235000809 putative active site [active] 573235000810 putative dimer interface [polypeptide binding]; other site 573235000811 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 573235000812 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 573235000813 predicted toxin of the YafQ-DinJ toxin-antitoxin system, C-terminal part 573235000814 RelB antitoxin; Region: RelB; cl01171 573235000815 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 573235000816 NlpC/P60 family; Region: NLPC_P60; pfam00877 573235000817 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 573235000818 HicB family; Region: HicB; pfam05534 573235000819 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298 573235000820 FHIPEP family; Region: FHIPEP; pfam00771 573235000821 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 573235000822 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 573235000823 Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684 573235000824 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 573235000825 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 573235000826 flagellar motor switch protein FliN; Region: fliN; TIGR02480 573235000827 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 573235000828 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 573235000829 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573235000830 Walker A motif; other site 573235000831 ATP binding site [chemical binding]; other site 573235000832 Walker B motif; other site 573235000833 arginine finger; other site 573235000834 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 573235000835 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 573235000836 flagellar MS-ring protein; Reviewed; Region: fliF; PRK07193 573235000837 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 573235000838 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 573235000839 flagellar motor switch protein G; Reviewed; Region: fliG; PRK07194 573235000840 MgtE intracellular N domain; Region: MgtE_N; smart00924 573235000841 FliG C-terminal domain; Region: FliG_C; pfam01706 573235000842 flagellar assembly protein H; Provisional; Region: fliH; PRK13386 573235000843 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 573235000844 Flagellar assembly protein FliH; Region: FliH; pfam02108 573235000845 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07196 573235000846 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 573235000847 Walker A motif/ATP binding site; other site 573235000848 Walker B motif; other site 573235000849 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 573235000850 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 573235000851 active site 573235000852 nucleotide binding site [chemical binding]; other site 573235000853 HIGH motif; other site 573235000854 KMSKS motif; other site 573235000855 predicted glycosyltransferase, C-terminal part 573235000856 predicted glycosyltransferase, N-terminal part 573235000857 FlgN protein; Region: FlgN; pfam05130 573235000858 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 573235000859 SAF-like; Region: SAF_2; pfam13144 573235000860 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 573235000861 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 573235000862 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 573235000863 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK12685 573235000864 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK06802 573235000865 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 573235000866 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK09619 573235000867 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 573235000868 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 573235000869 flagellar hook protein FlgE; Validated; Region: flgE; PRK06803 573235000870 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 573235000871 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 573235000872 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 573235000873 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 573235000874 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 573235000875 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 573235000876 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 573235000877 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 573235000878 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12407 573235000879 Flagellar L-ring protein; Region: FlgH; pfam02107 573235000880 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 573235000881 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 573235000882 Rod binding protein; Region: Rod-binding; cl01626 573235000883 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07191 573235000884 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 573235000885 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK07192 573235000886 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 573235000887 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 573235000888 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573235000889 DNA binding site [nucleotide binding] 573235000890 flagellin; Reviewed; Region: PRK08869 573235000891 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 573235000892 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 573235000893 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 573235000894 Flagellar protein FliS; Region: FliS; cl00654 573235000895 adenylate kinase; Region: PLN02674 573235000896 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 573235000897 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 573235000898 flagellar biosynthesis sigma factor; Provisional; Region: PRK12427 573235000899 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573235000900 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573235000901 DNA binding residues [nucleotide binding] 573235000902 flagellar motor protein MotA; Provisional; Region: PRK12482 573235000903 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 573235000904 hypothetical protein; Validated; Region: PRK06778 573235000905 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 573235000906 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 573235000907 ligand binding site [chemical binding]; other site 573235000908 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 573235000909 active site 573235000910 DNA polymerase IV; Validated; Region: PRK02406 573235000911 DNA binding site [nucleotide binding] 573235000912 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 573235000913 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573235000914 Coenzyme A binding pocket [chemical binding]; other site 573235000915 hypothetical protein; Reviewed; Region: PRK09588 573235000916 release factor H-coupled RctB family protein; Region: release_rtcB; TIGR03073 573235000917 peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179 573235000918 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 573235000919 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 573235000920 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 573235000921 metal binding site [ion binding]; metal-binding site 573235000922 dimer interface [polypeptide binding]; other site 573235000923 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 573235000924 active site 573235000925 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 573235000926 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 573235000927 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 573235000928 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 573235000929 trimer interface [polypeptide binding]; other site 573235000930 eyelet of channel; other site 573235000931 gamma-glutamyl kinase; Provisional; Region: PRK05429 573235000932 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 573235000933 nucleotide binding site [chemical binding]; other site 573235000934 homotetrameric interface [polypeptide binding]; other site 573235000935 putative phosphate binding site [ion binding]; other site 573235000936 putative allosteric binding site; other site 573235000937 PUA domain; Region: PUA; pfam01472 573235000938 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 573235000939 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 573235000940 putative catalytic cysteine [active] 573235000941 Integrative element ECO26_IE01 573235000942 Helix-turn-helix domain; Region: HTH_36; pfam13730 573235000943 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 573235000944 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 573235000945 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 573235000946 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 573235000947 active site 573235000948 DNA binding site [nucleotide binding] 573235000949 Int/Topo IB signature motif; other site 573235000950 predicted transcriptional regulator, LYSR-type, C-terminal fragment 573235000951 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 573235000952 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 573235000953 XdhC Rossmann domain; Region: XdhC_C; pfam13478 573235000954 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 573235000955 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 573235000956 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 573235000957 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 573235000958 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 573235000959 aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433 573235000960 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 573235000961 catalytic loop [active] 573235000962 iron binding site [ion binding]; other site 573235000963 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 573235000964 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 573235000965 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 573235000966 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 573235000967 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 573235000968 putative fimbrial protein TcfA; Provisional; Region: PRK15308 573235000969 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 573235000970 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573235000971 DNA binding residues [nucleotide binding] 573235000972 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 573235000973 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 573235000974 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 573235000975 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 573235000976 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 573235000977 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 573235000978 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 573235000979 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 573235000980 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573235000981 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 573235000982 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 573235000983 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 573235000984 active site 573235000985 catalytic tetrad [active] 573235000986 Predicted membrane protein [Function unknown]; Region: COG3059 573235000987 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 573235000988 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010 573235000989 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 573235000990 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 573235000991 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 573235000992 Cupin; Region: Cupin_6; pfam12852 573235000993 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 573235000994 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573235000995 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 573235000996 Cysteine-rich domain; Region: CCG; pfam02754 573235000997 Cysteine-rich domain; Region: CCG; pfam02754 573235000998 iron-sulfur cluster-binding protein; Region: TIGR00273 573235000999 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 573235001000 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 573235001001 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 573235001002 Uncharacterized conserved protein [Function unknown]; Region: COG1556 573235001003 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 573235001004 choline dehydrogenase; Validated; Region: PRK02106 573235001005 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 573235001006 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 573235001007 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 573235001008 tetrameric interface [polypeptide binding]; other site 573235001009 NAD binding site [chemical binding]; other site 573235001010 catalytic residues [active] 573235001011 transcriptional regulator BetI; Validated; Region: PRK00767 573235001012 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573235001013 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 573235001014 choline transport protein BetT; Provisional; Region: PRK09928 573235001015 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 573235001016 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 573235001017 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 573235001018 Autotransporter beta-domain; Region: Autotransporter; pfam03797 573235001019 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573235001020 DNA binding residues [nucleotide binding] 573235001021 dimerization interface [polypeptide binding]; other site 573235001022 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 573235001023 predicted DNA-binding transcriptional regulator, LYSR-type, N-terminal fragment 573235001024 predicted inner membrane protein, C-terminal fragment 573235001025 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 573235001026 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 573235001027 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 573235001028 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 573235001029 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 573235001030 CoA binding domain; Region: CoA_binding; pfam02629 573235001031 CoA-ligase; Region: Ligase_CoA; pfam00549 573235001032 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 573235001033 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 573235001034 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 573235001035 putative substrate binding site [chemical binding]; other site 573235001036 nucleotide binding site [chemical binding]; other site 573235001037 nucleotide binding site [chemical binding]; other site 573235001038 homodimer interface [polypeptide binding]; other site 573235001039 putative deaminase; Validated; Region: PRK06846 573235001040 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 573235001041 active site 573235001042 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 573235001043 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 573235001044 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 573235001045 ligand binding site [chemical binding]; other site 573235001046 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 573235001047 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 573235001048 Walker A/P-loop; other site 573235001049 ATP binding site [chemical binding]; other site 573235001050 Q-loop/lid; other site 573235001051 ABC transporter signature motif; other site 573235001052 Walker B; other site 573235001053 D-loop; other site 573235001054 H-loop/switch region; other site 573235001055 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 573235001056 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 573235001057 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573235001058 TM-ABC transporter signature motif; other site 573235001059 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573235001060 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 573235001061 TM-ABC transporter signature motif; other site 573235001062 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 573235001063 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 573235001064 putative NAD(P) binding site [chemical binding]; other site 573235001065 putative substrate binding site [chemical binding]; other site 573235001066 catalytic Zn binding site [ion binding]; other site 573235001067 structural Zn binding site [ion binding]; other site 573235001068 dimer interface [polypeptide binding]; other site 573235001069 The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949 573235001070 hypothetical protein; Provisional; Region: PRK09929 573235001071 propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424 573235001072 Propionate catabolism activator; Region: PrpR_N; pfam06506 573235001073 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573235001074 Walker A motif; other site 573235001075 ATP binding site [chemical binding]; other site 573235001076 Walker B motif; other site 573235001077 arginine finger; other site 573235001078 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 573235001079 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 573235001080 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 573235001081 tetramer interface [polypeptide binding]; other site 573235001082 active site 573235001083 Mg2+/Mn2+ binding site [ion binding]; other site 573235001084 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 573235001085 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 573235001086 dimer interface [polypeptide binding]; other site 573235001087 active site 573235001088 citrylCoA binding site [chemical binding]; other site 573235001089 oxalacetate/citrate binding site [chemical binding]; other site 573235001090 coenzyme A binding site [chemical binding]; other site 573235001091 catalytic triad [active] 573235001092 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 573235001093 2-methylcitrate dehydratase; Region: prpD; TIGR02330 573235001094 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 573235001095 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 573235001096 acyl-activating enzyme (AAE) consensus motif; other site 573235001097 putative AMP binding site [chemical binding]; other site 573235001098 putative active site [active] 573235001099 putative CoA binding site [chemical binding]; other site 573235001100 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 573235001101 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 573235001102 Na binding site [ion binding]; other site 573235001103 putative substrate binding site [chemical binding]; other site 573235001104 cytosine deaminase; Provisional; Region: PRK09230 573235001105 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 573235001106 active site 573235001107 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 573235001108 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573235001109 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425 573235001110 dimerization interface [polypeptide binding]; other site 573235001111 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 573235001112 active site clefts [active] 573235001113 zinc binding site [ion binding]; other site 573235001114 dimer interface [polypeptide binding]; other site 573235001115 Cyanate lyase [Inorganic ion transport and metabolism]; Region: CynS; COG1513 573235001116 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 573235001117 oligomer interface [polypeptide binding]; other site 573235001118 active site 573235001119 putative cyanate transporter; Provisional; Region: cynX; PRK09705 573235001120 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235001121 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 573235001122 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235001123 putative substrate translocation pore; other site 573235001124 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 573235001125 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 573235001126 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 573235001127 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 573235001128 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 573235001129 lac repressor; Reviewed; Region: lacI; PRK09526 573235001130 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573235001131 DNA binding site [nucleotide binding] 573235001132 domain linker motif; other site 573235001133 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 573235001134 ligand binding site [chemical binding]; other site 573235001135 dimerization interface (open form) [polypeptide binding]; other site 573235001136 dimerization interface (closed form) [polypeptide binding]; other site 573235001137 DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834 573235001138 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 573235001139 Bacterial transcriptional regulator; Region: IclR; pfam01614 573235001140 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 573235001141 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 573235001142 Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB), which catalyzes the oxidization and subsequent ring-opening of 2,3-dihydroxyphenylpropionate; Region: MhpB_like; cd07365 573235001143 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 573235001144 putative active site [active] 573235001145 Fe(II) binding site [ion binding]; other site 573235001146 putative dimer interface [polypeptide binding]; other site 573235001147 putative tetramer interface [polypeptide binding]; other site 573235001148 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 573235001149 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 573235001150 nucleophilic elbow; other site 573235001151 catalytic triad; other site 573235001152 2-keto-4-pentenoate hydratase; Provisional; Region: mhpD; PRK11342 573235001153 acetaldehyde dehydrogenase; Validated; Region: PRK08300 573235001154 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 573235001155 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 573235001156 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 573235001157 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 573235001158 active site 573235001159 catalytic residues [active] 573235001160 metal binding site [ion binding]; metal-binding site 573235001161 DmpG-like communication domain; Region: DmpG_comm; pfam07836 573235001162 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 573235001163 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235001164 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235001165 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 573235001166 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 573235001167 S-formylglutathione hydrolase; Region: PLN02442 573235001168 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 573235001169 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 573235001170 substrate binding site [chemical binding]; other site 573235001171 catalytic Zn binding site [ion binding]; other site 573235001172 NAD binding site [chemical binding]; other site 573235001173 structural Zn binding site [ion binding]; other site 573235001174 dimer interface [polypeptide binding]; other site 573235001175 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 573235001176 putative metal binding site [ion binding]; other site 573235001177 putative homodimer interface [polypeptide binding]; other site 573235001178 putative homotetramer interface [polypeptide binding]; other site 573235001179 putative homodimer-homodimer interface [polypeptide binding]; other site 573235001180 putative allosteric switch controlling residues; other site 573235001181 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 573235001182 putative trimer interface [polypeptide binding]; other site 573235001183 putative CoA binding site [chemical binding]; other site 573235001184 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 573235001185 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 573235001186 DXD motif; other site 573235001187 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 573235001188 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 573235001189 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 573235001190 substrate binding pocket [chemical binding]; other site 573235001191 membrane-bound complex binding site; other site 573235001192 hinge residues; other site 573235001193 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 573235001194 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 573235001195 Walker A/P-loop; other site 573235001196 ATP binding site [chemical binding]; other site 573235001197 Q-loop/lid; other site 573235001198 ABC transporter signature motif; other site 573235001199 Walker B; other site 573235001200 D-loop; other site 573235001201 H-loop/switch region; other site 573235001202 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 573235001203 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573235001204 dimer interface [polypeptide binding]; other site 573235001205 conserved gate region; other site 573235001206 putative PBP binding loops; other site 573235001207 ABC-ATPase subunit interface; other site 573235001208 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 573235001209 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 573235001210 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 573235001211 dimer interface [polypeptide binding]; other site 573235001212 active site 573235001213 Schiff base residues; other site 573235001214 Transposase; Region: HTH_Tnp_1; cl17663 573235001215 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 573235001216 predicted transposase InsF of insertion sequence IS3, N-terminal part 573235001217 predicted transposase InsF of insertion sequence IS3, C-terminal part 573235001218 predicted flagellin structural protein, N-terminal part 573235001219 predicted flagellin structural protein, C-terminal part 573235001220 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 573235001221 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 573235001222 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 573235001223 microcin B17 transporter; Reviewed; Region: PRK11098 573235001224 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 573235001225 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 573235001226 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 573235001227 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 573235001228 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 573235001229 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 573235001230 anti-RssB factor; Provisional; Region: PRK10244 573235001231 alkaline phosphatase; Provisional; Region: PRK10518 573235001232 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 573235001233 dimer interface [polypeptide binding]; other site 573235001234 active site 573235001235 hypothetical protein; Provisional; Region: PRK11505 573235001236 psiF repeat; Region: PsiF_repeat; pfam07769 573235001237 psiF repeat; Region: PsiF_repeat; pfam07769 573235001238 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 573235001239 MASE2 domain; Region: MASE2; pfam05230 573235001240 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573235001241 metal binding site [ion binding]; metal-binding site 573235001242 active site 573235001243 I-site; other site 573235001244 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 573235001245 pyrroline-5-carboxylate reductase; Region: PLN02688 573235001246 hypothetical protein; Validated; Region: PRK00124 573235001247 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 573235001248 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 573235001249 ADP binding site [chemical binding]; other site 573235001250 magnesium binding site [ion binding]; other site 573235001251 putative shikimate binding site; other site 573235001252 hypothetical protein; Provisional; Region: PRK10380 573235001253 hypothetical protein; Provisional; Region: PRK10481 573235001254 hypothetical protein; Provisional; Region: PRK10579 573235001255 conserved predicted protein, C-terminal part 573235001256 DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974 573235001257 fructokinase; Reviewed; Region: PRK09557 573235001258 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 573235001259 nucleotide binding site [chemical binding]; other site 573235001260 MFS transport protein AraJ; Provisional; Region: PRK10091 573235001261 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235001262 putative substrate translocation pore; other site 573235001263 exonuclease subunit SbcC; Provisional; Region: PRK10246 573235001264 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573235001265 Walker A/P-loop; other site 573235001266 ATP binding site [chemical binding]; other site 573235001267 Q-loop/lid; other site 573235001268 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573235001269 ABC transporter signature motif; other site 573235001270 Walker B; other site 573235001271 D-loop; other site 573235001272 H-loop/switch region; other site 573235001273 exonuclease subunit SbcD; Provisional; Region: PRK10966 573235001274 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 573235001275 active site 573235001276 metal binding site [ion binding]; metal-binding site 573235001277 DNA binding site [nucleotide binding] 573235001278 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 573235001279 transcriptional regulator PhoB; Provisional; Region: PRK10161 573235001280 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573235001281 active site 573235001282 phosphorylation site [posttranslational modification] 573235001283 intermolecular recognition site; other site 573235001284 dimerization interface [polypeptide binding]; other site 573235001285 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573235001286 DNA binding site [nucleotide binding] 573235001287 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 573235001288 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 573235001289 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573235001290 putative active site [active] 573235001291 heme pocket [chemical binding]; other site 573235001292 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573235001293 dimer interface [polypeptide binding]; other site 573235001294 phosphorylation site [posttranslational modification] 573235001295 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573235001296 ATP binding site [chemical binding]; other site 573235001297 Mg2+ binding site [ion binding]; other site 573235001298 G-X-G motif; other site 573235001299 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 573235001300 putative proline-specific permease; Provisional; Region: proY; PRK10580 573235001301 Spore germination protein; Region: Spore_permease; cl17796 573235001302 maltodextrin glucosidase; Provisional; Region: PRK10785 573235001303 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 573235001304 homodimer interface [polypeptide binding]; other site 573235001305 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 573235001306 active site 573235001307 homodimer interface [polypeptide binding]; other site 573235001308 catalytic site [active] 573235001309 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 573235001310 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 573235001311 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 573235001312 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 573235001313 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 573235001314 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 573235001315 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 573235001316 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 573235001317 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 573235001318 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 573235001319 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 573235001320 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 573235001321 Protein export membrane protein; Region: SecD_SecF; pfam02355 573235001322 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 573235001323 active site 573235001324 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 573235001325 hypothetical protein; Provisional; Region: PRK11530 573235001326 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 573235001327 ATP cone domain; Region: ATP-cone; pfam03477 573235001328 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 573235001329 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 573235001330 catalytic motif [active] 573235001331 Zn binding site [ion binding]; other site 573235001332 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 573235001333 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 573235001334 homopentamer interface [polypeptide binding]; other site 573235001335 active site 573235001336 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 573235001337 putative RNA binding site [nucleotide binding]; other site 573235001338 thiamine monophosphate kinase; Provisional; Region: PRK05731 573235001339 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 573235001340 ATP binding site [chemical binding]; other site 573235001341 dimerization interface [polypeptide binding]; other site 573235001342 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 573235001343 tetramer interfaces [polypeptide binding]; other site 573235001344 binuclear metal-binding site [ion binding]; other site 573235001345 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 573235001346 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 573235001347 active site 573235001348 catalytic tetrad [active] 573235001349 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 573235001350 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 573235001351 TPP-binding site; other site 573235001352 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 573235001353 PYR/PP interface [polypeptide binding]; other site 573235001354 dimer interface [polypeptide binding]; other site 573235001355 TPP binding site [chemical binding]; other site 573235001356 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 573235001357 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 573235001358 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 573235001359 substrate binding pocket [chemical binding]; other site 573235001360 chain length determination region; other site 573235001361 substrate-Mg2+ binding site; other site 573235001362 catalytic residues [active] 573235001363 aspartate-rich region 1; other site 573235001364 active site lid residues [active] 573235001365 aspartate-rich region 2; other site 573235001366 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 573235001367 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 573235001368 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 573235001369 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 573235001370 Ligand Binding Site [chemical binding]; other site 573235001371 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 573235001372 active site residue [active] 573235001373 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 573235001374 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 573235001375 conserved cys residue [active] 573235001376 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 573235001377 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 573235001378 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 573235001379 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 573235001380 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 573235001381 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235001382 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573235001383 putative substrate translocation pore; other site 573235001384 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 573235001385 Sel1 repeat; Region: Sel1; cl02723 573235001386 Sel1-like repeats; Region: SEL1; smart00671 573235001387 Sel1-like repeats; Region: SEL1; smart00671 573235001388 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 573235001389 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 573235001390 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 573235001391 UbiA prenyltransferase family; Region: UbiA; pfam01040 573235001392 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 573235001393 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 573235001394 Subunit I/III interface [polypeptide binding]; other site 573235001395 Subunit III/IV interface [polypeptide binding]; other site 573235001396 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 573235001397 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 573235001398 D-pathway; other site 573235001399 Putative ubiquinol binding site [chemical binding]; other site 573235001400 Low-spin heme (heme b) binding site [chemical binding]; other site 573235001401 Putative water exit pathway; other site 573235001402 Binuclear center (heme o3/CuB) [ion binding]; other site 573235001403 K-pathway; other site 573235001404 Putative proton exit pathway; other site 573235001405 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 573235001406 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 573235001407 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 573235001408 muropeptide transporter; Reviewed; Region: ampG; PRK11902 573235001409 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235001410 putative substrate translocation pore; other site 573235001411 hypothetical protein; Provisional; Region: PRK11627 573235001412 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 573235001413 transcriptional regulator BolA; Provisional; Region: PRK11628 573235001414 trigger factor; Provisional; Region: tig; PRK01490 573235001415 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 573235001416 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 573235001417 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 573235001418 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 573235001419 oligomer interface [polypeptide binding]; other site 573235001420 active site residues [active] 573235001421 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 573235001422 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 573235001423 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573235001424 Walker A motif; other site 573235001425 ATP binding site [chemical binding]; other site 573235001426 Walker B motif; other site 573235001427 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 573235001428 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 573235001429 Found in ATP-dependent protease La (LON); Region: LON; smart00464 573235001430 Found in ATP-dependent protease La (LON); Region: LON; smart00464 573235001431 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573235001432 Walker A motif; other site 573235001433 ATP binding site [chemical binding]; other site 573235001434 Walker B motif; other site 573235001435 arginine finger; other site 573235001436 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 573235001437 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 573235001438 IHF dimer interface [polypeptide binding]; other site 573235001439 IHF - DNA interface [nucleotide binding]; other site 573235001440 periplasmic folding chaperone; Provisional; Region: PRK10788 573235001441 SurA N-terminal domain; Region: SurA_N_3; cl07813 573235001442 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 573235001443 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 573235001444 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 573235001445 active site 573235001446 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 573235001447 Ligand Binding Site [chemical binding]; other site 573235001448 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 573235001449 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 573235001450 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 573235001451 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 573235001452 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573235001453 active site 573235001454 motif I; other site 573235001455 motif II; other site 573235001456 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 573235001457 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 573235001458 putative DNA binding site [nucleotide binding]; other site 573235001459 putative Zn2+ binding site [ion binding]; other site 573235001460 AsnC family; Region: AsnC_trans_reg; pfam01037 573235001461 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573235001462 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 573235001463 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573235001464 Walker A/P-loop; other site 573235001465 ATP binding site [chemical binding]; other site 573235001466 Q-loop/lid; other site 573235001467 ABC transporter signature motif; other site 573235001468 Walker B; other site 573235001469 D-loop; other site 573235001470 H-loop/switch region; other site 573235001471 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 573235001472 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573235001473 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 573235001474 Walker A/P-loop; other site 573235001475 ATP binding site [chemical binding]; other site 573235001476 Q-loop/lid; other site 573235001477 ABC transporter signature motif; other site 573235001478 Walker B; other site 573235001479 D-loop; other site 573235001480 H-loop/switch region; other site 573235001481 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 573235001482 Nitrogen regulatory protein P-II; Region: P-II; smart00938 573235001483 ammonium transporter; Provisional; Region: PRK10666 573235001484 acyl-CoA thioesterase II; Provisional; Region: PRK10526 573235001485 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 573235001486 active site 573235001487 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 573235001488 catalytic triad [active] 573235001489 dimer interface [polypeptide binding]; other site 573235001490 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 573235001491 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 573235001492 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 573235001493 DNA binding site [nucleotide binding] 573235001494 active site 573235001495 Uncharacterized conserved protein [Function unknown]; Region: COG5507 573235001496 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 573235001497 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 573235001498 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 573235001499 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 573235001500 maltose O-acetyltransferase; Provisional; Region: PRK10092 573235001501 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 573235001502 active site 573235001503 substrate binding site [chemical binding]; other site 573235001504 trimer interface [polypeptide binding]; other site 573235001505 CoA binding site [chemical binding]; other site 573235001506 gene expression modulator; Provisional; Region: PRK10945 573235001507 Biofilm formation regulator YbaJ; Region: YbaJ; pfam10757 573235001508 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 573235001509 Protein export membrane protein; Region: SecD_SecF; cl14618 573235001510 Protein export membrane protein; Region: SecD_SecF; cl14618 573235001511 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 573235001512 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 573235001513 HlyD family secretion protein; Region: HlyD_3; pfam13437 573235001514 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 573235001515 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573235001516 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 573235001517 hypothetical protein; Provisional; Region: PRK11281 573235001518 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 573235001519 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 573235001520 Mechanosensitive ion channel; Region: MS_channel; pfam00924 573235001521 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 573235001522 Transposase; Region: DEDD_Tnp_IS110; pfam01548 573235001523 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 573235001524 hypothetical protein; Provisional; Region: PRK11038 573235001525 primosomal replication protein N''; Provisional; Region: PRK10093 573235001526 hypothetical protein; Provisional; Region: PRK10527 573235001527 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 573235001528 active site 573235001529 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 573235001530 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573235001531 Walker A motif; other site 573235001532 ATP binding site [chemical binding]; other site 573235001533 Walker B motif; other site 573235001534 DNA polymerase III subunit delta'; Validated; Region: PRK08485 573235001535 arginine finger; other site 573235001536 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 573235001537 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 573235001538 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 573235001539 hypothetical protein; Validated; Region: PRK00153 573235001540 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecR; COG0353 573235001541 RecR protein; Region: RecR; pfam02132 573235001542 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 573235001543 putative active site [active] 573235001544 putative metal-binding site [ion binding]; other site 573235001545 tetramer interface [polypeptide binding]; other site 573235001546 heat shock protein 90; Provisional; Region: PRK05218 573235001547 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573235001548 ATP binding site [chemical binding]; other site 573235001549 Mg2+ binding site [ion binding]; other site 573235001550 G-X-G motif; other site 573235001551 adenylate kinase; Reviewed; Region: adk; PRK00279 573235001552 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 573235001553 AMP-binding site [chemical binding]; other site 573235001554 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 573235001555 ferrochelatase; Region: hemH; TIGR00109 573235001556 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 573235001557 C-terminal domain interface [polypeptide binding]; other site 573235001558 active site 573235001559 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 573235001560 active site 573235001561 N-terminal domain interface [polypeptide binding]; other site 573235001562 acetyl esterase; Provisional; Region: PRK10162 573235001563 inosine/guanosine kinase; Provisional; Region: PRK15074 573235001564 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 573235001565 putative cation:proton antiport protein; Provisional; Region: PRK10669 573235001566 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 573235001567 TrkA-N domain; Region: TrkA_N; pfam02254 573235001568 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235001569 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573235001570 putative substrate translocation pore; other site 573235001571 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 573235001572 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 573235001573 active site 573235001574 metal binding site [ion binding]; metal-binding site 573235001575 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 573235001576 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 573235001577 putative deacylase active site [active] 573235001578 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 573235001579 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 573235001580 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573235001581 sequence-specific DNA binding site [nucleotide binding]; other site 573235001582 salt bridge; other site 573235001583 copper exporting ATPase; Provisional; Region: copA; PRK10671 573235001584 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 573235001585 metal-binding site [ion binding] 573235001586 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 573235001587 metal-binding site [ion binding] 573235001588 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 573235001589 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573235001590 motif II; other site 573235001591 glutaminase; Reviewed; Region: PRK12356 573235001592 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 573235001593 amino acid transporter; Region: 2A0306; TIGR00909 573235001594 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 573235001595 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 573235001596 DNA binding residues [nucleotide binding] 573235001597 dimer interface [polypeptide binding]; other site 573235001598 copper binding site [ion binding]; other site 573235001599 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 573235001600 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 573235001601 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 573235001602 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 573235001603 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573235001604 Walker A/P-loop; other site 573235001605 ATP binding site [chemical binding]; other site 573235001606 Q-loop/lid; other site 573235001607 ABC transporter signature motif; other site 573235001608 Walker B; other site 573235001609 D-loop; other site 573235001610 H-loop/switch region; other site 573235001611 Uncharacterized protein family (UPF0014); Region: UPF0014; pfam03649 573235001612 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 573235001613 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 573235001614 oxidoreductase; Provisional; Region: PRK08017 573235001615 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 573235001616 NADP binding site [chemical binding]; other site 573235001617 active site 573235001618 steroid binding site; other site 573235001619 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 573235001620 active site 573235001621 catalytic triad [active] 573235001622 oxyanion hole [active] 573235001623 switch loop; other site 573235001624 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 573235001625 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 573235001626 Walker A/P-loop; other site 573235001627 ATP binding site [chemical binding]; other site 573235001628 Q-loop/lid; other site 573235001629 ABC transporter signature motif; other site 573235001630 Walker B; other site 573235001631 D-loop; other site 573235001632 H-loop/switch region; other site 573235001633 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 573235001634 FtsX-like permease family; Region: FtsX; pfam02687 573235001635 FtsX-like permease family; Region: FtsX; pfam02687 573235001636 RhsD core protein with extension, C-terminal part truncated 573235001637 conserved predicted protein, N-terminal fragment 573235001638 conserved predicted protein, N-terminal fragment 573235001639 Winged helix-turn helix; Region: HTH_29; pfam13551 573235001640 Helix-turn-helix domain; Region: HTH_28; pfam13518 573235001641 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 573235001642 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 573235001643 active site residue [active] 573235001644 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 573235001645 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573235001646 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 573235001647 dimerization interface [polypeptide binding]; other site 573235001648 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 573235001649 ureidoglycolate hydrolase; Provisional; Region: PRK03606 573235001650 DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163 573235001651 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 573235001652 Bacterial transcriptional regulator; Region: IclR; pfam01614 573235001653 glyoxylate carboligase; Provisional; Region: PRK11269 573235001654 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 573235001655 PYR/PP interface [polypeptide binding]; other site 573235001656 dimer interface [polypeptide binding]; other site 573235001657 TPP binding site [chemical binding]; other site 573235001658 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 573235001659 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 573235001660 TPP-binding site [chemical binding]; other site 573235001661 hydroxypyruvate isomerase; Provisional; Region: PRK09997 573235001662 tartronate semialdehyde reductase; Provisional; Region: PRK15059 573235001663 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 573235001664 nucleobase-cation-symport-1 (NCS1) transporters; solute-binding domain; Region: SLC-NCS1sbd; cd10323 573235001665 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 573235001666 Na binding site [ion binding]; other site 573235001667 substrate binding site [chemical binding]; other site 573235001668 allantoinase; Provisional; Region: PRK08044 573235001669 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 573235001670 active site 573235001671 predicted uracil/xanthine transporter, N-terminal part 573235001672 predicted uracil/xanthine transporter, C-terminal part 573235001673 glycerate kinase II; Provisional; Region: PRK09932 573235001674 Uncharacterized protein, possibly involved in glyoxylate utilization [General function prediction only]; Region: GlxB; COG3257 573235001675 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 573235001676 Cupin domain; Region: Cupin_2; cl17218 573235001677 allantoate amidohydrolase; Region: AllC; TIGR03176 573235001678 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 573235001679 active site 573235001680 metal binding site [ion binding]; metal-binding site 573235001681 dimer interface [polypeptide binding]; other site 573235001682 ureidoglycolate dehydrogenase; Provisional; Region: PRK15025 573235001683 membrane protein FdrA; Validated; Region: PRK06091 573235001684 CoA binding domain; Region: CoA_binding; pfam02629 573235001685 CoA-ligase; Region: Ligase_CoA; pfam00549 573235001686 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 573235001687 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 573235001688 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 573235001689 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 573235001690 putative substrate binding site [chemical binding]; other site 573235001691 nucleotide binding site [chemical binding]; other site 573235001692 nucleotide binding site [chemical binding]; other site 573235001693 homodimer interface [polypeptide binding]; other site 573235001694 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 573235001695 ATP-grasp domain; Region: ATP-grasp; pfam02222 573235001696 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 573235001697 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 573235001698 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 573235001699 putative active site [active] 573235001700 putative metal binding site [ion binding]; other site 573235001701 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 573235001702 substrate binding site [chemical binding]; other site 573235001703 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 573235001704 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 573235001705 active site 573235001706 HIGH motif; other site 573235001707 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 573235001708 KMSKS motif; other site 573235001709 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 573235001710 tRNA binding surface [nucleotide binding]; other site 573235001711 anticodon binding site; other site 573235001712 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 573235001713 ribosome-associated protein; Provisional; Region: PRK11507 573235001714 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 573235001715 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 573235001716 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 573235001717 homodimer interface [polypeptide binding]; other site 573235001718 NADP binding site [chemical binding]; other site 573235001719 substrate binding site [chemical binding]; other site 573235001720 type-1 fimbrial protein subunit A; Provisional; Region: PRK15194 573235001721 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 573235001722 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 573235001723 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 573235001724 outer membrane usher protein FimD; Provisional; Region: PRK15198 573235001725 PapC N-terminal domain; Region: PapC_N; pfam13954 573235001726 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 573235001727 PapC C-terminal domain; Region: PapC_C; pfam13953 573235001728 fimbrial-like adhesin; Provisional; Region: fimH; PRK15199 573235001729 fimbrial-like adhesin protein SfmF; Provisional; Region: PRK09934 573235001730 transcriptional regulator FimZ; Provisional; Region: PRK09935 573235001731 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573235001732 active site 573235001733 phosphorylation site [posttranslational modification] 573235001734 intermolecular recognition site; other site 573235001735 dimerization interface [polypeptide binding]; other site 573235001736 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573235001737 DNA binding residues [nucleotide binding] 573235001738 dimerization interface [polypeptide binding]; other site 573235001739 Prophage ECO26_P01, lambda-like phage 573235001740 P22-like integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial and phage integrases, including those similar to phage P22-like integrases, DLP12 and APSE-1; Region: INT_P22_C; cd01192 573235001741 Int/Topo IB signature motif; other site 573235001742 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 573235001743 DksA-like zinc finger domain containing protein; Region: PHA00080 573235001744 Protein of unknown function (DUF1382); Region: DUF1382; pfam07131 573235001745 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 573235001746 phage recombination protein Bet; Region: bet_lambda; TIGR01913 573235001747 Host-nuclease inhibitor protein Gam; Region: Gam; pfam06064 573235001748 FtsZ inhibitor protein; Reviewed; Region: kil; PRK11354 573235001749 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573235001750 non-specific DNA binding site [nucleotide binding]; other site 573235001751 salt bridge; other site 573235001752 Predicted transcriptional regulator [Transcription]; Region: COG2932 573235001753 sequence-specific DNA binding site [nucleotide binding]; other site 573235001754 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 573235001755 Catalytic site [active] 573235001756 Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197 573235001757 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 573235001758 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 573235001759 Replication protein P; Region: Phage_lambda_P; pfam06992 573235001760 BRO family, N-terminal domain; Region: Bro-N; smart01040 573235001761 P22AR C-terminal domain; Region: P22_AR_C; pfam10548 573235001762 HEPN domain; Region: HEPN; cl00824 573235001763 hypothetical protein; Provisional; Region: PRK09741 573235001764 Protein of unknown function (DUF1364); Region: DUF1364; pfam07102 573235001765 endodeoxyribonuclease RUS; Reviewed; Region: PRK09786 573235001766 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 573235001767 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 573235001768 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 573235001769 trimer interface [polypeptide binding]; other site 573235001770 eyelet of channel; other site 573235001771 Lysis protein S; Region: Lysis_S; pfam04971 573235001772 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 573235001773 catalytic residues [active] 573235001774 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 573235001775 Lipoprotein Rz1 precursor; Region: Rz1; pfam06085 573235001776 Bor protein; Region: Lambda_Bor; pfam06291 573235001777 putative transposase OrfB; Reviewed; Region: PHA02517 573235001778 HTH-like domain; Region: HTH_21; pfam13276 573235001779 Integrase core domain; Region: rve; pfam00665 573235001780 Integrase core domain; Region: rve_3; pfam13683 573235001781 Transposase; Region: HTH_Tnp_1; cl17663 573235001782 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 573235001783 Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471 573235001784 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 573235001785 gpW; Region: gpW; pfam02831 573235001786 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 573235001787 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 573235001788 Prophage ECO26_P01; predicted minor capsid protein, N-terminal fragment 573235001789 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 573235001790 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 573235001791 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573235001792 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 573235001793 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 573235001794 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 573235001795 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573235001796 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 573235001797 Transposase; Region: HTH_Tnp_1; pfam01527 573235001798 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 573235001799 Prophage ECO26_P01; predicted minor capsid protein, C-terminal fragment 573235001800 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 573235001801 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 573235001802 DNA packaging protein FI; Region: Packaging_FI; pfam14000 573235001803 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 573235001804 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 573235001805 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 573235001806 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 573235001807 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 573235001808 phage minor tail protein G; Region: phage_lambda_G; TIGR01674 573235001809 Minor tail protein T; Region: Phage_tail_T; pfam06223 573235001810 Phage-related minor tail protein [Function unknown]; Region: COG5281 573235001811 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 573235001812 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 573235001813 Phage-related protein [Function unknown]; Region: COG4718 573235001814 Phage-related protein [Function unknown]; Region: gp18; COG4672 573235001815 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 573235001816 MPN+ (JAMM) motif; other site 573235001817 Zinc-binding site [ion binding]; other site 573235001818 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 573235001819 NlpC/P60 family; Region: NLPC_P60; cl17555 573235001820 Phage-related protein, tail component [Function unknown]; Region: COG4723 573235001821 Phage-related protein, tail component [Function unknown]; Region: COG4733 573235001822 Putative phage tail protein; Region: Phage-tail_3; pfam13550 573235001823 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 573235001824 Fibronectin type III protein; Region: DUF3672; pfam12421 573235001825 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 573235001826 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 573235001827 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 573235001828 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 573235001829 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 573235001830 Phage Tail Collar Domain; Region: Collar; pfam07484 573235001831 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 573235001832 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 573235001833 Methyltransferase domain; Region: Methyltransf_31; pfam13847 573235001834 Methyltransferase domain; Region: Methyltransf_12; pfam08242 573235001835 S-adenosylmethionine binding site [chemical binding]; other site 573235001836 Prophage ECO26_P01; predicted tail fiber assembly protein, C-terminal fragment 573235001837 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 573235001838 TAP-like protein; Region: Abhydrolase_4; pfam08386 573235001839 outer membrane protease; Reviewed; Region: PRK10993 573235001840 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 573235001841 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573235001842 hypothetical protein; Provisional; Region: PRK09936 573235001843 bacteriophage N4 receptor, outer membrane subunit; Provisional; Region: PRK09782 573235001844 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573235001845 TPR motif; other site 573235001846 binding surface 573235001847 Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283 573235001848 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 573235001849 active site 573235001850 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 573235001851 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 573235001852 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 573235001853 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 573235001854 Transposase [DNA replication, recombination, and repair]; Region: COG5433 573235001855 Transposase [DNA replication, recombination, and repair]; Region: COG5433 573235001856 Rhs core protein, central part 573235001857 RhsK core protein with extension, C-terminal part degraded 573235001858 Uncharacterized conserved protein [Function unknown]; Region: COG5435 573235001859 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 573235001860 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 573235001861 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 573235001862 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 573235001863 sensor kinase CusS; Provisional; Region: PRK09835 573235001864 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573235001865 dimerization interface [polypeptide binding]; other site 573235001866 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573235001867 dimer interface [polypeptide binding]; other site 573235001868 phosphorylation site [posttranslational modification] 573235001869 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573235001870 ATP binding site [chemical binding]; other site 573235001871 Mg2+ binding site [ion binding]; other site 573235001872 G-X-G motif; other site 573235001873 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 573235001874 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573235001875 active site 573235001876 phosphorylation site [posttranslational modification] 573235001877 intermolecular recognition site; other site 573235001878 dimerization interface [polypeptide binding]; other site 573235001879 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573235001880 DNA binding site [nucleotide binding] 573235001881 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 573235001882 periplasmic copper-binding protein; Provisional; Region: PRK09838 573235001883 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 573235001884 HlyD family secretion protein; Region: HlyD_3; pfam13437 573235001885 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 573235001886 phenylalanine transporter; Provisional; Region: PRK10249 573235001887 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 573235001888 Mechanosensitive ion channel; Region: MS_channel; pfam00924 573235001889 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 573235001890 dimer interface [polypeptide binding]; other site 573235001891 FMN binding site [chemical binding]; other site 573235001892 hypothetical protein; Provisional; Region: PRK10250 573235001893 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 573235001894 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 573235001895 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 573235001896 Hok/gef family; Region: HOK_GEF; pfam01848 573235001897 Hok/gef family; Region: HOK_GEF; pfam01848 573235001898 Hok/gef family; Region: HOK_GEF; pfam01848 573235001899 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 573235001900 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 573235001901 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 573235001902 outer membrane receptor FepA; Provisional; Region: PRK13524 573235001903 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 573235001904 N-terminal plug; other site 573235001905 ligand-binding site [chemical binding]; other site 573235001906 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 573235001907 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 573235001908 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 573235001909 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 573235001910 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 573235001911 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 573235001912 acyl-activating enzyme (AAE) consensus motif; other site 573235001913 AMP binding site [chemical binding]; other site 573235001914 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 573235001915 LPS O-antigen length regulator; Provisional; Region: PRK10381 573235001916 Chain length determinant protein; Region: Wzz; pfam02706 573235001917 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 573235001918 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 573235001919 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 573235001920 Walker A/P-loop; other site 573235001921 ATP binding site [chemical binding]; other site 573235001922 Q-loop/lid; other site 573235001923 ABC transporter signature motif; other site 573235001924 Walker B; other site 573235001925 D-loop; other site 573235001926 H-loop/switch region; other site 573235001927 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 573235001928 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 573235001929 ABC-ATPase subunit interface; other site 573235001930 dimer interface [polypeptide binding]; other site 573235001931 putative PBP binding regions; other site 573235001932 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 573235001933 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 573235001934 ABC-ATPase subunit interface; other site 573235001935 dimer interface [polypeptide binding]; other site 573235001936 putative PBP binding regions; other site 573235001937 enterobactin exporter EntS; Provisional; Region: PRK10489 573235001938 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235001939 putative substrate translocation pore; other site 573235001940 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 573235001941 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 573235001942 siderophore binding site; other site 573235001943 isochorismate synthase EntC; Provisional; Region: PRK15016 573235001944 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 573235001945 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 573235001946 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 573235001947 acyl-activating enzyme (AAE) consensus motif; other site 573235001948 active site 573235001949 AMP binding site [chemical binding]; other site 573235001950 substrate binding site [chemical binding]; other site 573235001951 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 573235001952 hydrophobic substrate binding pocket; other site 573235001953 Isochorismatase family; Region: Isochorismatase; pfam00857 573235001954 active site 573235001955 conserved cis-peptide bond; other site 573235001956 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 573235001957 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 573235001958 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 573235001959 putative NAD(P) binding site [chemical binding]; other site 573235001960 active site 573235001961 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 573235001962 CoenzymeA binding site [chemical binding]; other site 573235001963 subunit interaction site [polypeptide binding]; other site 573235001964 PHB binding site; other site 573235001965 carbon starvation protein A; Provisional; Region: PRK15015 573235001966 Carbon starvation protein CstA; Region: CstA; pfam02554 573235001967 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 573235001968 Uncharacterized small protein [Function unknown]; Region: COG2879 573235001969 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 573235001970 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 573235001971 putative active site [active] 573235001972 metal binding site [ion binding]; metal-binding site 573235001973 methionine aminotransferase; Validated; Region: PRK09082 573235001974 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573235001975 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573235001976 homodimer interface [polypeptide binding]; other site 573235001977 catalytic residue [active] 573235001978 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 573235001979 ParB-like nuclease domain; Region: ParBc; pfam02195 573235001980 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 573235001981 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 573235001982 Active Sites [active] 573235001983 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 573235001984 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 573235001985 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573235001986 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 573235001987 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 573235001988 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 573235001989 dimerization domain [polypeptide binding]; other site 573235001990 dimer interface [polypeptide binding]; other site 573235001991 catalytic residues [active] 573235001992 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 573235001993 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 573235001994 dimer interface [polypeptide binding]; other site 573235001995 decamer (pentamer of dimers) interface [polypeptide binding]; other site 573235001996 catalytic triad [active] 573235001997 peroxidatic and resolving cysteines [active] 573235001998 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 573235001999 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 573235002000 catalytic residue [active] 573235002001 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 573235002002 catalytic residues [active] 573235002003 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 573235002004 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 573235002005 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 573235002006 Ligand Binding Site [chemical binding]; other site 573235002007 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 573235002008 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 573235002009 NAD binding site [chemical binding]; other site 573235002010 catalytic Zn binding site [ion binding]; other site 573235002011 structural Zn binding site [ion binding]; other site 573235002012 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 573235002013 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 573235002014 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 573235002015 B1 nucleotide binding pocket [chemical binding]; other site 573235002016 B2 nucleotide binding pocket [chemical binding]; other site 573235002017 CAS motifs; other site 573235002018 active site 573235002019 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 573235002020 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 573235002021 transmembrane helices; other site 573235002022 triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096 573235002023 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 573235002024 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 573235002025 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 573235002026 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 573235002027 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 573235002028 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 573235002029 putative active site [active] 573235002030 (T/H)XGH motif; other site 573235002031 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 573235002032 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573235002033 putative active site [active] 573235002034 heme pocket [chemical binding]; other site 573235002035 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573235002036 ATP binding site [chemical binding]; other site 573235002037 Mg2+ binding site [ion binding]; other site 573235002038 G-X-G motif; other site 573235002039 two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046 573235002040 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573235002041 active site 573235002042 phosphorylation site [posttranslational modification] 573235002043 intermolecular recognition site; other site 573235002044 dimerization interface [polypeptide binding]; other site 573235002045 Transcriptional regulator; Region: CitT; pfam12431 573235002046 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 573235002047 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 573235002048 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 573235002049 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 573235002050 DNA-binding site [nucleotide binding]; DNA binding site 573235002051 RNA-binding motif; other site 573235002052 chromosome condensation membrane protein; Provisional; Region: PRK14196 573235002053 Predicted amidohydrolase [General function prediction only]; Region: COG0388 573235002054 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 573235002055 putative active site [active] 573235002056 catalytic triad [active] 573235002057 putative dimer interface [polypeptide binding]; other site 573235002058 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 573235002059 lipoyl synthase; Provisional; Region: PRK05481 573235002060 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573235002061 FeS/SAM binding site; other site 573235002062 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 573235002063 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573235002064 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 573235002065 substrate binding pocket [chemical binding]; other site 573235002066 dimerization interface [polypeptide binding]; other site 573235002067 lipoate-protein ligase B; Provisional; Region: PRK14342 573235002068 hypothetical protein; Provisional; Region: PRK04998 573235002069 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 573235002070 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 573235002071 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 573235002072 rare lipoprotein A; Provisional; Region: PRK10672 573235002073 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 573235002074 Sporulation related domain; Region: SPOR; pfam05036 573235002075 cell wall shape-determining protein; Provisional; Region: PRK10794 573235002076 penicillin-binding protein 2; Provisional; Region: PRK10795 573235002077 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 573235002078 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 573235002079 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 573235002080 ribosome-associated protein; Provisional; Region: PRK11538 573235002081 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 573235002082 catalytic core [active] 573235002083 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 573235002084 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 573235002085 active site 573235002086 (T/H)XGH motif; other site 573235002087 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 573235002088 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 573235002089 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 573235002090 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 573235002091 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 573235002092 HIGH motif; other site 573235002093 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 573235002094 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 573235002095 active site 573235002096 KMSKS motif; other site 573235002097 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 573235002098 tRNA binding surface [nucleotide binding]; other site 573235002099 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 573235002100 hypothetical protein; Provisional; Region: PRK11032 573235002101 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 573235002102 Sel1-like repeats; Region: SEL1; smart00671 573235002103 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 573235002104 Sel1-like repeats; Region: SEL1; smart00671 573235002105 Sel1-like repeats; Region: SEL1; smart00671 573235002106 Sel1-like repeats; Region: SEL1; smart00671 573235002107 Sel1-like repeats; Region: SEL1; smart00671 573235002108 Sel1-like repeats; Region: SEL1; smart00671 573235002109 Sel1-like repeats; Region: SEL1; smart00671 573235002110 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 573235002111 predicted DnaJ family chaperone DjlB, N-terminal part 573235002112 predicted DnaJ family chaperone DjlB, C-terminal part 573235002113 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 573235002114 Sel1-like repeats; Region: SEL1; smart00671 573235002115 Sel1-like repeats; Region: SEL1; smart00671 573235002116 Sel1-like repeats; Region: SEL1; smart00671 573235002117 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 573235002118 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 573235002119 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 573235002120 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 573235002121 nucleotide binding site [chemical binding]; other site 573235002122 putative NEF/HSP70 interaction site [polypeptide binding]; other site 573235002123 SBD interface [polypeptide binding]; other site 573235002124 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 573235002125 active site 573235002126 tetramer interface [polypeptide binding]; other site 573235002127 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 573235002128 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 573235002129 Walker A/P-loop; other site 573235002130 ATP binding site [chemical binding]; other site 573235002131 Q-loop/lid; other site 573235002132 ABC transporter signature motif; other site 573235002133 Walker B; other site 573235002134 D-loop; other site 573235002135 H-loop/switch region; other site 573235002136 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 573235002137 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573235002138 dimer interface [polypeptide binding]; other site 573235002139 conserved gate region; other site 573235002140 putative PBP binding loops; other site 573235002141 ABC-ATPase subunit interface; other site 573235002142 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 573235002143 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573235002144 dimer interface [polypeptide binding]; other site 573235002145 conserved gate region; other site 573235002146 putative PBP binding loops; other site 573235002147 ABC-ATPase subunit interface; other site 573235002148 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 573235002149 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 573235002150 substrate binding pocket [chemical binding]; other site 573235002151 membrane-bound complex binding site; other site 573235002152 hinge residues; other site 573235002153 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 573235002154 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 573235002155 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 573235002156 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 573235002157 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 573235002158 putative active site [active] 573235002159 catalytic triad [active] 573235002160 putative dimer interface [polypeptide binding]; other site 573235002161 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 573235002162 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 573235002163 Transporter associated domain; Region: CorC_HlyC; smart01091 573235002164 metal-binding heat shock protein; Provisional; Region: PRK00016 573235002165 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 573235002166 PhoH-like protein; Region: PhoH; pfam02562 573235002167 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 573235002168 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 573235002169 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573235002170 FeS/SAM binding site; other site 573235002171 TRAM domain; Region: TRAM; pfam01938 573235002172 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 573235002173 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 573235002174 asparagine synthetase B; Provisional; Region: asnB; PRK09431 573235002175 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 573235002176 active site 573235002177 dimer interface [polypeptide binding]; other site 573235002178 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 573235002179 Ligand Binding Site [chemical binding]; other site 573235002180 Molecular Tunnel; other site 573235002181 UMP phosphatase; Provisional; Region: PRK10444 573235002182 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573235002183 active site 573235002184 motif I; other site 573235002185 motif II; other site 573235002186 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573235002187 MarR family; Region: MarR; pfam01047 573235002188 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 573235002189 ROK family; Region: ROK; pfam00480 573235002190 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 573235002191 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 573235002192 active site 573235002193 dimer interface [polypeptide binding]; other site 573235002194 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 573235002195 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 573235002196 active site 573235002197 trimer interface [polypeptide binding]; other site 573235002198 allosteric site; other site 573235002199 active site lid [active] 573235002200 hexamer (dimer of trimers) interface [polypeptide binding]; other site 573235002201 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 573235002202 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 573235002203 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 573235002204 active site turn [active] 573235002205 phosphorylation site [posttranslational modification] 573235002206 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 573235002207 HPr interaction site; other site 573235002208 glycerol kinase (GK) interaction site [polypeptide binding]; other site 573235002209 active site 573235002210 phosphorylation site [posttranslational modification] 573235002211 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 573235002212 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 573235002213 active site 573235002214 HIGH motif; other site 573235002215 nucleotide binding site [chemical binding]; other site 573235002216 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 573235002217 KMSKS motif; other site 573235002218 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 573235002219 outer membrane porin, OprD family; Region: OprD; pfam03573 573235002220 YbfN-like lipoprotein; Region: YbfN; pfam13982 573235002221 ferric uptake regulator; Provisional; Region: fur; PRK09462 573235002222 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 573235002223 metal binding site 2 [ion binding]; metal-binding site 573235002224 putative DNA binding helix; other site 573235002225 metal binding site 1 [ion binding]; metal-binding site 573235002226 dimer interface [polypeptide binding]; other site 573235002227 structural Zn2+ binding site [ion binding]; other site 573235002228 ryhB-regulated fur leader peptide; Provisional; Region: PRK14761 573235002229 flavodoxin FldA; Validated; Region: PRK09267 573235002230 LexA regulated protein; Provisional; Region: PRK11675 573235002231 acyl-CoA esterase; Provisional; Region: PRK10673 573235002232 PGAP1-like protein; Region: PGAP1; pfam07819 573235002233 replication initiation regulator SeqA; Provisional; Region: PRK11187 573235002234 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 573235002235 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 573235002236 active site 573235002237 substrate binding site [chemical binding]; other site 573235002238 metal binding site [ion binding]; metal-binding site 573235002239 putrescine transporter; Provisional; Region: potE; PRK10655 573235002240 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 573235002241 ornithine decarboxylase; Provisional; Region: PRK13578 573235002242 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 573235002243 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 573235002244 homodimer interface [polypeptide binding]; other site 573235002245 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573235002246 catalytic residue [active] 573235002247 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 573235002248 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 573235002249 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573235002250 active site 573235002251 phosphorylation site [posttranslational modification] 573235002252 intermolecular recognition site; other site 573235002253 dimerization interface [polypeptide binding]; other site 573235002254 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573235002255 DNA binding site [nucleotide binding] 573235002256 sensor protein KdpD; Provisional; Region: PRK10490 573235002257 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 573235002258 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 573235002259 Ligand Binding Site [chemical binding]; other site 573235002260 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 573235002261 GAF domain; Region: GAF_3; pfam13492 573235002262 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573235002263 dimer interface [polypeptide binding]; other site 573235002264 phosphorylation site [posttranslational modification] 573235002265 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573235002266 ATP binding site [chemical binding]; other site 573235002267 Mg2+ binding site [ion binding]; other site 573235002268 G-X-G motif; other site 573235002269 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 573235002270 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 573235002271 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 573235002272 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 573235002273 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 573235002274 PAAR motif; Region: PAAR_motif; cl15808 573235002275 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 573235002276 RHS Repeat; Region: RHS_repeat; pfam05593 573235002277 RHS Repeat; Region: RHS_repeat; pfam05593 573235002278 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 573235002279 RHS Repeat; Region: RHS_repeat; pfam05593 573235002280 RHS Repeat; Region: RHS_repeat; pfam05593 573235002281 RHS protein; Region: RHS; pfam03527 573235002282 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 573235002283 Rhs core protein with extension, C-terminal fragment 573235002284 RhsC, IS677, H repeat-associated protein, central part 573235002285 hypothetical protein; Provisional; Region: PRK10167 573235002286 Uncharacterized conserved protein [Function unknown]; Region: COG3272 573235002287 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 573235002288 DNA photolyase; Region: DNA_photolyase; pfam00875 573235002289 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 573235002290 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235002291 putative substrate translocation pore; other site 573235002292 POT family; Region: PTR2; pfam00854 573235002293 Uncharacterized conserved protein [Function unknown]; Region: COG0327 573235002294 metal-binding protein; Provisional; Region: PRK10799 573235002295 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 573235002296 sensor histidine kinase inhibitor, KipI family; Region: TIGR00370 573235002297 biotin-dependent carboxylase uncharacterized domain; Region: urea_amlyse_rel; TIGR00724 573235002298 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 573235002299 putative active site [active] 573235002300 endonuclease VIII; Provisional; Region: PRK10445 573235002301 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 573235002302 DNA binding site [nucleotide binding] 573235002303 catalytic residue [active] 573235002304 putative catalytic residues [active] 573235002305 H2TH interface [polypeptide binding]; other site 573235002306 intercalation triad [nucleotide binding]; other site 573235002307 substrate specificity determining residue; other site 573235002308 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 573235002309 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 573235002310 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 573235002311 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 573235002312 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 573235002313 Fimbrial protein; Region: Fimbrial; pfam00419 573235002314 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 573235002315 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 573235002316 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 573235002317 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 573235002318 PapC N-terminal domain; Region: PapC_N; pfam13954 573235002319 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 573235002320 PapC C-terminal domain; Region: PapC_C; pfam13953 573235002321 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 573235002322 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 573235002323 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 573235002324 dimer interface [polypeptide binding]; other site 573235002325 active site 573235002326 citrylCoA binding site [chemical binding]; other site 573235002327 NADH binding [chemical binding]; other site 573235002328 cationic pore residues; other site 573235002329 oxalacetate/citrate binding site [chemical binding]; other site 573235002330 coenzyme A binding site [chemical binding]; other site 573235002331 catalytic triad [active] 573235002332 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 573235002333 Iron-sulfur protein interface; other site 573235002334 proximal quinone binding site [chemical binding]; other site 573235002335 SdhD (CybS) interface [polypeptide binding]; other site 573235002336 proximal heme binding site [chemical binding]; other site 573235002337 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 573235002338 SdhC subunit interface [polypeptide binding]; other site 573235002339 proximal heme binding site [chemical binding]; other site 573235002340 cardiolipin binding site; other site 573235002341 Iron-sulfur protein interface; other site 573235002342 proximal quinone binding site [chemical binding]; other site 573235002343 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 573235002344 L-aspartate oxidase; Provisional; Region: PRK06175 573235002345 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 573235002346 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 573235002347 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 573235002348 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 573235002349 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 573235002350 TPP-binding site [chemical binding]; other site 573235002351 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 573235002352 dimer interface [polypeptide binding]; other site 573235002353 PYR/PP interface [polypeptide binding]; other site 573235002354 TPP binding site [chemical binding]; other site 573235002355 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 573235002356 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 573235002357 E3 interaction surface; other site 573235002358 lipoyl attachment site [posttranslational modification]; other site 573235002359 e3 binding domain; Region: E3_binding; pfam02817 573235002360 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 573235002361 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 573235002362 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 573235002363 CoA-ligase; Region: Ligase_CoA; pfam00549 573235002364 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 573235002365 CoA binding domain; Region: CoA_binding; smart00881 573235002366 CoA-ligase; Region: Ligase_CoA; pfam00549 573235002367 DNA-binding transcriptional repressor MngR; Provisional; Region: PRK09764 573235002368 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573235002369 DNA-binding site [nucleotide binding]; DNA binding site 573235002370 UTRA domain; Region: UTRA; pfam07702 573235002371 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 573235002372 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 573235002373 active site 573235002374 phosphorylation site [posttranslational modification] 573235002375 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 573235002376 active site 573235002377 P-loop; other site 573235002378 phosphorylation site [posttranslational modification] 573235002379 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 573235002380 alpha-mannosidase; Provisional; Region: PRK09819 573235002381 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 573235002382 active site 573235002383 metal binding site [ion binding]; metal-binding site 573235002384 catalytic site [active] 573235002385 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 573235002386 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 573235002387 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 573235002388 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 573235002389 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 573235002390 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 573235002391 hypothetical protein; Provisional; Region: PRK10588 573235002392 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 573235002393 active site 573235002394 colicin uptake protein TolQ; Provisional; Region: PRK10801 573235002395 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 573235002396 colicin uptake protein TolR; Provisional; Region: PRK11024 573235002397 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 573235002398 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 573235002399 TolA C-terminal; Region: TolA; pfam06519 573235002400 translocation protein TolB; Provisional; Region: tolB; PRK03629 573235002401 TolB amino-terminal domain; Region: TolB_N; pfam04052 573235002402 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 573235002403 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 573235002404 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 573235002405 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 573235002406 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 573235002407 ligand binding site [chemical binding]; other site 573235002408 tol-pal system protein YbgF; Provisional; Region: PRK10803 573235002409 Tetratricopeptide repeat; Region: TPR_6; pfam13174 573235002410 Tetratricopeptide repeat; Region: TPR_6; pfam13174 573235002411 quinolinate synthetase; Provisional; Region: PRK09375 573235002412 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 573235002413 zinc transporter ZitB; Provisional; Region: PRK03557 573235002414 YbgS-like protein; Region: YbgS; pfam13985 573235002415 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 573235002416 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 573235002417 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 573235002418 catalytic core [active] 573235002419 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 573235002420 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 573235002421 active site 573235002422 catalytic residues [active] 573235002423 galactokinase; Provisional; Region: PRK05101 573235002424 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 573235002425 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 573235002426 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 573235002427 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 573235002428 dimer interface [polypeptide binding]; other site 573235002429 active site 573235002430 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 573235002431 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 573235002432 NAD binding site [chemical binding]; other site 573235002433 homodimer interface [polypeptide binding]; other site 573235002434 active site 573235002435 substrate binding site [chemical binding]; other site 573235002436 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 573235002437 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 573235002438 Walker A/P-loop; other site 573235002439 ATP binding site [chemical binding]; other site 573235002440 Q-loop/lid; other site 573235002441 ABC transporter signature motif; other site 573235002442 Walker B; other site 573235002443 D-loop; other site 573235002444 H-loop/switch region; other site 573235002445 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573235002446 Walker A/P-loop; other site 573235002447 ATP binding site [chemical binding]; other site 573235002448 Q-loop/lid; other site 573235002449 ABC transporter signature motif; other site 573235002450 Walker B; other site 573235002451 D-loop; other site 573235002452 H-loop/switch region; other site 573235002453 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 573235002454 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 573235002455 molybdenum-pterin binding domain; Region: Mop; TIGR00638 573235002456 TOBE domain; Region: TOBE; pfam03459 573235002457 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 573235002458 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 573235002459 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 573235002460 substrate binding pocket [chemical binding]; other site 573235002461 membrane-bound complex binding site; other site 573235002462 hinge residues; other site 573235002463 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 573235002464 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573235002465 putative PBP binding loops; other site 573235002466 ABC-ATPase subunit interface; other site 573235002467 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 573235002468 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573235002469 Walker A/P-loop; other site 573235002470 ATP binding site [chemical binding]; other site 573235002471 Q-loop/lid; other site 573235002472 ABC transporter signature motif; other site 573235002473 Walker B; other site 573235002474 D-loop; other site 573235002475 H-loop/switch region; other site 573235002476 molybdenum-pterin binding domain; Region: Mop; TIGR00638 573235002477 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 573235002478 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573235002479 motif II; other site 573235002480 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573235002481 6-phosphogluconolactonase; Provisional; Region: PRK11028 573235002482 Transcriptional regulator [Transcription]; Region: LysR; COG0583 573235002483 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573235002484 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 573235002485 putative dimerization interface [polypeptide binding]; other site 573235002486 PrpF protein; Region: PrpF; pfam04303 573235002487 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 573235002488 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 573235002489 transmembrane helices; other site 573235002490 putative hydratase; Provisional; Region: PRK11413 573235002491 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 573235002492 substrate binding site [chemical binding]; other site 573235002493 ligand binding site [chemical binding]; other site 573235002494 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 573235002495 substrate binding site [chemical binding]; other site 573235002496 acyl-CoA thioesterase; Provisional; Region: PRK10531 573235002497 putative pectinesterase; Region: PLN02432; cl01911 573235002498 Prophage ECO26_P02, lambda-like phage 573235002499 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 573235002500 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 573235002501 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 573235002502 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 573235002503 dimer interface [polypeptide binding]; other site 573235002504 active site 573235002505 Int/Topo IB signature motif; other site 573235002506 Excisionase-like protein; Region: Exc; pfam07825 573235002507 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 573235002508 restriction alleviation protein, Lar family; Region: anti_R_Lar; TIGR03655 573235002509 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 573235002510 Protein of unknown function (DUF2856); Region: DUF2856; pfam11043 573235002511 ERF superfamily; Region: ERF; pfam04404 573235002512 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 573235002513 Transposase; Region: HTH_Tnp_1; pfam01527 573235002514 Prophage ECO26_P02; predicted transposase OrfB protein of insertion sequence IS600, C-terminal fragment 573235002515 Lambda Phage CIII; Region: Lambda_CIII; pfam02061 573235002516 Prophage ECO26_P02; regulatory protein CII, C-terminal part 573235002517 Prophage ECO26_P02; predicted replication protein, N-terminal fragment 573235002518 Prophage ECO26_P02; predicted replication protein, C-terminal fragment 573235002519 Replication protein P; Region: Phage_lambda_P; pfam06992 573235002520 NinB protein; Region: NinB; pfam05772 573235002521 putative transposase OrfB; Reviewed; Region: PHA02517 573235002522 HTH-like domain; Region: HTH_21; pfam13276 573235002523 Integrase core domain; Region: rve; pfam00665 573235002524 Integrase core domain; Region: rve_3; pfam13683 573235002525 Transposase; Region: HTH_Tnp_1; cl17663 573235002526 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 573235002527 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 573235002528 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 573235002529 Endodeoxyribonuclease RusA; Region: RusA; cl01885 573235002530 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3528 573235002531 Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323 573235002532 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 573235002533 Domain of unknown function (DUF303); Region: DUF303; pfam03629 573235002534 Lysis protein S; Region: Lysis_S; pfam04971 573235002535 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 573235002536 catalytic residues [active] 573235002537 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 573235002538 Lipoprotein Rz1 precursor; Region: Rz1; pfam06085 573235002539 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646 573235002540 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 573235002541 ORF11CD3 domain; Region: ORF11CD3; pfam10549 573235002542 Phage DNA packaging protein, Nu1 subunit of terminase [DNA replication, recombination, and repair]; Region: COG4220 573235002543 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 573235002544 gpW; Region: gpW; pfam02831 573235002545 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 573235002546 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 573235002547 Prophage ECO26_P02; predicted head protein/prohead protease, N-terminal fragment 573235002548 Transposase; Region: HTH_Tnp_1; pfam01527 573235002549 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 573235002550 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573235002551 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 573235002552 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 573235002553 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573235002554 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 573235002555 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 573235002556 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 573235002557 Prophage ECO26_P02; predicted minor tail protein, C-terminal fragment 573235002558 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 573235002559 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 573235002560 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894 573235002561 Minor tail protein T; Region: Phage_tail_T; cl05636 573235002562 Phage-related minor tail protein [Function unknown]; Region: COG5281 573235002563 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 573235002564 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 573235002565 Phage-related protein [Function unknown]; Region: COG4718 573235002566 Phage-related protein [Function unknown]; Region: gp18; COG4672 573235002567 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 573235002568 MPN+ (JAMM) motif; other site 573235002569 Zinc-binding site [ion binding]; other site 573235002570 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 573235002571 NlpC/P60 family; Region: NLPC_P60; cl17555 573235002572 Phage-related protein, tail component [Function unknown]; Region: COG4723 573235002573 Phage-related protein, tail component [Function unknown]; Region: COG4733 573235002574 Putative phage tail protein; Region: Phage-tail_3; pfam13550 573235002575 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 573235002576 Fibronectin type III protein; Region: DUF3672; pfam12421 573235002577 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 573235002578 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 573235002579 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 573235002580 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 573235002581 Prophage ECO26_P02; predicted tail fiber protein, C-terminal fragment 573235002582 Prophage ECO26_P02; Cycle-inhibiting factor Cif, non-functional due to a frame shift mutation 573235002583 Prophage ECO26_P02; part of site-specific recombinase, phage integrase family 573235002584 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 573235002585 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 573235002586 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573235002587 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 573235002588 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 573235002589 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 573235002590 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573235002591 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 573235002592 Transposase; Region: HTH_Tnp_1; pfam01527 573235002593 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 573235002594 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 573235002595 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 573235002596 substrate binding site [chemical binding]; other site 573235002597 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 573235002598 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 573235002599 inhibitor-cofactor binding pocket; inhibition site 573235002600 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573235002601 catalytic residue [active] 573235002602 biotin synthase; Provisional; Region: PRK15108 573235002603 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573235002604 FeS/SAM binding site; other site 573235002605 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 573235002606 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 573235002607 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 573235002608 substrate-cofactor binding pocket; other site 573235002609 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573235002610 catalytic residue [active] 573235002611 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 573235002612 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573235002613 S-adenosylmethionine binding site [chemical binding]; other site 573235002614 AAA domain; Region: AAA_26; pfam13500 573235002615 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 573235002616 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 573235002617 ADP binding site [chemical binding]; other site 573235002618 excinuclease ABC subunit B; Provisional; Region: PRK05298 573235002619 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573235002620 ATP binding site [chemical binding]; other site 573235002621 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573235002622 nucleotide binding region [chemical binding]; other site 573235002623 ATP-binding site [chemical binding]; other site 573235002624 Ultra-violet resistance protein B; Region: UvrB; pfam12344 573235002625 UvrB/uvrC motif; Region: UVR; pfam02151 573235002626 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 573235002627 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 573235002628 putative substrate binding pocket [chemical binding]; other site 573235002629 dimer interface [polypeptide binding]; other site 573235002630 phosphate binding site [ion binding]; other site 573235002631 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 573235002632 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573235002633 FeS/SAM binding site; other site 573235002634 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 573235002635 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 573235002636 MPT binding site; other site 573235002637 trimer interface [polypeptide binding]; other site 573235002638 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 573235002639 trimer interface [polypeptide binding]; other site 573235002640 dimer interface [polypeptide binding]; other site 573235002641 putative active site [active] 573235002642 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 573235002643 MoaE interaction surface [polypeptide binding]; other site 573235002644 MoeB interaction surface [polypeptide binding]; other site 573235002645 thiocarboxylated glycine; other site 573235002646 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 573235002647 MoaE homodimer interface [polypeptide binding]; other site 573235002648 MoaD interaction [polypeptide binding]; other site 573235002649 active site residues [active] 573235002650 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 573235002651 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 573235002652 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 573235002653 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 573235002654 Predicted integral membrane protein [Function unknown]; Region: COG0392 573235002655 cardiolipin synthase 2; Provisional; Region: PRK11263 573235002656 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 573235002657 putative active site [active] 573235002658 catalytic site [active] 573235002659 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 573235002660 putative active site [active] 573235002661 catalytic site [active] 573235002662 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 573235002663 putative catalytic site [active] 573235002664 putative metal binding site [ion binding]; other site 573235002665 putative phosphate binding site [ion binding]; other site 573235002666 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 573235002667 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 573235002668 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 573235002669 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 573235002670 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 573235002671 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 573235002672 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 573235002673 Walker A/P-loop; other site 573235002674 ATP binding site [chemical binding]; other site 573235002675 Q-loop/lid; other site 573235002676 ABC transporter signature motif; other site 573235002677 Walker B; other site 573235002678 D-loop; other site 573235002679 H-loop/switch region; other site 573235002680 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 573235002681 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 573235002682 Walker A/P-loop; other site 573235002683 ATP binding site [chemical binding]; other site 573235002684 Q-loop/lid; other site 573235002685 ABC transporter signature motif; other site 573235002686 Walker B; other site 573235002687 D-loop; other site 573235002688 H-loop/switch region; other site 573235002689 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 573235002690 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 573235002691 HlyD family secretion protein; Region: HlyD_3; pfam13437 573235002692 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 573235002693 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 573235002694 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 573235002695 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 573235002696 ATP binding site [chemical binding]; other site 573235002697 Mg++ binding site [ion binding]; other site 573235002698 motif III; other site 573235002699 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573235002700 nucleotide binding region [chemical binding]; other site 573235002701 ATP-binding site [chemical binding]; other site 573235002702 putative dehydrogenase; Provisional; Region: PRK10098 573235002703 glycosyl transferase family protein; Provisional; Region: PRK08136 573235002704 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 573235002705 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 573235002706 DEAD_2; Region: DEAD_2; pfam06733 573235002707 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 573235002708 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3236 573235002709 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 573235002710 Transposase; Region: DEDD_Tnp_IS110; pfam01548 573235002711 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 573235002712 hypothetical protein; Provisional; Region: PRK10259 573235002713 hypothetical protein; Provisional; Region: PRK11019 573235002714 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 573235002715 catecholate siderophore receptor Fiu; Provisional; Region: PRK09840 573235002716 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 573235002717 N-terminal plug; other site 573235002718 ligand-binding site [chemical binding]; other site 573235002719 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 573235002720 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 573235002721 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 573235002722 putative mechanosensitive channel protein; Provisional; Region: PRK11465 573235002723 Mechanosensitive ion channel; Region: MS_channel; pfam00924 573235002724 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 573235002725 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 573235002726 Walker A/P-loop; other site 573235002727 ATP binding site [chemical binding]; other site 573235002728 Q-loop/lid; other site 573235002729 ABC transporter signature motif; other site 573235002730 Walker B; other site 573235002731 D-loop; other site 573235002732 H-loop/switch region; other site 573235002733 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 573235002734 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573235002735 dimer interface [polypeptide binding]; other site 573235002736 conserved gate region; other site 573235002737 putative PBP binding loops; other site 573235002738 ABC-ATPase subunit interface; other site 573235002739 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 573235002740 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 573235002741 substrate binding pocket [chemical binding]; other site 573235002742 membrane-bound complex binding site; other site 573235002743 hinge residues; other site 573235002744 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 573235002745 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 573235002746 dimerization interface [polypeptide binding]; other site 573235002747 DPS ferroxidase diiron center [ion binding]; other site 573235002748 ion pore; other site 573235002749 threonine and homoserine efflux system; Provisional; Region: PRK10532 573235002750 EamA-like transporter family; Region: EamA; pfam00892 573235002751 outer membrane protein X; Provisional; Region: ompX; PRK09408 573235002752 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 573235002753 Sulfatase; Region: Sulfatase; pfam00884 573235002754 manganese transport regulator MntR; Provisional; Region: PRK11050 573235002755 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 573235002756 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 573235002757 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 573235002758 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 573235002759 transmembrane helices; other site 573235002760 L,D-transpeptidase; Provisional; Region: PRK10260 573235002761 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 573235002762 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 573235002763 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573235002764 Walker A/P-loop; other site 573235002765 ATP binding site [chemical binding]; other site 573235002766 Q-loop/lid; other site 573235002767 ABC transporter signature motif; other site 573235002768 Walker B; other site 573235002769 D-loop; other site 573235002770 H-loop/switch region; other site 573235002771 ABC transporter; Region: ABC_tran_2; pfam12848 573235002772 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 573235002773 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 573235002774 Transposase; Region: DEDD_Tnp_IS110; pfam01548 573235002775 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 573235002776 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 573235002777 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 573235002778 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573235002779 active site 573235002780 motif I; other site 573235002781 motif II; other site 573235002782 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573235002783 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 573235002784 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 573235002785 dimer interface [polypeptide binding]; other site 573235002786 active site 573235002787 glycine loop; other site 573235002788 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 573235002789 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 573235002790 active site 573235002791 intersubunit interactions; other site 573235002792 catalytic residue [active] 573235002793 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 573235002794 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 573235002795 ATP binding site [chemical binding]; other site 573235002796 substrate interface [chemical binding]; other site 573235002797 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 573235002798 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 573235002799 dimer interface [polypeptide binding]; other site 573235002800 putative functional site; other site 573235002801 putative MPT binding site; other site 573235002802 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 573235002803 catalytic nucleophile [active] 573235002804 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 573235002805 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 573235002806 Walker A/P-loop; other site 573235002807 ATP binding site [chemical binding]; other site 573235002808 Q-loop/lid; other site 573235002809 ABC transporter signature motif; other site 573235002810 Walker B; other site 573235002811 D-loop; other site 573235002812 H-loop/switch region; other site 573235002813 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 573235002814 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 573235002815 Walker A/P-loop; other site 573235002816 ATP binding site [chemical binding]; other site 573235002817 Q-loop/lid; other site 573235002818 ABC transporter signature motif; other site 573235002819 Walker B; other site 573235002820 D-loop; other site 573235002821 H-loop/switch region; other site 573235002822 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 573235002823 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 573235002824 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 573235002825 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 573235002826 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573235002827 dimer interface [polypeptide binding]; other site 573235002828 conserved gate region; other site 573235002829 putative PBP binding loops; other site 573235002830 ABC-ATPase subunit interface; other site 573235002831 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 573235002832 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 573235002833 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573235002834 dimer interface [polypeptide binding]; other site 573235002835 conserved gate region; other site 573235002836 putative PBP binding loops; other site 573235002837 ABC-ATPase subunit interface; other site 573235002838 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 573235002839 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 573235002840 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573235002841 metal binding site [ion binding]; metal-binding site 573235002842 active site 573235002843 I-site; other site 573235002844 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 573235002845 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 573235002846 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573235002847 FeS/SAM binding site; other site 573235002848 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 573235002849 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 573235002850 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 573235002851 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 573235002852 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 573235002853 putative C-terminal domain interface [polypeptide binding]; other site 573235002854 putative GSH binding site (G-site) [chemical binding]; other site 573235002855 putative dimer interface [polypeptide binding]; other site 573235002856 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 573235002857 N-terminal domain interface [polypeptide binding]; other site 573235002858 dimer interface [polypeptide binding]; other site 573235002859 substrate binding pocket (H-site) [chemical binding]; other site 573235002860 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 573235002861 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 573235002862 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 573235002863 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 573235002864 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 573235002865 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 573235002866 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 573235002867 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 573235002868 active site 573235002869 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 573235002870 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235002871 putative substrate translocation pore; other site 573235002872 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 573235002873 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573235002874 active site 573235002875 motif I; other site 573235002876 motif II; other site 573235002877 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573235002878 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 573235002879 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235002880 putative substrate translocation pore; other site 573235002881 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573235002882 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 573235002883 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573235002884 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 573235002885 putative transporter; Provisional; Region: PRK04972 573235002886 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 573235002887 TrkA-C domain; Region: TrkA_C; pfam02080 573235002888 TrkA-C domain; Region: TrkA_C; pfam02080 573235002889 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 573235002890 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 573235002891 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 573235002892 GSH binding site [chemical binding]; other site 573235002893 catalytic residues [active] 573235002894 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 573235002895 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 573235002896 dimer interface [polypeptide binding]; other site 573235002897 FMN binding site [chemical binding]; other site 573235002898 NADPH bind site [chemical binding]; other site 573235002899 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 573235002900 RimK-like ATP-grasp domain; Region: RimK; pfam08443 573235002901 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 573235002902 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 573235002903 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 573235002904 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 573235002905 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573235002906 Walker A/P-loop; other site 573235002907 ATP binding site [chemical binding]; other site 573235002908 Q-loop/lid; other site 573235002909 ABC transporter signature motif; other site 573235002910 Walker B; other site 573235002911 D-loop; other site 573235002912 H-loop/switch region; other site 573235002913 TOBE domain; Region: TOBE_2; pfam08402 573235002914 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 573235002915 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573235002916 dimer interface [polypeptide binding]; other site 573235002917 conserved gate region; other site 573235002918 putative PBP binding loops; other site 573235002919 ABC-ATPase subunit interface; other site 573235002920 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 573235002921 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573235002922 dimer interface [polypeptide binding]; other site 573235002923 conserved gate region; other site 573235002924 putative PBP binding loops; other site 573235002925 ABC-ATPase subunit interface; other site 573235002926 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 573235002927 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 573235002928 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573235002929 S-adenosylmethionine binding site [chemical binding]; other site 573235002930 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 573235002931 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 573235002932 substrate binding pocket [chemical binding]; other site 573235002933 membrane-bound complex binding site; other site 573235002934 hinge residues; other site 573235002935 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573235002936 dimer interface [polypeptide binding]; other site 573235002937 conserved gate region; other site 573235002938 putative PBP binding loops; other site 573235002939 ABC-ATPase subunit interface; other site 573235002940 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 573235002941 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573235002942 dimer interface [polypeptide binding]; other site 573235002943 conserved gate region; other site 573235002944 putative PBP binding loops; other site 573235002945 ABC-ATPase subunit interface; other site 573235002946 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 573235002947 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 573235002948 substrate binding pocket [chemical binding]; other site 573235002949 membrane-bound complex binding site; other site 573235002950 hinge residues; other site 573235002951 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 573235002952 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573235002953 Walker A/P-loop; other site 573235002954 ATP binding site [chemical binding]; other site 573235002955 Q-loop/lid; other site 573235002956 ABC transporter signature motif; other site 573235002957 Walker B; other site 573235002958 D-loop; other site 573235002959 H-loop/switch region; other site 573235002960 putative lipoprotein; Provisional; Region: PRK10533 573235002961 hypothetical protein; Provisional; Region: PRK02877 573235002962 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 573235002963 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 573235002964 amidase catalytic site [active] 573235002965 Zn binding residues [ion binding]; other site 573235002966 substrate binding site [chemical binding]; other site 573235002967 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 573235002968 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573235002969 NAD(P) binding site [chemical binding]; other site 573235002970 active site 573235002971 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 573235002972 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 573235002973 putative NAD(P) binding site [chemical binding]; other site 573235002974 putative active site [active] 573235002975 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 573235002976 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 573235002977 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 573235002978 tetramer interface [polypeptide binding]; other site 573235002979 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573235002980 catalytic residue [active] 573235002981 pyruvate dehydrogenase; Provisional; Region: PRK09124 573235002982 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 573235002983 PYR/PP interface [polypeptide binding]; other site 573235002984 dimer interface [polypeptide binding]; other site 573235002985 tetramer interface [polypeptide binding]; other site 573235002986 TPP binding site [chemical binding]; other site 573235002987 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 573235002988 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 573235002989 TPP-binding site [chemical binding]; other site 573235002990 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 573235002991 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 573235002992 FAD binding pocket [chemical binding]; other site 573235002993 FAD binding motif [chemical binding]; other site 573235002994 phosphate binding motif [ion binding]; other site 573235002995 beta-alpha-beta structure motif; other site 573235002996 NAD binding pocket [chemical binding]; other site 573235002997 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 573235002998 catalytic loop [active] 573235002999 iron binding site [ion binding]; other site 573235003000 hybrid cluster protein; Provisional; Region: PRK05290 573235003001 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 573235003002 ACS interaction site; other site 573235003003 CODH interaction site; other site 573235003004 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 573235003005 hybrid metal cluster; other site 573235003006 Predicted membrane protein [Function unknown]; Region: COG2431 573235003007 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 573235003008 amphipathic channel; other site 573235003009 Asn-Pro-Ala signature motifs; other site 573235003010 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 573235003011 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 573235003012 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 573235003013 putative active site [active] 573235003014 putative metal-binding site [ion binding]; other site 573235003015 Protein of unknown function (DUF535); Region: DUF535; pfam04393 573235003016 macrolide transporter subunit MacA; Provisional; Region: PRK11578 573235003017 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 573235003018 HlyD family secretion protein; Region: HlyD_3; pfam13437 573235003019 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 573235003020 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 573235003021 Walker A/P-loop; other site 573235003022 ATP binding site [chemical binding]; other site 573235003023 Q-loop/lid; other site 573235003024 ABC transporter signature motif; other site 573235003025 Walker B; other site 573235003026 D-loop; other site 573235003027 H-loop/switch region; other site 573235003028 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 573235003029 FtsX-like permease family; Region: FtsX; pfam02687 573235003030 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 573235003031 DNA-binding site [nucleotide binding]; DNA binding site 573235003032 RNA-binding motif; other site 573235003033 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 573235003034 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 573235003035 Clp amino terminal domain; Region: Clp_N; pfam02861 573235003036 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573235003037 Walker A motif; other site 573235003038 ATP binding site [chemical binding]; other site 573235003039 Walker B motif; other site 573235003040 arginine finger; other site 573235003041 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573235003042 Walker A motif; other site 573235003043 ATP binding site [chemical binding]; other site 573235003044 Walker B motif; other site 573235003045 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 573235003046 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 573235003047 rRNA binding site [nucleotide binding]; other site 573235003048 predicted 30S ribosome binding site; other site 573235003049 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 573235003050 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 573235003051 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573235003052 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 573235003053 Walker A/P-loop; other site 573235003054 ATP binding site [chemical binding]; other site 573235003055 Q-loop/lid; other site 573235003056 ABC transporter signature motif; other site 573235003057 Walker B; other site 573235003058 D-loop; other site 573235003059 H-loop/switch region; other site 573235003060 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 573235003061 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573235003062 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573235003063 Walker A/P-loop; other site 573235003064 ATP binding site [chemical binding]; other site 573235003065 Q-loop/lid; other site 573235003066 ABC transporter signature motif; other site 573235003067 Walker B; other site 573235003068 D-loop; other site 573235003069 H-loop/switch region; other site 573235003070 thioredoxin reductase; Provisional; Region: PRK10262 573235003071 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 573235003072 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 573235003073 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 573235003074 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573235003075 putative DNA binding site [nucleotide binding]; other site 573235003076 putative Zn2+ binding site [ion binding]; other site 573235003077 AsnC family; Region: AsnC_trans_reg; pfam01037 573235003078 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 573235003079 DNA translocase FtsK; Provisional; Region: PRK10263 573235003080 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 573235003081 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 573235003082 periplasmic chaperone LolA; Region: lolA; TIGR00547 573235003083 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 573235003084 recombination factor protein RarA; Reviewed; Region: PRK13342 573235003085 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573235003086 Walker A motif; other site 573235003087 ATP binding site [chemical binding]; other site 573235003088 Walker B motif; other site 573235003089 arginine finger; other site 573235003090 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 573235003091 seryl-tRNA synthetase; Provisional; Region: PRK05431 573235003092 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 573235003093 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 573235003094 dimer interface [polypeptide binding]; other site 573235003095 active site 573235003096 motif 1; other site 573235003097 motif 2; other site 573235003098 motif 3; other site 573235003099 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 573235003100 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 573235003101 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 573235003102 putative [Fe4-S4] binding site [ion binding]; other site 573235003103 putative molybdopterin cofactor binding site [chemical binding]; other site 573235003104 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 573235003105 putative molybdopterin cofactor binding site; other site 573235003106 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 573235003107 4Fe-4S binding domain; Region: Fer4; pfam00037 573235003108 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 573235003109 Isochorismatase family; Region: Isochorismatase; pfam00857 573235003110 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 573235003111 catalytic triad [active] 573235003112 dimer interface [polypeptide binding]; other site 573235003113 conserved cis-peptide bond; other site 573235003114 putative MFS family transporter protein; Provisional; Region: PRK03633 573235003115 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235003116 putative substrate translocation pore; other site 573235003117 Amino acid permease; Region: AA_permease_2; pfam13520 573235003118 Transcriptional regulator [Transcription]; Region: LysR; COG0583 573235003119 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573235003120 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 573235003121 putative effector binding pocket; other site 573235003122 putative dimerization interface [polypeptide binding]; other site 573235003123 hypothetical protein; Provisional; Region: PRK09739 573235003124 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 573235003125 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 573235003126 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573235003127 FeS/SAM binding site; other site 573235003128 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 573235003129 Pyruvate formate lyase 1; Region: PFL1; cd01678 573235003130 coenzyme A binding site [chemical binding]; other site 573235003131 active site 573235003132 catalytic residues [active] 573235003133 glycine loop; other site 573235003134 formate transporter; Provisional; Region: PRK10805 573235003135 uncharacterized domain; Region: TIGR00702 573235003136 YcaO-like family; Region: YcaO; pfam02624 573235003137 Predicted membrane protein [Function unknown]; Region: COG2323 573235003138 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 573235003139 homodimer interface [polypeptide binding]; other site 573235003140 substrate-cofactor binding pocket; other site 573235003141 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573235003142 catalytic residue [active] 573235003143 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 573235003144 Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554 573235003145 hinge; other site 573235003146 active site 573235003147 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 573235003148 cytidylate kinase; Provisional; Region: cmk; PRK00023 573235003149 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 573235003150 CMP-binding site; other site 573235003151 The sites determining sugar specificity; other site 573235003152 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 573235003153 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 573235003154 RNA binding site [nucleotide binding]; other site 573235003155 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 573235003156 RNA binding site [nucleotide binding]; other site 573235003157 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 573235003158 RNA binding site [nucleotide binding]; other site 573235003159 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 573235003160 RNA binding site [nucleotide binding]; other site 573235003161 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 573235003162 RNA binding site [nucleotide binding]; other site 573235003163 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 573235003164 IHF dimer interface [polypeptide binding]; other site 573235003165 IHF - DNA interface [nucleotide binding]; other site 573235003166 ComEC family competence protein; Provisional; Region: PRK11539 573235003167 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 573235003168 ComEC/Rec2-related protein; Region: ComEC_N-term; TIGR00360 573235003169 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 573235003170 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 573235003171 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573235003172 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 573235003173 Walker A/P-loop; other site 573235003174 ATP binding site [chemical binding]; other site 573235003175 Q-loop/lid; other site 573235003176 ABC transporter signature motif; other site 573235003177 Walker B; other site 573235003178 D-loop; other site 573235003179 H-loop/switch region; other site 573235003180 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 573235003181 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 573235003182 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 573235003183 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 573235003184 hypothetical protein; Provisional; Region: PRK11827 573235003185 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 573235003186 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 573235003187 Ligand binding site; other site 573235003188 oligomer interface; other site 573235003189 hypothetical protein; Provisional; Region: PRK10593 573235003190 Uncharacterized conserved protein [Function unknown]; Region: COG1434 573235003191 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 573235003192 putative active site [active] 573235003193 Methyltransferase domain; Region: Methyltransf_31; pfam13847 573235003194 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573235003195 S-adenosylmethionine binding site [chemical binding]; other site 573235003196 condesin subunit F; Provisional; Region: PRK05260 573235003197 condesin subunit E; Provisional; Region: PRK05256 573235003198 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 573235003199 MukB N-terminal; Region: MukB; pfam04310 573235003200 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 573235003201 murein L,D-transpeptidase; Provisional; Region: PRK10594 573235003202 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 573235003203 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 573235003204 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 573235003205 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 573235003206 Peptidase M15; Region: Peptidase_M15_3; cl01194 573235003207 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 573235003208 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 573235003209 Transposase; Region: DEDD_Tnp_IS110; pfam01548 573235003210 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 573235003211 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 573235003212 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573235003213 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573235003214 homodimer interface [polypeptide binding]; other site 573235003215 catalytic residue [active] 573235003216 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 573235003217 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 573235003218 trimer interface [polypeptide binding]; other site 573235003219 eyelet of channel; other site 573235003220 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 573235003221 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 573235003222 putative dimer interface [polypeptide binding]; other site 573235003223 putative anticodon binding site; other site 573235003224 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 573235003225 homodimer interface [polypeptide binding]; other site 573235003226 motif 1; other site 573235003227 motif 2; other site 573235003228 active site 573235003229 motif 3; other site 573235003230 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 573235003231 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 573235003232 active site 573235003233 aminopeptidase N; Provisional; Region: pepN; PRK14015 573235003234 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 573235003235 active site 573235003236 Zn binding site [ion binding]; other site 573235003237 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 573235003238 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 573235003239 Walker A/P-loop; other site 573235003240 ATP binding site [chemical binding]; other site 573235003241 Q-loop/lid; other site 573235003242 ABC transporter signature motif; other site 573235003243 Walker B; other site 573235003244 D-loop; other site 573235003245 H-loop/switch region; other site 573235003246 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 573235003247 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573235003248 dimer interface [polypeptide binding]; other site 573235003249 conserved gate region; other site 573235003250 putative PBP binding loops; other site 573235003251 ABC-ATPase subunit interface; other site 573235003252 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 573235003253 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 573235003254 active site 573235003255 dimer interface [polypeptide binding]; other site 573235003256 non-prolyl cis peptide bond; other site 573235003257 insertion regions; other site 573235003258 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 573235003259 substrate binding pocket [chemical binding]; other site 573235003260 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 573235003261 membrane-bound complex binding site; other site 573235003262 hinge residues; other site 573235003263 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 573235003264 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 573235003265 Fimbrial protein; Region: Fimbrial; cl01416 573235003266 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 573235003267 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 573235003268 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 573235003269 outer membrane usher protein; Provisional; Region: PRK15193 573235003270 PapC N-terminal domain; Region: PapC_N; pfam13954 573235003271 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 573235003272 PapC C-terminal domain; Region: PapC_C; pfam13953 573235003273 Fimbrial protein; Region: Fimbrial; cl01416 573235003274 Fimbrial protein; Region: Fimbrial; cl01416 573235003275 Fimbrial protein; Region: Fimbrial; cl01416 573235003276 putativi pili assembly chaperone; Provisional; Region: PRK11385 573235003277 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 573235003278 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 573235003279 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 573235003280 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 573235003281 quinone interaction residues [chemical binding]; other site 573235003282 active site 573235003283 catalytic residues [active] 573235003284 FMN binding site [chemical binding]; other site 573235003285 substrate binding site [chemical binding]; other site 573235003286 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 573235003287 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 573235003288 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 573235003289 MOSC domain; Region: MOSC; pfam03473 573235003290 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 573235003291 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 573235003292 catalytic loop [active] 573235003293 iron binding site [ion binding]; other site 573235003294 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 573235003295 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 573235003296 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 573235003297 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573235003298 S-adenosylmethionine binding site [chemical binding]; other site 573235003299 ABC transporter ATPase component; Reviewed; Region: PRK11147 573235003300 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573235003301 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573235003302 Walker A/P-loop; other site 573235003303 Walker A/P-loop; other site 573235003304 ATP binding site [chemical binding]; other site 573235003305 ATP binding site [chemical binding]; other site 573235003306 Q-loop/lid; other site 573235003307 Q-loop/lid; other site 573235003308 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 573235003309 ABC transporter signature motif; other site 573235003310 Walker B; other site 573235003311 D-loop; other site 573235003312 ABC transporter; Region: ABC_tran_2; pfam12848 573235003313 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 573235003314 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 573235003315 Paraquat-inducible protein A; Region: PqiA; pfam04403 573235003316 Paraquat-inducible protein A; Region: PqiA; pfam04403 573235003317 paraquat-inducible protein B; Provisional; Region: PRK10807 573235003318 mce related protein; Region: MCE; pfam02470 573235003319 mce related protein; Region: MCE; pfam02470 573235003320 mce related protein; Region: MCE; pfam02470 573235003321 DASH complex subunit Duo1; Region: DASH_Duo1; pfam08651 573235003322 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 573235003323 Protein of unknown function (DUF330); Region: DUF330; pfam03886 573235003324 ribosome modulation factor; Provisional; Region: PRK14563 573235003325 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 573235003326 active site 1 [active] 573235003327 dimer interface [polypeptide binding]; other site 573235003328 active site 2 [active] 573235003329 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 573235003330 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 573235003331 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 573235003332 outer membrane protein A; Reviewed; Region: PRK10808 573235003333 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 573235003334 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 573235003335 ligand binding site [chemical binding]; other site 573235003336 cell division inhibitor SulA; Region: sula; TIGR00623 573235003337 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 573235003338 TfoX C-terminal domain; Region: TfoX_C; pfam04994 573235003339 TIGR01666 family membrane protein; Region: YCCS 573235003340 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 573235003341 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 573235003342 Predicted membrane protein [Function unknown]; Region: COG3304 573235003343 Domain of unknown function (DUF307); Region: DUF307; pfam03733 573235003344 Domain of unknown function (DUF307); Region: DUF307; pfam03733 573235003345 DNA helicase IV; Provisional; Region: helD; PRK11054 573235003346 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 573235003347 Part of AAA domain; Region: AAA_19; pfam13245 573235003348 Family description; Region: UvrD_C_2; pfam13538 573235003349 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 573235003350 active site 573235003351 dimer interfaces [polypeptide binding]; other site 573235003352 catalytic residues [active] 573235003353 hypothetical protein; Provisional; Region: PRK03641 573235003354 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110 573235003355 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 573235003356 heat shock protein HspQ; Provisional; Region: PRK14129 573235003357 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 573235003358 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 573235003359 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 573235003360 putative RNA binding site [nucleotide binding]; other site 573235003361 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573235003362 S-adenosylmethionine binding site [chemical binding]; other site 573235003363 Acylphosphatase; Region: Acylphosphatase; cl00551 573235003364 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 573235003365 sulfur transfer protein TusE; Provisional; Region: PRK11508 573235003366 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 573235003367 YccA-like proteins; Region: YccA_like; cd10433 573235003368 Prophage ECO26_P03, lambda-like phage 573235003369 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 573235003370 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 573235003371 dimer interface [polypeptide binding]; other site 573235003372 active site 573235003373 Int/Topo IB signature motif; other site 573235003374 Domain of unknown function (DUF4224); Region: DUF4224; pfam13986 573235003375 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 573235003376 active site 573235003377 catalytic site [active] 573235003378 substrate binding site [chemical binding]; other site 573235003379 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 573235003380 DicB protein; Region: DicB; pfam05358 573235003381 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 573235003382 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 573235003383 transcriptional repressor DicA; Reviewed; Region: PRK09706 573235003384 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573235003385 non-specific DNA binding site [nucleotide binding]; other site 573235003386 salt bridge; other site 573235003387 sequence-specific DNA binding site [nucleotide binding]; other site 573235003388 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 573235003389 primosomal protein DnaI; Provisional; Region: PRK02854 573235003390 putative replication protein; Provisional; Region: PRK12377 573235003391 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573235003392 Walker A motif; other site 573235003393 ATP binding site [chemical binding]; other site 573235003394 Walker B motif; other site 573235003395 arginine finger; other site 573235003396 Protein of unknown function (DUF1627); Region: DUF1627; pfam07789 573235003397 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 573235003398 putative transposase OrfB; Reviewed; Region: PHA02517 573235003399 HTH-like domain; Region: HTH_21; pfam13276 573235003400 Integrase core domain; Region: rve; pfam00665 573235003401 Integrase core domain; Region: rve_3; pfam13683 573235003402 Transposase; Region: HTH_Tnp_1; cl17663 573235003403 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 573235003404 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 573235003405 Hok/gef family; Region: HOK_GEF; pfam01848 573235003406 Protein of unknown function (DUF968); Region: DUF968; pfam06147 573235003407 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 573235003408 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 573235003409 CAAX protease self-immunity; Region: Abi; pfam02517 573235003410 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 573235003411 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573235003412 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 573235003413 Domain of unknown function (DUF303); Region: DUF303; pfam03629 573235003414 Lysis protein S; Region: Lysis_S; pfam04971 573235003415 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 573235003416 catalytic residues [active] 573235003417 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 573235003418 Lipoprotein Rz1 precursor; Region: Rz1; pfam06085 573235003419 PerC transcriptional activator; Region: PerC; pfam06069 573235003420 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 573235003421 Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471 573235003422 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 573235003423 gpW; Region: gpW; pfam02831 573235003424 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 573235003425 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 573235003426 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 573235003427 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 573235003428 tandem repeat interface [polypeptide binding]; other site 573235003429 oligomer interface [polypeptide binding]; other site 573235003430 active site residues [active] 573235003431 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 573235003432 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 573235003433 DNA packaging protein FI; Region: Packaging_FI; pfam14000 573235003434 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 573235003435 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 573235003436 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 573235003437 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 573235003438 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 573235003439 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894 573235003440 Minor tail protein T; Region: Phage_tail_T; cl05636 573235003441 Phage-related minor tail protein [Function unknown]; Region: COG5281 573235003442 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 573235003443 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 573235003444 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 573235003445 Phage-related protein [Function unknown]; Region: COG4718 573235003446 Phage-related protein [Function unknown]; Region: gp18; COG4672 573235003447 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 573235003448 MPN+ (JAMM) motif; other site 573235003449 Zinc-binding site [ion binding]; other site 573235003450 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 573235003451 NlpC/P60 family; Region: NLPC_P60; cl17555 573235003452 Phage-related protein, tail component [Function unknown]; Region: COG4723 573235003453 Phage-related protein, tail component [Function unknown]; Region: COG4733 573235003454 Putative phage tail protein; Region: Phage-tail_3; pfam13550 573235003455 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 573235003456 Interdomain contacts; other site 573235003457 Cytokine receptor motif; other site 573235003458 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 573235003459 Fibronectin type III protein; Region: DUF3672; pfam12421 573235003460 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 573235003461 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 573235003462 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 573235003463 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 573235003464 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 573235003465 EspF protein repeat; Region: EspF; pfam04806 573235003466 EspF protein repeat; Region: EspF; pfam04806 573235003467 EspF protein repeat; Region: EspF; pfam04806 573235003468 EspF protein repeat; Region: EspF; pfam04806 573235003469 Prophage ECO26_P03; T3SS effector EspV 573235003470 Prophage ECO26_P04, lambda-like phage 573235003471 Prophage ECO26_P04; predicted integrase, C-terminal part 573235003472 Prophage ECO26_P04; predicted integrase, N-terminal part 573235003473 Domain of unknown function (DUF4224); Region: DUF4224; pfam13986 573235003474 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 573235003475 active site 573235003476 catalytic site [active] 573235003477 substrate binding site [chemical binding]; other site 573235003478 Prophage ECO26_P04; conserved predicted protein, C-terminal part 573235003479 DicB protein; Region: DicB; pfam05358 573235003480 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 573235003481 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573235003482 non-specific DNA binding site [nucleotide binding]; other site 573235003483 salt bridge; other site 573235003484 sequence-specific DNA binding site [nucleotide binding]; other site 573235003485 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573235003486 transcriptional repressor DicA; Reviewed; Region: PRK09706 573235003487 non-specific DNA binding site [nucleotide binding]; other site 573235003488 salt bridge; other site 573235003489 sequence-specific DNA binding site [nucleotide binding]; other site 573235003490 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573235003491 sequence-specific DNA binding site [nucleotide binding]; other site 573235003492 salt bridge; other site 573235003493 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 573235003494 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3756 573235003495 Pyocin large subunit [General function prediction only]; Region: COG5529 573235003496 primosomal protein DnaI; Provisional; Region: PRK02854 573235003497 Protein of unknown function (DUF1627); Region: DUF1627; pfam07789 573235003498 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 573235003499 Domain of unknown function (DUF4406); Region: DUF4406; pfam14359 573235003500 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 573235003501 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 573235003502 Protein of unknown function (DUF4014); Region: DUF4014; pfam13198 573235003503 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 573235003504 active site 573235003505 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 573235003506 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 573235003507 Protein of unknown function (DUF968); Region: DUF968; pfam06147 573235003508 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 573235003509 Protein of unknown function (DUF1133); Region: DUF1133; pfam06576 573235003510 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 573235003511 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573235003512 tellurite resistance protein terB; Region: terB; cd07176 573235003513 putative metal binding site [ion binding]; other site 573235003514 Protein of unknown function (DUF3927); Region: DUF3927; pfam13064 573235003515 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 573235003516 Domain of unknown function (DUF303); Region: DUF303; pfam03629 573235003517 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 573235003518 Protein of unknown function (DUF826); Region: DUF826; pfam05696 573235003519 Lysis protein S; Region: Lysis_S; pfam04971 573235003520 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 573235003521 catalytic residues [active] 573235003522 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 573235003523 ORF11CD3 domain; Region: ORF11CD3; pfam10549 573235003524 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 573235003525 Lipoprotein Rz1 precursor; Region: Rz1; pfam06085 573235003526 PerC transcriptional activator; Region: PerC; pfam06069 573235003527 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 573235003528 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 573235003529 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 573235003530 active site 573235003531 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 573235003532 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 573235003533 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 573235003534 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 573235003535 Phage capsid family; Region: Phage_capsid; pfam05065 573235003536 Phage-related protein [Function unknown]; Region: COG4695 573235003537 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 573235003538 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 573235003539 Bacteriophage head-tail adaptor [General function prediction only]; Region: COG5614 573235003540 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 573235003541 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 573235003542 Immunoglobulin I-set domain; Region: I-set; pfam07679 573235003543 Immunoglobulin domain; Region: Ig_2; pfam13895 573235003544 Phage tail assembly chaperone; Region: Phage_TAC; pfam06222 573235003545 Protein of unknown function (DUF4035); Region: DUF4035; pfam13227 573235003546 Phage-related minor tail protein [Function unknown]; Region: COG5281 573235003547 tape measure domain; Region: tape_meas_nterm; TIGR02675 573235003548 Tail length tape measure protein; Region: Phage_HK97_TLTM; pfam06120 573235003549 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 573235003550 Phage-related protein [Function unknown]; Region: COG4718 573235003551 Phage-related protein [Function unknown]; Region: gp18; COG4672 573235003552 Arc-like DNA binding domain; Region: Arc; pfam03869 573235003553 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 573235003554 Phage anti-repressor protein [Transcription]; Region: COG3561 573235003555 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 573235003556 MPN+ (JAMM) motif; other site 573235003557 Zinc-binding site [ion binding]; other site 573235003558 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 573235003559 NlpC/P60 family; Region: NLPC_P60; cl17555 573235003560 Phage-related protein, tail component [Function unknown]; Region: COG4723 573235003561 Phage-related protein, tail component [Function unknown]; Region: COG4733 573235003562 Putative phage tail protein; Region: Phage-tail_3; pfam13550 573235003563 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 573235003564 Interdomain contacts; other site 573235003565 Cytokine receptor motif; other site 573235003566 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 573235003567 Fibronectin type III protein; Region: DUF3672; pfam12421 573235003568 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 573235003569 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 573235003570 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 573235003571 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 573235003572 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 573235003573 AntA/AntB antirepressor; Region: AntA; pfam08346 573235003574 General stress protein [General function prediction only]; Region: GsiB; COG3729 573235003575 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 573235003576 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 573235003577 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 573235003578 putative FMN binding site [chemical binding]; other site 573235003579 pyrimidine utilization protein D; Region: RutD; TIGR03611 573235003580 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 573235003581 homotrimer interaction site [polypeptide binding]; other site 573235003582 putative active site [active] 573235003583 Isochorismatase family; Region: Isochorismatase; pfam00857 573235003584 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 573235003585 catalytic triad [active] 573235003586 conserved cis-peptide bond; other site 573235003587 pyrimidine utilization protein A; Region: RutA; TIGR03612 573235003588 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 573235003589 active site 573235003590 dimer interface [polypeptide binding]; other site 573235003591 non-prolyl cis peptide bond; other site 573235003592 insertion regions; other site 573235003593 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 573235003594 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 573235003595 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573235003596 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 573235003597 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 573235003598 Predicted transcriptional regulator [Transcription]; Region: COG3905 573235003599 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 573235003600 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 573235003601 Glutamate binding site [chemical binding]; other site 573235003602 NAD binding site [chemical binding]; other site 573235003603 catalytic residues [active] 573235003604 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 573235003605 Na binding site [ion binding]; other site 573235003606 FTR1 family protein; Region: TIGR00145 573235003607 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 573235003608 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 573235003609 Imelysin; Region: Peptidase_M75; pfam09375 573235003610 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 573235003611 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 573235003612 conserved predicted protein with nucleoside triphosphate hydrolase domain C-terminal part 573235003613 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 573235003614 Integrative element ECO26_IE02 573235003615 integrase; Provisional; Region: PRK09692 573235003616 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 573235003617 active site 573235003618 Int/Topo IB signature motif; other site 573235003619 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 573235003620 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 573235003621 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 573235003622 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 573235003623 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 573235003624 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4951 573235003625 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 573235003626 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573235003627 ATP binding site [chemical binding]; other site 573235003628 putative Mg++ binding site [ion binding]; other site 573235003629 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573235003630 nucleotide binding region [chemical binding]; other site 573235003631 ATP-binding site [chemical binding]; other site 573235003632 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 573235003633 homodimer interface [polypeptide binding]; other site 573235003634 putative GKAP docking site [polypeptide binding]; other site 573235003635 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 573235003636 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573235003637 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 573235003638 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 573235003639 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 573235003640 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573235003641 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 573235003642 Transposase; Region: HTH_Tnp_1; pfam01527 573235003643 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 573235003644 Integrative element ECO26_IE02; predicted transposase of insertion sequence IS30, N-terminal fragment 573235003645 putative transposase OrfB; Reviewed; Region: PHA02517 573235003646 Integrase core domain; Region: rve; pfam00665 573235003647 Integrase core domain; Region: rve_3; pfam13683 573235003648 Integrative element ECO26_IE02; complement resistance protein, C-terminal part 573235003649 Protein of unknown function (DUF1603); Region: DUF1603; pfam07674 573235003650 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 573235003651 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 573235003652 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 573235003653 Sulfatase; Region: Sulfatase; pfam00884 573235003654 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 573235003655 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 573235003656 alpha-gamma subunit interface [polypeptide binding]; other site 573235003657 beta-gamma subunit interface [polypeptide binding]; other site 573235003658 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 573235003659 gamma-beta subunit interface [polypeptide binding]; other site 573235003660 alpha-beta subunit interface [polypeptide binding]; other site 573235003661 urease subunit alpha; Reviewed; Region: ureC; PRK13207 573235003662 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 573235003663 subunit interactions [polypeptide binding]; other site 573235003664 active site 573235003665 flap region; other site 573235003666 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 573235003667 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 573235003668 dimer interface [polypeptide binding]; other site 573235003669 catalytic residues [active] 573235003670 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 573235003671 UreF; Region: UreF; pfam01730 573235003672 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 573235003673 Integrative element ECO26_IE02; secreted autotransporter serine protease, C-terminal fragment 573235003674 Integrative element ECO26_IE02; predicted transposase OrfA protein of insertion sequence IS600, N-terminal fragment 573235003675 Integrative element ECO26_IE02; predicted protein, N-terminal part 573235003676 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 573235003677 Integrative element ECO26_IE02; conserved predicted protein, C-terminal fragment 573235003678 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 573235003679 Transposase; Region: HTH_Tnp_1; pfam01527 573235003680 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573235003681 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 573235003682 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 573235003683 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573235003684 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 573235003685 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 573235003686 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 573235003687 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 573235003688 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573235003689 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 573235003690 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 573235003691 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 573235003692 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573235003693 Predicted transcriptional regulator [Transcription]; Region: COG2378 573235003694 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 573235003695 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 573235003696 Protein of unknown function (DUF2983); Region: DUF2983; pfam11202 573235003697 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 573235003698 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 573235003699 active site 573235003700 Protein of unknown function (DUF3706); Region: DUF3706; pfam12500 573235003701 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 573235003702 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 573235003703 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 573235003704 putative metal binding site [ion binding]; other site 573235003705 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 573235003706 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 573235003707 putative metal binding site [ion binding]; other site 573235003708 Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110 573235003709 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 573235003710 putative metal binding site [ion binding]; other site 573235003711 tellurite resistance protein terB; Region: terB; cd07176 573235003712 putative metal binding site [ion binding]; other site 573235003713 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 573235003714 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 573235003715 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 573235003716 putative metal binding site [ion binding]; other site 573235003717 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 573235003718 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 573235003719 putative metal binding site [ion binding]; other site 573235003720 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 573235003721 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 573235003722 putative metal binding site [ion binding]; other site 573235003723 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 573235003724 bifunctional enterobactin receptor/adhesin protein; Provisional; Region: PRK13486 573235003725 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 573235003726 N-terminal plug; other site 573235003727 ligand-binding site [chemical binding]; other site 573235003728 bifunctional enterobactin receptor/adhesin protein; Provisional; Region: PRK13486 573235003729 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 573235003730 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 573235003731 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 573235003732 homodimer interface [polypeptide binding]; other site 573235003733 TDP-binding site; other site 573235003734 Integrative element ECO26_IE02; predicted ferric enterochelin esterase, C-terminal fragment 573235003735 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 573235003736 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 573235003737 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 573235003738 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 573235003739 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 573235003740 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 573235003741 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 573235003742 adhesin HecA family 20-residue repeat (two copies); Region: fil_hemag_20aa; TIGR01731 573235003743 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 573235003744 Part of AAA domain; Region: AAA_19; pfam13245 573235003745 AAA domain; Region: AAA_12; pfam13087 573235003746 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 573235003747 Integrative element ECO26_IE02; conserved predicted protein, N-terminal part 573235003748 Integrative element ECO26_IE02; conserved predicted protein, C-terminal part 573235003749 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 573235003750 ParB-like nuclease domain; Region: ParB; smart00470 573235003751 PerC transcriptional activator; Region: PerC; pfam06069 573235003752 putative transposase OrfB; Reviewed; Region: PHA02517 573235003753 HTH-like domain; Region: HTH_21; pfam13276 573235003754 Integrase core domain; Region: rve; pfam00665 573235003755 Integrase core domain; Region: rve_3; pfam13683 573235003756 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235003757 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573235003758 putative substrate translocation pore; other site 573235003759 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 573235003760 IucA / IucC family; Region: IucA_IucC; pfam04183 573235003761 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 573235003762 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 573235003763 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 573235003764 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 573235003765 IucA / IucC family; Region: IucA_IucC; pfam04183 573235003766 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 573235003767 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 573235003768 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 573235003769 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 573235003770 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 573235003771 N-terminal plug; other site 573235003772 ligand-binding site [chemical binding]; other site 573235003773 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 573235003774 Transposase; Region: HTH_Tnp_1; pfam01527 573235003775 Predicted GTPase [General function prediction only]; Region: COG3596 573235003776 YfjP GTPase; Region: YfjP; cd11383 573235003777 G1 box; other site 573235003778 GTP/Mg2+ binding site [chemical binding]; other site 573235003779 Switch I region; other site 573235003780 G2 box; other site 573235003781 Switch II region; other site 573235003782 G3 box; other site 573235003783 G4 box; other site 573235003784 G5 box; other site 573235003785 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 573235003786 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 573235003787 hypothetical protein; Provisional; Region: PRK09945 573235003788 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 573235003789 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 573235003790 Autotransporter beta-domain; Region: Autotransporter; smart00869 573235003791 hypothetical protein; Provisional; Region: PRK09866 573235003792 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 573235003793 G1 box; other site 573235003794 GTP/Mg2+ binding site [chemical binding]; other site 573235003795 G2 box; other site 573235003796 Switch I region; other site 573235003797 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 573235003798 G3 box; other site 573235003799 Switch II region; other site 573235003800 GTP/Mg2+ binding site [chemical binding]; other site 573235003801 G4 box; other site 573235003802 G5 box; other site 573235003803 YjcZ-like protein; Region: YjcZ; pfam13990 573235003804 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 573235003805 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 573235003806 nucleophile elbow; other site 573235003807 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 573235003808 Domain of unknown function (DUF932); Region: DUF932; pfam06067 573235003809 Antirestriction protein; Region: Antirestrict; pfam03230 573235003810 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 573235003811 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 573235003812 MPN+ (JAMM) motif; other site 573235003813 Zinc-binding site [ion binding]; other site 573235003814 Protein of unknown function (DUF987); Region: DUF987; pfam06174 573235003815 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 573235003816 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 573235003817 Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117 573235003818 Methyltransferase domain; Region: Methyltransf_27; pfam13708 573235003819 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 573235003820 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 573235003821 putative ligand binding site [chemical binding]; other site 573235003822 NAD binding site [chemical binding]; other site 573235003823 dimerization interface [polypeptide binding]; other site 573235003824 catalytic site [active] 573235003825 putative hydrolase; Validated; Region: PRK09248 573235003826 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 573235003827 active site 573235003828 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 573235003829 predicted inner membrane protein, C-terminal part 573235003830 curli production assembly/transport protein CsgG; Provisional; Region: PRK15184 573235003831 curli assembly protein CsgF; Provisional; Region: PRK10050 573235003832 curli assembly protein CsgE; Provisional; Region: PRK10386 573235003833 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 573235003834 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573235003835 DNA binding residues [nucleotide binding] 573235003836 dimerization interface [polypeptide binding]; other site 573235003837 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 573235003838 Curlin associated repeat; Region: Curlin_rpt; pfam07012 573235003839 Curlin associated repeat; Region: Curlin_rpt; pfam07012 573235003840 major curlin subunit; Provisional; Region: csgA; PRK10051 573235003841 Curlin associated repeat; Region: Curlin_rpt; pfam07012 573235003842 Curlin associated repeat; Region: Curlin_rpt; pfam07012 573235003843 curli assembly protein CsgC; Provisional; Region: csgC; PRK10102 573235003844 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 573235003845 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 573235003846 putative ADP-ribose binding site [chemical binding]; other site 573235003847 putative active site [active] 573235003848 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 573235003849 PLD-like domain; Region: PLDc_2; pfam13091 573235003850 putative active site [active] 573235003851 catalytic site [active] 573235003852 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 573235003853 PLD-like domain; Region: PLDc_2; pfam13091 573235003854 putative active site [active] 573235003855 catalytic site [active] 573235003856 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 573235003857 Acyltransferase family; Region: Acyl_transf_3; pfam01757 573235003858 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 573235003859 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349 573235003860 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 573235003861 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 573235003862 Ligand binding site; other site 573235003863 DXD motif; other site 573235003864 lipoprotein; Provisional; Region: PRK10175 573235003865 secY/secA suppressor protein; Provisional; Region: PRK11467 573235003866 drug efflux system protein MdtG; Provisional; Region: PRK09874 573235003867 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235003868 putative substrate translocation pore; other site 573235003869 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 573235003870 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 573235003871 putative acyl-acceptor binding pocket; other site 573235003872 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 573235003873 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 573235003874 active site residue [active] 573235003875 hypothetical protein; Provisional; Region: PRK03757 573235003876 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 573235003877 Protein of unknown function (DUF2770); Region: DUF2770; pfam10968 573235003878 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 573235003879 hydroxyglutarate oxidase; Provisional; Region: PRK11728 573235003880 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 573235003881 DNA damage-inducible protein I; Provisional; Region: PRK10597 573235003882 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 573235003883 active site 573235003884 substrate binding pocket [chemical binding]; other site 573235003885 dimer interface [polypeptide binding]; other site 573235003886 lipoprotein; Provisional; Region: PRK10598 573235003887 glutaredoxin 2; Provisional; Region: PRK10387 573235003888 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 573235003889 C-terminal domain interface [polypeptide binding]; other site 573235003890 GSH binding site (G-site) [chemical binding]; other site 573235003891 catalytic residues [active] 573235003892 putative dimer interface [polypeptide binding]; other site 573235003893 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 573235003894 N-terminal domain interface [polypeptide binding]; other site 573235003895 multidrug resistance protein MdtH; Provisional; Region: PRK11646 573235003896 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235003897 putative substrate translocation pore; other site 573235003898 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 573235003899 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 573235003900 hypothetical protein; Provisional; Region: PRK11239 573235003901 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 573235003902 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 573235003903 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 573235003904 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 573235003905 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 573235003906 MviN-like protein; Region: MVIN; pfam03023 573235003907 flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459 573235003908 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 573235003909 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 573235003910 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 573235003911 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 573235003912 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 573235003913 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 573235003914 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 573235003915 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 573235003916 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 573235003917 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 573235003918 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 573235003919 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 573235003920 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 573235003921 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 573235003922 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 573235003923 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 573235003924 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787 573235003925 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 573235003926 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 573235003927 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 573235003928 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 573235003929 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 573235003930 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 573235003931 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 573235003932 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 573235003933 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 573235003934 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 573235003935 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 573235003936 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 573235003937 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 573235003938 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 573235003939 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 573235003940 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 573235003941 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 573235003942 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 573235003943 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 573235003944 homodimer interface [polypeptide binding]; other site 573235003945 oligonucleotide binding site [chemical binding]; other site 573235003946 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 573235003947 Protein of unknown function (DUF2655); Region: DUF2655; pfam10848 573235003948 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 573235003949 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 573235003950 RNA binding surface [nucleotide binding]; other site 573235003951 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 573235003952 active site 573235003953 Maf-like protein; Region: Maf; pfam02545 573235003954 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 573235003955 active site 573235003956 dimer interface [polypeptide binding]; other site 573235003957 hypothetical protein; Provisional; Region: PRK11193 573235003958 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 573235003959 putative phosphate acyltransferase; Provisional; Region: PRK05331 573235003960 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 573235003961 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 573235003962 dimer interface [polypeptide binding]; other site 573235003963 active site 573235003964 CoA binding pocket [chemical binding]; other site 573235003965 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 573235003966 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 573235003967 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 573235003968 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 573235003969 NAD(P) binding site [chemical binding]; other site 573235003970 homotetramer interface [polypeptide binding]; other site 573235003971 homodimer interface [polypeptide binding]; other site 573235003972 active site 573235003973 acyl carrier protein; Provisional; Region: acpP; PRK00982 573235003974 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 573235003975 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 573235003976 dimer interface [polypeptide binding]; other site 573235003977 active site 573235003978 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 573235003979 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 573235003980 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573235003981 catalytic residue [active] 573235003982 conserved hypothetical protein, YceG family; Region: TIGR00247 573235003983 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 573235003984 dimerization interface [polypeptide binding]; other site 573235003985 thymidylate kinase; Validated; Region: tmk; PRK00698 573235003986 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 573235003987 TMP-binding site; other site 573235003988 ATP-binding site [chemical binding]; other site 573235003989 DNA polymerase III subunit delta'; Validated; Region: PRK07993 573235003990 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 573235003991 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 573235003992 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 573235003993 active site 573235003994 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 573235003995 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 573235003996 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 573235003997 active site turn [active] 573235003998 phosphorylation site [posttranslational modification] 573235003999 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 573235004000 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 573235004001 N-terminal plug; other site 573235004002 ligand-binding site [chemical binding]; other site 573235004003 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 573235004004 nucleotide binding site/active site [active] 573235004005 HIT family signature motif; other site 573235004006 catalytic residue [active] 573235004007 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 573235004008 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 573235004009 putative dimer interface [polypeptide binding]; other site 573235004010 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 573235004011 thiamine kinase; Region: ycfN_thiK; TIGR02721 573235004012 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 573235004013 active site 573235004014 substrate binding site [chemical binding]; other site 573235004015 ATP binding site [chemical binding]; other site 573235004016 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 573235004017 beta-hexosaminidase; Provisional; Region: PRK05337 573235004018 hypothetical protein; Provisional; Region: PRK04940 573235004019 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 573235004020 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 573235004021 hypothetical protein; Provisional; Region: PRK11280 573235004022 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573235004023 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573235004024 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 573235004025 L,D-transpeptidase; Provisional; Region: PRK10260 573235004026 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 573235004027 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 573235004028 transcription-repair coupling factor; Provisional; Region: PRK10689 573235004029 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 573235004030 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573235004031 ATP binding site [chemical binding]; other site 573235004032 putative Mg++ binding site [ion binding]; other site 573235004033 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573235004034 nucleotide binding region [chemical binding]; other site 573235004035 ATP-binding site [chemical binding]; other site 573235004036 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 573235004037 Predicted membrane protein [Function unknown]; Region: COG4763 573235004038 Acyltransferase family; Region: Acyl_transf_3; pfam01757 573235004039 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 573235004040 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 573235004041 FtsX-like permease family; Region: FtsX; pfam02687 573235004042 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 573235004043 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 573235004044 Walker A/P-loop; other site 573235004045 ATP binding site [chemical binding]; other site 573235004046 Q-loop/lid; other site 573235004047 ABC transporter signature motif; other site 573235004048 Walker B; other site 573235004049 D-loop; other site 573235004050 H-loop/switch region; other site 573235004051 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 573235004052 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 573235004053 FtsX-like permease family; Region: FtsX; pfam02687 573235004054 fructokinase; Reviewed; Region: PRK09557 573235004055 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 573235004056 nucleotide binding site [chemical binding]; other site 573235004057 NAD-dependent deacetylase; Provisional; Region: PRK00481 573235004058 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 573235004059 NAD+ binding site [chemical binding]; other site 573235004060 substrate binding site [chemical binding]; other site 573235004061 Zn binding site [ion binding]; other site 573235004062 Repair protein; Region: Repair_PSII; cl01535 573235004063 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 573235004064 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 573235004065 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 573235004066 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 573235004067 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573235004068 dimer interface [polypeptide binding]; other site 573235004069 conserved gate region; other site 573235004070 putative PBP binding loops; other site 573235004071 ABC-ATPase subunit interface; other site 573235004072 Prophage ECO26_P05, lambda-like phage 573235004073 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 573235004074 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 573235004075 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 573235004076 dimer interface [polypeptide binding]; other site 573235004077 active site 573235004078 Int/Topo IB signature motif; other site 573235004079 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 573235004080 active site 573235004081 catalytic site [active] 573235004082 substrate binding site [chemical binding]; other site 573235004083 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 573235004084 DicB protein; Region: DicB; pfam05358 573235004085 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 573235004086 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573235004087 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 573235004088 non-specific DNA binding site [nucleotide binding]; other site 573235004089 salt bridge; other site 573235004090 sequence-specific DNA binding site [nucleotide binding]; other site 573235004091 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 573235004092 Catalytic site [active] 573235004093 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 573235004094 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 573235004095 Pyocin large subunit [General function prediction only]; Region: COG5529 573235004096 primosomal protein DnaI; Provisional; Region: PRK02854 573235004097 Protein of unknown function (DUF1627); Region: DUF1627; pfam07789 573235004098 Hok/gef family; Region: HOK_GEF; pfam01848 573235004099 Protein of unknown function (DUF968); Region: DUF968; pfam06147 573235004100 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 573235004101 Protein of unknown function (DUF1133); Region: DUF1133; pfam06576 573235004102 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573235004103 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 573235004104 DNA methylase; Region: N6_N4_Mtase; pfam01555 573235004105 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 573235004106 tellurite resistance protein terB; Region: terB; cd07176 573235004107 putative metal binding site [ion binding]; other site 573235004108 Protein of unknown function (DUF3927); Region: DUF3927; pfam13064 573235004109 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 573235004110 Domain of unknown function (DUF303); Region: DUF303; pfam03629 573235004111 Lysis protein S; Region: Lysis_S; pfam04971 573235004112 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 573235004113 catalytic residues [active] 573235004114 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 573235004115 Lipoprotein Rz1 precursor; Region: Rz1; pfam06085 573235004116 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 573235004117 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 573235004118 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 573235004119 active site 573235004120 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 573235004121 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 573235004122 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 573235004123 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 573235004124 Phage capsid family; Region: Phage_capsid; pfam05065 573235004125 Phage-related protein [Function unknown]; Region: COG4695 573235004126 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 573235004127 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 573235004128 Bacteriophage head-tail adaptor [General function prediction only]; Region: COG5614 573235004129 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 573235004130 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 573235004131 Immunoglobulin I-set domain; Region: I-set; pfam07679 573235004132 Immunoglobulin domain; Region: Ig_2; pfam13895 573235004133 Phage tail assembly chaperone; Region: Phage_TAC; pfam06222 573235004134 Protein of unknown function (DUF4035); Region: DUF4035; pfam13227 573235004135 Phage-related minor tail protein [Function unknown]; Region: COG5281 573235004136 tape measure domain; Region: tape_meas_nterm; TIGR02675 573235004137 Tail length tape measure protein; Region: Phage_HK97_TLTM; pfam06120 573235004138 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 573235004139 Phage-related protein [Function unknown]; Region: COG4718 573235004140 Phage-related protein [Function unknown]; Region: gp18; COG4672 573235004141 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 573235004142 MPN+ (JAMM) motif; other site 573235004143 Zinc-binding site [ion binding]; other site 573235004144 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 573235004145 NlpC/P60 family; Region: NLPC_P60; cl17555 573235004146 Phage-related protein, tail component [Function unknown]; Region: COG4723 573235004147 Phage-related protein, tail component [Function unknown]; Region: COG4733 573235004148 Putative phage tail protein; Region: Phage-tail_3; pfam13550 573235004149 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 573235004150 Interdomain contacts; other site 573235004151 Cytokine receptor motif; other site 573235004152 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 573235004153 Fibronectin type III protein; Region: DUF3672; pfam12421 573235004154 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 573235004155 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 573235004156 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 573235004157 Transposase; Region: HTH_Tnp_1; pfam01527 573235004158 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 573235004159 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573235004160 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 573235004161 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 573235004162 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 573235004163 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573235004164 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 573235004165 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 573235004166 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 573235004167 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 573235004168 magnesiumprotoporphyrin-IX chelatase subunit H; Provisional; Region: PLN03069 573235004169 type III secretion protein GogB; Provisional; Region: PRK15386 573235004170 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 573235004171 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 573235004172 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 573235004173 hydrogenase 1 large subunit; Provisional; Region: PRK10170 573235004174 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 573235004175 hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171 573235004176 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 573235004177 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 573235004178 putative substrate-binding site; other site 573235004179 nickel binding site [ion binding]; other site 573235004180 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 573235004181 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 573235004182 cytochrome bd-II oxidase, subunit I, C-terminal part 573235004183 cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028 573235004184 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 573235004185 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 573235004186 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 573235004187 catalytic core [active] 573235004188 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 573235004189 cryptic autophosphorylating protein tyrosine kinase Etk; Provisional; Region: PRK09841 573235004190 Chain length determinant protein; Region: Wzz; pfam02706 573235004191 Chain length determinant protein; Region: Wzz; cl15801 573235004192 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 573235004193 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 573235004194 Nucleotide binding site [chemical binding]; other site 573235004195 Low molecular weight phosphatase family; Region: LMWPc; cd00115 573235004196 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 573235004197 active site 573235004198 polysaccharide export protein Wza; Provisional; Region: PRK15078 573235004199 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 573235004200 SLBB domain; Region: SLBB; pfam10531 573235004201 SLBB domain; Region: SLBB; pfam10531 573235004202 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 573235004203 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 573235004204 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 573235004205 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 573235004206 DNA-binding site [nucleotide binding]; DNA binding site 573235004207 RNA-binding motif; other site 573235004208 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 573235004209 DNA-binding site [nucleotide binding]; DNA binding site 573235004210 RNA-binding motif; other site 573235004211 cold shock gene; Provisional; Region: PRK09891 573235004212 GnsA/GnsB family; Region: GnsAB; pfam08178 573235004213 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 573235004214 4Fe-4S binding domain; Region: Fer4_5; pfam12801 573235004215 4Fe-4S binding domain; Region: Fer4_5; pfam12801 573235004216 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 573235004217 hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466 573235004218 HAMP domain; Region: HAMP; pfam00672 573235004219 dimerization interface [polypeptide binding]; other site 573235004220 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573235004221 dimer interface [polypeptide binding]; other site 573235004222 phosphorylation site [posttranslational modification] 573235004223 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573235004224 ATP binding site [chemical binding]; other site 573235004225 Mg2+ binding site [ion binding]; other site 573235004226 G-X-G motif; other site 573235004227 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573235004228 active site 573235004229 phosphorylation site [posttranslational modification] 573235004230 intermolecular recognition site; other site 573235004231 dimerization interface [polypeptide binding]; other site 573235004232 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 573235004233 putative binding surface; other site 573235004234 active site 573235004235 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 573235004236 TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306 573235004237 putative ligand binding site [chemical binding]; other site 573235004238 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 573235004239 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573235004240 active site 573235004241 phosphorylation site [posttranslational modification] 573235004242 intermolecular recognition site; other site 573235004243 dimerization interface [polypeptide binding]; other site 573235004244 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573235004245 DNA binding site [nucleotide binding] 573235004246 trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032 573235004247 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 573235004248 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 573235004249 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 573235004250 molybdopterin cofactor binding site [chemical binding]; other site 573235004251 substrate binding site [chemical binding]; other site 573235004252 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 573235004253 molybdopterin cofactor binding site; other site 573235004254 chaperone protein TorD; Validated; Region: torD; PRK04976 573235004255 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 573235004256 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 573235004257 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 573235004258 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 573235004259 HSP70 interaction site [polypeptide binding]; other site 573235004260 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 573235004261 substrate binding site [polypeptide binding]; other site 573235004262 dimer interface [polypeptide binding]; other site 573235004263 hypothetical protein; Provisional; Region: PRK09784 573235004264 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 573235004265 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 573235004266 catalytic core [active] 573235004267 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 573235004268 hypothetical protein; Provisional; Region: PRK10174 573235004269 truncated Trp repressor binding protein WrbA 573235004270 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 573235004271 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 573235004272 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 573235004273 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 573235004274 Int/Topo IB signature motif; other site 573235004275 Prophage ECO26_P06, lambda-like phage 573235004276 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 573235004277 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 573235004278 Protein of unknown function (DUF1627); Region: DUF1627; pfam07789 573235004279 Protein of unknown function (DUF1382); Region: DUF1382; pfam07131 573235004280 Protein of unknown function (DUF551); Region: DUF551; pfam04448 573235004281 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 573235004282 urea carboxylase; Region: urea_carbox; TIGR02712 573235004283 Protein of unknown function (DUF2737); Region: DUF2737; pfam10930 573235004284 Protein of unknown function (DUF2856); Region: DUF2856; pfam11043 573235004285 RNA helicase; Region: RNA_helicase; pfam00910 573235004286 AAA domain; Region: AAA_22; pfam13401 573235004287 Bacteriophage lambda Kil protein; Region: Lambda_Kil; pfam06301 573235004288 Lambda Phage CIII; Region: Lambda_CIII; pfam02061 573235004289 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 573235004290 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 573235004291 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573235004292 non-specific DNA binding site [nucleotide binding]; other site 573235004293 salt bridge; other site 573235004294 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 573235004295 sequence-specific DNA binding site [nucleotide binding]; other site 573235004296 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 573235004297 Catalytic site [active] 573235004298 Bacteriophage CII protein; Region: Phage_CII; pfam05269 573235004299 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 573235004300 Replication protein P; Region: Phage_lambda_P; pfam06992 573235004301 NinB protein; Region: NinB; pfam05772 573235004302 phage N-6-adenine-methyltransferase; Region: phage_N6A_met; TIGR01712 573235004303 NINE Protein; Region: NinE; pfam05322 573235004304 ORF6N domain; Region: ORF6N; pfam10543 573235004305 Phage anti-repressor protein [Transcription]; Region: COG3561 573235004306 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 573235004307 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 573235004308 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 573235004309 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 573235004310 Ribosome inactivating protein; Region: RIP; pfam00161 573235004311 Shiga-like toxin beta subunit; Region: SLT_beta; pfam02258 573235004312 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 573235004313 Domain of unknown function (DUF303); Region: DUF303; pfam03629 573235004314 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 573235004315 Protein of unknown function (DUF1378); Region: DUF1378; pfam07125 573235004316 Protein of unknown function (DUF826); Region: DUF826; pfam05696 573235004317 Lysis protein S; Region: Lysis_S; pfam04971 573235004318 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 573235004319 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 573235004320 catalytic residues [active] 573235004321 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 573235004322 ORF11CD3 domain; Region: ORF11CD3; pfam10549 573235004323 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 573235004324 Lipoprotein Rz1 precursor; Region: Rz1; pfam06085 573235004325 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 573235004326 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 573235004327 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 573235004328 active site 573235004329 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 573235004330 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 573235004331 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 573235004332 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 573235004333 Phage capsid family; Region: Phage_capsid; pfam05065 573235004334 Phage-related protein [Function unknown]; Region: COG4695 573235004335 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 573235004336 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 573235004337 Bacteriophage head-tail adaptor [General function prediction only]; Region: COG5614 573235004338 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 573235004339 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 573235004340 Immunoglobulin I-set domain; Region: I-set; pfam07679 573235004341 Immunoglobulin domain; Region: Ig_2; pfam13895 573235004342 Phage tail assembly chaperone; Region: Phage_TAC; pfam06222 573235004343 Protein of unknown function (DUF4035); Region: DUF4035; pfam13227 573235004344 Phage-related minor tail protein [Function unknown]; Region: COG5281 573235004345 tape measure domain; Region: tape_meas_nterm; TIGR02675 573235004346 Tail length tape measure protein; Region: Phage_HK97_TLTM; pfam06120 573235004347 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 573235004348 Phage-related protein [Function unknown]; Region: COG4718 573235004349 Phage-related protein [Function unknown]; Region: gp18; COG4672 573235004350 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 573235004351 MPN+ (JAMM) motif; other site 573235004352 Zinc-binding site [ion binding]; other site 573235004353 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 573235004354 NlpC/P60 family; Region: NLPC_P60; cl17555 573235004355 Phage-related protein, tail component [Function unknown]; Region: COG4723 573235004356 Phage-related protein, tail component [Function unknown]; Region: COG4733 573235004357 Putative phage tail protein; Region: Phage-tail_3; pfam13550 573235004358 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 573235004359 Interdomain contacts; other site 573235004360 Cytokine receptor motif; other site 573235004361 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 573235004362 Fibronectin type III protein; Region: DUF3672; pfam12421 573235004363 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 573235004364 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 573235004365 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 573235004366 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 573235004367 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 573235004368 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 573235004369 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 573235004370 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 573235004371 IpaB/EvcA family; Region: IpaB_EvcA; pfam03278 573235004372 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 573235004373 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573235004374 dimer interface [polypeptide binding]; other site 573235004375 conserved gate region; other site 573235004376 putative PBP binding loops; other site 573235004377 ABC-ATPase subunit interface; other site 573235004378 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 573235004379 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573235004380 Walker A/P-loop; other site 573235004381 ATP binding site [chemical binding]; other site 573235004382 Q-loop/lid; other site 573235004383 ABC transporter signature motif; other site 573235004384 Walker B; other site 573235004385 D-loop; other site 573235004386 H-loop/switch region; other site 573235004387 TOBE domain; Region: TOBE_2; pfam08402 573235004388 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 573235004389 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 573235004390 metal binding site [ion binding]; metal-binding site 573235004391 dimer interface [polypeptide binding]; other site 573235004392 Uncharacterized conserved protein [Function unknown]; Region: COG2850 573235004393 Cupin-like domain; Region: Cupin_8; pfam13621 573235004394 Prophage ECO26_P07, untypable 573235004395 integrase; Provisional; Region: PRK09692 573235004396 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 573235004397 active site 573235004398 Int/Topo IB signature motif; other site 573235004399 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 573235004400 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 573235004401 AAA domain; Region: AAA_25; pfam13481 573235004402 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 573235004403 Walker A motif; other site 573235004404 ATP binding site [chemical binding]; other site 573235004405 Walker B motif; other site 573235004406 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 573235004407 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 573235004408 ssDNA binding site [nucleotide binding]; other site 573235004409 dimer interface [polypeptide binding]; other site 573235004410 tetramer (dimer of dimers) interface [polypeptide binding]; other site 573235004411 PerC transcriptional activator; Region: PerC; pfam06069 573235004412 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 573235004413 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 573235004414 Phage DNA packaging protein Nu1; Region: Phage_Nu1; cl01720 573235004415 sensor protein PhoQ; Provisional; Region: PRK10815 573235004416 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 573235004417 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 573235004418 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 573235004419 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573235004420 ATP binding site [chemical binding]; other site 573235004421 Mg2+ binding site [ion binding]; other site 573235004422 G-X-G motif; other site 573235004423 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 573235004424 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573235004425 active site 573235004426 phosphorylation site [posttranslational modification] 573235004427 intermolecular recognition site; other site 573235004428 dimerization interface [polypeptide binding]; other site 573235004429 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573235004430 DNA binding site [nucleotide binding] 573235004431 adenylosuccinate lyase; Provisional; Region: PRK09285 573235004432 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 573235004433 tetramer interface [polypeptide binding]; other site 573235004434 active site 573235004435 putative lysogenization regulator; Reviewed; Region: PRK00218 573235004436 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 573235004437 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 573235004438 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 573235004439 nudix motif; other site 573235004440 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 573235004441 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 573235004442 probable active site [active] 573235004443 isocitrate dehydrogenase; Validated; Region: PRK07362 573235004444 isocitrate dehydrogenase; Reviewed; Region: PRK07006 573235004445 anti-adapter protein IraM; Provisional; Region: PRK09919 573235004446 Protein of unknown function (DUF1398); Region: DUF1398; pfam07166 573235004447 transcriptional regulator MirA; Provisional; Region: PRK15043 573235004448 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 573235004449 DNA binding residues [nucleotide binding] 573235004450 Sensors of blue-light using FAD; Region: BLUF; smart01034 573235004451 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 573235004452 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 573235004453 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 573235004454 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 573235004455 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 573235004456 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 573235004457 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 573235004458 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 573235004459 Autotransporter beta-domain; Region: Autotransporter; smart00869 573235004460 Autotransporter beta-domain; Region: Autotransporter; cl17461 573235004461 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 573235004462 cell division inhibitor MinD; Provisional; Region: PRK10818 573235004463 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 573235004464 Switch I; other site 573235004465 Switch II; other site 573235004466 septum formation inhibitor; Reviewed; Region: minC; PRK03511 573235004467 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 573235004468 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 573235004469 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 573235004470 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 573235004471 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 573235004472 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 573235004473 hypothetical protein; Provisional; Region: PRK10691 573235004474 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 573235004475 hypothetical protein; Provisional; Region: PRK05170 573235004476 hemolysin E; Provisional; Region: hlyE; PRK11376 573235004477 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 573235004478 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 573235004479 Catalytic site [active] 573235004480 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 573235004481 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 573235004482 active site 573235004483 DNA binding site [nucleotide binding] 573235004484 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 573235004485 disulfide bond formation protein B; Provisional; Region: PRK01749 573235004486 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 573235004487 transmembrane helices; other site 573235004488 fatty acid metabolism regulator; Provisional; Region: PRK04984 573235004489 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573235004490 DNA-binding site [nucleotide binding]; DNA binding site 573235004491 FadR C-terminal domain; Region: FadR_C; pfam07840 573235004492 SpoVR family protein; Provisional; Region: PRK11767 573235004493 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 573235004494 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 573235004495 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 573235004496 alanine racemase; Reviewed; Region: dadX; PRK03646 573235004497 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 573235004498 active site 573235004499 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 573235004500 substrate binding site [chemical binding]; other site 573235004501 catalytic residues [active] 573235004502 dimer interface [polypeptide binding]; other site 573235004503 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 573235004504 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 573235004505 TrkA-C domain; Region: TrkA_C; pfam02080 573235004506 Transporter associated domain; Region: CorC_HlyC; smart01091 573235004507 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 573235004508 dimer interface [polypeptide binding]; other site 573235004509 catalytic triad [active] 573235004510 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 573235004511 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 573235004512 N-acetyl-D-glucosamine binding site [chemical binding]; other site 573235004513 catalytic residue [active] 573235004514 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 573235004515 Flagellar regulator YcgR; Region: YcgR; pfam07317 573235004516 PilZ domain; Region: PilZ; pfam07238 573235004517 hypothetical protein; Provisional; Region: PRK10457 573235004518 trehalase; Provisional; Region: treA; PRK13271 573235004519 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 573235004520 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 573235004521 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3412 573235004522 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 573235004523 dimerization domain swap beta strand [polypeptide binding]; other site 573235004524 regulatory protein interface [polypeptide binding]; other site 573235004525 active site 573235004526 regulatory phosphorylation site [posttranslational modification]; other site 573235004527 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 573235004528 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 573235004529 dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005 573235004530 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 573235004531 Dak1 domain; Region: Dak1; pfam02733 573235004532 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 573235004533 PAS domain; Region: PAS; smart00091 573235004534 putative active site [active] 573235004535 heme pocket [chemical binding]; other site 573235004536 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573235004537 Walker A motif; other site 573235004538 ATP binding site [chemical binding]; other site 573235004539 Walker B motif; other site 573235004540 arginine finger; other site 573235004541 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 573235004542 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 573235004543 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 573235004544 Autotransporter beta-domain; Region: Autotransporter; pfam03797 573235004545 GTP-binding protein YchF; Reviewed; Region: PRK09601 573235004546 YchF GTPase; Region: YchF; cd01900 573235004547 G1 box; other site 573235004548 GTP/Mg2+ binding site [chemical binding]; other site 573235004549 Switch I region; other site 573235004550 G2 box; other site 573235004551 Switch II region; other site 573235004552 G3 box; other site 573235004553 G4 box; other site 573235004554 G5 box; other site 573235004555 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 573235004556 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 573235004557 putative active site [active] 573235004558 catalytic residue [active] 573235004559 hypothetical protein; Provisional; Region: PRK10692 573235004560 putative transporter; Provisional; Region: PRK11660 573235004561 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 573235004562 Sulfate transporter family; Region: Sulfate_transp; pfam00916 573235004563 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 573235004564 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 573235004565 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 573235004566 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 573235004567 active site 573235004568 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 573235004569 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 573235004570 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 573235004571 outer membrane lipoprotein LolB; Region: lolB; TIGR00548 573235004572 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 573235004573 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 573235004574 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 573235004575 tRNA; other site 573235004576 putative tRNA binding site [nucleotide binding]; other site 573235004577 putative NADP binding site [chemical binding]; other site 573235004578 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 573235004579 peptide chain release factor 1; Validated; Region: prfA; PRK00591 573235004580 This domain is found in peptide chain release factors; Region: PCRF; smart00937 573235004581 RF-1 domain; Region: RF-1; pfam00472 573235004582 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 573235004583 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573235004584 hypothetical protein; Provisional; Region: PRK10278 573235004585 hypothetical protein; Provisional; Region: PRK10941 573235004586 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 573235004587 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 573235004588 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 573235004589 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 573235004590 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 573235004591 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 573235004592 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 573235004593 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 573235004594 cation transport regulator; Reviewed; Region: chaB; PRK09582 573235004595 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 573235004596 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 573235004597 putative active site pocket [active] 573235004598 dimerization interface [polypeptide binding]; other site 573235004599 putative catalytic residue [active] 573235004600 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 573235004601 putative invasin; Provisional; Region: PRK10177 573235004602 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 573235004603 transcriptional regulator NarL; Provisional; Region: PRK10651 573235004604 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573235004605 active site 573235004606 phosphorylation site [posttranslational modification] 573235004607 intermolecular recognition site; other site 573235004608 dimerization interface [polypeptide binding]; other site 573235004609 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573235004610 DNA binding residues [nucleotide binding] 573235004611 dimerization interface [polypeptide binding]; other site 573235004612 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 573235004613 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 573235004614 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573235004615 dimerization interface [polypeptide binding]; other site 573235004616 Histidine kinase; Region: HisKA_3; pfam07730 573235004617 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573235004618 ATP binding site [chemical binding]; other site 573235004619 Mg2+ binding site [ion binding]; other site 573235004620 G-X-G motif; other site 573235004621 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 573235004622 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 573235004623 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 573235004624 [4Fe-4S] binding site [ion binding]; other site 573235004625 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 573235004626 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 573235004627 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 573235004628 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 573235004629 molybdopterin cofactor binding site; other site 573235004630 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 573235004631 4Fe-4S binding domain; Region: Fer4; cl02805 573235004632 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 573235004633 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 573235004634 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 573235004635 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 573235004636 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 573235004637 putative active site [active] 573235004638 putative substrate binding site [chemical binding]; other site 573235004639 putative cosubstrate binding site; other site 573235004640 catalytic site [active] 573235004641 SEC-C motif; Region: SEC-C; pfam02810 573235004642 hypothetical protein; Provisional; Region: PRK04233 573235004643 hypothetical protein; Provisional; Region: PRK10279 573235004644 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 573235004645 active site 573235004646 nucleophile elbow; other site 573235004647 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573235004648 active site 573235004649 response regulator of RpoS; Provisional; Region: PRK10693 573235004650 phosphorylation site [posttranslational modification] 573235004651 intermolecular recognition site; other site 573235004652 dimerization interface [polypeptide binding]; other site 573235004653 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 573235004654 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 573235004655 active site 573235004656 tetramer interface; other site 573235004657 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 573235004658 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 573235004659 thymidine kinase; Provisional; Region: PRK04296 573235004660 predicted transposase, partial 573235004661 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 573235004662 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 573235004663 putative catalytic cysteine [active] 573235004664 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 573235004665 putative active site [active] 573235004666 metal binding site [ion binding]; metal-binding site 573235004667 hypothetical protein; Provisional; Region: PRK11111 573235004668 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 573235004669 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 573235004670 peptide binding site [polypeptide binding]; other site 573235004671 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 573235004672 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573235004673 dimer interface [polypeptide binding]; other site 573235004674 conserved gate region; other site 573235004675 putative PBP binding loops; other site 573235004676 ABC-ATPase subunit interface; other site 573235004677 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 573235004678 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 573235004679 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573235004680 dimer interface [polypeptide binding]; other site 573235004681 conserved gate region; other site 573235004682 putative PBP binding loops; other site 573235004683 ABC-ATPase subunit interface; other site 573235004684 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 573235004685 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 573235004686 Walker A/P-loop; other site 573235004687 ATP binding site [chemical binding]; other site 573235004688 Q-loop/lid; other site 573235004689 ABC transporter signature motif; other site 573235004690 Walker B; other site 573235004691 D-loop; other site 573235004692 H-loop/switch region; other site 573235004693 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 573235004694 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 573235004695 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 573235004696 Walker A/P-loop; other site 573235004697 ATP binding site [chemical binding]; other site 573235004698 Q-loop/lid; other site 573235004699 ABC transporter signature motif; other site 573235004700 Walker B; other site 573235004701 D-loop; other site 573235004702 H-loop/switch region; other site 573235004703 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 573235004704 dsDNA-mimic protein; Reviewed; Region: PRK05094 573235004705 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 573235004706 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 573235004707 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 573235004708 putative active site [active] 573235004709 catalytic site [active] 573235004710 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 573235004711 putative active site [active] 573235004712 catalytic site [active] 573235004713 voltage-gated potassium channel; Provisional; Region: PRK10537 573235004714 Ion channel; Region: Ion_trans_2; pfam07885 573235004715 TrkA-N domain; Region: TrkA_N; pfam02254 573235004716 YciI-like protein; Reviewed; Region: PRK11370 573235004717 transport protein TonB; Provisional; Region: PRK10819 573235004718 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 573235004719 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 573235004720 intracellular septation protein A; Reviewed; Region: PRK00259 573235004721 hypothetical protein; Provisional; Region: PRK02868 573235004722 outer membrane protein W; Provisional; Region: PRK10959 573235004723 Prophage ECO26_P08, lambda-like phage 573235004724 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 573235004725 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 573235004726 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 573235004727 dimer interface [polypeptide binding]; other site 573235004728 active site 573235004729 Int/Topo IB signature motif; other site 573235004730 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 573235004731 active site 573235004732 catalytic site [active] 573235004733 substrate binding site [chemical binding]; other site 573235004734 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 573235004735 DicB protein; Region: DicB; pfam05358 573235004736 transcriptional repressor DicA; Reviewed; Region: PRK09706 573235004737 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573235004738 sequence-specific DNA binding site [nucleotide binding]; other site 573235004739 salt bridge; other site 573235004740 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 573235004741 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 573235004742 Pyocin large subunit [General function prediction only]; Region: COG5529 573235004743 Helix-turn-helix domain; Region: HTH_36; pfam13730 573235004744 primosomal protein DnaI; Provisional; Region: PRK02854 573235004745 Protein of unknown function (DUF1627); Region: DUF1627; pfam07789 573235004746 Prophage ECO26_P08; fimbrial minor pilin protein, N-terminal part 573235004747 Prophage ECO26_P08; fimbrial minor pilin protein partial fragment 573235004748 Accessory colonization factor AcfC, contains ABC-type periplasmic domain [General function prediction only]; Region: AcfC; COG4588 573235004749 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 573235004750 Hok/gef family; Region: HOK_GEF; pfam01848 573235004751 Protein of unknown function (DUF968); Region: DUF968; pfam06147 573235004752 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 573235004753 Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323 573235004754 Prophage ECO26_P08; predicted TciA/TerB, N-terminal fragment 573235004755 Prophage ECO26_P08; predicted TciA/TerB, C-terminal fragment 573235004756 Protein of unknown function (DUF3927); Region: DUF3927; pfam13064 573235004757 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 573235004758 Domain of unknown function (DUF303); Region: DUF303; pfam03629 573235004759 Lysis protein S; Region: Lysis_S; pfam04971 573235004760 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 573235004761 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 573235004762 catalytic residues [active] 573235004763 Prophage ECO26_P08; antirepressor, C-terminal part 573235004764 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 573235004765 Transposase; Region: HTH_Tnp_1; pfam01527 573235004766 Prophage ECO26_P08; predicted transposase OrfB protein of insertion sequence IS600, C-terminal fragment 573235004767 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 573235004768 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 573235004769 Prophage ECO26_P08; T3SS effector NleA, C-terminal part 573235004770 Prophage ECO26_P08; T3SS effector NleA, N-terminal part 573235004771 Prophage ECO26_P08; predicted integrase, C-terminal part 573235004772 hypothetical protein; Provisional; Region: PHA03031 573235004773 Prophage ECO26_P08; predicted transposase of insertion sequence IS604, partial 573235004774 Prophage ECO26_P08; predicted transposase of insertion sequence IS604, partial 573235004775 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 573235004776 IpaB/EvcA family; Region: IpaB_EvcA; pfam03278 573235004777 Prophage ECO26_P08; predicted transposase of insertion sequence IS630, partial 573235004778 Prophage ECO26_P08; predicted transposase of insertion sequence IS630, partial 573235004779 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 573235004780 outer membrane protein W, C-terminal fragment 573235004781 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 573235004782 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 573235004783 dimerization interface [polypeptide binding]; other site 573235004784 metal binding site [ion binding]; metal-binding site 573235004785 General stress protein [General function prediction only]; Region: GsiB; COG3729 573235004786 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 573235004787 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 573235004788 substrate binding site [chemical binding]; other site 573235004789 active site 573235004790 catalytic residues [active] 573235004791 heterodimer interface [polypeptide binding]; other site 573235004792 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 573235004793 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 573235004794 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573235004795 catalytic residue [active] 573235004796 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 573235004797 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 573235004798 active site 573235004799 ribulose/triose binding site [chemical binding]; other site 573235004800 phosphate binding site [ion binding]; other site 573235004801 substrate (anthranilate) binding pocket [chemical binding]; other site 573235004802 product (indole) binding pocket [chemical binding]; other site 573235004803 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 573235004804 active site 573235004805 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 573235004806 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 573235004807 glutamine binding [chemical binding]; other site 573235004808 catalytic triad [active] 573235004809 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 573235004810 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 573235004811 anthranilate synthase component I; Provisional; Region: PRK13564 573235004812 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 573235004813 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 573235004814 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 573235004815 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 573235004816 active site 573235004817 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 573235004818 hypothetical protein; Provisional; Region: PRK11630 573235004819 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 573235004820 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 573235004821 RNA binding surface [nucleotide binding]; other site 573235004822 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 573235004823 probable active site [active] 573235004824 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 573235004825 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 573235004826 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 573235004827 homodimer interface [polypeptide binding]; other site 573235004828 Walker A motif; other site 573235004829 ATP binding site [chemical binding]; other site 573235004830 hydroxycobalamin binding site [chemical binding]; other site 573235004831 Walker B motif; other site 573235004832 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 573235004833 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 573235004834 NADP binding site [chemical binding]; other site 573235004835 homodimer interface [polypeptide binding]; other site 573235004836 active site 573235004837 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 573235004838 putative inner membrane peptidase; Provisional; Region: PRK11778 573235004839 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 573235004840 tandem repeat interface [polypeptide binding]; other site 573235004841 oligomer interface [polypeptide binding]; other site 573235004842 active site residues [active] 573235004843 hypothetical protein; Provisional; Region: PRK11037 573235004844 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 573235004845 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 573235004846 active site 573235004847 interdomain interaction site; other site 573235004848 putative metal-binding site [ion binding]; other site 573235004849 nucleotide binding site [chemical binding]; other site 573235004850 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 573235004851 domain I; other site 573235004852 DNA binding groove [nucleotide binding] 573235004853 phosphate binding site [ion binding]; other site 573235004854 domain II; other site 573235004855 domain III; other site 573235004856 nucleotide binding site [chemical binding]; other site 573235004857 catalytic site [active] 573235004858 domain IV; other site 573235004859 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 573235004860 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 573235004861 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 573235004862 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 573235004863 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 573235004864 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573235004865 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 573235004866 substrate binding site [chemical binding]; other site 573235004867 putative dimerization interface [polypeptide binding]; other site 573235004868 conserved predicted protein, C-terminal fragment 573235004869 aconitate hydratase; Validated; Region: PRK09277 573235004870 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 573235004871 substrate binding site [chemical binding]; other site 573235004872 ligand binding site [chemical binding]; other site 573235004873 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 573235004874 substrate binding site [chemical binding]; other site 573235004875 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 573235004876 dimerization interface [polypeptide binding]; other site 573235004877 active site 573235004878 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 573235004879 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 573235004880 active site 573235004881 Predicted membrane protein [Function unknown]; Region: COG3771 573235004882 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 573235004883 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 573235004884 TPR motif; other site 573235004885 binding surface 573235004886 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573235004887 binding surface 573235004888 TPR motif; other site 573235004889 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 573235004890 active site 573235004891 dimer interface [polypeptide binding]; other site 573235004892 translation initiation factor Sui1; Validated; Region: PRK06824 573235004893 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 573235004894 putative rRNA binding site [nucleotide binding]; other site 573235004895 lipoprotein; Provisional; Region: PRK10540 573235004896 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 573235004897 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 573235004898 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 573235004899 hypothetical protein; Provisional; Region: PRK13658 573235004900 RNase II stability modulator; Provisional; Region: PRK10060 573235004901 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573235004902 putative active site [active] 573235004903 heme pocket [chemical binding]; other site 573235004904 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573235004905 metal binding site [ion binding]; metal-binding site 573235004906 active site 573235004907 I-site; other site 573235004908 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 573235004909 exoribonuclease II; Provisional; Region: PRK05054 573235004910 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 573235004911 RNB domain; Region: RNB; pfam00773 573235004912 S1 RNA binding domain; Region: S1; pfam00575 573235004913 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 573235004914 Uncharacterized conserved protein [Function unknown]; Region: COG2128 573235004915 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 573235004916 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 573235004917 NAD binding site [chemical binding]; other site 573235004918 homotetramer interface [polypeptide binding]; other site 573235004919 homodimer interface [polypeptide binding]; other site 573235004920 substrate binding site [chemical binding]; other site 573235004921 active site 573235004922 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 573235004923 putative active site [active] 573235004924 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 573235004925 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 573235004926 Walker A/P-loop; other site 573235004927 ATP binding site [chemical binding]; other site 573235004928 Q-loop/lid; other site 573235004929 ABC transporter signature motif; other site 573235004930 Walker B; other site 573235004931 D-loop; other site 573235004932 H-loop/switch region; other site 573235004933 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 573235004934 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 573235004935 Walker A/P-loop; other site 573235004936 ATP binding site [chemical binding]; other site 573235004937 Q-loop/lid; other site 573235004938 ABC transporter signature motif; other site 573235004939 Walker B; other site 573235004940 D-loop; other site 573235004941 H-loop/switch region; other site 573235004942 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 573235004943 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 573235004944 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 573235004945 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573235004946 dimer interface [polypeptide binding]; other site 573235004947 conserved gate region; other site 573235004948 putative PBP binding loops; other site 573235004949 ABC-ATPase subunit interface; other site 573235004950 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 573235004951 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573235004952 dimer interface [polypeptide binding]; other site 573235004953 conserved gate region; other site 573235004954 putative PBP binding loops; other site 573235004955 ABC-ATPase subunit interface; other site 573235004956 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 573235004957 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 573235004958 peptide binding site [polypeptide binding]; other site 573235004959 Protein of unknown function (DUF2543); Region: DUF2543; pfam10820 573235004960 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 573235004961 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 573235004962 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 573235004963 gamma-glutamyl-gamma-aminobutyrate hydrolase; Provisional; Region: puuD; PRK11366 573235004964 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 573235004965 catalytic triad [active] 573235004966 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 573235004967 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573235004968 non-specific DNA binding site [nucleotide binding]; other site 573235004969 salt bridge; other site 573235004970 sequence-specific DNA binding site [nucleotide binding]; other site 573235004971 Cupin domain; Region: Cupin_2; pfam07883 573235004972 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 573235004973 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 573235004974 NAD(P) binding site [chemical binding]; other site 573235004975 catalytic residues [active] 573235004976 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 573235004977 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 573235004978 4-aminobutyrate transaminase; Provisional; Region: PRK09792 573235004979 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 573235004980 inhibitor-cofactor binding pocket; inhibition site 573235004981 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573235004982 catalytic residue [active] 573235004983 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 573235004984 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573235004985 Walker A motif; other site 573235004986 ATP binding site [chemical binding]; other site 573235004987 Walker B motif; other site 573235004988 arginine finger; other site 573235004989 phage shock protein PspA; Provisional; Region: PRK10698 573235004990 phage shock protein B; Provisional; Region: pspB; PRK09458 573235004991 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 573235004992 phage shock protein C; Region: phageshock_pspC; TIGR02978 573235004993 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 573235004994 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 573235004995 active site residue [active] 573235004996 predicted glucosyltransferase, N-terminal fragment 573235004997 predicted glucosyltransferase, C-terminal fragment 573235004998 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 573235004999 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 573235005000 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 573235005001 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573235005002 dimer interface [polypeptide binding]; other site 573235005003 conserved gate region; other site 573235005004 putative PBP binding loops; other site 573235005005 ABC-ATPase subunit interface; other site 573235005006 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573235005007 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573235005008 dimer interface [polypeptide binding]; other site 573235005009 conserved gate region; other site 573235005010 putative PBP binding loops; other site 573235005011 ABC-ATPase subunit interface; other site 573235005012 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 573235005013 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 573235005014 putative NAD(P) binding site [chemical binding]; other site 573235005015 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 573235005016 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 573235005017 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 573235005018 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 573235005019 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 573235005020 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 573235005021 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 573235005022 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 573235005023 beta-phosphoglucomutase; Region: bPGM; TIGR01990 573235005024 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573235005025 motif II; other site 573235005026 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 573235005027 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 573235005028 Walker A/P-loop; other site 573235005029 ATP binding site [chemical binding]; other site 573235005030 Q-loop/lid; other site 573235005031 ABC transporter signature motif; other site 573235005032 Walker B; other site 573235005033 D-loop; other site 573235005034 H-loop/switch region; other site 573235005035 TOBE domain; Region: TOBE_2; pfam08402 573235005036 Outer membrane protein G (OmpG); Region: Porin_OmpG; pfam09381 573235005037 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573235005038 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573235005039 DNA binding site [nucleotide binding] 573235005040 domain linker motif; other site 573235005041 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 573235005042 putative dimerization interface [polypeptide binding]; other site 573235005043 putative ligand binding site [chemical binding]; other site 573235005044 Predicted ATPase [General function prediction only]; Region: COG3106 573235005045 Predicted membrane protein [Function unknown]; Region: COG3768 573235005046 TIGR01620 family protein; Region: hyp_HI0043 573235005047 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 573235005048 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 573235005049 putative aromatic amino acid binding site; other site 573235005050 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573235005051 Walker A motif; other site 573235005052 ATP binding site [chemical binding]; other site 573235005053 Walker B motif; other site 573235005054 arginine finger; other site 573235005055 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 573235005056 dimer interface [polypeptide binding]; other site 573235005057 catalytic triad [active] 573235005058 peroxidatic and resolving cysteines [active] 573235005059 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 573235005060 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 573235005061 active site 573235005062 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 573235005063 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 573235005064 putative active site [active] 573235005065 Zn binding site [ion binding]; other site 573235005066 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 573235005067 NADH(P)-binding; Region: NAD_binding_10; pfam13460 573235005068 putative NAD(P) binding site [chemical binding]; other site 573235005069 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 573235005070 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 573235005071 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 573235005072 Transcriptional regulator [Transcription]; Region: LysR; COG0583 573235005073 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573235005074 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 573235005075 putative effector binding pocket; other site 573235005076 putative dimerization interface [polypeptide binding]; other site 573235005077 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 573235005078 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 573235005079 peptide binding site [polypeptide binding]; other site 573235005080 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 573235005081 Mechanosensitive ion channel; Region: MS_channel; pfam00924 573235005082 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 573235005083 universal stress protein UspE; Provisional; Region: PRK11175 573235005084 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 573235005085 Ligand Binding Site [chemical binding]; other site 573235005086 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 573235005087 Ligand Binding Site [chemical binding]; other site 573235005088 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 573235005089 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 573235005090 ligand binding site [chemical binding]; other site 573235005091 flexible hinge region; other site 573235005092 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 573235005093 putative switch regulator; other site 573235005094 non-specific DNA interactions [nucleotide binding]; other site 573235005095 DNA binding site [nucleotide binding] 573235005096 sequence specific DNA binding site [nucleotide binding]; other site 573235005097 putative cAMP binding site [chemical binding]; other site 573235005098 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 573235005099 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 573235005100 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 573235005101 DNA binding site [nucleotide binding] 573235005102 active site 573235005103 putative aminobenzoyl-glutamate transporter; Provisional; Region: abgT; PRK11339 573235005104 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 573235005105 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 573235005106 amidohydrolase; Region: amidohydrolases; TIGR01891 573235005107 putative metal binding site [ion binding]; other site 573235005108 M20 Peptidases Aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase from bacteria and archaea; Region: M20_Acy1_IAAspH_bact; cd05665 573235005109 amidohydrolase; Region: amidohydrolases; TIGR01891 573235005110 putative metal binding site [ion binding]; other site 573235005111 dimer interface [polypeptide binding]; other site 573235005112 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 573235005113 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573235005114 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 573235005115 putative substrate binding pocket [chemical binding]; other site 573235005116 putative dimerization interface [polypeptide binding]; other site 573235005117 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 573235005118 Smr domain; Region: Smr; pfam01713 573235005119 PAS domain S-box; Region: sensory_box; TIGR00229 573235005120 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573235005121 putative active site [active] 573235005122 heme pocket [chemical binding]; other site 573235005123 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 573235005124 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573235005125 metal binding site [ion binding]; metal-binding site 573235005126 active site 573235005127 I-site; other site 573235005128 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 573235005129 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 573235005130 Cl binding site [ion binding]; other site 573235005131 oligomer interface [polypeptide binding]; other site 573235005132 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 573235005133 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 573235005134 ATP binding site [chemical binding]; other site 573235005135 Mg++ binding site [ion binding]; other site 573235005136 motif III; other site 573235005137 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573235005138 nucleotide binding region [chemical binding]; other site 573235005139 ATP-binding site [chemical binding]; other site 573235005140 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 573235005141 putative RNA binding site [nucleotide binding]; other site 573235005142 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 573235005143 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 573235005144 Ligand Binding Site [chemical binding]; other site 573235005145 Prophage ECO26_P09, lambda-like phage 573235005146 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 573235005147 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 573235005148 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 573235005149 Int/Topo IB signature motif; other site 573235005150 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 573235005151 hypothetical protein; Provisional; Region: PRK09750 573235005152 Prophage ECO26_P09; restriction alleviation protein, N-terminal fragment 573235005153 recombination and repair protein RecT; Reviewed; Region: recT; PRK09846 573235005154 exonuclease VIII; Reviewed; Region: PRK09709 573235005155 Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630 573235005156 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 573235005157 hypothetical protein; Reviewed; Region: PRK09790 573235005158 FtsZ inhibitor protein; Reviewed; Region: kil; PRK11354 573235005159 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 573235005160 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573235005161 non-specific DNA binding site [nucleotide binding]; other site 573235005162 salt bridge; other site 573235005163 transcriptional repressor DicA; Reviewed; Region: PRK09706 573235005164 sequence-specific DNA binding site [nucleotide binding]; other site 573235005165 Helix-turn-helix domain; Region: HTH_17; cl17695 573235005166 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 573235005167 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3756 573235005168 primosomal protein DnaI; Provisional; Region: PRK02854 573235005169 putative replication protein; Provisional; Region: PRK12377 573235005170 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573235005171 Walker A motif; other site 573235005172 ATP binding site [chemical binding]; other site 573235005173 Protein of unknown function (DUF1627); Region: DUF1627; pfam07789 573235005174 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 573235005175 Domain of unknown function (DUF4406); Region: DUF4406; pfam14359 573235005176 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 573235005177 Prophage ECO26_P09; conserved predicted protein, C-terminal part 573235005178 Protein of unknown function (DUF551); Region: DUF551; pfam04448 573235005179 Hok/gef family; Region: HOK_GEF; pfam01848 573235005180 Protein of unknown function (DUF968); Region: DUF968; pfam06147 573235005181 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 573235005182 Antitermination protein; Region: Antiterm; pfam03589 573235005183 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 573235005184 Prophage ECO26_P09; predicted TciA/TerB, C-terminal part 573235005185 Protein of unknown function (DUF3927); Region: DUF3927; pfam13064 573235005186 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 573235005187 Domain of unknown function (DUF303); Region: DUF303; pfam03629 573235005188 Lysis protein S; Region: Lysis_S; pfam04971 573235005189 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 573235005190 catalytic residues [active] 573235005191 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 573235005192 Lipoprotein Rz1 precursor; Region: Rz1; pfam06085 573235005193 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646 573235005194 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 573235005195 ORF11CD3 domain; Region: ORF11CD3; pfam10549 573235005196 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 573235005197 Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471 573235005198 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 573235005199 gpW; Region: gpW; pfam02831 573235005200 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 573235005201 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 573235005202 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 573235005203 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 573235005204 tandem repeat interface [polypeptide binding]; other site 573235005205 oligomer interface [polypeptide binding]; other site 573235005206 active site residues [active] 573235005207 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 573235005208 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 573235005209 DNA packaging protein FI; Region: Packaging_FI; pfam14000 573235005210 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 573235005211 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 573235005212 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 573235005213 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 573235005214 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 573235005215 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894 573235005216 Minor tail protein T; Region: Phage_tail_T; cl05636 573235005217 Phage-related minor tail protein [Function unknown]; Region: COG5281 573235005218 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 573235005219 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 573235005220 Phage-related protein [Function unknown]; Region: COG4718 573235005221 Phage-related protein [Function unknown]; Region: gp18; COG4672 573235005222 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 573235005223 MPN+ (JAMM) motif; other site 573235005224 Zinc-binding site [ion binding]; other site 573235005225 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 573235005226 NlpC/P60 family; Region: NLPC_P60; cl17555 573235005227 Phage-related protein, tail component [Function unknown]; Region: COG4723 573235005228 Phage-related protein, tail component [Function unknown]; Region: COG4733 573235005229 Putative phage tail protein; Region: Phage-tail_3; pfam13550 573235005230 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 573235005231 Fibronectin type III protein; Region: DUF3672; pfam12421 573235005232 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 573235005233 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 573235005234 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 573235005235 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 573235005236 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 573235005237 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 573235005238 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 573235005239 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 573235005240 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 573235005241 Ligand Binding Site [chemical binding]; other site 573235005242 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 573235005243 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 573235005244 trimer interface [polypeptide binding]; other site 573235005245 eyelet of channel; other site 573235005246 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 573235005247 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 573235005248 dimer interface [polypeptide binding]; other site 573235005249 PYR/PP interface [polypeptide binding]; other site 573235005250 TPP binding site [chemical binding]; other site 573235005251 substrate binding site [chemical binding]; other site 573235005252 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 573235005253 Domain of unknown function; Region: EKR; smart00890 573235005254 4Fe-4S binding domain; Region: Fer4_6; pfam12837 573235005255 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 573235005256 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 573235005257 TPP-binding site [chemical binding]; other site 573235005258 dimer interface [polypeptide binding]; other site 573235005259 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 573235005260 Domain of unknown function (DUF333); Region: DUF333; pfam03891 573235005261 heat-inducible protein; Provisional; Region: PRK10449 573235005262 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 573235005263 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 573235005264 putative ligand binding site [chemical binding]; other site 573235005265 putative NAD binding site [chemical binding]; other site 573235005266 catalytic site [active] 573235005267 hypothetical protein; Provisional; Region: PRK10695 573235005268 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 573235005269 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 573235005270 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 573235005271 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573235005272 Escherichia coli NAD+-dependent phenylacetaldehyde dehydrogenase PadA-like; Region: ALDH_PADH_NahF; cd07113 573235005273 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 573235005274 NAD(P) binding site [chemical binding]; other site 573235005275 catalytic residues [active] 573235005276 tyramine oxidase; Provisional; Region: tynA; PRK14696 573235005277 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 573235005278 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 573235005279 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 573235005280 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 573235005281 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 573235005282 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 573235005283 substrate binding site [chemical binding]; other site 573235005284 dimer interface [polypeptide binding]; other site 573235005285 NADP binding site [chemical binding]; other site 573235005286 catalytic residues [active] 573235005287 MaoC_C The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452 573235005288 substrate binding site [chemical binding]; other site 573235005289 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 573235005290 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 573235005291 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 573235005292 phenylacetate-CoA oxygenase, PaaI subunit; Region: PA_CoA_Oxy3; TIGR02158 573235005293 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 573235005294 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 573235005295 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 573235005296 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 573235005297 FAD binding pocket [chemical binding]; other site 573235005298 FAD binding motif [chemical binding]; other site 573235005299 phosphate binding motif [ion binding]; other site 573235005300 beta-alpha-beta structure motif; other site 573235005301 NAD(p) ribose binding residues [chemical binding]; other site 573235005302 NAD binding pocket [chemical binding]; other site 573235005303 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 573235005304 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 573235005305 catalytic loop [active] 573235005306 iron binding site [ion binding]; other site 573235005307 enoyl-CoA hydratase-isomerase; Provisional; Region: PRK09674 573235005308 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 573235005309 substrate binding site [chemical binding]; other site 573235005310 oxyanion hole (OAH) forming residues; other site 573235005311 trimer interface [polypeptide binding]; other site 573235005312 enoyl-CoA hydratase; Provisional; Region: PRK08140 573235005313 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 573235005314 substrate binding site [chemical binding]; other site 573235005315 oxyanion hole (OAH) forming residues; other site 573235005316 trimer interface [polypeptide binding]; other site 573235005317 3-hydroxyacyl-CoA dehydrogenase PaaC; Region: PaaC-3OHAcCoADH; TIGR02279 573235005318 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 573235005319 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 573235005320 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 573235005321 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 573235005322 CoenzymeA binding site [chemical binding]; other site 573235005323 subunit interaction site [polypeptide binding]; other site 573235005324 PHB binding site; other site 573235005325 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 573235005326 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 573235005327 dimer interface [polypeptide binding]; other site 573235005328 active site 573235005329 Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913 573235005330 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 573235005331 active site 573235005332 AMP binding site [chemical binding]; other site 573235005333 homodimer interface [polypeptide binding]; other site 573235005334 acyl-activating enzyme (AAE) consensus motif; other site 573235005335 CoA binding site [chemical binding]; other site 573235005336 PaaX-like protein; Region: PaaX; pfam07848 573235005337 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 573235005338 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 573235005339 phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287 573235005340 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 573235005341 putative trimer interface [polypeptide binding]; other site 573235005342 putative metal binding site [ion binding]; other site 573235005343 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 573235005344 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 573235005345 active site 573235005346 catalytic tetrad [active] 573235005347 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 573235005348 Protein of unknown function (DUF2773); Region: DUF2773; pfam10971 573235005349 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 573235005350 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 573235005351 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 573235005352 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 573235005353 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 573235005354 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573235005355 S-adenosylmethionine binding site [chemical binding]; other site 573235005356 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 573235005357 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 573235005358 active site 573235005359 Dual specificity phosphatase, catalytic domain; Region: DSPc; smart00195 573235005360 active site 573235005361 catalytic residues [active] 573235005362 azoreductase; Reviewed; Region: PRK00170 573235005363 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 573235005364 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 573235005365 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573235005366 ATP binding site [chemical binding]; other site 573235005367 putative Mg++ binding site [ion binding]; other site 573235005368 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573235005369 nucleotide binding region [chemical binding]; other site 573235005370 ATP-binding site [chemical binding]; other site 573235005371 Helicase associated domain (HA2); Region: HA2; pfam04408 573235005372 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 573235005373 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 573235005374 Uncharacterized conserved protein [Function unknown]; Region: COG1434 573235005375 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 573235005376 putative active site [active] 573235005377 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 573235005378 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 573235005379 NAD binding site [chemical binding]; other site 573235005380 catalytic residues [active] 573235005381 substrate binding site [chemical binding]; other site 573235005382 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 573235005383 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 573235005384 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 573235005385 cytochrome b561; Provisional; Region: PRK11513 573235005386 hypothetical protein; Provisional; Region: PRK10040 573235005387 small toxic polypeptide; Provisional; Region: PRK09738 573235005388 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 573235005389 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 573235005390 dimer interface [polypeptide binding]; other site 573235005391 ligand binding site [chemical binding]; other site 573235005392 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573235005393 dimerization interface [polypeptide binding]; other site 573235005394 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573235005395 dimer interface [polypeptide binding]; other site 573235005396 putative CheW interface [polypeptide binding]; other site 573235005397 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 573235005398 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573235005399 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 573235005400 dimerization interface [polypeptide binding]; other site 573235005401 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 573235005402 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 573235005403 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 573235005404 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 573235005405 hypothetical protein; Provisional; Region: PRK11415 573235005406 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 573235005407 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573235005408 Coenzyme A binding pocket [chemical binding]; other site 573235005409 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 573235005410 putative trimer interface [polypeptide binding]; other site 573235005411 putative CoA binding site [chemical binding]; other site 573235005412 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 573235005413 putative trimer interface [polypeptide binding]; other site 573235005414 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 573235005415 putative CoA binding site [chemical binding]; other site 573235005416 putative trimer interface [polypeptide binding]; other site 573235005417 putative CoA binding site [chemical binding]; other site 573235005418 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 573235005419 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 573235005420 gating phenylalanine in ion channel; other site 573235005421 tellurite resistance protein TehB; Provisional; Region: PRK11207 573235005422 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573235005423 S-adenosylmethionine binding site [chemical binding]; other site 573235005424 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 573235005425 predicted transposase TnpA of insertion sequence IS609, central part 573235005426 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 573235005427 Probable transposase; Region: OrfB_IS605; pfam01385 573235005428 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 573235005429 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 573235005430 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 573235005431 benzoate transporter; Region: benE; TIGR00843 573235005432 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 573235005433 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573235005434 non-specific DNA binding site [nucleotide binding]; other site 573235005435 salt bridge; other site 573235005436 sequence-specific DNA binding site [nucleotide binding]; other site 573235005437 Cupin domain; Region: Cupin_2; pfam07883 573235005438 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 573235005439 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 573235005440 Peptidase family U32; Region: Peptidase_U32; pfam01136 573235005441 Collagenase; Region: DUF3656; pfam12392 573235005442 Protein of unknown function (DUF2554); Region: DUF2554; pfam10829 573235005443 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 573235005444 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573235005445 sequence-specific DNA binding site [nucleotide binding]; other site 573235005446 salt bridge; other site 573235005447 predicted DNA-binding transcriptional regulator/predicted amino transferase N-terminal part 573235005448 predicted DNA-binding transcriptional regulator/predicted amino transferase C-terminal part 573235005449 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 573235005450 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 573235005451 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 573235005452 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573235005453 Walker A/P-loop; other site 573235005454 ATP binding site [chemical binding]; other site 573235005455 Q-loop/lid; other site 573235005456 ABC transporter signature motif; other site 573235005457 Walker B; other site 573235005458 D-loop; other site 573235005459 H-loop/switch region; other site 573235005460 TOBE domain; Region: TOBE_2; pfam08402 573235005461 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573235005462 dimer interface [polypeptide binding]; other site 573235005463 conserved gate region; other site 573235005464 putative PBP binding loops; other site 573235005465 ABC-ATPase subunit interface; other site 573235005466 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 573235005467 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573235005468 ABC-ATPase subunit interface; other site 573235005469 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 573235005470 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 573235005471 tetrameric interface [polypeptide binding]; other site 573235005472 NAD binding site [chemical binding]; other site 573235005473 catalytic residues [active] 573235005474 substrate binding site [chemical binding]; other site 573235005475 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 573235005476 trimer interface [polypeptide binding]; other site 573235005477 active site 573235005478 substrate binding site [chemical binding]; other site 573235005479 CoA binding site [chemical binding]; other site 573235005480 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 573235005481 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 573235005482 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 573235005483 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 573235005484 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 573235005485 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 573235005486 Prostaglandin dehydrogenases; Region: PGDH; cd05288 573235005487 NAD(P) binding site [chemical binding]; other site 573235005488 substrate binding site [chemical binding]; other site 573235005489 dimer interface [polypeptide binding]; other site 573235005490 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 573235005491 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573235005492 DNA-binding site [nucleotide binding]; DNA binding site 573235005493 FCD domain; Region: FCD; pfam07729 573235005494 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 573235005495 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 573235005496 N-terminal plug; other site 573235005497 ligand-binding site [chemical binding]; other site 573235005498 PQQ-like domain; Region: PQQ_2; pfam13360 573235005499 L-asparagine permease; Provisional; Region: PRK15049 573235005500 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 573235005501 C-terminal domain interface [polypeptide binding]; other site 573235005502 GSH binding site (G-site) [chemical binding]; other site 573235005503 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 573235005504 dimer interface [polypeptide binding]; other site 573235005505 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 573235005506 dimer interface [polypeptide binding]; other site 573235005507 N-terminal domain interface [polypeptide binding]; other site 573235005508 substrate binding pocket (H-site) [chemical binding]; other site 573235005509 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 573235005510 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 573235005511 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 573235005512 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 573235005513 PAAR motif; Region: PAAR_motif; cl15808 573235005514 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 573235005515 RHS Repeat; Region: RHS_repeat; pfam05593 573235005516 RHS Repeat; Region: RHS_repeat; pfam05593 573235005517 RHS Repeat; Region: RHS_repeat; pfam05593 573235005518 RHS Repeat; Region: RHS_repeat; pfam05593 573235005519 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 573235005520 RHS Repeat; Region: RHS_repeat; pfam05593 573235005521 RHS Repeat; Region: RHS_repeat; pfam05593 573235005522 RHS protein; Region: RHS; pfam03527 573235005523 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 573235005524 RhsE, IS677, predicted H repeat-associated protein, N-terminal part 573235005525 RhsE, IS677, predicted H repeat-associated protein, C-terminal part 573235005526 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 573235005527 N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047 573235005528 hypothetical protein; Provisional; Region: PRK10281 573235005529 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 573235005530 nitrate reductase 2 subunit delta; Provisional; Region: PRK15054 573235005531 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 573235005532 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 573235005533 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 573235005534 [4Fe-4S] binding site [ion binding]; other site 573235005535 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 573235005536 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 573235005537 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 573235005538 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 573235005539 molybdopterin cofactor binding site; other site 573235005540 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 573235005541 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 573235005542 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573235005543 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 573235005544 aromatic amino acid exporter; Provisional; Region: PRK11689 573235005545 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 573235005546 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 573235005547 [4Fe-4S] binding site [ion binding]; other site 573235005548 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 573235005549 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 573235005550 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 573235005551 molybdopterin cofactor binding site; other site 573235005552 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 573235005553 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 573235005554 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 573235005555 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 573235005556 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 573235005557 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573235005558 non-specific DNA binding site [nucleotide binding]; other site 573235005559 salt bridge; other site 573235005560 sequence-specific DNA binding site [nucleotide binding]; other site 573235005561 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 573235005562 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 573235005563 NAD binding site [chemical binding]; other site 573235005564 substrate binding site [chemical binding]; other site 573235005565 catalytic Zn binding site [ion binding]; other site 573235005566 tetramer interface [polypeptide binding]; other site 573235005567 structural Zn binding site [ion binding]; other site 573235005568 malate dehydrogenase; Provisional; Region: PRK13529 573235005569 Malic enzyme, N-terminal domain; Region: malic; pfam00390 573235005570 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 573235005571 NAD(P) binding site [chemical binding]; other site 573235005572 30S ribosomal subunit S22; Reviewed; Region: rpsV; PRK10057 573235005573 Putative biofilm-dependent modulation protein; Region: BDM; cl11581 573235005574 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 573235005575 D-ala-D-ala transporter subunit DdpF, ATP-binding component of ABC superfamily, C-terminal part 573235005576 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 573235005577 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 573235005578 Walker A/P-loop; other site 573235005579 ATP binding site [chemical binding]; other site 573235005580 Q-loop/lid; other site 573235005581 ABC transporter signature motif; other site 573235005582 Walker B; other site 573235005583 D-loop; other site 573235005584 H-loop/switch region; other site 573235005585 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 573235005586 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 573235005587 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 573235005588 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573235005589 dimer interface [polypeptide binding]; other site 573235005590 conserved gate region; other site 573235005591 putative PBP binding loops; other site 573235005592 ABC-ATPase subunit interface; other site 573235005593 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 573235005594 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573235005595 dimer interface [polypeptide binding]; other site 573235005596 conserved gate region; other site 573235005597 putative PBP binding loops; other site 573235005598 ABC-ATPase subunit interface; other site 573235005599 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 573235005600 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 573235005601 D-alanyl-D-alanine dipeptidase; Provisional; Region: PRK10178 573235005602 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 573235005603 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573235005604 putative active site [active] 573235005605 heme pocket [chemical binding]; other site 573235005606 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573235005607 putative active site [active] 573235005608 heme pocket [chemical binding]; other site 573235005609 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573235005610 metal binding site [ion binding]; metal-binding site 573235005611 active site 573235005612 I-site; other site 573235005613 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 573235005614 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 573235005615 heme-binding site [chemical binding]; other site 573235005616 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 573235005617 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573235005618 metal binding site [ion binding]; metal-binding site 573235005619 active site 573235005620 I-site; other site 573235005621 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 573235005622 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 573235005623 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 573235005624 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 573235005625 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573235005626 catalytic residue [active] 573235005627 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 573235005628 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 573235005629 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 573235005630 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 573235005631 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 573235005632 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573235005633 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 573235005634 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 573235005635 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 573235005636 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 573235005637 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 573235005638 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573235005639 FeS/SAM binding site; other site 573235005640 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 573235005641 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 573235005642 Sulfatase; Region: Sulfatase; pfam00884 573235005643 transcriptional regulator YdeO; Provisional; Region: PRK09940 573235005644 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573235005645 putative oxidoreductase; Provisional; Region: PRK09939 573235005646 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 573235005647 putative molybdopterin cofactor binding site [chemical binding]; other site 573235005648 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 573235005649 putative molybdopterin cofactor binding site; other site 573235005650 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 573235005651 mannosyl binding site [chemical binding]; other site 573235005652 Fimbrial protein; Region: Fimbrial; pfam00419 573235005653 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 573235005654 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 573235005655 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 573235005656 PapC N-terminal domain; Region: PapC_N; pfam13954 573235005657 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 573235005658 PapC C-terminal domain; Region: PapC_C; pfam13953 573235005659 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 573235005660 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 573235005661 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 573235005662 Fimbrial protein; Region: Fimbrial; cl01416 573235005663 predicted transcriptional regulator, partial 573235005664 HipA N-terminal domain; Region: Couple_hipA; pfam13657 573235005665 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 573235005666 HipA-like N-terminal domain; Region: HipA_N; pfam07805 573235005667 HipA-like C-terminal domain; Region: HipA_C; pfam07804 573235005668 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 573235005669 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573235005670 non-specific DNA binding site [nucleotide binding]; other site 573235005671 salt bridge; other site 573235005672 sequence-specific DNA binding site [nucleotide binding]; other site 573235005673 AidA-I related adhesin, partial 573235005674 AidA-I related adhesin, partial 573235005675 putative lipoprotein; Provisional; Region: PRK09707 573235005676 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 573235005677 predicted sugar kinase, C-terminal part 573235005678 predicted sugar kinase, N-terminal part 573235005679 transcriptional regulator LsrR; Provisional; Region: PRK15418 573235005680 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 573235005681 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 573235005682 autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439 573235005683 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 573235005684 Walker A/P-loop; other site 573235005685 ATP binding site [chemical binding]; other site 573235005686 Q-loop/lid; other site 573235005687 ABC transporter signature motif; other site 573235005688 Walker B; other site 573235005689 D-loop; other site 573235005690 H-loop/switch region; other site 573235005691 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 573235005692 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 573235005693 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573235005694 TM-ABC transporter signature motif; other site 573235005695 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573235005696 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 573235005697 TM-ABC transporter signature motif; other site 573235005698 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 573235005699 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 573235005700 ligand binding site [chemical binding]; other site 573235005701 autoinducer-2 (AI-2) aldolase, N-terminal part 573235005702 trans-aconitate methyltransferase, C-terminal part 573235005703 Predicted membrane protein [Function unknown]; Region: COG3781 573235005704 altronate oxidoreductase; Provisional; Region: PRK03643 573235005705 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 573235005706 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 573235005707 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 573235005708 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573235005709 metal binding site [ion binding]; metal-binding site 573235005710 active site 573235005711 I-site; other site 573235005712 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 573235005713 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 573235005714 glutaminase; Provisional; Region: PRK00971 573235005715 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 573235005716 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 573235005717 NAD(P) binding site [chemical binding]; other site 573235005718 catalytic residues [active] 573235005719 Transcriptional regulator [Transcription]; Region: LysR; COG0583 573235005720 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573235005721 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 573235005722 putative dimerization interface [polypeptide binding]; other site 573235005723 conserved predicted protein, N-terminal part 573235005724 conserved predicted protein, C-terminal part 573235005725 putative arabinose transporter; Provisional; Region: PRK03545 573235005726 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235005727 putative substrate translocation pore; other site 573235005728 inner membrane protein; Provisional; Region: PRK10995 573235005729 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 573235005730 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 573235005731 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 573235005732 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573235005733 hypothetical protein; Provisional; Region: PRK10106 573235005734 6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589 573235005735 beta-galactosidase; Region: BGL; TIGR03356 573235005736 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 573235005737 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 573235005738 trimer interface; other site 573235005739 sugar binding site [chemical binding]; other site 573235005740 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 573235005741 active site 573235005742 methionine cluster; other site 573235005743 phosphorylation site [posttranslational modification] 573235005744 metal binding site [ion binding]; metal-binding site 573235005745 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 573235005746 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 573235005747 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 573235005748 active site 573235005749 P-loop; other site 573235005750 phosphorylation site [posttranslational modification] 573235005751 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 573235005752 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573235005753 DNA-binding site [nucleotide binding]; DNA binding site 573235005754 UTRA domain; Region: UTRA; pfam07702 573235005755 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 573235005756 EamA-like transporter family; Region: EamA; pfam00892 573235005757 EamA-like transporter family; Region: EamA; pfam00892 573235005758 putative transporter; Provisional; Region: PRK10054 573235005759 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235005760 putative substrate translocation pore; other site 573235005761 conserved predicted protein, C-terminal part 573235005762 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 573235005763 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 573235005764 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 573235005765 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 573235005766 conserved predicted protein, N-terminal part 573235005767 hypothetical protein; Provisional; Region: PRK10053 573235005768 hypothetical protein; Validated; Region: PRK03657 573235005769 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 573235005770 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 573235005771 active site 573235005772 Zn binding site [ion binding]; other site 573235005773 malonic semialdehyde reductase; Provisional; Region: PRK10538 573235005774 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 573235005775 putative NAD(P) binding site [chemical binding]; other site 573235005776 homodimer interface [polypeptide binding]; other site 573235005777 homotetramer interface [polypeptide binding]; other site 573235005778 active site 573235005779 Transcriptional regulators [Transcription]; Region: GntR; COG1802 573235005780 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573235005781 DNA-binding site [nucleotide binding]; DNA binding site 573235005782 FCD domain; Region: FCD; pfam07729 573235005783 putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318 573235005784 predicted mannonate dehydrogenase, C-terminal part 573235005785 predicted mannonate dehydrogenase, N-terminal part 573235005786 predicted transporter 573235005787 Prophage ECO26_P10, lambda-like phage 573235005788 multiple promoter invertase; Provisional; Region: mpi; PRK13413 573235005789 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 573235005790 catalytic residues [active] 573235005791 catalytic nucleophile [active] 573235005792 Presynaptic Site I dimer interface [polypeptide binding]; other site 573235005793 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 573235005794 Synaptic Flat tetramer interface [polypeptide binding]; other site 573235005795 Synaptic Site I dimer interface [polypeptide binding]; other site 573235005796 DNA binding site [nucleotide binding] 573235005797 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 573235005798 DNA-binding interface [nucleotide binding]; DNA binding site 573235005799 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 573235005800 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 573235005801 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 573235005802 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 573235005803 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 573235005804 Phage Tail Collar Domain; Region: Collar; pfam07484 573235005805 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 573235005806 Phage-related protein, tail component [Function unknown]; Region: COG4733 573235005807 Putative phage tail protein; Region: Phage-tail_3; pfam13550 573235005808 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 573235005809 Fibronectin type III protein; Region: DUF3672; pfam12421 573235005810 Phage-related protein, tail component [Function unknown]; Region: COG4723 573235005811 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 573235005812 MPN+ (JAMM) motif; other site 573235005813 Zinc-binding site [ion binding]; other site 573235005814 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 573235005815 NlpC/P60 family; Region: NLPC_P60; cl17555 573235005816 Phage-related protein [Function unknown]; Region: gp18; COG4672 573235005817 Phage-related protein [Function unknown]; Region: COG4718 573235005818 Phage-related minor tail protein [Function unknown]; Region: COG5281 573235005819 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 573235005820 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 573235005821 Minor tail protein T; Region: Phage_tail_T; pfam06223 573235005822 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; cl06106 573235005823 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 573235005824 Bacterial Ig-like domain 2; Region: BID_2; smart00635 573235005825 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 573235005826 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 573235005827 ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; pfam13856 573235005828 Uncharacterized conserved protein [Function unknown]; Region: COG5471 573235005829 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 573235005830 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 573235005831 oligomer interface [polypeptide binding]; other site 573235005832 active site residues [active] 573235005833 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 573235005834 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 573235005835 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 573235005836 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 573235005837 Protein of unknown function (DUF1441); Region: DUF1441; pfam07278 573235005838 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 573235005839 GnsA/GnsB family; Region: GnsAB; pfam08178 573235005840 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 573235005841 DNA-binding site [nucleotide binding]; DNA binding site 573235005842 RNA-binding motif; other site 573235005843 Protein of unknown function (DUF2514); Region: DUF2514; pfam10721 573235005844 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 573235005845 catalytic residues [active] 573235005846 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 573235005847 Lysis protein S; Region: Lysis_S; pfam04971 573235005848 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 573235005849 DNA-binding site [nucleotide binding]; DNA binding site 573235005850 RNA-binding motif; other site 573235005851 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 573235005852 DNA-binding site [nucleotide binding]; DNA binding site 573235005853 RNA-binding motif; other site 573235005854 Antitermination protein; Region: Antiterm; pfam03589 573235005855 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 573235005856 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 573235005857 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 573235005858 Protein of unknown function (DUF968); Region: DUF968; pfam06147 573235005859 Hok/gef family; Region: HOK_GEF; pfam01848 573235005860 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 573235005861 bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235 573235005862 Integrase core domain; Region: rve; pfam00665 573235005863 Integrase core domain; Region: rve_3; cl15866 573235005864 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 573235005865 primosomal protein DnaI; Provisional; Region: PRK02854 573235005866 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 573235005867 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 573235005868 transcriptional repressor DicA; Reviewed; Region: PRK09706 573235005869 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573235005870 non-specific DNA binding site [nucleotide binding]; other site 573235005871 salt bridge; other site 573235005872 sequence-specific DNA binding site [nucleotide binding]; other site 573235005873 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 573235005874 DicB protein; Region: DicB; pfam05358 573235005875 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 573235005876 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 573235005877 active site 573235005878 catalytic site [active] 573235005879 substrate binding site [chemical binding]; other site 573235005880 Prophage ECO26_P10; predicted excisionase, N-terminal fragment 573235005881 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 573235005882 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 573235005883 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573235005884 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 573235005885 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 573235005886 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 573235005887 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573235005888 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 573235005889 Transposase; Region: HTH_Tnp_1; pfam01527 573235005890 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 573235005891 Prophage ECO26_P10; predicted excisionase, C-terminal part 573235005892 Prophage ECO26_P10; predicted integrase, N-terminal part 573235005893 Prophage ECO26_P10; predicted transposase OrfB protein of insertion sequence IS600, C-terminal fragment 573235005894 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 573235005895 Transposase; Region: HTH_Tnp_1; pfam01527 573235005896 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 573235005897 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 573235005898 DNA binding site [nucleotide binding] 573235005899 active site 573235005900 Int/Topo IB signature motif; other site 573235005901 Prophage ECO26_P11, lambda-like phage 573235005902 DinI-like family; Region: DinI; pfam06183 573235005903 Prophage ECO26_P11; predicted ferredoxin, N-terminal part 573235005904 NFkB-p65-degrading zinc protease; Region: Peptidase_M85; pfam13678 573235005905 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 573235005906 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 573235005907 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 573235005908 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 573235005909 Phage-related protein, tail component [Function unknown]; Region: COG4733 573235005910 Putative phage tail protein; Region: Phage-tail_3; pfam13550 573235005911 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 573235005912 Interdomain contacts; other site 573235005913 Cytokine receptor motif; other site 573235005914 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 573235005915 Fibronectin type III protein; Region: DUF3672; pfam12421 573235005916 Phage-related protein, tail component [Function unknown]; Region: COG4723 573235005917 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 573235005918 MPN+ (JAMM) motif; other site 573235005919 Zinc-binding site [ion binding]; other site 573235005920 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 573235005921 NlpC/P60 family; Region: NLPC_P60; cl17555 573235005922 Phage-related protein [Function unknown]; Region: gp18; COG4672 573235005923 Phage-related protein [Function unknown]; Region: COG4718 573235005924 Phage-related minor tail protein [Function unknown]; Region: COG5281 573235005925 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 573235005926 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 573235005927 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 573235005928 Minor tail protein T; Region: Phage_tail_T; cl05636 573235005929 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894 573235005930 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 573235005931 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 573235005932 Prophage ECO26_P11; predicted minor tail protein, C-terminal part 573235005933 Prophage ECO26_P11; predicted minor tail protein, N-terminal part 573235005934 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 573235005935 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 573235005936 DNA packaging protein FI; Region: Packaging_FI; pfam14000 573235005937 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 573235005938 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 573235005939 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 573235005940 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 573235005941 tandem repeat interface [polypeptide binding]; other site 573235005942 oligomer interface [polypeptide binding]; other site 573235005943 active site residues [active] 573235005944 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 573235005945 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 573235005946 gpW; Region: gpW; pfam02831 573235005947 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 573235005948 Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471 573235005949 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 573235005950 PerC transcriptional activator; Region: PerC; pfam06069 573235005951 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 573235005952 Lipoprotein Rz1 precursor; Region: Rz1; pfam06085 573235005953 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 573235005954 catalytic residues [active] 573235005955 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 573235005956 Lysis protein S; Region: Lysis_S; pfam04971 573235005957 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 573235005958 Domain of unknown function (DUF303); Region: DUF303; pfam03629 573235005959 Protein of unknown function (DUF3927); Region: DUF3927; pfam13064 573235005960 tellurite resistance protein terB; Region: terB; cd07176 573235005961 putative metal binding site [ion binding]; other site 573235005962 Antitermination protein; Region: Antiterm; pfam03589 573235005963 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 573235005964 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 573235005965 Zn binding sites [ion binding]; other site 573235005966 Antitermination protein; Region: Antiterm; pfam03589 573235005967 Protein of unknown function (DUF968); Region: DUF968; pfam06147 573235005968 Protein of unknown function (DUF1044); Region: DUF1044; pfam06296 573235005969 Predicted transcriptional regulator [Transcription]; Region: COG2944 573235005970 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573235005971 non-specific DNA binding site [nucleotide binding]; other site 573235005972 salt bridge; other site 573235005973 sequence-specific DNA binding site [nucleotide binding]; other site 573235005974 Hok/gef family; Region: HOK_GEF; pfam01848 573235005975 ORF6N domain; Region: ORF6N; pfam10543 573235005976 Protein of unknown function (DUF1627); Region: DUF1627; pfam07789 573235005977 putative replication protein; Provisional; Region: PRK12377 573235005978 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573235005979 Walker A motif; other site 573235005980 ATP binding site [chemical binding]; other site 573235005981 Walker B motif; other site 573235005982 arginine finger; other site 573235005983 primosomal protein DnaI; Provisional; Region: PRK02854 573235005984 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 573235005985 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 573235005986 transcriptional repressor DicA; Reviewed; Region: PRK09706 573235005987 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573235005988 non-specific DNA binding site [nucleotide binding]; other site 573235005989 salt bridge; other site 573235005990 sequence-specific DNA binding site [nucleotide binding]; other site 573235005991 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 573235005992 DicB protein; Region: DicB; pfam05358 573235005993 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 573235005994 exonuclease VIII; Reviewed; Region: PRK09709 573235005995 Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630 573235005996 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 573235005997 active site 573235005998 substrate binding site [chemical binding]; other site 573235005999 catalytic site [active] 573235006000 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 573235006001 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 573235006002 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 573235006003 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 573235006004 Int/Topo IB signature motif; other site 573235006005 putative oxidoreductase; Provisional; Region: PRK10083 573235006006 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 573235006007 putative NAD(P) binding site [chemical binding]; other site 573235006008 catalytic Zn binding site [ion binding]; other site 573235006009 structural Zn binding site [ion binding]; other site 573235006010 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 573235006011 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 573235006012 putative active site pocket [active] 573235006013 putative metal binding site [ion binding]; other site 573235006014 hypothetical protein; Provisional; Region: PRK02237 573235006015 hypothetical protein; Provisional; Region: PRK13659 573235006016 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 573235006017 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573235006018 Coenzyme A binding pocket [chemical binding]; other site 573235006019 Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788 573235006020 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 573235006021 oxidoreductase subunit, N-terminal part 573235006022 oxidoreductase subunit, C-terminal part 573235006023 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 573235006024 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 573235006025 putative [Fe4-S4] binding site [ion binding]; other site 573235006026 putative molybdopterin cofactor binding site [chemical binding]; other site 573235006027 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 573235006028 putative molybdopterin cofactor binding site; other site 573235006029 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 573235006030 4Fe-4S binding domain; Region: Fer4; cl02805 573235006031 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 573235006032 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 573235006033 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 573235006034 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 573235006035 Cl- selectivity filter; other site 573235006036 Cl- binding residues [ion binding]; other site 573235006037 pore gating glutamate residue; other site 573235006038 dimer interface [polypeptide binding]; other site 573235006039 putative dithiobiotin synthetase; Provisional; Region: PRK12374 573235006040 AAA domain; Region: AAA_26; pfam13500 573235006041 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 573235006042 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 573235006043 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 573235006044 nucleotide binding site [chemical binding]; other site 573235006045 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 573235006046 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573235006047 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 573235006048 dimerization interface [polypeptide binding]; other site 573235006049 substrate binding pocket [chemical binding]; other site 573235006050 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 573235006051 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235006052 putative substrate translocation pore; other site 573235006053 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 573235006054 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 573235006055 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 573235006056 predicted inner membrane protein, N-terminal part 573235006057 Prophage ECO26_P12, untypable 573235006058 Phage Terminase; Region: Terminase_1; pfam03354 573235006059 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: COG3747 573235006060 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 573235006061 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 573235006062 active site 573235006063 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 573235006064 oligomerization interface [polypeptide binding]; other site 573235006065 Bacteriophage head-tail adaptor [General function prediction only]; Region: COG5614 573235006066 Phage-related protein [Function unknown]; Region: COG4695 573235006067 Phage portal protein; Region: Phage_portal; pfam04860 573235006068 Phage head maturation protease [General function prediction only]; Region: COG3740 573235006069 Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653 573235006070 Phage capsid family; Region: Phage_capsid; pfam05065 573235006071 PerC transcriptional activator; Region: PerC; pfam06069 573235006072 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 573235006073 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 573235006074 ssDNA binding site [nucleotide binding]; other site 573235006075 dimer interface [polypeptide binding]; other site 573235006076 tetramer (dimer of dimers) interface [polypeptide binding]; other site 573235006077 D5 N terminal like; Region: D5_N; smart00885 573235006078 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 573235006079 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 573235006080 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 573235006081 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 573235006082 integrase; Provisional; Region: PRK09692 573235006083 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 573235006084 active site 573235006085 Int/Topo IB signature motif; other site 573235006086 predicted inner membrane protein, C-terminal part 573235006087 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 573235006088 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 573235006089 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 573235006090 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 573235006091 ligand binding site [chemical binding]; other site 573235006092 homodimer interface [polypeptide binding]; other site 573235006093 NAD(P) binding site [chemical binding]; other site 573235006094 trimer interface B [polypeptide binding]; other site 573235006095 trimer interface A [polypeptide binding]; other site 573235006096 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 573235006097 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 573235006098 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 573235006099 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 573235006100 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 573235006101 Spore germination protein; Region: Spore_permease; cl17796 573235006102 dihydromonapterin reductase; Provisional; Region: PRK06483 573235006103 pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357 573235006104 NADP binding site [chemical binding]; other site 573235006105 substrate binding pocket [chemical binding]; other site 573235006106 active site 573235006107 GlpM protein; Region: GlpM; pfam06942 573235006108 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 573235006109 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573235006110 active site 573235006111 phosphorylation site [posttranslational modification] 573235006112 intermolecular recognition site; other site 573235006113 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573235006114 DNA binding site [nucleotide binding] 573235006115 sensor protein RstB; Provisional; Region: PRK10604 573235006116 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573235006117 dimerization interface [polypeptide binding]; other site 573235006118 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573235006119 dimer interface [polypeptide binding]; other site 573235006120 phosphorylation site [posttranslational modification] 573235006121 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573235006122 ATP binding site [chemical binding]; other site 573235006123 Mg2+ binding site [ion binding]; other site 573235006124 G-X-G motif; other site 573235006125 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 573235006126 fumarate hydratase; Reviewed; Region: fumC; PRK00485 573235006127 Class II fumarases; Region: Fumarase_classII; cd01362 573235006128 active site 573235006129 tetramer interface [polypeptide binding]; other site 573235006130 fumarate hydratase; Provisional; Region: PRK15389 573235006131 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 573235006132 Fumarase C-terminus; Region: Fumerase_C; pfam05683 573235006133 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 573235006134 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 573235006135 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 573235006136 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 573235006137 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 573235006138 putative outer membrane porin protein; Provisional; Region: PRK11379 573235006139 glucuronide transporter; Provisional; Region: PRK09848 573235006140 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 573235006141 beta-D-glucuronidase; Provisional; Region: PRK10150 573235006142 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 573235006143 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 573235006144 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 573235006145 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573235006146 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573235006147 7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113 573235006148 7 alpha-hydroxysteroid dehydrogenase (7 alpha-HSDH), classical (c) SDRs; Region: 7_alpha_HSDH_SDR_c; cd05365 573235006149 NAD binding site [chemical binding]; other site 573235006150 substrate binding site [chemical binding]; other site 573235006151 homotetramer interface [polypeptide binding]; other site 573235006152 homodimer interface [polypeptide binding]; other site 573235006153 active site 573235006154 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 573235006155 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573235006156 DNA binding site [nucleotide binding] 573235006157 domain linker motif; other site 573235006158 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 573235006159 putative dimerization interface [polypeptide binding]; other site 573235006160 putative ligand binding site [chemical binding]; other site 573235006161 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 573235006162 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 573235006163 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 573235006164 active site turn [active] 573235006165 phosphorylation site [posttranslational modification] 573235006166 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 573235006167 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573235006168 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573235006169 homodimer interface [polypeptide binding]; other site 573235006170 catalytic residue [active] 573235006171 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 573235006172 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 573235006173 active site 573235006174 purine riboside binding site [chemical binding]; other site 573235006175 putative oxidoreductase; Provisional; Region: PRK11579 573235006176 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 573235006177 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 573235006178 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 573235006179 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 573235006180 electron transport complex protein RsxA; Provisional; Region: PRK05151 573235006181 electron transport complex protein RnfB; Provisional; Region: PRK05113 573235006182 Putative Fe-S cluster; Region: FeS; pfam04060 573235006183 4Fe-4S binding domain; Region: Fer4; pfam00037 573235006184 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 573235006185 SLBB domain; Region: SLBB; pfam10531 573235006186 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 573235006187 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 573235006188 electron transport complex protein RnfG; Validated; Region: PRK01908 573235006189 electron transport complex RsxE subunit; Provisional; Region: PRK12405 573235006190 endonuclease III; Provisional; Region: PRK10702 573235006191 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 573235006192 minor groove reading motif; other site 573235006193 helix-hairpin-helix signature motif; other site 573235006194 substrate binding pocket [chemical binding]; other site 573235006195 active site 573235006196 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 573235006197 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 573235006198 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235006199 putative substrate translocation pore; other site 573235006200 POT family; Region: PTR2; pfam00854 573235006201 glutathionine S-transferase; Provisional; Region: PRK10542 573235006202 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 573235006203 C-terminal domain interface [polypeptide binding]; other site 573235006204 GSH binding site (G-site) [chemical binding]; other site 573235006205 dimer interface [polypeptide binding]; other site 573235006206 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 573235006207 N-terminal domain interface [polypeptide binding]; other site 573235006208 dimer interface [polypeptide binding]; other site 573235006209 substrate binding pocket (H-site) [chemical binding]; other site 573235006210 pyridoxamine kinase; Validated; Region: PRK05756 573235006211 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 573235006212 dimer interface [polypeptide binding]; other site 573235006213 pyridoxal binding site [chemical binding]; other site 573235006214 ATP binding site [chemical binding]; other site 573235006215 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 573235006216 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 573235006217 active site 573235006218 HIGH motif; other site 573235006219 dimer interface [polypeptide binding]; other site 573235006220 KMSKS motif; other site 573235006221 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 573235006222 RNA binding surface [nucleotide binding]; other site 573235006223 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 573235006224 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 573235006225 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 573235006226 lysozyme inhibitor; Provisional; Region: PRK11372 573235006227 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 573235006228 Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702 573235006229 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 573235006230 transcriptional regulator SlyA; Provisional; Region: PRK03573 573235006231 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 573235006232 Protein of unknown function (DUF1656); Region: DUF1656; cl11658 573235006233 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 573235006234 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 573235006235 HlyD family secretion protein; Region: HlyD_3; pfam13437 573235006236 Fusaric acid resistance protein family; Region: FUSC; pfam04632 573235006237 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 573235006238 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 573235006239 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 573235006240 E-class dimer interface [polypeptide binding]; other site 573235006241 P-class dimer interface [polypeptide binding]; other site 573235006242 active site 573235006243 Cu2+ binding site [ion binding]; other site 573235006244 Zn2+ binding site [ion binding]; other site 573235006245 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 573235006246 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 573235006247 active site 573235006248 catalytic tetrad [active] 573235006249 Predicted Fe-S protein [General function prediction only]; Region: COG3313 573235006250 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573235006251 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573235006252 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 573235006253 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 573235006254 FMN binding site [chemical binding]; other site 573235006255 active site 573235006256 substrate binding site [chemical binding]; other site 573235006257 catalytic residue [active] 573235006258 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 573235006259 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 573235006260 dimer interface [polypeptide binding]; other site 573235006261 active site 573235006262 metal binding site [ion binding]; metal-binding site 573235006263 glutathione binding site [chemical binding]; other site 573235006264 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 573235006265 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 573235006266 dimer interface [polypeptide binding]; other site 573235006267 catalytic site [active] 573235006268 putative active site [active] 573235006269 putative substrate binding site [chemical binding]; other site 573235006270 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573235006271 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 573235006272 ATP binding site [chemical binding]; other site 573235006273 putative Mg++ binding site [ion binding]; other site 573235006274 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573235006275 nucleotide binding region [chemical binding]; other site 573235006276 ATP-binding site [chemical binding]; other site 573235006277 DEAD/H associated; Region: DEAD_assoc; pfam08494 573235006278 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 573235006279 putative GSH binding site [chemical binding]; other site 573235006280 catalytic residues [active] 573235006281 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 573235006282 NlpC/P60 family; Region: NLPC_P60; pfam00877 573235006283 superoxide dismutase; Provisional; Region: PRK10543 573235006284 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 573235006285 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 573235006286 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235006287 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573235006288 putative substrate translocation pore; other site 573235006289 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 573235006290 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573235006291 DNA binding site [nucleotide binding] 573235006292 domain linker motif; other site 573235006293 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 573235006294 dimerization interface [polypeptide binding]; other site 573235006295 ligand binding site [chemical binding]; other site 573235006296 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 573235006297 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573235006298 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 573235006299 dimerization interface [polypeptide binding]; other site 573235006300 putative transporter; Provisional; Region: PRK11043 573235006301 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235006302 putative substrate translocation pore; other site 573235006303 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 573235006304 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 573235006305 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573235006306 S-adenosylmethionine binding site [chemical binding]; other site 573235006307 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 573235006308 Lumazine binding domain; Region: Lum_binding; pfam00677 573235006309 Lumazine binding domain; Region: Lum_binding; pfam00677 573235006310 multidrug efflux protein; Reviewed; Region: PRK01766 573235006311 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 573235006312 cation binding site [ion binding]; other site 573235006313 hypothetical protein; Provisional; Region: PRK09945 573235006314 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 573235006315 putative monooxygenase; Provisional; Region: PRK11118 573235006316 hypothetical protein; Provisional; Region: PRK09897 573235006317 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 573235006318 hypothetical protein; Provisional; Region: PRK09946 573235006319 thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006 573235006320 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 573235006321 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 573235006322 hypothetical protein; Provisional; Region: PRK09947 573235006323 putative oxidoreductase; Provisional; Region: PRK09849 573235006324 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 573235006325 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 573235006326 hypothetical protein; Provisional; Region: PRK09898 573235006327 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 573235006328 hypothetical protein; Provisional; Region: PRK10292 573235006329 pyruvate kinase; Provisional; Region: PRK09206 573235006330 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 573235006331 domain interfaces; other site 573235006332 active site 573235006333 murein lipoprotein; Provisional; Region: PRK15396 573235006334 L,D-transpeptidase; Provisional; Region: PRK10190 573235006335 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 573235006336 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 573235006337 cysteine desufuration protein SufE; Provisional; Region: PRK09296 573235006338 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 573235006339 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 573235006340 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 573235006341 catalytic residue [active] 573235006342 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 573235006343 FeS assembly protein SufD; Region: sufD; TIGR01981 573235006344 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 573235006345 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 573235006346 Walker A/P-loop; other site 573235006347 ATP binding site [chemical binding]; other site 573235006348 Q-loop/lid; other site 573235006349 ABC transporter signature motif; other site 573235006350 Walker B; other site 573235006351 D-loop; other site 573235006352 H-loop/switch region; other site 573235006353 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 573235006354 putative ABC transporter; Region: ycf24; CHL00085 573235006355 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 573235006356 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 573235006357 CoenzymeA binding site [chemical binding]; other site 573235006358 subunit interaction site [polypeptide binding]; other site 573235006359 PHB binding site; other site 573235006360 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 573235006361 FAD binding domain; Region: FAD_binding_4; pfam01565 573235006362 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 573235006363 putative inner membrane protein; Provisional; Region: PRK10983 573235006364 Domain of unknown function DUF20; Region: UPF0118; pfam01594 573235006365 Domain of unknown function (DUF1870); Region: DUF1870; pfam08965 573235006366 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235006367 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573235006368 putative substrate translocation pore; other site 573235006369 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235006370 putative substrate translocation pore; other site 573235006371 quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749 573235006372 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 573235006373 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 573235006374 shikimate binding site; other site 573235006375 NAD(P) binding site [chemical binding]; other site 573235006376 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 573235006377 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 573235006378 active site 573235006379 catalytic residue [active] 573235006380 dimer interface [polypeptide binding]; other site 573235006381 fused predicted acetyl-CoA:acetoacetyl-CoA transferase: alpha subunit/beta subunit, N-terminal part 573235006382 fused predicted acetyl-CoA:acetoacetyl-CoA transferase: alpha subunit/beta subunit, C-terminal part 573235006383 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 573235006384 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 573235006385 active site 573235006386 Cupin domain; Region: Cupin_2; pfam07883 573235006387 Winged helix DNA-binding domain (DUF1495); Region: DUF1495; cl01336 573235006388 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 573235006389 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573235006390 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 573235006391 Ligand binding site [chemical binding]; other site 573235006392 Electron transfer flavoprotein domain; Region: ETF; pfam01012 573235006393 electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916 573235006394 Electron transfer flavoprotein domain; Region: ETF; smart00893 573235006395 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 573235006396 oxidoreductase; Provisional; Region: PRK10015 573235006397 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 573235006398 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 573235006399 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 573235006400 acyl-activating enzyme (AAE) consensus motif; other site 573235006401 putative AMP binding site [chemical binding]; other site 573235006402 putative active site [active] 573235006403 putative CoA binding site [chemical binding]; other site 573235006404 phosphoenolpyruvate synthase; Validated; Region: PRK06464 573235006405 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 573235006406 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 573235006407 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 573235006408 PEP synthetase regulatory protein; Provisional; Region: PRK05339 573235006409 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 573235006410 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 573235006411 Hemin uptake protein [Inorganic ion transport and metabolism]; Region: HemP; COG4256 573235006412 Uncharacterized conserved protein [Function unknown]; Region: COG0397 573235006413 hypothetical protein; Validated; Region: PRK00029 573235006414 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 573235006415 NlpC/P60 family; Region: NLPC_P60; pfam00877 573235006416 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 573235006417 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 573235006418 Walker A/P-loop; other site 573235006419 ATP binding site [chemical binding]; other site 573235006420 Q-loop/lid; other site 573235006421 ABC transporter signature motif; other site 573235006422 Walker B; other site 573235006423 D-loop; other site 573235006424 H-loop/switch region; other site 573235006425 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 573235006426 catalytic residues [active] 573235006427 dimer interface [polypeptide binding]; other site 573235006428 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 573235006429 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 573235006430 ABC-ATPase subunit interface; other site 573235006431 dimer interface [polypeptide binding]; other site 573235006432 putative PBP binding regions; other site 573235006433 Prophage ECO26_P13, P2-like phage 573235006434 integrase; Provisional; Region: int; PHA02601 573235006435 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 573235006436 active site 573235006437 DNA binding site [nucleotide binding] 573235006438 Int/Topo IB signature motif; other site 573235006439 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573235006440 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 573235006441 non-specific DNA binding site [nucleotide binding]; other site 573235006442 salt bridge; other site 573235006443 sequence-specific DNA binding site [nucleotide binding]; other site 573235006444 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 573235006445 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 573235006446 Mg binding site [ion binding]; other site 573235006447 nucleotide binding site [chemical binding]; other site 573235006448 putative protofilament interface [polypeptide binding]; other site 573235006449 Plasmid stability protein; Region: Plasmid_stab_B; pfam10784 573235006450 Phage-related protein [Function unknown]; Region: COG4695; cl01923 573235006451 Phage portal protein; Region: Phage_portal; pfam04860 573235006452 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 573235006453 terminase ATPase subunit; Provisional; Region: P; PHA02535 573235006454 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 573235006455 Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947 573235006456 terminase endonuclease subunit; Provisional; Region: M; PHA02537 573235006457 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 573235006458 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 573235006459 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 573235006460 Phage holin family (Lysis protein S); Region: Phage_holin_3; cl04938 573235006461 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 573235006462 Protein of unknown function (DUF2570); Region: DUF2570; pfam10828 573235006463 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 573235006464 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 573235006465 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 573235006466 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 573235006467 Baseplate J-like protein; Region: Baseplate_J; cl01294 573235006468 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 573235006469 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 573235006470 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 573235006471 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 573235006472 Phage Tail Collar Domain; Region: Collar; pfam07484 573235006473 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 573235006474 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 573235006475 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 573235006476 trimer interface [polypeptide binding]; other site 573235006477 active site 573235006478 substrate binding site [chemical binding]; other site 573235006479 CoA binding site [chemical binding]; other site 573235006480 Phage protein U [General function prediction only]; Region: COG3499 573235006481 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 573235006482 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 573235006483 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 573235006484 Phage tail tube protein FII; Region: Phage_tube; cl01390 573235006485 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 573235006486 tail protein; Provisional; Region: D; PHA02561 573235006487 His-Xaa-Ser repeat protein HxsA; Region: His_Ser_Rich; TIGR03979 573235006488 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 573235006489 His-Xaa-Ser system radical SAM maturase HxsC; Region: rSAM_pair_HxsC; TIGR03977 573235006490 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573235006491 FeS/SAM binding site; other site 573235006492 His-Xaa-Ser system radical SAM maturase HxsB; Region: rSAM_paired_1; TIGR03978 573235006493 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573235006494 FeS/SAM binding site; other site 573235006495 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 573235006496 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 573235006497 IHF dimer interface [polypeptide binding]; other site 573235006498 IHF - DNA interface [nucleotide binding]; other site 573235006499 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 573235006500 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 573235006501 putative tRNA-binding site [nucleotide binding]; other site 573235006502 B3/4 domain; Region: B3_4; pfam03483 573235006503 tRNA synthetase B5 domain; Region: B5; smart00874 573235006504 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 573235006505 dimer interface [polypeptide binding]; other site 573235006506 motif 1; other site 573235006507 motif 3; other site 573235006508 motif 2; other site 573235006509 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 573235006510 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 573235006511 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 573235006512 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 573235006513 dimer interface [polypeptide binding]; other site 573235006514 motif 1; other site 573235006515 active site 573235006516 motif 2; other site 573235006517 motif 3; other site 573235006518 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 573235006519 23S rRNA binding site [nucleotide binding]; other site 573235006520 L21 binding site [polypeptide binding]; other site 573235006521 L13 binding site [polypeptide binding]; other site 573235006522 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 573235006523 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 573235006524 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 573235006525 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 573235006526 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 573235006527 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 573235006528 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 573235006529 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 573235006530 active site 573235006531 dimer interface [polypeptide binding]; other site 573235006532 motif 1; other site 573235006533 motif 2; other site 573235006534 motif 3; other site 573235006535 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 573235006536 anticodon binding site; other site 573235006537 T3SS effector EspL, N-terminal part 573235006538 T3SS effector EspL, C-terminal part 573235006539 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 573235006540 6-phosphofructokinase 2; Provisional; Region: PRK10294 573235006541 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 573235006542 putative substrate binding site [chemical binding]; other site 573235006543 putative ATP binding site [chemical binding]; other site 573235006544 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 573235006545 Phosphotransferase enzyme family; Region: APH; pfam01636 573235006546 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 573235006547 active site 573235006548 ATP binding site [chemical binding]; other site 573235006549 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 573235006550 YniB-like protein; Region: YniB; pfam14002 573235006551 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 573235006552 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 573235006553 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573235006554 motif II; other site 573235006555 inner membrane protein; Provisional; Region: PRK11648 573235006556 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 573235006557 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 573235006558 conserved predicted protein, C-terminal part 573235006559 conserved predicted protein, N-terminal part 573235006560 cell division modulator; Provisional; Region: PRK10113 573235006561 hydroperoxidase II; Provisional; Region: katE; PRK11249 573235006562 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 573235006563 tetramer interface [polypeptide binding]; other site 573235006564 heme binding pocket [chemical binding]; other site 573235006565 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 573235006566 domain interactions; other site 573235006567 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 573235006568 Transposase; Region: DEDD_Tnp_IS110; pfam01548 573235006569 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 573235006570 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 573235006571 putative active site [active] 573235006572 YdjC motif; other site 573235006573 Mg binding site [ion binding]; other site 573235006574 putative homodimer interface [polypeptide binding]; other site 573235006575 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 573235006576 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 573235006577 NAD binding site [chemical binding]; other site 573235006578 sugar binding site [chemical binding]; other site 573235006579 divalent metal binding site [ion binding]; other site 573235006580 tetramer (dimer of dimers) interface [polypeptide binding]; other site 573235006581 dimer interface [polypeptide binding]; other site 573235006582 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 573235006583 Cupin domain; Region: Cupin_2; pfam07883 573235006584 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573235006585 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 573235006586 methionine cluster; other site 573235006587 active site 573235006588 phosphorylation site [posttranslational modification] 573235006589 metal binding site [ion binding]; metal-binding site 573235006590 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 573235006591 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 573235006592 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 573235006593 active site 573235006594 P-loop; other site 573235006595 phosphorylation site [posttranslational modification] 573235006596 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 573235006597 NAD+ synthetase; Region: nadE; TIGR00552 573235006598 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 573235006599 homodimer interface [polypeptide binding]; other site 573235006600 NAD binding pocket [chemical binding]; other site 573235006601 ATP binding pocket [chemical binding]; other site 573235006602 Mg binding site [ion binding]; other site 573235006603 active-site loop [active] 573235006604 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 573235006605 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 573235006606 GIY-YIG motif/motif A; other site 573235006607 active site 573235006608 catalytic site [active] 573235006609 putative DNA binding site [nucleotide binding]; other site 573235006610 metal binding site [ion binding]; metal-binding site 573235006611 hypothetical protein; Provisional; Region: PRK11396 573235006612 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 573235006613 dimer interface [polypeptide binding]; other site 573235006614 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 573235006615 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 573235006616 putative active site [active] 573235006617 Zn binding site [ion binding]; other site 573235006618 succinylarginine dihydrolase; Provisional; Region: PRK13281 573235006619 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 573235006620 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 573235006621 NAD(P) binding site [chemical binding]; other site 573235006622 catalytic residues [active] 573235006623 arginine succinyltransferase; Provisional; Region: PRK10456 573235006624 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 573235006625 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 573235006626 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 573235006627 inhibitor-cofactor binding pocket; inhibition site 573235006628 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573235006629 catalytic residue [active] 573235006630 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 573235006631 putative catalytic site [active] 573235006632 putative phosphate binding site [ion binding]; other site 573235006633 active site 573235006634 metal binding site A [ion binding]; metal-binding site 573235006635 DNA binding site [nucleotide binding] 573235006636 putative AP binding site [nucleotide binding]; other site 573235006637 putative metal binding site B [ion binding]; other site 573235006638 Uncharacterized conserved protein [Function unknown]; Region: COG0398 573235006639 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 573235006640 Uncharacterized conserved protein [Function unknown]; Region: COG0398 573235006641 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 573235006642 Uncharacterized conserved protein [Function unknown]; Region: COG2128 573235006643 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 573235006644 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 573235006645 hypothetical protein; Provisional; Region: PRK11622 573235006646 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135 573235006647 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573235006648 dimer interface [polypeptide binding]; other site 573235006649 conserved gate region; other site 573235006650 putative PBP binding loops; other site 573235006651 ABC-ATPase subunit interface; other site 573235006652 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 573235006653 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573235006654 Walker A/P-loop; other site 573235006655 ATP binding site [chemical binding]; other site 573235006656 Q-loop/lid; other site 573235006657 ABC transporter signature motif; other site 573235006658 Walker B; other site 573235006659 D-loop; other site 573235006660 H-loop/switch region; other site 573235006661 Rhodanese Homology Domain; Region: RHOD; smart00450 573235006662 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 573235006663 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 573235006664 active site residue [active] 573235006665 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 573235006666 active site residue [active] 573235006667 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 573235006668 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 573235006669 active site 573235006670 8-oxo-dGMP binding site [chemical binding]; other site 573235006671 nudix motif; other site 573235006672 metal binding site [ion binding]; metal-binding site 573235006673 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 573235006674 glutamate dehydrogenase; Provisional; Region: PRK09414 573235006675 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 573235006676 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 573235006677 NAD(P) binding site [chemical binding]; other site 573235006678 hypothetical protein; Provisional; Region: PRK11380 573235006679 DNA topoisomerase III; Provisional; Region: PRK07726 573235006680 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 573235006681 active site 573235006682 putative interdomain interaction site [polypeptide binding]; other site 573235006683 putative metal-binding site [ion binding]; other site 573235006684 putative nucleotide binding site [chemical binding]; other site 573235006685 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 573235006686 domain I; other site 573235006687 DNA binding groove [nucleotide binding] 573235006688 phosphate binding site [ion binding]; other site 573235006689 domain II; other site 573235006690 domain III; other site 573235006691 nucleotide binding site [chemical binding]; other site 573235006692 catalytic site [active] 573235006693 domain IV; other site 573235006694 selenophosphate synthetase; Provisional; Region: PRK00943 573235006695 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 573235006696 dimerization interface [polypeptide binding]; other site 573235006697 putative ATP binding site [chemical binding]; other site 573235006698 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 573235006699 putative FMN binding site [chemical binding]; other site 573235006700 protease 4; Provisional; Region: PRK10949 573235006701 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 573235006702 tandem repeat interface [polypeptide binding]; other site 573235006703 oligomer interface [polypeptide binding]; other site 573235006704 active site residues [active] 573235006705 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 573235006706 tandem repeat interface [polypeptide binding]; other site 573235006707 oligomer interface [polypeptide binding]; other site 573235006708 active site residues [active] 573235006709 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 573235006710 active site 573235006711 homodimer interface [polypeptide binding]; other site 573235006712 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 573235006713 Isochorismatase family; Region: Isochorismatase; pfam00857 573235006714 catalytic triad [active] 573235006715 metal binding site [ion binding]; metal-binding site 573235006716 conserved cis-peptide bond; other site 573235006717 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 573235006718 methionine sulfoxide reductase B; Provisional; Region: PRK00222 573235006719 SelR domain; Region: SelR; pfam01641 573235006720 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 573235006721 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 573235006722 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 573235006723 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 573235006724 active site 573235006725 phosphate binding residues; other site 573235006726 catalytic residues [active] 573235006727 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 573235006728 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 573235006729 active site 573235006730 catalytic tetrad [active] 573235006731 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 573235006732 PrkA family serine protein kinase; Provisional; Region: PRK15455 573235006733 AAA ATPase domain; Region: AAA_16; pfam13191 573235006734 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 573235006735 hypothetical protein; Provisional; Region: PRK05325 573235006736 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 573235006737 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573235006738 metal binding site [ion binding]; metal-binding site 573235006739 active site 573235006740 I-site; other site 573235006741 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 573235006742 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573235006743 metal binding site [ion binding]; metal-binding site 573235006744 active site 573235006745 I-site; other site 573235006746 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 573235006747 putative deacylase active site [active] 573235006748 Predicted membrane protein [Function unknown]; Region: COG2707 573235006749 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 573235006750 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573235006751 cyanate transporter; Region: CynX; TIGR00896 573235006752 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235006753 putative substrate translocation pore; other site 573235006754 Uncharacterized conserved protein [Function unknown]; Region: COG3189 573235006755 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 573235006756 Domain of unknown function (DUF333); Region: DUF333; pfam03891 573235006757 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 573235006758 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 573235006759 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 573235006760 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573235006761 metal binding site [ion binding]; metal-binding site 573235006762 active site 573235006763 I-site; other site 573235006764 hypothetical protein; Provisional; Region: PRK10457 573235006765 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 573235006766 Probable transposase; Region: OrfB_IS605; pfam01385 573235006767 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 573235006768 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 573235006769 Transposase IS200 like; Region: Y1_Tnp; pfam01797 573235006770 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 573235006771 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 573235006772 leucine export protein LeuE; Provisional; Region: PRK10958 573235006773 transcriptional activator TtdR; Provisional; Region: PRK09801 573235006774 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573235006775 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 573235006776 putative effector binding pocket; other site 573235006777 putative dimerization interface [polypeptide binding]; other site 573235006778 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 573235006779 tartrate dehydrogenase; Region: TTC; TIGR02089 573235006780 putative transporter; Provisional; Region: PRK09950 573235006781 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 573235006782 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 573235006783 [2Fe-2S] cluster binding site [ion binding]; other site 573235006784 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_2; cd08886 573235006785 putative alpha subunit interface [polypeptide binding]; other site 573235006786 putative active site [active] 573235006787 putative substrate binding site [chemical binding]; other site 573235006788 Fe binding site [ion binding]; other site 573235006789 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 573235006790 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 573235006791 FMN-binding pocket [chemical binding]; other site 573235006792 flavin binding motif; other site 573235006793 phosphate binding motif [ion binding]; other site 573235006794 beta-alpha-beta structure motif; other site 573235006795 NAD binding pocket [chemical binding]; other site 573235006796 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 573235006797 catalytic loop [active] 573235006798 iron binding site [ion binding]; other site 573235006799 ribonuclease D; Provisional; Region: PRK10829 573235006800 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 573235006801 catalytic site [active] 573235006802 putative active site [active] 573235006803 putative substrate binding site [chemical binding]; other site 573235006804 Helicase and RNase D C-terminal; Region: HRDC; smart00341 573235006805 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 573235006806 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 573235006807 acyl-activating enzyme (AAE) consensus motif; other site 573235006808 putative AMP binding site [chemical binding]; other site 573235006809 putative active site [active] 573235006810 putative CoA binding site [chemical binding]; other site 573235006811 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 573235006812 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 573235006813 Glycoprotease family; Region: Peptidase_M22; pfam00814 573235006814 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 573235006815 DEAD/DEAH box helicase; Region: DEAD; pfam00270 573235006816 DEAD_2; Region: DEAD_2; pfam06733 573235006817 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 573235006818 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 573235006819 homotrimer interaction site [polypeptide binding]; other site 573235006820 putative active site [active] 573235006821 Domain of unknown function (DUF1889); Region: DUF1889; pfam08986 573235006822 hypothetical protein; Provisional; Region: PRK05114 573235006823 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 573235006824 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 573235006825 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 573235006826 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 573235006827 putative active site [active] 573235006828 putative CoA binding site [chemical binding]; other site 573235006829 nudix motif; other site 573235006830 metal binding site [ion binding]; metal-binding site 573235006831 L-serine deaminase; Provisional; Region: PRK15023 573235006832 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 573235006833 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 573235006834 phage resistance protein; Provisional; Region: PRK10551 573235006835 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 573235006836 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 573235006837 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 573235006838 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 573235006839 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 573235006840 Transporter associated domain; Region: CorC_HlyC; smart01091 573235006841 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 573235006842 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 573235006843 active pocket/dimerization site; other site 573235006844 active site 573235006845 phosphorylation site [posttranslational modification] 573235006846 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 573235006847 active site 573235006848 phosphorylation site [posttranslational modification] 573235006849 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 573235006850 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 573235006851 Predicted membrane protein [Function unknown]; Region: COG4811 573235006852 hypothetical protein; Provisional; Region: PRK11469 573235006853 Domain of unknown function DUF; Region: DUF204; pfam02659 573235006854 Domain of unknown function DUF; Region: DUF204; pfam02659 573235006855 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 573235006856 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573235006857 S-adenosylmethionine binding site [chemical binding]; other site 573235006858 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 573235006859 DNA-binding site [nucleotide binding]; DNA binding site 573235006860 RNA-binding motif; other site 573235006861 Protein of unknown function (DUF2627); Region: DUF2527; pfam10736 573235006862 YebO-like protein; Region: YebO; pfam13974 573235006863 PhoPQ regulatory protein; Provisional; Region: PRK10299 573235006864 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 573235006865 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573235006866 dimerization interface [polypeptide binding]; other site 573235006867 putative Zn2+ binding site [ion binding]; other site 573235006868 putative DNA binding site [nucleotide binding]; other site 573235006869 Bacterial transcriptional regulator; Region: IclR; pfam01614 573235006870 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235006871 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573235006872 putative substrate translocation pore; other site 573235006873 Predicted integral membrane protein [Function unknown]; Region: COG5521 573235006874 heat shock protein HtpX; Provisional; Region: PRK05457 573235006875 carboxy-terminal protease; Provisional; Region: PRK11186 573235006876 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 573235006877 protein binding site [polypeptide binding]; other site 573235006878 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 573235006879 Catalytic dyad [active] 573235006880 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 573235006881 ProP expression regulator; Provisional; Region: PRK04950 573235006882 ProQ/FINO family; Region: ProQ; pfam04352 573235006883 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 573235006884 GAF domain; Region: GAF_2; pfam13185 573235006885 integral membrane protein, PqiA family; Region: pqiA_fam; TIGR00155 573235006886 Paraquat-inducible protein A; Region: PqiA; pfam04403 573235006887 Paraquat-inducible protein A; Region: PqiA; pfam04403 573235006888 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 573235006889 mce related protein; Region: MCE; pfam02470 573235006890 mce related protein; Region: MCE; pfam02470 573235006891 mce related protein; Region: MCE; pfam02470 573235006892 mce related protein; Region: MCE; pfam02470 573235006893 mce related protein; Region: MCE; pfam02470 573235006894 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 573235006895 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573235006896 S-adenosylmethionine binding site [chemical binding]; other site 573235006897 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 573235006898 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 573235006899 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 573235006900 serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439 573235006901 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 573235006902 Prophage ECO26_P14, lambda-like phage 573235006903 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 573235006904 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 573235006905 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 573235006906 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 573235006907 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 573235006908 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 573235006909 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 573235006910 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573235006911 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 573235006912 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 573235006913 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 573235006914 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573235006915 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 573235006916 Transposase; Region: HTH_Tnp_1; pfam01527 573235006917 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 573235006918 Phage-related protein, tail component [Function unknown]; Region: COG4733 573235006919 Putative phage tail protein; Region: Phage-tail_3; pfam13550 573235006920 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 573235006921 Fibronectin type III protein; Region: DUF3672; pfam12421 573235006922 Phage-related protein, tail component [Function unknown]; Region: COG4723 573235006923 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 573235006924 MPN+ (JAMM) motif; other site 573235006925 Zinc-binding site [ion binding]; other site 573235006926 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 573235006927 NlpC/P60 family; Region: NLPC_P60; cl17555 573235006928 Phage-related protein [Function unknown]; Region: gp18; COG4672 573235006929 Phage-related protein [Function unknown]; Region: COG4718 573235006930 Phage-related minor tail protein [Function unknown]; Region: COG5281 573235006931 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 573235006932 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 573235006933 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 573235006934 Minor tail protein T; Region: Phage_tail_T; cl05636 573235006935 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894 573235006936 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 573235006937 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 573235006938 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 573235006939 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 573235006940 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 573235006941 DNA packaging protein FI; Region: Packaging_FI; pfam14000 573235006942 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 573235006943 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 573235006944 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 573235006945 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 573235006946 tandem repeat interface [polypeptide binding]; other site 573235006947 oligomer interface [polypeptide binding]; other site 573235006948 active site residues [active] 573235006949 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 573235006950 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 573235006951 gpW; Region: gpW; pfam02831 573235006952 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 573235006953 Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471 573235006954 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 573235006955 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646 573235006956 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 573235006957 ORF11CD3 domain; Region: ORF11CD3; pfam10549 573235006958 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 573235006959 Lipoprotein Rz1 precursor; Region: Rz1; pfam06085 573235006960 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 573235006961 catalytic residues [active] 573235006962 Lysis protein S; Region: Lysis_S; pfam04971 573235006963 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 573235006964 Domain of unknown function (DUF303); Region: DUF303; pfam03629 573235006965 Protein of unknown function (DUF3927); Region: DUF3927; pfam13064 573235006966 Prophage ECO26_P14; predicted TciA/TerB, C-terminal part 573235006967 Antitermination protein; Region: Antiterm; pfam03589 573235006968 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 573235006969 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 573235006970 Protein of unknown function (DUF968); Region: DUF968; pfam06147 573235006971 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 573235006972 Hok/gef family; Region: HOK_GEF; pfam01848 573235006973 Hok/gef family; Region: HOK_GEF; pfam01848 573235006974 Protein of unknown function (DUF551); Region: DUF551; pfam04448 573235006975 Protein of unknown function (DUF4014); Region: DUF4014; pfam13198 573235006976 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG1710 573235006977 Protein of unknown function (DUF1627); Region: DUF1627; pfam07789 573235006978 Prophage ECO26_P14; replication protein, C-terminal part 573235006979 Helix-turn-helix domain; Region: HTH_36; pfam13730 573235006980 primosomal protein DnaI; Provisional; Region: PRK02854 573235006981 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 573235006982 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 573235006983 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573235006984 sequence-specific DNA binding site [nucleotide binding]; other site 573235006985 salt bridge; other site 573235006986 transcriptional repressor DicA; Reviewed; Region: PRK09706 573235006987 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 573235006988 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 573235006989 FtsZ inhibitor protein; Reviewed; Region: kil; PRK11354 573235006990 hypothetical protein; Reviewed; Region: PRK09790 573235006991 exonuclease VIII; Reviewed; Region: PRK09709 573235006992 Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630 573235006993 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 573235006994 recombination and repair protein RecT; Reviewed; Region: recT; PRK09846 573235006995 restriction alleviation and modification protein; Reviewed; Region: lar; PRK09710 573235006996 hypothetical protein; Provisional; Region: PRK09750 573235006997 Excisionase-like protein; Region: Exc; pfam07825 573235006998 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 573235006999 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 573235007000 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 573235007001 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 573235007002 dimer interface [polypeptide binding]; other site 573235007003 active site 573235007004 Int/Topo IB signature motif; other site 573235007005 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 573235007006 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 573235007007 hypothetical protein; Provisional; Region: PRK10301 573235007008 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 573235007009 Predicted amidohydrolase [General function prediction only]; Region: COG0388 573235007010 Carbon-nitrogen hydrolase; Region: CN_hydrolase; pfam00795 573235007011 exodeoxyribonuclease X; Provisional; Region: PRK07983 573235007012 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 573235007013 active site 573235007014 catalytic site [active] 573235007015 substrate binding site [chemical binding]; other site 573235007016 protease 2; Provisional; Region: PRK10115 573235007017 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 573235007018 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 573235007019 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 573235007020 putative metal binding site [ion binding]; other site 573235007021 hypothetical protein; Provisional; Region: PRK13680 573235007022 DNA damage-inducible protein YebG; Provisional; Region: PRK10061 573235007023 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 573235007024 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573235007025 ATP-grasp domain; Region: ATP-grasp; pfam02222 573235007026 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 573235007027 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 573235007028 active site 573235007029 intersubunit interface [polypeptide binding]; other site 573235007030 catalytic residue [active] 573235007031 phosphogluconate dehydratase; Validated; Region: PRK09054 573235007032 6-phosphogluconate dehydratase; Region: edd; TIGR01196 573235007033 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 573235007034 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 573235007035 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 573235007036 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 573235007037 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 573235007038 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 573235007039 putative active site [active] 573235007040 pyruvate kinase; Provisional; Region: PRK05826 573235007041 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 573235007042 domain interfaces; other site 573235007043 active site 573235007044 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 573235007045 Putative esterase; Region: Esterase; pfam00756 573235007046 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 573235007047 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 573235007048 Amidohydrolase; Region: Amidohydro_2; pfam04909 573235007049 active site 573235007050 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 573235007051 homodimer interface [polypeptide binding]; other site 573235007052 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 573235007053 active site 573235007054 homodimer interface [polypeptide binding]; other site 573235007055 catalytic site [active] 573235007056 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573235007057 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573235007058 dimer interface [polypeptide binding]; other site 573235007059 conserved gate region; other site 573235007060 putative PBP binding loops; other site 573235007061 ABC-ATPase subunit interface; other site 573235007062 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 573235007063 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573235007064 dimer interface [polypeptide binding]; other site 573235007065 conserved gate region; other site 573235007066 putative PBP binding loops; other site 573235007067 ABC-ATPase subunit interface; other site 573235007068 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 573235007069 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 573235007070 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 573235007071 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 573235007072 trimer interface [polypeptide binding]; other site 573235007073 active site 573235007074 UDP-GlcNAc binding site [chemical binding]; other site 573235007075 lipid binding site [chemical binding]; lipid-binding site 573235007076 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 573235007077 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 573235007078 Walker A/P-loop; other site 573235007079 ATP binding site [chemical binding]; other site 573235007080 Q-loop/lid; other site 573235007081 ABC transporter signature motif; other site 573235007082 Walker B; other site 573235007083 D-loop; other site 573235007084 H-loop/switch region; other site 573235007085 TOBE domain; Region: TOBE; pfam03459 573235007086 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 573235007087 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 573235007088 C-terminal domain interface [polypeptide binding]; other site 573235007089 sugar binding site [chemical binding]; other site 573235007090 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 573235007091 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 573235007092 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 573235007093 active site 573235007094 catalytic site [active] 573235007095 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261 573235007096 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 573235007097 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 573235007098 putative acyl-acceptor binding pocket; other site 573235007099 putative peptidase; Provisional; Region: PRK11649 573235007100 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 573235007101 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 573235007102 Peptidase family M23; Region: Peptidase_M23; pfam01551 573235007103 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 573235007104 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 573235007105 metal binding site [ion binding]; metal-binding site 573235007106 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 573235007107 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 573235007108 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 573235007109 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 573235007110 ABC-ATPase subunit interface; other site 573235007111 dimer interface [polypeptide binding]; other site 573235007112 putative PBP binding regions; other site 573235007113 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 573235007114 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573235007115 Walker A motif; other site 573235007116 ATP binding site [chemical binding]; other site 573235007117 Walker B motif; other site 573235007118 arginine finger; other site 573235007119 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 573235007120 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 573235007121 RuvA N terminal domain; Region: RuvA_N; pfam01330 573235007122 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 573235007123 hypothetical protein; Provisional; Region: PRK11470 573235007124 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 573235007125 active site 573235007126 putative DNA-binding cleft [nucleotide binding]; other site 573235007127 dimer interface [polypeptide binding]; other site 573235007128 hypothetical protein; Validated; Region: PRK00110 573235007129 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 573235007130 nudix motif; other site 573235007131 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 573235007132 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 573235007133 dimer interface [polypeptide binding]; other site 573235007134 anticodon binding site; other site 573235007135 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 573235007136 homodimer interface [polypeptide binding]; other site 573235007137 motif 1; other site 573235007138 active site 573235007139 motif 2; other site 573235007140 GAD domain; Region: GAD; pfam02938 573235007141 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 573235007142 motif 3; other site 573235007143 Isochorismatase family; Region: Isochorismatase; pfam00857 573235007144 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 573235007145 catalytic triad [active] 573235007146 conserved cis-peptide bond; other site 573235007147 hypothetical protein; Provisional; Region: PRK10302 573235007148 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 573235007149 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573235007150 S-adenosylmethionine binding site [chemical binding]; other site 573235007151 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573235007152 S-adenosylmethionine binding site [chemical binding]; other site 573235007153 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 573235007154 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 573235007155 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 573235007156 molybdopterin cofactor binding site [chemical binding]; other site 573235007157 substrate binding site [chemical binding]; other site 573235007158 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 573235007159 molybdopterin cofactor binding site; other site 573235007160 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 573235007161 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 573235007162 copper homeostasis protein CutC; Provisional; Region: PRK11572 573235007163 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 573235007164 putative metal binding site [ion binding]; other site 573235007165 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 573235007166 arginyl-tRNA synthetase; Region: argS; TIGR00456 573235007167 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 573235007168 active site 573235007169 HIGH motif; other site 573235007170 KMSK motif region; other site 573235007171 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 573235007172 tRNA binding surface [nucleotide binding]; other site 573235007173 anticodon binding site; other site 573235007174 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 573235007175 Flagellar protein FlhE; Region: FlhE; pfam06366 573235007176 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 573235007177 FHIPEP family; Region: FHIPEP; pfam00771 573235007178 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 573235007179 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 573235007180 chemotaxis regulator CheZ; Provisional; Region: PRK11166 573235007181 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 573235007182 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573235007183 active site 573235007184 phosphorylation site [posttranslational modification] 573235007185 intermolecular recognition site; other site 573235007186 dimerization interface [polypeptide binding]; other site 573235007187 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 573235007188 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573235007189 active site 573235007190 phosphorylation site [posttranslational modification] 573235007191 intermolecular recognition site; other site 573235007192 dimerization interface [polypeptide binding]; other site 573235007193 CheB methylesterase; Region: CheB_methylest; pfam01339 573235007194 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 573235007195 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 573235007196 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573235007197 S-adenosylmethionine binding site [chemical binding]; other site 573235007198 methyl-accepting protein IV; Provisional; Region: PRK09793 573235007199 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 573235007200 dimer interface [polypeptide binding]; other site 573235007201 ligand binding site [chemical binding]; other site 573235007202 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573235007203 dimerization interface [polypeptide binding]; other site 573235007204 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573235007205 dimer interface [polypeptide binding]; other site 573235007206 putative CheW interface [polypeptide binding]; other site 573235007207 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 573235007208 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 573235007209 dimer interface [polypeptide binding]; other site 573235007210 ligand binding site [chemical binding]; other site 573235007211 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573235007212 dimerization interface [polypeptide binding]; other site 573235007213 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573235007214 dimer interface [polypeptide binding]; other site 573235007215 putative CheW interface [polypeptide binding]; other site 573235007216 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 573235007217 putative CheA interaction surface; other site 573235007218 chemotaxis protein CheA; Provisional; Region: PRK10547 573235007219 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 573235007220 putative binding surface; other site 573235007221 active site 573235007222 CheY binding; Region: CheY-binding; pfam09078 573235007223 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 573235007224 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573235007225 ATP binding site [chemical binding]; other site 573235007226 Mg2+ binding site [ion binding]; other site 573235007227 G-X-G motif; other site 573235007228 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 573235007229 flagellar motor protein MotB; Validated; Region: motB; PRK09041 573235007230 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 573235007231 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 573235007232 ligand binding site [chemical binding]; other site 573235007233 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 573235007234 flagellar motor protein MotA; Validated; Region: PRK09110 573235007235 transcriptional activator FlhC; Provisional; Region: PRK12722 573235007236 transcriptional activator FlhD; Provisional; Region: PRK02909 573235007237 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 573235007238 Ligand Binding Site [chemical binding]; other site 573235007239 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 573235007240 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 573235007241 active site 573235007242 homotetramer interface [polypeptide binding]; other site 573235007243 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187 573235007244 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 573235007245 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 573235007246 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573235007247 TM-ABC transporter signature motif; other site 573235007248 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 573235007249 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 573235007250 Walker A/P-loop; other site 573235007251 ATP binding site [chemical binding]; other site 573235007252 Q-loop/lid; other site 573235007253 ABC transporter signature motif; other site 573235007254 Walker B; other site 573235007255 D-loop; other site 573235007256 H-loop/switch region; other site 573235007257 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 573235007258 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 573235007259 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 573235007260 ligand binding site [chemical binding]; other site 573235007261 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 573235007262 Ferritin-like domain; Region: Ferritin; pfam00210 573235007263 ferroxidase diiron center [ion binding]; other site 573235007264 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 573235007265 YecR-like lipoprotein; Region: YecR; pfam13992 573235007266 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 573235007267 Ferritin-like domain; Region: Ferritin; pfam00210 573235007268 ferroxidase diiron center [ion binding]; other site 573235007269 probable metal-binding protein; Region: matur_matur; TIGR03853 573235007270 tyrosine transporter TyrP; Provisional; Region: PRK15132 573235007271 aromatic amino acid transport protein; Region: araaP; TIGR00837 573235007272 hypothetical protein; Provisional; Region: PRK10396 573235007273 yecA family protein; Region: ygfB_yecA; TIGR02292 573235007274 SEC-C motif; Region: SEC-C; pfam02810 573235007275 Prophage ECO26_P15, P2-like phage 573235007276 integrase; Provisional; Region: int; PHA02601 573235007277 Phage HP1 integrase, C-terminal catalytic domain. Bacteriophage HP1 and related integrases are found in eubacteria, plasmids and temperate bacteriophages of the P2 family. They belong to the DNA breaking-rejoining enzyme superfamily, which includes...; Region: HP1_INT_C; cd00797 573235007278 dimer interface [polypeptide binding]; other site 573235007279 active site 573235007280 catalytic residues [active] 573235007281 Int/Topo IB signature motif; other site 573235007282 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 573235007283 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 573235007284 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 573235007285 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 573235007286 Mg binding site [ion binding]; other site 573235007287 nucleotide binding site [chemical binding]; other site 573235007288 putative protofilament interface [polypeptide binding]; other site 573235007289 Plasmid stability protein; Region: Plasmid_stab_B; pfam10784 573235007290 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 573235007291 Phage-related protein [Function unknown]; Region: COG4695; cl01923 573235007292 Phage portal protein; Region: Phage_portal; pfam04860 573235007293 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 573235007294 terminase ATPase subunit; Provisional; Region: P; PHA02535 573235007295 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 573235007296 Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947 573235007297 terminase endonuclease subunit; Provisional; Region: M; PHA02537 573235007298 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 573235007299 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 573235007300 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 573235007301 Phage holin family (Lysis protein S); Region: Phage_holin_3; cl04938 573235007302 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 573235007303 Protein of unknown function (DUF2570); Region: DUF2570; pfam10828 573235007304 Domain of unknown function (DUF1737); Region: DUF1737; cl10503 573235007305 Domain of unknown function (DUF303); Region: DUF303; pfam03629 573235007306 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 573235007307 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 573235007308 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 573235007309 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 573235007310 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 573235007311 Baseplate J-like protein; Region: Baseplate_J; cl01294 573235007312 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; pfam09684 573235007313 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 573235007314 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 573235007315 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 573235007316 Phage Tail Collar Domain; Region: Collar; pfam07484 573235007317 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 573235007318 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 573235007319 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 573235007320 trimer interface [polypeptide binding]; other site 573235007321 active site 573235007322 substrate binding site [chemical binding]; other site 573235007323 CoA binding site [chemical binding]; other site 573235007324 Phage protein U [General function prediction only]; Region: COG3499 573235007325 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 573235007326 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 573235007327 Phage tail tube protein FII; Region: Phage_tube; cl01390 573235007328 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 573235007329 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 573235007330 SEC-C motif; Region: SEC-C; pfam02810 573235007331 DNA-binding transcriptional regulator; Provisional; Region: PRK09678 573235007332 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 573235007333 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 573235007334 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 573235007335 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 573235007336 GIY-YIG motif/motif A; other site 573235007337 active site 573235007338 catalytic site [active] 573235007339 putative DNA binding site [nucleotide binding]; other site 573235007340 metal binding site [ion binding]; metal-binding site 573235007341 UvrB/uvrC motif; Region: UVR; pfam02151 573235007342 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 573235007343 Helix-hairpin-helix motif; Region: HHH; pfam00633 573235007344 response regulator; Provisional; Region: PRK09483 573235007345 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573235007346 active site 573235007347 phosphorylation site [posttranslational modification] 573235007348 intermolecular recognition site; other site 573235007349 dimerization interface [polypeptide binding]; other site 573235007350 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573235007351 DNA binding residues [nucleotide binding] 573235007352 dimerization interface [polypeptide binding]; other site 573235007353 hypothetical protein; Provisional; Region: PRK10613 573235007354 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 573235007355 Autoinducer binding domain; Region: Autoind_bind; pfam03472 573235007356 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573235007357 DNA binding residues [nucleotide binding] 573235007358 dimerization interface [polypeptide binding]; other site 573235007359 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 573235007360 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 573235007361 Walker A/P-loop; other site 573235007362 ATP binding site [chemical binding]; other site 573235007363 Q-loop/lid; other site 573235007364 ABC transporter signature motif; other site 573235007365 Walker B; other site 573235007366 D-loop; other site 573235007367 H-loop/switch region; other site 573235007368 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 573235007369 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573235007370 dimer interface [polypeptide binding]; other site 573235007371 conserved gate region; other site 573235007372 putative PBP binding loops; other site 573235007373 ABC-ATPase subunit interface; other site 573235007374 D-cysteine desulfhydrase; Validated; Region: PRK03910 573235007375 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 573235007376 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573235007377 catalytic residue [active] 573235007378 cystine transporter subunit; Provisional; Region: PRK11260 573235007379 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 573235007380 substrate binding pocket [chemical binding]; other site 573235007381 membrane-bound complex binding site; other site 573235007382 hinge residues; other site 573235007383 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 573235007384 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 573235007385 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573235007386 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 573235007387 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573235007388 DNA binding residues [nucleotide binding] 573235007389 flagellin; Validated; Region: PRK08026 573235007390 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 573235007391 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 573235007392 flagellar capping protein; Reviewed; Region: fliD; PRK08032 573235007393 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 573235007394 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 573235007395 Flagellar protein FliS; Region: FliS; cl00654 573235007396 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 573235007397 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 573235007398 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 573235007399 active site 573235007400 Na/Ca binding site [ion binding]; other site 573235007401 catalytic site [active] 573235007402 lipoprotein; Provisional; Region: PRK10397 573235007403 putative inner membrane protein; Provisional; Region: PRK11099 573235007404 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 573235007405 CPxP motif; other site 573235007406 hypothetical protein; Provisional; Region: PRK09951 573235007407 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 573235007408 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 573235007409 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 573235007410 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 573235007411 flagellar motor switch protein FliG; Region: fliG; TIGR00207 573235007412 FliG C-terminal domain; Region: FliG_C; pfam01706 573235007413 flagellar assembly protein H; Validated; Region: fliH; PRK05687 573235007414 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 573235007415 Flagellar assembly protein FliH; Region: FliH; pfam02108 573235007416 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 573235007417 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 573235007418 Walker A motif/ATP binding site; other site 573235007419 Walker B motif; other site 573235007420 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 573235007421 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 573235007422 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 573235007423 flagellar hook-length control protein; Provisional; Region: PRK10118 573235007424 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 573235007425 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 573235007426 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 573235007427 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 573235007428 flagellar motor switch protein; Validated; Region: fliN; PRK05698 573235007429 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 573235007430 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 573235007431 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 573235007432 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 573235007433 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 573235007434 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573235007435 DNA binding residues [nucleotide binding] 573235007436 dimerization interface [polypeptide binding]; other site 573235007437 hypothetical protein; Provisional; Region: PRK10708 573235007438 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 573235007439 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 573235007440 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573235007441 active site 573235007442 motif I; other site 573235007443 motif II; other site 573235007444 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 573235007445 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573235007446 metal binding site [ion binding]; metal-binding site 573235007447 active site 573235007448 I-site; other site 573235007449 Uncharacterized small protein [Function unknown]; Region: COG5475 573235007450 hypothetical protein; Provisional; Region: PRK10062 573235007451 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 573235007452 EamA-like transporter family; Region: EamA; pfam00892 573235007453 DNA mismatch endonuclease Vsr of very short patch repair, C-terminal part 573235007454 DNA cytosine methylase; Provisional; Region: PRK10458 573235007455 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 573235007456 cofactor binding site; other site 573235007457 DNA binding site [nucleotide binding] 573235007458 substrate interaction site [chemical binding]; other site 573235007459 predicted phosphohydrolase, C-terminal fragment 573235007460 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 573235007461 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 573235007462 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 573235007463 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 573235007464 Hsp31 molecular chaperone, C-terminal fragment 573235007465 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 573235007466 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573235007467 dimer interface [polypeptide binding]; other site 573235007468 phosphorylation site [posttranslational modification] 573235007469 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573235007470 ATP binding site [chemical binding]; other site 573235007471 Mg2+ binding site [ion binding]; other site 573235007472 G-X-G motif; other site 573235007473 transcriptional regulatory protein YedW; Provisional; Region: PRK11517 573235007474 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573235007475 active site 573235007476 phosphorylation site [posttranslational modification] 573235007477 intermolecular recognition site; other site 573235007478 dimerization interface [polypeptide binding]; other site 573235007479 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573235007480 DNA binding site [nucleotide binding] 573235007481 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 573235007482 active site 573235007483 homotetramer interface [polypeptide binding]; other site 573235007484 TMAO/DMSO reductase; Reviewed; Region: PRK05363 573235007485 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 573235007486 Moco binding site; other site 573235007487 metal coordination site [ion binding]; other site 573235007488 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 573235007489 zinc/cadmium-binding protein; Provisional; Region: PRK10306 573235007490 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 573235007491 Integrative element ECO26_IE03 573235007492 Integrative element ECO26_IE03; predicted integrase, C-terminal part 573235007493 muropeptide transporter; Validated; Region: ampG; cl17669 573235007494 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 573235007495 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573235007496 Walker A/P-loop; other site 573235007497 ATP binding site [chemical binding]; other site 573235007498 Q-loop/lid; other site 573235007499 ABC transporter signature motif; other site 573235007500 Walker B; other site 573235007501 D-loop; other site 573235007502 H-loop/switch region; other site 573235007503 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573235007504 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 573235007505 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573235007506 Walker A/P-loop; other site 573235007507 ATP binding site [chemical binding]; other site 573235007508 Q-loop/lid; other site 573235007509 ABC transporter signature motif; other site 573235007510 Walker B; other site 573235007511 D-loop; other site 573235007512 H-loop/switch region; other site 573235007513 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 573235007514 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573235007515 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 573235007516 Condensation domain; Region: Condensation; pfam00668 573235007517 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 573235007518 Nonribosomal peptide synthase; Region: NRPS; pfam08415 573235007519 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 573235007520 acyl-activating enzyme (AAE) consensus motif; other site 573235007521 AMP binding site [chemical binding]; other site 573235007522 Methyltransferase domain; Region: Methyltransf_23; pfam13489 573235007523 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573235007524 S-adenosylmethionine binding site [chemical binding]; other site 573235007525 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 573235007526 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 573235007527 Condensation domain; Region: Condensation; pfam00668 573235007528 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 573235007529 Nonribosomal peptide synthase; Region: NRPS; pfam08415 573235007530 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 573235007531 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 573235007532 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 573235007533 active site 573235007534 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 573235007535 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 573235007536 Methyltransferase domain; Region: Methyltransf_12; pfam08242 573235007537 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 573235007538 KR domain; Region: KR; pfam08659 573235007539 NADP binding site [chemical binding]; other site 573235007540 active site 573235007541 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 573235007542 Condensation domain; Region: Condensation; pfam00668 573235007543 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 573235007544 Nonribosomal peptide synthase; Region: NRPS; pfam08415 573235007545 Methyltransferase domain; Region: Methyltransf_12; pfam08242 573235007546 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 573235007547 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 573235007548 Oxidoreductase (NAD-binding), involved in siderophore biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PchG; COG4693 573235007549 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 573235007550 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 573235007551 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 573235007552 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 573235007553 acyl-activating enzyme (AAE) consensus motif; other site 573235007554 active site 573235007555 AMP binding site [chemical binding]; other site 573235007556 substrate binding site [chemical binding]; other site 573235007557 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 573235007558 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 573235007559 N-terminal plug; other site 573235007560 ligand-binding site [chemical binding]; other site 573235007561 predicted invasin, N-terminal part 573235007562 predicted invasin, middle part 573235007563 predicted invasin, C-terminal part 573235007564 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 573235007565 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 573235007566 shikimate transporter; Provisional; Region: PRK09952 573235007567 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235007568 putative substrate translocation pore; other site 573235007569 AMP nucleosidase; Provisional; Region: PRK08292 573235007570 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 573235007571 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 573235007572 hypothetical protein; Provisional; Region: PRK12378 573235007573 MATE family multidrug exporter; Provisional; Region: PRK10189 573235007574 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 573235007575 DNA-binding transcriptional activator Cbl of cysteine biosynthesis, N-terminal part 573235007576 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 573235007577 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573235007578 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 573235007579 putative dimerization interface [polypeptide binding]; other site 573235007580 L,D-transpeptidase; Provisional; Region: PRK10190 573235007581 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 573235007582 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 573235007583 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 573235007584 putative dimer interface [polypeptide binding]; other site 573235007585 active site pocket [active] 573235007586 putative cataytic base [active] 573235007587 cobalamin 5'-phosphate synthase/cobalamin synthase; Region: cobS; TIGR00317 573235007588 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 573235007589 homotrimer interface [polypeptide binding]; other site 573235007590 Walker A motif; other site 573235007591 GTP binding site [chemical binding]; other site 573235007592 Walker B motif; other site 573235007593 predicted transposase InsF of insertion sequence IS3, N-terminal fragment 573235007594 Transposase; Region: HTH_Tnp_1; cl17663 573235007595 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 573235007596 predicted phosphotriesterase, C-terminal part 573235007597 predicted transposase, C-terminal fragment 573235007598 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 573235007599 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 573235007600 Transposase; Region: DEDD_Tnp_IS110; pfam01548 573235007601 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 573235007602 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 573235007603 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 573235007604 hemolysin expression modulating protein Hha, C-terminal part 573235007605 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 573235007606 conserved predicted protein, C-terminal part 573235007607 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 573235007608 homodimer interface [polypeptide binding]; other site 573235007609 putative GKAP docking site [polypeptide binding]; other site 573235007610 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 573235007611 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573235007612 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 573235007613 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 573235007614 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 573235007615 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573235007616 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 573235007617 Transposase; Region: HTH_Tnp_1; pfam01527 573235007618 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 573235007619 conserved predicted protein, N-terminal part 573235007620 Predicted GTPase [General function prediction only]; Region: COG3596 573235007621 YfjP GTPase; Region: YfjP; cd11383 573235007622 G1 box; other site 573235007623 GTP/Mg2+ binding site [chemical binding]; other site 573235007624 Switch I region; other site 573235007625 G2 box; other site 573235007626 Switch II region; other site 573235007627 G3 box; other site 573235007628 G4 box; other site 573235007629 G5 box; other site 573235007630 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 573235007631 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 573235007632 hypothetical protein; Provisional; Region: PRK09945 573235007633 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 573235007634 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 573235007635 Autotransporter beta-domain; Region: Autotransporter; smart00869 573235007636 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 573235007637 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573235007638 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 573235007639 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 573235007640 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 573235007641 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573235007642 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 573235007643 Transposase; Region: HTH_Tnp_1; pfam01527 573235007644 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 573235007645 conserved predicted protein, C-terminal part 573235007646 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 573235007647 Domain of unknown function (DUF932); Region: DUF932; pfam06067 573235007648 Antirestriction protein; Region: Antirestrict; pfam03230 573235007649 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 573235007650 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 573235007651 MPN+ (JAMM) motif; other site 573235007652 Zinc-binding site [ion binding]; other site 573235007653 Protein of unknown function (DUF987); Region: DUF987; pfam06174 573235007654 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 573235007655 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 573235007656 predicted transposase, C-terminal fragment 573235007657 hypothetical protein; Provisional; Region: PRK05423 573235007658 Predicted membrane protein [Function unknown]; Region: COG1289 573235007659 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 573235007660 DNA gyrase inhibitor; Provisional; Region: PRK10016 573235007661 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 573235007662 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 573235007663 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 573235007664 exonuclease I; Provisional; Region: sbcB; PRK11779 573235007665 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 573235007666 active site 573235007667 catalytic site [active] 573235007668 substrate binding site [chemical binding]; other site 573235007669 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 573235007670 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 573235007671 CPxP motif; other site 573235007672 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 573235007673 Sulphur transport; Region: Sulf_transp; pfam04143 573235007674 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 573235007675 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573235007676 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 573235007677 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 573235007678 dimerization interface [polypeptide binding]; other site 573235007679 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 573235007680 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 573235007681 putative NAD(P) binding site [chemical binding]; other site 573235007682 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 573235007683 antitoxin YefM; Provisional; Region: PRK11409 573235007684 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 573235007685 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 573235007686 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 573235007687 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 573235007688 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 573235007689 NAD binding site [chemical binding]; other site 573235007690 dimerization interface [polypeptide binding]; other site 573235007691 product binding site; other site 573235007692 substrate binding site [chemical binding]; other site 573235007693 zinc binding site [ion binding]; other site 573235007694 catalytic residues [active] 573235007695 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 573235007696 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573235007697 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573235007698 homodimer interface [polypeptide binding]; other site 573235007699 catalytic residue [active] 573235007700 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 573235007701 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573235007702 active site 573235007703 motif I; other site 573235007704 motif II; other site 573235007705 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 573235007706 putative active site pocket [active] 573235007707 4-fold oligomerization interface [polypeptide binding]; other site 573235007708 metal binding residues [ion binding]; metal-binding site 573235007709 3-fold/trimer interface [polypeptide binding]; other site 573235007710 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 573235007711 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 573235007712 putative active site [active] 573235007713 oxyanion strand; other site 573235007714 catalytic triad [active] 573235007715 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 573235007716 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 573235007717 catalytic residues [active] 573235007718 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 573235007719 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 573235007720 substrate binding site [chemical binding]; other site 573235007721 glutamase interaction surface [polypeptide binding]; other site 573235007722 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 573235007723 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 573235007724 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 573235007725 metal binding site [ion binding]; metal-binding site 573235007726 chain length determinant protein WzzB; Provisional; Region: PRK15471 573235007727 Chain length determinant protein; Region: Wzz; pfam02706 573235007728 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 573235007729 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 573235007730 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 573235007731 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 573235007732 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 573235007733 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 573235007734 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 573235007735 cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366 573235007736 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573235007737 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 573235007738 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 573235007739 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 573235007740 active site 573235007741 homodimer interface [polypeptide binding]; other site 573235007742 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 573235007743 capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261 573235007744 putative NAD(P) binding site [chemical binding]; other site 573235007745 active site 573235007746 putative substrate binding site [chemical binding]; other site 573235007747 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 573235007748 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 573235007749 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 573235007750 NAD(P) binding site [chemical binding]; other site 573235007751 homodimer interface [polypeptide binding]; other site 573235007752 substrate binding site [chemical binding]; other site 573235007753 active site 573235007754 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 573235007755 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 573235007756 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 573235007757 active site 573235007758 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 573235007759 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 573235007760 glucose-1-phosphate thymidylyltransferase RfbA; Provisional; Region: PRK15480 573235007761 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 573235007762 substrate binding site; other site 573235007763 tetramer interface; other site 573235007764 dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987 573235007765 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 573235007766 NADP binding site [chemical binding]; other site 573235007767 active site 573235007768 putative substrate binding site [chemical binding]; other site 573235007769 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 573235007770 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 573235007771 NAD binding site [chemical binding]; other site 573235007772 substrate binding site [chemical binding]; other site 573235007773 homodimer interface [polypeptide binding]; other site 573235007774 active site 573235007775 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 573235007776 active site 573235007777 tetramer interface; other site 573235007778 putative colanic acid biosynthesis protein; Provisional; Region: wcaM; PRK10123 573235007779 colanic acid biosynthesis glycosyltransferase WcaL; Region: wcaL; TIGR04005 573235007780 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 573235007781 putative ADP-binding pocket [chemical binding]; other site 573235007782 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 573235007783 colanic acid biosynthesis pyruvyl transferase WcaK; Region: wcaK; TIGR04006 573235007784 colanic acid exporter; Provisional; Region: PRK10459 573235007785 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 573235007786 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 573235007787 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 573235007788 phosphomannomutase CpsG; Provisional; Region: PRK15414 573235007789 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 573235007790 active site 573235007791 substrate binding site [chemical binding]; other site 573235007792 metal binding site [ion binding]; metal-binding site 573235007793 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 573235007794 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 573235007795 Substrate binding site; other site 573235007796 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 573235007797 colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007 573235007798 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 573235007799 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 573235007800 active site 573235007801 GDP-Mannose binding site [chemical binding]; other site 573235007802 dimer interface [polypeptide binding]; other site 573235007803 modified nudix motif 573235007804 metal binding site [ion binding]; metal-binding site 573235007805 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 573235007806 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 573235007807 NADP binding site [chemical binding]; other site 573235007808 active site 573235007809 putative substrate binding site [chemical binding]; other site 573235007810 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 573235007811 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 573235007812 NADP-binding site; other site 573235007813 homotetramer interface [polypeptide binding]; other site 573235007814 substrate binding site [chemical binding]; other site 573235007815 homodimer interface [polypeptide binding]; other site 573235007816 active site 573235007817 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 573235007818 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 573235007819 putative trimer interface [polypeptide binding]; other site 573235007820 putative active site [active] 573235007821 putative substrate binding site [chemical binding]; other site 573235007822 putative CoA binding site [chemical binding]; other site 573235007823 putative glycosyl transferase; Provisional; Region: PRK10063 573235007824 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 573235007825 metal-binding site 573235007826 putative colanic acid polymerase WcaD; Region: WcaD; TIGR04010 573235007827 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 573235007828 colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015 573235007829 putative acyl transferase; Provisional; Region: PRK10191 573235007830 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 573235007831 trimer interface [polypeptide binding]; other site 573235007832 active site 573235007833 substrate binding site [chemical binding]; other site 573235007834 CoA binding site [chemical binding]; other site 573235007835 putative glycosyl transferase; Provisional; Region: PRK10018 573235007836 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 573235007837 active site 573235007838 tyrosine kinase; Provisional; Region: PRK11519 573235007839 Chain length determinant protein; Region: Wzz; pfam02706 573235007840 Chain length determinant protein; Region: Wzz; cl15801 573235007841 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 573235007842 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 573235007843 Low molecular weight phosphatase family; Region: LMWPc; cd00115 573235007844 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 573235007845 active site 573235007846 polysaccharide export protein Wza; Provisional; Region: PRK15078 573235007847 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 573235007848 SLBB domain; Region: SLBB; pfam10531 573235007849 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 573235007850 FOG: CBS domain [General function prediction only]; Region: COG0517 573235007851 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 573235007852 Transporter associated domain; Region: CorC_HlyC; smart01091 573235007853 putative assembly protein; Provisional; Region: PRK10833 573235007854 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 573235007855 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 573235007856 trimer interface [polypeptide binding]; other site 573235007857 active site 573235007858 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 573235007859 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 573235007860 ATP-binding site [chemical binding]; other site 573235007861 Sugar specificity; other site 573235007862 Pyrimidine base specificity; other site 573235007863 predicted diguanylate cyclase, GGDEF domain signalling protein, N-terminal fragment 573235007864 predicted diguanylate cyclase, GGDEF domain signalling protein, C-terminal fragment 573235007865 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 573235007866 AlkA N-terminal domain; Region: AlkA_N; smart01009 573235007867 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 573235007868 minor groove reading motif; other site 573235007869 helix-hairpin-helix signature motif; other site 573235007870 substrate binding pocket [chemical binding]; other site 573235007871 active site 573235007872 putative chaperone; Provisional; Region: PRK11678 573235007873 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 573235007874 nucleotide binding site [chemical binding]; other site 573235007875 putative NEF/HSP70 interaction site [polypeptide binding]; other site 573235007876 SBD interface [polypeptide binding]; other site 573235007877 conserved predicted protein, C-terminal part 573235007878 conserved predicted protein, N-terminal part 573235007879 Protein phosphatase 2C; Region: PP2C_2; pfam13672 573235007880 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 573235007881 metal ion-dependent adhesion site (MIDAS); other site 573235007882 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 573235007883 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 573235007884 HlyD family secretion protein; Region: HlyD_3; pfam13437 573235007885 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 573235007886 Protein export membrane protein; Region: SecD_SecF; cl14618 573235007887 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 573235007888 putative transporter; Provisional; Region: PRK10504 573235007889 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235007890 putative substrate translocation pore; other site 573235007891 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235007892 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 573235007893 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573235007894 dimerization interface [polypeptide binding]; other site 573235007895 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573235007896 dimer interface [polypeptide binding]; other site 573235007897 phosphorylation site [posttranslational modification] 573235007898 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573235007899 ATP binding site [chemical binding]; other site 573235007900 Mg2+ binding site [ion binding]; other site 573235007901 G-X-G motif; other site 573235007902 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 573235007903 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573235007904 active site 573235007905 phosphorylation site [posttranslational modification] 573235007906 intermolecular recognition site; other site 573235007907 dimerization interface [polypeptide binding]; other site 573235007908 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573235007909 DNA binding site [nucleotide binding] 573235007910 Uncharacterized conserved protein [Function unknown]; Region: COG3422 573235007911 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 573235007912 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 573235007913 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 573235007914 putative protease; Provisional; Region: PRK15452 573235007915 Peptidase family U32; Region: Peptidase_U32; pfam01136 573235007916 lipid kinase; Reviewed; Region: PRK13054 573235007917 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 573235007918 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 573235007919 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 573235007920 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 573235007921 galactitol-1-phosphate dehydrogenase, Zn-dependent and NAD(P)-binding, C-terminal fragment 573235007922 galactitol-1-phosphate dehydrogenase, Zn-dependent and NAD(P)-binding, N-terminal fragment 573235007923 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 573235007924 PTS system, galactitol-specific IIC component; Region: EIIC-GAT; TIGR00827 573235007925 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 573235007926 active site 573235007927 P-loop; other site 573235007928 phosphorylation site [posttranslational modification] 573235007929 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 573235007930 active site 573235007931 phosphorylation site [posttranslational modification] 573235007932 D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052 573235007933 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 573235007934 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 573235007935 intersubunit interface [polypeptide binding]; other site 573235007936 active site 573235007937 zinc binding site [ion binding]; other site 573235007938 Na+ binding site [ion binding]; other site 573235007939 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 573235007940 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 573235007941 putative active site; other site 573235007942 catalytic residue [active] 573235007943 nucleoside transporter; Region: 2A0110; TIGR00889 573235007944 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235007945 putative substrate translocation pore; other site 573235007946 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 573235007947 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 573235007948 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 573235007949 substrate binding site [chemical binding]; other site 573235007950 ATP binding site [chemical binding]; other site 573235007951 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 573235007952 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573235007953 DNA-binding site [nucleotide binding]; DNA binding site 573235007954 UTRA domain; Region: UTRA; pfam07702 573235007955 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 573235007956 YegX is an uncharacterized bacterial protein with a glycosyl hydrolase family 25 (GH25) catalytic domain that is similar in sequence to the CH-type (Chalaropsis-type) lysozymes of the GH25 family of endolysins; Region: GH25_YegX-like; cd06524 573235007957 active site 573235007958 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 573235007959 dimer interface [polypeptide binding]; other site 573235007960 substrate binding site [chemical binding]; other site 573235007961 ATP binding site [chemical binding]; other site 573235007962 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 573235007963 substrate binding site [chemical binding]; other site 573235007964 multimerization interface [polypeptide binding]; other site 573235007965 ATP binding site [chemical binding]; other site 573235007966 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 573235007967 putative metal binding site [ion binding]; other site 573235007968 putative homodimer interface [polypeptide binding]; other site 573235007969 putative homotetramer interface [polypeptide binding]; other site 573235007970 putative homodimer-homodimer interface [polypeptide binding]; other site 573235007971 putative allosteric switch controlling residues; other site 573235007972 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 573235007973 Predicted integral membrane protein [Function unknown]; Region: COG5455 573235007974 putative fimbrial-like adhesin protein StcD; Provisional; Region: PRK15252 573235007975 putative fimbrial biosynthesis regulatory protein; Provisional; Region: PRK15216 573235007976 fimbrial outer membrane usher protein; Provisional; Region: PRK15217 573235007977 PapC N-terminal domain; Region: PapC_N; pfam13954 573235007978 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 573235007979 PapC C-terminal domain; Region: PapC_C; pfam13953 573235007980 putative fimbrial assembly chaperone protein StcB; Provisional; Region: PRK15253 573235007981 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 573235007982 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 573235007983 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 573235007984 Protein of unknown function (DUF2574); Region: DUF2574; pfam10836 573235007985 antiporter inner membrane protein; Provisional; Region: PRK11670 573235007986 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 573235007987 Walker A motif; other site 573235007988 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 573235007989 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 573235007990 active site 573235007991 HIGH motif; other site 573235007992 KMSKS motif; other site 573235007993 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 573235007994 tRNA binding surface [nucleotide binding]; other site 573235007995 anticodon binding site; other site 573235007996 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 573235007997 dimer interface [polypeptide binding]; other site 573235007998 putative tRNA-binding site [nucleotide binding]; other site 573235007999 predicted DNA-binding transcriptional regulator MolR, C-terminal part 573235008000 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 573235008001 MoxR-like ATPases [General function prediction only]; Region: COG0714 573235008002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573235008003 Walker A motif; other site 573235008004 ATP binding site [chemical binding]; other site 573235008005 Walker B motif; other site 573235008006 arginine finger; other site 573235008007 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 573235008008 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 573235008009 metal ion-dependent adhesion site (MIDAS); other site 573235008010 conserved predicted protein, N-terminal part 573235008011 Transposase; Region: HTH_Tnp_1; pfam01527 573235008012 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 573235008013 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573235008014 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 573235008015 predicted protein Orf3 in insertion sequence ISEc8, internal deletion 573235008016 conserved predicted protein, C-terminal part 573235008017 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 573235008018 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 573235008019 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 573235008020 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 573235008021 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573235008022 active site 573235008023 phosphorylation site [posttranslational modification] 573235008024 intermolecular recognition site; other site 573235008025 dimerization interface [polypeptide binding]; other site 573235008026 LytTr DNA-binding domain; Region: LytTR; pfam04397 573235008027 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 573235008028 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 573235008029 GAF domain; Region: GAF; pfam01590 573235008030 Histidine kinase; Region: His_kinase; pfam06580 573235008031 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573235008032 ATP binding site [chemical binding]; other site 573235008033 Mg2+ binding site [ion binding]; other site 573235008034 G-X-G motif; other site 573235008035 DNA-binding transcriptional regulator MlrA, N-terminal fragment 573235008036 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 573235008037 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573235008038 dimer interface [polypeptide binding]; other site 573235008039 conserved gate region; other site 573235008040 putative PBP binding loops; other site 573235008041 ABC-ATPase subunit interface; other site 573235008042 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 573235008043 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 573235008044 Walker A/P-loop; other site 573235008045 ATP binding site [chemical binding]; other site 573235008046 Q-loop/lid; other site 573235008047 ABC transporter signature motif; other site 573235008048 Walker B; other site 573235008049 D-loop; other site 573235008050 H-loop/switch region; other site 573235008051 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 573235008052 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573235008053 dimer interface [polypeptide binding]; other site 573235008054 conserved gate region; other site 573235008055 ABC-ATPase subunit interface; other site 573235008056 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 573235008057 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 573235008058 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 573235008059 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 573235008060 D-lactate dehydrogenase; Provisional; Region: PRK11183 573235008061 FAD binding domain; Region: FAD_binding_4; pfam01565 573235008062 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 573235008063 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 573235008064 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 573235008065 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 573235008066 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 573235008067 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 573235008068 oxidoreductase; Provisional; Region: PRK12743 573235008069 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573235008070 NAD(P) binding site [chemical binding]; other site 573235008071 active site 573235008072 multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459 573235008073 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 573235008074 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 573235008075 FMN binding site [chemical binding]; other site 573235008076 active site 573235008077 catalytic residues [active] 573235008078 substrate binding site [chemical binding]; other site 573235008079 hypothetical protein; Provisional; Region: PRK01821 573235008080 hypothetical protein; Provisional; Region: PRK10711 573235008081 cytidine deaminase; Provisional; Region: PRK09027 573235008082 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 573235008083 active site 573235008084 catalytic motif [active] 573235008085 Zn binding site [ion binding]; other site 573235008086 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 573235008087 active site 573235008088 catalytic motif [active] 573235008089 Zn binding site [ion binding]; other site 573235008090 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 573235008091 putative active site [active] 573235008092 Protein of unknown function (DUF2542); Region: DUF2542; pfam10808 573235008093 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 573235008094 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 573235008095 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 573235008096 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 573235008097 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 573235008098 homodimer interface [polypeptide binding]; other site 573235008099 active site 573235008100 FMN binding site [chemical binding]; other site 573235008101 substrate binding site [chemical binding]; other site 573235008102 4Fe-4S binding domain; Region: Fer4; pfam00037 573235008103 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573235008104 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 573235008105 TM-ABC transporter signature motif; other site 573235008106 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 573235008107 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 573235008108 Walker A/P-loop; other site 573235008109 ATP binding site [chemical binding]; other site 573235008110 Q-loop/lid; other site 573235008111 ABC transporter signature motif; other site 573235008112 Walker B; other site 573235008113 D-loop; other site 573235008114 H-loop/switch region; other site 573235008115 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 573235008116 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 573235008117 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 573235008118 ligand binding site [chemical binding]; other site 573235008119 calcium binding site [ion binding]; other site 573235008120 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 573235008121 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573235008122 DNA binding site [nucleotide binding] 573235008123 domain linker motif; other site 573235008124 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 573235008125 dimerization interface (closed form) [polypeptide binding]; other site 573235008126 ligand binding site [chemical binding]; other site 573235008127 Predicted membrane protein [Function unknown]; Region: COG2311 573235008128 hypothetical protein; Provisional; Region: PRK10835 573235008129 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 573235008130 homodecamer interface [polypeptide binding]; other site 573235008131 GTP cyclohydrolase I; Provisional; Region: PLN03044 573235008132 active site 573235008133 putative catalytic site residues [active] 573235008134 zinc binding site [ion binding]; other site 573235008135 GTP-CH-I/GFRP interaction surface; other site 573235008136 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 573235008137 S-formylglutathione hydrolase; Region: PLN02442 573235008138 catecholate siderophore receptor CirA; Provisional; Region: PRK10064 573235008139 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 573235008140 N-terminal plug; other site 573235008141 ligand-binding site [chemical binding]; other site 573235008142 lysine transporter; Provisional; Region: PRK10836 573235008143 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 573235008144 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573235008145 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 573235008146 putative dimerization interface [polypeptide binding]; other site 573235008147 conserved hypothetical integral membrane protein; Region: TIGR00698 573235008148 endonuclease IV; Provisional; Region: PRK01060 573235008149 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 573235008150 AP (apurinic/apyrimidinic) site pocket; other site 573235008151 DNA interaction; other site 573235008152 Metal-binding active site; metal-binding site 573235008153 putative kinase; Provisional; Region: PRK09954 573235008154 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573235008155 putative DNA binding site [nucleotide binding]; other site 573235008156 putative Zn2+ binding site [ion binding]; other site 573235008157 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 573235008158 substrate binding site [chemical binding]; other site 573235008159 ATP binding site [chemical binding]; other site 573235008160 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 573235008161 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 573235008162 Nucleoside recognition; Region: Gate; pfam07670 573235008163 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 573235008164 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 573235008165 active site 573235008166 tetramer interface [polypeptide binding]; other site 573235008167 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 573235008168 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 573235008169 ligand binding site [chemical binding]; other site 573235008170 flexible hinge region; other site 573235008171 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 573235008172 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 573235008173 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 573235008174 Nucleoside recognition; Region: Gate; pfam07670 573235008175 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 573235008176 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 573235008177 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 573235008178 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 573235008179 substrate binding site [chemical binding]; other site 573235008180 ATP binding site [chemical binding]; other site 573235008181 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 573235008182 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 573235008183 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 573235008184 active site 573235008185 P-loop; other site 573235008186 phosphorylation site [posttranslational modification] 573235008187 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 573235008188 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 573235008189 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 573235008190 putative substrate binding site [chemical binding]; other site 573235008191 putative ATP binding site [chemical binding]; other site 573235008192 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 573235008193 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 573235008194 active site 573235008195 phosphorylation site [posttranslational modification] 573235008196 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 573235008197 dimerization domain swap beta strand [polypeptide binding]; other site 573235008198 regulatory protein interface [polypeptide binding]; other site 573235008199 active site 573235008200 regulatory phosphorylation site [posttranslational modification]; other site 573235008201 sugar efflux transporter B; Provisional; Region: PRK15011 573235008202 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235008203 putative substrate translocation pore; other site 573235008204 Flagellin N-methylase; Region: FliB; pfam03692 573235008205 elongation factor P; Provisional; Region: PRK04542 573235008206 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 573235008207 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 573235008208 RNA binding site [nucleotide binding]; other site 573235008209 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 573235008210 RNA binding site [nucleotide binding]; other site 573235008211 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 573235008212 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 573235008213 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 573235008214 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 573235008215 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 573235008216 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 573235008217 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 573235008218 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 573235008219 active site 573235008220 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 573235008221 NlpC/P60 family; Region: NLPC_P60; pfam00877 573235008222 phage resistance protein; Provisional; Region: PRK10551 573235008223 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 573235008224 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 573235008225 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 573235008226 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 573235008227 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 573235008228 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573235008229 dimer interface [polypeptide binding]; other site 573235008230 conserved gate region; other site 573235008231 putative PBP binding loops; other site 573235008232 ABC-ATPase subunit interface; other site 573235008233 microcin C ABC transporter permease; Provisional; Region: PRK15021 573235008234 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573235008235 dimer interface [polypeptide binding]; other site 573235008236 conserved gate region; other site 573235008237 ABC-ATPase subunit interface; other site 573235008238 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 573235008239 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 573235008240 Walker A/P-loop; other site 573235008241 ATP binding site [chemical binding]; other site 573235008242 Q-loop/lid; other site 573235008243 ABC transporter signature motif; other site 573235008244 Walker B; other site 573235008245 D-loop; other site 573235008246 H-loop/switch region; other site 573235008247 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 573235008248 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 573235008249 Walker A/P-loop; other site 573235008250 ATP binding site [chemical binding]; other site 573235008251 Q-loop/lid; other site 573235008252 ABC transporter signature motif; other site 573235008253 Walker B; other site 573235008254 D-loop; other site 573235008255 H-loop/switch region; other site 573235008256 hypothetical protein; Provisional; Region: PRK11835 573235008257 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235008258 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 573235008259 putative substrate translocation pore; other site 573235008260 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 573235008261 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 573235008262 RNA binding surface [nucleotide binding]; other site 573235008263 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 573235008264 active site 573235008265 uracil binding [chemical binding]; other site 573235008266 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 573235008267 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573235008268 ATP binding site [chemical binding]; other site 573235008269 putative Mg++ binding site [ion binding]; other site 573235008270 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573235008271 nucleotide binding region [chemical binding]; other site 573235008272 ATP-binding site [chemical binding]; other site 573235008273 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 573235008274 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 573235008275 5S rRNA interface [nucleotide binding]; other site 573235008276 CTC domain interface [polypeptide binding]; other site 573235008277 L16 interface [polypeptide binding]; other site 573235008278 Nucleoid-associated protein [General function prediction only]; Region: COG3081 573235008279 nucleoid-associated protein NdpA; Validated; Region: PRK00378 573235008280 hypothetical protein; Provisional; Region: PRK13689 573235008281 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 573235008282 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 573235008283 Sulfatase; Region: Sulfatase; pfam00884 573235008284 Prophage ECO26_P16, untypable 573235008285 integrase; Provisional; Region: PRK09692 573235008286 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 573235008287 active site 573235008288 Int/Topo IB signature motif; other site 573235008289 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 573235008290 Ash protein family; Region: Phage_ASH; pfam10554 573235008291 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 573235008292 AAA domain; Region: AAA_25; pfam13481 573235008293 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 573235008294 Walker A motif; other site 573235008295 ATP binding site [chemical binding]; other site 573235008296 Walker B motif; other site 573235008297 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 573235008298 Phage capsid family; Region: Phage_capsid; pfam05065 573235008299 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 573235008300 hypothetical protein; Provisional; Region: PRK09945 573235008301 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 573235008302 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 573235008303 Autotransporter beta-domain; Region: Autotransporter; pfam03797 573235008304 transcriptional regulator NarP; Provisional; Region: PRK10403 573235008305 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573235008306 active site 573235008307 phosphorylation site [posttranslational modification] 573235008308 intermolecular recognition site; other site 573235008309 dimerization interface [polypeptide binding]; other site 573235008310 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573235008311 DNA binding residues [nucleotide binding] 573235008312 dimerization interface [polypeptide binding]; other site 573235008313 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 573235008314 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 573235008315 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573235008316 binding surface 573235008317 TPR motif; other site 573235008318 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 573235008319 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 573235008320 catalytic residues [active] 573235008321 central insert; other site 573235008322 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 573235008323 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 573235008324 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 573235008325 heme exporter protein CcmC; Region: ccmC; TIGR01191 573235008326 heme exporter protein CcmB; Region: ccmB; TIGR01190 573235008327 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 573235008328 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 573235008329 Walker A/P-loop; other site 573235008330 ATP binding site [chemical binding]; other site 573235008331 Q-loop/lid; other site 573235008332 ABC transporter signature motif; other site 573235008333 Walker B; other site 573235008334 D-loop; other site 573235008335 H-loop/switch region; other site 573235008336 cytochrome c-type protein NapC; Provisional; Region: PRK10617 573235008337 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 573235008338 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 573235008339 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 573235008340 4Fe-4S binding domain; Region: Fer4_5; pfam12801 573235008341 4Fe-4S binding domain; Region: Fer4_6; pfam12837 573235008342 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 573235008343 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 573235008344 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 573235008345 [4Fe-4S] binding site [ion binding]; other site 573235008346 molybdopterin cofactor binding site; other site 573235008347 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 573235008348 molybdopterin cofactor binding site; other site 573235008349 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 573235008350 ferredoxin-type protein; Provisional; Region: PRK10194 573235008351 tRNA synthetases class I (R); Region: tRNA-synt_1d; pfam00750 573235008352 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 573235008353 secondary substrate binding site; other site 573235008354 primary substrate binding site; other site 573235008355 inhibition loop; other site 573235008356 dimerization interface [polypeptide binding]; other site 573235008357 malate:quinone oxidoreductase; Validated; Region: PRK05257 573235008358 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 573235008359 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 573235008360 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 573235008361 Walker A/P-loop; other site 573235008362 ATP binding site [chemical binding]; other site 573235008363 Q-loop/lid; other site 573235008364 ABC transporter signature motif; other site 573235008365 Walker B; other site 573235008366 D-loop; other site 573235008367 H-loop/switch region; other site 573235008368 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 573235008369 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 573235008370 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 573235008371 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573235008372 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573235008373 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 573235008374 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 573235008375 DNA binding site [nucleotide binding] 573235008376 active site 573235008377 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 573235008378 ApbE family; Region: ApbE; pfam02424 573235008379 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 573235008380 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 573235008381 trimer interface [polypeptide binding]; other site 573235008382 eyelet of channel; other site 573235008383 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 573235008384 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573235008385 ATP binding site [chemical binding]; other site 573235008386 G-X-G motif; other site 573235008387 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 573235008388 putative binding surface; other site 573235008389 active site 573235008390 transcriptional regulator RcsB; Provisional; Region: PRK10840 573235008391 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573235008392 active site 573235008393 phosphorylation site [posttranslational modification] 573235008394 intermolecular recognition site; other site 573235008395 dimerization interface [polypeptide binding]; other site 573235008396 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573235008397 DNA binding residues [nucleotide binding] 573235008398 dimerization interface [polypeptide binding]; other site 573235008399 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 573235008400 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573235008401 dimer interface [polypeptide binding]; other site 573235008402 phosphorylation site [posttranslational modification] 573235008403 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573235008404 ATP binding site [chemical binding]; other site 573235008405 Mg2+ binding site [ion binding]; other site 573235008406 G-X-G motif; other site 573235008407 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 573235008408 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573235008409 active site 573235008410 phosphorylation site [posttranslational modification] 573235008411 intermolecular recognition site; other site 573235008412 dimerization interface [polypeptide binding]; other site 573235008413 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 573235008414 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 573235008415 Predicted secreted protein [Function unknown]; Region: COG5445 573235008416 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 573235008417 Predicted secreted protein [Function unknown]; Region: COG5445 573235008418 Stage II sporulation protein; Region: SpoIID; pfam08486 573235008419 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 573235008420 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 573235008421 MG2 domain; Region: A2M_N; pfam01835 573235008422 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 573235008423 Alpha-2-macroglobulin family; Region: A2M; pfam00207 573235008424 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 573235008425 Prophage ECO26_P17, lambda-like phage 573235008426 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 573235008427 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 573235008428 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 573235008429 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 573235008430 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 573235008431 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 573235008432 Prophage ECO26_P17; predicted host specificity protein, C-terminal fragment 573235008433 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 573235008434 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573235008435 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 573235008436 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 573235008437 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 573235008438 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573235008439 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 573235008440 Transposase; Region: HTH_Tnp_1; pfam01527 573235008441 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 573235008442 Phage-related protein, tail component [Function unknown]; Region: COG4733 573235008443 Putative phage tail protein; Region: Phage-tail_3; pfam13550 573235008444 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 573235008445 Interdomain contacts; other site 573235008446 Cytokine receptor motif; other site 573235008447 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 573235008448 Fibronectin type III protein; Region: DUF3672; pfam12421 573235008449 Phage-related protein, tail component [Function unknown]; Region: COG4723 573235008450 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 573235008451 MPN+ (JAMM) motif; other site 573235008452 Zinc-binding site [ion binding]; other site 573235008453 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 573235008454 NlpC/P60 family; Region: NLPC_P60; cl17555 573235008455 Phage-related protein [Function unknown]; Region: gp18; COG4672 573235008456 Phage-related protein [Function unknown]; Region: COG4718 573235008457 Phage-related minor tail protein [Function unknown]; Region: COG5281 573235008458 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 573235008459 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 573235008460 Minor tail protein T; Region: Phage_tail_T; cl05636 573235008461 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894 573235008462 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 573235008463 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 573235008464 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 573235008465 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 573235008466 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 573235008467 DNA packaging protein FI; Region: Packaging_FI; pfam14000 573235008468 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 573235008469 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 573235008470 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 573235008471 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 573235008472 tandem repeat interface [polypeptide binding]; other site 573235008473 oligomer interface [polypeptide binding]; other site 573235008474 active site residues [active] 573235008475 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 573235008476 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 573235008477 gpW; Region: gpW; pfam02831 573235008478 Prophage ECO26_P17; predicted terminase large subunit, C-terminal fragment 573235008479 Prophage ECO26_P17; predicted terminase large subunit, N-terminal part 573235008480 Phage DNA packaging protein, Nu1 subunit of terminase [DNA replication, recombination, and repair]; Region: COG4220 573235008481 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 573235008482 Bor protein; Region: Lambda_Bor; pfam06291 573235008483 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 573235008484 Lipoprotein Rz1 precursor; Region: Rz1; pfam06085 573235008485 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 573235008486 catalytic residues [active] 573235008487 Lysis protein S; Region: Lysis_S; pfam04971 573235008488 Protein of unknown function (DUF3927); Region: DUF3927; pfam13064 573235008489 Antitermination protein; Region: Antiterm; pfam03589 573235008490 Antitermination protein; Region: Antiterm; pfam03589 573235008491 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 573235008492 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 573235008493 active site 573235008494 metal binding site [ion binding]; metal-binding site 573235008495 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 573235008496 HNH endonuclease; Region: HNH_3; pfam13392 573235008497 AP2 domain; Region: AP2; pfam00847 573235008498 NINE Protein; Region: NinE; pfam05322 573235008499 phage N-6-adenine-methyltransferase; Region: phage_N6A_met; TIGR01712 573235008500 NinB protein; Region: NinB; pfam05772 573235008501 Replication protein P; Region: Phage_lambda_P; pfam06992 573235008502 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 573235008503 Bacteriophage CII protein; Region: Phage_CII; pfam05269 573235008504 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 573235008505 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 573235008506 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573235008507 non-specific DNA binding site [nucleotide binding]; other site 573235008508 salt bridge; other site 573235008509 sequence-specific DNA binding site [nucleotide binding]; other site 573235008510 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 573235008511 Catalytic site [active] 573235008512 Protein of unknown function (DUF2528); Region: DUF2528; pfam10800 573235008513 Bacteriophage lambda Kil protein; Region: Lambda_Kil; pfam06301 573235008514 Host-nuclease inhibitor protein Gam; Region: Gam; pfam06064 573235008515 phage recombination protein Bet; Region: bet_lambda; TIGR01913 573235008516 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 573235008517 Protein of unknown function (DUF1382); Region: DUF1382; pfam07131 573235008518 DksA-like zinc finger domain containing protein; Region: PHA00080 573235008519 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 573235008520 Protein of unknown function (DUF551); Region: DUF551; pfam04448 573235008521 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 573235008522 Excisionase-like protein; Region: Exc; pfam07825 573235008523 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 573235008524 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 573235008525 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; pfam02899 573235008526 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 573235008527 dimer interface [polypeptide binding]; other site 573235008528 active site 573235008529 Int/Topo IB signature motif; other site 573235008530 conserved predicted protein, N-terminal part 573235008531 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4685 573235008532 DNA gyrase subunit A; Validated; Region: PRK05560 573235008533 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 573235008534 CAP-like domain; other site 573235008535 active site 573235008536 primary dimer interface [polypeptide binding]; other site 573235008537 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 573235008538 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 573235008539 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 573235008540 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 573235008541 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 573235008542 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 573235008543 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 573235008544 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573235008545 S-adenosylmethionine binding site [chemical binding]; other site 573235008546 adhesin; Provisional; Region: PRK09752 573235008547 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 573235008548 Autotransporter beta-domain; Region: Autotransporter; pfam03797 573235008549 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 573235008550 ATP cone domain; Region: ATP-cone; pfam03477 573235008551 Class I ribonucleotide reductase; Region: RNR_I; cd01679 573235008552 active site 573235008553 dimer interface [polypeptide binding]; other site 573235008554 catalytic residues [active] 573235008555 effector binding site; other site 573235008556 R2 peptide binding site; other site 573235008557 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 573235008558 dimer interface [polypeptide binding]; other site 573235008559 putative radical transfer pathway; other site 573235008560 diiron center [ion binding]; other site 573235008561 tyrosyl radical; other site 573235008562 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 573235008563 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 573235008564 catalytic loop [active] 573235008565 iron binding site [ion binding]; other site 573235008566 hypothetical protein; Provisional; Region: PRK09902 573235008567 hypothetical protein; Provisional; Region: PRK09729 573235008568 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 573235008569 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 573235008570 active site 573235008571 catalytic site [active] 573235008572 metal binding site [ion binding]; metal-binding site 573235008573 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 573235008574 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235008575 putative substrate translocation pore; other site 573235008576 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 573235008577 hydroxyglutarate oxidase; Provisional; Region: PRK11728 573235008578 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 573235008579 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 573235008580 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 573235008581 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 573235008582 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 573235008583 Cysteine-rich domain; Region: CCG; pfam02754 573235008584 Cysteine-rich domain; Region: CCG; pfam02754 573235008585 hypothetical protein; Provisional; Region: PRK09956 573235008586 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 573235008587 predicted 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, C-terminal fragment 573235008588 hypothetical protein; Provisional; Region: PRK03673 573235008589 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 573235008590 putative MPT binding site; other site 573235008591 Competence-damaged protein; Region: CinA; cl00666 573235008592 YfaZ precursor; Region: YfaZ; pfam07437 573235008593 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 573235008594 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 573235008595 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 573235008596 catalytic core [active] 573235008597 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 573235008598 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 573235008599 inhibitor-cofactor binding pocket; inhibition site 573235008600 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573235008601 catalytic residue [active] 573235008602 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 573235008603 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 573235008604 Ligand binding site; other site 573235008605 Putative Catalytic site; other site 573235008606 DXD motif; other site 573235008607 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 573235008608 ArnA, N-terminal formyltransferase domain; Region: FMT_core_ArnA_N; cd08644 573235008609 substrate binding site [chemical binding]; other site 573235008610 cosubstrate binding site; other site 573235008611 catalytic site [active] 573235008612 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 573235008613 active site 573235008614 hexamer interface [polypeptide binding]; other site 573235008615 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 573235008616 NAD binding site [chemical binding]; other site 573235008617 substrate binding site [chemical binding]; other site 573235008618 active site 573235008619 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 573235008620 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 573235008621 putative active site [active] 573235008622 putative catalytic site [active] 573235008623 putative Zn binding site [ion binding]; other site 573235008624 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 573235008625 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 573235008626 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 573235008627 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 573235008628 signal transduction protein PmrD; Provisional; Region: PRK15450 573235008629 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 573235008630 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 573235008631 acyl-activating enzyme (AAE) consensus motif; other site 573235008632 putative AMP binding site [chemical binding]; other site 573235008633 putative active site [active] 573235008634 putative CoA binding site [chemical binding]; other site 573235008635 O-succinylbenzoate synthase; Provisional; Region: PRK05105 573235008636 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 573235008637 active site 573235008638 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 573235008639 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 573235008640 substrate binding site [chemical binding]; other site 573235008641 oxyanion hole (OAH) forming residues; other site 573235008642 trimer interface [polypeptide binding]; other site 573235008643 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 573235008644 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 573235008645 nucleophilic elbow; other site 573235008646 catalytic triad; other site 573235008647 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 573235008648 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 573235008649 dimer interface [polypeptide binding]; other site 573235008650 tetramer interface [polypeptide binding]; other site 573235008651 PYR/PP interface [polypeptide binding]; other site 573235008652 TPP binding site [chemical binding]; other site 573235008653 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 573235008654 TPP-binding site; other site 573235008655 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 573235008656 isochorismate synthases; Region: isochor_syn; TIGR00543 573235008657 hypothetical protein; Provisional; Region: PRK10404 573235008658 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573235008659 Coenzyme A binding pocket [chemical binding]; other site 573235008660 ribonuclease BN; Region: true_RNase_BN; TIGR02649 573235008661 deubiquitinase; Provisional; Region: PRK11836 573235008662 von Willebrand factor; Region: vWF_A; pfam12450 573235008663 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 573235008664 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 573235008665 metal ion-dependent adhesion site (MIDAS); other site 573235008666 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 573235008667 M28 Zn-Peptidases; Region: M28_like_1; cd05640 573235008668 Peptidase family M28; Region: Peptidase_M28; pfam04389 573235008669 metal binding site [ion binding]; metal-binding site 573235008670 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 573235008671 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 573235008672 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 573235008673 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 573235008674 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 573235008675 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 573235008676 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 573235008677 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 573235008678 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 573235008679 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 573235008680 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 573235008681 4Fe-4S binding domain; Region: Fer4; pfam00037 573235008682 4Fe-4S binding domain; Region: Fer4; pfam00037 573235008683 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 573235008684 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 573235008685 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 573235008686 catalytic loop [active] 573235008687 iron binding site [ion binding]; other site 573235008688 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 573235008689 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 573235008690 [4Fe-4S] binding site [ion binding]; other site 573235008691 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 573235008692 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 573235008693 SLBB domain; Region: SLBB; pfam10531 573235008694 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 573235008695 NADH dehydrogenase subunit E; Validated; Region: PRK07539 573235008696 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 573235008697 putative dimer interface [polypeptide binding]; other site 573235008698 [2Fe-2S] cluster binding site [ion binding]; other site 573235008699 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 573235008700 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 573235008701 NADH dehydrogenase subunit D; Validated; Region: PRK06075 573235008702 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 573235008703 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 573235008704 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 573235008705 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573235008706 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 573235008707 putative dimerization interface [polypeptide binding]; other site 573235008708 aminotransferase AlaT; Validated; Region: PRK09265 573235008709 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573235008710 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573235008711 homodimer interface [polypeptide binding]; other site 573235008712 catalytic residue [active] 573235008713 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573235008714 Zn2+ binding site [ion binding]; other site 573235008715 Mg2+ binding site [ion binding]; other site 573235008716 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 573235008717 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 573235008718 TrkA-C domain; Region: TrkA_C; pfam02080 573235008719 TrkA-C domain; Region: TrkA_C; pfam02080 573235008720 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 573235008721 putative phosphatase; Provisional; Region: PRK11587 573235008722 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573235008723 motif II; other site 573235008724 hypothetical protein; Validated; Region: PRK05445 573235008725 hypothetical protein; Provisional; Region: PRK01816 573235008726 propionate/acetate kinase; Provisional; Region: PRK12379 573235008727 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 573235008728 phosphate acetyltransferase; Reviewed; Region: PRK05632 573235008729 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 573235008730 DRTGG domain; Region: DRTGG; pfam07085 573235008731 phosphate acetyltransferase; Region: pta; TIGR00651 573235008732 hypothetical protein; Provisional; Region: PRK11588 573235008733 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 573235008734 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 573235008735 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 573235008736 nudix motif; other site 573235008737 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 573235008738 active site 573235008739 metal binding site [ion binding]; metal-binding site 573235008740 homotetramer interface [polypeptide binding]; other site 573235008741 glutathione S-transferase; Provisional; Region: PRK15113 573235008742 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 573235008743 C-terminal domain interface [polypeptide binding]; other site 573235008744 GSH binding site (G-site) [chemical binding]; other site 573235008745 dimer interface [polypeptide binding]; other site 573235008746 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 573235008747 N-terminal domain interface [polypeptide binding]; other site 573235008748 putative dimer interface [polypeptide binding]; other site 573235008749 putative substrate binding pocket (H-site) [chemical binding]; other site 573235008750 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 573235008751 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 573235008752 C-terminal domain interface [polypeptide binding]; other site 573235008753 GSH binding site (G-site) [chemical binding]; other site 573235008754 dimer interface [polypeptide binding]; other site 573235008755 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 573235008756 N-terminal domain interface [polypeptide binding]; other site 573235008757 putative dimer interface [polypeptide binding]; other site 573235008758 active site 573235008759 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 573235008760 homooctamer interface [polypeptide binding]; other site 573235008761 active site 573235008762 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 573235008763 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 573235008764 putative NAD(P) binding site [chemical binding]; other site 573235008765 putative active site [active] 573235008766 putative transposase; Provisional; Region: PRK09857 573235008767 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 573235008768 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 573235008769 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 573235008770 Walker A/P-loop; other site 573235008771 ATP binding site [chemical binding]; other site 573235008772 Q-loop/lid; other site 573235008773 ABC transporter signature motif; other site 573235008774 Walker B; other site 573235008775 D-loop; other site 573235008776 H-loop/switch region; other site 573235008777 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573235008778 dimer interface [polypeptide binding]; other site 573235008779 conserved gate region; other site 573235008780 putative PBP binding loops; other site 573235008781 ABC-ATPase subunit interface; other site 573235008782 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 573235008783 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573235008784 dimer interface [polypeptide binding]; other site 573235008785 conserved gate region; other site 573235008786 putative PBP binding loops; other site 573235008787 ABC-ATPase subunit interface; other site 573235008788 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 573235008789 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 573235008790 substrate binding pocket [chemical binding]; other site 573235008791 membrane-bound complex binding site; other site 573235008792 hinge residues; other site 573235008793 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 573235008794 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 573235008795 substrate binding pocket [chemical binding]; other site 573235008796 membrane-bound complex binding site; other site 573235008797 hinge residues; other site 573235008798 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 573235008799 Flavoprotein; Region: Flavoprotein; pfam02441 573235008800 amidophosphoribosyltransferase; Provisional; Region: PRK09246 573235008801 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 573235008802 active site 573235008803 tetramer interface [polypeptide binding]; other site 573235008804 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 573235008805 active site 573235008806 colicin V production protein; Provisional; Region: PRK10845 573235008807 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 573235008808 cell division protein DedD; Provisional; Region: PRK11633 573235008809 Sporulation related domain; Region: SPOR; pfam05036 573235008810 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 573235008811 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 573235008812 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 573235008813 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 573235008814 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 573235008815 hypothetical protein; Provisional; Region: PRK10847 573235008816 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 573235008817 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 573235008818 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 573235008819 dimerization interface 3.5A [polypeptide binding]; other site 573235008820 active site 573235008821 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 573235008822 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 573235008823 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 573235008824 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 573235008825 ligand binding site [chemical binding]; other site 573235008826 NAD binding site [chemical binding]; other site 573235008827 catalytic site [active] 573235008828 homodimer interface [polypeptide binding]; other site 573235008829 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 573235008830 putative transporter; Provisional; Region: PRK12382 573235008831 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235008832 putative substrate translocation pore; other site 573235008833 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 573235008834 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 573235008835 dimer interface [polypeptide binding]; other site 573235008836 active site 573235008837 Uncharacterized conserved protein [Function unknown]; Region: COG4121 573235008838 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 573235008839 YfcL protein; Region: YfcL; pfam08891 573235008840 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 573235008841 hypothetical protein; Provisional; Region: PRK10621 573235008842 Predicted permeases [General function prediction only]; Region: COG0730 573235008843 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 573235008844 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 573235008845 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 573235008846 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 573235008847 Tetramer interface [polypeptide binding]; other site 573235008848 active site 573235008849 FMN-binding site [chemical binding]; other site 573235008850 HemK family putative methylases; Region: hemK_fam; TIGR00536 573235008851 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573235008852 S-adenosylmethionine binding site [chemical binding]; other site 573235008853 hypothetical protein; Provisional; Region: PRK04946 573235008854 Smr domain; Region: Smr; pfam01713 573235008855 Protein of unknown function (DUF2544); Region: DUF2544; pfam11245 573235008856 Fimbrial protein; Region: Fimbrial; cl01416 573235008857 Fimbrial protein; Region: Fimbrial; cl01416 573235008858 Fimbrial protein; Region: Fimbrial; cl01416 573235008859 putative fimbrial chaperone protein StfD; Provisional; Region: PRK15285 573235008860 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 573235008861 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 573235008862 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 573235008863 PapC N-terminal domain; Region: PapC_N; pfam13954 573235008864 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 573235008865 PapC C-terminal domain; Region: PapC_C; pfam13953 573235008866 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 573235008867 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 573235008868 catalytic core [active] 573235008869 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 573235008870 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 573235008871 substrate binding site [chemical binding]; other site 573235008872 oxyanion hole (OAH) forming residues; other site 573235008873 trimer interface [polypeptide binding]; other site 573235008874 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 573235008875 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 573235008876 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 573235008877 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 573235008878 dimer interface [polypeptide binding]; other site 573235008879 active site 573235008880 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 573235008881 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 573235008882 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 573235008883 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 573235008884 Prophage ECO26_P18, P22-like phage 573235008885 integrase; Provisional; Region: PRK09692 573235008886 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 573235008887 active site 573235008888 Int/Topo IB signature motif; other site 573235008889 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 573235008890 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 573235008891 Head binding; Region: Head_binding; pfam09008 573235008892 Right handed beta helix region; Region: Beta_helix; pfam13229 573235008893 Mnt; Region: mnt; PHA01513 573235008894 Arc-like DNA binding domain; Region: Arc; pfam03869 573235008895 Regulatory protein Mnt; Region: Repressor_Mnt; pfam11423 573235008896 Repeats in fly CG4713, worm Y37H9A.3 and human FLJ20241; Region: DM14; smart00685 573235008897 Protein of unknown function (DUF2824); Region: DUF2824; pfam11039 573235008898 Vitamin-D-receptor interacting Mediator subunit 4; Region: Med4; pfam10018 573235008899 Phage stabilisation protein; Region: Phage_stabilise; pfam11134 573235008900 P22 tail accessory factor; Region: P22_Tail-4; pfam11650 573235008901 P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651 573235008902 Phage terminase large subunit; Region: Terminase_3; pfam04466 573235008903 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 573235008904 Protein of unknown function (DUF2560); Region: DUF2560; pfam10834 573235008905 hypothetical protein; Region: PHA01971 573235008906 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646 573235008907 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 573235008908 ORF11CD3 domain; Region: ORF11CD3; pfam10549 573235008909 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 573235008910 Lipoprotein Rz1 precursor; Region: Rz1; pfam06085 573235008911 The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes. But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736 573235008912 N-acetyl-D-glucosamine binding site [chemical binding]; other site 573235008913 catalytic residue [active] 573235008914 phage holin, lambda family; Region: holin_lambda; TIGR01594 573235008915 Antitermination protein; Region: Antiterm; pfam03589 573235008916 Antitermination protein; Region: Antiterm; pfam03589 573235008917 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 573235008918 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 573235008919 active site 573235008920 metal binding site [ion binding]; metal-binding site 573235008921 Phage NinH protein; Region: Phage_NinH; pfam06322 573235008922 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 573235008923 NinB protein; Region: NinB; pfam05772 573235008924 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 573235008925 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 573235008926 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 573235008927 Walker A motif; other site 573235008928 ATP binding site [chemical binding]; other site 573235008929 Walker B motif; other site 573235008930 DNA binding loops [nucleotide binding] 573235008931 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 573235008932 Bacteriophage CII protein; Region: Phage_CII; pfam05269 573235008933 Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197 573235008934 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573235008935 non-specific DNA binding site [nucleotide binding]; other site 573235008936 Predicted transcriptional regulator [Transcription]; Region: COG2932 573235008937 salt bridge; other site 573235008938 sequence-specific DNA binding site [nucleotide binding]; other site 573235008939 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 573235008940 Catalytic site [active] 573235008941 hypothetical protein; Region: PHA01516 573235008942 Prophage ECO26_P18; predicted regulatory protein CIII, C-terminal part 573235008943 Bacteriophage lambda Kil protein; Region: Lambda_Kil; pfam06301 573235008944 ERF superfamily; Region: ERF; pfam04404 573235008945 Protein of unknown function (DUF2856); Region: DUF2856; pfam11043 573235008946 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 573235008947 Protein of unknown function (DUF551); Region: DUF551; pfam04448 573235008948 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 573235008949 Integrative element ECO26_IE04 573235008950 Integrative element ECO26_IE04; predicted integrase, N-terminal part 573235008951 Integrative element ECO26_IE04; predicted integrase, C-terminal part 573235008952 Integrative element ECO26_IE04; predicted transposase OrfB of insertion sequence ISEc16, C-terminal fragment 573235008953 Integrative element ECO26_IE04; predicted transposase OrfB of insertion sequence ISEc16, N-terminal fragment 573235008954 Transposase; Region: HTH_Tnp_1; cl17663 573235008955 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 573235008956 putative transposase OrfB; Reviewed; Region: PHA02517 573235008957 HTH-like domain; Region: HTH_21; pfam13276 573235008958 Integrase core domain; Region: rve; pfam00665 573235008959 Integrase core domain; Region: rve_3; pfam13683 573235008960 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 573235008961 Transposase; Region: HTH_Tnp_1; pfam01527 573235008962 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 573235008963 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573235008964 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 573235008965 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 573235008966 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 573235008967 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573235008968 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 573235008969 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 573235008970 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 573235008971 Integrative element ECO26_IE04; predicted protein Orf3 in insertion sequence ISEc22, C-terminal fragment 573235008972 Domain of unknown function (DUF4365); Region: DUF4365; pfam14280 573235008973 Predicted GTPase [General function prediction only]; Region: COG3596 573235008974 YfjP GTPase; Region: YfjP; cd11383 573235008975 G1 box; other site 573235008976 GTP/Mg2+ binding site [chemical binding]; other site 573235008977 Switch I region; other site 573235008978 G2 box; other site 573235008979 Switch II region; other site 573235008980 G3 box; other site 573235008981 G4 box; other site 573235008982 G5 box; other site 573235008983 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 573235008984 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 573235008985 hypothetical protein; Provisional; Region: PRK09945 573235008986 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 573235008987 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 573235008988 Autotransporter beta-domain; Region: Autotransporter; smart00869 573235008989 Domain of unknown function (DUF932); Region: DUF932; pfam06067 573235008990 Antirestriction protein; Region: Antirestrict; pfam03230 573235008991 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 573235008992 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 573235008993 MPN+ (JAMM) motif; other site 573235008994 Zinc-binding site [ion binding]; other site 573235008995 Protein of unknown function (DUF987); Region: DUF987; pfam06174 573235008996 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 573235008997 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 573235008998 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235008999 putative substrate translocation pore; other site 573235009000 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 573235009001 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 573235009002 putative substrate binding site [chemical binding]; other site 573235009003 putative ATP binding site [chemical binding]; other site 573235009004 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 573235009005 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 573235009006 substrate binding [chemical binding]; other site 573235009007 active site 573235009008 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 573235009009 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573235009010 DNA binding site [nucleotide binding] 573235009011 domain linker motif; other site 573235009012 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 573235009013 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 573235009014 putative dimerization interface [polypeptide binding]; other site 573235009015 putative ligand binding site [chemical binding]; other site 573235009016 transport protein, C-terminal fragment 573235009017 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 573235009018 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 573235009019 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 573235009020 catalytic residue [active] 573235009021 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 573235009022 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235009023 putative substrate translocation pore; other site 573235009024 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235009025 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 573235009026 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 573235009027 HlyD family secretion protein; Region: HlyD_3; pfam13437 573235009028 DNA-binding transcriptional activator EvgA; Provisional; Region: PRK09958 573235009029 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573235009030 active site 573235009031 phosphorylation site [posttranslational modification] 573235009032 intermolecular recognition site; other site 573235009033 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573235009034 DNA binding residues [nucleotide binding] 573235009035 dimerization interface [polypeptide binding]; other site 573235009036 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 573235009037 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 573235009038 substrate binding pocket [chemical binding]; other site 573235009039 membrane-bound complex binding site; other site 573235009040 hinge residues; other site 573235009041 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 573235009042 substrate binding pocket [chemical binding]; other site 573235009043 membrane-bound complex binding site; other site 573235009044 hinge residues; other site 573235009045 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573235009046 dimer interface [polypeptide binding]; other site 573235009047 phosphorylation site [posttranslational modification] 573235009048 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573235009049 ATP binding site [chemical binding]; other site 573235009050 Mg2+ binding site [ion binding]; other site 573235009051 G-X-G motif; other site 573235009052 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573235009053 active site 573235009054 phosphorylation site [posttranslational modification] 573235009055 intermolecular recognition site; other site 573235009056 dimerization interface [polypeptide binding]; other site 573235009057 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 573235009058 putative binding surface; other site 573235009059 active site 573235009060 putative CoA-transferase; Provisional; Region: PRK11430 573235009061 CoA-transferase family III; Region: CoA_transf_3; pfam02515 573235009062 putative transporter YfdV; Provisional; Region: PRK09903 573235009063 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 573235009064 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 573235009065 PYR/PP interface [polypeptide binding]; other site 573235009066 dimer interface [polypeptide binding]; other site 573235009067 TPP binding site [chemical binding]; other site 573235009068 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 573235009069 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 573235009070 TPP-binding site; other site 573235009071 dimer interface [polypeptide binding]; other site 573235009072 formyl-coenzyme A transferase; Provisional; Region: PRK05398 573235009073 CoA-transferase family III; Region: CoA_transf_3; pfam02515 573235009074 hypothetical protein; Provisional; Region: PRK10316 573235009075 YfdX protein; Region: YfdX; pfam10938 573235009076 Protein of unknown function (DUF2545); Region: DUF2545; pfam10810 573235009077 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 573235009078 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 573235009079 putative acyl-acceptor binding pocket; other site 573235009080 aminotransferase; Validated; Region: PRK08175 573235009081 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573235009082 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573235009083 homodimer interface [polypeptide binding]; other site 573235009084 catalytic residue [active] 573235009085 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 573235009086 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 573235009087 GAF domain; Region: GAF; pfam01590 573235009088 Histidine kinase; Region: His_kinase; pfam06580 573235009089 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573235009090 ATP binding site [chemical binding]; other site 573235009091 Mg2+ binding site [ion binding]; other site 573235009092 G-X-G motif; other site 573235009093 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 573235009094 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573235009095 active site 573235009096 phosphorylation site [posttranslational modification] 573235009097 intermolecular recognition site; other site 573235009098 dimerization interface [polypeptide binding]; other site 573235009099 LytTr DNA-binding domain; Region: LytTR; pfam04397 573235009100 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 573235009101 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573235009102 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 573235009103 dimerization domain swap beta strand [polypeptide binding]; other site 573235009104 regulatory protein interface [polypeptide binding]; other site 573235009105 active site 573235009106 regulatory phosphorylation site [posttranslational modification]; other site 573235009107 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 573235009108 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 573235009109 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 573235009110 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 573235009111 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 573235009112 active site 573235009113 phosphorylation site [posttranslational modification] 573235009114 exoaminopeptidase; Provisional; Region: PRK09961 573235009115 M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638 573235009116 oligomer interface [polypeptide binding]; other site 573235009117 active site 573235009118 metal binding site [ion binding]; metal-binding site 573235009119 aminopeptidase; Provisional; Region: PRK09795 573235009120 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 573235009121 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 573235009122 active site 573235009123 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 573235009124 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 573235009125 active site 573235009126 P-loop; other site 573235009127 phosphorylation site [posttranslational modification] 573235009128 glucokinase, proteobacterial type; Region: glk; TIGR00749 573235009129 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 573235009130 nucleotide binding site [chemical binding]; other site 573235009131 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 573235009132 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 573235009133 Cl- selectivity filter; other site 573235009134 Cl- binding residues [ion binding]; other site 573235009135 pore gating glutamate residue; other site 573235009136 dimer interface [polypeptide binding]; other site 573235009137 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 573235009138 manganese transport protein MntH; Reviewed; Region: PRK00701 573235009139 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 573235009140 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 573235009141 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 573235009142 Nucleoside recognition; Region: Gate; pfam07670 573235009143 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 573235009144 MASE1; Region: MASE1; pfam05231 573235009145 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 573235009146 diguanylate cyclase; Region: GGDEF; smart00267 573235009147 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 573235009148 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 573235009149 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573235009150 salt bridge; other site 573235009151 non-specific DNA binding site [nucleotide binding]; other site 573235009152 sequence-specific DNA binding site [nucleotide binding]; other site 573235009153 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 573235009154 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 573235009155 active site 573235009156 HIGH motif; other site 573235009157 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 573235009158 active site 573235009159 KMSKS motif; other site 573235009160 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 573235009161 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573235009162 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 573235009163 putative dimerization interface [polypeptide binding]; other site 573235009164 putative substrate binding pocket [chemical binding]; other site 573235009165 nucleoside transporter; Region: 2A0110; TIGR00889 573235009166 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235009167 putative substrate translocation pore; other site 573235009168 purine nucleoside phosphorylase; Provisional; Region: PRK08202 573235009169 hypothetical protein; Provisional; Region: PRK11528 573235009170 Transcriptional regulator [Transcription]; Region: LysR; COG0583 573235009171 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573235009172 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 573235009173 putative dimerization interface [polypeptide binding]; other site 573235009174 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 573235009175 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 573235009176 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 573235009177 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 573235009178 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 573235009179 nucleotide binding pocket [chemical binding]; other site 573235009180 K-X-D-G motif; other site 573235009181 catalytic site [active] 573235009182 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 573235009183 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 573235009184 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 573235009185 Dimer interface [polypeptide binding]; other site 573235009186 BRCT sequence motif; other site 573235009187 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 573235009188 cell division protein ZipA; Provisional; Region: PRK03427 573235009189 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 573235009190 FtsZ protein binding site [polypeptide binding]; other site 573235009191 putative sulfate transport protein CysZ; Validated; Region: PRK04949 573235009192 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 573235009193 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 573235009194 dimer interface [polypeptide binding]; other site 573235009195 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573235009196 catalytic residue [active] 573235009197 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 573235009198 dimerization domain swap beta strand [polypeptide binding]; other site 573235009199 regulatory protein interface [polypeptide binding]; other site 573235009200 active site 573235009201 regulatory phosphorylation site [posttranslational modification]; other site 573235009202 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 573235009203 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 573235009204 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 573235009205 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 573235009206 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 573235009207 HPr interaction site; other site 573235009208 glycerol kinase (GK) interaction site [polypeptide binding]; other site 573235009209 active site 573235009210 phosphorylation site [posttranslational modification] 573235009211 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 573235009212 dimer interface [polypeptide binding]; other site 573235009213 pyridoxamine kinase; Validated; Region: PRK05756 573235009214 pyridoxal binding site [chemical binding]; other site 573235009215 ATP binding site [chemical binding]; other site 573235009216 hypothetical protein; Provisional; Region: PRK10318 573235009217 cysteine synthase B; Region: cysM; TIGR01138 573235009218 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 573235009219 dimer interface [polypeptide binding]; other site 573235009220 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573235009221 catalytic residue [active] 573235009222 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 573235009223 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 573235009224 Walker A/P-loop; other site 573235009225 ATP binding site [chemical binding]; other site 573235009226 Q-loop/lid; other site 573235009227 ABC transporter signature motif; other site 573235009228 Walker B; other site 573235009229 D-loop; other site 573235009230 H-loop/switch region; other site 573235009231 TOBE-like domain; Region: TOBE_3; pfam12857 573235009232 sulfate transport protein; Provisional; Region: cysT; CHL00187 573235009233 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573235009234 dimer interface [polypeptide binding]; other site 573235009235 conserved gate region; other site 573235009236 putative PBP binding loops; other site 573235009237 ABC-ATPase subunit interface; other site 573235009238 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 573235009239 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573235009240 dimer interface [polypeptide binding]; other site 573235009241 conserved gate region; other site 573235009242 putative PBP binding loops; other site 573235009243 ABC-ATPase subunit interface; other site 573235009244 thiosulfate transporter subunit; Provisional; Region: PRK10852 573235009245 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 573235009246 short chain dehydrogenase; Provisional; Region: PRK08226 573235009247 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 573235009248 NAD binding site [chemical binding]; other site 573235009249 homotetramer interface [polypeptide binding]; other site 573235009250 homodimer interface [polypeptide binding]; other site 573235009251 active site 573235009252 transcriptional regulator MurR; Provisional; Region: PRK15482 573235009253 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 573235009254 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 573235009255 putative active site [active] 573235009256 N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274 573235009257 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 573235009258 putative active site [active] 573235009259 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 573235009260 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 573235009261 active site turn [active] 573235009262 phosphorylation site [posttranslational modification] 573235009263 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 573235009264 putative periplasmic esterase; Provisional; Region: PRK03642 573235009265 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 573235009266 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 573235009267 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 573235009268 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 573235009269 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 573235009270 putative acetyltransferase; Provisional; Region: PRK03624 573235009271 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573235009272 Coenzyme A binding pocket [chemical binding]; other site 573235009273 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 573235009274 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 573235009275 active site 573235009276 metal binding site [ion binding]; metal-binding site 573235009277 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 573235009278 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 573235009279 transcriptional regulator EutR; Provisional; Region: PRK10130 573235009280 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573235009281 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573235009282 carboxysome structural protein EutK; Provisional; Region: PRK15466 573235009283 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 573235009284 Hexamer interface [polypeptide binding]; other site 573235009285 Hexagonal pore residue; other site 573235009286 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 573235009287 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 573235009288 putative hexamer interface [polypeptide binding]; other site 573235009289 putative hexagonal pore; other site 573235009290 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 573235009291 putative hexamer interface [polypeptide binding]; other site 573235009292 putative hexagonal pore; other site 573235009293 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 573235009294 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 573235009295 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 573235009296 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 573235009297 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 573235009298 ethanol dehydrogenase EutG; Provisional; Region: PRK15454 573235009299 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 573235009300 active site 573235009301 metal binding site [ion binding]; metal-binding site 573235009302 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 573235009303 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 573235009304 nucleotide binding site [chemical binding]; other site 573235009305 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 573235009306 putative catalytic cysteine [active] 573235009307 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 573235009308 Hexamer/Pentamer interface [polypeptide binding]; other site 573235009309 central pore; other site 573235009310 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 573235009311 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 573235009312 Hexamer interface [polypeptide binding]; other site 573235009313 Putative hexagonal pore residue; other site 573235009314 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 573235009315 ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020 573235009316 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 573235009317 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766 573235009318 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 573235009319 G1 box; other site 573235009320 GTP/Mg2+ binding site [chemical binding]; other site 573235009321 G2 box; other site 573235009322 Switch I region; other site 573235009323 G3 box; other site 573235009324 Switch II region; other site 573235009325 G4 box; other site 573235009326 G5 box; other site 573235009327 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 573235009328 putative hexamer interface [polypeptide binding]; other site 573235009329 putative hexagonal pore; other site 573235009330 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 573235009331 Malic enzyme, N-terminal domain; Region: malic; pfam00390 573235009332 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 573235009333 putative NAD(P) binding site [chemical binding]; other site 573235009334 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 573235009335 transaldolase-like protein; Provisional; Region: PTZ00411 573235009336 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 573235009337 active site 573235009338 dimer interface [polypeptide binding]; other site 573235009339 catalytic residue [active] 573235009340 transketolase; Reviewed; Region: PRK12753 573235009341 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 573235009342 TPP-binding site [chemical binding]; other site 573235009343 dimer interface [polypeptide binding]; other site 573235009344 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 573235009345 PYR/PP interface [polypeptide binding]; other site 573235009346 dimer interface [polypeptide binding]; other site 573235009347 TPP binding site [chemical binding]; other site 573235009348 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 573235009349 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 573235009350 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 573235009351 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 573235009352 dimer interface [polypeptide binding]; other site 573235009353 ADP-ribose binding site [chemical binding]; other site 573235009354 active site 573235009355 nudix motif; other site 573235009356 metal binding site [ion binding]; metal-binding site 573235009357 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 573235009358 4Fe-4S binding domain; Region: Fer4; pfam00037 573235009359 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 573235009360 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 573235009361 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 573235009362 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 573235009363 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573235009364 dimerization interface [polypeptide binding]; other site 573235009365 Histidine kinase; Region: HisKA_3; pfam07730 573235009366 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573235009367 ATP binding site [chemical binding]; other site 573235009368 Mg2+ binding site [ion binding]; other site 573235009369 G-X-G motif; other site 573235009370 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 573235009371 Protein export membrane protein; Region: SecD_SecF; cl14618 573235009372 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 573235009373 ArsC family; Region: ArsC; pfam03960 573235009374 putative catalytic residues [active] 573235009375 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 573235009376 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 573235009377 metal binding site [ion binding]; metal-binding site 573235009378 dimer interface [polypeptide binding]; other site 573235009379 hypothetical protein; Provisional; Region: PRK13664 573235009380 putative hydrolase; Provisional; Region: PRK11460 573235009381 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 573235009382 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 573235009383 Helicase; Region: Helicase_RecD; pfam05127 573235009384 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 573235009385 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 573235009386 Predicted metalloprotease [General function prediction only]; Region: COG2321 573235009387 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 573235009388 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 573235009389 oligomeric interface; other site 573235009390 putative active site [active] 573235009391 homodimer interface [polypeptide binding]; other site 573235009392 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 573235009393 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 573235009394 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 573235009395 ATP binding site [chemical binding]; other site 573235009396 active site 573235009397 substrate binding site [chemical binding]; other site 573235009398 lipoprotein; Provisional; Region: PRK11679 573235009399 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 573235009400 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 573235009401 dihydrodipicolinate synthase; Region: dapA; TIGR00674 573235009402 dimer interface [polypeptide binding]; other site 573235009403 active site 573235009404 catalytic residue [active] 573235009405 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 573235009406 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 573235009407 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 573235009408 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 573235009409 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 573235009410 catalytic triad [active] 573235009411 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 573235009412 4Fe-4S binding domain; Region: Fer4; pfam00037 573235009413 hydrogenase 4 subunit B; Validated; Region: PRK06521 573235009414 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 573235009415 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 573235009416 NADH dehydrogenase; Region: NADHdh; cl00469 573235009417 hydrogenase 4 subunit D; Validated; Region: PRK06525 573235009418 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 573235009419 hydrogenase 4 membrane subunit; Provisional; Region: hyfE; PRK11492 573235009420 hydrogenase 4 subunit F; Validated; Region: PRK06458 573235009421 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 573235009422 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 573235009423 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 573235009424 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 573235009425 hydrogenase 4 subunit H; Validated; Region: PRK08222 573235009426 4Fe-4S binding domain; Region: Fer4; pfam00037 573235009427 hydrogenase 4, Fe-S subunit HyfI, N-terminal fragment 573235009428 hydrogenase 4, Fe-S subunit HyfI, C-terminal fragment 573235009429 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 573235009430 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 573235009431 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 573235009432 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573235009433 Walker A motif; other site 573235009434 ATP binding site [chemical binding]; other site 573235009435 Walker B motif; other site 573235009436 arginine finger; other site 573235009437 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 573235009438 putative formate transporter; Provisional; Region: focB; PRK09713 573235009439 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 573235009440 Domain of unknown function DUF20; Region: UPF0118; pfam01594 573235009441 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 573235009442 Peptidase family M48; Region: Peptidase_M48; cl12018 573235009443 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 573235009444 ArsC family; Region: ArsC; pfam03960 573235009445 catalytic residues [active] 573235009446 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 573235009447 DNA replication initiation factor; Provisional; Region: PRK08084 573235009448 uracil transporter; Provisional; Region: PRK10720 573235009449 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 573235009450 active site 573235009451 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 573235009452 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 573235009453 dimerization interface [polypeptide binding]; other site 573235009454 putative ATP binding site [chemical binding]; other site 573235009455 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 573235009456 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 573235009457 active site 573235009458 substrate binding site [chemical binding]; other site 573235009459 cosubstrate binding site; other site 573235009460 catalytic site [active] 573235009461 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 573235009462 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 573235009463 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 573235009464 Catalytic C-terminal domain, first repeat, of prokaryotic polyphosphate kinase 1 and similar proteins; Region: PLDc_PPK1_C1; cd09114 573235009465 domain interface [polypeptide binding]; other site 573235009466 active site 573235009467 catalytic site [active] 573235009468 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 573235009469 putative active site [active] 573235009470 catalytic site [active] 573235009471 exopolyphosphatase; Provisional; Region: PRK10854 573235009472 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 573235009473 MASE1; Region: MASE1; pfam05231 573235009474 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 573235009475 diguanylate cyclase; Region: GGDEF; smart00267 573235009476 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 573235009477 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 573235009478 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 573235009479 GMP synthase; Reviewed; Region: guaA; PRK00074 573235009480 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 573235009481 AMP/PPi binding site [chemical binding]; other site 573235009482 candidate oxyanion hole; other site 573235009483 catalytic triad [active] 573235009484 potential glutamine specificity residues [chemical binding]; other site 573235009485 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 573235009486 ATP Binding subdomain [chemical binding]; other site 573235009487 Ligand Binding sites [chemical binding]; other site 573235009488 Dimerization subdomain; other site 573235009489 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 573235009490 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 573235009491 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 573235009492 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 573235009493 active site 573235009494 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 573235009495 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 573235009496 generic binding surface II; other site 573235009497 generic binding surface I; other site 573235009498 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 573235009499 GTP-binding protein Der; Reviewed; Region: PRK00093 573235009500 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 573235009501 G1 box; other site 573235009502 GTP/Mg2+ binding site [chemical binding]; other site 573235009503 Switch I region; other site 573235009504 G2 box; other site 573235009505 Switch II region; other site 573235009506 G3 box; other site 573235009507 G4 box; other site 573235009508 G5 box; other site 573235009509 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 573235009510 G1 box; other site 573235009511 GTP/Mg2+ binding site [chemical binding]; other site 573235009512 Switch I region; other site 573235009513 G2 box; other site 573235009514 G3 box; other site 573235009515 Switch II region; other site 573235009516 G4 box; other site 573235009517 G5 box; other site 573235009518 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 573235009519 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cd00216 573235009520 Trp docking motif [polypeptide binding]; other site 573235009521 active site 573235009522 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 573235009523 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 573235009524 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 573235009525 dimer interface [polypeptide binding]; other site 573235009526 motif 1; other site 573235009527 active site 573235009528 motif 2; other site 573235009529 motif 3; other site 573235009530 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 573235009531 anticodon binding site; other site 573235009532 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 573235009533 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 573235009534 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 573235009535 cytoskeletal protein RodZ; Provisional; Region: PRK10856 573235009536 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573235009537 non-specific DNA binding site [nucleotide binding]; other site 573235009538 salt bridge; other site 573235009539 sequence-specific DNA binding site [nucleotide binding]; other site 573235009540 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 573235009541 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 573235009542 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573235009543 FeS/SAM binding site; other site 573235009544 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 573235009545 active site 573235009546 multimer interface [polypeptide binding]; other site 573235009547 penicillin-binding protein 1C; Provisional; Region: PRK11240 573235009548 Transglycosylase; Region: Transgly; pfam00912 573235009549 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 573235009550 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 573235009551 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 573235009552 MG2 domain; Region: A2M_N; pfam01835 573235009553 Alpha-2-macroglobulin family; Region: A2M; pfam00207 573235009554 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 573235009555 surface patch; other site 573235009556 thioester region; other site 573235009557 specificity defining residues; other site 573235009558 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 573235009559 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 573235009560 active site residue [active] 573235009561 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 573235009562 active site residue [active] 573235009563 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 573235009564 aminopeptidase B; Provisional; Region: PRK05015 573235009565 Peptidase; Region: DUF3663; pfam12404 573235009566 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 573235009567 interface (dimer of trimers) [polypeptide binding]; other site 573235009568 Substrate-binding/catalytic site; other site 573235009569 Zn-binding sites [ion binding]; other site 573235009570 hypothetical protein; Provisional; Region: PRK10721 573235009571 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 573235009572 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 573235009573 catalytic loop [active] 573235009574 iron binding site [ion binding]; other site 573235009575 chaperone protein HscA; Provisional; Region: hscA; PRK05183 573235009576 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 573235009577 nucleotide binding site [chemical binding]; other site 573235009578 putative NEF/HSP70 interaction site [polypeptide binding]; other site 573235009579 SBD interface [polypeptide binding]; other site 573235009580 co-chaperone HscB; Provisional; Region: hscB; PRK05014 573235009581 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 573235009582 HSP70 interaction site [polypeptide binding]; other site 573235009583 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 573235009584 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 573235009585 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 573235009586 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 573235009587 trimerization site [polypeptide binding]; other site 573235009588 active site 573235009589 cysteine desulfurase; Provisional; Region: PRK14012 573235009590 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 573235009591 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 573235009592 catalytic residue [active] 573235009593 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 573235009594 Rrf2 family protein; Region: rrf2_super; TIGR00738 573235009595 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 573235009596 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 573235009597 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 573235009598 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 573235009599 active site 573235009600 dimerization interface [polypeptide binding]; other site 573235009601 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 573235009602 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 573235009603 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 573235009604 PRD domain; Region: PRD; pfam00874 573235009605 PRD domain; Region: PRD; pfam00874 573235009606 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 573235009607 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235009608 putative substrate translocation pore; other site 573235009609 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 573235009610 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573235009611 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 573235009612 dimerization interface [polypeptide binding]; other site 573235009613 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 573235009614 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 573235009615 iron-sulfur cluster [ion binding]; other site 573235009616 [2Fe-2S] cluster binding site [ion binding]; other site 573235009617 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 573235009618 beta subunit interface [polypeptide binding]; other site 573235009619 alpha subunit interface [polypeptide binding]; other site 573235009620 active site 573235009621 substrate binding site [chemical binding]; other site 573235009622 Fe binding site [ion binding]; other site 573235009623 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 573235009624 inter-subunit interface; other site 573235009625 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 573235009626 [2Fe-2S] cluster binding site [ion binding]; other site 573235009627 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 573235009628 cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase (BphB)-like, classical (c) SDRs; Region: BphB-like_SDR_c; cd05348 573235009629 NAD binding site [chemical binding]; other site 573235009630 active site 573235009631 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 573235009632 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 573235009633 Predicted membrane protein [Function unknown]; Region: COG2259 573235009634 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 573235009635 active site 573235009636 catalytic residues [active] 573235009637 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 573235009638 L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239 573235009639 putative NAD(P) binding site [chemical binding]; other site 573235009640 catalytic Zn binding site [ion binding]; other site 573235009641 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573235009642 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 573235009643 TM-ABC transporter signature motif; other site 573235009644 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 573235009645 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 573235009646 Walker A/P-loop; other site 573235009647 ATP binding site [chemical binding]; other site 573235009648 Q-loop/lid; other site 573235009649 ABC transporter signature motif; other site 573235009650 Walker B; other site 573235009651 D-loop; other site 573235009652 H-loop/switch region; other site 573235009653 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 573235009654 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 573235009655 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 573235009656 ligand binding site [chemical binding]; other site 573235009657 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573235009658 TPR motif; other site 573235009659 Tetratricopeptide repeat; Region: TPR_16; pfam13432 573235009660 binding surface 573235009661 TPR repeat; Region: TPR_11; pfam13414 573235009662 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573235009663 TPR motif; other site 573235009664 binding surface 573235009665 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 573235009666 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 573235009667 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 573235009668 nucleotide binding site [chemical binding]; other site 573235009669 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 573235009670 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 573235009671 dimer interface [polypeptide binding]; other site 573235009672 active site 573235009673 glycine-pyridoxal phosphate binding site [chemical binding]; other site 573235009674 folate binding site [chemical binding]; other site 573235009675 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 573235009676 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 573235009677 heme-binding site [chemical binding]; other site 573235009678 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 573235009679 FAD binding pocket [chemical binding]; other site 573235009680 FAD binding motif [chemical binding]; other site 573235009681 phosphate binding motif [ion binding]; other site 573235009682 beta-alpha-beta structure motif; other site 573235009683 NAD binding pocket [chemical binding]; other site 573235009684 Heme binding pocket [chemical binding]; other site 573235009685 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 573235009686 Nitrogen regulatory protein P-II; Region: P-II; smart00938 573235009687 response regulator GlrR; Provisional; Region: PRK15115 573235009688 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573235009689 active site 573235009690 phosphorylation site [posttranslational modification] 573235009691 intermolecular recognition site; other site 573235009692 dimerization interface [polypeptide binding]; other site 573235009693 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573235009694 Walker A motif; other site 573235009695 ATP binding site [chemical binding]; other site 573235009696 Walker B motif; other site 573235009697 arginine finger; other site 573235009698 hypothetical protein; Provisional; Region: PRK10722 573235009699 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573235009700 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573235009701 dimer interface [polypeptide binding]; other site 573235009702 phosphorylation site [posttranslational modification] 573235009703 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573235009704 ATP binding site [chemical binding]; other site 573235009705 Mg2+ binding site [ion binding]; other site 573235009706 G-X-G motif; other site 573235009707 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 573235009708 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 573235009709 dimerization interface [polypeptide binding]; other site 573235009710 ATP binding site [chemical binding]; other site 573235009711 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 573235009712 dimerization interface [polypeptide binding]; other site 573235009713 ATP binding site [chemical binding]; other site 573235009714 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 573235009715 putative active site [active] 573235009716 catalytic triad [active] 573235009717 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 573235009718 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 573235009719 substrate binding pocket [chemical binding]; other site 573235009720 membrane-bound complex binding site; other site 573235009721 hinge residues; other site 573235009722 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 573235009723 N-acetyl-D-glucosamine binding site [chemical binding]; other site 573235009724 catalytic residue [active] 573235009725 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 573235009726 nucleoside/Zn binding site; other site 573235009727 dimer interface [polypeptide binding]; other site 573235009728 catalytic motif [active] 573235009729 hypothetical protein; Provisional; Region: PRK11590 573235009730 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 573235009731 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 573235009732 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 573235009733 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 573235009734 putative active site [active] 573235009735 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 573235009736 holo-[acyl-carrier-protein] synthase; Region: acpS; TIGR00516 573235009737 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 573235009738 active site 573235009739 hydrophilic channel; other site 573235009740 dimerization interface [polypeptide binding]; other site 573235009741 catalytic residues [active] 573235009742 active site lid [active] 573235009743 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 573235009744 Recombination protein O N terminal; Region: RecO_N; pfam11967 573235009745 Recombination protein O C terminal; Region: RecO_C; pfam02565 573235009746 GTPase Era; Reviewed; Region: era; PRK00089 573235009747 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 573235009748 G1 box; other site 573235009749 GTP/Mg2+ binding site [chemical binding]; other site 573235009750 Switch I region; other site 573235009751 G2 box; other site 573235009752 Switch II region; other site 573235009753 G3 box; other site 573235009754 G4 box; other site 573235009755 G5 box; other site 573235009756 KH domain; Region: KH_2; pfam07650 573235009757 ribonuclease III; Reviewed; Region: rnc; PRK00102 573235009758 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 573235009759 dimerization interface [polypeptide binding]; other site 573235009760 active site 573235009761 metal binding site [ion binding]; metal-binding site 573235009762 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 573235009763 dsRNA binding site [nucleotide binding]; other site 573235009764 signal peptidase I; Provisional; Region: PRK10861 573235009765 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 573235009766 Catalytic site [active] 573235009767 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 573235009768 GTP-binding protein LepA; Provisional; Region: PRK05433 573235009769 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 573235009770 G1 box; other site 573235009771 putative GEF interaction site [polypeptide binding]; other site 573235009772 GTP/Mg2+ binding site [chemical binding]; other site 573235009773 Switch I region; other site 573235009774 G2 box; other site 573235009775 G3 box; other site 573235009776 Switch II region; other site 573235009777 G4 box; other site 573235009778 G5 box; other site 573235009779 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 573235009780 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 573235009781 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 573235009782 SoxR reducing system protein RseC; Provisional; Region: PRK10862 573235009783 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 573235009784 anti-sigma E factor; Provisional; Region: rseB; PRK09455 573235009785 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 573235009786 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 573235009787 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 573235009788 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 573235009789 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573235009790 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573235009791 DNA binding residues [nucleotide binding] 573235009792 L-aspartate oxidase; Provisional; Region: PRK09077 573235009793 L-aspartate oxidase; Provisional; Region: PRK06175 573235009794 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 573235009795 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 573235009796 Methyltransferase domain; Region: Methyltransf_26; pfam13659 573235009797 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 573235009798 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 573235009799 ATP binding site [chemical binding]; other site 573235009800 Mg++ binding site [ion binding]; other site 573235009801 motif III; other site 573235009802 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573235009803 nucleotide binding region [chemical binding]; other site 573235009804 ATP-binding site [chemical binding]; other site 573235009805 Transcriptional regulator [Transcription]; Region: LysR; COG0583 573235009806 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573235009807 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 573235009808 dimerization interface [polypeptide binding]; other site 573235009809 cysteine/O-acetylserine exporter; Provisional; Region: PRK10323 573235009810 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 573235009811 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 573235009812 ligand binding site [chemical binding]; other site 573235009813 active site 573235009814 UGI interface [polypeptide binding]; other site 573235009815 catalytic site [active] 573235009816 putative methyltransferase; Provisional; Region: PRK10864 573235009817 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 573235009818 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 573235009819 thioredoxin 2; Provisional; Region: PRK10996 573235009820 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 573235009821 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 573235009822 catalytic residues [active] 573235009823 Uncharacterized conserved protein [Function unknown]; Region: COG3148 573235009824 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 573235009825 CoA binding domain; Region: CoA_binding_2; pfam13380 573235009826 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 573235009827 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 573235009828 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 573235009829 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 573235009830 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 573235009831 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 573235009832 domain interface [polypeptide binding]; other site 573235009833 putative active site [active] 573235009834 catalytic site [active] 573235009835 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 573235009836 domain interface [polypeptide binding]; other site 573235009837 putative active site [active] 573235009838 catalytic site [active] 573235009839 lipoprotein; Provisional; Region: PRK10759 573235009840 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 573235009841 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235009842 putative substrate translocation pore; other site 573235009843 protein disaggregation chaperone; Provisional; Region: PRK10865 573235009844 Clp amino terminal domain; Region: Clp_N; pfam02861 573235009845 Clp amino terminal domain; Region: Clp_N; pfam02861 573235009846 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573235009847 Walker A motif; other site 573235009848 ATP binding site [chemical binding]; other site 573235009849 Walker B motif; other site 573235009850 arginine finger; other site 573235009851 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573235009852 Walker A motif; other site 573235009853 ATP binding site [chemical binding]; other site 573235009854 Walker B motif; other site 573235009855 arginine finger; other site 573235009856 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 573235009857 hypothetical protein; Provisional; Region: PRK10723 573235009858 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 573235009859 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 573235009860 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 573235009861 RNA binding surface [nucleotide binding]; other site 573235009862 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 573235009863 active site 573235009864 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 573235009865 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 573235009866 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 573235009867 30S subunit binding site; other site 573235009868 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 573235009869 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 573235009870 Prephenate dehydratase; Region: PDT; pfam00800 573235009871 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 573235009872 putative L-Phe binding site [chemical binding]; other site 573235009873 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 573235009874 chorismate mutase domain of T-protein; Region: CM_T; TIGR01799 573235009875 prephenate dehydrogenase; Validated; Region: PRK08507 573235009876 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 573235009877 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 573235009878 lipoprotein; Provisional; Region: PRK11443 573235009879 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 573235009880 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 573235009881 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 573235009882 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573235009883 metal binding site [ion binding]; metal-binding site 573235009884 active site 573235009885 I-site; other site 573235009886 putative outer membrane lipoprotein; Provisional; Region: PRK09967 573235009887 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 573235009888 ligand binding site [chemical binding]; other site 573235009889 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 573235009890 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 573235009891 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 573235009892 RimM N-terminal domain; Region: RimM; pfam01782 573235009893 PRC-barrel domain; Region: PRC; pfam05239 573235009894 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 573235009895 signal recognition particle protein; Provisional; Region: PRK10867 573235009896 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 573235009897 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 573235009898 P loop; other site 573235009899 GTP binding site [chemical binding]; other site 573235009900 Signal peptide binding domain; Region: SRP_SPB; pfam02978 573235009901 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 573235009902 hypothetical protein; Provisional; Region: PRK11573 573235009903 Domain of unknown function DUF21; Region: DUF21; pfam01595 573235009904 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 573235009905 Transporter associated domain; Region: CorC_HlyC; smart01091 573235009906 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 573235009907 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 573235009908 dimer interface [polypeptide binding]; other site 573235009909 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 573235009910 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 573235009911 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 573235009912 recombination and repair protein; Provisional; Region: PRK10869 573235009913 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 573235009914 Walker A/P-loop; other site 573235009915 ATP binding site [chemical binding]; other site 573235009916 Q-loop/lid; other site 573235009917 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 573235009918 Q-loop/lid; other site 573235009919 ABC transporter signature motif; other site 573235009920 Walker B; other site 573235009921 D-loop; other site 573235009922 H-loop/switch region; other site 573235009923 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 573235009924 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 573235009925 hypothetical protein; Validated; Region: PRK01777 573235009926 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 573235009927 putative coenzyme Q binding site [chemical binding]; other site 573235009928 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 573235009929 SmpB-tmRNA interface; other site 573235009930 Prophage ECO26_P19, lambda-like phage 573235009931 Prophage ECO26_P19; predicted DNA damage-inducible protein, C-terminal part 573235009932 type III secretion protein GogB; Provisional; Region: PRK15386 573235009933 E3 ubiquitin-protein ligase SopA; Provisional; Region: PRK15377 573235009934 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 573235009935 SopA-like central domain; Region: SopA; pfam13981 573235009936 SopA-like catalytic domain; Region: SopA_C; pfam13979 573235009937 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 573235009938 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 573235009939 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 573235009940 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 573235009941 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 573235009942 Phage-related protein, tail component [Function unknown]; Region: COG4733 573235009943 Putative phage tail protein; Region: Phage-tail_3; pfam13550 573235009944 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 573235009945 Interdomain contacts; other site 573235009946 Cytokine receptor motif; other site 573235009947 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 573235009948 Fibronectin type III protein; Region: DUF3672; pfam12421 573235009949 Phage-related protein, tail component [Function unknown]; Region: COG4723 573235009950 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 573235009951 MPN+ (JAMM) motif; other site 573235009952 Zinc-binding site [ion binding]; other site 573235009953 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 573235009954 NlpC/P60 family; Region: NLPC_P60; cl17555 573235009955 Phage-related protein [Function unknown]; Region: gp18; COG4672 573235009956 Phage-related protein [Function unknown]; Region: COG4718 573235009957 Phage-related minor tail protein [Function unknown]; Region: COG5281 573235009958 tape measure domain; Region: tape_meas_nterm; TIGR02675 573235009959 Tail length tape measure protein; Region: Phage_HK97_TLTM; pfam06120 573235009960 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 573235009961 Protein of unknown function (DUF4035); Region: DUF4035; pfam13227 573235009962 Phage tail assembly chaperone; Region: Phage_TAC; pfam06222 573235009963 Immunoglobulin I-set domain; Region: I-set; pfam07679 573235009964 Immunoglobulin domain; Region: Ig_2; pfam13895 573235009965 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 573235009966 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 573235009967 Bacteriophage head-tail adaptor [General function prediction only]; Region: COG5614 573235009968 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 573235009969 Phage-related protein [Function unknown]; Region: COG4695 573235009970 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 573235009971 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 573235009972 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 573235009973 Phage capsid family; Region: Phage_capsid; pfam05065 573235009974 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 573235009975 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 573235009976 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 573235009977 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 573235009978 active site 573235009979 PerC transcriptional activator; Region: PerC; pfam06069 573235009980 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 573235009981 Lipoprotein Rz1 precursor; Region: Rz1; pfam06085 573235009982 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 573235009983 catalytic residues [active] 573235009984 Lysis protein S; Region: Lysis_S; pfam04971 573235009985 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 573235009986 Domain of unknown function (DUF303); Region: DUF303; pfam03629 573235009987 Antitermination protein; Region: Antiterm; pfam03589 573235009988 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 573235009989 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 573235009990 Zn binding sites [ion binding]; other site 573235009991 Antitermination protein; Region: Antiterm; pfam03589 573235009992 Protein of unknown function (DUF968); Region: DUF968; pfam06147 573235009993 KilA-N domain; Region: KilA-N; pfam04383 573235009994 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 573235009995 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 573235009996 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; pfam05869 573235009997 PerC transcriptional activator; Region: PerC; pfam06069 573235009998 Helix-turn-helix domain; Region: HTH_36; pfam13730 573235009999 Ash protein family; Region: Phage_ASH; pfam10554 573235010000 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 573235010001 Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197 573235010002 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 573235010003 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 573235010004 Catalytic site [active] 573235010005 Uncharacterized conserved protein [Function unknown]; Region: COG5532 573235010006 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 573235010007 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 573235010008 Active Sites [active] 573235010009 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 573235010010 Protein of unknown function (DUF551); Region: DUF551; pfam04448 573235010011 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 573235010012 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 573235010013 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 573235010014 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 573235010015 Int/Topo IB signature motif; other site 573235010016 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176 573235010017 Integrative element ECO26_IE05 573235010018 integrase; Provisional; Region: PRK09692 573235010019 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 573235010020 active site 573235010021 Int/Topo IB signature motif; other site 573235010022 Integrative element ECO26_IE05; predicted histidine kinase, C-terminal fragment 573235010023 Integrative element ECO26_IE05; predicted transposase InsF of insertion sequence IS3, C-terminal part 573235010024 Integrative element ECO26_IE05; predicted transposase InsF of insertion sequence IS3, N-terminal part 573235010025 Transposase; Region: HTH_Tnp_1; cl17663 573235010026 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 573235010027 conserved predicted protein, C-terminal part 573235010028 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 573235010029 substrate binding pocket [chemical binding]; other site 573235010030 active site 573235010031 iron coordination sites [ion binding]; other site 573235010032 Predicted dehydrogenase [General function prediction only]; Region: COG0579 573235010033 hydroxyglutarate oxidase; Provisional; Region: PRK11728 573235010034 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 573235010035 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 573235010036 tetramerization interface [polypeptide binding]; other site 573235010037 NAD(P) binding site [chemical binding]; other site 573235010038 catalytic residues [active] 573235010039 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 573235010040 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 573235010041 inhibitor-cofactor binding pocket; inhibition site 573235010042 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573235010043 catalytic residue [active] 573235010044 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 573235010045 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 573235010046 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573235010047 DNA-binding site [nucleotide binding]; DNA binding site 573235010048 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 573235010049 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 573235010050 bacterial OsmY and nodulation domain; Region: BON; smart00749 573235010051 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 573235010052 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 573235010053 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573235010054 dimerization interface [polypeptide binding]; other site 573235010055 putative DNA binding site [nucleotide binding]; other site 573235010056 Transcriptional regulators [Transcription]; Region: MarR; COG1846 573235010057 putative Zn2+ binding site [ion binding]; other site 573235010058 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YgaP, and similar uncharacterized putative rhodanese-related sulfurtransferases; Region: RHOD_YgaP; cd01527 573235010059 active site residue [active] 573235010060 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 573235010061 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 573235010062 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 573235010063 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 573235010064 hypothetical protein; Provisional; Region: PRK10556 573235010065 hypothetical protein; Provisional; Region: PRK10132 573235010066 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 573235010067 catalytic residues [active] 573235010068 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 573235010069 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 573235010070 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 573235010071 Class I ribonucleotide reductase; Region: RNR_I; cd01679 573235010072 active site 573235010073 dimer interface [polypeptide binding]; other site 573235010074 catalytic residues [active] 573235010075 effector binding site; other site 573235010076 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 573235010077 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 573235010078 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 573235010079 dimer interface [polypeptide binding]; other site 573235010080 putative radical transfer pathway; other site 573235010081 diiron center [ion binding]; other site 573235010082 tyrosyl radical; other site 573235010083 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 573235010084 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 573235010085 Walker A/P-loop; other site 573235010086 ATP binding site [chemical binding]; other site 573235010087 Q-loop/lid; other site 573235010088 ABC transporter signature motif; other site 573235010089 Walker B; other site 573235010090 D-loop; other site 573235010091 H-loop/switch region; other site 573235010092 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 573235010093 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 573235010094 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573235010095 dimer interface [polypeptide binding]; other site 573235010096 conserved gate region; other site 573235010097 putative PBP binding loops; other site 573235010098 ABC-ATPase subunit interface; other site 573235010099 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 573235010100 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 573235010101 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 573235010102 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235010103 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 573235010104 putative L-valine exporter; Provisional; Region: PRK10408 573235010105 transcriptional repressor MprA; Provisional; Region: PRK10870 573235010106 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 573235010107 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 573235010108 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 573235010109 HlyD family secretion protein; Region: HlyD_3; pfam13437 573235010110 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 573235010111 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235010112 putative substrate translocation pore; other site 573235010113 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235010114 S-ribosylhomocysteinase; Provisional; Region: PRK02260 573235010115 glutamate--cysteine ligase; Provisional; Region: PRK02107 573235010116 Predicted membrane protein [Function unknown]; Region: COG1238 573235010117 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 573235010118 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573235010119 motif II; other site 573235010120 carbon storage regulator; Provisional; Region: PRK01712 573235010121 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 573235010122 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 573235010123 motif 1; other site 573235010124 active site 573235010125 motif 2; other site 573235010126 motif 3; other site 573235010127 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 573235010128 DHHA1 domain; Region: DHHA1; pfam02272 573235010129 recombination regulator RecX; Reviewed; Region: recX; PRK00117 573235010130 recombinase A; Provisional; Region: recA; PRK09354 573235010131 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 573235010132 hexamer interface [polypeptide binding]; other site 573235010133 Walker A motif; other site 573235010134 ATP binding site [chemical binding]; other site 573235010135 Walker B motif; other site 573235010136 hypothetical protein; Validated; Region: PRK03661 573235010137 Transglycosylase SLT domain; Region: SLT_2; pfam13406 573235010138 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 573235010139 N-acetyl-D-glucosamine binding site [chemical binding]; other site 573235010140 PTS system, glucitol/sorbitol-specific, IIC component; Region: EII-GUT; TIGR00821 573235010141 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 573235010142 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 573235010143 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 573235010144 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 573235010145 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 573235010146 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 573235010147 putative NAD(P) binding site [chemical binding]; other site 573235010148 active site 573235010149 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 573235010150 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 573235010151 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 573235010152 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 573235010153 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 573235010154 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 573235010155 putative active site [active] 573235010156 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 573235010157 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 573235010158 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 573235010159 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573235010160 Walker A motif; other site 573235010161 ATP binding site [chemical binding]; other site 573235010162 Walker B motif; other site 573235010163 arginine finger; other site 573235010164 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 573235010165 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 573235010166 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 573235010167 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 573235010168 iron binding site [ion binding]; other site 573235010169 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 573235010170 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 573235010171 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 573235010172 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 573235010173 Acylphosphatase; Region: Acylphosphatase; pfam00708 573235010174 HypF finger; Region: zf-HYPF; pfam07503 573235010175 HypF finger; Region: zf-HYPF; pfam07503 573235010176 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 573235010177 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 573235010178 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 573235010179 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573235010180 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573235010181 DNA binding site [nucleotide binding] 573235010182 domain linker motif; other site 573235010183 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 573235010184 dimerization interface (closed form) [polypeptide binding]; other site 573235010185 ligand binding site [chemical binding]; other site 573235010186 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 573235010187 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 573235010188 active site turn [active] 573235010189 phosphorylation site [posttranslational modification] 573235010190 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 573235010191 cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852 573235010192 beta-galactosidase; Region: BGL; TIGR03356 573235010193 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573235010194 non-specific DNA binding site [nucleotide binding]; other site 573235010195 salt bridge; other site 573235010196 sequence-specific DNA binding site [nucleotide binding]; other site 573235010197 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 573235010198 nickel binding site [ion binding]; other site 573235010199 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 573235010200 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 573235010201 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 573235010202 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 573235010203 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 573235010204 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 573235010205 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 573235010206 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 573235010207 NADH dehydrogenase; Region: NADHdh; cl00469 573235010208 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 573235010209 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 573235010210 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 573235010211 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 573235010212 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 573235010213 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 573235010214 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 573235010215 hydrogenase assembly chaperone; Provisional; Region: PRK10409 573235010216 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 573235010217 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 573235010218 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 573235010219 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 573235010220 dimerization interface [polypeptide binding]; other site 573235010221 ATP binding site [chemical binding]; other site 573235010222 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 573235010223 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 573235010224 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 573235010225 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573235010226 Walker A motif; other site 573235010227 ATP binding site [chemical binding]; other site 573235010228 Walker B motif; other site 573235010229 arginine finger; other site 573235010230 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 573235010231 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 573235010232 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 573235010233 MutS domain I; Region: MutS_I; pfam01624 573235010234 MutS domain II; Region: MutS_II; pfam05188 573235010235 MutS domain III; Region: MutS_III; pfam05192 573235010236 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 573235010237 Walker A/P-loop; other site 573235010238 ATP binding site [chemical binding]; other site 573235010239 Q-loop/lid; other site 573235010240 ABC transporter signature motif; other site 573235010241 Walker B; other site 573235010242 D-loop; other site 573235010243 H-loop/switch region; other site 573235010244 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 573235010245 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 573235010246 active site 573235010247 metal binding site [ion binding]; metal-binding site 573235010248 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 573235010249 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 573235010250 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 573235010251 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 573235010252 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 573235010253 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 573235010254 putative aldolase; Validated; Region: PRK08130 573235010255 active site 573235010256 intersubunit interface [polypeptide binding]; other site 573235010257 Zn2+ binding site [ion binding]; other site 573235010258 hypothetical protein; Provisional; Region: PRK09989 573235010259 putative transporter; Provisional; Region: PRK09821 573235010260 GntP family permease; Region: GntP_permease; pfam02447 573235010261 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 573235010262 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 573235010263 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 573235010264 Flavoprotein; Region: Flavoprotein; pfam02441 573235010265 MarR family; Region: MarR_2; cl17246 573235010266 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 573235010267 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 573235010268 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 573235010269 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573235010270 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 573235010271 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573235010272 DNA binding residues [nucleotide binding] 573235010273 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 573235010274 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 573235010275 Peptidase family M23; Region: Peptidase_M23; pfam01551 573235010276 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 573235010277 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573235010278 S-adenosylmethionine binding site [chemical binding]; other site 573235010279 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 573235010280 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 573235010281 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 573235010282 Permutation of conserved domain; other site 573235010283 active site 573235010284 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 573235010285 homotrimer interaction site [polypeptide binding]; other site 573235010286 zinc binding site [ion binding]; other site 573235010287 CDP-binding sites; other site 573235010288 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 573235010289 substrate binding site; other site 573235010290 dimer interface; other site 573235010291 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 573235010292 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 573235010293 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 573235010294 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 573235010295 ligand-binding site [chemical binding]; other site 573235010296 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 573235010297 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 573235010298 CysD dimerization site [polypeptide binding]; other site 573235010299 G1 box; other site 573235010300 putative GEF interaction site [polypeptide binding]; other site 573235010301 GTP/Mg2+ binding site [chemical binding]; other site 573235010302 Switch I region; other site 573235010303 G2 box; other site 573235010304 G3 box; other site 573235010305 Switch II region; other site 573235010306 G4 box; other site 573235010307 G5 box; other site 573235010308 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 573235010309 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 573235010310 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 573235010311 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 573235010312 Active Sites [active] 573235010313 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 573235010314 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 573235010315 metal binding site [ion binding]; metal-binding site 573235010316 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648 573235010317 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 573235010318 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09664 573235010319 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 573235010320 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 573235010321 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cd09646 573235010322 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cl09719 573235010323 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09669 573235010324 helicase, C-terminal part 573235010325 helicase, N-terminal part 573235010326 Hok/gef family; Region: HOK_GEF; pfam01848 573235010327 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 573235010328 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 573235010329 Active Sites [active] 573235010330 sulfite reductase subunit beta; Provisional; Region: PRK13504 573235010331 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 573235010332 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 573235010333 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 573235010334 Flavodoxin; Region: Flavodoxin_1; pfam00258 573235010335 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 573235010336 FAD binding pocket [chemical binding]; other site 573235010337 FAD binding motif [chemical binding]; other site 573235010338 catalytic residues [active] 573235010339 NAD binding pocket [chemical binding]; other site 573235010340 phosphate binding motif [ion binding]; other site 573235010341 beta-alpha-beta structure motif; other site 573235010342 6-pyruvoyl tetrahydropterin synthase (PTPS). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids, as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after uptake by a...; Region: PTPS; cd00470 573235010343 homohexamer interface [polypeptide binding]; other site 573235010344 putative substrate stabilizing pore; other site 573235010345 pterin binding site; other site 573235010346 oxidoreductase; Provisional; Region: PRK10015 573235010347 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 573235010348 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 573235010349 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 573235010350 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 573235010351 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 573235010352 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 573235010353 Ligand binding site [chemical binding]; other site 573235010354 Electron transfer flavoprotein domain; Region: ETF; pfam01012 573235010355 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 573235010356 benzoate transport; Region: 2A0115; TIGR00895 573235010357 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235010358 putative substrate translocation pore; other site 573235010359 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 573235010360 FAD binding domain; Region: FAD_binding_4; pfam01565 573235010361 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 573235010362 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 573235010363 NADP binding site [chemical binding]; other site 573235010364 homodimer interface [polypeptide binding]; other site 573235010365 active site 573235010366 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573235010367 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235010368 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 573235010369 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 573235010370 nucleotide binding site [chemical binding]; other site 573235010371 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 573235010372 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 573235010373 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 573235010374 Repair protein; Region: Repair_PSII; pfam04536 573235010375 enolase; Provisional; Region: eno; PRK00077 573235010376 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 573235010377 dimer interface [polypeptide binding]; other site 573235010378 metal binding site [ion binding]; metal-binding site 573235010379 substrate binding pocket [chemical binding]; other site 573235010380 CTP synthetase; Validated; Region: pyrG; PRK05380 573235010381 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 573235010382 Catalytic site [active] 573235010383 active site 573235010384 UTP binding site [chemical binding]; other site 573235010385 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 573235010386 active site 573235010387 putative oxyanion hole; other site 573235010388 catalytic triad [active] 573235010389 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 573235010390 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 573235010391 homodimer interface [polypeptide binding]; other site 573235010392 metal binding site [ion binding]; metal-binding site 573235010393 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 573235010394 homodimer interface [polypeptide binding]; other site 573235010395 active site 573235010396 putative chemical substrate binding site [chemical binding]; other site 573235010397 metal binding site [ion binding]; metal-binding site 573235010398 toxin MazF; Provisional; Region: PRK09907 573235010399 antitoxin MazE; Provisional; Region: PRK09798 573235010400 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 573235010401 HD domain; Region: HD_4; pfam13328 573235010402 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 573235010403 synthetase active site [active] 573235010404 NTP binding site [chemical binding]; other site 573235010405 metal binding site [ion binding]; metal-binding site 573235010406 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 573235010407 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 573235010408 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 573235010409 TRAM domain; Region: TRAM; pfam01938 573235010410 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573235010411 S-adenosylmethionine binding site [chemical binding]; other site 573235010412 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 573235010413 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 573235010414 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573235010415 dimerization interface [polypeptide binding]; other site 573235010416 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573235010417 dimer interface [polypeptide binding]; other site 573235010418 phosphorylation site [posttranslational modification] 573235010419 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573235010420 ATP binding site [chemical binding]; other site 573235010421 Mg2+ binding site [ion binding]; other site 573235010422 G-X-G motif; other site 573235010423 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 573235010424 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573235010425 active site 573235010426 phosphorylation site [posttranslational modification] 573235010427 intermolecular recognition site; other site 573235010428 dimerization interface [polypeptide binding]; other site 573235010429 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 573235010430 putative binding surface; other site 573235010431 active site 573235010432 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 573235010433 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 573235010434 active site 573235010435 tetramer interface [polypeptide binding]; other site 573235010436 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 573235010437 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 573235010438 active site 573235010439 tetramer interface [polypeptide binding]; other site 573235010440 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235010441 D-galactonate transporter; Region: 2A0114; TIGR00893 573235010442 putative substrate translocation pore; other site 573235010443 flavodoxin; Provisional; Region: PRK08105 573235010444 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 573235010445 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 573235010446 probable active site [active] 573235010447 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 573235010448 SecY interacting protein Syd; Provisional; Region: PRK04968 573235010449 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 573235010450 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 573235010451 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 573235010452 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 573235010453 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 573235010454 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 573235010455 serine transporter; Region: stp; TIGR00814 573235010456 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 573235010457 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 573235010458 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 573235010459 flap endonuclease-like protein; Provisional; Region: PRK09482 573235010460 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 573235010461 active site 573235010462 metal binding site 1 [ion binding]; metal-binding site 573235010463 putative 5' ssDNA interaction site; other site 573235010464 metal binding site 3; metal-binding site 573235010465 metal binding site 2 [ion binding]; metal-binding site 573235010466 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 573235010467 putative DNA binding site [nucleotide binding]; other site 573235010468 putative metal binding site [ion binding]; other site 573235010469 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 573235010470 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 573235010471 dimer interface [polypeptide binding]; other site 573235010472 active site 573235010473 metal binding site [ion binding]; metal-binding site 573235010474 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 573235010475 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 573235010476 intersubunit interface [polypeptide binding]; other site 573235010477 active site 573235010478 Zn2+ binding site [ion binding]; other site 573235010479 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 573235010480 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235010481 putative substrate translocation pore; other site 573235010482 L-fucose isomerase; Provisional; Region: fucI; PRK10991 573235010483 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 573235010484 hexamer (dimer of trimers) interface [polypeptide binding]; other site 573235010485 trimer interface [polypeptide binding]; other site 573235010486 substrate binding site [chemical binding]; other site 573235010487 Mn binding site [ion binding]; other site 573235010488 L-fuculokinase; Provisional; Region: PRK10331 573235010489 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 573235010490 nucleotide binding site [chemical binding]; other site 573235010491 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 573235010492 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 573235010493 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 573235010494 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 573235010495 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 573235010496 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 573235010497 hypothetical protein; Provisional; Region: PRK10873 573235010498 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 573235010499 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573235010500 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 573235010501 dimerization interface [polypeptide binding]; other site 573235010502 substrate binding pocket [chemical binding]; other site 573235010503 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 573235010504 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 573235010505 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 573235010506 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 573235010507 catalytic residue [active] 573235010508 CsdA-binding activator; Provisional; Region: PRK15019 573235010509 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 573235010510 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 573235010511 putative ATP binding site [chemical binding]; other site 573235010512 putative substrate interface [chemical binding]; other site 573235010513 murein transglycosylase A; Provisional; Region: mltA; PRK11162 573235010514 MltA specific insert domain; Region: MltA; pfam03562 573235010515 3D domain; Region: 3D; pfam06725 573235010516 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 573235010517 putative ligand binding site [chemical binding]; other site 573235010518 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 573235010519 putative NAD binding site [chemical binding]; other site 573235010520 catalytic site [active] 573235010521 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 573235010522 putative active site [active] 573235010523 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 573235010524 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573235010525 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573235010526 homodimer interface [polypeptide binding]; other site 573235010527 catalytic residue [active] 573235010528 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 573235010529 PTS system, maltose and glucose-specific IIBC component; Region: PTS-IIBC-malX; TIGR02004 573235010530 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 573235010531 active site turn [active] 573235010532 phosphorylation site [posttranslational modification] 573235010533 CAT RNA binding domain; Region: CAT_RBD; pfam03123 573235010534 PRD domain; Region: PRD; pfam00874 573235010535 PRD domain; Region: PRD; pfam00874 573235010536 AMIN domain; Region: AMIN; pfam11741 573235010537 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 573235010538 active site 573235010539 metal binding site [ion binding]; metal-binding site 573235010540 N-acetylglutamate synthase; Validated; Region: PRK05279 573235010541 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 573235010542 putative feedback inhibition sensing region; other site 573235010543 putative nucleotide binding site [chemical binding]; other site 573235010544 putative substrate binding site [chemical binding]; other site 573235010545 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573235010546 Coenzyme A binding pocket [chemical binding]; other site 573235010547 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 573235010548 AAA domain; Region: AAA_30; pfam13604 573235010549 Family description; Region: UvrD_C_2; pfam13538 573235010550 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 573235010551 protease3; Provisional; Region: PRK15101 573235010552 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 573235010553 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 573235010554 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 573235010555 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 573235010556 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 573235010557 hypothetical protein; Provisional; Region: PRK10332 573235010558 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 573235010559 hypothetical protein; Provisional; Region: PRK11521 573235010560 hypothetical protein; Provisional; Region: PRK10557 573235010561 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 573235010562 hypothetical protein; Provisional; Region: PRK10506 573235010563 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 573235010564 thymidylate synthase; Reviewed; Region: thyA; PRK01827 573235010565 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 573235010566 dimerization interface [polypeptide binding]; other site 573235010567 active site 573235010568 prolipoprotein diacylglyceryl transferase; Region: lgt; TIGR00544 573235010569 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 573235010570 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 573235010571 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 573235010572 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 573235010573 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 573235010574 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 573235010575 putative active site [active] 573235010576 Ap4A binding site [chemical binding]; other site 573235010577 nudix motif; other site 573235010578 putative metal binding site [ion binding]; other site 573235010579 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 573235010580 putative DNA-binding cleft [nucleotide binding]; other site 573235010581 putative DNA clevage site; other site 573235010582 molecular lever; other site 573235010583 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 573235010584 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 573235010585 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 573235010586 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 573235010587 active site 573235010588 catalytic tetrad [active] 573235010589 lysophospholipid transporter LplT; Provisional; Region: PRK11195 573235010590 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235010591 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 573235010592 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 573235010593 putative acyl-acceptor binding pocket; other site 573235010594 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 573235010595 acyl-activating enzyme (AAE) consensus motif; other site 573235010596 putative AMP binding site [chemical binding]; other site 573235010597 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 573235010598 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573235010599 DNA binding site [nucleotide binding] 573235010600 domain linker motif; other site 573235010601 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 573235010602 dimerization interface (closed form) [polypeptide binding]; other site 573235010603 ligand binding site [chemical binding]; other site 573235010604 diaminopimelate decarboxylase; Provisional; Region: PRK11165 573235010605 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 573235010606 active site 573235010607 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 573235010608 substrate binding site [chemical binding]; other site 573235010609 catalytic residues [active] 573235010610 dimer interface [polypeptide binding]; other site 573235010611 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 573235010612 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573235010613 The C-terminal substrate binding domain of LysR, transcriptional regulator for lysine biosynthesis, contains the type 2 periplasmic binding fold; Region: PBP2_LysR; cd08456 573235010614 putative dimerization interface [polypeptide binding]; other site 573235010615 putative racemase; Provisional; Region: PRK10200 573235010616 aspartate racemase; Region: asp_race; TIGR00035 573235010617 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 573235010618 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235010619 putative substrate translocation pore; other site 573235010620 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235010621 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 573235010622 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 573235010623 NADP binding site [chemical binding]; other site 573235010624 homodimer interface [polypeptide binding]; other site 573235010625 active site 573235010626 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 573235010627 putative acyltransferase; Provisional; Region: PRK05790 573235010628 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 573235010629 dimer interface [polypeptide binding]; other site 573235010630 active site 573235010631 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 573235010632 serine transporter; Region: stp; TIGR00814 573235010633 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 573235010634 DNA binding residues [nucleotide binding] 573235010635 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 573235010636 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 573235010637 hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264 573235010638 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 573235010639 Tetratricopeptide repeat; Region: TPR_3; pfam07720 573235010640 Tetratricopeptide repeat; Region: TPR_3; pfam07720 573235010641 transcriptional regulator; Provisional; Region: PRK11906 573235010642 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 573235010643 DNA binding site [nucleotide binding] 573235010644 TPR motif; other site 573235010645 Tetratricopeptide repeat; Region: TPR_2; pfam07719 573235010646 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 573235010647 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 573235010648 N-acetyl-D-glucosamine binding site [chemical binding]; other site 573235010649 catalytic residue [active] 573235010650 predicted DNA-binding transcriptional regulator, C-terminal part 573235010651 conserved predicted protein, N-terminal part 573235010652 invasion protein OrgB; Provisional; Region: PRK15322 573235010653 type III secretion apparatus protein OrgA/MxiK; Region: OrgA_MxiK; TIGR02555 573235010654 Type III secretory pathway, lipoprotein EscJ [Intracellular trafficking and secretion]; Region: EscJ; COG4669 573235010655 type III secretion system needle complex protein PrgJ; Provisional; Region: PRK15325 573235010656 Type III secretion needle MxiH like; Region: MxiH; cl09641 573235010657 type III secretion system needle complex protein PrgH; Provisional; Region: PRK15327; cl12363 573235010658 Type III secretion system protein PrgH-EprH (PrgH); Region: PrgH; pfam09480 573235010659 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573235010660 DNA binding residues [nucleotide binding] 573235010661 type III secretion protein EprS, C-terminal part 573235010662 type III secretion protein EprS, N-terminal part 573235010663 type III secretion protein SpaR/YscT/HrcT; Region: fliR_like_III; TIGR01401 573235010664 type III secretion system protein SpaQ; Provisional; Region: PRK15333 573235010665 type III secretion system protein SpaP; Provisional; Region: spaP; PRK12796 573235010666 predicted type III secretion protein EpaO, C-terminal part 573235010667 type III secretion protein EpaO, N-terminal part 573235010668 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 573235010669 Integrative element ECO26_IE06 573235010670 Protein of unknown function (DUF1682); Region: DUF1682; pfam07946 573235010671 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 573235010672 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 573235010673 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573235010674 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 573235010675 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 573235010676 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 573235010677 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573235010678 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 573235010679 Transposase; Region: HTH_Tnp_1; pfam01527 573235010680 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 573235010681 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 573235010682 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 573235010683 INT_SG2, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 2, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinases and phage-related integrases. Some have N-terminal domains, which show little sequence...; Region: INT_SG2_C; cd01184 573235010684 Int/Topo IB signature motif; other site 573235010685 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 573235010686 Peptidase family M23; Region: Peptidase_M23; pfam01551 573235010687 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 573235010688 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 573235010689 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 573235010690 xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971 573235010691 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 573235010692 xanthine dehydrogenase subunit XdhC; Provisional; Region: PRK09908 573235010693 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 573235010694 catalytic loop [active] 573235010695 iron binding site [ion binding]; other site 573235010696 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 573235010697 GAF domain; Region: GAF; cl17456 573235010698 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 573235010699 PAS domain; Region: PAS; smart00091 573235010700 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573235010701 Walker A motif; other site 573235010702 ATP binding site [chemical binding]; other site 573235010703 Walker B motif; other site 573235010704 arginine finger; other site 573235010705 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 573235010706 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 573235010707 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 573235010708 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 573235010709 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 573235010710 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 573235010711 catalytic residue [active] 573235010712 peptidase; Reviewed; Region: PRK13004 573235010713 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 573235010714 putative metal binding site [ion binding]; other site 573235010715 putative dimer interface [polypeptide binding]; other site 573235010716 D-hydantoinase; Region: D-hydantoinase; TIGR02033 573235010717 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 573235010718 tetramer interface [polypeptide binding]; other site 573235010719 active site 573235010720 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 573235010721 carbamate kinase; Reviewed; Region: PRK12686 573235010722 putative substrate binding site [chemical binding]; other site 573235010723 homodimer interface [polypeptide binding]; other site 573235010724 nucleotide binding site [chemical binding]; other site 573235010725 nucleotide binding site [chemical binding]; other site 573235010726 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 573235010727 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 573235010728 XdhC Rossmann domain; Region: XdhC_C; pfam13478 573235010729 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 573235010730 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 573235010731 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 573235010732 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 573235010733 Ligand binding site; other site 573235010734 metal-binding site 573235010735 putative selenate reductase subunit YgfK; Provisional; Region: PRK09853 573235010736 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 573235010737 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 573235010738 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 573235010739 putative selenium metabolism protein SsnA; Region: Se_ssnA; TIGR03314 573235010740 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 573235010741 active site 573235010742 putative substrate binding pocket [chemical binding]; other site 573235010743 probable selenate reductase, FAD-binding subunit; Region: Se_sel_red_FAD; TIGR03312 573235010744 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 573235010745 putative hypoxanthine oxidase; Provisional; Region: PRK09800 573235010746 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 573235010747 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 573235010748 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 573235010749 uracil-xanthine permease; Region: ncs2; TIGR00801 573235010750 guanine deaminase; Provisional; Region: PRK09228 573235010751 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 573235010752 active site 573235010753 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 573235010754 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 573235010755 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12809 573235010756 4Fe-4S binding domain; Region: Fer4; pfam00037 573235010757 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 573235010758 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 573235010759 xanthine permease; Region: pbuX; TIGR03173 573235010760 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 573235010761 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 573235010762 active site 573235010763 metal binding site [ion binding]; metal-binding site 573235010764 nudix motif; other site 573235010765 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 573235010766 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 573235010767 dimer interface [polypeptide binding]; other site 573235010768 putative anticodon binding site; other site 573235010769 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 573235010770 motif 1; other site 573235010771 active site 573235010772 motif 2; other site 573235010773 motif 3; other site 573235010774 peptide chain release factor 2; Validated; Region: prfB; PRK00578 573235010775 This domain is found in peptide chain release factors; Region: PCRF; smart00937 573235010776 RF-1 domain; Region: RF-1; pfam00472 573235010777 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 573235010778 DHH family; Region: DHH; pfam01368 573235010779 DHHA1 domain; Region: DHHA1; pfam02272 573235010780 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 573235010781 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 573235010782 dimerization domain [polypeptide binding]; other site 573235010783 dimer interface [polypeptide binding]; other site 573235010784 catalytic residues [active] 573235010785 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 573235010786 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 573235010787 active site 573235010788 Int/Topo IB signature motif; other site 573235010789 flavodoxin FldB; Provisional; Region: PRK12359 573235010790 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 573235010791 hypothetical protein; Provisional; Region: PRK10878 573235010792 putative global regulator; Reviewed; Region: PRK09559 573235010793 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 573235010794 hemolysin; Provisional; Region: PRK15087 573235010795 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 573235010796 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 573235010797 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 573235010798 beta-galactosidase; Region: BGL; TIGR03356 573235010799 putative NAD(P)-binding oxidoreductase; Provisional; Region: PRK09730 573235010800 classical (c) SDRs; Region: SDR_c; cd05233 573235010801 NAD(P) binding site [chemical binding]; other site 573235010802 active site 573235010803 glycine dehydrogenase; Provisional; Region: PRK05367 573235010804 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 573235010805 tetramer interface [polypeptide binding]; other site 573235010806 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573235010807 catalytic residue [active] 573235010808 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 573235010809 tetramer interface [polypeptide binding]; other site 573235010810 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573235010811 catalytic residue [active] 573235010812 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 573235010813 lipoyl attachment site [posttranslational modification]; other site 573235010814 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 573235010815 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 573235010816 oxidoreductase; Provisional; Region: PRK08013 573235010817 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 573235010818 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 573235010819 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 573235010820 proline aminopeptidase P II; Provisional; Region: PRK10879 573235010821 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 573235010822 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 573235010823 active site 573235010824 hypothetical protein; Reviewed; Region: PRK01736 573235010825 Z-ring-associated protein; Provisional; Region: PRK10972 573235010826 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 573235010827 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 573235010828 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 573235010829 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 573235010830 ligand binding site [chemical binding]; other site 573235010831 NAD binding site [chemical binding]; other site 573235010832 tetramer interface [polypeptide binding]; other site 573235010833 catalytic site [active] 573235010834 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 573235010835 L-serine binding site [chemical binding]; other site 573235010836 ACT domain interface; other site 573235010837 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 573235010838 tetramer (dimer of dimers) interface [polypeptide binding]; other site 573235010839 active site 573235010840 dimer interface [polypeptide binding]; other site 573235010841 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 573235010842 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573235010843 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 573235010844 putative dimerization interface [polypeptide binding]; other site 573235010845 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 573235010846 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 573235010847 active site 573235010848 substrate binding site [chemical binding]; other site 573235010849 coenzyme B12 binding site [chemical binding]; other site 573235010850 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 573235010851 B12 binding site [chemical binding]; other site 573235010852 cobalt ligand [ion binding]; other site 573235010853 membrane ATPase/protein kinase; Provisional; Region: PRK09435 573235010854 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 573235010855 Walker A; other site 573235010856 methylmalonyl-CoA decarboxylase; Provisional; Region: PRK11423 573235010857 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 573235010858 substrate binding site [chemical binding]; other site 573235010859 oxyanion hole (OAH) forming residues; other site 573235010860 trimer interface [polypeptide binding]; other site 573235010861 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 573235010862 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 573235010863 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 573235010864 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573235010865 Transcriptional regulator [Transcription]; Region: LysR; COG0583 573235010866 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 573235010867 dimerization interface [polypeptide binding]; other site 573235010868 Uncharacterized conserved protein [Function unknown]; Region: COG2968 573235010869 oxidative stress defense protein; Provisional; Region: PRK11087 573235010870 arginine exporter protein; Provisional; Region: PRK09304 573235010871 mechanosensitive channel MscS; Provisional; Region: PRK10334 573235010872 Mechanosensitive ion channel; Region: MS_channel; pfam00924 573235010873 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 573235010874 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 573235010875 active site 573235010876 intersubunit interface [polypeptide binding]; other site 573235010877 zinc binding site [ion binding]; other site 573235010878 Na+ binding site [ion binding]; other site 573235010879 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 573235010880 Phosphoglycerate kinase; Region: PGK; pfam00162 573235010881 substrate binding site [chemical binding]; other site 573235010882 hinge regions; other site 573235010883 ADP binding site [chemical binding]; other site 573235010884 catalytic site [active] 573235010885 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 573235010886 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 573235010887 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 573235010888 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 573235010889 trimer interface [polypeptide binding]; other site 573235010890 putative Zn binding site [ion binding]; other site 573235010891 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 573235010892 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 573235010893 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 573235010894 Walker A/P-loop; other site 573235010895 ATP binding site [chemical binding]; other site 573235010896 Q-loop/lid; other site 573235010897 ABC transporter signature motif; other site 573235010898 Walker B; other site 573235010899 D-loop; other site 573235010900 H-loop/switch region; other site 573235010901 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 573235010902 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 573235010903 Walker A/P-loop; other site 573235010904 ATP binding site [chemical binding]; other site 573235010905 Q-loop/lid; other site 573235010906 ABC transporter signature motif; other site 573235010907 Walker B; other site 573235010908 D-loop; other site 573235010909 H-loop/switch region; other site 573235010910 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 573235010911 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 573235010912 active site 573235010913 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 573235010914 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10022 573235010915 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 573235010916 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 573235010917 putative active site [active] 573235010918 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 573235010919 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 573235010920 putative NAD(P) binding site [chemical binding]; other site 573235010921 catalytic Zn binding site [ion binding]; other site 573235010922 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 573235010923 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 573235010924 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 573235010925 active site 573235010926 P-loop; other site 573235010927 phosphorylation site [posttranslational modification] 573235010928 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 573235010929 active site 573235010930 phosphorylation site [posttranslational modification] 573235010931 transketolase; Reviewed; Region: PRK12753 573235010932 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 573235010933 TPP-binding site [chemical binding]; other site 573235010934 dimer interface [polypeptide binding]; other site 573235010935 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 573235010936 PYR/PP interface [polypeptide binding]; other site 573235010937 dimer interface [polypeptide binding]; other site 573235010938 TPP binding site [chemical binding]; other site 573235010939 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 573235010940 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 573235010941 Protein of unknown function (DUF1341); Region: DUF1341; cl06211 573235010942 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 573235010943 L-seryl-tRNA selenium transferase; Region: SelA; pfam03841 573235010944 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 573235010945 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 573235010946 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 573235010947 active site 573235010948 phosphorylation site [posttranslational modification] 573235010949 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 573235010950 active pocket/dimerization site; other site 573235010951 active site 573235010952 phosphorylation site [posttranslational modification] 573235010953 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 573235010954 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573235010955 Walker A motif; other site 573235010956 ATP binding site [chemical binding]; other site 573235010957 Walker B motif; other site 573235010958 arginine finger; other site 573235010959 Transcriptional antiterminator [Transcription]; Region: COG3933 573235010960 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 573235010961 active site 573235010962 active pocket/dimerization site; other site 573235010963 phosphorylation site [posttranslational modification] 573235010964 PRD domain; Region: PRD; pfam00874 573235010965 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 573235010966 agmatinase; Region: agmatinase; TIGR01230 573235010967 oligomer interface [polypeptide binding]; other site 573235010968 putative active site [active] 573235010969 Mn binding site [ion binding]; other site 573235010970 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 573235010971 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 573235010972 dimer interface [polypeptide binding]; other site 573235010973 active site 573235010974 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 573235010975 catalytic residues [active] 573235010976 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 573235010977 Virulence promoting factor; Region: YqgB; pfam11036 573235010978 Protein of unknown function (DUF2684); Region: DUF2684; pfam10885 573235010979 S-adenosylmethionine synthetase; Validated; Region: PRK05250 573235010980 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 573235010981 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 573235010982 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 573235010983 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 573235010984 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235010985 putative substrate translocation pore; other site 573235010986 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235010987 hypothetical protein; Provisional; Region: PRK04860 573235010988 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 573235010989 DNA-specific endonuclease I; Provisional; Region: PRK15137 573235010990 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 573235010991 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 573235010992 RNA methyltransferase, RsmE family; Region: TIGR00046 573235010993 glutathione synthetase; Provisional; Region: PRK05246 573235010994 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 573235010995 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 573235010996 hypothetical protein; Validated; Region: PRK00228 573235010997 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 573235010998 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 573235010999 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 573235011000 Walker A motif; other site 573235011001 ATP binding site [chemical binding]; other site 573235011002 Walker B motif; other site 573235011003 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 573235011004 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 573235011005 catalytic residue [active] 573235011006 YGGT family; Region: YGGT; pfam02325 573235011007 YGGT family; Region: YGGT; pfam02325 573235011008 hypothetical protein; Validated; Region: PRK05090 573235011009 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 573235011010 active site 573235011011 dimerization interface [polypeptide binding]; other site 573235011012 HemN family oxidoreductase; Provisional; Region: PRK05660 573235011013 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573235011014 FeS/SAM binding site; other site 573235011015 HemN C-terminal domain; Region: HemN_C; pfam06969 573235011016 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 573235011017 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 573235011018 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 573235011019 DctM-like transporters; Region: DctM; pfam06808 573235011020 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 573235011021 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 573235011022 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 573235011023 homodimer interface [polypeptide binding]; other site 573235011024 active site 573235011025 hypothetical protein; Provisional; Region: PRK10626 573235011026 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 573235011027 hypothetical protein; Provisional; Region: PRK11702 573235011028 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 573235011029 adenine DNA glycosylase; Provisional; Region: PRK10880 573235011030 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 573235011031 minor groove reading motif; other site 573235011032 helix-hairpin-helix signature motif; other site 573235011033 substrate binding pocket [chemical binding]; other site 573235011034 active site 573235011035 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 573235011036 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 573235011037 DNA binding and oxoG recognition site [nucleotide binding] 573235011038 oxidative damage protection protein; Provisional; Region: PRK05408 573235011039 murein transglycosylase C; Provisional; Region: mltC; PRK11671 573235011040 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 573235011041 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 573235011042 N-acetyl-D-glucosamine binding site [chemical binding]; other site 573235011043 catalytic residue [active] 573235011044 nucleoside transporter; Region: 2A0110; TIGR00889 573235011045 ornithine decarboxylase; Provisional; Region: PRK13578 573235011046 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 573235011047 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 573235011048 homodimer interface [polypeptide binding]; other site 573235011049 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573235011050 catalytic residue [active] 573235011051 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 573235011052 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 573235011053 Integrative element ECO26_IE07 573235011054 integrase; Provisional; Region: PRK09692 573235011055 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 573235011056 active site 573235011057 Int/Topo IB signature motif; other site 573235011058 Integrative element ECO26_IE07; predicted protein in insertion sequence ISSfl3, C-terminal fragment 573235011059 bifunctional enterobactin receptor/adhesin protein; Provisional; Region: PRK13486 573235011060 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 573235011061 N-terminal plug; other site 573235011062 ligand-binding site [chemical binding]; other site 573235011063 Integrative element ECO26_IE07; predicted protein in insertion sequence IS110/IS492 family IS element, N-terminal fragment 573235011064 putative transposase OrfB; Reviewed; Region: PHA02517 573235011065 HTH-like domain; Region: HTH_21; pfam13276 573235011066 Integrase core domain; Region: rve; pfam00665 573235011067 Integrase core domain; Region: rve_3; pfam13683 573235011068 Transposase; Region: HTH_Tnp_1; cl17663 573235011069 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 573235011070 hypothetical protein; Provisional; Region: PRK10649 573235011071 Sulfatase; Region: Sulfatase; pfam00884 573235011072 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 573235011073 active site 573235011074 hypothetical protein; Provisional; Region: PRK09732 573235011075 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 573235011076 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 573235011077 Cysteine-rich domain; Region: CCG; pfam02754 573235011078 Cysteine-rich domain; Region: CCG; pfam02754 573235011079 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 573235011080 FAD binding domain; Region: FAD_binding_4; pfam01565 573235011081 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 573235011082 FAD binding domain; Region: FAD_binding_4; pfam01565 573235011083 DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990 573235011084 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573235011085 DNA-binding site [nucleotide binding]; DNA binding site 573235011086 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 573235011087 acyl-CoA synthetase; Validated; Region: PRK09192 573235011088 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 573235011089 acyl-activating enzyme (AAE) consensus motif; other site 573235011090 active site 573235011091 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 573235011092 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573235011093 NAD(P) binding site [chemical binding]; other site 573235011094 active site 573235011095 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 573235011096 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 573235011097 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 573235011098 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 573235011099 catalytic residue [active] 573235011100 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 573235011101 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 573235011102 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 573235011103 Predicted permeases [General function prediction only]; Region: COG0795 573235011104 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; pfam09695 573235011105 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 573235011106 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 573235011107 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 573235011108 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 573235011109 active site 573235011110 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 573235011111 TMP-binding site; other site 573235011112 ATP-binding site [chemical binding]; other site 573235011113 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 573235011114 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 573235011115 TMP-binding site; other site 573235011116 ATP-binding site [chemical binding]; other site 573235011117 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 573235011118 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 573235011119 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 573235011120 CHAP domain; Region: CHAP; pfam05257 573235011121 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 573235011122 putative S-transferase; Provisional; Region: PRK11752 573235011123 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 573235011124 C-terminal domain interface [polypeptide binding]; other site 573235011125 GSH binding site (G-site) [chemical binding]; other site 573235011126 dimer interface [polypeptide binding]; other site 573235011127 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 573235011128 dimer interface [polypeptide binding]; other site 573235011129 N-terminal domain interface [polypeptide binding]; other site 573235011130 active site 573235011131 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 573235011132 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 573235011133 hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380 573235011134 hydrogenase 2-specific chaperone; Provisional; Region: PRK10465 573235011135 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 573235011136 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 573235011137 putative substrate-binding site; other site 573235011138 nickel binding site [ion binding]; other site 573235011139 hydrogenase 2 large subunit; Provisional; Region: PRK10467 573235011140 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 573235011141 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 573235011142 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 573235011143 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 573235011144 4Fe-4S binding domain; Region: Fer4_6; pfam12837 573235011145 hydrogenase 2 small subunit; Provisional; Region: PRK10468 573235011146 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 573235011147 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 573235011148 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 573235011149 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 573235011150 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 573235011151 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 573235011152 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 573235011153 active site 573235011154 catalytic tetrad [active] 573235011155 hypothetical protein; Provisional; Region: PRK05208 573235011156 oxidoreductase; Provisional; Region: PRK07985 573235011157 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 573235011158 NAD binding site [chemical binding]; other site 573235011159 metal binding site [ion binding]; metal-binding site 573235011160 active site 573235011161 biopolymer transport protein ExbD; Provisional; Region: PRK11267 573235011162 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 573235011163 biopolymer transport protein ExbB; Provisional; Region: PRK10414 573235011164 cystathionine beta-lyase; Provisional; Region: PRK08114 573235011165 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 573235011166 homodimer interface [polypeptide binding]; other site 573235011167 substrate-cofactor binding pocket; other site 573235011168 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573235011169 catalytic residue [active] 573235011170 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 573235011171 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 573235011172 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 573235011173 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 573235011174 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573235011175 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573235011176 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 573235011177 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 573235011178 dimer interface [polypeptide binding]; other site 573235011179 active site 573235011180 metal binding site [ion binding]; metal-binding site 573235011181 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 573235011182 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 573235011183 active site 573235011184 catalytic tetrad [active] 573235011185 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 573235011186 putative outer membrane lipoprotein; Provisional; Region: PRK09973 573235011187 hypothetical protein; Provisional; Region: PRK01254 573235011188 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 573235011189 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 573235011190 FtsI repressor; Provisional; Region: PRK10883 573235011191 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 573235011192 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 573235011193 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 573235011194 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 573235011195 putative acyl-acceptor binding pocket; other site 573235011196 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 573235011197 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 573235011198 CAP-like domain; other site 573235011199 active site 573235011200 primary dimer interface [polypeptide binding]; other site 573235011201 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 573235011202 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 573235011203 TIGR00156 family protein; Region: TIGR00156 573235011204 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 573235011205 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573235011206 active site 573235011207 phosphorylation site [posttranslational modification] 573235011208 intermolecular recognition site; other site 573235011209 dimerization interface [polypeptide binding]; other site 573235011210 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573235011211 DNA binding site [nucleotide binding] 573235011212 sensor protein QseC; Provisional; Region: PRK10337 573235011213 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573235011214 dimer interface [polypeptide binding]; other site 573235011215 phosphorylation site [posttranslational modification] 573235011216 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573235011217 ATP binding site [chemical binding]; other site 573235011218 Mg2+ binding site [ion binding]; other site 573235011219 G-X-G motif; other site 573235011220 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 573235011221 Uncharacterized conserved protein [Function unknown]; Region: COG1359 573235011222 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 573235011223 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573235011224 ATP binding site [chemical binding]; other site 573235011225 Mg2+ binding site [ion binding]; other site 573235011226 G-X-G motif; other site 573235011227 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 573235011228 anchoring element; other site 573235011229 dimer interface [polypeptide binding]; other site 573235011230 ATP binding site [chemical binding]; other site 573235011231 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 573235011232 active site 573235011233 metal binding site [ion binding]; metal-binding site 573235011234 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 573235011235 esterase YqiA; Provisional; Region: PRK11071 573235011236 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 573235011237 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 573235011238 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 573235011239 active site 573235011240 metal binding site [ion binding]; metal-binding site 573235011241 hexamer interface [polypeptide binding]; other site 573235011242 putative dehydrogenase; Provisional; Region: PRK11039 573235011243 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 573235011244 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 573235011245 dimer interface [polypeptide binding]; other site 573235011246 ADP-ribose binding site [chemical binding]; other site 573235011247 active site 573235011248 nudix motif; other site 573235011249 metal binding site [ion binding]; metal-binding site 573235011250 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 573235011251 hypothetical protein; Provisional; Region: PRK11653 573235011252 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 573235011253 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 573235011254 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 573235011255 putative active site [active] 573235011256 metal binding site [ion binding]; metal-binding site 573235011257 zinc transporter ZupT; Provisional; Region: PRK04201 573235011258 ZIP Zinc transporter; Region: Zip; pfam02535 573235011259 Protein of unknown function (DUF4051); Region: DUF4051; pfam13260 573235011260 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 573235011261 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 573235011262 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 573235011263 putative fimbrial protein; Provisional; Region: PRK09733 573235011264 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 573235011265 PapC N-terminal domain; Region: PapC_N; pfam13954 573235011266 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 573235011267 PapC C-terminal domain; Region: PapC_C; pfam13953 573235011268 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 573235011269 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 573235011270 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 573235011271 conserved predicted protein, N-terminal fragment 573235011272 conserved predicted protein, C-terminal fragment 573235011273 glycogen synthesis protein GlgS; Provisional; Region: PRK02922 573235011274 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 573235011275 conserved predicted protein, N-terminal fragment 573235011276 conserved predicted protein, C-terminal fragment 573235011277 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 573235011278 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 573235011279 putative ribose interaction site [chemical binding]; other site 573235011280 putative ADP binding site [chemical binding]; other site 573235011281 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 573235011282 active site 573235011283 nucleotide binding site [chemical binding]; other site 573235011284 HIGH motif; other site 573235011285 KMSKS motif; other site 573235011286 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 573235011287 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 573235011288 metal binding triad; other site 573235011289 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 573235011290 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 573235011291 metal binding triad; other site 573235011292 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 573235011293 Uncharacterized conserved protein [Function unknown]; Region: COG3025 573235011294 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 573235011295 putative active site [active] 573235011296 putative metal binding residues [ion binding]; other site 573235011297 signature motif; other site 573235011298 putative triphosphate binding site [ion binding]; other site 573235011299 CHAD domain; Region: CHAD; pfam05235 573235011300 SH3 domain-containing protein; Provisional; Region: PRK10884 573235011301 Bacterial SH3 domain homologues; Region: SH3b; smart00287 573235011302 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 573235011303 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 573235011304 active site 573235011305 NTP binding site [chemical binding]; other site 573235011306 metal binding triad [ion binding]; metal-binding site 573235011307 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 573235011308 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573235011309 Zn2+ binding site [ion binding]; other site 573235011310 Mg2+ binding site [ion binding]; other site 573235011311 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 573235011312 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 573235011313 homooctamer interface [polypeptide binding]; other site 573235011314 active site 573235011315 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 573235011316 transcriptional activator TtdR; Provisional; Region: PRK09801 573235011317 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573235011318 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 573235011319 putative effector binding pocket; other site 573235011320 putative dimerization interface [polypeptide binding]; other site 573235011321 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 573235011322 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 573235011323 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 573235011324 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 573235011325 transmembrane helices; other site 573235011326 UGMP family protein; Validated; Region: PRK09604 573235011327 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 573235011328 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 573235011329 DNA primase; Validated; Region: dnaG; PRK05667 573235011330 CHC2 zinc finger; Region: zf-CHC2; pfam01807 573235011331 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 573235011332 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 573235011333 active site 573235011334 metal binding site [ion binding]; metal-binding site 573235011335 interdomain interaction site; other site 573235011336 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 573235011337 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 573235011338 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 573235011339 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 573235011340 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 573235011341 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 573235011342 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573235011343 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 573235011344 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573235011345 DNA binding residues [nucleotide binding] 573235011346 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 573235011347 active site 573235011348 SUMO-1 interface [polypeptide binding]; other site 573235011349 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 573235011350 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 573235011351 FAD binding pocket [chemical binding]; other site 573235011352 FAD binding motif [chemical binding]; other site 573235011353 phosphate binding motif [ion binding]; other site 573235011354 NAD binding pocket [chemical binding]; other site 573235011355 Predicted transcriptional regulators [Transcription]; Region: COG1695 573235011356 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 573235011357 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573235011358 PAS fold; Region: PAS_3; pfam08447 573235011359 putative active site [active] 573235011360 heme pocket [chemical binding]; other site 573235011361 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 573235011362 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573235011363 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573235011364 dimer interface [polypeptide binding]; other site 573235011365 putative CheW interface [polypeptide binding]; other site 573235011366 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 573235011367 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 573235011368 inhibitor-cofactor binding pocket; inhibition site 573235011369 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573235011370 catalytic residue [active] 573235011371 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 573235011372 dimer interface [polypeptide binding]; other site 573235011373 putative tRNA-binding site [nucleotide binding]; other site 573235011374 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 573235011375 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573235011376 DNA binding site [nucleotide binding] 573235011377 domain linker motif; other site 573235011378 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 573235011379 putative dimerization interface [polypeptide binding]; other site 573235011380 putative ligand binding site [chemical binding]; other site 573235011381 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 573235011382 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 573235011383 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 573235011384 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 573235011385 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 573235011386 cryptic beta-D-galactosidase subunit beta; Reviewed; Region: ebgC; PRK10202 573235011387 inner membrane transporter YjeM; Provisional; Region: PRK15238 573235011388 predicted glycosyl hydrolase, N-terminal fragment 573235011389 predicted glycosyl hydrolase, C-terminal fragment 573235011390 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 573235011391 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 573235011392 active site 573235011393 FMN binding site [chemical binding]; other site 573235011394 2,4-decadienoyl-CoA binding site; other site 573235011395 catalytic residue [active] 573235011396 4Fe-4S cluster binding site [ion binding]; other site 573235011397 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 573235011398 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573235011399 non-specific DNA binding site [nucleotide binding]; other site 573235011400 salt bridge; other site 573235011401 sequence-specific DNA binding site [nucleotide binding]; other site 573235011402 conserved predicted protein, C-terminal fragment 573235011403 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 573235011404 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573235011405 S-adenosylmethionine binding site [chemical binding]; other site 573235011406 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 573235011407 predicted thioredoxin, N-terminal fragment 573235011408 predicted thioredoxin, C-terminal fragment 573235011409 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 573235011410 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 573235011411 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 573235011412 serine/threonine transporter SstT; Provisional; Region: PRK13628 573235011413 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 573235011414 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 573235011415 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 573235011416 galactarate dehydratase; Region: galactar-dH20; TIGR03248 573235011417 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 573235011418 Glucuronate isomerase; Region: UxaC; pfam02614 573235011419 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 573235011420 D-galactonate transporter; Region: 2A0114; TIGR00893 573235011421 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235011422 putative substrate translocation pore; other site 573235011423 CblD like pilus biogenesis initiator; Region: CblD; cl06460 573235011424 fimbrial outer membrane usher protein TcfC; Provisional; Region: PRK15310 573235011425 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 573235011426 CS1 type fimbrial major subunit; Region: Fimbrial_CS1; pfam04449 573235011427 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 573235011428 putative fimbrial protein TcfA; Provisional; Region: PRK15308 573235011429 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 573235011430 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573235011431 DNA-binding site [nucleotide binding]; DNA binding site 573235011432 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 573235011433 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 573235011434 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 573235011435 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 573235011436 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 573235011437 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 573235011438 Predicted membrane protein [Function unknown]; Region: COG5393 573235011439 YqjK-like protein; Region: YqjK; pfam13997 573235011440 Predicted membrane protein [Function unknown]; Region: COG2259 573235011441 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 573235011442 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 573235011443 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 573235011444 putative dimer interface [polypeptide binding]; other site 573235011445 N-terminal domain interface [polypeptide binding]; other site 573235011446 putative substrate binding pocket (H-site) [chemical binding]; other site 573235011447 Predicted membrane protein [Function unknown]; Region: COG3152 573235011448 Protein of unknown function (DUF805); Region: DUF805; pfam05656 573235011449 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573235011450 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 573235011451 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 573235011452 dimerization interface [polypeptide binding]; other site 573235011453 Pirin-related protein [General function prediction only]; Region: COG1741 573235011454 Pirin; Region: Pirin; pfam02678 573235011455 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 573235011456 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 573235011457 serine transporter; Region: stp; TIGR00814 573235011458 L-serine dehydratase TdcG; Provisional; Region: PRK15040 573235011459 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 573235011460 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 573235011461 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 573235011462 homotrimer interaction site [polypeptide binding]; other site 573235011463 putative active site [active] 573235011464 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 573235011465 Pyruvate formate lyase 1; Region: PFL1; cd01678 573235011466 coenzyme A binding site [chemical binding]; other site 573235011467 active site 573235011468 catalytic residues [active] 573235011469 glycine loop; other site 573235011470 propionate/acetate kinase; Provisional; Region: PRK12379 573235011471 Acetokinase family; Region: Acetate_kinase; cl17229 573235011472 threonine/serine transporter TdcC; Provisional; Region: PRK13629 573235011473 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 573235011474 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 573235011475 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 573235011476 tetramer interface [polypeptide binding]; other site 573235011477 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573235011478 catalytic residue [active] 573235011479 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 573235011480 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573235011481 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 573235011482 putative substrate binding pocket [chemical binding]; other site 573235011483 putative dimerization interface [polypeptide binding]; other site 573235011484 DNA-binding transcriptional activator TdcR; Provisional; Region: PRK11424 573235011485 hypothetical protein; Provisional; Region: PRK09716 573235011486 glycerate kinase I; Provisional; Region: PRK10342 573235011487 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 573235011488 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 573235011489 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 573235011490 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235011491 D-galactonate transporter; Region: 2A0114; TIGR00893 573235011492 putative substrate translocation pore; other site 573235011493 galactarate dehydratase; Region: galactar-dH20; TIGR03248 573235011494 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 573235011495 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 573235011496 putative regulator PrlF; Provisional; Region: PRK09974 573235011497 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 573235011498 Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663 573235011499 DNA-binding transcriptional regulator AgaR; Provisional; Region: PRK09802 573235011500 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 573235011501 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 573235011502 tagatose 6-phosphate aldolase subunit KbaZ; Provisional; Region: PRK15458 573235011503 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 573235011504 active site 573235011505 phosphorylation site [posttranslational modification] 573235011506 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 573235011507 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 573235011508 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 573235011509 active pocket/dimerization site; other site 573235011510 active site 573235011511 phosphorylation site [posttranslational modification] 573235011512 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 573235011513 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 573235011514 active site 573235011515 dimer interface [polypeptide binding]; other site 573235011516 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 573235011517 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 573235011518 dimer interface [polypeptide binding]; other site 573235011519 active site 573235011520 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 573235011521 putative active site [active] 573235011522 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cd00453 573235011523 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 573235011524 active site 573235011525 intersubunit interface [polypeptide binding]; other site 573235011526 zinc binding site [ion binding]; other site 573235011527 Na+ binding site [ion binding]; other site 573235011528 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 573235011529 active site 573235011530 phosphorylation site [posttranslational modification] 573235011531 PTS system N-acetylgalactosamine-specific transporter subunit IIC; Provisional; Region: PRK09757 573235011532 PTS system N-acetylgalactosamine-specific transporter subunit IID; Provisional; Region: PRK09855 573235011533 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 573235011534 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 573235011535 active site 573235011536 trimer interface [polypeptide binding]; other site 573235011537 allosteric site; other site 573235011538 active site lid [active] 573235011539 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 573235011540 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 573235011541 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 573235011542 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 573235011543 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 573235011544 PapC N-terminal domain; Region: PapC_N; pfam13954 573235011545 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 573235011546 PapC C-terminal domain; Region: PapC_C; pfam13953 573235011547 Fimbrial protein; Region: Fimbrial; pfam00419 573235011548 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 573235011549 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 573235011550 putative SAM binding site [chemical binding]; other site 573235011551 putative homodimer interface [polypeptide binding]; other site 573235011552 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 573235011553 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 573235011554 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 573235011555 putative ligand binding site [chemical binding]; other site 573235011556 TIGR00252 family protein; Region: TIGR00252 573235011557 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 573235011558 dimer interface [polypeptide binding]; other site 573235011559 active site 573235011560 outer membrane lipoprotein; Provisional; Region: PRK11023 573235011561 BON domain; Region: BON; pfam04972 573235011562 BON domain; Region: BON; pfam04972 573235011563 Predicted permease; Region: DUF318; pfam03773 573235011564 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 573235011565 NADH(P)-binding; Region: NAD_binding_10; pfam13460 573235011566 NAD binding site [chemical binding]; other site 573235011567 active site 573235011568 intracellular protease, PfpI family; Region: PfpI; TIGR01382 573235011569 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 573235011570 proposed catalytic triad [active] 573235011571 conserved cys residue [active] 573235011572 hypothetical protein; Provisional; Region: PRK03467 573235011573 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 573235011574 GIY-YIG motif/motif A; other site 573235011575 putative active site [active] 573235011576 putative metal binding site [ion binding]; other site 573235011577 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 573235011578 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573235011579 Coenzyme A binding pocket [chemical binding]; other site 573235011580 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 573235011581 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 573235011582 Peptidase family U32; Region: Peptidase_U32; pfam01136 573235011583 putative protease; Provisional; Region: PRK15447 573235011584 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 573235011585 hypothetical protein; Provisional; Region: PRK10508 573235011586 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 573235011587 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 573235011588 Transposase; Region: DEDD_Tnp_IS110; pfam01548 573235011589 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 573235011590 tryptophan permease; Provisional; Region: PRK10483 573235011591 aromatic amino acid transport protein; Region: araaP; TIGR00837 573235011592 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 573235011593 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 573235011594 ATP binding site [chemical binding]; other site 573235011595 Mg++ binding site [ion binding]; other site 573235011596 motif III; other site 573235011597 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573235011598 nucleotide binding region [chemical binding]; other site 573235011599 ATP-binding site [chemical binding]; other site 573235011600 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 573235011601 putative RNA binding site [nucleotide binding]; other site 573235011602 lipoprotein NlpI; Provisional; Region: PRK11189 573235011603 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573235011604 binding surface 573235011605 TPR motif; other site 573235011606 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 573235011607 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 573235011608 RNase E interface [polypeptide binding]; other site 573235011609 trimer interface [polypeptide binding]; other site 573235011610 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 573235011611 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 573235011612 RNase E interface [polypeptide binding]; other site 573235011613 trimer interface [polypeptide binding]; other site 573235011614 active site 573235011615 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 573235011616 putative nucleic acid binding region [nucleotide binding]; other site 573235011617 G-X-X-G motif; other site 573235011618 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 573235011619 RNA binding site [nucleotide binding]; other site 573235011620 domain interface; other site 573235011621 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 573235011622 16S/18S rRNA binding site [nucleotide binding]; other site 573235011623 S13e-L30e interaction site [polypeptide binding]; other site 573235011624 25S rRNA binding site [nucleotide binding]; other site 573235011625 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 573235011626 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 573235011627 RNA binding site [nucleotide binding]; other site 573235011628 active site 573235011629 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 573235011630 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 573235011631 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 573235011632 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 573235011633 translation initiation factor IF-2; Region: IF-2; TIGR00487 573235011634 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 573235011635 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 573235011636 G1 box; other site 573235011637 putative GEF interaction site [polypeptide binding]; other site 573235011638 GTP/Mg2+ binding site [chemical binding]; other site 573235011639 Switch I region; other site 573235011640 G2 box; other site 573235011641 G3 box; other site 573235011642 Switch II region; other site 573235011643 G4 box; other site 573235011644 G5 box; other site 573235011645 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 573235011646 Translation-initiation factor 2; Region: IF-2; pfam11987 573235011647 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 573235011648 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 573235011649 NusA N-terminal domain; Region: NusA_N; pfam08529 573235011650 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 573235011651 RNA binding site [nucleotide binding]; other site 573235011652 homodimer interface [polypeptide binding]; other site 573235011653 NusA-like KH domain; Region: KH_5; pfam13184 573235011654 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 573235011655 G-X-X-G motif; other site 573235011656 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 573235011657 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 573235011658 ribosome maturation protein RimP; Reviewed; Region: PRK00092 573235011659 hypothetical protein; Provisional; Region: PRK14641 573235011660 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 573235011661 putative oligomer interface [polypeptide binding]; other site 573235011662 putative RNA binding site [nucleotide binding]; other site 573235011663 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 573235011664 ANP binding site [chemical binding]; other site 573235011665 Substrate Binding Site II [chemical binding]; other site 573235011666 Substrate Binding Site I [chemical binding]; other site 573235011667 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 573235011668 Sulfatase; Region: Sulfatase; pfam00884 573235011669 Preprotein translocase SecG subunit; Region: SecG; pfam03840 573235011670 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 573235011671 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 573235011672 active site 573235011673 substrate binding site [chemical binding]; other site 573235011674 metal binding site [ion binding]; metal-binding site 573235011675 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 573235011676 dihydropteroate synthase; Region: DHPS; TIGR01496 573235011677 substrate binding pocket [chemical binding]; other site 573235011678 dimer interface [polypeptide binding]; other site 573235011679 inhibitor binding site; inhibition site 573235011680 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 573235011681 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573235011682 Walker A motif; other site 573235011683 ATP binding site [chemical binding]; other site 573235011684 Walker B motif; other site 573235011685 arginine finger; other site 573235011686 Peptidase family M41; Region: Peptidase_M41; pfam01434 573235011687 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 573235011688 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573235011689 S-adenosylmethionine binding site [chemical binding]; other site 573235011690 RNA-binding protein YhbY; Provisional; Region: PRK10343 573235011691 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 573235011692 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 573235011693 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 573235011694 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 573235011695 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 573235011696 GTPase CgtA; Reviewed; Region: obgE; PRK12298 573235011697 GTP1/OBG; Region: GTP1_OBG; pfam01018 573235011698 Obg GTPase; Region: Obg; cd01898 573235011699 G1 box; other site 573235011700 GTP/Mg2+ binding site [chemical binding]; other site 573235011701 Switch I region; other site 573235011702 G2 box; other site 573235011703 G3 box; other site 573235011704 Switch II region; other site 573235011705 G4 box; other site 573235011706 G5 box; other site 573235011707 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 573235011708 EamA-like transporter family; Region: EamA; pfam00892 573235011709 EamA-like transporter family; Region: EamA; pfam00892 573235011710 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 573235011711 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 573235011712 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 573235011713 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 573235011714 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 573235011715 substrate binding pocket [chemical binding]; other site 573235011716 chain length determination region; other site 573235011717 substrate-Mg2+ binding site; other site 573235011718 catalytic residues [active] 573235011719 aspartate-rich region 1; other site 573235011720 active site lid residues [active] 573235011721 aspartate-rich region 2; other site 573235011722 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 573235011723 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 573235011724 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 573235011725 hinge; other site 573235011726 active site 573235011727 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 573235011728 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 573235011729 anti sigma factor interaction site; other site 573235011730 regulatory phosphorylation site [posttranslational modification]; other site 573235011731 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 573235011732 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 573235011733 mce related protein; Region: MCE; pfam02470 573235011734 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 573235011735 conserved hypothetical integral membrane protein; Region: TIGR00056 573235011736 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 573235011737 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 573235011738 Walker A/P-loop; other site 573235011739 ATP binding site [chemical binding]; other site 573235011740 Q-loop/lid; other site 573235011741 ABC transporter signature motif; other site 573235011742 Walker B; other site 573235011743 D-loop; other site 573235011744 H-loop/switch region; other site 573235011745 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 573235011746 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 573235011747 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 573235011748 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 573235011749 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 573235011750 putative active site [active] 573235011751 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 573235011752 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 573235011753 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 573235011754 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 573235011755 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 573235011756 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 573235011757 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 573235011758 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 573235011759 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 573235011760 Walker A/P-loop; other site 573235011761 ATP binding site [chemical binding]; other site 573235011762 Q-loop/lid; other site 573235011763 ABC transporter signature motif; other site 573235011764 Walker B; other site 573235011765 D-loop; other site 573235011766 H-loop/switch region; other site 573235011767 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 573235011768 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 573235011769 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 573235011770 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 573235011771 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 573235011772 30S subunit binding site; other site 573235011773 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 573235011774 active site 573235011775 phosphorylation site [posttranslational modification] 573235011776 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 573235011777 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 573235011778 dimerization domain swap beta strand [polypeptide binding]; other site 573235011779 regulatory protein interface [polypeptide binding]; other site 573235011780 active site 573235011781 regulatory phosphorylation site [posttranslational modification]; other site 573235011782 hypothetical protein; Provisional; Region: PRK10345 573235011783 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 573235011784 Transglycosylase; Region: Transgly; cl17702 573235011785 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 573235011786 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 573235011787 conserved cys residue [active] 573235011788 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 573235011789 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573235011790 putative active site [active] 573235011791 heme pocket [chemical binding]; other site 573235011792 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573235011793 dimer interface [polypeptide binding]; other site 573235011794 phosphorylation site [posttranslational modification] 573235011795 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573235011796 ATP binding site [chemical binding]; other site 573235011797 Mg2+ binding site [ion binding]; other site 573235011798 G-X-G motif; other site 573235011799 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573235011800 active site 573235011801 phosphorylation site [posttranslational modification] 573235011802 intermolecular recognition site; other site 573235011803 dimerization interface [polypeptide binding]; other site 573235011804 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 573235011805 putative binding surface; other site 573235011806 active site 573235011807 radical SAM protein, TIGR01212 family; Region: TIGR01212 573235011808 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573235011809 FeS/SAM binding site; other site 573235011810 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 573235011811 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 573235011812 active site 573235011813 dimer interface [polypeptide binding]; other site 573235011814 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 573235011815 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 573235011816 active site 573235011817 FMN binding site [chemical binding]; other site 573235011818 substrate binding site [chemical binding]; other site 573235011819 3Fe-4S cluster binding site [ion binding]; other site 573235011820 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 573235011821 domain interface; other site 573235011822 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 573235011823 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 573235011824 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 573235011825 conserved predicted protein, N-terminal fragment 573235011826 conserved predicted protein, C-terminal fragment 573235011827 uncharacterized protein, YhcH/YjgK/YiaL family; Region: TIGR00022 573235011828 N-acetylmannosamine kinase; Provisional; Region: PRK05082 573235011829 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 573235011830 nucleotide binding site [chemical binding]; other site 573235011831 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 573235011832 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 573235011833 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 573235011834 putative active site cavity [active] 573235011835 putative sialic acid transporter; Provisional; Region: PRK03893 573235011836 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235011837 putative substrate translocation pore; other site 573235011838 N-acetylneuraminate lyase; Region: nanA; TIGR00683 573235011839 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 573235011840 inhibitor site; inhibition site 573235011841 active site 573235011842 dimer interface [polypeptide binding]; other site 573235011843 catalytic residue [active] 573235011844 transcriptional regulator NanR; Provisional; Region: PRK03837 573235011845 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573235011846 DNA-binding site [nucleotide binding]; DNA binding site 573235011847 FCD domain; Region: FCD; pfam07729 573235011848 putative cryptic C4-dicarboxylate transporter DcuD; Provisional; Region: PRK09804 573235011849 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 573235011850 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 573235011851 stringent starvation protein A; Provisional; Region: sspA; PRK09481 573235011852 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 573235011853 C-terminal domain interface [polypeptide binding]; other site 573235011854 putative GSH binding site (G-site) [chemical binding]; other site 573235011855 dimer interface [polypeptide binding]; other site 573235011856 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 573235011857 dimer interface [polypeptide binding]; other site 573235011858 N-terminal domain interface [polypeptide binding]; other site 573235011859 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 573235011860 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 573235011861 23S rRNA interface [nucleotide binding]; other site 573235011862 L3 interface [polypeptide binding]; other site 573235011863 Predicted ATPase [General function prediction only]; Region: COG1485 573235011864 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 573235011865 hypothetical protein; Provisional; Region: PRK11677 573235011866 serine endoprotease; Provisional; Region: PRK10139 573235011867 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 573235011868 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 573235011869 protein binding site [polypeptide binding]; other site 573235011870 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 573235011871 serine endoprotease; Provisional; Region: PRK10898 573235011872 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 573235011873 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 573235011874 malate dehydrogenase; Provisional; Region: PRK05086 573235011875 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 573235011876 NAD binding site [chemical binding]; other site 573235011877 dimerization interface [polypeptide binding]; other site 573235011878 Substrate binding site [chemical binding]; other site 573235011879 arginine repressor; Provisional; Region: PRK05066 573235011880 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 573235011881 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 573235011882 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 573235011883 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 573235011884 RNAase interaction site [polypeptide binding]; other site 573235011885 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 573235011886 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 573235011887 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 573235011888 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 573235011889 HlyD family secretion protein; Region: HlyD_3; pfam13437 573235011890 efflux system membrane protein; Provisional; Region: PRK11594 573235011891 transcriptional regulator; Provisional; Region: PRK10632 573235011892 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573235011893 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 573235011894 putative effector binding pocket; other site 573235011895 dimerization interface [polypeptide binding]; other site 573235011896 protease TldD; Provisional; Region: tldD; PRK10735 573235011897 hypothetical protein; Provisional; Region: PRK10899 573235011898 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 573235011899 ribonuclease G; Provisional; Region: PRK11712 573235011900 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 573235011901 homodimer interface [polypeptide binding]; other site 573235011902 oligonucleotide binding site [chemical binding]; other site 573235011903 Maf-like protein; Region: Maf; pfam02545 573235011904 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 573235011905 active site 573235011906 dimer interface [polypeptide binding]; other site 573235011907 rod shape-determining protein MreD; Provisional; Region: PRK11060 573235011908 rod shape-determining protein MreC; Region: mreC; TIGR00219 573235011909 rod shape-determining protein MreC; Region: MreC; pfam04085 573235011910 rod shape-determining protein MreB; Provisional; Region: PRK13927 573235011911 MreB and similar proteins; Region: MreB_like; cd10225 573235011912 nucleotide binding site [chemical binding]; other site 573235011913 Mg binding site [ion binding]; other site 573235011914 putative protofilament interaction site [polypeptide binding]; other site 573235011915 RodZ interaction site [polypeptide binding]; other site 573235011916 regulatory protein CsrD; Provisional; Region: PRK11059 573235011917 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573235011918 metal binding site [ion binding]; metal-binding site 573235011919 active site 573235011920 I-site; other site 573235011921 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 573235011922 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 573235011923 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 573235011924 NADP binding site [chemical binding]; other site 573235011925 dimer interface [polypeptide binding]; other site 573235011926 Protein of unknown function (DUF1444); Region: DUF1444; cl02011 573235011927 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 573235011928 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 573235011929 carboxyltransferase (CT) interaction site; other site 573235011930 biotinylation site [posttranslational modification]; other site 573235011931 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 573235011932 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 573235011933 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 573235011934 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 573235011935 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 573235011936 active site 573235011937 catalytic residues [active] 573235011938 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 573235011939 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 573235011940 substrate binding site [chemical binding]; other site 573235011941 ATP binding site [chemical binding]; other site 573235011942 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573235011943 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 573235011944 TM-ABC transporter signature motif; other site 573235011945 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 573235011946 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 573235011947 Walker A/P-loop; other site 573235011948 ATP binding site [chemical binding]; other site 573235011949 Q-loop/lid; other site 573235011950 ABC transporter signature motif; other site 573235011951 Walker B; other site 573235011952 D-loop; other site 573235011953 H-loop/switch region; other site 573235011954 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 573235011955 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 573235011956 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_12; cd06322 573235011957 putative ligand binding site [chemical binding]; other site 573235011958 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 573235011959 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 573235011960 intersubunit interface [polypeptide binding]; other site 573235011961 active site 573235011962 zinc binding site [ion binding]; other site 573235011963 Na+ binding site [ion binding]; other site 573235011964 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 573235011965 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 573235011966 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 573235011967 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 573235011968 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 573235011969 substrate binding site [chemical binding]; other site 573235011970 ATP binding site [chemical binding]; other site 573235011971 hypothetical protein; Provisional; Region: PRK10633 573235011972 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 573235011973 Na binding site [ion binding]; other site 573235011974 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 573235011975 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 573235011976 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 573235011977 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 573235011978 FMN binding site [chemical binding]; other site 573235011979 active site 573235011980 catalytic residues [active] 573235011981 substrate binding site [chemical binding]; other site 573235011982 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 573235011983 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 573235011984 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 573235011985 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573235011986 DNA methylase; Region: N6_N4_Mtase; pfam01555 573235011987 Protein of unknown function (DUF2556); Region: DUF2556; pfam10831 573235011988 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 573235011989 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573235011990 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 573235011991 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 573235011992 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 573235011993 HlyD family secretion protein; Region: HlyD_3; pfam13437 573235011994 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 573235011995 Protein export membrane protein; Region: SecD_SecF; cl14618 573235011996 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 573235011997 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 573235011998 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 573235011999 substrate binding pocket [chemical binding]; other site 573235012000 membrane-bound complex binding site; other site 573235012001 hinge residues; other site 573235012002 transport system permease protein; membrane component of ABC superfamily, N-terminal fragment 573235012003 Transposase; Region: HTH_Tnp_1; cl17663 573235012004 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 573235012005 putative transposase OrfB; Reviewed; Region: PHA02517 573235012006 HTH-like domain; Region: HTH_21; pfam13276 573235012007 Integrase core domain; Region: rve; pfam00665 573235012008 Integrase core domain; Region: rve_3; pfam13683 573235012009 transport system permease protein; membrane component of ABC superfamily, C-terminal fragment 573235012010 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 573235012011 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573235012012 dimer interface [polypeptide binding]; other site 573235012013 conserved gate region; other site 573235012014 putative PBP binding loops; other site 573235012015 ABC-ATPase subunit interface; other site 573235012016 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 573235012017 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 573235012018 Walker A/P-loop; other site 573235012019 ATP binding site [chemical binding]; other site 573235012020 Q-loop/lid; other site 573235012021 ABC transporter signature motif; other site 573235012022 Walker B; other site 573235012023 D-loop; other site 573235012024 H-loop/switch region; other site 573235012025 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 573235012026 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 573235012027 trimer interface [polypeptide binding]; other site 573235012028 putative metal binding site [ion binding]; other site 573235012029 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 573235012030 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 573235012031 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 573235012032 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 573235012033 shikimate binding site; other site 573235012034 NAD(P) binding site [chemical binding]; other site 573235012035 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 573235012036 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 573235012037 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 573235012038 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 573235012039 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 573235012040 hypothetical protein; Validated; Region: PRK03430 573235012041 hypothetical protein; Provisional; Region: PRK10736 573235012042 DNA protecting protein DprA; Region: dprA; TIGR00732 573235012043 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 573235012044 active site 573235012045 catalytic residues [active] 573235012046 metal binding site [ion binding]; metal-binding site 573235012047 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 573235012048 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 573235012049 putative active site [active] 573235012050 substrate binding site [chemical binding]; other site 573235012051 putative cosubstrate binding site; other site 573235012052 catalytic site [active] 573235012053 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 573235012054 substrate binding site [chemical binding]; other site 573235012055 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 573235012056 putative RNA binding site [nucleotide binding]; other site 573235012057 16S rRNA methyltransferase B; Provisional; Region: PRK10901 573235012058 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573235012059 S-adenosylmethionine binding site [chemical binding]; other site 573235012060 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 573235012061 TrkA-N domain; Region: TrkA_N; pfam02254 573235012062 TrkA-C domain; Region: TrkA_C; pfam02080 573235012063 TrkA-N domain; Region: TrkA_N; pfam02254 573235012064 TrkA-C domain; Region: TrkA_C; pfam02080 573235012065 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 573235012066 Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741 573235012067 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 573235012068 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 573235012069 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 573235012070 DNA binding residues [nucleotide binding] 573235012071 dimer interface [polypeptide binding]; other site 573235012072 metal binding site [ion binding]; metal-binding site 573235012073 hypothetical protein; Provisional; Region: PRK10203 573235012074 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 573235012075 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 573235012076 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 573235012077 alphaNTD homodimer interface [polypeptide binding]; other site 573235012078 alphaNTD - beta interaction site [polypeptide binding]; other site 573235012079 alphaNTD - beta' interaction site [polypeptide binding]; other site 573235012080 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 573235012081 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 573235012082 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 573235012083 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 573235012084 RNA binding surface [nucleotide binding]; other site 573235012085 30S ribosomal protein S11; Validated; Region: PRK05309 573235012086 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 573235012087 30S ribosomal protein S13; Region: bact_S13; TIGR03631 573235012088 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 573235012089 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 573235012090 SecY translocase; Region: SecY; pfam00344 573235012091 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 573235012092 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 573235012093 23S rRNA binding site [nucleotide binding]; other site 573235012094 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 573235012095 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 573235012096 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 573235012097 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 573235012098 23S rRNA interface [nucleotide binding]; other site 573235012099 5S rRNA interface [nucleotide binding]; other site 573235012100 L27 interface [polypeptide binding]; other site 573235012101 L5 interface [polypeptide binding]; other site 573235012102 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 573235012103 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 573235012104 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 573235012105 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 573235012106 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 573235012107 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 573235012108 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 573235012109 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 573235012110 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 573235012111 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 573235012112 RNA binding site [nucleotide binding]; other site 573235012113 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 573235012114 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 573235012115 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 573235012116 23S rRNA interface [nucleotide binding]; other site 573235012117 putative translocon interaction site; other site 573235012118 signal recognition particle (SRP54) interaction site; other site 573235012119 L23 interface [polypeptide binding]; other site 573235012120 trigger factor interaction site; other site 573235012121 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 573235012122 23S rRNA interface [nucleotide binding]; other site 573235012123 5S rRNA interface [nucleotide binding]; other site 573235012124 putative antibiotic binding site [chemical binding]; other site 573235012125 L25 interface [polypeptide binding]; other site 573235012126 L27 interface [polypeptide binding]; other site 573235012127 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 573235012128 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 573235012129 G-X-X-G motif; other site 573235012130 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 573235012131 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 573235012132 protein-rRNA interface [nucleotide binding]; other site 573235012133 putative translocon binding site; other site 573235012134 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 573235012135 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 573235012136 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 573235012137 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 573235012138 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 573235012139 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 573235012140 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 573235012141 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 573235012142 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 573235012143 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 573235012144 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 573235012145 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 573235012146 heme binding site [chemical binding]; other site 573235012147 ferroxidase pore; other site 573235012148 ferroxidase diiron center [ion binding]; other site 573235012149 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 573235012150 elongation factor Tu; Reviewed; Region: PRK00049 573235012151 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 573235012152 G1 box; other site 573235012153 GEF interaction site [polypeptide binding]; other site 573235012154 GTP/Mg2+ binding site [chemical binding]; other site 573235012155 Switch I region; other site 573235012156 G2 box; other site 573235012157 G3 box; other site 573235012158 Switch II region; other site 573235012159 G4 box; other site 573235012160 G5 box; other site 573235012161 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 573235012162 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 573235012163 Antibiotic Binding Site [chemical binding]; other site 573235012164 elongation factor G; Reviewed; Region: PRK00007 573235012165 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 573235012166 G1 box; other site 573235012167 putative GEF interaction site [polypeptide binding]; other site 573235012168 GTP/Mg2+ binding site [chemical binding]; other site 573235012169 Switch I region; other site 573235012170 G2 box; other site 573235012171 G3 box; other site 573235012172 Switch II region; other site 573235012173 G4 box; other site 573235012174 G5 box; other site 573235012175 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 573235012176 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 573235012177 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 573235012178 30S ribosomal protein S7; Validated; Region: PRK05302 573235012179 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 573235012180 S17 interaction site [polypeptide binding]; other site 573235012181 S8 interaction site; other site 573235012182 16S rRNA interaction site [nucleotide binding]; other site 573235012183 streptomycin interaction site [chemical binding]; other site 573235012184 23S rRNA interaction site [nucleotide binding]; other site 573235012185 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 573235012186 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 573235012187 sulfur relay protein TusC; Validated; Region: PRK00211 573235012188 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 573235012189 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 573235012190 YheO-like PAS domain; Region: PAS_6; pfam08348 573235012191 HTH domain; Region: HTH_22; pfam13309 573235012192 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 573235012193 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 573235012194 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 573235012195 phi X174 lysis protein; Provisional; Region: PRK02793 573235012196 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 573235012197 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 573235012198 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 573235012199 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 573235012200 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 573235012201 TrkA-N domain; Region: TrkA_N; pfam02254 573235012202 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 573235012203 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 573235012204 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573235012205 Walker A/P-loop; other site 573235012206 ATP binding site [chemical binding]; other site 573235012207 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 573235012208 ABC transporter signature motif; other site 573235012209 Walker B; other site 573235012210 D-loop; other site 573235012211 ABC transporter; Region: ABC_tran_2; pfam12848 573235012212 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 573235012213 putative hydrolase; Provisional; Region: PRK10985 573235012214 hypothetical protein; Provisional; Region: PRK04966 573235012215 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 573235012216 active site 573235012217 hypothetical protein; Provisional; Region: PRK10738 573235012218 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 573235012219 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 573235012220 ligand binding site [chemical binding]; other site 573235012221 flexible hinge region; other site 573235012222 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 573235012223 putative switch regulator; other site 573235012224 non-specific DNA interactions [nucleotide binding]; other site 573235012225 DNA binding site [nucleotide binding] 573235012226 sequence specific DNA binding site [nucleotide binding]; other site 573235012227 putative cAMP binding site [chemical binding]; other site 573235012228 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 573235012229 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 573235012230 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 573235012231 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 573235012232 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 573235012233 inhibitor-cofactor binding pocket; inhibition site 573235012234 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573235012235 catalytic residue [active] 573235012236 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 573235012237 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 573235012238 glutamine binding [chemical binding]; other site 573235012239 catalytic triad [active] 573235012240 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 573235012241 cell filamentation protein Fic; Provisional; Region: PRK10347 573235012242 hypothetical protein; Provisional; Region: PRK10204 573235012243 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 573235012244 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 573235012245 substrate binding site [chemical binding]; other site 573235012246 putative transporter; Provisional; Region: PRK03699 573235012247 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235012248 putative substrate translocation pore; other site 573235012249 nitrite reductase subunit NirD; Provisional; Region: PRK14989 573235012250 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 573235012251 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 573235012252 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 573235012253 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 573235012254 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 573235012255 nitrite transporter NirC; Provisional; Region: PRK11562 573235012256 siroheme synthase; Provisional; Region: cysG; PRK10637 573235012257 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 573235012258 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 573235012259 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 573235012260 active site 573235012261 SAM binding site [chemical binding]; other site 573235012262 homodimer interface [polypeptide binding]; other site 573235012263 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 573235012264 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 573235012265 hypothetical protein; Provisional; Region: PHA02764 573235012266 fructoselysine-6-P-deglycase; Provisional; Region: frlB; PRK11382 573235012267 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 573235012268 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 573235012269 dimer interface [polypeptide binding]; other site 573235012270 active site 573235012271 fructoselysine 3-epimerase; Provisional; Region: PRK09856 573235012272 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 573235012273 AP (apurinic/apyrimidinic) site pocket; other site 573235012274 DNA interaction; other site 573235012275 Metal-binding active site; metal-binding site 573235012276 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 573235012277 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 573235012278 substrate binding site [chemical binding]; other site 573235012279 ATP binding site [chemical binding]; other site 573235012280 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 573235012281 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573235012282 DNA-binding site [nucleotide binding]; DNA binding site 573235012283 UTRA domain; Region: UTRA; pfam07702 573235012284 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 573235012285 DNA topoisomerase III, bacteria and conjugative plasmid; Region: topB; TIGR01056 573235012286 Protein of unknown function; Region: YhfT; pfam10797 573235012287 Protein of unknown function DUF2620; Region: DUF2620; pfam10941 573235012288 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 573235012289 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 573235012290 active site 573235012291 substrate binding pocket [chemical binding]; other site 573235012292 homodimer interaction site [polypeptide binding]; other site 573235012293 putative mutase; Provisional; Region: PRK12383 573235012294 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; COG1015 573235012295 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme yhfX; Region: PLPDE_III_yhfX_like; cd06811 573235012296 dimer interface [polypeptide binding]; other site 573235012297 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 573235012298 active site 573235012299 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 573235012300 substrate binding site [chemical binding]; other site 573235012301 catalytic residue [active] 573235012302 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 573235012303 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 573235012304 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 573235012305 active site 573235012306 HIGH motif; other site 573235012307 dimer interface [polypeptide binding]; other site 573235012308 KMSKS motif; other site 573235012309 phosphoglycolate phosphatase; Provisional; Region: PRK13222 573235012310 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573235012311 motif II; other site 573235012312 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 573235012313 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 573235012314 substrate binding site [chemical binding]; other site 573235012315 hexamer interface [polypeptide binding]; other site 573235012316 metal binding site [ion binding]; metal-binding site 573235012317 DNA adenine methylase; Provisional; Region: PRK10904 573235012318 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 573235012319 cell division protein DamX; Validated; Region: PRK10905 573235012320 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 573235012321 active site 573235012322 dimer interface [polypeptide binding]; other site 573235012323 metal binding site [ion binding]; metal-binding site 573235012324 shikimate kinase; Reviewed; Region: aroK; PRK00131 573235012325 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 573235012326 ADP binding site [chemical binding]; other site 573235012327 magnesium binding site [ion binding]; other site 573235012328 putative shikimate binding site; other site 573235012329 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 573235012330 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 573235012331 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 573235012332 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 573235012333 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 573235012334 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 573235012335 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 573235012336 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 573235012337 Transglycosylase; Region: Transgly; pfam00912 573235012338 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 573235012339 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 573235012340 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 573235012341 ADP-ribose binding site [chemical binding]; other site 573235012342 dimer interface [polypeptide binding]; other site 573235012343 active site 573235012344 nudix motif; other site 573235012345 metal binding site [ion binding]; metal-binding site 573235012346 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 573235012347 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 573235012348 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573235012349 motif II; other site 573235012350 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 573235012351 RNA binding surface [nucleotide binding]; other site 573235012352 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 573235012353 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 573235012354 dimerization interface [polypeptide binding]; other site 573235012355 domain crossover interface; other site 573235012356 redox-dependent activation switch; other site 573235012357 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 573235012358 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 573235012359 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 573235012360 active site 573235012361 substrate-binding site [chemical binding]; other site 573235012362 metal-binding site [ion binding] 573235012363 ATP binding site [chemical binding]; other site 573235012364 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 573235012365 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573235012366 dimerization interface [polypeptide binding]; other site 573235012367 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573235012368 dimer interface [polypeptide binding]; other site 573235012369 phosphorylation site [posttranslational modification] 573235012370 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573235012371 ATP binding site [chemical binding]; other site 573235012372 G-X-G motif; other site 573235012373 osmolarity response regulator; Provisional; Region: ompR; PRK09468 573235012374 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573235012375 active site 573235012376 phosphorylation site [posttranslational modification] 573235012377 intermolecular recognition site; other site 573235012378 dimerization interface [polypeptide binding]; other site 573235012379 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573235012380 DNA binding site [nucleotide binding] 573235012381 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 573235012382 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 573235012383 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 573235012384 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 573235012385 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 573235012386 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 573235012387 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 573235012388 RNA binding site [nucleotide binding]; other site 573235012389 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 573235012390 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 573235012391 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 573235012392 G1 box; other site 573235012393 GTP/Mg2+ binding site [chemical binding]; other site 573235012394 Switch I region; other site 573235012395 G2 box; other site 573235012396 G3 box; other site 573235012397 Switch II region; other site 573235012398 G4 box; other site 573235012399 G5 box; other site 573235012400 Nucleoside recognition; Region: Gate; pfam07670 573235012401 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 573235012402 Nucleoside recognition; Region: Gate; pfam07670 573235012403 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 573235012404 putative transposase; Provisional; Region: PRK09857 573235012405 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 573235012406 carboxylesterase BioH; Provisional; Region: PRK10349 573235012407 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 573235012408 DNA utilization protein GntX; Provisional; Region: PRK11595 573235012409 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 573235012410 active site 573235012411 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 573235012412 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 573235012413 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 573235012414 high-affinity gluconate transporter; Provisional; Region: PRK14984 573235012415 gluconate transporter; Region: gntP; TIGR00791 573235012416 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 573235012417 4-alpha-glucanotransferase; Region: malQ; TIGR00217 573235012418 maltodextrin phosphorylase; Provisional; Region: PRK14985 573235012419 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 573235012420 homodimer interface [polypeptide binding]; other site 573235012421 active site pocket [active] 573235012422 transcriptional regulator MalT; Provisional; Region: PRK04841 573235012423 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573235012424 DNA binding residues [nucleotide binding] 573235012425 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 573235012426 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 573235012427 putative active site [active] 573235012428 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 573235012429 hypothetical protein; Reviewed; Region: PRK09588 573235012430 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 573235012431 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 573235012432 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573235012433 Walker A motif; other site 573235012434 ATP binding site [chemical binding]; other site 573235012435 Walker B motif; other site 573235012436 arginine finger; other site 573235012437 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 573235012438 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 573235012439 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 573235012440 intramembrane serine protease GlpG; Provisional; Region: PRK10907 573235012441 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 573235012442 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 573235012443 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 573235012444 active site residue [active] 573235012445 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 573235012446 hypothetical protein; Provisional; Region: PRK09781; cl08057 573235012447 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 573235012448 glycogen phosphorylase; Provisional; Region: PRK14986 573235012449 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 573235012450 homodimer interface [polypeptide binding]; other site 573235012451 active site pocket [active] 573235012452 glycogen synthase; Provisional; Region: glgA; PRK00654 573235012453 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 573235012454 ADP-binding pocket [chemical binding]; other site 573235012455 homodimer interface [polypeptide binding]; other site 573235012456 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 573235012457 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 573235012458 ligand binding site; other site 573235012459 oligomer interface; other site 573235012460 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 573235012461 sulfate 1 binding site; other site 573235012462 glycogen debranching enzyme; Provisional; Region: PRK03705 573235012463 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 573235012464 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 573235012465 active site 573235012466 catalytic site [active] 573235012467 glycogen branching enzyme; Provisional; Region: PRK05402 573235012468 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 573235012469 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 573235012470 active site 573235012471 catalytic site [active] 573235012472 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 573235012473 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 573235012474 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 573235012475 putative antibiotic transporter; Provisional; Region: PRK10739 573235012476 low affinity gluconate transporter; Provisional; Region: PRK10472 573235012477 gluconate transporter; Region: gntP; TIGR00791 573235012478 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 573235012479 ATP-binding site [chemical binding]; other site 573235012480 Gluconate-6-phosphate binding site [chemical binding]; other site 573235012481 Shikimate kinase; Region: SKI; pfam01202 573235012482 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 573235012483 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573235012484 DNA binding site [nucleotide binding] 573235012485 domain linker motif; other site 573235012486 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 573235012487 putative ligand binding site [chemical binding]; other site 573235012488 putative dimerization interface [polypeptide binding]; other site 573235012489 Pirin-related protein [General function prediction only]; Region: COG1741 573235012490 Pirin; Region: Pirin; pfam02678 573235012491 putative oxidoreductase; Provisional; Region: PRK10206 573235012492 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 573235012493 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 573235012494 putative acetyltransferase YhhY; Provisional; Region: PRK10140 573235012495 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573235012496 Coenzyme A binding pocket [chemical binding]; other site 573235012497 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 573235012498 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 573235012499 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 573235012500 hypothetical protein; Provisional; Region: PRK10350 573235012501 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 573235012502 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 573235012503 putative active site [active] 573235012504 catalytic site [active] 573235012505 putative metal binding site [ion binding]; other site 573235012506 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 573235012507 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 573235012508 Walker A/P-loop; other site 573235012509 ATP binding site [chemical binding]; other site 573235012510 Q-loop/lid; other site 573235012511 ABC transporter signature motif; other site 573235012512 Walker B; other site 573235012513 D-loop; other site 573235012514 H-loop/switch region; other site 573235012515 TOBE domain; Region: TOBE_2; pfam08402 573235012516 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573235012517 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573235012518 dimer interface [polypeptide binding]; other site 573235012519 conserved gate region; other site 573235012520 putative PBP binding loops; other site 573235012521 ABC-ATPase subunit interface; other site 573235012522 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 573235012523 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573235012524 dimer interface [polypeptide binding]; other site 573235012525 conserved gate region; other site 573235012526 putative PBP binding loops; other site 573235012527 ABC-ATPase subunit interface; other site 573235012528 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 573235012529 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 573235012530 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 573235012531 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 573235012532 Walker A/P-loop; other site 573235012533 ATP binding site [chemical binding]; other site 573235012534 Q-loop/lid; other site 573235012535 ABC transporter signature motif; other site 573235012536 Walker B; other site 573235012537 D-loop; other site 573235012538 H-loop/switch region; other site 573235012539 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 573235012540 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 573235012541 Walker A/P-loop; other site 573235012542 ATP binding site [chemical binding]; other site 573235012543 Q-loop/lid; other site 573235012544 ABC transporter signature motif; other site 573235012545 Walker B; other site 573235012546 D-loop; other site 573235012547 H-loop/switch region; other site 573235012548 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 573235012549 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 573235012550 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 573235012551 TM-ABC transporter signature motif; other site 573235012552 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573235012553 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 573235012554 TM-ABC transporter signature motif; other site 573235012555 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 573235012556 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 573235012557 dimerization interface [polypeptide binding]; other site 573235012558 ligand binding site [chemical binding]; other site 573235012559 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 573235012560 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 573235012561 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 573235012562 dimerization interface [polypeptide binding]; other site 573235012563 ligand binding site [chemical binding]; other site 573235012564 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 573235012565 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573235012566 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573235012567 DNA binding residues [nucleotide binding] 573235012568 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 573235012569 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 573235012570 cell division protein FtsE; Provisional; Region: PRK10908 573235012571 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573235012572 Walker A/P-loop; other site 573235012573 ATP binding site [chemical binding]; other site 573235012574 Q-loop/lid; other site 573235012575 ABC transporter signature motif; other site 573235012576 Walker B; other site 573235012577 D-loop; other site 573235012578 H-loop/switch region; other site 573235012579 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 573235012580 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 573235012581 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 573235012582 P loop; other site 573235012583 GTP binding site [chemical binding]; other site 573235012584 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 573235012585 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573235012586 S-adenosylmethionine binding site [chemical binding]; other site 573235012587 hypothetical protein; Provisional; Region: PRK10910 573235012588 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 573235012589 Predicted membrane protein [Function unknown]; Region: COG3714 573235012590 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 573235012591 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 573235012592 metal-binding site [ion binding] 573235012593 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 573235012594 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 573235012595 CPxP motif; other site 573235012596 hypothetical protein; Provisional; Region: PRK11212 573235012597 hypothetical protein; Provisional; Region: PRK11615 573235012598 major facilitator superfamily transporter; Provisional; Region: PRK05122 573235012599 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235012600 putative substrate translocation pore; other site 573235012601 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 573235012602 Domain of unknown function DUF20; Region: UPF0118; pfam01594 573235012603 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 573235012604 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 573235012605 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 573235012606 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 573235012607 substrate binding site [chemical binding]; other site 573235012608 nickel transporter permease NikB; Provisional; Region: PRK10352 573235012609 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573235012610 dimer interface [polypeptide binding]; other site 573235012611 conserved gate region; other site 573235012612 putative PBP binding loops; other site 573235012613 ABC-ATPase subunit interface; other site 573235012614 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 573235012615 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573235012616 dimer interface [polypeptide binding]; other site 573235012617 conserved gate region; other site 573235012618 putative PBP binding loops; other site 573235012619 ABC-ATPase subunit interface; other site 573235012620 nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418 573235012621 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 573235012622 Walker A/P-loop; other site 573235012623 ATP binding site [chemical binding]; other site 573235012624 Q-loop/lid; other site 573235012625 ABC transporter signature motif; other site 573235012626 Walker B; other site 573235012627 D-loop; other site 573235012628 H-loop/switch region; other site 573235012629 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 573235012630 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 573235012631 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 573235012632 Walker A/P-loop; other site 573235012633 ATP binding site [chemical binding]; other site 573235012634 Q-loop/lid; other site 573235012635 ABC transporter signature motif; other site 573235012636 Walker B; other site 573235012637 D-loop; other site 573235012638 H-loop/switch region; other site 573235012639 nickel responsive regulator; Provisional; Region: PRK02967 573235012640 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 573235012641 PAAR motif; Region: PAAR_motif; cl15808 573235012642 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 573235012643 RHS Repeat; Region: RHS_repeat; pfam05593 573235012644 RHS Repeat; Region: RHS_repeat; pfam05593 573235012645 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 573235012646 RHS Repeat; Region: RHS_repeat; pfam05593 573235012647 RHS Repeat; Region: RHS_repeat; pfam05593 573235012648 RHS protein; Region: RHS; pfam03527 573235012649 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 573235012650 Domain of unknown function (DUF4329); Region: DUF4329; pfam14220 573235012651 RhsB, IS677, predicted H repeat-associated protein, N-terminal fragment 573235012652 RhsB, IS677, predicted H repeat-associated protein, C-terminal fragment 573235012653 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 573235012654 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 573235012655 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 573235012656 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 573235012657 Walker A/P-loop; other site 573235012658 ATP binding site [chemical binding]; other site 573235012659 Q-loop/lid; other site 573235012660 ABC transporter signature motif; other site 573235012661 Walker B; other site 573235012662 D-loop; other site 573235012663 H-loop/switch region; other site 573235012664 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 573235012665 Walker A/P-loop; other site 573235012666 ATP binding site [chemical binding]; other site 573235012667 Q-loop/lid; other site 573235012668 ABC transporter signature motif; other site 573235012669 Walker B; other site 573235012670 D-loop; other site 573235012671 H-loop/switch region; other site 573235012672 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 573235012673 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 573235012674 HlyD family secretion protein; Region: HlyD; pfam00529 573235012675 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 573235012676 HlyD family secretion protein; Region: HlyD_3; pfam13437 573235012677 Domain of unknown function (DUF4049); Region: DUF4049; pfam13258 573235012678 Domain of unknown function (DUF4049); Region: DUF4049; pfam13258 573235012679 Protein of unknown function (DUF2776); Region: DUF2776; pfam10951 573235012680 Predicted flavoproteins [General function prediction only]; Region: COG2081 573235012681 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 573235012682 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 573235012683 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 573235012684 universal stress protein UspB; Provisional; Region: PRK04960 573235012685 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 573235012686 Ligand Binding Site [chemical binding]; other site 573235012687 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 573235012688 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235012689 putative substrate translocation pore; other site 573235012690 POT family; Region: PTR2; pfam00854 573235012691 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573235012692 S-adenosylmethionine binding site [chemical binding]; other site 573235012693 oligopeptidase A; Provisional; Region: PRK10911 573235012694 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 573235012695 active site 573235012696 Zn binding site [ion binding]; other site 573235012697 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 573235012698 glutathione reductase; Validated; Region: PRK06116 573235012699 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 573235012700 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 573235012701 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 573235012702 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573235012703 dimerization interface [polypeptide binding]; other site 573235012704 putative DNA binding site [nucleotide binding]; other site 573235012705 putative Zn2+ binding site [ion binding]; other site 573235012706 arsenical pump membrane protein; Provisional; Region: PRK15445 573235012707 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 573235012708 transmembrane helices; other site 573235012709 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 573235012710 ArsC family; Region: ArsC; pfam03960 573235012711 catalytic residues [active] 573235012712 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573235012713 dimerization interface [polypeptide binding]; other site 573235012714 putative DNA binding site [nucleotide binding]; other site 573235012715 putative Zn2+ binding site [ion binding]; other site 573235012716 Predicted permeases [General function prediction only]; Region: COG0701 573235012717 conserved predicted protein, middle part 573235012718 conserved predicted protein, C-terminal fragment 573235012719 outer membrane lipoprotein, C-terminal part 573235012720 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 573235012721 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573235012722 DNA binding residues [nucleotide binding] 573235012723 dimerization interface [polypeptide binding]; other site 573235012724 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 573235012725 MgtC family; Region: MgtC; pfam02308 573235012726 acid-resistance protein; Provisional; Region: hdeB; PRK11566 573235012727 acid-resistance protein; Provisional; Region: PRK10208 573235012728 acid-resistance membrane protein; Provisional; Region: PRK10209 573235012729 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 573235012730 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 573235012731 pyruvate kinase; Provisional; Region: PRK05826 573235012732 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 573235012733 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 573235012734 HlyD family secretion protein; Region: HlyD_3; pfam13437 573235012735 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 573235012736 Protein export membrane protein; Region: SecD_SecF; cl14618 573235012737 transcriptional regulator YdeO; Provisional; Region: PRK09940 573235012738 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573235012739 DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978 573235012740 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573235012741 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 573235012742 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573235012743 catalytic residue [active] 573235012744 Haem-binding domain; Region: Haem_bd; pfam14376 573235012745 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 573235012746 trehalase; Provisional; Region: treF; PRK13270 573235012747 Trehalase; Region: Trehalase; pfam01204 573235012748 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 573235012749 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573235012750 DNA binding residues [nucleotide binding] 573235012751 dimerization interface [polypeptide binding]; other site 573235012752 Transcriptional regulator [Transcription]; Region: LysR; COG0583 573235012753 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573235012754 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 573235012755 putative effector binding pocket; other site 573235012756 putative dimerization interface [polypeptide binding]; other site 573235012757 inner membrane protein YhjD; Region: TIGR00766 573235012758 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235012759 metabolite-proton symporter; Region: 2A0106; TIGR00883 573235012760 putative substrate translocation pore; other site 573235012761 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 573235012762 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 573235012763 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 573235012764 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 573235012765 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 573235012766 substrate binding site [chemical binding]; other site 573235012767 ATP binding site [chemical binding]; other site 573235012768 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 573235012769 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 573235012770 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 573235012771 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 573235012772 putative diguanylate cyclase; Provisional; Region: PRK13561 573235012773 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573235012774 metal binding site [ion binding]; metal-binding site 573235012775 active site 573235012776 I-site; other site 573235012777 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 573235012778 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 573235012779 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573235012780 binding surface 573235012781 TPR motif; other site 573235012782 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573235012783 binding surface 573235012784 TPR motif; other site 573235012785 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 573235012786 endo-1,4-D-glucanase; Provisional; Region: PRK11097 573235012787 cellulose synthase regulator protein; Provisional; Region: PRK11114 573235012788 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 573235012789 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 573235012790 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 573235012791 DXD motif; other site 573235012792 PilZ domain; Region: PilZ; pfam07238 573235012793 cell division protein; Provisional; Region: PRK10037 573235012794 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 573235012795 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 573235012796 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 573235012797 celllulose biosynthesis operon protein BcsF/YhjT; Region: cellullose_BcsF; TIGR03493 573235012798 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 573235012799 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 573235012800 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 573235012801 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 573235012802 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 573235012803 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 573235012804 serine transporter; Region: stp; TIGR00814 573235012805 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 573235012806 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 573235012807 Walker A/P-loop; other site 573235012808 ATP binding site [chemical binding]; other site 573235012809 Q-loop/lid; other site 573235012810 ABC transporter signature motif; other site 573235012811 Walker B; other site 573235012812 D-loop; other site 573235012813 H-loop/switch region; other site 573235012814 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 573235012815 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 573235012816 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 573235012817 Walker A/P-loop; other site 573235012818 ATP binding site [chemical binding]; other site 573235012819 Q-loop/lid; other site 573235012820 ABC transporter signature motif; other site 573235012821 Walker B; other site 573235012822 D-loop; other site 573235012823 H-loop/switch region; other site 573235012824 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 573235012825 dipeptide transporter; Provisional; Region: PRK10913 573235012826 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 573235012827 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573235012828 dimer interface [polypeptide binding]; other site 573235012829 conserved gate region; other site 573235012830 putative PBP binding loops; other site 573235012831 ABC-ATPase subunit interface; other site 573235012832 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 573235012833 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573235012834 dimer interface [polypeptide binding]; other site 573235012835 conserved gate region; other site 573235012836 putative PBP binding loops; other site 573235012837 ABC-ATPase subunit interface; other site 573235012838 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 573235012839 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 573235012840 peptide binding site [polypeptide binding]; other site 573235012841 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 573235012842 Transposase; Region: DEDD_Tnp_IS110; pfam01548 573235012843 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 573235012844 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738 573235012845 EamA-like transporter family; Region: EamA; pfam00892 573235012846 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 573235012847 EamA-like transporter family; Region: EamA; pfam00892 573235012848 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 573235012849 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 573235012850 heme binding site [chemical binding]; other site 573235012851 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 573235012852 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 573235012853 FAD binding site [chemical binding]; other site 573235012854 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 573235012855 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 573235012856 putative catalytic residues [active] 573235012857 putative nucleotide binding site [chemical binding]; other site 573235012858 putative aspartate binding site [chemical binding]; other site 573235012859 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 573235012860 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 573235012861 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 573235012862 cystathionine gamma-synthase; Provisional; Region: PRK08045 573235012863 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 573235012864 homodimer interface [polypeptide binding]; other site 573235012865 substrate-cofactor binding pocket; other site 573235012866 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573235012867 catalytic residue [active] 573235012868 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 573235012869 dimerization interface [polypeptide binding]; other site 573235012870 DNA binding site [nucleotide binding] 573235012871 corepressor binding sites; other site 573235012872 hypothetical protein; Provisional; Region: PRK10030 573235012873 PAAR motif; Region: PAAR_motif; cl15808 573235012874 RHS Repeat; Region: RHS_repeat; pfam05593 573235012875 RHS Repeat; Region: RHS_repeat; pfam05593 573235012876 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 573235012877 RHS Repeat; Region: RHS_repeat; pfam05593 573235012878 RHS Repeat; Region: RHS_repeat; pfam05593 573235012879 RHS protein; Region: RHS; pfam03527 573235012880 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 573235012881 Domain of unknown function (DUF4329); Region: DUF4329; pfam14220 573235012882 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 573235012883 primosome assembly protein PriA; Validated; Region: PRK05580 573235012884 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573235012885 ATP binding site [chemical binding]; other site 573235012886 putative Mg++ binding site [ion binding]; other site 573235012887 helicase superfamily c-terminal domain; Region: HELICc; smart00490 573235012888 ATP-binding site [chemical binding]; other site 573235012889 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573235012890 DNA binding site [nucleotide binding] 573235012891 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 573235012892 domain linker motif; other site 573235012893 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 573235012894 dimerization interface [polypeptide binding]; other site 573235012895 ligand binding site [chemical binding]; other site 573235012896 essential cell division protein FtsN; Provisional; Region: PRK10927 573235012897 cell division protein FtsN; Provisional; Region: PRK12757 573235012898 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 573235012899 active site 573235012900 HslU subunit interaction site [polypeptide binding]; other site 573235012901 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 573235012902 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573235012903 Walker A motif; other site 573235012904 ATP binding site [chemical binding]; other site 573235012905 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 573235012906 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 573235012907 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 573235012908 UbiA prenyltransferase family; Region: UbiA; pfam01040 573235012909 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 573235012910 septal ring assembly protein ZapB; Provisional; Region: PRK15422 573235012911 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 573235012912 amphipathic channel; other site 573235012913 Asn-Pro-Ala signature motifs; other site 573235012914 glycerol kinase; Provisional; Region: glpK; PRK00047 573235012915 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 573235012916 N- and C-terminal domain interface [polypeptide binding]; other site 573235012917 active site 573235012918 MgATP binding site [chemical binding]; other site 573235012919 catalytic site [active] 573235012920 metal binding site [ion binding]; metal-binding site 573235012921 glycerol binding site [chemical binding]; other site 573235012922 homotetramer interface [polypeptide binding]; other site 573235012923 homodimer interface [polypeptide binding]; other site 573235012924 FBP binding site [chemical binding]; other site 573235012925 protein IIAGlc interface [polypeptide binding]; other site 573235012926 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 573235012927 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 573235012928 putative active site [active] 573235012929 ferredoxin-NADP reductase; Provisional; Region: PRK10926 573235012930 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 573235012931 FAD binding pocket [chemical binding]; other site 573235012932 FAD binding motif [chemical binding]; other site 573235012933 phosphate binding motif [ion binding]; other site 573235012934 beta-alpha-beta structure motif; other site 573235012935 NAD binding pocket [chemical binding]; other site 573235012936 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 573235012937 Ligand Binding Site [chemical binding]; other site 573235012938 hypothetical protein; Provisional; Region: PRK09981 573235012939 Predicted membrane protein [Function unknown]; Region: COG3152 573235012940 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 573235012941 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 573235012942 triosephosphate isomerase; Provisional; Region: PRK14567 573235012943 substrate binding site [chemical binding]; other site 573235012944 dimer interface [polypeptide binding]; other site 573235012945 catalytic triad [active] 573235012946 CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672 573235012947 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 573235012948 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 573235012949 substrate binding pocket [chemical binding]; other site 573235012950 membrane-bound complex binding site; other site 573235012951 hinge residues; other site 573235012952 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 573235012953 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 573235012954 active site 573235012955 ADP/pyrophosphate binding site [chemical binding]; other site 573235012956 dimerization interface [polypeptide binding]; other site 573235012957 allosteric effector site; other site 573235012958 fructose-1,6-bisphosphate binding site; other site 573235012959 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 573235012960 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 573235012961 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 573235012962 dimer interface [polypeptide binding]; other site 573235012963 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 573235012964 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573235012965 active site 573235012966 intermolecular recognition site; other site 573235012967 dimerization interface [polypeptide binding]; other site 573235012968 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573235012969 DNA binding site [nucleotide binding] 573235012970 two-component sensor protein; Provisional; Region: cpxA; PRK09470 573235012971 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573235012972 dimerization interface [polypeptide binding]; other site 573235012973 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573235012974 dimer interface [polypeptide binding]; other site 573235012975 phosphorylation site [posttranslational modification] 573235012976 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573235012977 ATP binding site [chemical binding]; other site 573235012978 Mg2+ binding site [ion binding]; other site 573235012979 G-X-G motif; other site 573235012980 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 573235012981 MOSC domain; Region: MOSC; pfam03473 573235012982 3-alpha domain; Region: 3-alpha; pfam03475 573235012983 2-keto-3-deoxygluconate transporter; Region: kdgT; TIGR00793 573235012984 superoxide dismutase; Provisional; Region: PRK10925 573235012985 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 573235012986 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 573235012987 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 573235012988 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 573235012989 transcriptional activator RhaR; Provisional; Region: PRK13500 573235012990 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 573235012991 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573235012992 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573235012993 DNA-binding transcriptional activator RhaS, L-rhamnose-binding, C-terminal fragment 573235012994 DNA-binding transcriptional activator RhaS, L-rhamnose-binding, N-terminal part 573235012995 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 573235012996 N- and C-terminal domain interface [polypeptide binding]; other site 573235012997 active site 573235012998 putative catalytic site [active] 573235012999 metal binding site [ion binding]; metal-binding site 573235013000 ATP binding site [chemical binding]; other site 573235013001 rhamnulokinase; Provisional; Region: rhaB; PRK10640 573235013002 carbohydrate binding site [chemical binding]; other site 573235013003 L-rhamnose isomerase; Provisional; Region: PRK01076 573235013004 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 573235013005 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 573235013006 intersubunit interface [polypeptide binding]; other site 573235013007 active site 573235013008 Zn2+ binding site [ion binding]; other site 573235013009 lactaldehyde reductase; Region: lactal_redase; TIGR02638 573235013010 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 573235013011 dimer interface [polypeptide binding]; other site 573235013012 active site 573235013013 metal binding site [ion binding]; metal-binding site 573235013014 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 573235013015 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 573235013016 active site 573235013017 phosphorylation site [posttranslational modification] 573235013018 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 573235013019 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 573235013020 active site 573235013021 P-loop; other site 573235013022 phosphorylation site [posttranslational modification] 573235013023 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 573235013024 putative peptidase; Provisional; Region: PRK09864 573235013025 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 573235013026 oligomer interface [polypeptide binding]; other site 573235013027 active site 573235013028 metal binding site [ion binding]; metal-binding site 573235013029 putative frv operon regulatory protein; Provisional; Region: PRK09863 573235013030 HTH domain; Region: HTH_11; pfam08279 573235013031 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 573235013032 active site 573235013033 phosphorylation site [posttranslational modification] 573235013034 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 573235013035 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 573235013036 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 573235013037 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 573235013038 [4Fe-4S] binding site [ion binding]; other site 573235013039 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 573235013040 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 573235013041 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 573235013042 molybdopterin cofactor binding site; other site 573235013043 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 573235013044 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 573235013045 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 573235013046 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 573235013047 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 573235013048 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 573235013049 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 573235013050 Transposase; Region: DEDD_Tnp_IS110; pfam01548 573235013051 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 573235013052 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 573235013053 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573235013054 non-specific DNA binding site [nucleotide binding]; other site 573235013055 salt bridge; other site 573235013056 sequence-specific DNA binding site [nucleotide binding]; other site 573235013057 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 573235013058 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 573235013059 substrate binding pocket [chemical binding]; other site 573235013060 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573235013061 Coenzyme A binding pocket [chemical binding]; other site 573235013062 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 573235013063 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 573235013064 putative active site [active] 573235013065 dimerization interface [polypeptide binding]; other site 573235013066 putative tRNAtyr binding site [nucleotide binding]; other site 573235013067 hypothetical protein; Reviewed; Region: PRK01637 573235013068 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 573235013069 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573235013070 motif II; other site 573235013071 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 573235013072 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573235013073 putative DNA binding site [nucleotide binding]; other site 573235013074 putative Zn2+ binding site [ion binding]; other site 573235013075 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 573235013076 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 573235013077 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 573235013078 substrate binding site [chemical binding]; other site 573235013079 ATP binding site [chemical binding]; other site 573235013080 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 573235013081 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 573235013082 Tagatose-1,6-bisphosphate aldolase [Carbohydrate transport and metabolism]; Region: LacD; COG3684 573235013083 catalytic residue [active] 573235013084 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 573235013085 dimerization interface [polypeptide binding]; other site 573235013086 putative active cleft [active] 573235013087 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 573235013088 active site 573235013089 catalytic residues [active] 573235013090 alpha-glucosidase; Provisional; Region: PRK10426 573235013091 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 573235013092 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 573235013093 putative active site [active] 573235013094 putative catalytic site [active] 573235013095 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 573235013096 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 573235013097 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 573235013098 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235013099 outer membrane porin L; Provisional; Region: ompL; PRK09980 573235013100 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235013101 putative substrate translocation pore; other site 573235013102 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 573235013103 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 573235013104 transcriptional regulator protein; Region: phnR; TIGR03337 573235013105 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573235013106 DNA-binding site [nucleotide binding]; DNA binding site 573235013107 UTRA domain; Region: UTRA; pfam07702 573235013108 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 573235013109 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 573235013110 G1 box; other site 573235013111 putative GEF interaction site [polypeptide binding]; other site 573235013112 GTP/Mg2+ binding site [chemical binding]; other site 573235013113 Switch I region; other site 573235013114 G2 box; other site 573235013115 G3 box; other site 573235013116 Switch II region; other site 573235013117 G4 box; other site 573235013118 G5 box; other site 573235013119 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 573235013120 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 573235013121 glutamine synthetase; Provisional; Region: glnA; PRK09469 573235013122 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 573235013123 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 573235013124 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 573235013125 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573235013126 putative active site [active] 573235013127 heme pocket [chemical binding]; other site 573235013128 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573235013129 dimer interface [polypeptide binding]; other site 573235013130 phosphorylation site [posttranslational modification] 573235013131 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573235013132 ATP binding site [chemical binding]; other site 573235013133 Mg2+ binding site [ion binding]; other site 573235013134 G-X-G motif; other site 573235013135 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 573235013136 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573235013137 active site 573235013138 phosphorylation site [posttranslational modification] 573235013139 intermolecular recognition site; other site 573235013140 dimerization interface [polypeptide binding]; other site 573235013141 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573235013142 Walker A motif; other site 573235013143 ATP binding site [chemical binding]; other site 573235013144 Walker B motif; other site 573235013145 arginine finger; other site 573235013146 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 573235013147 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 573235013148 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573235013149 FeS/SAM binding site; other site 573235013150 HemN C-terminal domain; Region: HemN_C; pfam06969 573235013151 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078 573235013152 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 573235013153 G1 box; other site 573235013154 GTP/Mg2+ binding site [chemical binding]; other site 573235013155 Switch I region; other site 573235013156 G2 box; other site 573235013157 G3 box; other site 573235013158 Switch II region; other site 573235013159 G4 box; other site 573235013160 G5 box; other site 573235013161 DNA polymerase I; Provisional; Region: PRK05755 573235013162 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 573235013163 active site 573235013164 metal binding site 1 [ion binding]; metal-binding site 573235013165 putative 5' ssDNA interaction site; other site 573235013166 metal binding site 3; metal-binding site 573235013167 metal binding site 2 [ion binding]; metal-binding site 573235013168 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 573235013169 putative DNA binding site [nucleotide binding]; other site 573235013170 putative metal binding site [ion binding]; other site 573235013171 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 573235013172 active site 573235013173 catalytic site [active] 573235013174 substrate binding site [chemical binding]; other site 573235013175 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 573235013176 active site 573235013177 DNA binding site [nucleotide binding] 573235013178 catalytic site [active] 573235013179 predicted endonuclease, N-terminal part 573235013180 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 573235013181 Transposase; Region: HTH_Tnp_1; pfam01527 573235013182 predicted transposase OrfB protein of insertion sequence IS600, C-terminal fragment 573235013183 predicted endonuclease, C-terminal part 573235013184 hypothetical protein; Provisional; Region: PRK11367 573235013185 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 573235013186 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 573235013187 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 573235013188 catalytic residues [active] 573235013189 hinge region; other site 573235013190 alpha helical domain; other site 573235013191 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 573235013192 serine/threonine protein kinase; Provisional; Region: PRK11768 573235013193 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 573235013194 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 573235013195 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 573235013196 GTP binding site; other site 573235013197 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 573235013198 Walker A motif; other site 573235013199 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 573235013200 potassium transporter; Provisional; Region: PRK10750 573235013201 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 573235013202 hypothetical protein; Provisional; Region: PRK11568 573235013203 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 573235013204 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 573235013205 proline dipeptidase; Provisional; Region: PRK13607 573235013206 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 573235013207 active site 573235013208 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 573235013209 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 573235013210 substrate binding site [chemical binding]; other site 573235013211 oxyanion hole (OAH) forming residues; other site 573235013212 trimer interface [polypeptide binding]; other site 573235013213 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 573235013214 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 573235013215 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 573235013216 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 573235013217 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 573235013218 dimer interface [polypeptide binding]; other site 573235013219 active site 573235013220 FMN reductase; Validated; Region: fre; PRK08051 573235013221 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 573235013222 FAD binding pocket [chemical binding]; other site 573235013223 FAD binding motif [chemical binding]; other site 573235013224 phosphate binding motif [ion binding]; other site 573235013225 beta-alpha-beta structure motif; other site 573235013226 NAD binding pocket [chemical binding]; other site 573235013227 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 573235013228 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 573235013229 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 573235013230 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 573235013231 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 573235013232 active site 573235013233 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 573235013234 sec-independent translocase; Provisional; Region: PRK01770 573235013235 sec-independent translocase; Provisional; Region: tatB; PRK00404 573235013236 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 573235013237 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 573235013238 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 573235013239 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 573235013240 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 573235013241 SCP-2 sterol transfer family; Region: SCP2; pfam02036 573235013242 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 573235013243 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573235013244 S-adenosylmethionine binding site [chemical binding]; other site 573235013245 DNA recombination protein RmuC; Provisional; Region: PRK10361 573235013246 RmuC family; Region: RmuC; pfam02646 573235013247 uridine phosphorylase; Provisional; Region: PRK11178 573235013248 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 573235013249 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 573235013250 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 573235013251 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 573235013252 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 573235013253 THF binding site; other site 573235013254 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 573235013255 substrate binding site [chemical binding]; other site 573235013256 THF binding site; other site 573235013257 zinc-binding site [ion binding]; other site 573235013258 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 573235013259 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573235013260 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 573235013261 putative dimerization interface [polypeptide binding]; other site 573235013262 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 573235013263 EamA-like transporter family; Region: EamA; pfam00892 573235013264 putative hydrolase; Provisional; Region: PRK10976 573235013265 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573235013266 active site 573235013267 motif I; other site 573235013268 motif II; other site 573235013269 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573235013270 lysophospholipase L2; Provisional; Region: PRK10749 573235013271 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 573235013272 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 573235013273 threonine efflux system; Provisional; Region: PRK10229 573235013274 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 573235013275 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573235013276 ATP binding site [chemical binding]; other site 573235013277 putative Mg++ binding site [ion binding]; other site 573235013278 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573235013279 nucleotide binding region [chemical binding]; other site 573235013280 ATP-binding site [chemical binding]; other site 573235013281 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 573235013282 Helicase and RNase D C-terminal; Region: HRDC; smart00341 573235013283 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 573235013284 dimerization interface [polypeptide binding]; other site 573235013285 substrate binding site [chemical binding]; other site 573235013286 active site 573235013287 calcium binding site [ion binding]; other site 573235013288 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 573235013289 CoenzymeA binding site [chemical binding]; other site 573235013290 subunit interaction site [polypeptide binding]; other site 573235013291 PHB binding site; other site 573235013292 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 573235013293 EamA-like transporter family; Region: EamA; cl17759 573235013294 predicted magnesium/nickel/cobalt transporter CorA, C-terminal part 573235013295 Protein of unknown function (DUF3289); Region: DUF3289; cl11840 573235013296 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 573235013297 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 573235013298 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 573235013299 Cl binding site [ion binding]; other site 573235013300 oligomer interface [polypeptide binding]; other site 573235013301 Predicted periplasmic protein [Function unknown]; Region: COG3698 573235013302 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 573235013303 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 573235013304 Part of AAA domain; Region: AAA_19; pfam13245 573235013305 Family description; Region: UvrD_C_2; pfam13538 573235013306 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 573235013307 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573235013308 motif II; other site 573235013309 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 573235013310 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 573235013311 active site 573235013312 DNA binding site [nucleotide binding] 573235013313 Int/Topo IB signature motif; other site 573235013314 hypothetical protein; Provisional; Region: PRK10963 573235013315 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 573235013316 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 573235013317 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 573235013318 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 573235013319 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 573235013320 DKNYY family; Region: DKNYY; pfam13644 573235013321 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 573235013322 putative iron binding site [ion binding]; other site 573235013323 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 573235013324 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 573235013325 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 573235013326 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 573235013327 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 573235013328 domain interfaces; other site 573235013329 active site 573235013330 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 573235013331 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 573235013332 active site 573235013333 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 573235013334 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 573235013335 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 573235013336 HemY protein N-terminus; Region: HemY_N; pfam07219 573235013337 acrylsulfatase-like enzyme AslA, N-terminal fragment 573235013338 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 573235013339 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573235013340 FeS/SAM binding site; other site 573235013341 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 573235013342 putative transport protein YifK; Provisional; Region: PRK10746 573235013343 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 573235013344 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 573235013345 putative common antigen polymerase; Provisional; Region: PRK02975 573235013346 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 573235013347 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 573235013348 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 573235013349 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 573235013350 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 573235013351 inhibitor-cofactor binding pocket; inhibition site 573235013352 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573235013353 catalytic residue [active] 573235013354 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 573235013355 Coenzyme A binding pocket [chemical binding]; other site 573235013356 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 573235013357 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 573235013358 substrate binding site; other site 573235013359 tetramer interface; other site 573235013360 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 573235013361 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 573235013362 NAD binding site [chemical binding]; other site 573235013363 substrate binding site [chemical binding]; other site 573235013364 homodimer interface [polypeptide binding]; other site 573235013365 active site 573235013366 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 573235013367 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 573235013368 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 573235013369 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 573235013370 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 573235013371 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 573235013372 active site 573235013373 homodimer interface [polypeptide binding]; other site 573235013374 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 573235013375 Chain length determinant protein; Region: Wzz; pfam02706 573235013376 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 573235013377 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 573235013378 Mg++ binding site [ion binding]; other site 573235013379 putative catalytic motif [active] 573235013380 substrate binding site [chemical binding]; other site 573235013381 transcription termination factor Rho; Provisional; Region: rho; PRK09376 573235013382 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 573235013383 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 573235013384 RNA binding site [nucleotide binding]; other site 573235013385 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 573235013386 multimer interface [polypeptide binding]; other site 573235013387 Walker A motif; other site 573235013388 ATP binding site [chemical binding]; other site 573235013389 Walker B motif; other site 573235013390 putative rho operon leader peptide; Provisional; Region: PRK09979 573235013391 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 573235013392 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 573235013393 catalytic residues [active] 573235013394 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 573235013395 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 573235013396 ATP binding site [chemical binding]; other site 573235013397 Mg++ binding site [ion binding]; other site 573235013398 motif III; other site 573235013399 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573235013400 nucleotide binding region [chemical binding]; other site 573235013401 ATP-binding site [chemical binding]; other site 573235013402 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 573235013403 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 573235013404 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 573235013405 Part of AAA domain; Region: AAA_19; pfam13245 573235013406 Family description; Region: UvrD_C_2; pfam13538 573235013407 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3692 573235013408 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 573235013409 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 573235013410 ketol-acid reductoisomerase; Validated; Region: PRK05225 573235013411 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 573235013412 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 573235013413 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 573235013414 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573235013415 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 573235013416 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 573235013417 putative dimerization interface [polypeptide binding]; other site 573235013418 threonine dehydratase; Reviewed; Region: PRK09224 573235013419 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 573235013420 tetramer interface [polypeptide binding]; other site 573235013421 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573235013422 catalytic residue [active] 573235013423 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 573235013424 putative Ile/Val binding site [chemical binding]; other site 573235013425 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 573235013426 putative Ile/Val binding site [chemical binding]; other site 573235013427 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 573235013428 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 573235013429 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 573235013430 homodimer interface [polypeptide binding]; other site 573235013431 substrate-cofactor binding pocket; other site 573235013432 catalytic residue [active] 573235013433 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 573235013434 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 573235013435 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 573235013436 PYR/PP interface [polypeptide binding]; other site 573235013437 dimer interface [polypeptide binding]; other site 573235013438 TPP binding site [chemical binding]; other site 573235013439 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 573235013440 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 573235013441 TPP-binding site [chemical binding]; other site 573235013442 dimer interface [polypeptide binding]; other site 573235013443 ilvG operon leader peptide; Provisional; Region: PRK10424 573235013444 putative ATP-dependent protease; Provisional; Region: PRK09862 573235013445 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 573235013446 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573235013447 Walker A motif; other site 573235013448 ATP binding site [chemical binding]; other site 573235013449 Walker B motif; other site 573235013450 arginine finger; other site 573235013451 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 573235013452 hypothetical protein; Provisional; Region: PRK11027 573235013453 transcriptional regulator HdfR; Provisional; Region: PRK03601 573235013454 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573235013455 LysR substrate binding domain; Region: LysR_substrate; pfam03466 573235013456 dimerization interface [polypeptide binding]; other site 573235013457 Transcriptional regulators [Transcription]; Region: FadR; COG2186 573235013458 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573235013459 DNA-binding site [nucleotide binding]; DNA binding site 573235013460 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 573235013461 putative transporter; Provisional; Region: PRK10504 573235013462 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235013463 putative substrate translocation pore; other site 573235013464 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235013465 transcriptional repressor RbsR; Provisional; Region: PRK10423 573235013466 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573235013467 DNA binding site [nucleotide binding] 573235013468 domain linker motif; other site 573235013469 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 573235013470 dimerization interface [polypeptide binding]; other site 573235013471 ligand binding site [chemical binding]; other site 573235013472 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 573235013473 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 573235013474 substrate binding site [chemical binding]; other site 573235013475 dimer interface [polypeptide binding]; other site 573235013476 ATP binding site [chemical binding]; other site 573235013477 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 573235013478 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 573235013479 ligand binding site [chemical binding]; other site 573235013480 dimerization interface [polypeptide binding]; other site 573235013481 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573235013482 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 573235013483 TM-ABC transporter signature motif; other site 573235013484 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 573235013485 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 573235013486 Walker A/P-loop; other site 573235013487 ATP binding site [chemical binding]; other site 573235013488 Q-loop/lid; other site 573235013489 ABC transporter signature motif; other site 573235013490 Walker B; other site 573235013491 D-loop; other site 573235013492 H-loop/switch region; other site 573235013493 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 573235013494 D-ribose pyranase; Provisional; Region: PRK11797 573235013495 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 573235013496 potassium uptake protein; Region: kup; TIGR00794 573235013497 regulatory ATPase RavA; Provisional; Region: PRK13531 573235013498 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573235013499 Walker A motif; other site 573235013500 ATP binding site [chemical binding]; other site 573235013501 Walker B motif; other site 573235013502 arginine finger; other site 573235013503 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 573235013504 hypothetical protein; Provisional; Region: yieM; PRK10997 573235013505 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 573235013506 metal ion-dependent adhesion site (MIDAS); other site 573235013507 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 573235013508 dimer interface [polypeptide binding]; other site 573235013509 active site 573235013510 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 573235013511 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573235013512 putative DNA binding site [nucleotide binding]; other site 573235013513 putative Zn2+ binding site [ion binding]; other site 573235013514 AsnC family; Region: AsnC_trans_reg; pfam01037 573235013515 FMN-binding protein MioC; Provisional; Region: PRK09004 573235013516 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 573235013517 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 573235013518 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 573235013519 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 573235013520 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573235013521 S-adenosylmethionine binding site [chemical binding]; other site 573235013522 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 573235013523 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 573235013524 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 573235013525 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 573235013526 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 573235013527 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 573235013528 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 573235013529 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 573235013530 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 573235013531 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 573235013532 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 573235013533 beta subunit interaction interface [polypeptide binding]; other site 573235013534 Walker A motif; other site 573235013535 ATP binding site [chemical binding]; other site 573235013536 Walker B motif; other site 573235013537 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 573235013538 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 573235013539 core domain interface [polypeptide binding]; other site 573235013540 delta subunit interface [polypeptide binding]; other site 573235013541 epsilon subunit interface [polypeptide binding]; other site 573235013542 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 573235013543 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 573235013544 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 573235013545 alpha subunit interaction interface [polypeptide binding]; other site 573235013546 Walker A motif; other site 573235013547 ATP binding site [chemical binding]; other site 573235013548 Walker B motif; other site 573235013549 inhibitor binding site; inhibition site 573235013550 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 573235013551 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 573235013552 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 573235013553 gamma subunit interface [polypeptide binding]; other site 573235013554 epsilon subunit interface [polypeptide binding]; other site 573235013555 LBP interface [polypeptide binding]; other site 573235013556 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 573235013557 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 573235013558 Substrate binding site; other site 573235013559 Mg++ binding site; other site 573235013560 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 573235013561 active site 573235013562 substrate binding site [chemical binding]; other site 573235013563 CoA binding site [chemical binding]; other site 573235013564 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 573235013565 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 573235013566 glutaminase active site [active] 573235013567 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 573235013568 dimer interface [polypeptide binding]; other site 573235013569 active site 573235013570 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 573235013571 dimer interface [polypeptide binding]; other site 573235013572 active site 573235013573 fimbrial protein; Provisional; Region: lpfA; PRK15289 573235013574 fimbrial chaperone protein; Provisional; Region: lfpB; PRK15290 573235013575 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 573235013576 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 573235013577 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 573235013578 PapC N-terminal domain; Region: PapC_N; pfam13954 573235013579 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 573235013580 PapC C-terminal domain; Region: PapC_C; pfam13953 573235013581 Fimbrial protein; Region: Fimbrial; cl01416 573235013582 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 573235013583 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 573235013584 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573235013585 dimer interface [polypeptide binding]; other site 573235013586 conserved gate region; other site 573235013587 putative PBP binding loops; other site 573235013588 ABC-ATPase subunit interface; other site 573235013589 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 573235013590 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573235013591 dimer interface [polypeptide binding]; other site 573235013592 conserved gate region; other site 573235013593 putative PBP binding loops; other site 573235013594 ABC-ATPase subunit interface; other site 573235013595 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 573235013596 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 573235013597 Walker A/P-loop; other site 573235013598 ATP binding site [chemical binding]; other site 573235013599 Q-loop/lid; other site 573235013600 ABC transporter signature motif; other site 573235013601 Walker B; other site 573235013602 D-loop; other site 573235013603 H-loop/switch region; other site 573235013604 transcriptional regulator PhoU; Provisional; Region: PRK11115 573235013605 PhoU domain; Region: PhoU; pfam01895 573235013606 PhoU domain; Region: PhoU; pfam01895 573235013607 transcriptional antiterminator BglG; Provisional; Region: PRK09772 573235013608 CAT RNA binding domain; Region: CAT_RBD; pfam03123 573235013609 PRD domain; Region: PRD; pfam00874 573235013610 PRD domain; Region: PRD; pfam00874 573235013611 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 573235013612 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 573235013613 active site turn [active] 573235013614 phosphorylation site [posttranslational modification] 573235013615 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 573235013616 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 573235013617 HPr interaction site; other site 573235013618 glycerol kinase (GK) interaction site [polypeptide binding]; other site 573235013619 active site 573235013620 phosphorylation site [posttranslational modification] 573235013621 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 573235013622 beta-galactosidase; Region: BGL; TIGR03356 573235013623 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 573235013624 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 573235013625 trimer interface; other site 573235013626 sugar binding site [chemical binding]; other site 573235013627 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 573235013628 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 573235013629 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 573235013630 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 573235013631 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 573235013632 active site 573235013633 trimer interface [polypeptide binding]; other site 573235013634 allosteric site; other site 573235013635 active site lid [active] 573235013636 Uncharacterized protein family (UPF0167); Region: UPF0167; cl01252 573235013637 putative inner membrane protein; Provisional; Region: PRK09823 573235013638 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 573235013639 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573235013640 active site 573235013641 motif I; other site 573235013642 motif II; other site 573235013643 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 573235013644 Predicted flavoprotein [General function prediction only]; Region: COG0431 573235013645 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 573235013646 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 573235013647 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 573235013648 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573235013649 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 573235013650 substrate binding pocket [chemical binding]; other site 573235013651 dimerization interface [polypeptide binding]; other site 573235013652 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 573235013653 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235013654 putative substrate translocation pore; other site 573235013655 tryptophan permease TnaB; Provisional; Region: PRK09664 573235013656 aromatic amino acid transport protein; Region: araaP; TIGR00837 573235013657 tryptophanase, leader peptide-associated; Region: tnaA_trp_ase; TIGR02617 573235013658 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 573235013659 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 573235013660 catalytic residue [active] 573235013661 Tryptophanese operon leader peptide; Region: Tna_leader; pfam08053 573235013662 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 573235013663 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 573235013664 trmE is a tRNA modification GTPase; Region: trmE; cd04164 573235013665 G1 box; other site 573235013666 GTP/Mg2+ binding site [chemical binding]; other site 573235013667 Switch I region; other site 573235013668 G2 box; other site 573235013669 Switch II region; other site 573235013670 G3 box; other site 573235013671 G4 box; other site 573235013672 G5 box; other site 573235013673 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 573235013674 membrane protein insertase; Provisional; Region: PRK01318 573235013675 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 573235013676 ribonuclease P; Reviewed; Region: rnpA; PRK01732 573235013677 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 573235013678 DnaA N-terminal domain; Region: DnaA_N; pfam11638 573235013679 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 573235013680 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573235013681 Walker A motif; other site 573235013682 ATP binding site [chemical binding]; other site 573235013683 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 573235013684 Walker B motif; other site 573235013685 arginine finger; other site 573235013686 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 573235013687 DnaA box-binding interface [nucleotide binding]; other site 573235013688 DNA polymerase III subunit beta; Validated; Region: PRK05643 573235013689 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 573235013690 putative DNA binding surface [nucleotide binding]; other site 573235013691 dimer interface [polypeptide binding]; other site 573235013692 beta-clamp/clamp loader binding surface; other site 573235013693 beta-clamp/translesion DNA polymerase binding surface; other site 573235013694 recF protein; Region: recf; TIGR00611 573235013695 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573235013696 Walker A/P-loop; other site 573235013697 ATP binding site [chemical binding]; other site 573235013698 Q-loop/lid; other site 573235013699 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573235013700 ABC transporter signature motif; other site 573235013701 Walker B; other site 573235013702 D-loop; other site 573235013703 H-loop/switch region; other site 573235013704 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 573235013705 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573235013706 Mg2+ binding site [ion binding]; other site 573235013707 G-X-G motif; other site 573235013708 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 573235013709 anchoring element; other site 573235013710 dimer interface [polypeptide binding]; other site 573235013711 ATP binding site [chemical binding]; other site 573235013712 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 573235013713 active site 573235013714 putative metal-binding site [ion binding]; other site 573235013715 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 573235013716 hypothetical protein; Provisional; Region: PRK11426 573235013717 sugar phosphate phosphatase; Provisional; Region: PRK10513 573235013718 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573235013719 active site 573235013720 motif I; other site 573235013721 motif II; other site 573235013722 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573235013723 hypothetical protein; Provisional; Region: PRK10215 573235013724 Transcriptional regulators [Transcription]; Region: FadR; COG2186 573235013725 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573235013726 DNA-binding site [nucleotide binding]; DNA binding site 573235013727 FCD domain; Region: FCD; pfam07729 573235013728 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 573235013729 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 573235013730 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 573235013731 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 573235013732 active site 573235013733 intersubunit interface [polypeptide binding]; other site 573235013734 catalytic residue [active] 573235013735 DgoA protein, C-terminal part 573235013736 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235013737 D-galactonate transporter; Region: 2A0114; TIGR00893 573235013738 putative substrate translocation pore; other site 573235013739 putative oxidoreductase; Provisional; Region: PRK11445 573235013740 hypothetical protein; Provisional; Region: PRK07236 573235013741 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 573235013742 hypothetical protein; Provisional; Region: PRK11616 573235013743 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 573235013744 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 573235013745 putative dimer interface [polypeptide binding]; other site 573235013746 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 573235013747 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 573235013748 putative dimer interface [polypeptide binding]; other site 573235013749 putative transporter; Validated; Region: PRK03818 573235013750 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 573235013751 TrkA-C domain; Region: TrkA_C; pfam02080 573235013752 TrkA-C domain; Region: TrkA_C; pfam02080 573235013753 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 573235013754 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 573235013755 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573235013756 DNA-binding site [nucleotide binding]; DNA binding site 573235013757 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 573235013758 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 573235013759 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 573235013760 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 573235013761 active site turn [active] 573235013762 phosphorylation site [posttranslational modification] 573235013763 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 573235013764 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 573235013765 NAD(P) binding site [chemical binding]; other site 573235013766 LDH/MDH dimer interface [polypeptide binding]; other site 573235013767 substrate binding site [chemical binding]; other site 573235013768 predicted 6-phospho-beta-glucosidase, C-terminal part 573235013769 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 573235013770 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573235013771 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 573235013772 putative transporter; Provisional; Region: PRK10484 573235013773 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 573235013774 Na binding site [ion binding]; other site 573235013775 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 573235013776 Sulfatase; Region: Sulfatase; pfam00884 573235013777 Predicted membrane protein [Function unknown]; Region: COG2149 573235013778 Domain of unknown function (DUF202); Region: DUF202; pfam02656 573235013779 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 573235013780 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 573235013781 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235013782 putative substrate translocation pore; other site 573235013783 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 573235013784 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 573235013785 PYR/PP interface [polypeptide binding]; other site 573235013786 dimer interface [polypeptide binding]; other site 573235013787 TPP binding site [chemical binding]; other site 573235013788 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 573235013789 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 573235013790 TPP-binding site [chemical binding]; other site 573235013791 dimer interface [polypeptide binding]; other site 573235013792 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 573235013793 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 573235013794 putative valine binding site [chemical binding]; other site 573235013795 dimer interface [polypeptide binding]; other site 573235013796 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 573235013797 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573235013798 active site 573235013799 phosphorylation site [posttranslational modification] 573235013800 intermolecular recognition site; other site 573235013801 dimerization interface [polypeptide binding]; other site 573235013802 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573235013803 DNA binding residues [nucleotide binding] 573235013804 dimerization interface [polypeptide binding]; other site 573235013805 sensory histidine kinase UhpB; Provisional; Region: PRK11644 573235013806 MASE1; Region: MASE1; pfam05231 573235013807 Histidine kinase; Region: HisKA_3; pfam07730 573235013808 regulatory protein UhpC; Provisional; Region: PRK11663 573235013809 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235013810 putative substrate translocation pore; other site 573235013811 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 573235013812 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235013813 putative substrate translocation pore; other site 573235013814 cryptic adenine deaminase; Provisional; Region: PRK10027 573235013815 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 573235013816 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 573235013817 active site 573235013818 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 573235013819 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 573235013820 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 573235013821 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 573235013822 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235013823 putative substrate translocation pore; other site 573235013824 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 573235013825 lipoprotein, YaeC family; Region: TIGR00363 573235013826 EamA-like transporter family; Region: EamA; pfam00892 573235013827 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 573235013828 EamA-like transporter family; Region: EamA; pfam00892 573235013829 sugar efflux transporter; Region: 2A0120; TIGR00899 573235013830 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235013831 putative substrate translocation pore; other site 573235013832 Prophage ECO26_P20, P4-like phage 573235013833 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 573235013834 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 573235013835 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 573235013836 active site 573235013837 metal binding site [ion binding]; metal-binding site 573235013838 interdomain interaction site; other site 573235013839 D5 N terminal like; Region: D5_N; smart00885 573235013840 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 573235013841 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 573235013842 Transposase; Region: HTH_Tnp_1; pfam01527 573235013843 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 573235013844 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573235013845 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 573235013846 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 573235013847 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 573235013848 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573235013849 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 573235013850 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 573235013851 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 573235013852 Ash protein family; Region: Phage_ASH; pfam10554 573235013853 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 573235013854 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 573235013855 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 573235013856 Phage polarity suppression protein (Psu); Region: Psu; pfam07455 573235013857 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573235013858 ATP binding site [chemical binding]; other site 573235013859 putative Mg++ binding site [ion binding]; other site 573235013860 nucleotide binding region [chemical binding]; other site 573235013861 helicase superfamily c-terminal domain; Region: HELICc; smart00490 573235013862 ATP-binding site [chemical binding]; other site 573235013863 integrase; Provisional; Region: PRK09692 573235013864 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 573235013865 active site 573235013866 Int/Topo IB signature motif; other site 573235013867 putative transporter; Provisional; Region: PRK11462 573235013868 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 573235013869 putative alpha-glucosidase; Provisional; Region: PRK10658 573235013870 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 573235013871 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 573235013872 active site 573235013873 homotrimer interface [polypeptide binding]; other site 573235013874 catalytic site [active] 573235013875 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 573235013876 AsmA family; Region: AsmA; pfam05170 573235013877 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 573235013878 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 573235013879 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 573235013880 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 573235013881 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 573235013882 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 573235013883 generic binding surface II; other site 573235013884 ssDNA binding site; other site 573235013885 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573235013886 ATP binding site [chemical binding]; other site 573235013887 putative Mg++ binding site [ion binding]; other site 573235013888 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573235013889 nucleotide binding region [chemical binding]; other site 573235013890 ATP-binding site [chemical binding]; other site 573235013891 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 573235013892 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 573235013893 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 573235013894 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 573235013895 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573235013896 Zn2+ binding site [ion binding]; other site 573235013897 Mg2+ binding site [ion binding]; other site 573235013898 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 573235013899 synthetase active site [active] 573235013900 NTP binding site [chemical binding]; other site 573235013901 metal binding site [ion binding]; metal-binding site 573235013902 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 573235013903 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 573235013904 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 573235013905 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 573235013906 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 573235013907 catalytic site [active] 573235013908 G-X2-G-X-G-K; other site 573235013909 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 573235013910 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 573235013911 nucleotide binding pocket [chemical binding]; other site 573235013912 K-X-D-G motif; other site 573235013913 catalytic site [active] 573235013914 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 573235013915 Predicted membrane protein [Function unknown]; Region: COG2860 573235013916 UPF0126 domain; Region: UPF0126; pfam03458 573235013917 UPF0126 domain; Region: UPF0126; pfam03458 573235013918 DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525 573235013919 BRO family, N-terminal domain; Region: Bro-N; pfam02498 573235013920 hypothetical protein; Provisional; Region: PRK11820 573235013921 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 573235013922 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 573235013923 ribonuclease PH; Reviewed; Region: rph; PRK00173 573235013924 Ribonuclease PH; Region: RNase_PH_bact; cd11362 573235013925 hexamer interface [polypeptide binding]; other site 573235013926 active site 573235013927 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 573235013928 active site 573235013929 division inhibitor protein; Provisional; Region: slmA; PRK09480 573235013930 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573235013931 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 573235013932 trimer interface [polypeptide binding]; other site 573235013933 active site 573235013934 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 573235013935 Flavoprotein; Region: Flavoprotein; pfam02441 573235013936 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 573235013937 hypothetical protein; Reviewed; Region: PRK00024 573235013938 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 573235013939 MPN+ (JAMM) motif; other site 573235013940 Zinc-binding site [ion binding]; other site 573235013941 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 573235013942 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 573235013943 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 573235013944 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 573235013945 DNA binding site [nucleotide binding] 573235013946 catalytic residue [active] 573235013947 H2TH interface [polypeptide binding]; other site 573235013948 putative catalytic residues [active] 573235013949 turnover-facilitating residue; other site 573235013950 intercalation triad [nucleotide binding]; other site 573235013951 8OG recognition residue [nucleotide binding]; other site 573235013952 putative reading head residues; other site 573235013953 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 573235013954 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 573235013955 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 573235013956 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 573235013957 active site 573235013958 (T/H)XGH motif; other site 573235013959 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 573235013960 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 573235013961 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 573235013962 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 573235013963 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 573235013964 putative active site [active] 573235013965 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 573235013966 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573235013967 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 573235013968 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 573235013969 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 573235013970 Ligand binding site; other site 573235013971 metal-binding site 573235013972 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 573235013973 Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; cl17526 573235013974 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 573235013975 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 573235013976 Ligand binding site; other site 573235013977 metal-binding site 573235013978 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 573235013979 lipopolysaccharide 1,2-N-acetylglucosaminetransferase; Provisional; Region: PRK15484 573235013980 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 573235013981 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 573235013982 O-antigen ligase RfaL; Provisional; Region: PRK15487 573235013983 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 573235013984 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 573235013985 putative active site [active] 573235013986 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 573235013987 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 573235013988 putative active site [active] 573235013989 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 573235013990 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 573235013991 NADP binding site [chemical binding]; other site 573235013992 homopentamer interface [polypeptide binding]; other site 573235013993 substrate binding site [chemical binding]; other site 573235013994 active site 573235013995 hypothetical protein; Provisional; Region: PRK11346 573235013996 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 573235013997 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 573235013998 substrate-cofactor binding pocket; other site 573235013999 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573235014000 catalytic residue [active] 573235014001 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 573235014002 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 573235014003 NAD(P) binding site [chemical binding]; other site 573235014004 putative glycosyl transferase; Provisional; Region: PRK10073 573235014005 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 573235014006 active site 573235014007 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 573235014008 NodB motif; other site 573235014009 putative active site [active] 573235014010 putative catalytic site [active] 573235014011 Zn binding site [ion binding]; other site 573235014012 AmiB activator; Provisional; Region: PRK11637 573235014013 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 573235014014 Peptidase family M23; Region: Peptidase_M23; pfam01551 573235014015 phosphoglyceromutase; Provisional; Region: PRK05434 573235014016 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 573235014017 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 573235014018 active site residue [active] 573235014019 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 573235014020 GSH binding site [chemical binding]; other site 573235014021 catalytic residues [active] 573235014022 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 573235014023 SecA binding site; other site 573235014024 Preprotein binding site; other site 573235014025 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 573235014026 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 573235014027 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 573235014028 serine acetyltransferase; Provisional; Region: cysE; PRK11132 573235014029 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 573235014030 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 573235014031 trimer interface [polypeptide binding]; other site 573235014032 active site 573235014033 substrate binding site [chemical binding]; other site 573235014034 CoA binding site [chemical binding]; other site 573235014035 putative rRNA methylase; Provisional; Region: PRK10358 573235014036 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 573235014037 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 573235014038 phosphate binding site [ion binding]; other site 573235014039 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 573235014040 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573235014041 DNA-binding site [nucleotide binding]; DNA binding site 573235014042 FCD domain; Region: FCD; pfam07729 573235014043 L-lactate permease; Provisional; Region: PRK10420 573235014044 glycolate transporter; Provisional; Region: PRK09695 573235014045 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 573235014046 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 573235014047 trimer interface [polypeptide binding]; other site 573235014048 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 573235014049 trimer interface [polypeptide binding]; other site 573235014050 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 573235014051 Haemagglutinin; Region: HIM; pfam05662 573235014052 Haemagglutinin; Region: HIM; pfam05662 573235014053 YadA-like C-terminal region; Region: YadA; pfam03895 573235014054 Protein of unknown function (DUF3251); Region: DUF3251; cl08186 573235014055 hypothetical protein; Provisional; Region: PRK11020 573235014056 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 573235014057 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 573235014058 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 573235014059 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 573235014060 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 573235014061 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 573235014062 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 573235014063 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 573235014064 active site 573235014065 P-loop; other site 573235014066 phosphorylation site [posttranslational modification] 573235014067 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 573235014068 active site 573235014069 phosphorylation site [posttranslational modification] 573235014070 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 573235014071 conserved predicted protein, C-terminal deleted 573235014072 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 573235014073 RhsA core protein with extension, C-terminal fragment 573235014074 putative lyase; Provisional; Region: PRK09687 573235014075 PAAR motif; Region: PAAR_motif; cl15808 573235014076 RHS Repeat; Region: RHS_repeat; cl11982 573235014077 RHS Repeat; Region: RHS_repeat; pfam05593 573235014078 RHS Repeat; Region: RHS_repeat; cl11982 573235014079 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 573235014080 RHS Repeat; Region: RHS_repeat; pfam05593 573235014081 RHS Repeat; Region: RHS_repeat; pfam05593 573235014082 RHS protein; Region: RHS; pfam03527 573235014083 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 573235014084 putative glutathione S-transferase; Provisional; Region: PRK10357 573235014085 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 573235014086 putative C-terminal domain interface [polypeptide binding]; other site 573235014087 putative GSH binding site (G-site) [chemical binding]; other site 573235014088 putative dimer interface [polypeptide binding]; other site 573235014089 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 573235014090 dimer interface [polypeptide binding]; other site 573235014091 N-terminal domain interface [polypeptide binding]; other site 573235014092 putative substrate binding pocket (H-site) [chemical binding]; other site 573235014093 selenocysteine synthase; Provisional; Region: PRK04311 573235014094 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 573235014095 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 573235014096 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 573235014097 catalytic residue [active] 573235014098 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 573235014099 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 573235014100 G1 box; other site 573235014101 putative GEF interaction site [polypeptide binding]; other site 573235014102 GTP/Mg2+ binding site [chemical binding]; other site 573235014103 Switch I region; other site 573235014104 G2 box; other site 573235014105 G3 box; other site 573235014106 Switch II region; other site 573235014107 G4 box; other site 573235014108 G5 box; other site 573235014109 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 573235014110 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 573235014111 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 573235014112 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 573235014113 putative alcohol dehydrogenase; Provisional; Region: PRK09860 573235014114 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 573235014115 dimer interface [polypeptide binding]; other site 573235014116 active site 573235014117 metal binding site [ion binding]; metal-binding site 573235014118 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 573235014119 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 573235014120 NAD(P) binding site [chemical binding]; other site 573235014121 catalytic residues [active] 573235014122 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 573235014123 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 573235014124 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 573235014125 HlyD family secretion protein; Region: HlyD_3; pfam13437 573235014126 Transcriptional regulator [Transcription]; Region: LysR; COG0583 573235014127 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573235014128 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 573235014129 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 573235014130 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 573235014131 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 573235014132 intersubunit interface [polypeptide binding]; other site 573235014133 active site 573235014134 Zn2+ binding site [ion binding]; other site 573235014135 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 573235014136 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 573235014137 AP (apurinic/apyrimidinic) site pocket; other site 573235014138 DNA interaction; other site 573235014139 Metal-binding active site; metal-binding site 573235014140 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 573235014141 active site 573235014142 dimer interface [polypeptide binding]; other site 573235014143 magnesium binding site [ion binding]; other site 573235014144 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 573235014145 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 573235014146 putative N- and C-terminal domain interface [polypeptide binding]; other site 573235014147 putative active site [active] 573235014148 MgATP binding site [chemical binding]; other site 573235014149 catalytic site [active] 573235014150 metal binding site [ion binding]; metal-binding site 573235014151 putative xylulose binding site [chemical binding]; other site 573235014152 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 573235014153 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 573235014154 L-dehydroascorbate transporter large permease subunit; Provisional; Region: PRK15060 573235014155 DctM-like transporters; Region: DctM; pfam06808 573235014156 2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM; Provisional; Region: PRK09877 573235014157 uncharacterized protein, YhcH/YjgK/YiaL family; Region: TIGR00022 573235014158 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 573235014159 Transcriptional regulator [Transcription]; Region: IclR; COG1414 573235014160 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 573235014161 Bacterial transcriptional regulator; Region: IclR; pfam01614 573235014162 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 573235014163 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 573235014164 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 573235014165 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573235014166 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573235014167 homodimer interface [polypeptide binding]; other site 573235014168 catalytic residue [active] 573235014169 alpha-amylase; Reviewed; Region: malS; PRK09505 573235014170 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 573235014171 active site 573235014172 catalytic site [active] 573235014173 hypothetical protein; Provisional; Region: PRK10356 573235014174 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 573235014175 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 573235014176 putative dimerization interface [polypeptide binding]; other site 573235014177 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573235014178 putative ligand binding site [chemical binding]; other site 573235014179 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573235014180 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 573235014181 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573235014182 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573235014183 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 573235014184 TM-ABC transporter signature motif; other site 573235014185 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 573235014186 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 573235014187 Walker A/P-loop; other site 573235014188 ATP binding site [chemical binding]; other site 573235014189 Q-loop/lid; other site 573235014190 ABC transporter signature motif; other site 573235014191 Walker B; other site 573235014192 D-loop; other site 573235014193 H-loop/switch region; other site 573235014194 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 573235014195 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 573235014196 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 573235014197 putative ligand binding site [chemical binding]; other site 573235014198 xylose isomerase; Provisional; Region: PRK05474 573235014199 xylose isomerase; Region: xylose_isom_A; TIGR02630 573235014200 xylulokinase; Provisional; Region: PRK15027 573235014201 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 573235014202 N- and C-terminal domain interface [polypeptide binding]; other site 573235014203 active site 573235014204 MgATP binding site [chemical binding]; other site 573235014205 catalytic site [active] 573235014206 metal binding site [ion binding]; metal-binding site 573235014207 xylulose binding site [chemical binding]; other site 573235014208 homodimer interface [polypeptide binding]; other site 573235014209 hypothetical protein; Provisional; Region: PRK11403 573235014210 yiaA/B two helix domain; Region: YiaAB; pfam05360 573235014211 hypothetical protein; Provisional; Region: PRK11383 573235014212 yiaA/B two helix domain; Region: YiaAB; pfam05360 573235014213 yiaA/B two helix domain; Region: YiaAB; pfam05360 573235014214 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 573235014215 Acyltransferase family; Region: Acyl_transf_3; pfam01757 573235014216 YsaB-like lipoprotein; Region: YsaB; pfam13983 573235014217 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 573235014218 dimer interface [polypeptide binding]; other site 573235014219 motif 1; other site 573235014220 active site 573235014221 motif 2; other site 573235014222 motif 3; other site 573235014223 glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211 573235014224 DALR anticodon binding domain; Region: DALR_1; pfam05746 573235014225 anticodon binding site; other site 573235014226 tRNA binding surface [nucleotide binding]; other site 573235014227 small toxic polypeptide; Provisional; Region: PRK09759 573235014228 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 573235014229 DNA-binding site [nucleotide binding]; DNA binding site 573235014230 RNA-binding motif; other site 573235014231 Predicted transcriptional regulator [Transcription]; Region: COG2944 573235014232 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573235014233 non-specific DNA binding site [nucleotide binding]; other site 573235014234 salt bridge; other site 573235014235 sequence-specific DNA binding site [nucleotide binding]; other site 573235014236 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 573235014237 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 573235014238 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 573235014239 dimerization interface [polypeptide binding]; other site 573235014240 ligand binding site [chemical binding]; other site 573235014241 NADP binding site [chemical binding]; other site 573235014242 catalytic site [active] 573235014243 putative outer membrane lipoprotein; Provisional; Region: PRK10510 573235014244 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 573235014245 ligand binding site [chemical binding]; other site 573235014246 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 573235014247 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 573235014248 molybdopterin cofactor binding site [chemical binding]; other site 573235014249 substrate binding site [chemical binding]; other site 573235014250 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 573235014251 molybdopterin cofactor binding site; other site 573235014252 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 573235014253 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573235014254 Coenzyme A binding pocket [chemical binding]; other site 573235014255 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 573235014256 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 573235014257 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 573235014258 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235014259 putative substrate translocation pore; other site 573235014260 long polar fimbrial protein LpfA; Provisional; Region: PRK15209 573235014261 long polar fimbrial chaperone LpfB; Provisional; Region: PRK15208 573235014262 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 573235014263 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 573235014264 long polar fimbrial outer membrane usher protein LpfC; Provisional; Region: PRK15207 573235014265 PapC N-terminal domain; Region: PapC_N; pfam13954 573235014266 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 573235014267 PapC C-terminal domain; Region: PapC_C; pfam13953 573235014268 long polar fimbrial protein LpfD; Provisional; Region: PRK15206 573235014269 long polar fimbrial protein LpfE; Provisional; Region: PRK15205 573235014270 phosphoethanolamine transferase; Provisional; Region: PRK11560 573235014271 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 573235014272 Sulfatase; Region: Sulfatase; pfam00884 573235014273 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 573235014274 Transposase; Region: DEDD_Tnp_IS110; pfam01548 573235014275 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 573235014276 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 573235014277 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 573235014278 dimer interface [polypeptide binding]; other site 573235014279 active site 573235014280 metal binding site [ion binding]; metal-binding site 573235014281 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 573235014282 active site 573235014283 intersubunit interactions; other site 573235014284 catalytic residue [active] 573235014285 fused predicted PTS enzymes PtsA: Hpr component/enzyme I component/enzyme IIA component, C-terminal part 573235014286 fused predicted PTS enzymes PtsA: Hpr component/enzyme I component/enzyme IIA component, N-terminal part 573235014287 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 573235014288 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 573235014289 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 573235014290 active site 573235014291 P-loop; other site 573235014292 phosphorylation site [posttranslational modification] 573235014293 putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983 573235014294 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 573235014295 dimer interface [polypeptide binding]; other site 573235014296 active site 573235014297 glycine loop; other site 573235014298 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573235014299 FeS/SAM binding site; other site 573235014300 pyruvate formate lyase II activase; Provisional; Region: PRK10076 573235014301 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 573235014302 active site 573235014303 P-loop; other site 573235014304 phosphorylation site [posttranslational modification] 573235014305 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 573235014306 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573235014307 hypothetical protein; Provisional; Region: PRK10649 573235014308 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 573235014309 Sulfatase; Region: Sulfatase; pfam00884 573235014310 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 573235014311 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 573235014312 acetylornithine deacetylase; Provisional; Region: PRK05111 573235014313 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 573235014314 metal binding site [ion binding]; metal-binding site 573235014315 putative dimer interface [polypeptide binding]; other site 573235014316 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 573235014317 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 573235014318 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 573235014319 nucleotide binding site [chemical binding]; other site 573235014320 N-acetyl-L-glutamate binding site [chemical binding]; other site 573235014321 argininosuccinate lyase; Provisional; Region: PRK04833 573235014322 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 573235014323 active sites [active] 573235014324 tetramer interface [polypeptide binding]; other site 573235014325 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 573235014326 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573235014327 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 573235014328 dimerization interface [polypeptide binding]; other site 573235014329 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 573235014330 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 573235014331 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 573235014332 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 573235014333 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573235014334 hypothetical protein; Provisional; Region: PRK11056 573235014335 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 573235014336 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573235014337 S-adenosylmethionine binding site [chemical binding]; other site 573235014338 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 573235014339 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 573235014340 N-terminal plug; other site 573235014341 ligand-binding site [chemical binding]; other site 573235014342 glutamate racemase; Provisional; Region: PRK00865 573235014343 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 573235014344 FAD binding domain; Region: FAD_binding_4; pfam01565 573235014345 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 573235014346 Biotin operon repressor [Transcription]; Region: BirA; COG1654 573235014347 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 573235014348 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 573235014349 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 573235014350 pantothenate kinase; Provisional; Region: PRK05439 573235014351 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 573235014352 ATP-binding site [chemical binding]; other site 573235014353 CoA-binding site [chemical binding]; other site 573235014354 Mg2+-binding site [ion binding]; other site 573235014355 elongation factor Tu; Reviewed; Region: PRK00049 573235014356 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 573235014357 G1 box; other site 573235014358 GEF interaction site [polypeptide binding]; other site 573235014359 GTP/Mg2+ binding site [chemical binding]; other site 573235014360 Switch I region; other site 573235014361 G2 box; other site 573235014362 G3 box; other site 573235014363 Switch II region; other site 573235014364 G4 box; other site 573235014365 G5 box; other site 573235014366 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 573235014367 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 573235014368 Antibiotic Binding Site [chemical binding]; other site 573235014369 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 573235014370 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 573235014371 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 573235014372 putative homodimer interface [polypeptide binding]; other site 573235014373 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 573235014374 heterodimer interface [polypeptide binding]; other site 573235014375 homodimer interface [polypeptide binding]; other site 573235014376 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 573235014377 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 573235014378 23S rRNA interface [nucleotide binding]; other site 573235014379 L7/L12 interface [polypeptide binding]; other site 573235014380 putative thiostrepton binding site; other site 573235014381 L25 interface [polypeptide binding]; other site 573235014382 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 573235014383 mRNA/rRNA interface [nucleotide binding]; other site 573235014384 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 573235014385 23S rRNA interface [nucleotide binding]; other site 573235014386 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 573235014387 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 573235014388 core dimer interface [polypeptide binding]; other site 573235014389 peripheral dimer interface [polypeptide binding]; other site 573235014390 L10 interface [polypeptide binding]; other site 573235014391 L11 interface [polypeptide binding]; other site 573235014392 putative EF-Tu interaction site [polypeptide binding]; other site 573235014393 putative EF-G interaction site [polypeptide binding]; other site 573235014394 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 573235014395 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 573235014396 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 573235014397 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 573235014398 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 573235014399 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 573235014400 RPB3 interaction site [polypeptide binding]; other site 573235014401 RPB1 interaction site [polypeptide binding]; other site 573235014402 RPB11 interaction site [polypeptide binding]; other site 573235014403 RPB10 interaction site [polypeptide binding]; other site 573235014404 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 573235014405 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 573235014406 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 573235014407 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 573235014408 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 573235014409 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 573235014410 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 573235014411 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 573235014412 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 573235014413 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 573235014414 DNA binding site [nucleotide binding] 573235014415 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 573235014416 stationary phase growth adaptation protein; Provisional; Region: PRK09717 573235014417 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 573235014418 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573235014419 FeS/SAM binding site; other site 573235014420 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 573235014421 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 573235014422 ThiS interaction site; other site 573235014423 putative active site [active] 573235014424 tetramer interface [polypeptide binding]; other site 573235014425 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 573235014426 thiS-thiF/thiG interaction site; other site 573235014427 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 573235014428 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 573235014429 ATP binding site [chemical binding]; other site 573235014430 substrate interface [chemical binding]; other site 573235014431 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 573235014432 thiamine phosphate binding site [chemical binding]; other site 573235014433 active site 573235014434 pyrophosphate binding site [ion binding]; other site 573235014435 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 573235014436 ThiC-associated domain; Region: ThiC-associated; pfam13667 573235014437 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 573235014438 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 573235014439 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 573235014440 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 573235014441 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 573235014442 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 573235014443 putative NADH binding site [chemical binding]; other site 573235014444 putative active site [active] 573235014445 nudix motif; other site 573235014446 putative metal binding site [ion binding]; other site 573235014447 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 573235014448 substrate binding site [chemical binding]; other site 573235014449 active site 573235014450 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 573235014451 Active_site [active] 573235014452 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 573235014453 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 573235014454 IHF dimer interface [polypeptide binding]; other site 573235014455 IHF - DNA interface [nucleotide binding]; other site 573235014456 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 573235014457 zinc resistance protein; Provisional; Region: zraP; PRK11546 573235014458 dimer interface [polypeptide binding]; other site 573235014459 sensor protein ZraS; Provisional; Region: PRK10364 573235014460 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573235014461 dimer interface [polypeptide binding]; other site 573235014462 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573235014463 ATP binding site [chemical binding]; other site 573235014464 Mg2+ binding site [ion binding]; other site 573235014465 G-X-G motif; other site 573235014466 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 573235014467 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573235014468 active site 573235014469 phosphorylation site [posttranslational modification] 573235014470 intermolecular recognition site; other site 573235014471 dimerization interface [polypeptide binding]; other site 573235014472 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573235014473 Walker A motif; other site 573235014474 ATP binding site [chemical binding]; other site 573235014475 Walker B motif; other site 573235014476 arginine finger; other site 573235014477 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 573235014478 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 573235014479 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 573235014480 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 573235014481 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 573235014482 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 573235014483 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 573235014484 purine monophosphate binding site [chemical binding]; other site 573235014485 dimer interface [polypeptide binding]; other site 573235014486 putative catalytic residues [active] 573235014487 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 573235014488 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 573235014489 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573235014490 Coenzyme A binding pocket [chemical binding]; other site 573235014491 homoserine O-succinyltransferase; Provisional; Region: PRK05368 573235014492 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 573235014493 proposed active site lysine [active] 573235014494 conserved cys residue [active] 573235014495 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 573235014496 malate synthase A; Region: malate_syn_A; TIGR01344 573235014497 active site 573235014498 isocitrate lyase; Provisional; Region: PRK15063 573235014499 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 573235014500 tetramer interface [polypeptide binding]; other site 573235014501 active site 573235014502 Mg2+/Mn2+ binding site [ion binding]; other site 573235014503 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 573235014504 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 573235014505 T3SS effector EspL, N-terminal part 573235014506 transcriptional repressor IclR; Provisional; Region: PRK11569 573235014507 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 573235014508 Bacterial transcriptional regulator; Region: IclR; pfam01614 573235014509 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 573235014510 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 573235014511 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 573235014512 substrate binding pocket [chemical binding]; other site 573235014513 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 573235014514 B12 binding site [chemical binding]; other site 573235014515 cobalt ligand [ion binding]; other site 573235014516 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 573235014517 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 573235014518 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 573235014519 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 573235014520 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 573235014521 active site pocket [active] 573235014522 oxyanion hole [active] 573235014523 catalytic triad [active] 573235014524 active site nucleophile [active] 573235014525 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 573235014526 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 573235014527 putative NAD(P) binding site [chemical binding]; other site 573235014528 catalytic Zn binding site [ion binding]; other site 573235014529 PTS system, sorbose-permease IID component, C-terminal part 573235014530 PTS system, sorbose-permease IID component, N-terminal part 573235014531 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 573235014532 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 573235014533 active site 573235014534 phosphorylation site [posttranslational modification] 573235014535 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 573235014536 active pocket/dimerization site; other site 573235014537 active site 573235014538 phosphorylation site [posttranslational modification] 573235014539 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 573235014540 classical (c) SDRs; Region: SDR_c; cd05233 573235014541 NAD(P) binding site [chemical binding]; other site 573235014542 active site 573235014543 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 573235014544 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573235014545 putative DNA binding site [nucleotide binding]; other site 573235014546 putative Zn2+ binding site [ion binding]; other site 573235014547 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 573235014548 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 573235014549 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 573235014550 RNA binding surface [nucleotide binding]; other site 573235014551 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 573235014552 probable active site [active] 573235014553 hypothetical protein; Provisional; Region: PRK10515 573235014554 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 573235014555 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 573235014556 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 573235014557 Zeta toxin; Region: Zeta_toxin; pfam06414 573235014558 aspartate kinase III; Validated; Region: PRK09084 573235014559 AAK_AKiii-LysC-EC: Amino Acid Kinase Superfamily (AAK), AKiii-LysC-EC: this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKIII. AKIII is a monofunctional class enzyme (LysC) found in some...; Region: AAK_AKiii-LysC-EC; cd04258 573235014560 nucleotide binding site [chemical binding]; other site 573235014561 putative catalytic residues [active] 573235014562 aspartate binding site [chemical binding]; other site 573235014563 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 573235014564 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 573235014565 dimer interface [polypeptide binding]; other site 573235014566 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 573235014567 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 573235014568 active site 573235014569 dimer interface [polypeptide binding]; other site 573235014570 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 573235014571 dimer interface [polypeptide binding]; other site 573235014572 active site 573235014573 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 573235014574 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 573235014575 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 573235014576 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 573235014577 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 573235014578 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235014579 putative substrate translocation pore; other site 573235014580 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235014581 part of maltose permease MalG, inner membrane; membrane component of ABC superfamily 573235014582 part of maltose permease MalF, periplasmic; membrane component of ABC superfamily 573235014583 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 573235014584 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 573235014585 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 573235014586 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 573235014587 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 573235014588 Walker A/P-loop; other site 573235014589 ATP binding site [chemical binding]; other site 573235014590 Q-loop/lid; other site 573235014591 ABC transporter signature motif; other site 573235014592 Walker B; other site 573235014593 D-loop; other site 573235014594 H-loop/switch region; other site 573235014595 TOBE domain; Region: TOBE_2; pfam08402 573235014596 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 573235014597 trimer interface; other site 573235014598 sugar binding site [chemical binding]; other site 573235014599 maltose regulon periplasmic protein; Provisional; Region: PRK10564 573235014600 T3SS effector EspX, N-terminal part 573235014601 T3SS effector EspX, C-terminal part 573235014602 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 573235014603 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 573235014604 UbiA prenyltransferase family; Region: UbiA; pfam01040 573235014605 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 573235014606 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 573235014607 putative acyl-acceptor binding pocket; other site 573235014608 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 573235014609 LexA repressor; Validated; Region: PRK00215 573235014610 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 573235014611 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 573235014612 Catalytic site [active] 573235014613 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 573235014614 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 573235014615 hypothetical protein; Provisional; Region: PRK10428 573235014616 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 573235014617 metal binding site 2 [ion binding]; metal-binding site 573235014618 putative DNA binding helix; other site 573235014619 metal binding site 1 [ion binding]; metal-binding site 573235014620 dimer interface [polypeptide binding]; other site 573235014621 structural Zn2+ binding site [ion binding]; other site 573235014622 Protein of unknown function (DUF2713); Region: DUF2713; pfam10897 573235014623 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 573235014624 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 573235014625 FMN binding site [chemical binding]; other site 573235014626 active site 573235014627 catalytic residues [active] 573235014628 substrate binding site [chemical binding]; other site 573235014629 phage shock protein G; Reviewed; Region: pspG; PRK09459 573235014630 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 573235014631 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 573235014632 NADP binding site [chemical binding]; other site 573235014633 dimer interface [polypeptide binding]; other site 573235014634 replicative DNA helicase; Provisional; Region: PRK08006 573235014635 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 573235014636 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 573235014637 Walker A motif; other site 573235014638 ATP binding site [chemical binding]; other site 573235014639 Walker B motif; other site 573235014640 DNA binding loops [nucleotide binding] 573235014641 alanine racemase; Reviewed; Region: alr; PRK00053 573235014642 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 573235014643 active site 573235014644 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 573235014645 substrate binding site [chemical binding]; other site 573235014646 catalytic residues [active] 573235014647 dimer interface [polypeptide binding]; other site 573235014648 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 573235014649 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573235014650 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573235014651 homodimer interface [polypeptide binding]; other site 573235014652 catalytic residue [active] 573235014653 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573235014654 active site 573235014655 motif I; other site 573235014656 motif II; other site 573235014657 secondary thiamine-phosphate synthase enzyme; Region: TIGR00149_YjbQ 573235014658 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 573235014659 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 573235014660 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 573235014661 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 573235014662 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 573235014663 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 573235014664 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 573235014665 dimer interface [polypeptide binding]; other site 573235014666 ssDNA binding site [nucleotide binding]; other site 573235014667 tetramer (dimer of dimers) interface [polypeptide binding]; other site 573235014668 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 573235014669 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 573235014670 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 573235014671 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 573235014672 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 573235014673 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573235014674 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 573235014675 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 573235014676 DNA binding residues [nucleotide binding] 573235014677 dimer interface [polypeptide binding]; other site 573235014678 [2Fe-2S] cluster binding site [ion binding]; other site 573235014679 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 573235014680 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 573235014681 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 573235014682 T3SS effector EspX, C-terminal part 573235014683 T3SS effector EspX, N-terminal part 573235014684 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 573235014685 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 573235014686 Na binding site [ion binding]; other site 573235014687 Predicted membrane protein [Function unknown]; Region: COG3162 573235014688 acetyl-CoA synthetase; Provisional; Region: PRK00174 573235014689 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 573235014690 active site 573235014691 CoA binding site [chemical binding]; other site 573235014692 acyl-activating enzyme (AAE) consensus motif; other site 573235014693 AMP binding site [chemical binding]; other site 573235014694 acetate binding site [chemical binding]; other site 573235014695 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 573235014696 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 573235014697 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 573235014698 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 573235014699 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 573235014700 heme lyase subunit NrfE; Provisional; Region: PRK10369 573235014701 formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144 573235014702 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 573235014703 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573235014704 binding surface 573235014705 TPR motif; other site 573235014706 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 573235014707 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 573235014708 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 573235014709 Sel1-like repeats; Region: SEL1; smart00671 573235014710 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 573235014711 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 573235014712 [4Fe-4S] binding site [ion binding]; other site 573235014713 molybdopterin cofactor binding site; other site 573235014714 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 573235014715 molybdopterin cofactor binding site; other site 573235014716 putative outer membrane efflux protein MdtP; Provisional; Region: PRK09915 573235014717 multidrug efflux system protein MdtO; Provisional; Region: PRK11427 573235014718 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 573235014719 multidrug resistance protein MdtN; Provisional; Region: PRK10476 573235014720 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 573235014721 HlyD family secretion protein; Region: HlyD_3; pfam13437 573235014722 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 573235014723 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 573235014724 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 573235014725 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 573235014726 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573235014727 Coenzyme A binding pocket [chemical binding]; other site 573235014728 ribose 1,5-bisphosphokinase; Provisional; Region: PRK10078 573235014729 AAA domain; Region: AAA_18; pfam13238 573235014730 active site 573235014731 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 573235014732 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 573235014733 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 573235014734 active site 573235014735 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 573235014736 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 573235014737 Walker A/P-loop; other site 573235014738 ATP binding site [chemical binding]; other site 573235014739 Q-loop/lid; other site 573235014740 ABC transporter signature motif; other site 573235014741 Walker B; other site 573235014742 D-loop; other site 573235014743 H-loop/switch region; other site 573235014744 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 573235014745 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 573235014746 Walker A/P-loop; other site 573235014747 ATP binding site [chemical binding]; other site 573235014748 Q-loop/lid; other site 573235014749 ABC transporter signature motif; other site 573235014750 Walker B; other site 573235014751 D-loop; other site 573235014752 H-loop/switch region; other site 573235014753 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 573235014754 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 573235014755 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnI; COG3626 573235014756 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnH; COG3625 573235014757 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 573235014758 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 573235014759 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573235014760 DNA-binding site [nucleotide binding]; DNA binding site 573235014761 UTRA domain; Region: UTRA; pfam07702 573235014762 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 573235014763 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573235014764 dimer interface [polypeptide binding]; other site 573235014765 conserved gate region; other site 573235014766 putative PBP binding loops; other site 573235014767 ABC-ATPase subunit interface; other site 573235014768 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 573235014769 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 573235014770 substrate binding pocket [chemical binding]; other site 573235014771 membrane-bound complex binding site; other site 573235014772 hinge residues; other site 573235014773 phosphonate/organophosphate ester transporter subunit; Provisional; Region: PRK09984 573235014774 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 573235014775 Walker A/P-loop; other site 573235014776 ATP binding site [chemical binding]; other site 573235014777 Q-loop/lid; other site 573235014778 ABC transporter signature motif; other site 573235014779 Walker B; other site 573235014780 D-loop; other site 573235014781 H-loop/switch region; other site 573235014782 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 573235014783 dimer interface [polypeptide binding]; other site 573235014784 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 573235014785 hypothetical protein; Provisional; Region: PRK10220 573235014786 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 573235014787 PhnA protein; Region: PhnA; pfam03831 573235014788 hypothetical protein; Provisional; Region: PRK09866 573235014789 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 573235014790 G1 box; other site 573235014791 GTP/Mg2+ binding site [chemical binding]; other site 573235014792 G2 box; other site 573235014793 Switch I region; other site 573235014794 G3 box; other site 573235014795 Switch II region; other site 573235014796 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 573235014797 G2 box; other site 573235014798 Switch I region; other site 573235014799 G3 box; other site 573235014800 Switch II region; other site 573235014801 G4 box; other site 573235014802 G5 box; other site 573235014803 YjcZ-like protein; Region: YjcZ; pfam13990 573235014804 proline/glycine betaine transporter; Provisional; Region: PRK10642 573235014805 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235014806 putative substrate translocation pore; other site 573235014807 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 573235014808 sensor protein BasS/PmrB; Provisional; Region: PRK10755 573235014809 HAMP domain; Region: HAMP; pfam00672 573235014810 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573235014811 dimer interface [polypeptide binding]; other site 573235014812 phosphorylation site [posttranslational modification] 573235014813 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573235014814 ATP binding site [chemical binding]; other site 573235014815 Mg2+ binding site [ion binding]; other site 573235014816 G-X-G motif; other site 573235014817 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 573235014818 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573235014819 active site 573235014820 phosphorylation site [posttranslational modification] 573235014821 intermolecular recognition site; other site 573235014822 dimerization interface [polypeptide binding]; other site 573235014823 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573235014824 DNA binding site [nucleotide binding] 573235014825 putative metal dependent hydrolase; Provisional; Region: PRK11598 573235014826 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 573235014827 Sulfatase; Region: Sulfatase; pfam00884 573235014828 arginine:agmatin antiporter; Provisional; Region: PRK10644 573235014829 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 573235014830 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573235014831 arginine decarboxylase; Provisional; Region: PRK15029 573235014832 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 573235014833 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 573235014834 homodimer interface [polypeptide binding]; other site 573235014835 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573235014836 catalytic residue [active] 573235014837 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 573235014838 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 573235014839 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573235014840 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573235014841 alpha-galactosidase; Provisional; Region: PRK15076 573235014842 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 573235014843 NAD binding site [chemical binding]; other site 573235014844 sugar binding site [chemical binding]; other site 573235014845 divalent metal binding site [ion binding]; other site 573235014846 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 573235014847 dimer interface [polypeptide binding]; other site 573235014848 melibiose:sodium symporter; Provisional; Region: PRK10429 573235014849 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 573235014850 hypothetical protein; Provisional; Region: PRK09867 573235014851 fumarate hydratase; Provisional; Region: PRK15389 573235014852 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 573235014853 Fumarase C-terminus; Region: Fumerase_C; pfam05683 573235014854 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 573235014855 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 573235014856 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 573235014857 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573235014858 active site 573235014859 phosphorylation site [posttranslational modification] 573235014860 intermolecular recognition site; other site 573235014861 dimerization interface [polypeptide binding]; other site 573235014862 Transcriptional regulator; Region: CitT; pfam12431 573235014863 sensory histidine kinase DcuS; Provisional; Region: PRK11086 573235014864 PAS domain; Region: PAS; smart00091 573235014865 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573235014866 ATP binding site [chemical binding]; other site 573235014867 Mg2+ binding site [ion binding]; other site 573235014868 G-X-G motif; other site 573235014869 Uncharacterized conserved protein [Function unknown]; Region: COG3592 573235014870 Predicted acetyltransferase [General function prediction only]; Region: COG2388 573235014871 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 573235014872 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 573235014873 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 573235014874 dimer interface [polypeptide binding]; other site 573235014875 putative anticodon binding site; other site 573235014876 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 573235014877 motif 1; other site 573235014878 active site 573235014879 motif 2; other site 573235014880 motif 3; other site 573235014881 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 573235014882 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235014883 putative substrate translocation pore; other site 573235014884 POT family; Region: PTR2; pfam00854 573235014885 lysine decarboxylase CadA; Provisional; Region: PRK15400 573235014886 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 573235014887 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 573235014888 homodimer interface [polypeptide binding]; other site 573235014889 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573235014890 catalytic residue [active] 573235014891 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 573235014892 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 573235014893 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 573235014894 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573235014895 DNA binding site [nucleotide binding] 573235014896 Integrative element ECO26_IE08, LEE 573235014897 Integrative element ECO26_IE08; predicted transposase OrfB of insertion sequence IS2, N-terminal fragment 573235014898 IS2 repressor TnpA; Reviewed; Region: PRK09413 573235014899 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 573235014900 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204 573235014901 SdiA-regulated; Region: SdiA-regulated; cd09971 573235014902 putative active site [active] 573235014903 EspG protein; Region: EspG; pfam06872 573235014904 DNA-binding protein H-NS [General function prediction only]; Region: Hns; COG2916 573235014905 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 573235014906 type III secretion system protein, YseE family; Region: type_III_yscE; TIGR02501 573235014907 Type III secretion system filament chaperone CesA; Region: CesA; pfam11439 573235014908 Type III secretion system subunit; Region: T3SS_LEE_assoc; pfam13327 573235014909 Type III secretory pathway, component EscR [Intracellular trafficking and secretion]; Region: EscR; COG4790 573235014910 Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794 573235014911 Type III secretory pathway, component EscT [Intracellular trafficking and secretion]; Region: EscT; COG4791 573235014912 secretion system apparatus protein SsaU; Reviewed; Region: PRK12721 573235014913 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 573235014914 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 573235014915 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 573235014916 N-acetyl-D-glucosamine binding site [chemical binding]; other site 573235014917 catalytic residue [active] 573235014918 negative regulator GrlR; Provisional; Region: PRK14051 573235014919 Protein of unknown function (DUF1401); Region: DUF1401; pfam07180 573235014920 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 573235014921 Tetratricopeptide repeat; Region: TPR_3; pfam07720 573235014922 outer membrane secretin SsaC; Provisional; Region: PRK15346 573235014923 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 573235014924 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 573235014925 Type III secretory pathway, lipoprotein EscJ [Intracellular trafficking and secretion]; Region: EscJ; COG4669 573235014926 SepZ; Region: SepZ; pfam06066 573235014927 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 573235014928 FHIPEP family; Region: FHIPEP; pfam00771 573235014929 type III secretion apparatus H+-transporting two-sector ATPase; Region: III_secr_ATP; TIGR02546 573235014930 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 573235014931 Walker A motif; other site 573235014932 ATP binding site [chemical binding]; other site 573235014933 Walker B motif; other site 573235014934 Protein of unknown function (DUF1106); Region: DUF1106; pfam06523 573235014935 SepQ protein; Region: SepQ; pfam06622 573235014936 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 573235014937 IpaB/EvcA family; Region: IpaB_EvcA; pfam03278 573235014938 Translocated intimin receptor (Tir) N-terminus; Region: Tir_receptor_N; pfam07490 573235014939 Translocated intimin receptor (Tir) intimin-binding domain; Region: Tir_receptor_M; pfam03549 573235014940 Translocated intimin receptor (Tir) C-terminus; Region: Tir_receptor_C; pfam07489 573235014941 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 573235014942 LysM domain; Region: LysM; pfam01476 573235014943 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 573235014944 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 573235014945 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 573235014946 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 573235014947 Intimin C-type lectin domain; Region: Intimin_C; pfam07979 573235014948 type III secretion system protein SsaD; Provisional; Region: PRK15367 573235014949 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 573235014950 HrpJ-like domain; Region: HrpJ; cl15454 573235014951 type III secretion effector delivery regulator, TyeA family; Region: type_III_tyeA; TIGR02511 573235014952 EspA-like secreted protein; Region: EspA; pfam03433 573235014953 Uncharacterized conserved protein [Function unknown]; Region: COG5613 573235014954 Enterobacterial EspB protein; Region: EspB; pfam05802 573235014955 pathogenicity island 2 effector protein SseE; Provisional; Region: PRK15360 573235014956 type III secretion apparatus needle protein; Region: III_needle; TIGR02105 573235014957 type III secretion system protein, SsaH family; Region: type_III_ssaH; TIGR02498 573235014958 Integrative element ECO26_IE08; transposase of insertion sequence IS604,N-terminal fragment 573235014959 TcdB toxin N-terminal helical domain; Region: TcdB_N; pfam12918 573235014960 TcdA/TcdB catalytic glycosyltransferase domain; Region: TcdA_TcdB; pfam12919 573235014961 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 573235014962 cysteine protease domain, YopT-type; Region: yopT_cys_prot; TIGR01586 573235014963 Protein of unknown function (DUF3491); Region: DUF3491; pfam11996 573235014964 Integrative element ECO26_IE08; predicted transposase of insertion sequence IS630, partial 573235014965 non-LEE encoded effector protein NleB; Provisional; Region: PRK15382 573235014966 type III secretion system protein; Provisional; Region: PRK15384; cl14665 573235014967 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 573235014968 Integrative element ECO26_IE08; predicted transposase of insertion sequence IS608, central part 573235014969 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 573235014970 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 573235014971 Transposase; Region: DDE_Tnp_ISL3; pfam01610 573235014972 Transposase; Region: DDE_Tnp_ISL3; pfam01610 573235014973 Integrative element ECO26_IE08; predicted protein Orf3 in insertion sequence ISEc8, N-terminal disrupted 573235014974 integrase; Provisional; Region: PRK09692 573235014975 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 573235014976 active site 573235014977 Int/Topo IB signature motif; other site 573235014978 putative transcriptional regulator; Provisional; Region: PRK11640 573235014979 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573235014980 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 573235014981 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 573235014982 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 573235014983 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 573235014984 DsbD alpha interface [polypeptide binding]; other site 573235014985 catalytic residues [active] 573235014986 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 573235014987 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 573235014988 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 573235014989 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 573235014990 Aspartase; Region: Aspartase; cd01357 573235014991 active sites [active] 573235014992 tetramer interface [polypeptide binding]; other site 573235014993 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 573235014994 putative transporter; Provisional; Region: PRK11021 573235014995 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 573235014996 oligomerisation interface [polypeptide binding]; other site 573235014997 mobile loop; other site 573235014998 roof hairpin; other site 573235014999 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 573235015000 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 573235015001 ring oligomerisation interface [polypeptide binding]; other site 573235015002 ATP/Mg binding site [chemical binding]; other site 573235015003 stacking interactions; other site 573235015004 hinge regions; other site 573235015005 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 573235015006 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 573235015007 Transposase; Region: DEDD_Tnp_IS110; pfam01548 573235015008 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 573235015009 excinuclease ABC subunit B; Provisional; Region: PRK05298 573235015010 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 573235015011 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573235015012 FeS/SAM binding site; other site 573235015013 elongation factor P; Validated; Region: PRK00529 573235015014 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 573235015015 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 573235015016 RNA binding site [nucleotide binding]; other site 573235015017 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 573235015018 RNA binding site [nucleotide binding]; other site 573235015019 entericidin A; Provisional; Region: PRK09810 573235015020 entericidin B membrane lipoprotein; Provisional; Region: PRK10081 573235015021 multidrug efflux system protein; Provisional; Region: PRK11431 573235015022 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 573235015023 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 573235015024 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 573235015025 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 573235015026 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 573235015027 Iron-sulfur protein interface; other site 573235015028 proximal quinone binding site [chemical binding]; other site 573235015029 C-subunit interface; other site 573235015030 distal quinone binding site; other site 573235015031 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 573235015032 D-subunit interface [polypeptide binding]; other site 573235015033 Iron-sulfur protein interface; other site 573235015034 proximal quinone binding site [chemical binding]; other site 573235015035 distal quinone binding site [chemical binding]; other site 573235015036 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 573235015037 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 573235015038 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 573235015039 L-aspartate oxidase; Provisional; Region: PRK06175 573235015040 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 573235015041 poxB regulator PoxA; Provisional; Region: PRK09350 573235015042 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 573235015043 motif 1; other site 573235015044 dimer interface [polypeptide binding]; other site 573235015045 active site 573235015046 motif 2; other site 573235015047 motif 3; other site 573235015048 inner membrane transporter YjeM; Provisional; Region: PRK15238 573235015049 Protein of unknown function (DUF2645); Region: DUF2645; pfam10840 573235015050 putative mechanosensitive channel protein; Provisional; Region: PRK10929 573235015051 linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated...; Region: H15; cl00073 573235015052 DNA-binding site [nucleotide binding]; DNA binding site 573235015053 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 573235015054 Mechanosensitive ion channel; Region: MS_channel; pfam00924 573235015055 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 573235015056 GTPase RsgA; Reviewed; Region: PRK12288 573235015057 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 573235015058 RNA binding site [nucleotide binding]; other site 573235015059 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 573235015060 GTPase/Zn-binding domain interface [polypeptide binding]; other site 573235015061 GTP/Mg2+ binding site [chemical binding]; other site 573235015062 G4 box; other site 573235015063 G5 box; other site 573235015064 G1 box; other site 573235015065 Switch I region; other site 573235015066 G2 box; other site 573235015067 G3 box; other site 573235015068 Switch II region; other site 573235015069 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 573235015070 catalytic site [active] 573235015071 putative active site [active] 573235015072 putative substrate binding site [chemical binding]; other site 573235015073 dimer interface [polypeptide binding]; other site 573235015074 epoxyqueuosine reductase; Region: TIGR00276 573235015075 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 573235015076 putative carbohydrate kinase; Provisional; Region: PRK10565 573235015077 yjeF N-terminal region; Region: yjeF_nterm; TIGR00197 573235015078 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 573235015079 putative substrate binding site [chemical binding]; other site 573235015080 putative ATP binding site [chemical binding]; other site 573235015081 ADP-binding protein; Provisional; Region: PRK10646 573235015082 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 573235015083 AMIN domain; Region: AMIN; pfam11741 573235015084 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 573235015085 active site 573235015086 metal binding site [ion binding]; metal-binding site 573235015087 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 573235015088 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573235015089 ATP binding site [chemical binding]; other site 573235015090 Mg2+ binding site [ion binding]; other site 573235015091 G-X-G motif; other site 573235015092 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 573235015093 ATP binding site [chemical binding]; other site 573235015094 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 573235015095 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 573235015096 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 573235015097 bacterial Hfq-like; Region: Hfq; cd01716 573235015098 hexamer interface [polypeptide binding]; other site 573235015099 Sm1 motif; other site 573235015100 RNA binding site [nucleotide binding]; other site 573235015101 Sm2 motif; other site 573235015102 GTPase HflX; Provisional; Region: PRK11058 573235015103 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 573235015104 HflX GTPase family; Region: HflX; cd01878 573235015105 G1 box; other site 573235015106 GTP/Mg2+ binding site [chemical binding]; other site 573235015107 Switch I region; other site 573235015108 G2 box; other site 573235015109 G3 box; other site 573235015110 Switch II region; other site 573235015111 G4 box; other site 573235015112 G5 box; other site 573235015113 FtsH protease regulator HflK; Provisional; Region: PRK10930 573235015114 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 573235015115 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 573235015116 FtsH protease regulator HflC; Provisional; Region: PRK11029 573235015117 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 573235015118 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 573235015119 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 573235015120 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 573235015121 GDP-binding site [chemical binding]; other site 573235015122 ACT binding site; other site 573235015123 IMP binding site; other site 573235015124 Predicted transcriptional regulator [Transcription]; Region: COG1959 573235015125 transcriptional repressor NsrR; Provisional; Region: PRK11014 573235015126 exoribonuclease R; Provisional; Region: PRK11642 573235015127 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 573235015128 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 573235015129 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 573235015130 RNB domain; Region: RNB; pfam00773 573235015131 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 573235015132 RNA binding site [nucleotide binding]; other site 573235015133 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 573235015134 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 573235015135 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 573235015136 Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; cl01551 573235015137 PspA/IM30 family; Region: PspA_IM30; pfam04012 573235015138 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 573235015139 Predicted membrane protein [Function unknown]; Region: COG3766 573235015140 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 573235015141 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 573235015142 Predicted integral membrane protein [Function unknown]; Region: COG5463 573235015143 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 573235015144 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 573235015145 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 573235015146 FAD binding site [chemical binding]; other site 573235015147 substrate binding site [chemical binding]; other site 573235015148 catalytic residues [active] 573235015149 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 573235015150 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 573235015151 esterase; Provisional; Region: PRK10566 573235015152 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 573235015153 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 573235015154 transcriptional repressor UlaR; Provisional; Region: PRK13509 573235015155 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 573235015156 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 573235015157 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 573235015158 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 573235015159 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 573235015160 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 573235015161 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 573235015162 active site 573235015163 P-loop; other site 573235015164 phosphorylation site [posttranslational modification] 573235015165 L-ascorbate-specific enzyme IIA component UlaC of PTS, N-terminal part 573235015166 L-ascorbate-specific enzyme IIA component UlaC of PTS, C-terminal part 573235015167 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 573235015168 active site 573235015169 dimer interface [polypeptide binding]; other site 573235015170 magnesium binding site [ion binding]; other site 573235015171 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 573235015172 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 573235015173 AP (apurinic/apyrimidinic) site pocket; other site 573235015174 DNA interaction; other site 573235015175 Metal-binding active site; metal-binding site 573235015176 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 573235015177 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 573235015178 intersubunit interface [polypeptide binding]; other site 573235015179 active site 573235015180 Zn2+ binding site [ion binding]; other site 573235015181 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 573235015182 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 573235015183 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 573235015184 dimer interface [polypeptide binding]; other site 573235015185 ssDNA binding site [nucleotide binding]; other site 573235015186 tetramer (dimer of dimers) interface [polypeptide binding]; other site 573235015187 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 573235015188 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 573235015189 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 573235015190 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 573235015191 Protein of unknown function (DUF2686); Region: DUF2686; pfam10887 573235015192 Transposase IS200 like; Region: Y1_Tnp; pfam01797 573235015193 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 573235015194 Probable transposase; Region: OrfB_IS605; pfam01385 573235015195 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 573235015196 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 573235015197 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 573235015198 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 573235015199 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 573235015200 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 573235015201 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 573235015202 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 573235015203 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 573235015204 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 573235015205 Hemerythrin-like domain; Region: Hr-like; cd12108 573235015206 Fe binding site [ion binding]; other site 573235015207 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 573235015208 EamA-like transporter family; Region: EamA; pfam00892 573235015209 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 573235015210 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 573235015211 NADP binding site [chemical binding]; other site 573235015212 Predicted transcriptional regulators [Transcription]; Region: COG1733 573235015213 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 573235015214 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 573235015215 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 573235015216 active site 573235015217 metal binding site [ion binding]; metal-binding site 573235015218 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 573235015219 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 573235015220 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 573235015221 active site 573235015222 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 573235015223 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 573235015224 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 573235015225 Domain of unknown function DUF21; Region: DUF21; pfam01595 573235015226 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 573235015227 Transporter associated domain; Region: CorC_HlyC; smart01091 573235015228 methionine sulfoxide reductase A; Provisional; Region: PRK00058 573235015229 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 573235015230 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 573235015231 Surface antigen; Region: Bac_surface_Ag; pfam01103 573235015232 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 573235015233 Family of unknown function (DUF490); Region: DUF490; pfam04357 573235015234 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 573235015235 putative active site pocket [active] 573235015236 dimerization interface [polypeptide binding]; other site 573235015237 putative catalytic residue [active] 573235015238 antitoxin ChpS; Provisional; Region: PRK11347 573235015239 toxin ChpB; Provisional; Region: PRK09812 573235015240 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 573235015241 dimer interface [polypeptide binding]; other site 573235015242 substrate binding site [chemical binding]; other site 573235015243 metal binding sites [ion binding]; metal-binding site 573235015244 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 573235015245 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 573235015246 putative ligand binding site [chemical binding]; other site 573235015247 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 573235015248 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 573235015249 Walker A/P-loop; other site 573235015250 ATP binding site [chemical binding]; other site 573235015251 Q-loop/lid; other site 573235015252 ABC transporter signature motif; other site 573235015253 Walker B; other site 573235015254 D-loop; other site 573235015255 H-loop/switch region; other site 573235015256 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 573235015257 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573235015258 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 573235015259 TM-ABC transporter signature motif; other site 573235015260 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573235015261 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 573235015262 TM-ABC transporter signature motif; other site 573235015263 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 573235015264 AMP binding site [chemical binding]; other site 573235015265 metal binding site [ion binding]; metal-binding site 573235015266 active site 573235015267 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 573235015268 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 573235015269 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 573235015270 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 573235015271 hypothetical protein; Provisional; Region: PRK05255 573235015272 peptidase PmbA; Provisional; Region: PRK11040 573235015273 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 573235015274 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573235015275 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 573235015276 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 573235015277 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 573235015278 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573235015279 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 573235015280 Transposase; Region: HTH_Tnp_1; pfam01527 573235015281 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 573235015282 cytochrome b562; Provisional; Region: PRK15058 573235015283 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 573235015284 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573235015285 FeS/SAM binding site; other site 573235015286 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 573235015287 ATP cone domain; Region: ATP-cone; pfam03477 573235015288 Class III ribonucleotide reductase; Region: RNR_III; cd01675 573235015289 effector binding site; other site 573235015290 active site 573235015291 Zn binding site [ion binding]; other site 573235015292 glycine loop; other site 573235015293 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 573235015294 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 573235015295 Ca binding site [ion binding]; other site 573235015296 active site 573235015297 catalytic site [active] 573235015298 fused trehalose(maltose)-specific PTS enzyme TreB:IIB component/IIC component, C-terminal part 573235015299 trehalose repressor; Provisional; Region: treR; PRK09492 573235015300 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573235015301 DNA binding site [nucleotide binding] 573235015302 domain linker motif; other site 573235015303 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 573235015304 dimerization interface [polypeptide binding]; other site 573235015305 ligand binding site [chemical binding]; other site 573235015306 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 573235015307 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 573235015308 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 573235015309 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 573235015310 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573235015311 motif II; other site 573235015312 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 573235015313 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 573235015314 Transposase; Region: DEDD_Tnp_IS110; pfam01548 573235015315 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 573235015316 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 573235015317 homotrimer interaction site [polypeptide binding]; other site 573235015318 putative active site [active] 573235015319 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 573235015320 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 573235015321 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 573235015322 aspartate carbamoyltransferase; Region: asp_carb_tr; TIGR00670 573235015323 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 573235015324 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 573235015325 PyrBI operon leader peptide; Region: PyrBI_leader; pfam08052 573235015326 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 573235015327 homotrimer interaction site [polypeptide binding]; other site 573235015328 putative active site [active] 573235015329 oxidoreductase; Provisional; Region: PRK12742 573235015330 classical (c) SDRs; Region: SDR_c; cd05233 573235015331 NAD(P) binding site [chemical binding]; other site 573235015332 active site 573235015333 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573235015334 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573235015335 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 573235015336 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 573235015337 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 573235015338 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 573235015339 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076 573235015340 RNase E inhibitor protein; Provisional; Region: PRK11191 573235015341 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 573235015342 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573235015343 Coenzyme A binding pocket [chemical binding]; other site 573235015344 conserved predicted inner membrane protein, N-terminal part 573235015345 conserved predicted inner membrane protein, C-terminal part 573235015346 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 573235015347 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 573235015348 HIGH motif; other site 573235015349 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 573235015350 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 573235015351 active site 573235015352 KMSKS motif; other site 573235015353 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 573235015354 tRNA binding surface [nucleotide binding]; other site 573235015355 anticodon binding site; other site 573235015356 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 573235015357 DNA polymerase III subunit chi; Validated; Region: PRK05728 573235015358 multifunctional aminopeptidase A; Provisional; Region: PRK00913 573235015359 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 573235015360 interface (dimer of trimers) [polypeptide binding]; other site 573235015361 Substrate-binding/catalytic site; other site 573235015362 Zn-binding sites [ion binding]; other site 573235015363 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 573235015364 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 573235015365 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 573235015366 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 573235015367 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 573235015368 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 573235015369 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 573235015370 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 573235015371 putative NAD(P) binding site [chemical binding]; other site 573235015372 putative substrate binding site [chemical binding]; other site 573235015373 catalytic Zn binding site [ion binding]; other site 573235015374 structural Zn binding site [ion binding]; other site 573235015375 dimer interface [polypeptide binding]; other site 573235015376 Prophage ECO26_P21, P4-like phage 573235015377 integrase; Provisional; Region: PRK09692 573235015378 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 573235015379 active site 573235015380 Int/Topo IB signature motif; other site 573235015381 Mannitol repressor; Region: MtlR; cl11450 573235015382 Transposase; Region: HTH_Tnp_1; pfam01527 573235015383 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 573235015384 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573235015385 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 573235015386 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 573235015387 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 573235015388 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573235015389 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 573235015390 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 573235015391 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 573235015392 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 573235015393 Phage polarity suppression protein (Psu); Region: Psu; pfam07455 573235015394 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 573235015395 Ash protein family; Region: Phage_ASH; pfam10554 573235015396 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 573235015397 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 573235015398 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 573235015399 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 573235015400 active site 573235015401 metal binding site [ion binding]; metal-binding site 573235015402 interdomain interaction site; other site 573235015403 D5 N terminal like; Region: D5_N; smart00885 573235015404 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 573235015405 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 573235015406 Integrative element ECO26_IE09 573235015407 Integrative element ECO26_IE09; predicted transposase OrfB protein of insertion sequence IS600, C-terminal fragment 573235015408 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 573235015409 Transposase; Region: HTH_Tnp_1; pfam01527 573235015410 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 573235015411 Transposase; Region: HTH_Tnp_1; cl17663 573235015412 Integrative element ECO26_IE09; OrfB protein of insertion sequence IS911, C-terminal fragment 573235015413 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 573235015414 iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231 573235015415 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 573235015416 Walker A/P-loop; other site 573235015417 ATP binding site [chemical binding]; other site 573235015418 Q-loop/lid; other site 573235015419 ABC transporter signature motif; other site 573235015420 Walker B; other site 573235015421 D-loop; other site 573235015422 H-loop/switch region; other site 573235015423 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 573235015424 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 573235015425 ABC-ATPase subunit interface; other site 573235015426 dimer interface [polypeptide binding]; other site 573235015427 putative PBP binding regions; other site 573235015428 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 573235015429 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 573235015430 dimer interface [polypeptide binding]; other site 573235015431 ABC-ATPase subunit interface; other site 573235015432 putative PBP binding regions; other site 573235015433 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 573235015434 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 573235015435 siderophore binding site; other site 573235015436 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 573235015437 Secretin and TonB N terminus short domain; Region: STN; smart00965 573235015438 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 573235015439 N-terminal plug; other site 573235015440 ligand-binding site [chemical binding]; other site 573235015441 fec operon regulator FecR; Reviewed; Region: PRK09774 573235015442 FecR protein; Region: FecR; pfam04773 573235015443 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 573235015444 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573235015445 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573235015446 DNA binding residues [nucleotide binding] 573235015447 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 573235015448 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 573235015449 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 573235015450 Integrative element ECO26_IE09; transposase InsAB' of insertion sequence IS1, N-terminal fragment 573235015451 Integrative element ECO26_IE09; transposase InsAB' of insertion sequence IS1, C-terminal fragment 573235015452 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 573235015453 Integrative element ECO26_IE09; predicted protein Orf3 in insertion sequence ISEc8, internal deletion 573235015454 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573235015455 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 573235015456 Transposase; Region: HTH_Tnp_1; pfam01527 573235015457 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 573235015458 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 573235015459 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 573235015460 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 573235015461 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 573235015462 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 573235015463 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573235015464 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 573235015465 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 573235015466 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 573235015467 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573235015468 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 573235015469 Transposase; Region: HTH_Tnp_1; pfam01527 573235015470 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 573235015471 Haemolysin expression modulating protein; Region: HHA; pfam05321 573235015472 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 573235015473 Integrative element ECO26_IE09; conserved predicted protein, N-terminal part 573235015474 Transposase; Region: HTH_Tnp_1; pfam01527 573235015475 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 573235015476 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573235015477 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 573235015478 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 573235015479 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573235015480 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 573235015481 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 573235015482 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 573235015483 Integrative element ECO26_IE09; conserved predicted protein, C-terminal part 573235015484 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 573235015485 Predicted GTPase [General function prediction only]; Region: COG3596 573235015486 YfjP GTPase; Region: YfjP; cd11383 573235015487 G1 box; other site 573235015488 GTP/Mg2+ binding site [chemical binding]; other site 573235015489 Switch I region; other site 573235015490 G2 box; other site 573235015491 Switch II region; other site 573235015492 G3 box; other site 573235015493 G4 box; other site 573235015494 G5 box; other site 573235015495 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 573235015496 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 573235015497 hypothetical protein; Provisional; Region: PRK09945 573235015498 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 573235015499 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 573235015500 Autotransporter beta-domain; Region: Autotransporter; smart00869 573235015501 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 573235015502 Transposase; Region: HTH_Tnp_1; pfam01527 573235015503 Integrative element ECO26_IE09; transposase OrfB protein of insertion sequence IS600, C-terminal fragment 573235015504 Integrative element ECO26_IE09; predicted protein, C-terminal part 573235015505 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 573235015506 Domain of unknown function (DUF932); Region: DUF932; pfam06067 573235015507 Antirestriction protein; Region: Antirestrict; pfam03230 573235015508 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 573235015509 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 573235015510 MPN+ (JAMM) motif; other site 573235015511 Zinc-binding site [ion binding]; other site 573235015512 Protein of unknown function (DUF987); Region: DUF987; pfam06174 573235015513 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 573235015514 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 573235015515 Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117 573235015516 Integrative element ECO26_IE09; predicted protein, truncated 573235015517 Phage X family; Region: Phage_X; cl11585 573235015518 conserved predicted protein, truncated 573235015519 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183 573235015520 Domain of unknown function (DUF303); Region: DUF303; pfam03629 573235015521 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 573235015522 Kelch motif; Region: Kelch_1; pfam01344 573235015523 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 573235015524 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 573235015525 Int/Topo IB signature motif; other site 573235015526 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 573235015527 Int/Topo IB signature motif; other site 573235015528 Fimbrial protein; Region: Fimbrial; cl01416 573235015529 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 573235015530 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 573235015531 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 573235015532 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 573235015533 outer membrane usher protein; Provisional; Region: PRK15193 573235015534 PapC N-terminal domain; Region: PapC_N; pfam13954 573235015535 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 573235015536 PapC C-terminal domain; Region: PapC_C; pfam13953 573235015537 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 573235015538 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 573235015539 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 573235015540 mannosyl binding site [chemical binding]; other site 573235015541 Fimbrial protein; Region: Fimbrial; pfam00419 573235015542 mannonate dehydratase; Region: uxuA; TIGR00695 573235015543 mannonate dehydratase; Provisional; Region: PRK03906 573235015544 D-mannonate oxidoreductase; Provisional; Region: PRK15037 573235015545 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 573235015546 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 573235015547 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 573235015548 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573235015549 DNA-binding site [nucleotide binding]; DNA binding site 573235015550 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 573235015551 Protein of unknown function (DUF2686); Region: DUF2686; pfam10887 573235015552 DNA replication/recombination/repair protein; Provisional; Region: iraD; PRK14128 573235015553 cell density-dependent motility repressor; Provisional; Region: PRK10082 573235015554 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573235015555 LysR substrate binding domain; Region: LysR_substrate; pfam03466 573235015556 Isoaspartyl dipeptidase hydrolyzes the beta-L-isoaspartyl linkages in dipeptides, as part of the degradative pathway to eliminate proteins with beta-L-isoaspartyl peptide bonds, bonds whereby the beta-group of an aspartate forms the peptide link with the...; Region: Isoaspartyl-dipeptidase; cd01308 573235015557 isoaspartyl dipeptidase IadA; Region: isoAsp_dipep; TIGR01975 573235015558 dimer interface [polypeptide binding]; other site 573235015559 active site 573235015560 hypothetical protein; Provisional; Region: PRK10519 573235015561 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 573235015562 Nucleoside recognition; Region: Gate; pfam07670 573235015563 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 573235015564 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 573235015565 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573235015566 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235015567 putative substrate translocation pore; other site 573235015568 conserved predicted protein, C-terminal part 573235015569 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 573235015570 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 573235015571 CoA-substrate-specific enzyme activase, putative; Region: CoA_E_activ; TIGR00241 573235015572 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 573235015573 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 573235015574 Predicted membrane protein [Function unknown]; Region: COG2733 573235015575 multidrug efflux system protein MdtM; Provisional; Region: PRK15403 573235015576 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235015577 putative substrate translocation pore; other site 573235015578 putative transposase; Provisional; Region: PRK09857 573235015579 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 573235015580 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 573235015581 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573235015582 DNA-binding site [nucleotide binding]; DNA binding site 573235015583 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573235015584 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573235015585 homodimer interface [polypeptide binding]; other site 573235015586 catalytic residue [active] 573235015587 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 573235015588 conserved predicted protein, C-terminal part 573235015589 endoribonuclease SymE; Provisional; Region: PRK13605 573235015590 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 573235015591 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 573235015592 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 573235015593 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 573235015594 HsdM N-terminal domain; Region: HsdM_N; pfam12161 573235015595 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 573235015596 Methyltransferase domain; Region: Methyltransf_26; pfam13659 573235015597 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 573235015598 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 573235015599 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573235015600 ATP binding site [chemical binding]; other site 573235015601 putative Mg++ binding site [ion binding]; other site 573235015602 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 573235015603 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 573235015604 P-loop, Walker A motif; other site 573235015605 Base recognition motif; other site 573235015606 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 573235015607 Uncharacterized small protein [Function unknown]; Region: COG2879 573235015608 carbon starvation protein A; Provisional; Region: PRK15015 573235015609 Carbon starvation protein CstA; Region: CstA; pfam02554 573235015610 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 573235015611 4-hydroxyphenylacetate 3-monooxygenase reductase subunit; Provisional; Region: hpaC; PRK15486 573235015612 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 573235015613 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 573235015614 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 573235015615 Cupin domain; Region: Cupin_2; pfam07883 573235015616 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573235015617 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573235015618 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 573235015619 putative substrate translocation pore; other site 573235015620 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 573235015621 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312 573235015622 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 573235015623 putative substrate binding pocket [chemical binding]; other site 573235015624 trimer interface [polypeptide binding]; other site 573235015625 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 573235015626 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 573235015627 putative active site [active] 573235015628 putative metal binding site [ion binding]; other site 573235015629 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 573235015630 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 573235015631 NAD binding site [chemical binding]; other site 573235015632 catalytic residues [active] 573235015633 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase; Provisional; Region: PRK15203 573235015634 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, N-terminal subunit; Region: HpaG-N-term; TIGR02305 573235015635 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 573235015636 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 573235015637 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 573235015638 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 573235015639 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 573235015640 dimer interface [polypeptide binding]; other site 573235015641 ligand binding site [chemical binding]; other site 573235015642 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573235015643 dimerization interface [polypeptide binding]; other site 573235015644 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573235015645 dimer interface [polypeptide binding]; other site 573235015646 putative CheW interface [polypeptide binding]; other site 573235015647 DctM-like transporters; Region: DctM; pfam06808 573235015648 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 573235015649 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 573235015650 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 573235015651 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 573235015652 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 573235015653 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 573235015654 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573235015655 DNA-binding site [nucleotide binding]; DNA binding site 573235015656 Transcriptional regulators [Transcription]; Region: GntR; COG1802 573235015657 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 573235015658 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 573235015659 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 573235015660 putative NAD(P) binding site [chemical binding]; other site 573235015661 catalytic Zn binding site [ion binding]; other site 573235015662 structural Zn binding site [ion binding]; other site 573235015663 phosphoglycerol transferase I; Provisional; Region: PRK03776 573235015664 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 573235015665 hypothetical protein; Provisional; Region: PRK11667 573235015666 DNA replication protein DnaC; Validated; Region: PRK07952 573235015667 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573235015668 Walker A motif; other site 573235015669 ATP binding site [chemical binding]; other site 573235015670 Walker B motif; other site 573235015671 primosomal protein DnaI; Provisional; Region: PRK02854 573235015672 hypothetical protein; Provisional; Region: PRK09917 573235015673 Uncharacterized conserved protein [Function unknown]; Region: COG2966 573235015674 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 573235015675 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 573235015676 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573235015677 DNA binding residues [nucleotide binding] 573235015678 dimerization interface [polypeptide binding]; other site 573235015679 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 573235015680 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573235015681 DNA binding residues [nucleotide binding] 573235015682 dimerization interface [polypeptide binding]; other site 573235015683 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 573235015684 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 573235015685 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 573235015686 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 573235015687 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 573235015688 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 573235015689 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573235015690 S-adenosylmethionine binding site [chemical binding]; other site 573235015691 DNA polymerase III subunit psi; Validated; Region: PRK06856 573235015692 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 573235015693 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573235015694 Coenzyme A binding pocket [chemical binding]; other site 573235015695 dUMP phosphatase; Provisional; Region: PRK09449 573235015696 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573235015697 motif II; other site 573235015698 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 573235015699 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 573235015700 G1 box; other site 573235015701 putative GEF interaction site [polypeptide binding]; other site 573235015702 GTP/Mg2+ binding site [chemical binding]; other site 573235015703 Switch I region; other site 573235015704 G2 box; other site 573235015705 G3 box; other site 573235015706 Switch II region; other site 573235015707 G4 box; other site 573235015708 G5 box; other site 573235015709 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 573235015710 periplasmic protein; Provisional; Region: PRK10568 573235015711 BON domain; Region: BON; pfam04972 573235015712 BON domain; Region: BON; pfam04972 573235015713 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 573235015714 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 573235015715 active site 573235015716 nucleophile elbow; other site 573235015717 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 573235015718 active site 573235015719 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 573235015720 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573235015721 FeS/SAM binding site; other site 573235015722 hypothetical protein; Provisional; Region: PRK10977 573235015723 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 573235015724 intersubunit interface [polypeptide binding]; other site 573235015725 active site 573235015726 catalytic residue [active] 573235015727 thymidine phosphorylase DeoA, C-terminal fragment 573235015728 phosphopentomutase; Provisional; Region: PRK05362 573235015729 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 573235015730 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 573235015731 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 573235015732 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573235015733 non-specific DNA binding site [nucleotide binding]; other site 573235015734 salt bridge; other site 573235015735 sequence-specific DNA binding site [nucleotide binding]; other site 573235015736 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 573235015737 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 573235015738 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 573235015739 hypothetical protein; Provisional; Region: PRK11246 573235015740 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 573235015741 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573235015742 motif II; other site 573235015743 DNA repair protein RadA; Region: sms; TIGR00416 573235015744 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 573235015745 Walker A motif/ATP binding site; other site 573235015746 ATP binding site [chemical binding]; other site 573235015747 Walker B motif; other site 573235015748 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 573235015749 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573235015750 non-specific DNA binding site [nucleotide binding]; other site 573235015751 salt bridge; other site 573235015752 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 573235015753 sequence-specific DNA binding site [nucleotide binding]; other site 573235015754 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 573235015755 active site 573235015756 (T/H)XGH motif; other site 573235015757 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 573235015758 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 573235015759 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573235015760 Walker A/P-loop; other site 573235015761 ATP binding site [chemical binding]; other site 573235015762 Q-loop/lid; other site 573235015763 ABC transporter signature motif; other site 573235015764 Walker B; other site 573235015765 D-loop; other site 573235015766 H-loop/switch region; other site 573235015767 ABC transporter; Region: ABC_tran_2; pfam12848 573235015768 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 573235015769 lytic murein transglycosylase; Provisional; Region: PRK11619 573235015770 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 573235015771 N-acetyl-D-glucosamine binding site [chemical binding]; other site 573235015772 catalytic residue [active] 573235015773 Trp operon repressor; Provisional; Region: PRK01381 573235015774 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 573235015775 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 573235015776 catalytic core [active] 573235015777 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 573235015778 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573235015779 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 573235015780 hypothetical protein; Provisional; Region: PRK10756 573235015781 CreA protein; Region: CreA; pfam05981 573235015782 DNA-binding response regulator CreB; Provisional; Region: PRK11083 573235015783 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573235015784 active site 573235015785 phosphorylation site [posttranslational modification] 573235015786 intermolecular recognition site; other site 573235015787 dimerization interface [polypeptide binding]; other site 573235015788 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573235015789 DNA binding site [nucleotide binding] 573235015790 sensory histidine kinase CreC; Provisional; Region: PRK11100 573235015791 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573235015792 dimerization interface [polypeptide binding]; other site 573235015793 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573235015794 dimer interface [polypeptide binding]; other site 573235015795 phosphorylation site [posttranslational modification] 573235015796 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573235015797 ATP binding site [chemical binding]; other site 573235015798 Mg2+ binding site [ion binding]; other site 573235015799 G-X-G motif; other site 573235015800 Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452 573235015801 two-component response regulator; Provisional; Region: PRK11173 573235015802 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573235015803 active site 573235015804 phosphorylation site [posttranslational modification] 573235015805 intermolecular recognition site; other site 573235015806 dimerization interface [polypeptide binding]; other site 573235015807 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573235015808 DNA binding site [nucleotide binding] 573235015809 putative RNA methyltransferase; Provisional; Region: PRK10433 573235015810 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050 573235015811 replication protein; Provisional; Region: PRK13750 573235015812 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 573235015813 Putative transposase; Region: Y2_Tnp; pfam04986 573235015814 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 573235015815 Phosphotransferase enzyme family; Region: APH; pfam01636 573235015816 active site 573235015817 ATP binding site [chemical binding]; other site 573235015818 antibiotic binding site [chemical binding]; other site 573235015819 predicted transposase of transposon Tn21, central part 573235015820 modulator of post-segregation killing protein; Provisional; Region: PRK13720 573235015821 Plasmid stability protein; Region: Plasmid_stab_B; pfam10784 573235015822 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 573235015823 PRTRC system protein D; Region: PRTRC_D; TIGR03739 573235015824 Mg binding site [ion binding]; other site 573235015825 nucleotide binding site [chemical binding]; other site 573235015826 putative protofilament interface [polypeptide binding]; other site 573235015827 Protein of unknown function (DUF1281); Region: DUF1281; pfam06924 573235015828 putative methylase; Provisional; Region: PRK13699 573235015829 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 573235015830 Protein of unknown function (DUF1380); Region: DUF1380; pfam07128 573235015831 Protein of unknown function (DUF1472); Region: DUF1472; pfam07339 573235015832 Antirestriction protein; Region: Antirestrict; pfam03230 573235015833 Domain of unknown function (DUF3560); Region: DUF3560; pfam12083 573235015834 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573235015835 S-adenosylmethionine binding site [chemical binding]; other site 573235015836 conserved predicted protein, partial 573235015837 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 573235015838 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 573235015839 dimer interface [polypeptide binding]; other site 573235015840 ssDNA binding site [nucleotide binding]; other site 573235015841 tetramer (dimer of dimers) interface [polypeptide binding]; other site 573235015842 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 573235015843 ParB-like nuclease domain; Region: ParBc; pfam02195 573235015844 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 573235015845 KorB domain; Region: KorB; pfam08535 573235015846 plasmid SOS inhibition protein B; Provisional; Region: psiB; PRK13701 573235015847 plasmid SOS inhibition protein A; Provisional; Region: PRK13704 573235015848 small toxic polypeptide; Provisional; Region: PRK09738 573235015849 small toxic polypeptide; Provisional; Region: PRK09738 573235015850 excinuclease ABC subunit B; Provisional; Region: PRK05298 573235015851 Domain of unknown function (DUF932); Region: DUF932; pfam06067 573235015852 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 573235015853 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 573235015854 N-acetyl-D-glucosamine binding site [chemical binding]; other site 573235015855 catalytic residue [active] 573235015856 TraM protein; Region: Tra_M; pfam05261 573235015857 conjugal transfer transcriptional regulator TraJ; Provisional; Region: PRK13719 573235015858 conjugal transfer protein TraY; Provisional; Region: PRK13740 573235015859 conjugal transfer pilin subunit TraA; Provisional; Region: PRK13734 573235015860 conjugal transfer pilus assembly protein TraL; Provisional; Region: PRK13707 573235015861 conjugal transfer pilus assembly protein TraE; Provisional; Region: PRK13726 573235015862 conjugal transfer protein TraK; Provisional; Region: PRK13736 573235015863 TraK protein; Region: TraK; pfam06586 573235015864 conjugal transfer pilus assembly protein TraB; Provisional; Region: PRK13729 573235015865 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 573235015866 conjugal transfer protein TraP; Provisional; Region: PRK13739 573235015867 conjugal transfer protein TrbD; Provisional; Region: PRK13724 573235015868 conjugal transfer protein TrbG; Provisional; Region: PRK13744 573235015869 conjugal transfer protein TraV; Provisional; Region: PRK13733 573235015870 Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676 573235015871 conjugal transfer protein TraR; Provisional; Region: PRK13715 573235015872 conjugal transfer ATP-binding protein TraC; Provisional; Region: PRK13721 573235015873 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 573235015874 conjugal transfer protein TrbI; Provisional; Region: PRK13717 573235015875 conjugal transfer pilus assembly protein TraW; Provisional; Region: PRK13738 573235015876 conjugal transfer pilus assembly protein TraU; Provisional; Region: PRK13737 573235015877 conjugal transfer pilus assembly protein TrbC; Provisional; Region: PRK13730 573235015878 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 573235015879 active site 573235015880 conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355 573235015881 conjugal transfer protein TrbE; Provisional; Region: PRK13718 573235015882 conjugal pilus assembly protein TraF; Provisional; Region: PRK13703 573235015883 F plasmid transfer operon protein; Region: TraF; pfam13728 573235015884 conjugal transfer pilin chaperone TraQ; Provisional; Region: PRK13727 573235015885 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 573235015886 catalytic residues [active] 573235015887 conjugal transfer protein TrbJ; Provisional; Region: PRK13711 573235015888 conjugal transfer protein TrbF; Provisional; Region: PRK13743 573235015889 predicted conjugal transfer protein TraH, N-terminal part 573235015890 conjugal transfer protein TrbF; Provisional; Region: PRK13743 573235015891 conjugal transfer pilus assembly protein TraH; Provisional; Region: PRK13723 573235015892 conjugal transfer mating pair stabilization protein TraG; Provisional; Region: PRK13735 573235015893 Plasmid conjugative transfer entry exclusion protein TraS; Region: TraS; pfam10624 573235015894 conjugal transfer surface exclusion protein TraT; Provisional; Region: PRK13731 573235015895 Enterobacterial TraT complement resistance protein; Region: TraT; pfam05818 573235015896 conjugal transfer protein TraD; Provisional; Region: PRK13700 573235015897 F sex factor protein N terminal; Region: TraD_N; pfam12615 573235015898 Bacterial conjugation protein TrwB, ATP binding domain. TrwB is a homohexamer encoded by conjugative plasmids in Gram-negative bacteria. TrwB also has an all alpha domain which has been hypothesized to be responsible for DNA binding. TrwB is a component...; Region: TrwB; cd01127 573235015899 multimer interface [polypeptide binding]; other site 573235015900 Walker A motif; other site 573235015901 ATP binding site [chemical binding]; other site 573235015902 Walker B motif; other site 573235015903 conjugal transfer nickase/helicase TraI; Provisional; Region: PRK13709 573235015904 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 573235015905 AAA domain; Region: AAA_30; pfam13604 573235015906 DNA helicase TraI; Region: TraI; pfam07057 573235015907 conjugal transfer pilus acetylation protein TraX; Provisional; Region: PRK13706 573235015908 conjugal transfer fertility inhibition protein FinO; Provisional; Region: PRK13754 573235015909 Fertility inhibition protein N terminal; Region: FinO_N; pfam12602 573235015910 FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cd00236 573235015911 putative RNA binding sites [nucleotide binding]; other site 573235015912 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 573235015913 Hok/gef family; Region: HOK_GEF; pfam01848 573235015914 replication protein; Provisional; Region: PRK13702 573235015915 Rop protein; Region: Rop; pfam01815 573235015916 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 573235015917 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 573235015918 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 573235015919 DNA methylase; Region: N6_N4_Mtase; pfam01555 573235015920 CfrBI restriction endonuclease; Region: RE_CfrBI; pfam09516 573235015921 RTX toxin acyltransferase family; Region: HlyC; pfam02794 573235015922 RTX N-terminal domain; Region: RTX; pfam02382 573235015923 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 573235015924 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 573235015925 RTX C-terminal domain; Region: RTX_C; pfam08339 573235015926 A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine...; Region: Peptidase_C39_likeA; cd02417 573235015927 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 573235015928 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573235015929 ATP-binding cassette domain of hemolysin B, subfamily C; Region: ABCC_Hemolysin; cd03252 573235015930 Walker A/P-loop; other site 573235015931 ATP binding site [chemical binding]; other site 573235015932 Q-loop/lid; other site 573235015933 ABC transporter signature motif; other site 573235015934 Walker B; other site 573235015935 D-loop; other site 573235015936 H-loop/switch region; other site 573235015937 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 573235015938 HlyD family secretion protein; Region: HlyD_3; pfam13437 573235015939 YebF-like protein; Region: YebF; cl10126 573235015940 Phage integrase family; Region: Phage_integrase; pfam00589 573235015941 active site 573235015942 DNA binding site [nucleotide binding] 573235015943 Int/Topo IB signature motif; other site 573235015944 predicted protein, C-terminal part 573235015945 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 573235015946 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 573235015947 oligomeric interface; other site 573235015948 putative active site [active] 573235015949 homodimer interface [polypeptide binding]; other site 573235015950 predicted protein, C-terminal part 573235015951 predicted transposase OrfA protein of insertion sequence IS600, N-terminal fragment 573235015952 putative transposase OrfB; Reviewed; Region: PHA02517 573235015953 Integrase core domain; Region: rve; pfam00665 573235015954 Integrase core domain; Region: rve_3; pfam13683 573235015955 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 573235015956 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 573235015957 putative site-specific recombinase, N-terminal part 573235015958 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 573235015959 Homeodomain-like domain; Region: HTH_23; pfam13384 573235015960 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 573235015961 Transposase; Region: HTH_Tnp_1; pfam01527 573235015962 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 573235015963 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573235015964 predicted protein Orf3 in insertion sequence IS683, partial 573235015965 conserved predicted protein, N-terminal part 573235015966 Protein of unknown function (DUF2913); Region: DUF2913; pfam11140 573235015967 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), AnFA1; Region: NGN_SP_AnfA1; cd09894 573235015968 transcriptional activator RfaH; Region: RfaH; TIGR01955 573235015969 IncFII RepA protein family; Region: IncFII_repA; cl11495 573235015970 TcdB toxin N-terminal helical domain; Region: TcdB_N; pfam12918 573235015971 TcdA/TcdB catalytic glycosyltransferase domain; Region: TcdA_TcdB; pfam12919 573235015972 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 573235015973 cysteine protease domain, YopT-type; Region: yopT_cys_prot; TIGR01586 573235015974 Protein of unknown function (DUF3491); Region: DUF3491; pfam11996 573235015975 predicted protein Orf3 in insertion sequence IS682, central part 573235015976 predicted protein Orf3 in insertion sequence IS682, central part 573235015977 predicted protein Orf3 in insertion sequence IS682, central part 573235015978 putative OrfB protein of insertion sequence IS911, C-terminal fragment 573235015979 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 573235015980 Transposase; Region: HTH_Tnp_1; pfam01527 573235015981 predicted protein Orf1 in insertion sequence IS682, C-terminal disrupted 573235015982 predicted transposase, C-terminal fragment 573235015983 predicted transposase, central part 573235015984 predicted transposase, N-terminal fragment 573235015985 putative transposase of insertion sequence IS91, C-terminal fragment 573235015986 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 573235015987 Putative transposase; Region: Y2_Tnp; pfam04986 573235015988 predicted site-specific recombinase, C-terminal part 573235015989 predicted protein Orf3 in insertion sequence IS683, partial 573235015990 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 573235015991 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573235015992 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 573235015993 Homeodomain-like domain; Region: HTH_23; pfam13384 573235015994 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 573235015995 Transposase; Region: HTH_Tnp_1; pfam01527 573235015996 predicted protein Orf1 in insertion sequence ISEc8, N-terminal fragment 573235015997 Initiator Replication protein; Region: Rep_3; cl03080 573235015998 Transposase; Region: HTH_Tnp_1; cl17663 573235015999 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 573235016000 putative transposase OrfB; Reviewed; Region: PHA02517 573235016001 HTH-like domain; Region: HTH_21; pfam13276 573235016002 Integrase core domain; Region: rve; pfam00665 573235016003 Integrase core domain; Region: rve_3; pfam13683 573235016004 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 573235016005 dimer interface [polypeptide binding]; other site 573235016006 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 573235016007 active site 573235016008 heme binding site [chemical binding]; other site 573235016009 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 573235016010 Cytochrome b562; Region: Cytochrom_B562; pfam07361 573235016011 predicted transposase OrfA protein of insertion sequence IS629, N-terminal disrupted 573235016012 predicted transposase OrfB protein of insertion sequence IS629, N-terminal part 573235016013 predicted transposase OrfB protein of insertion sequence IS629, central part 573235016014 Plasmid stability protein; Region: Plasmid_stab_B; pfam10784 573235016015 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 573235016016 PRTRC system protein D; Region: PRTRC_D; TIGR03739 573235016017 Mg binding site [ion binding]; other site 573235016018 nucleotide binding site [chemical binding]; other site 573235016019 putative protofilament interface [polypeptide binding]; other site 573235016020 Protein of unknown function (DUF1281); Region: DUF1281; pfam06924 573235016021 putative methylase; Provisional; Region: PRK13699 573235016022 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 573235016023 Protein of unknown function (DUF1380); Region: DUF1380; pfam07128 573235016024 Plasmid SOS inhibition protein (PsiB); Region: PsiB; cl11633 573235016025 PsiA protein; Region: PsiA; cl11646 573235016026 conserved predicted protein, C-terminal part 573235016027 conserved predicted protein, N-terminal part 573235016028 Antirestriction protein (ArdA); Region: ArdA; pfam07275 573235016029 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07003 573235016030 putative transposase; Provisional; Region: PRK09857 573235016031 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 573235016032 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 573235016033 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 573235016034 non-specific DNA binding site [nucleotide binding]; other site 573235016035 salt bridge; other site 573235016036 sequence-specific DNA binding site [nucleotide binding]; other site 573235016037 Methyltransferase domain; Region: Methyltransf_27; pfam13708 573235016038 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 573235016039 predicted TrbC protein, C-terminal part 573235016040 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 573235016041 Transposase; Region: HTH_Tnp_1; pfam01527 573235016042 predicted transposase OrfB protein of insertion sequence IS600, C-terminal fragment 573235016043 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 573235016044 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 573235016045 site-specific recombinase, N-terminal part 573235016046 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 573235016047 Homeodomain-like domain; Region: HTH_23; pfam13384 573235016048 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 573235016049 Transposase; Region: HTH_Tnp_1; pfam01527 573235016050 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 573235016051 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573235016052 predicted protein Orf3 in insertion sequence IS683, partial 573235016053 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 573235016054 Putative transposase; Region: Y2_Tnp; pfam04986 573235016055 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573235016056 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 573235016057 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 573235016058 homodimer interface [polypeptide binding]; other site 573235016059 putative GKAP docking site [polypeptide binding]; other site 573235016060 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 573235016061 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573235016062 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 573235016063 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 573235016064 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 573235016065 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 573235016066 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 573235016067 putative acyl-acceptor binding pocket; other site 573235016068 hypothetical protein; Provisional; Region: PRK10649 573235016069 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 573235016070 Sulfatase; Region: Sulfatase; pfam00884 573235016071 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573235016072 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 573235016073 Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969 573235016074 putative active site [active] 573235016075 putative metal binding site [ion binding]; other site 573235016076 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 573235016077 Transposase; Region: HTH_Tnp_1; cl17663 573235016078 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 573235016079 putative transposase OrfB protein of insertion sequence IS629, N-terminal fragment 573235016080 Rop protein; Region: Rop; pfam01815 573235016081 Abi-like protein; Region: Abi_2; pfam07751