-- dump date 20140619_090151 -- class Genbank::misc_feature -- table misc_feature_note -- id note 701177000001 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 701177000002 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 701177000003 putative catalytic residues [active] 701177000004 putative nucleotide binding site [chemical binding]; other site 701177000005 putative aspartate binding site [chemical binding]; other site 701177000006 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 701177000007 dimer interface [polypeptide binding]; other site 701177000008 putative threonine allosteric regulatory site; other site 701177000009 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 701177000010 putative threonine allosteric regulatory site; other site 701177000011 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 701177000012 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 701177000013 homoserine kinase; Region: thrB; TIGR00191 701177000014 Protein of unknown function; Region: YhfT; pfam10797 701177000015 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 701177000016 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 701177000017 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 701177000018 pyridoxal 5'-phosphate binding site [chemical binding]; other site 701177000019 catalytic residue [active] 701177000020 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 701177000021 hypothetical protein; Validated; Region: PRK02101 701177000022 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 701177000023 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 701177000024 transaldolase-like protein; Provisional; Region: PTZ00411 701177000025 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 701177000026 active site 701177000027 dimer interface [polypeptide binding]; other site 701177000028 catalytic residue [active] 701177000029 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 701177000030 MPT binding site; other site 701177000031 trimer interface [polypeptide binding]; other site 701177000032 hypothetical protein; Provisional; Region: PRK10659 701177000033 hypothetical protein; Provisional; Region: PRK10154 701177000034 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 701177000035 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 701177000036 nucleotide binding site [chemical binding]; other site 701177000037 NEF interaction site [polypeptide binding]; other site 701177000038 SBD interface [polypeptide binding]; other site 701177000039 chaperone protein DnaJ; Provisional; Region: PRK10767 701177000040 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 701177000041 HSP70 interaction site [polypeptide binding]; other site 701177000042 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 701177000043 substrate binding site [polypeptide binding]; other site 701177000044 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 701177000045 Zn binding sites [ion binding]; other site 701177000046 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 701177000047 dimer interface [polypeptide binding]; other site 701177000048 Hok/gef family; Region: HOK_GEF; pfam01848 701177000049 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 701177000050 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 701177000051 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 701177000052 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 701177000053 putative dimerization interface [polypeptide binding]; other site 701177000054 fimbrial outer membrane usher protein; Provisional; Region: PRK15217 701177000055 PapC N-terminal domain; Region: PapC_N; pfam13954 701177000056 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 701177000057 PapC C-terminal domain; Region: PapC_C; pfam13953 701177000058 putative fimbrial assembly chaperone protein StcB; Provisional; Region: PRK15253 701177000059 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 701177000060 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 701177000061 Fimbrial protein; Region: Fimbrial; cl01416 701177000062 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 701177000063 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 701177000064 Protein of unknown function (DUF2575); Region: DUF2575; pfam10837 701177000065 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 701177000066 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 701177000067 active site 701177000068 Riboflavin kinase; Region: Flavokinase; smart00904 701177000069 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 701177000070 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 701177000071 HIGH motif; other site 701177000072 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 701177000073 active site 701177000074 KMSKS motif; other site 701177000075 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 701177000076 tRNA binding surface [nucleotide binding]; other site 701177000077 anticodon binding site; other site 701177000078 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 701177000079 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 701177000080 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 701177000081 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 701177000082 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 701177000083 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 701177000084 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 701177000085 active site 701177000086 tetramer interface [polypeptide binding]; other site 701177000087 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 701177000088 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 701177000089 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 701177000090 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 701177000091 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 701177000092 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 701177000093 catalytic site [active] 701177000094 subunit interface [polypeptide binding]; other site 701177000095 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 701177000096 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 701177000097 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 701177000098 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 701177000099 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 701177000100 ATP-grasp domain; Region: ATP-grasp_4; cl17255 701177000101 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 701177000102 IMP binding site; other site 701177000103 dimer interface [polypeptide binding]; other site 701177000104 interdomain contacts; other site 701177000105 partial ornithine binding site; other site 701177000106 DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476 701177000107 carnitine operon protein CaiE; Provisional; Region: PRK13627 701177000108 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 701177000109 putative trimer interface [polypeptide binding]; other site 701177000110 putative metal binding site [ion binding]; other site 701177000111 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 701177000112 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 701177000113 substrate binding site [chemical binding]; other site 701177000114 oxyanion hole (OAH) forming residues; other site 701177000115 trimer interface [polypeptide binding]; other site 701177000116 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 701177000117 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 701177000118 acyl-activating enzyme (AAE) consensus motif; other site 701177000119 putative AMP binding site [chemical binding]; other site 701177000120 putative active site [active] 701177000121 putative CoA binding site [chemical binding]; other site 701177000122 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 701177000123 CoA-transferase family III; Region: CoA_transf_3; pfam02515 701177000124 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 701177000125 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 701177000126 active site 701177000127 L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356 701177000128 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 701177000129 Ligand binding site [chemical binding]; other site 701177000130 Electron transfer flavoprotein domain; Region: ETF; pfam01012 701177000131 putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363 701177000132 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985 701177000133 Ligand binding site [chemical binding]; other site 701177000134 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 701177000135 putative oxidoreductase FixC; Provisional; Region: PRK10157 701177000136 ferredoxin-like protein FixX; Provisional; Region: PRK15449 701177000137 benzoate transport; Region: 2A0115; TIGR00895 701177000138 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177000139 putative substrate translocation pore; other site 701177000140 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 701177000141 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 701177000142 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 701177000143 TrkA-N domain; Region: TrkA_N; pfam02254 701177000144 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 701177000145 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 701177000146 folate binding site [chemical binding]; other site 701177000147 NADP+ binding site [chemical binding]; other site 701177000148 Post-segregation antitoxin CcdA; Region: CcdA; pfam07362 701177000149 CcdB protein; Region: CcdB; pfam01845 701177000150 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 701177000151 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 701177000152 active site 701177000153 metal binding site [ion binding]; metal-binding site 701177000154 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 701177000155 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 701177000156 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 701177000157 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 701177000158 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 701177000159 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 701177000160 SurA N-terminal domain; Region: SurA_N; pfam09312 701177000161 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 701177000162 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 701177000163 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 701177000164 OstA-like protein; Region: OstA; pfam03968 701177000165 Organic solvent tolerance protein; Region: OstA_C; pfam04453 701177000166 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 701177000167 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 701177000168 putative metal binding site [ion binding]; other site 701177000169 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 701177000170 HSP70 interaction site [polypeptide binding]; other site 701177000171 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 701177000172 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 701177000173 active site 701177000174 ATP-dependent helicase HepA; Validated; Region: PRK04914 701177000175 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 701177000176 ATP binding site [chemical binding]; other site 701177000177 putative Mg++ binding site [ion binding]; other site 701177000178 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 701177000179 nucleotide binding region [chemical binding]; other site 701177000180 ATP-binding site [chemical binding]; other site 701177000181 DNA polymerase II; Reviewed; Region: PRK05762 701177000182 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 701177000183 active site 701177000184 catalytic site [active] 701177000185 substrate binding site [chemical binding]; other site 701177000186 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 701177000187 active site 701177000188 metal-binding site 701177000189 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 701177000190 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 701177000191 intersubunit interface [polypeptide binding]; other site 701177000192 active site 701177000193 Zn2+ binding site [ion binding]; other site 701177000194 L-arabinose isomerase; Provisional; Region: PRK02929 701177000195 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 701177000196 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 701177000197 trimer interface [polypeptide binding]; other site 701177000198 putative substrate binding site [chemical binding]; other site 701177000199 putative metal binding site [ion binding]; other site 701177000200 ribulokinase; Provisional; Region: PRK04123 701177000201 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 701177000202 N- and C-terminal domain interface [polypeptide binding]; other site 701177000203 active site 701177000204 MgATP binding site [chemical binding]; other site 701177000205 catalytic site [active] 701177000206 metal binding site [ion binding]; metal-binding site 701177000207 carbohydrate binding site [chemical binding]; other site 701177000208 homodimer interface [polypeptide binding]; other site 701177000209 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 701177000210 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 701177000211 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 701177000212 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 701177000213 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 701177000214 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 701177000215 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 701177000216 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 701177000217 Walker A/P-loop; other site 701177000218 ATP binding site [chemical binding]; other site 701177000219 Q-loop/lid; other site 701177000220 ABC transporter signature motif; other site 701177000221 Walker B; other site 701177000222 D-loop; other site 701177000223 H-loop/switch region; other site 701177000224 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 701177000225 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 701177000226 dimer interface [polypeptide binding]; other site 701177000227 conserved gate region; other site 701177000228 putative PBP binding loops; other site 701177000229 ABC-ATPase subunit interface; other site 701177000230 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 701177000231 dimer interface [polypeptide binding]; other site 701177000232 conserved gate region; other site 701177000233 putative PBP binding loops; other site 701177000234 ABC-ATPase subunit interface; other site 701177000235 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 701177000236 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 701177000237 transcriptional regulator SgrR; Provisional; Region: PRK13626 701177000238 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 701177000239 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 701177000240 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 701177000241 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 701177000242 substrate binding site [chemical binding]; other site 701177000243 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 701177000244 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 701177000245 substrate binding site [chemical binding]; other site 701177000246 ligand binding site [chemical binding]; other site 701177000247 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 701177000248 tartrate dehydrogenase; Region: TTC; TIGR02089 701177000249 2-isopropylmalate synthase; Validated; Region: PRK00915 701177000250 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 701177000251 active site 701177000252 catalytic residues [active] 701177000253 metal binding site [ion binding]; metal-binding site 701177000254 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 701177000255 leu operon leader peptide; Provisional; Region: PRK09925 701177000256 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 701177000257 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 701177000258 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 701177000259 putative substrate binding pocket [chemical binding]; other site 701177000260 putative dimerization interface [polypeptide binding]; other site 701177000261 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 701177000262 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 701177000263 PYR/PP interface [polypeptide binding]; other site 701177000264 dimer interface [polypeptide binding]; other site 701177000265 TPP binding site [chemical binding]; other site 701177000266 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 701177000267 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 701177000268 TPP-binding site [chemical binding]; other site 701177000269 dimer interface [polypeptide binding]; other site 701177000270 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 701177000271 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 701177000272 putative valine binding site [chemical binding]; other site 701177000273 dimer interface [polypeptide binding]; other site 701177000274 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 701177000275 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 701177000276 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 701177000277 DNA binding site [nucleotide binding] 701177000278 domain linker motif; other site 701177000279 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 701177000280 dimerization interface [polypeptide binding]; other site 701177000281 ligand binding site [chemical binding]; other site 701177000282 mraZ protein; Region: TIGR00242 701177000283 MraZ protein; Region: MraZ; pfam02381 701177000284 MraZ protein; Region: MraZ; pfam02381 701177000285 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 701177000286 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 701177000287 cell division protein FtsL; Provisional; Region: PRK10772 701177000288 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 701177000289 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 701177000290 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 701177000291 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 701177000292 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 701177000293 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 701177000294 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 701177000295 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 701177000296 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 701177000297 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 701177000298 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 701177000299 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 701177000300 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 701177000301 Mg++ binding site [ion binding]; other site 701177000302 putative catalytic motif [active] 701177000303 putative substrate binding site [chemical binding]; other site 701177000304 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 701177000305 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 701177000306 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 701177000307 cell division protein FtsW; Provisional; Region: PRK10774 701177000308 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 701177000309 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 701177000310 active site 701177000311 homodimer interface [polypeptide binding]; other site 701177000312 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 701177000313 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 701177000314 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 701177000315 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 701177000316 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 701177000317 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 701177000318 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 701177000319 cell division protein FtsQ; Provisional; Region: PRK10775 701177000320 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 701177000321 Cell division protein FtsQ; Region: FtsQ; pfam03799 701177000322 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 701177000323 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 701177000324 Cell division protein FtsA; Region: FtsA; pfam14450 701177000325 cell division protein FtsZ; Validated; Region: PRK09330 701177000326 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 701177000327 nucleotide binding site [chemical binding]; other site 701177000328 SulA interaction site; other site 701177000329 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 701177000330 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 701177000331 SecA regulator SecM; Provisional; Region: PRK02943 701177000332 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 701177000333 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 701177000334 SEC-C motif; Region: SEC-C; pfam02810 701177000335 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 701177000336 active site 701177000337 8-oxo-dGMP binding site [chemical binding]; other site 701177000338 nudix motif; other site 701177000339 metal binding site [ion binding]; metal-binding site 701177000340 DNA gyrase inhibitor; Reviewed; Region: PRK00418 701177000341 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 701177000342 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 701177000343 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 701177000344 CoA-binding site [chemical binding]; other site 701177000345 ATP-binding [chemical binding]; other site 701177000346 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 701177000347 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 701177000348 active site 701177000349 type IV pilin biogenesis protein; Provisional; Region: PRK10573 701177000350 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 701177000351 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 701177000352 putative major pilin subunit; Provisional; Region: PRK10574 701177000353 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 701177000354 Pilin (bacterial filament); Region: Pilin; pfam00114 701177000355 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 701177000356 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 701177000357 dimerization interface [polypeptide binding]; other site 701177000358 active site 701177000359 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 701177000360 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 701177000361 amidase catalytic site [active] 701177000362 Zn binding residues [ion binding]; other site 701177000363 substrate binding site [chemical binding]; other site 701177000364 regulatory protein AmpE; Provisional; Region: PRK10987 701177000365 aromatic amino acid transporter; Provisional; Region: PRK10238 701177000366 Transcriptional regulators [Transcription]; Region: FadR; COG2186 701177000367 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 701177000368 DNA-binding site [nucleotide binding]; DNA binding site 701177000369 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 701177000370 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 701177000371 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 701177000372 dimer interface [polypeptide binding]; other site 701177000373 TPP-binding site [chemical binding]; other site 701177000374 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 701177000375 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 701177000376 E3 interaction surface; other site 701177000377 lipoyl attachment site [posttranslational modification]; other site 701177000378 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 701177000379 E3 interaction surface; other site 701177000380 lipoyl attachment site [posttranslational modification]; other site 701177000381 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 701177000382 E3 interaction surface; other site 701177000383 lipoyl attachment site [posttranslational modification]; other site 701177000384 e3 binding domain; Region: E3_binding; pfam02817 701177000385 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 701177000386 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 701177000387 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 701177000388 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 701177000389 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 701177000390 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 701177000391 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 701177000392 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 701177000393 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 701177000394 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 701177000395 substrate binding site [chemical binding]; other site 701177000396 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 701177000397 substrate binding site [chemical binding]; other site 701177000398 ligand binding site [chemical binding]; other site 701177000399 hypothetical protein; Provisional; Region: PRK05248 701177000400 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 701177000401 spermidine synthase; Provisional; Region: PRK00811 701177000402 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 701177000403 S-adenosylmethionine binding site [chemical binding]; other site 701177000404 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 701177000405 multicopper oxidase; Provisional; Region: PRK10965 701177000406 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 701177000407 Multicopper oxidase; Region: Cu-oxidase; pfam00394 701177000408 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 701177000409 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 701177000410 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 701177000411 Trp docking motif [polypeptide binding]; other site 701177000412 putative active site [active] 701177000413 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 701177000414 active site 701177000415 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 701177000416 active site clefts [active] 701177000417 zinc binding site [ion binding]; other site 701177000418 dimer interface [polypeptide binding]; other site 701177000419 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 701177000420 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 701177000421 Walker A/P-loop; other site 701177000422 ATP binding site [chemical binding]; other site 701177000423 Q-loop/lid; other site 701177000424 ABC transporter signature motif; other site 701177000425 Walker B; other site 701177000426 D-loop; other site 701177000427 H-loop/switch region; other site 701177000428 inner membrane transport permease; Provisional; Region: PRK15066 701177000429 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 701177000430 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 701177000431 active pocket/dimerization site; other site 701177000432 active site 701177000433 phosphorylation site [posttranslational modification] 701177000434 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 701177000435 putative active site [active] 701177000436 putative metal binding site [ion binding]; other site 701177000437 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 701177000438 tetramerization interface [polypeptide binding]; other site 701177000439 active site 701177000440 Uncharacterized conserved protein [Function unknown]; Region: COG5464 701177000441 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 701177000442 pantoate--beta-alanine ligase; Region: panC; TIGR00018 701177000443 Pantoate-beta-alanine ligase; Region: PanC; cd00560 701177000444 active site 701177000445 ATP-binding site [chemical binding]; other site 701177000446 pantoate-binding site; other site 701177000447 HXXH motif; other site 701177000448 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 701177000449 oligomerization interface [polypeptide binding]; other site 701177000450 active site 701177000451 metal binding site [ion binding]; metal-binding site 701177000452 Fimbrial protein; Region: Fimbrial; cl01416 701177000453 putative fimbrial protein StaF; Provisional; Region: PRK15262 701177000454 putative fimbrial protein StaE; Provisional; Region: PRK15263 701177000455 Fimbrial protein; Region: Fimbrial; cl01416 701177000456 putative fimbrial outer membrane usher protein; Provisional; Region: PRK09828 701177000457 PapC N-terminal domain; Region: PapC_N; pfam13954 701177000458 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 701177000459 PapC C-terminal domain; Region: PapC_C; pfam13953 701177000460 putative chaperone protein EcpD; Provisional; Region: PRK09926 701177000461 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 701177000462 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 701177000463 Fimbrial protein; Region: Fimbrial; cl01416 701177000464 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 701177000465 catalytic center binding site [active] 701177000466 ATP binding site [chemical binding]; other site 701177000467 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 701177000468 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 701177000469 active site 701177000470 NTP binding site [chemical binding]; other site 701177000471 metal binding triad [ion binding]; metal-binding site 701177000472 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 701177000473 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 701177000474 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 701177000475 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 701177000476 active site 701177000477 nucleotide binding site [chemical binding]; other site 701177000478 HIGH motif; other site 701177000479 KMSKS motif; other site 701177000480 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 701177000481 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 701177000482 2'-5' RNA ligase; Provisional; Region: PRK15124 701177000483 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 701177000484 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 701177000485 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 701177000486 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 701177000487 ATP binding site [chemical binding]; other site 701177000488 putative Mg++ binding site [ion binding]; other site 701177000489 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 701177000490 nucleotide binding region [chemical binding]; other site 701177000491 ATP-binding site [chemical binding]; other site 701177000492 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 701177000493 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 701177000494 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 701177000495 Transglycosylase; Region: Transgly; pfam00912 701177000496 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 701177000497 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 701177000498 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 701177000499 N-terminal plug; other site 701177000500 ligand-binding site [chemical binding]; other site 701177000501 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 701177000502 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 701177000503 Walker A/P-loop; other site 701177000504 ATP binding site [chemical binding]; other site 701177000505 Q-loop/lid; other site 701177000506 ABC transporter signature motif; other site 701177000507 Walker B; other site 701177000508 D-loop; other site 701177000509 H-loop/switch region; other site 701177000510 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 701177000511 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 701177000512 siderophore binding site; other site 701177000513 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 701177000514 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 701177000515 ABC-ATPase subunit interface; other site 701177000516 dimer interface [polypeptide binding]; other site 701177000517 putative PBP binding regions; other site 701177000518 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 701177000519 ABC-ATPase subunit interface; other site 701177000520 dimer interface [polypeptide binding]; other site 701177000521 putative PBP binding regions; other site 701177000522 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 701177000523 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 701177000524 inhibitor-cofactor binding pocket; inhibition site 701177000525 pyridoxal 5'-phosphate binding site [chemical binding]; other site 701177000526 catalytic residue [active] 701177000527 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 701177000528 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 701177000529 Cl- selectivity filter; other site 701177000530 Cl- binding residues [ion binding]; other site 701177000531 pore gating glutamate residue; other site 701177000532 dimer interface [polypeptide binding]; other site 701177000533 H+/Cl- coupling transport residue; other site 701177000534 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 701177000535 hypothetical protein; Provisional; Region: PRK10578 701177000536 UPF0126 domain; Region: UPF0126; pfam03458 701177000537 UPF0126 domain; Region: UPF0126; pfam03458 701177000538 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 701177000539 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 701177000540 cobalamin binding residues [chemical binding]; other site 701177000541 putative BtuC binding residues; other site 701177000542 dimer interface [polypeptide binding]; other site 701177000543 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 701177000544 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 701177000545 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 701177000546 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 701177000547 Zn2+ binding site [ion binding]; other site 701177000548 Mg2+ binding site [ion binding]; other site 701177000549 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 701177000550 serine endoprotease; Provisional; Region: PRK10942 701177000551 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 701177000552 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 701177000553 protein binding site [polypeptide binding]; other site 701177000554 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 701177000555 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 701177000556 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 701177000557 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 701177000558 hypothetical protein; Provisional; Region: PRK13677 701177000559 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 701177000560 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 701177000561 trimer interface [polypeptide binding]; other site 701177000562 active site 701177000563 substrate binding site [chemical binding]; other site 701177000564 CoA binding site [chemical binding]; other site 701177000565 PII uridylyl-transferase; Provisional; Region: PRK05007 701177000566 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 701177000567 metal binding triad; other site 701177000568 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 701177000569 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 701177000570 Zn2+ binding site [ion binding]; other site 701177000571 Mg2+ binding site [ion binding]; other site 701177000572 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 701177000573 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 701177000574 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 701177000575 active site 701177000576 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 701177000577 rRNA interaction site [nucleotide binding]; other site 701177000578 S8 interaction site; other site 701177000579 putative laminin-1 binding site; other site 701177000580 elongation factor Ts; Provisional; Region: tsf; PRK09377 701177000581 UBA/TS-N domain; Region: UBA; pfam00627 701177000582 Elongation factor TS; Region: EF_TS; pfam00889 701177000583 Elongation factor TS; Region: EF_TS; pfam00889 701177000584 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 701177000585 putative nucleotide binding site [chemical binding]; other site 701177000586 uridine monophosphate binding site [chemical binding]; other site 701177000587 homohexameric interface [polypeptide binding]; other site 701177000588 ribosome recycling factor; Reviewed; Region: frr; PRK00083 701177000589 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 701177000590 hinge region; other site 701177000591 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 701177000592 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 701177000593 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 701177000594 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 701177000595 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 701177000596 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 701177000597 catalytic residue [active] 701177000598 putative FPP diphosphate binding site; other site 701177000599 putative FPP binding hydrophobic cleft; other site 701177000600 dimer interface [polypeptide binding]; other site 701177000601 putative IPP diphosphate binding site; other site 701177000602 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 701177000603 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 701177000604 zinc metallopeptidase RseP; Provisional; Region: PRK10779 701177000605 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 701177000606 active site 701177000607 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 701177000608 protein binding site [polypeptide binding]; other site 701177000609 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 701177000610 putative substrate binding region [chemical binding]; other site 701177000611 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 701177000612 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 701177000613 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 701177000614 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 701177000615 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 701177000616 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 701177000617 Surface antigen; Region: Bac_surface_Ag; pfam01103 701177000618 periplasmic chaperone; Provisional; Region: PRK10780 701177000619 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 701177000620 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 701177000621 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 701177000622 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 701177000623 trimer interface [polypeptide binding]; other site 701177000624 active site 701177000625 UDP-GlcNAc binding site [chemical binding]; other site 701177000626 lipid binding site [chemical binding]; lipid-binding site 701177000627 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 701177000628 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 701177000629 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 701177000630 active site 701177000631 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 701177000632 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 701177000633 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 701177000634 RNA/DNA hybrid binding site [nucleotide binding]; other site 701177000635 active site 701177000636 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 701177000637 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 701177000638 putative active site [active] 701177000639 putative PHP Thumb interface [polypeptide binding]; other site 701177000640 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 701177000641 generic binding surface II; other site 701177000642 generic binding surface I; other site 701177000643 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 701177000644 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 701177000645 lysine decarboxylase LdcC; Provisional; Region: PRK15399 701177000646 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 701177000647 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 701177000648 homodimer interface [polypeptide binding]; other site 701177000649 pyridoxal 5'-phosphate binding site [chemical binding]; other site 701177000650 catalytic residue [active] 701177000651 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 701177000652 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 701177000653 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 701177000654 putative metal binding site [ion binding]; other site 701177000655 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 701177000656 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 701177000657 Ligand Binding Site [chemical binding]; other site 701177000658 TilS substrate binding domain; Region: TilS; pfam09179 701177000659 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 701177000660 Rho-binding antiterminator; Provisional; Region: PRK11625 701177000661 hypothetical protein; Provisional; Region: PRK04964 701177000662 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 701177000663 hypothetical protein; Provisional; Region: PRK09256 701177000664 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 701177000665 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 701177000666 NlpE N-terminal domain; Region: NlpE; pfam04170 701177000667 hypothetical protein; Provisional; Region: PRK11479 701177000668 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 701177000669 prolyl-tRNA synthetase; Provisional; Region: PRK09194 701177000670 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 701177000671 dimer interface [polypeptide binding]; other site 701177000672 motif 1; other site 701177000673 active site 701177000674 motif 2; other site 701177000675 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 701177000676 putative deacylase active site [active] 701177000677 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 701177000678 active site 701177000679 motif 3; other site 701177000680 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 701177000681 anticodon binding site; other site 701177000682 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 701177000683 homodimer interaction site [polypeptide binding]; other site 701177000684 cofactor binding site; other site 701177000685 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 701177000686 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 701177000687 lipoprotein, YaeC family; Region: TIGR00363 701177000688 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 701177000689 dimer interface [polypeptide binding]; other site 701177000690 conserved gate region; other site 701177000691 ABC-ATPase subunit interface; other site 701177000692 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 701177000693 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 701177000694 Walker A/P-loop; other site 701177000695 ATP binding site [chemical binding]; other site 701177000696 Q-loop/lid; other site 701177000697 ABC transporter signature motif; other site 701177000698 Walker B; other site 701177000699 D-loop; other site 701177000700 H-loop/switch region; other site 701177000701 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 701177000702 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 701177000703 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 701177000704 active site 701177000705 motif I; other site 701177000706 motif II; other site 701177000707 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 701177000708 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 701177000709 active site 701177000710 catalytic tetrad [active] 701177000711 Transcriptional regulator [Transcription]; Region: LysR; COG0583 701177000712 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 701177000713 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 701177000714 putative effector binding pocket; other site 701177000715 dimerization interface [polypeptide binding]; other site 701177000716 hypothetical protein; Provisional; Region: PRK05421 701177000717 putative catalytic site [active] 701177000718 putative metal binding site [ion binding]; other site 701177000719 putative phosphate binding site [ion binding]; other site 701177000720 putative catalytic site [active] 701177000721 putative phosphate binding site [ion binding]; other site 701177000722 putative metal binding site [ion binding]; other site 701177000723 Methyltransferase domain; Region: Methyltransf_31; pfam13847 701177000724 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 701177000725 S-adenosylmethionine binding site [chemical binding]; other site 701177000726 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 701177000727 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 701177000728 N-acetyl-D-glucosamine binding site [chemical binding]; other site 701177000729 catalytic residue [active] 701177000730 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 701177000731 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 701177000732 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 701177000733 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 701177000734 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 701177000735 RNA/DNA hybrid binding site [nucleotide binding]; other site 701177000736 active site 701177000737 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 701177000738 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 701177000739 active site 701177000740 catalytic site [active] 701177000741 substrate binding site [chemical binding]; other site 701177000742 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 701177000743 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 701177000744 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 701177000745 ImpA domain protein; Region: DUF3702; pfam12486 701177000746 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 701177000747 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 701177000748 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 701177000749 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 701177000750 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 701177000751 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 701177000752 type VI secretion-associated protein, VC_A0118 family; Region: VI_minor_1; TIGR03360 701177000753 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 701177000754 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 701177000755 Walker A motif; other site 701177000756 ATP binding site [chemical binding]; other site 701177000757 Walker B motif; other site 701177000758 arginine finger; other site 701177000759 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 701177000760 Walker A motif; other site 701177000761 ATP binding site [chemical binding]; other site 701177000762 Walker B motif; other site 701177000763 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 701177000764 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 701177000765 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 701177000766 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 701177000767 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3521 701177000768 Predicted component of the type VI protein secretion system, contains a FHA domain [Intracellular trafficking, secretion, and vesicular transport; Signal transduction mechanisms]; Region: COG3456 701177000769 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3520 701177000770 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 701177000771 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 701177000772 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 701177000773 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 701177000774 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 701177000775 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 701177000776 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 701177000777 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 701177000778 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 701177000779 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 701177000780 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 701177000781 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 701177000782 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 701177000783 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 701177000784 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 701177000785 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 701177000786 Transposase [DNA replication, recombination, and repair]; Region: COG5433 701177000787 Transposase [DNA replication, recombination, and repair]; Region: COG5433 701177000788 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 701177000789 Erythromycin esterase; Region: Erythro_esteras; cl17110 701177000790 RHS protein; Region: RHS; pfam03527 701177000791 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 701177000792 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 701177000793 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 701177000794 Transposase [DNA replication, recombination, and repair]; Region: COG5433 701177000795 Transposase [DNA replication, recombination, and repair]; Region: COG5433 701177000796 C-N hydrolase family amidase; Provisional; Region: PRK10438 701177000797 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 701177000798 putative active site [active] 701177000799 catalytic triad [active] 701177000800 dimer interface [polypeptide binding]; other site 701177000801 multimer interface [polypeptide binding]; other site 701177000802 C-lysozyme inhibitor; Provisional; Region: PRK09993 701177000803 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 701177000804 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 701177000805 active site 701177000806 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 701177000807 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 701177000808 dimer interface [polypeptide binding]; other site 701177000809 active site 701177000810 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 701177000811 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 701177000812 putative active site [active] 701177000813 putative dimer interface [polypeptide binding]; other site 701177000814 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 701177000815 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 701177000816 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041 701177000817 RelB antitoxin; Region: RelB; cl01171 701177000818 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 701177000819 NlpC/P60 family; Region: NLPC_P60; pfam00877 701177000820 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 701177000821 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298 701177000822 FHIPEP family; Region: FHIPEP; pfam00771 701177000823 hypothetical protein; Validated; Region: PRK06778 701177000824 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 701177000825 ligand binding site [chemical binding]; other site 701177000826 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 701177000827 active site 701177000828 DNA polymerase IV; Validated; Region: PRK02406 701177000829 DNA binding site [nucleotide binding] 701177000830 putative antitoxin of the YafO-YafN toxin-antitoxin system; Provisional; Region: PRK09778 701177000831 putative toxin YafO; Provisional; Region: PRK09885 701177000832 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 701177000833 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 701177000834 Coenzyme A binding pocket [chemical binding]; other site 701177000835 Uncharacterized protein family UPF0027; Region: UPF0027; cl17455 701177000836 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 701177000837 peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179 701177000838 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 701177000839 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 701177000840 metal binding site [ion binding]; metal-binding site 701177000841 dimer interface [polypeptide binding]; other site 701177000842 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 701177000843 active site 701177000844 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 701177000845 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 701177000846 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 701177000847 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 701177000848 trimer interface [polypeptide binding]; other site 701177000849 eyelet of channel; other site 701177000850 gamma-glutamyl kinase; Provisional; Region: PRK05429 701177000851 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 701177000852 nucleotide binding site [chemical binding]; other site 701177000853 homotetrameric interface [polypeptide binding]; other site 701177000854 putative phosphate binding site [ion binding]; other site 701177000855 putative allosteric binding site; other site 701177000856 PUA domain; Region: PUA; pfam01472 701177000857 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 701177000858 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 701177000859 putative catalytic cysteine [active] 701177000860 integrase; Provisional; Region: int; PHA02601 701177000861 P22-like integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial and phage integrases, including those similar to phage P22-like integrases, DLP12 and APSE-1; Region: INT_P22_C; cd01192 701177000862 Int/Topo IB signature motif; other site 701177000863 Protein of unknown function (DUF550); Region: DUF550; pfam04447 701177000864 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 701177000865 DksA-like zinc finger domain containing protein; Region: PHA00080 701177000866 Protein of unknown function (DUF1382); Region: DUF1382; pfam07131 701177000867 Protein of unknown function (DUF1317); Region: DUF1317; pfam07026 701177000868 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 701177000869 phage recombination protein Bet; Region: bet_lambda; TIGR01913 701177000870 Host-nuclease inhibitor protein Gam; Region: Gam; pfam06064 701177000871 Lambda Phage CIII; Region: Lambda_CIII; pfam02061 701177000872 Antirestriction protein Ral; Region: Ral; pfam11058 701177000873 Superinfection exclusion protein B; Region: SieB; pfam14163 701177000874 36-mer N-terminal peptide of the N protein (N36); Region: N36; pfam11438 701177000875 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 701177000876 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 701177000877 non-specific DNA binding site [nucleotide binding]; other site 701177000878 salt bridge; other site 701177000879 sequence-specific DNA binding site [nucleotide binding]; other site 701177000880 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 701177000881 Catalytic site [active] 701177000882 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 701177000883 non-specific DNA binding site [nucleotide binding]; other site 701177000884 salt bridge; other site 701177000885 sequence-specific DNA binding site [nucleotide binding]; other site 701177000886 Bacteriophage CII protein; Region: Phage_CII; pfam05269 701177000887 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 701177000888 Replication protein P; Region: Phage_lambda_P; pfam06992 701177000889 NinB protein; Region: NinB; pfam05772 701177000890 phage N-6-adenine-methyltransferase; Region: phage_N6A_met; TIGR01712 701177000891 NINE Protein; Region: NinE; pfam05322 701177000892 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 701177000893 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 701177000894 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 701177000895 active site 701177000896 metal binding site [ion binding]; metal-binding site 701177000897 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 701177000898 Protein of unknown function (DUF3927); Region: DUF3927; pfam13064 701177000899 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 701177000900 Domain of unknown function (DUF303); Region: DUF303; pfam03629 701177000901 Lysis protein S; Region: Lysis_S; pfam04971 701177000902 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 701177000903 catalytic residues [active] 701177000904 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 701177000905 PerC transcriptional activator; Region: PerC; pfam06069 701177000906 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 701177000907 Phage DNA packaging protein, Nu1 subunit of terminase [DNA replication, recombination, and repair]; Region: COG4220 701177000908 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 701177000909 gpW; Region: gpW; pfam02831 701177000910 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 701177000911 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 701177000912 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 701177000913 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 701177000914 tandem repeat interface [polypeptide binding]; other site 701177000915 oligomer interface [polypeptide binding]; other site 701177000916 active site residues [active] 701177000917 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 701177000918 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 701177000919 DNA packaging protein FI; Region: Packaging_FI; pfam14000 701177000920 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 701177000921 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 701177000922 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 701177000923 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 701177000924 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 701177000925 phage minor tail protein G; Region: phage_lambda_G; TIGR01674 701177000926 Minor tail protein T; Region: Phage_tail_T; pfam06223 701177000927 Phage-related minor tail protein [Function unknown]; Region: COG5281 701177000928 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 701177000929 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 701177000930 Phage-related protein [Function unknown]; Region: COG4718 701177000931 Phage-related protein [Function unknown]; Region: gp18; COG4672 701177000932 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 701177000933 MPN+ (JAMM) motif; other site 701177000934 Zinc-binding site [ion binding]; other site 701177000935 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 701177000936 NlpC/P60 family; Region: NLPC_P60; cl17555 701177000937 Phage-related protein, tail component [Function unknown]; Region: COG4723 701177000938 Phage-related protein, tail component [Function unknown]; Region: COG4733 701177000939 Putative phage tail protein; Region: Phage-tail_3; pfam13550 701177000940 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 701177000941 Interdomain contacts; other site 701177000942 Cytokine receptor motif; other site 701177000943 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 701177000944 Fibronectin type III protein; Region: DUF3672; pfam12421 701177000945 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 701177000946 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 701177000947 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 701177000948 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 701177000949 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 701177000950 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 701177000951 IpaB/EvcA family; Region: IpaB_EvcA; pfam03278 701177000952 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 701177000953 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 701177000954 non-LEE encoded effector protein NleB; Provisional; Region: PRK15382 701177000955 type III secretion system protein; Provisional; Region: PRK15384; cl14665 701177000956 integrase; Provisional; Region: PRK09692 701177000957 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 701177000958 active site 701177000959 Int/Topo IB signature motif; other site 701177000960 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 701177000961 Phage polarity suppression protein (Psu); Region: Psu; pfam07455 701177000962 Phage polarity suppression protein (Psu); Region: Psu; pfam07455 701177000963 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 701177000964 Ash protein family; Region: Phage_ASH; pfam10554 701177000965 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 701177000966 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 701177000967 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 701177000968 active site 701177000969 metal binding site [ion binding]; metal-binding site 701177000970 interdomain interaction site; other site 701177000971 D5 N terminal like; Region: D5_N; smart00885 701177000972 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 701177000973 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 701177000974 Transcriptional regulator [Transcription]; Region: LysR; COG0583 701177000975 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 701177000976 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 701177000977 putative effector binding pocket; other site 701177000978 putative dimerization interface [polypeptide binding]; other site 701177000979 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 701177000980 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 701177000981 NAD(P) binding site [chemical binding]; other site 701177000982 active site 701177000983 Transcriptional regulator [Transcription]; Region: LysR; COG0583 701177000984 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 701177000985 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 701177000986 putative effector binding pocket; other site 701177000987 putative dimerization interface [polypeptide binding]; other site 701177000988 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 701177000989 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 701177000990 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177000991 putative substrate translocation pore; other site 701177000992 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 701177000993 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 701177000994 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 701177000995 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 701177000996 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 701177000997 aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433 701177000998 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 701177000999 catalytic loop [active] 701177001000 iron binding site [ion binding]; other site 701177001001 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 701177001002 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 701177001003 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 701177001004 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 701177001005 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 701177001006 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 701177001007 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 701177001008 DNA binding residues [nucleotide binding] 701177001009 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 701177001010 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 701177001011 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 701177001012 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 701177001013 putative active site [active] 701177001014 putative FMN binding site [chemical binding]; other site 701177001015 putative substrate binding site [chemical binding]; other site 701177001016 putative catalytic residue [active] 701177001017 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 701177001018 Transcriptional regulator [Transcription]; Region: LysR; COG0583 701177001019 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 701177001020 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 701177001021 putative effector binding pocket; other site 701177001022 putative dimerization interface [polypeptide binding]; other site 701177001023 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 701177001024 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 701177001025 active site 701177001026 catalytic tetrad [active] 701177001027 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 701177001028 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 701177001029 Filamin/ABP280 repeat; Region: Filamin; pfam00630 701177001030 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 701177001031 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 701177001032 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 701177001033 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 701177001034 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 701177001035 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 701177001036 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 701177001037 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 701177001038 active site 701177001039 catalytic tetrad [active] 701177001040 Predicted membrane protein [Function unknown]; Region: COG3059 701177001041 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 701177001042 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010 701177001043 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 701177001044 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 701177001045 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 701177001046 Cupin; Region: Cupin_6; pfam12852 701177001047 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 701177001048 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 701177001049 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 701177001050 Cysteine-rich domain; Region: CCG; pfam02754 701177001051 Cysteine-rich domain; Region: CCG; pfam02754 701177001052 iron-sulfur cluster-binding protein; Region: TIGR00273 701177001053 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 701177001054 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 701177001055 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 701177001056 Uncharacterized conserved protein [Function unknown]; Region: COG1556 701177001057 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 701177001058 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 701177001059 Autotransporter beta-domain; Region: Autotransporter; pfam03797 701177001060 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 701177001061 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 701177001062 DNA binding residues [nucleotide binding] 701177001063 dimerization interface [polypeptide binding]; other site 701177001064 choline dehydrogenase; Validated; Region: PRK02106 701177001065 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 701177001066 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 701177001067 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 701177001068 tetrameric interface [polypeptide binding]; other site 701177001069 NAD binding site [chemical binding]; other site 701177001070 catalytic residues [active] 701177001071 transcriptional regulator BetI; Validated; Region: PRK00767 701177001072 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 701177001073 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 701177001074 choline transport protein BetT; Provisional; Region: PRK09928 701177001075 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 701177001076 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 701177001077 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 701177001078 Autotransporter beta-domain; Region: Autotransporter; pfam03797 701177001079 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 701177001080 DNA binding residues [nucleotide binding] 701177001081 dimerization interface [polypeptide binding]; other site 701177001082 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 701177001083 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 701177001084 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 701177001085 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 701177001086 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 701177001087 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 701177001088 CoA binding domain; Region: CoA_binding; pfam02629 701177001089 CoA-ligase; Region: Ligase_CoA; pfam00549 701177001090 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 701177001091 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 701177001092 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 701177001093 putative substrate binding site [chemical binding]; other site 701177001094 nucleotide binding site [chemical binding]; other site 701177001095 nucleotide binding site [chemical binding]; other site 701177001096 homodimer interface [polypeptide binding]; other site 701177001097 putative deaminase; Validated; Region: PRK06846 701177001098 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 701177001099 active site 701177001100 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 701177001101 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 701177001102 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 701177001103 ligand binding site [chemical binding]; other site 701177001104 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 701177001105 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 701177001106 Walker A/P-loop; other site 701177001107 ATP binding site [chemical binding]; other site 701177001108 Q-loop/lid; other site 701177001109 ABC transporter signature motif; other site 701177001110 Walker B; other site 701177001111 D-loop; other site 701177001112 H-loop/switch region; other site 701177001113 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 701177001114 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 701177001115 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 701177001116 TM-ABC transporter signature motif; other site 701177001117 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 701177001118 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 701177001119 TM-ABC transporter signature motif; other site 701177001120 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 701177001121 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 701177001122 putative NAD(P) binding site [chemical binding]; other site 701177001123 putative substrate binding site [chemical binding]; other site 701177001124 catalytic Zn binding site [ion binding]; other site 701177001125 structural Zn binding site [ion binding]; other site 701177001126 dimer interface [polypeptide binding]; other site 701177001127 The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949 701177001128 hypothetical protein; Provisional; Region: PRK09929 701177001129 propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424 701177001130 Propionate catabolism activator; Region: PrpR_N; pfam06506 701177001131 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 701177001132 Walker A motif; other site 701177001133 ATP binding site [chemical binding]; other site 701177001134 Walker B motif; other site 701177001135 arginine finger; other site 701177001136 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 701177001137 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 701177001138 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 701177001139 tetramer interface [polypeptide binding]; other site 701177001140 active site 701177001141 Mg2+/Mn2+ binding site [ion binding]; other site 701177001142 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 701177001143 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 701177001144 dimer interface [polypeptide binding]; other site 701177001145 active site 701177001146 citrylCoA binding site [chemical binding]; other site 701177001147 oxalacetate/citrate binding site [chemical binding]; other site 701177001148 coenzyme A binding site [chemical binding]; other site 701177001149 catalytic triad [active] 701177001150 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 701177001151 2-methylcitrate dehydratase; Region: prpD; TIGR02330 701177001152 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 701177001153 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 701177001154 acyl-activating enzyme (AAE) consensus motif; other site 701177001155 putative AMP binding site [chemical binding]; other site 701177001156 putative active site [active] 701177001157 putative CoA binding site [chemical binding]; other site 701177001158 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 701177001159 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 701177001160 Na binding site [ion binding]; other site 701177001161 putative substrate binding site [chemical binding]; other site 701177001162 cytosine deaminase; Provisional; Region: PRK09230 701177001163 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 701177001164 active site 701177001165 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 701177001166 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 701177001167 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425 701177001168 dimerization interface [polypeptide binding]; other site 701177001169 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 701177001170 active site clefts [active] 701177001171 zinc binding site [ion binding]; other site 701177001172 dimer interface [polypeptide binding]; other site 701177001173 Cyanate lyase [Inorganic ion transport and metabolism]; Region: CynS; COG1513 701177001174 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 701177001175 oligomer interface [polypeptide binding]; other site 701177001176 active site 701177001177 putative cyanate transporter; Provisional; Region: cynX; PRK09705 701177001178 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177001179 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 701177001180 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 701177001181 active site 701177001182 substrate binding site [chemical binding]; other site 701177001183 trimer interface [polypeptide binding]; other site 701177001184 CoA binding site [chemical binding]; other site 701177001185 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 701177001186 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177001187 putative substrate translocation pore; other site 701177001188 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 701177001189 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 701177001190 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 701177001191 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 701177001192 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 701177001193 lac repressor; Reviewed; Region: lacI; PRK09526 701177001194 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 701177001195 DNA binding site [nucleotide binding] 701177001196 domain linker motif; other site 701177001197 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 701177001198 ligand binding site [chemical binding]; other site 701177001199 dimerization interface (open form) [polypeptide binding]; other site 701177001200 dimerization interface (closed form) [polypeptide binding]; other site 701177001201 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 701177001202 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 701177001203 conserved cys residue [active] 701177001204 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 701177001205 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 701177001206 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 701177001207 DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834 701177001208 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 701177001209 Bacterial transcriptional regulator; Region: IclR; pfam01614 701177001210 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 701177001211 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 701177001212 Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB), which catalyzes the oxidization and subsequent ring-opening of 2,3-dihydroxyphenylpropionate; Region: MhpB_like; cd07365 701177001213 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 701177001214 putative active site [active] 701177001215 Fe(II) binding site [ion binding]; other site 701177001216 putative dimer interface [polypeptide binding]; other site 701177001217 putative tetramer interface [polypeptide binding]; other site 701177001218 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 701177001219 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 701177001220 nucleophilic elbow; other site 701177001221 catalytic triad; other site 701177001222 2-keto-4-pentenoate hydratase; Provisional; Region: mhpD; PRK11342 701177001223 acetaldehyde dehydrogenase; Validated; Region: PRK08300 701177001224 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 701177001225 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 701177001226 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 701177001227 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 701177001228 active site 701177001229 catalytic residues [active] 701177001230 metal binding site [ion binding]; metal-binding site 701177001231 DmpG-like communication domain; Region: DmpG_comm; pfam07836 701177001232 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 701177001233 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177001234 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177001235 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 701177001236 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 701177001237 S-formylglutathione hydrolase; Region: PLN02442 701177001238 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 701177001239 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 701177001240 substrate binding site [chemical binding]; other site 701177001241 catalytic Zn binding site [ion binding]; other site 701177001242 NAD binding site [chemical binding]; other site 701177001243 structural Zn binding site [ion binding]; other site 701177001244 dimer interface [polypeptide binding]; other site 701177001245 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 701177001246 putative metal binding site [ion binding]; other site 701177001247 putative homodimer interface [polypeptide binding]; other site 701177001248 putative homotetramer interface [polypeptide binding]; other site 701177001249 putative homodimer-homodimer interface [polypeptide binding]; other site 701177001250 putative allosteric switch controlling residues; other site 701177001251 ferric transporter ATP-binding subunit; Provisional; Region: fbpC; PRK11432 701177001252 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 701177001253 Walker A/P-loop; other site 701177001254 ATP binding site [chemical binding]; other site 701177001255 Q-loop/lid; other site 701177001256 ABC transporter signature motif; other site 701177001257 Walker B; other site 701177001258 D-loop; other site 701177001259 H-loop/switch region; other site 701177001260 TOBE domain; Region: TOBE_2; pfam08402 701177001261 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 701177001262 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 701177001263 dimer interface [polypeptide binding]; other site 701177001264 conserved gate region; other site 701177001265 putative PBP binding loops; other site 701177001266 ABC-ATPase subunit interface; other site 701177001267 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 701177001268 dimer interface [polypeptide binding]; other site 701177001269 conserved gate region; other site 701177001270 putative PBP binding loops; other site 701177001271 ABC-ATPase subunit interface; other site 701177001272 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 701177001273 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 701177001274 regulatory protein UhpC; Provisional; Region: PRK11663 701177001275 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177001276 putative substrate translocation pore; other site 701177001277 Signal transduction histidine kinase, glucose-6-phosphate specific [Signal transduction mechanisms]; Region: UhpB; COG3851 701177001278 MASE1; Region: MASE1; pfam05231 701177001279 Histidine kinase; Region: HisKA_3; pfam07730 701177001280 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 701177001281 ATP binding site [chemical binding]; other site 701177001282 Mg2+ binding site [ion binding]; other site 701177001283 G-X-G motif; other site 701177001284 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 701177001285 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 701177001286 active site 701177001287 phosphorylation site [posttranslational modification] 701177001288 intermolecular recognition site; other site 701177001289 dimerization interface [polypeptide binding]; other site 701177001290 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 701177001291 DNA binding residues [nucleotide binding] 701177001292 dimerization interface [polypeptide binding]; other site 701177001293 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 701177001294 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 701177001295 substrate binding pocket [chemical binding]; other site 701177001296 membrane-bound complex binding site; other site 701177001297 hinge residues; other site 701177001298 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 701177001299 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 701177001300 Walker A/P-loop; other site 701177001301 ATP binding site [chemical binding]; other site 701177001302 Q-loop/lid; other site 701177001303 ABC transporter signature motif; other site 701177001304 Walker B; other site 701177001305 D-loop; other site 701177001306 H-loop/switch region; other site 701177001307 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 701177001308 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 701177001309 dimer interface [polypeptide binding]; other site 701177001310 conserved gate region; other site 701177001311 putative PBP binding loops; other site 701177001312 ABC-ATPase subunit interface; other site 701177001313 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 701177001314 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 701177001315 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 701177001316 dimer interface [polypeptide binding]; other site 701177001317 active site 701177001318 Schiff base residues; other site 701177001319 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 701177001320 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 701177001321 Autotransporter beta-domain; Region: Autotransporter; pfam03797 701177001322 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 701177001323 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 701177001324 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 701177001325 microcin B17 transporter; Reviewed; Region: PRK11098 701177001326 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 701177001327 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 701177001328 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 701177001329 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 701177001330 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 701177001331 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 701177001332 anti-RssB factor; Provisional; Region: PRK10244 701177001333 alkaline phosphatase; Provisional; Region: PRK10518 701177001334 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 701177001335 dimer interface [polypeptide binding]; other site 701177001336 active site 701177001337 hypothetical protein; Provisional; Region: PRK11505 701177001338 psiF repeat; Region: PsiF_repeat; pfam07769 701177001339 psiF repeat; Region: PsiF_repeat; pfam07769 701177001340 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 701177001341 MASE2 domain; Region: MASE2; pfam05230 701177001342 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 701177001343 metal binding site [ion binding]; metal-binding site 701177001344 active site 701177001345 I-site; other site 701177001346 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 701177001347 pyrroline-5-carboxylate reductase; Region: PLN02688 701177001348 hypothetical protein; Validated; Region: PRK00124 701177001349 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 701177001350 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 701177001351 ADP binding site [chemical binding]; other site 701177001352 magnesium binding site [ion binding]; other site 701177001353 putative shikimate binding site; other site 701177001354 hypothetical protein; Provisional; Region: PRK10380 701177001355 hypothetical protein; Provisional; Region: PRK10481 701177001356 hypothetical protein; Provisional; Region: PRK10579 701177001357 Protein of unknown function (DUF2773); Region: DUF2773; pfam10971 701177001358 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 701177001359 DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974 701177001360 fructokinase; Reviewed; Region: PRK09557 701177001361 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 701177001362 nucleotide binding site [chemical binding]; other site 701177001363 MFS transport protein AraJ; Provisional; Region: PRK10091 701177001364 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177001365 putative substrate translocation pore; other site 701177001366 exonuclease subunit SbcC; Provisional; Region: PRK10246 701177001367 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 701177001368 Walker A/P-loop; other site 701177001369 ATP binding site [chemical binding]; other site 701177001370 Q-loop/lid; other site 701177001371 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 701177001372 ABC transporter signature motif; other site 701177001373 Walker B; other site 701177001374 D-loop; other site 701177001375 H-loop/switch region; other site 701177001376 exonuclease subunit SbcD; Provisional; Region: PRK10966 701177001377 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 701177001378 active site 701177001379 metal binding site [ion binding]; metal-binding site 701177001380 DNA binding site [nucleotide binding] 701177001381 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 701177001382 transcriptional regulator PhoB; Provisional; Region: PRK10161 701177001383 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 701177001384 active site 701177001385 phosphorylation site [posttranslational modification] 701177001386 intermolecular recognition site; other site 701177001387 dimerization interface [polypeptide binding]; other site 701177001388 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 701177001389 DNA binding site [nucleotide binding] 701177001390 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 701177001391 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 701177001392 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 701177001393 putative active site [active] 701177001394 heme pocket [chemical binding]; other site 701177001395 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 701177001396 dimer interface [polypeptide binding]; other site 701177001397 phosphorylation site [posttranslational modification] 701177001398 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 701177001399 ATP binding site [chemical binding]; other site 701177001400 Mg2+ binding site [ion binding]; other site 701177001401 G-X-G motif; other site 701177001402 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 701177001403 putative proline-specific permease; Provisional; Region: proY; PRK10580 701177001404 Spore germination protein; Region: Spore_permease; cl17796 701177001405 maltodextrin glucosidase; Provisional; Region: PRK10785 701177001406 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 701177001407 homodimer interface [polypeptide binding]; other site 701177001408 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 701177001409 active site 701177001410 homodimer interface [polypeptide binding]; other site 701177001411 catalytic site [active] 701177001412 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 701177001413 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 701177001414 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 701177001415 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 701177001416 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 701177001417 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 701177001418 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 701177001419 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 701177001420 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 701177001421 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 701177001422 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 701177001423 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 701177001424 Protein export membrane protein; Region: SecD_SecF; pfam02355 701177001425 Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693 701177001426 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 701177001427 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 701177001428 active site 701177001429 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 701177001430 hypothetical protein; Provisional; Region: PRK11530 701177001431 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 701177001432 ATP cone domain; Region: ATP-cone; pfam03477 701177001433 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 701177001434 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 701177001435 catalytic motif [active] 701177001436 Zn binding site [ion binding]; other site 701177001437 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 701177001438 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 701177001439 homopentamer interface [polypeptide binding]; other site 701177001440 active site 701177001441 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 701177001442 putative RNA binding site [nucleotide binding]; other site 701177001443 thiamine monophosphate kinase; Provisional; Region: PRK05731 701177001444 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 701177001445 ATP binding site [chemical binding]; other site 701177001446 dimerization interface [polypeptide binding]; other site 701177001447 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 701177001448 tetramer interfaces [polypeptide binding]; other site 701177001449 binuclear metal-binding site [ion binding]; other site 701177001450 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 701177001451 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 701177001452 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 701177001453 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 701177001454 active site 701177001455 catalytic tetrad [active] 701177001456 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 701177001457 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 701177001458 TPP-binding site; other site 701177001459 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 701177001460 PYR/PP interface [polypeptide binding]; other site 701177001461 dimer interface [polypeptide binding]; other site 701177001462 TPP binding site [chemical binding]; other site 701177001463 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 701177001464 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 701177001465 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 701177001466 substrate binding pocket [chemical binding]; other site 701177001467 chain length determination region; other site 701177001468 substrate-Mg2+ binding site; other site 701177001469 catalytic residues [active] 701177001470 aspartate-rich region 1; other site 701177001471 active site lid residues [active] 701177001472 aspartate-rich region 2; other site 701177001473 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 701177001474 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 701177001475 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 701177001476 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 701177001477 Ligand Binding Site [chemical binding]; other site 701177001478 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 701177001479 active site residue [active] 701177001480 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 701177001481 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 701177001482 conserved cys residue [active] 701177001483 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 701177001484 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 701177001485 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 701177001486 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 701177001487 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 701177001488 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177001489 Major Facilitator Superfamily; Region: MFS_1; pfam07690 701177001490 putative substrate translocation pore; other site 701177001491 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 701177001492 UbiA prenyltransferase family; Region: UbiA; pfam01040 701177001493 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 701177001494 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 701177001495 Subunit I/III interface [polypeptide binding]; other site 701177001496 Subunit III/IV interface [polypeptide binding]; other site 701177001497 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 701177001498 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 701177001499 D-pathway; other site 701177001500 Putative ubiquinol binding site [chemical binding]; other site 701177001501 Low-spin heme (heme b) binding site [chemical binding]; other site 701177001502 Putative water exit pathway; other site 701177001503 Binuclear center (heme o3/CuB) [ion binding]; other site 701177001504 K-pathway; other site 701177001505 Putative proton exit pathway; other site 701177001506 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 701177001507 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 701177001508 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 701177001509 muropeptide transporter; Reviewed; Region: ampG; PRK11902 701177001510 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177001511 putative substrate translocation pore; other site 701177001512 hypothetical protein; Provisional; Region: PRK11627 701177001513 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 701177001514 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 701177001515 transcriptional regulator BolA; Provisional; Region: PRK11628 701177001516 trigger factor; Provisional; Region: tig; PRK01490 701177001517 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 701177001518 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 701177001519 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 701177001520 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 701177001521 oligomer interface [polypeptide binding]; other site 701177001522 active site residues [active] 701177001523 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 701177001524 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 701177001525 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 701177001526 Walker A motif; other site 701177001527 ATP binding site [chemical binding]; other site 701177001528 Walker B motif; other site 701177001529 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 701177001530 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 701177001531 Found in ATP-dependent protease La (LON); Region: LON; smart00464 701177001532 Found in ATP-dependent protease La (LON); Region: LON; smart00464 701177001533 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 701177001534 Walker A motif; other site 701177001535 ATP binding site [chemical binding]; other site 701177001536 Walker B motif; other site 701177001537 arginine finger; other site 701177001538 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 701177001539 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 701177001540 IHF dimer interface [polypeptide binding]; other site 701177001541 IHF - DNA interface [nucleotide binding]; other site 701177001542 periplasmic folding chaperone; Provisional; Region: PRK10788 701177001543 SurA N-terminal domain; Region: SurA_N_3; cl07813 701177001544 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 701177001545 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 701177001546 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 701177001547 active site 701177001548 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 701177001549 Ligand Binding Site [chemical binding]; other site 701177001550 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 701177001551 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 701177001552 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 701177001553 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 701177001554 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 701177001555 active site 701177001556 motif I; other site 701177001557 motif II; other site 701177001558 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 701177001559 dimerization interface [polypeptide binding]; other site 701177001560 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 701177001561 putative DNA binding site [nucleotide binding]; other site 701177001562 putative Zn2+ binding site [ion binding]; other site 701177001563 AsnC family; Region: AsnC_trans_reg; pfam01037 701177001564 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 701177001565 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 701177001566 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 701177001567 Walker A/P-loop; other site 701177001568 ATP binding site [chemical binding]; other site 701177001569 Q-loop/lid; other site 701177001570 ABC transporter signature motif; other site 701177001571 Walker B; other site 701177001572 D-loop; other site 701177001573 H-loop/switch region; other site 701177001574 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 701177001575 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 701177001576 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 701177001577 Walker A/P-loop; other site 701177001578 ATP binding site [chemical binding]; other site 701177001579 Q-loop/lid; other site 701177001580 ABC transporter signature motif; other site 701177001581 Walker B; other site 701177001582 D-loop; other site 701177001583 H-loop/switch region; other site 701177001584 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 701177001585 Nitrogen regulatory protein P-II; Region: P-II; smart00938 701177001586 ammonium transporter; Provisional; Region: PRK10666 701177001587 acyl-CoA thioesterase II; Provisional; Region: PRK10526 701177001588 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 701177001589 active site 701177001590 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 701177001591 catalytic triad [active] 701177001592 dimer interface [polypeptide binding]; other site 701177001593 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 701177001594 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 701177001595 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 701177001596 DNA binding site [nucleotide binding] 701177001597 active site 701177001598 Uncharacterized conserved protein [Function unknown]; Region: COG5507 701177001599 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 701177001600 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 701177001601 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 701177001602 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 701177001603 maltose O-acetyltransferase; Provisional; Region: PRK10092 701177001604 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 701177001605 active site 701177001606 substrate binding site [chemical binding]; other site 701177001607 trimer interface [polypeptide binding]; other site 701177001608 CoA binding site [chemical binding]; other site 701177001609 gene expression modulator; Provisional; Region: PRK10945 701177001610 Biofilm formation regulator YbaJ; Region: YbaJ; pfam10757 701177001611 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 701177001612 Protein export membrane protein; Region: SecD_SecF; cl14618 701177001613 Protein export membrane protein; Region: SecD_SecF; cl14618 701177001614 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 701177001615 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 701177001616 HlyD family secretion protein; Region: HlyD_3; pfam13437 701177001617 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 701177001618 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 701177001619 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 701177001620 hypothetical protein; Provisional; Region: PRK11281 701177001621 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 701177001622 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 701177001623 Mechanosensitive ion channel; Region: MS_channel; pfam00924 701177001624 hypothetical protein; Provisional; Region: PRK11038 701177001625 primosomal replication protein N''; Provisional; Region: PRK10093 701177001626 hypothetical protein; Provisional; Region: PRK10527 701177001627 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 701177001628 active site 701177001629 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 701177001630 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 701177001631 Walker A motif; other site 701177001632 ATP binding site [chemical binding]; other site 701177001633 Walker B motif; other site 701177001634 DNA polymerase III subunit delta'; Validated; Region: PRK08485 701177001635 arginine finger; other site 701177001636 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 701177001637 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 701177001638 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 701177001639 hypothetical protein; Validated; Region: PRK00153 701177001640 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecR; COG0353 701177001641 RecR protein; Region: RecR; pfam02132 701177001642 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 701177001643 putative active site [active] 701177001644 putative metal-binding site [ion binding]; other site 701177001645 tetramer interface [polypeptide binding]; other site 701177001646 heat shock protein 90; Provisional; Region: PRK05218 701177001647 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 701177001648 ATP binding site [chemical binding]; other site 701177001649 Mg2+ binding site [ion binding]; other site 701177001650 G-X-G motif; other site 701177001651 adenylate kinase; Reviewed; Region: adk; PRK00279 701177001652 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 701177001653 AMP-binding site [chemical binding]; other site 701177001654 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 701177001655 ferrochelatase; Region: hemH; TIGR00109 701177001656 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 701177001657 C-terminal domain interface [polypeptide binding]; other site 701177001658 active site 701177001659 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 701177001660 active site 701177001661 N-terminal domain interface [polypeptide binding]; other site 701177001662 acetyl esterase; Provisional; Region: PRK10162 701177001663 inosine/guanosine kinase; Provisional; Region: PRK15074 701177001664 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 701177001665 putative cation:proton antiport protein; Provisional; Region: PRK10669 701177001666 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 701177001667 TrkA-N domain; Region: TrkA_N; pfam02254 701177001668 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177001669 Major Facilitator Superfamily; Region: MFS_1; pfam07690 701177001670 putative substrate translocation pore; other site 701177001671 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 701177001672 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 701177001673 active site 701177001674 metal binding site [ion binding]; metal-binding site 701177001675 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 701177001676 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 701177001677 putative deacylase active site [active] 701177001678 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 701177001679 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 701177001680 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 701177001681 non-specific DNA binding site [nucleotide binding]; other site 701177001682 salt bridge; other site 701177001683 sequence-specific DNA binding site [nucleotide binding]; other site 701177001684 copper exporting ATPase; Provisional; Region: copA; PRK10671 701177001685 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 701177001686 metal-binding site [ion binding] 701177001687 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 701177001688 metal-binding site [ion binding] 701177001689 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 701177001690 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 701177001691 motif II; other site 701177001692 glutaminase; Reviewed; Region: PRK12356 701177001693 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 701177001694 amino acid transporter; Region: 2A0306; TIGR00909 701177001695 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 701177001696 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 701177001697 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 701177001698 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 701177001699 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 701177001700 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 701177001701 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 701177001702 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 701177001703 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 701177001704 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 701177001705 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 701177001706 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 701177001707 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 701177001708 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 701177001709 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 701177001710 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 701177001711 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 701177001712 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 701177001713 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 701177001714 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 701177001715 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 701177001716 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 701177001717 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 701177001718 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 701177001719 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 701177001720 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 701177001721 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 701177001722 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 701177001723 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 701177001724 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 701177001725 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 701177001726 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 701177001727 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 701177001728 Family description; Region: VCBS; pfam13517 701177001729 Family description; Region: VCBS; pfam13517 701177001730 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 701177001731 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 701177001732 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 701177001733 putative active site [active] 701177001734 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 701177001735 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 701177001736 Walker A/P-loop; other site 701177001737 ATP binding site [chemical binding]; other site 701177001738 Q-loop/lid; other site 701177001739 ABC transporter signature motif; other site 701177001740 Walker B; other site 701177001741 D-loop; other site 701177001742 H-loop/switch region; other site 701177001743 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 701177001744 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 701177001745 HlyD family secretion protein; Region: HlyD_3; pfam13437 701177001746 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 701177001747 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 701177001748 DNA binding residues [nucleotide binding] 701177001749 dimer interface [polypeptide binding]; other site 701177001750 copper binding site [ion binding]; other site 701177001751 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 701177001752 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 701177001753 YadA-like C-terminal region; Region: YadA; pfam03895 701177001754 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 701177001755 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 701177001756 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 701177001757 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 701177001758 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 701177001759 Walker A/P-loop; other site 701177001760 ATP binding site [chemical binding]; other site 701177001761 Q-loop/lid; other site 701177001762 ABC transporter signature motif; other site 701177001763 Walker B; other site 701177001764 D-loop; other site 701177001765 H-loop/switch region; other site 701177001766 Uncharacterized protein family (UPF0014); Region: UPF0014; pfam03649 701177001767 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 701177001768 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 701177001769 oxidoreductase; Provisional; Region: PRK08017 701177001770 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 701177001771 NADP binding site [chemical binding]; other site 701177001772 active site 701177001773 steroid binding site; other site 701177001774 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 701177001775 active site 701177001776 catalytic triad [active] 701177001777 oxyanion hole [active] 701177001778 switch loop; other site 701177001779 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 701177001780 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 701177001781 Walker A/P-loop; other site 701177001782 ATP binding site [chemical binding]; other site 701177001783 Q-loop/lid; other site 701177001784 ABC transporter signature motif; other site 701177001785 Walker B; other site 701177001786 D-loop; other site 701177001787 H-loop/switch region; other site 701177001788 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 701177001789 FtsX-like permease family; Region: FtsX; pfam02687 701177001790 FtsX-like permease family; Region: FtsX; pfam02687 701177001791 hypothetical protein; Provisional; Region: PRK14710 701177001792 Winged helix-turn helix; Region: HTH_29; pfam13551 701177001793 Helix-turn-helix domain; Region: HTH_28; pfam13518 701177001794 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 701177001795 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 701177001796 active site residue [active] 701177001797 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 701177001798 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 701177001799 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 701177001800 dimerization interface [polypeptide binding]; other site 701177001801 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 701177001802 ureidoglycolate hydrolase; Provisional; Region: PRK03606 701177001803 DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163 701177001804 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 701177001805 Bacterial transcriptional regulator; Region: IclR; pfam01614 701177001806 glyoxylate carboligase; Provisional; Region: PRK11269 701177001807 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 701177001808 PYR/PP interface [polypeptide binding]; other site 701177001809 dimer interface [polypeptide binding]; other site 701177001810 TPP binding site [chemical binding]; other site 701177001811 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 701177001812 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 701177001813 TPP-binding site [chemical binding]; other site 701177001814 hydroxypyruvate isomerase; Provisional; Region: PRK09997 701177001815 tartronate semialdehyde reductase; Provisional; Region: PRK15059 701177001816 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 701177001817 nucleobase-cation-symport-1 (NCS1) transporters; solute-binding domain; Region: SLC-NCS1sbd; cd10323 701177001818 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 701177001819 Na binding site [ion binding]; other site 701177001820 substrate binding site [chemical binding]; other site 701177001821 allantoinase; Provisional; Region: PRK08044 701177001822 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 701177001823 active site 701177001824 putative uracil/xanthine transporter; Provisional; Region: PRK11412 701177001825 glycerate kinase II; Provisional; Region: PRK09932 701177001826 Uncharacterized protein, possibly involved in glyoxylate utilization [General function prediction only]; Region: GlxB; COG3257 701177001827 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 701177001828 Cupin domain; Region: Cupin_2; cl17218 701177001829 allantoate amidohydrolase; Region: AllC; TIGR03176 701177001830 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 701177001831 active site 701177001832 metal binding site [ion binding]; metal-binding site 701177001833 dimer interface [polypeptide binding]; other site 701177001834 ureidoglycolate dehydrogenase; Provisional; Region: PRK15025 701177001835 membrane protein FdrA; Validated; Region: PRK06091 701177001836 CoA binding domain; Region: CoA_binding; pfam02629 701177001837 CoA-ligase; Region: Ligase_CoA; pfam00549 701177001838 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 701177001839 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 701177001840 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 701177001841 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 701177001842 putative substrate binding site [chemical binding]; other site 701177001843 nucleotide binding site [chemical binding]; other site 701177001844 nucleotide binding site [chemical binding]; other site 701177001845 homodimer interface [polypeptide binding]; other site 701177001846 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 701177001847 ATP-grasp domain; Region: ATP-grasp; pfam02222 701177001848 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 701177001849 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 701177001850 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 701177001851 putative active site [active] 701177001852 putative metal binding site [ion binding]; other site 701177001853 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 701177001854 substrate binding site [chemical binding]; other site 701177001855 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 701177001856 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 701177001857 active site 701177001858 HIGH motif; other site 701177001859 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 701177001860 KMSKS motif; other site 701177001861 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 701177001862 tRNA binding surface [nucleotide binding]; other site 701177001863 anticodon binding site; other site 701177001864 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 701177001865 ribosome-associated protein; Provisional; Region: PRK11507 701177001866 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 701177001867 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 701177001868 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 701177001869 homodimer interface [polypeptide binding]; other site 701177001870 NADP binding site [chemical binding]; other site 701177001871 substrate binding site [chemical binding]; other site 701177001872 type-1 fimbrial protein subunit A; Provisional; Region: PRK15194 701177001873 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 701177001874 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 701177001875 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 701177001876 outer membrane usher protein FimD; Provisional; Region: PRK15198 701177001877 PapC N-terminal domain; Region: PapC_N; pfam13954 701177001878 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 701177001879 PapC C-terminal domain; Region: PapC_C; pfam13953 701177001880 fimbrial-like adhesin; Provisional; Region: fimH; PRK15199 701177001881 fimbrial-like adhesin protein SfmF; Provisional; Region: PRK09934 701177001882 transcriptional regulator FimZ; Provisional; Region: PRK09935 701177001883 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 701177001884 active site 701177001885 phosphorylation site [posttranslational modification] 701177001886 intermolecular recognition site; other site 701177001887 dimerization interface [polypeptide binding]; other site 701177001888 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 701177001889 DNA binding residues [nucleotide binding] 701177001890 dimerization interface [polypeptide binding]; other site 701177001891 P22-like integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial and phage integrases, including those similar to phage P22-like integrases, DLP12 and APSE-1; Region: INT_P22_C; cd01192 701177001892 Int/Topo IB signature motif; other site 701177001893 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 701177001894 DksA-like zinc finger domain containing protein; Region: PHA00080 701177001895 Protein of unknown function (DUF1382); Region: DUF1382; pfam07131 701177001896 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 701177001897 phage recombination protein Bet; Region: bet_lambda; TIGR01913 701177001898 Host-nuclease inhibitor protein Gam; Region: Gam; pfam06064 701177001899 FtsZ inhibitor protein; Reviewed; Region: kil; PRK11354 701177001900 Uncharacterized conserved protein [Function unknown]; Region: COG4933 701177001901 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 701177001902 Predicted transcriptional regulator [Transcription]; Region: COG2932 701177001903 sequence-specific DNA binding site [nucleotide binding]; other site 701177001904 salt bridge; other site 701177001905 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 701177001906 Catalytic site [active] 701177001907 Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197 701177001908 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 701177001909 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 701177001910 Replication protein P; Region: Phage_lambda_P; pfam06992 701177001911 multidrug efflux protein; Reviewed; Region: emrE; PRK09541 701177001912 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 701177001913 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 701177001914 catalytic residues [active] 701177001915 catalytic nucleophile [active] 701177001916 Recombinase; Region: Recombinase; pfam07508 701177001917 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 701177001918 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 701177001919 substrate binding site [chemical binding]; other site 701177001920 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 701177001921 hypothetical protein; Provisional; Region: PRK09741 701177001922 prophage protein NinE; Provisional; Region: PRK09689 701177001923 Protein of unknown function (DUF1364); Region: DUF1364; pfam07102 701177001924 endodeoxyribonuclease RUS; Reviewed; Region: PRK09786 701177001925 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 701177001926 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 701177001927 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 701177001928 trimer interface [polypeptide binding]; other site 701177001929 eyelet of channel; other site 701177001930 Lysis protein S; Region: Lysis_S; pfam04971 701177001931 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 701177001932 catalytic residues [active] 701177001933 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 701177001934 Bor protein; Region: Lambda_Bor; pfam06291 701177001935 Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471 701177001936 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 701177001937 gpW; Region: gpW; pfam02831 701177001938 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 701177001939 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 701177001940 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 701177001941 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 701177001942 tandem repeat interface [polypeptide binding]; other site 701177001943 oligomer interface [polypeptide binding]; other site 701177001944 active site residues [active] 701177001945 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 701177001946 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 701177001947 DNA packaging protein FI; Region: Packaging_FI; pfam14000 701177001948 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 701177001949 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 701177001950 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 701177001951 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 701177001952 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 701177001953 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894 701177001954 Minor tail protein T; Region: Phage_tail_T; pfam06223 701177001955 Phage-related minor tail protein [Function unknown]; Region: COG5281 701177001956 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 701177001957 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 701177001958 Phage-related protein [Function unknown]; Region: COG4718 701177001959 Phage-related protein [Function unknown]; Region: gp18; COG4672 701177001960 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 701177001961 MPN+ (JAMM) motif; other site 701177001962 Zinc-binding site [ion binding]; other site 701177001963 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 701177001964 NlpC/P60 family; Region: NLPC_P60; cl17555 701177001965 Phage-related protein, tail component [Function unknown]; Region: COG4723 701177001966 Phage-related protein, tail component [Function unknown]; Region: COG4733 701177001967 Putative phage tail protein; Region: Phage-tail_3; pfam13550 701177001968 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 701177001969 Fibronectin type III protein; Region: DUF3672; pfam12421 701177001970 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 701177001971 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 701177001972 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 701177001973 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 701177001974 Phage Tail Collar Domain; Region: Collar; pfam07484 701177001975 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 701177001976 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 701177001977 Methyltransferase domain; Region: Methyltransf_12; pfam08242 701177001978 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 701177001979 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 701177001980 TAP-like protein; Region: Abhydrolase_4; pfam08386 701177001981 outer membrane protease; Reviewed; Region: PRK10993 701177001982 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 701177001983 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 701177001984 sequence-specific DNA binding site [nucleotide binding]; other site 701177001985 salt bridge; other site 701177001986 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 701177001987 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 701177001988 Coenzyme A binding pocket [chemical binding]; other site 701177001989 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 701177001990 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 701177001991 hypothetical protein; Provisional; Region: PRK09936 701177001992 bacteriophage N4 receptor, outer membrane subunit; Provisional; Region: PRK09782 701177001993 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 701177001994 TPR motif; other site 701177001995 binding surface 701177001996 Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283 701177001997 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 701177001998 active site 701177001999 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 701177002000 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 701177002001 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 701177002002 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 701177002003 Transposase [DNA replication, recombination, and repair]; Region: COG5433 701177002004 Transposase [DNA replication, recombination, and repair]; Region: COG5433 701177002005 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 701177002006 RHS Repeat; Region: RHS_repeat; cl11982 701177002007 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 701177002008 PAAR motif; Region: PAAR_motif; pfam05488 701177002009 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 701177002010 RHS Repeat; Region: RHS_repeat; pfam05593 701177002011 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 701177002012 RHS Repeat; Region: RHS_repeat; cl11982 701177002013 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 701177002014 RHS Repeat; Region: RHS_repeat; pfam05593 701177002015 RHS Repeat; Region: RHS_repeat; cl11982 701177002016 RHS Repeat; Region: RHS_repeat; pfam05593 701177002017 RHS Repeat; Region: RHS_repeat; cl11982 701177002018 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 701177002019 RHS Repeat; Region: RHS_repeat; cl11982 701177002020 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 701177002021 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 701177002022 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 701177002023 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 701177002024 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 701177002025 sensor kinase CusS; Provisional; Region: PRK09835 701177002026 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 701177002027 dimerization interface [polypeptide binding]; other site 701177002028 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 701177002029 dimer interface [polypeptide binding]; other site 701177002030 phosphorylation site [posttranslational modification] 701177002031 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 701177002032 ATP binding site [chemical binding]; other site 701177002033 Mg2+ binding site [ion binding]; other site 701177002034 G-X-G motif; other site 701177002035 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 701177002036 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 701177002037 active site 701177002038 phosphorylation site [posttranslational modification] 701177002039 intermolecular recognition site; other site 701177002040 dimerization interface [polypeptide binding]; other site 701177002041 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 701177002042 DNA binding site [nucleotide binding] 701177002043 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 701177002044 periplasmic copper-binding protein; Provisional; Region: PRK09838 701177002045 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 701177002046 HlyD family secretion protein; Region: HlyD_3; pfam13437 701177002047 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 701177002048 phenylalanine transporter; Provisional; Region: PRK10249 701177002049 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 701177002050 Mechanosensitive ion channel; Region: MS_channel; pfam00924 701177002051 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 701177002052 dimer interface [polypeptide binding]; other site 701177002053 FMN binding site [chemical binding]; other site 701177002054 hypothetical protein; Provisional; Region: PRK10250 701177002055 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 701177002056 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 701177002057 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 701177002058 Hok/gef family; Region: HOK_GEF; pfam01848 701177002059 Hok/gef family; Region: HOK_GEF; pfam01848 701177002060 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 701177002061 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 701177002062 outer membrane receptor FepA; Provisional; Region: PRK13524 701177002063 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 701177002064 N-terminal plug; other site 701177002065 ligand-binding site [chemical binding]; other site 701177002066 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 701177002067 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 701177002068 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 701177002069 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 701177002070 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 701177002071 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 701177002072 acyl-activating enzyme (AAE) consensus motif; other site 701177002073 AMP binding site [chemical binding]; other site 701177002074 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 701177002075 LPS O-antigen length regulator; Provisional; Region: PRK10381 701177002076 Chain length determinant protein; Region: Wzz; pfam02706 701177002077 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 701177002078 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 701177002079 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 701177002080 Walker A/P-loop; other site 701177002081 ATP binding site [chemical binding]; other site 701177002082 Q-loop/lid; other site 701177002083 ABC transporter signature motif; other site 701177002084 Walker B; other site 701177002085 D-loop; other site 701177002086 H-loop/switch region; other site 701177002087 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 701177002088 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 701177002089 ABC-ATPase subunit interface; other site 701177002090 dimer interface [polypeptide binding]; other site 701177002091 putative PBP binding regions; other site 701177002092 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 701177002093 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 701177002094 ABC-ATPase subunit interface; other site 701177002095 dimer interface [polypeptide binding]; other site 701177002096 putative PBP binding regions; other site 701177002097 enterobactin exporter EntS; Provisional; Region: PRK10489 701177002098 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177002099 putative substrate translocation pore; other site 701177002100 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 701177002101 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 701177002102 siderophore binding site; other site 701177002103 isochorismate synthase EntC; Provisional; Region: PRK15016 701177002104 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 701177002105 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 701177002106 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 701177002107 acyl-activating enzyme (AAE) consensus motif; other site 701177002108 active site 701177002109 AMP binding site [chemical binding]; other site 701177002110 substrate binding site [chemical binding]; other site 701177002111 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 701177002112 hydrophobic substrate binding pocket; other site 701177002113 Isochorismatase family; Region: Isochorismatase; pfam00857 701177002114 active site 701177002115 conserved cis-peptide bond; other site 701177002116 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 701177002117 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 701177002118 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 701177002119 putative NAD(P) binding site [chemical binding]; other site 701177002120 active site 701177002121 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 701177002122 CoenzymeA binding site [chemical binding]; other site 701177002123 subunit interaction site [polypeptide binding]; other site 701177002124 PHB binding site; other site 701177002125 carbon starvation protein A; Provisional; Region: PRK15015 701177002126 Carbon starvation protein CstA; Region: CstA; pfam02554 701177002127 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 701177002128 Uncharacterized small protein [Function unknown]; Region: COG2879 701177002129 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 701177002130 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 701177002131 putative active site [active] 701177002132 metal binding site [ion binding]; metal-binding site 701177002133 methionine aminotransferase; Validated; Region: PRK09082 701177002134 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 701177002135 pyridoxal 5'-phosphate binding site [chemical binding]; other site 701177002136 homodimer interface [polypeptide binding]; other site 701177002137 catalytic residue [active] 701177002138 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 701177002139 ParB-like nuclease domain; Region: ParBc; pfam02195 701177002140 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 701177002141 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 701177002142 Active Sites [active] 701177002143 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 701177002144 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 701177002145 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 701177002146 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 701177002147 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 701177002148 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 701177002149 dimerization domain [polypeptide binding]; other site 701177002150 dimer interface [polypeptide binding]; other site 701177002151 catalytic residues [active] 701177002152 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 701177002153 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 701177002154 dimer interface [polypeptide binding]; other site 701177002155 decamer (pentamer of dimers) interface [polypeptide binding]; other site 701177002156 catalytic triad [active] 701177002157 peroxidatic and resolving cysteines [active] 701177002158 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 701177002159 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 701177002160 catalytic residue [active] 701177002161 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 701177002162 catalytic residues [active] 701177002163 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 701177002164 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 701177002165 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 701177002166 Ligand Binding Site [chemical binding]; other site 701177002167 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 701177002168 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 701177002169 NAD binding site [chemical binding]; other site 701177002170 catalytic Zn binding site [ion binding]; other site 701177002171 structural Zn binding site [ion binding]; other site 701177002172 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 701177002173 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 701177002174 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 701177002175 B1 nucleotide binding pocket [chemical binding]; other site 701177002176 B2 nucleotide binding pocket [chemical binding]; other site 701177002177 CAS motifs; other site 701177002178 active site 701177002179 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 701177002180 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 701177002181 transmembrane helices; other site 701177002182 triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096 701177002183 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 701177002184 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 701177002185 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 701177002186 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 701177002187 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 701177002188 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 701177002189 putative active site [active] 701177002190 (T/H)XGH motif; other site 701177002191 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 701177002192 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 701177002193 putative active site [active] 701177002194 heme pocket [chemical binding]; other site 701177002195 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 701177002196 ATP binding site [chemical binding]; other site 701177002197 Mg2+ binding site [ion binding]; other site 701177002198 G-X-G motif; other site 701177002199 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 701177002200 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 701177002201 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 701177002202 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 701177002203 DNA-binding site [nucleotide binding]; DNA binding site 701177002204 RNA-binding motif; other site 701177002205 chromosome condensation membrane protein; Provisional; Region: PRK14196 701177002206 Predicted amidohydrolase [General function prediction only]; Region: COG0388 701177002207 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 701177002208 putative active site [active] 701177002209 catalytic triad [active] 701177002210 putative dimer interface [polypeptide binding]; other site 701177002211 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 701177002212 lipoyl synthase; Provisional; Region: PRK05481 701177002213 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 701177002214 FeS/SAM binding site; other site 701177002215 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 701177002216 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 701177002217 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 701177002218 substrate binding pocket [chemical binding]; other site 701177002219 dimerization interface [polypeptide binding]; other site 701177002220 lipoate-protein ligase B; Provisional; Region: PRK14342 701177002221 hypothetical protein; Provisional; Region: PRK04998 701177002222 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 701177002223 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 701177002224 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 701177002225 rare lipoprotein A; Provisional; Region: PRK10672 701177002226 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 701177002227 Sporulation related domain; Region: SPOR; pfam05036 701177002228 cell wall shape-determining protein; Provisional; Region: PRK10794 701177002229 penicillin-binding protein 2; Provisional; Region: PRK10795 701177002230 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 701177002231 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 701177002232 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 701177002233 ribosome-associated protein; Provisional; Region: PRK11538 701177002234 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 701177002235 catalytic core [active] 701177002236 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 701177002237 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 701177002238 active site 701177002239 (T/H)XGH motif; other site 701177002240 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 701177002241 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 701177002242 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 701177002243 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 701177002244 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 701177002245 HIGH motif; other site 701177002246 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 701177002247 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 701177002248 active site 701177002249 KMSKS motif; other site 701177002250 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 701177002251 tRNA binding surface [nucleotide binding]; other site 701177002252 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 701177002253 hypothetical protein; Provisional; Region: PRK11032 701177002254 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 701177002255 Sel1-like repeats; Region: SEL1; smart00671 701177002256 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 701177002257 Sel1-like repeats; Region: SEL1; smart00671 701177002258 Sel1-like repeats; Region: SEL1; smart00671 701177002259 Sel1-like repeats; Region: SEL1; smart00671 701177002260 Sel1-like repeats; Region: SEL1; smart00671 701177002261 Sel1-like repeats; Region: SEL1; smart00671 701177002262 Sel1-like repeats; Region: SEL1; smart00671 701177002263 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 701177002264 DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271 701177002265 HSP70 interaction site [polypeptide binding]; other site 701177002266 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 701177002267 Sel1-like repeats; Region: SEL1; smart00671 701177002268 Sel1-like repeats; Region: SEL1; smart00671 701177002269 Sel1-like repeats; Region: SEL1; smart00671 701177002270 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 701177002271 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 701177002272 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 701177002273 nucleotide binding site [chemical binding]; other site 701177002274 putative NEF/HSP70 interaction site [polypeptide binding]; other site 701177002275 SBD interface [polypeptide binding]; other site 701177002276 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 701177002277 active site 701177002278 tetramer interface [polypeptide binding]; other site 701177002279 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 701177002280 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 701177002281 Walker A/P-loop; other site 701177002282 ATP binding site [chemical binding]; other site 701177002283 Q-loop/lid; other site 701177002284 ABC transporter signature motif; other site 701177002285 Walker B; other site 701177002286 D-loop; other site 701177002287 H-loop/switch region; other site 701177002288 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 701177002289 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 701177002290 dimer interface [polypeptide binding]; other site 701177002291 conserved gate region; other site 701177002292 putative PBP binding loops; other site 701177002293 ABC-ATPase subunit interface; other site 701177002294 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 701177002295 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 701177002296 dimer interface [polypeptide binding]; other site 701177002297 conserved gate region; other site 701177002298 putative PBP binding loops; other site 701177002299 ABC-ATPase subunit interface; other site 701177002300 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 701177002301 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 701177002302 substrate binding pocket [chemical binding]; other site 701177002303 membrane-bound complex binding site; other site 701177002304 hinge residues; other site 701177002305 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 701177002306 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 701177002307 putative active site [active] 701177002308 catalytic triad [active] 701177002309 putative dimer interface [polypeptide binding]; other site 701177002310 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 701177002311 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 701177002312 Transporter associated domain; Region: CorC_HlyC; smart01091 701177002313 metal-binding heat shock protein; Provisional; Region: PRK00016 701177002314 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 701177002315 PhoH-like protein; Region: PhoH; pfam02562 701177002316 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 701177002317 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 701177002318 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 701177002319 FeS/SAM binding site; other site 701177002320 TRAM domain; Region: TRAM; pfam01938 701177002321 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 701177002322 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 701177002323 asparagine synthetase B; Provisional; Region: asnB; PRK09431 701177002324 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 701177002325 active site 701177002326 dimer interface [polypeptide binding]; other site 701177002327 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 701177002328 Ligand Binding Site [chemical binding]; other site 701177002329 Molecular Tunnel; other site 701177002330 UMP phosphatase; Provisional; Region: PRK10444 701177002331 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 701177002332 active site 701177002333 motif I; other site 701177002334 motif II; other site 701177002335 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 701177002336 MarR family; Region: MarR; pfam01047 701177002337 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 701177002338 ROK family; Region: ROK; pfam00480 701177002339 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 701177002340 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 701177002341 active site 701177002342 dimer interface [polypeptide binding]; other site 701177002343 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 701177002344 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 701177002345 active site 701177002346 trimer interface [polypeptide binding]; other site 701177002347 allosteric site; other site 701177002348 active site lid [active] 701177002349 hexamer (dimer of trimers) interface [polypeptide binding]; other site 701177002350 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 701177002351 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 701177002352 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 701177002353 active site turn [active] 701177002354 phosphorylation site [posttranslational modification] 701177002355 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 701177002356 HPr interaction site; other site 701177002357 glycerol kinase (GK) interaction site [polypeptide binding]; other site 701177002358 active site 701177002359 phosphorylation site [posttranslational modification] 701177002360 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 701177002361 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 701177002362 active site 701177002363 HIGH motif; other site 701177002364 nucleotide binding site [chemical binding]; other site 701177002365 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 701177002366 KMSKS motif; other site 701177002367 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 701177002368 outer membrane porin, OprD family; Region: OprD; pfam03573 701177002369 YbfN-like lipoprotein; Region: YbfN; pfam13982 701177002370 ferric uptake regulator; Provisional; Region: fur; PRK09462 701177002371 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 701177002372 metal binding site 2 [ion binding]; metal-binding site 701177002373 putative DNA binding helix; other site 701177002374 metal binding site 1 [ion binding]; metal-binding site 701177002375 dimer interface [polypeptide binding]; other site 701177002376 structural Zn2+ binding site [ion binding]; other site 701177002377 flavodoxin FldA; Validated; Region: PRK09267 701177002378 LexA regulated protein; Provisional; Region: PRK11675 701177002379 acyl-CoA esterase; Provisional; Region: PRK10673 701177002380 PGAP1-like protein; Region: PGAP1; pfam07819 701177002381 replication initiation regulator SeqA; Provisional; Region: PRK11187 701177002382 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 701177002383 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 701177002384 active site 701177002385 substrate binding site [chemical binding]; other site 701177002386 metal binding site [ion binding]; metal-binding site 701177002387 putrescine transporter; Provisional; Region: potE; PRK10655 701177002388 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 701177002389 ornithine decarboxylase; Provisional; Region: PRK13578 701177002390 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 701177002391 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 701177002392 homodimer interface [polypeptide binding]; other site 701177002393 pyridoxal 5'-phosphate binding site [chemical binding]; other site 701177002394 catalytic residue [active] 701177002395 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 701177002396 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 701177002397 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 701177002398 active site 701177002399 phosphorylation site [posttranslational modification] 701177002400 intermolecular recognition site; other site 701177002401 dimerization interface [polypeptide binding]; other site 701177002402 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 701177002403 DNA binding site [nucleotide binding] 701177002404 sensor protein KdpD; Provisional; Region: PRK10490 701177002405 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 701177002406 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 701177002407 Ligand Binding Site [chemical binding]; other site 701177002408 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 701177002409 GAF domain; Region: GAF_3; pfam13492 701177002410 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 701177002411 dimer interface [polypeptide binding]; other site 701177002412 phosphorylation site [posttranslational modification] 701177002413 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 701177002414 ATP binding site [chemical binding]; other site 701177002415 Mg2+ binding site [ion binding]; other site 701177002416 G-X-G motif; other site 701177002417 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 701177002418 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 701177002419 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 701177002420 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 701177002421 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 701177002422 PAAR motif; Region: PAAR_motif; cl15808 701177002423 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 701177002424 RHS Repeat; Region: RHS_repeat; pfam05593 701177002425 RHS Repeat; Region: RHS_repeat; pfam05593 701177002426 RHS Repeat; Region: RHS_repeat; pfam05593 701177002427 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 701177002428 RHS Repeat; Region: RHS_repeat; pfam05593 701177002429 RHS Repeat; Region: RHS_repeat; pfam05593 701177002430 RHS protein; Region: RHS; pfam03527 701177002431 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 701177002432 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 701177002433 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 701177002434 Transposase [DNA replication, recombination, and repair]; Region: COG5433 701177002435 Transposase [DNA replication, recombination, and repair]; Region: COG5433 701177002436 hypothetical protein; Provisional; Region: PRK10167 701177002437 Uncharacterized conserved protein [Function unknown]; Region: COG3272 701177002438 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 701177002439 DNA photolyase; Region: DNA_photolyase; pfam00875 701177002440 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 701177002441 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177002442 POT family; Region: PTR2; pfam00854 701177002443 Uncharacterized conserved protein [Function unknown]; Region: COG0327 701177002444 metal-binding protein; Provisional; Region: PRK10799 701177002445 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 701177002446 sensor histidine kinase inhibitor, KipI family; Region: TIGR00370 701177002447 biotin-dependent carboxylase uncharacterized domain; Region: urea_amlyse_rel; TIGR00724 701177002448 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 701177002449 putative active site [active] 701177002450 endonuclease VIII; Provisional; Region: PRK10445 701177002451 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 701177002452 DNA binding site [nucleotide binding] 701177002453 catalytic residue [active] 701177002454 putative catalytic residues [active] 701177002455 H2TH interface [polypeptide binding]; other site 701177002456 intercalation triad [nucleotide binding]; other site 701177002457 substrate specificity determining residue; other site 701177002458 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 701177002459 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 701177002460 Putative ammonia monooxygenase; Region: AmoA; pfam05145 701177002461 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 701177002462 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 701177002463 Fimbrial protein; Region: Fimbrial; pfam00419 701177002464 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 701177002465 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 701177002466 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 701177002467 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 701177002468 PapC N-terminal domain; Region: PapC_N; pfam13954 701177002469 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 701177002470 PapC C-terminal domain; Region: PapC_C; pfam13953 701177002471 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 701177002472 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 701177002473 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 701177002474 dimer interface [polypeptide binding]; other site 701177002475 active site 701177002476 citrylCoA binding site [chemical binding]; other site 701177002477 NADH binding [chemical binding]; other site 701177002478 cationic pore residues; other site 701177002479 oxalacetate/citrate binding site [chemical binding]; other site 701177002480 coenzyme A binding site [chemical binding]; other site 701177002481 catalytic triad [active] 701177002482 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 701177002483 Iron-sulfur protein interface; other site 701177002484 proximal quinone binding site [chemical binding]; other site 701177002485 SdhD (CybS) interface [polypeptide binding]; other site 701177002486 proximal heme binding site [chemical binding]; other site 701177002487 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 701177002488 SdhC subunit interface [polypeptide binding]; other site 701177002489 proximal heme binding site [chemical binding]; other site 701177002490 cardiolipin binding site; other site 701177002491 Iron-sulfur protein interface; other site 701177002492 proximal quinone binding site [chemical binding]; other site 701177002493 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 701177002494 L-aspartate oxidase; Provisional; Region: PRK06175 701177002495 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 701177002496 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 701177002497 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 701177002498 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 701177002499 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 701177002500 TPP-binding site [chemical binding]; other site 701177002501 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 701177002502 dimer interface [polypeptide binding]; other site 701177002503 PYR/PP interface [polypeptide binding]; other site 701177002504 TPP binding site [chemical binding]; other site 701177002505 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 701177002506 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 701177002507 E3 interaction surface; other site 701177002508 lipoyl attachment site [posttranslational modification]; other site 701177002509 e3 binding domain; Region: E3_binding; pfam02817 701177002510 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 701177002511 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 701177002512 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 701177002513 CoA-ligase; Region: Ligase_CoA; pfam00549 701177002514 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 701177002515 CoA binding domain; Region: CoA_binding; smart00881 701177002516 CoA-ligase; Region: Ligase_CoA; pfam00549 701177002517 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 701177002518 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 701177002519 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 701177002520 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 701177002521 dimerization interface [polypeptide binding]; other site 701177002522 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 701177002523 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 701177002524 Walker A motif; other site 701177002525 homodimer interface [polypeptide binding]; other site 701177002526 ATP binding site [chemical binding]; other site 701177002527 hydroxycobalamin binding site [chemical binding]; other site 701177002528 Walker B motif; other site 701177002529 putative fumarate hydratase; Provisional; Region: PRK15392 701177002530 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 701177002531 Fumarase C-terminus; Region: Fumerase_C; pfam05683 701177002532 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 701177002533 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 701177002534 Domain of unknown function (DUF4387); Region: DUF4387; pfam14330 701177002535 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 701177002536 Methylaspartate ammonia-lyase [Amino acid transport and metabolism]; Region: Mal; COG3799 701177002537 Methylaspartate ammonia lyase (3-methylaspartase, MAL) is a homodimeric enzyme, catalyzing the magnesium-dependent reversible alpha,beta-elimination of ammonia from L-threo-(2S,3S)-3-methylaspartic acid to mesaconic acid. This reaction is part of the...; Region: MAL; cd03314 701177002538 dimer interface [polypeptide binding]; other site 701177002539 active site 701177002540 Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to...; Region: Glm_e; cd00245 701177002541 substrate binding site [chemical binding]; other site 701177002542 B12 cofactor binding site [chemical binding]; other site 701177002543 heterodimer (sigma-epsilon) interface [polypeptide binding]; other site 701177002544 homodimer (epsilon-epsilon) interface [polypeptide binding]; other site 701177002545 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 701177002546 conserved hypothetical protein; Region: glmL_fam; TIGR01319 701177002547 nucleotide binding site [chemical binding]; other site 701177002548 B12 binding domain of glutamate mutase (Glm). Glutamate mutase catalysis the conversion of (S)-glutamate with (2S,3S)-3-methylaspartate. The rearrangement reaction is initiated by the extraction of a hydrogen from the protein-bound substrate by a 5'...; Region: Glm_B12_BD; cd02072 701177002549 B12 binding site [chemical binding]; other site 701177002550 heterodimer interface [polypeptide binding]; other site 701177002551 cobalt ligand [ion binding]; other site 701177002552 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 701177002553 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 701177002554 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 701177002555 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 701177002556 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 701177002557 hypothetical protein; Provisional; Region: PRK10588 701177002558 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 701177002559 active site 701177002560 colicin uptake protein TolQ; Provisional; Region: PRK10801 701177002561 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 701177002562 colicin uptake protein TolR; Provisional; Region: PRK11024 701177002563 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 701177002564 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 701177002565 TolA C-terminal; Region: TolA; pfam06519 701177002566 translocation protein TolB; Provisional; Region: tolB; PRK03629 701177002567 TolB amino-terminal domain; Region: TolB_N; pfam04052 701177002568 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 701177002569 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 701177002570 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 701177002571 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 701177002572 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 701177002573 ligand binding site [chemical binding]; other site 701177002574 tol-pal system protein YbgF; Provisional; Region: PRK10803 701177002575 Tetratricopeptide repeat; Region: TPR_6; pfam13174 701177002576 Tetratricopeptide repeat; Region: TPR_6; pfam13174 701177002577 quinolinate synthetase; Provisional; Region: PRK09375 701177002578 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 701177002579 zinc transporter ZitB; Provisional; Region: PRK03557 701177002580 YbgS-like protein; Region: YbgS; pfam13985 701177002581 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 701177002582 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 701177002583 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 701177002584 catalytic core [active] 701177002585 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 701177002586 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 701177002587 active site 701177002588 catalytic residues [active] 701177002589 galactokinase; Provisional; Region: PRK05101 701177002590 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 701177002591 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 701177002592 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 701177002593 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 701177002594 dimer interface [polypeptide binding]; other site 701177002595 active site 701177002596 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 701177002597 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 701177002598 NAD binding site [chemical binding]; other site 701177002599 homodimer interface [polypeptide binding]; other site 701177002600 active site 701177002601 substrate binding site [chemical binding]; other site 701177002602 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 701177002603 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 701177002604 Walker A/P-loop; other site 701177002605 ATP binding site [chemical binding]; other site 701177002606 Q-loop/lid; other site 701177002607 ABC transporter signature motif; other site 701177002608 Walker B; other site 701177002609 D-loop; other site 701177002610 H-loop/switch region; other site 701177002611 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 701177002612 Walker A/P-loop; other site 701177002613 ATP binding site [chemical binding]; other site 701177002614 Q-loop/lid; other site 701177002615 ABC transporter signature motif; other site 701177002616 Walker B; other site 701177002617 D-loop; other site 701177002618 H-loop/switch region; other site 701177002619 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 701177002620 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 701177002621 molybdenum-pterin binding domain; Region: Mop; TIGR00638 701177002622 TOBE domain; Region: TOBE; pfam03459 701177002623 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 701177002624 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 701177002625 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 701177002626 substrate binding pocket [chemical binding]; other site 701177002627 membrane-bound complex binding site; other site 701177002628 hinge residues; other site 701177002629 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 701177002630 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 701177002631 putative PBP binding loops; other site 701177002632 ABC-ATPase subunit interface; other site 701177002633 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 701177002634 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 701177002635 Walker A/P-loop; other site 701177002636 ATP binding site [chemical binding]; other site 701177002637 Q-loop/lid; other site 701177002638 ABC transporter signature motif; other site 701177002639 Walker B; other site 701177002640 D-loop; other site 701177002641 H-loop/switch region; other site 701177002642 molybdenum-pterin binding domain; Region: Mop; TIGR00638 701177002643 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 701177002644 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 701177002645 motif II; other site 701177002646 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 701177002647 6-phosphogluconolactonase; Provisional; Region: PRK11028 701177002648 Transcriptional regulator [Transcription]; Region: LysR; COG0583 701177002649 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 701177002650 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 701177002651 putative dimerization interface [polypeptide binding]; other site 701177002652 PrpF protein; Region: PrpF; pfam04303 701177002653 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 701177002654 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 701177002655 transmembrane helices; other site 701177002656 putative hydratase; Provisional; Region: PRK11413 701177002657 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 701177002658 substrate binding site [chemical binding]; other site 701177002659 ligand binding site [chemical binding]; other site 701177002660 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 701177002661 substrate binding site [chemical binding]; other site 701177002662 acyl-CoA thioesterase; Provisional; Region: PRK10531 701177002663 putative pectinesterase; Region: PLN02432; cl01911 701177002664 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 701177002665 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 701177002666 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 701177002667 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 701177002668 dimer interface [polypeptide binding]; other site 701177002669 active site 701177002670 Int/Topo IB signature motif; other site 701177002671 Excisionase-like protein; Region: Exc; pfam07825 701177002672 DksA-like zinc finger domain containing protein; Region: PHA00080 701177002673 Protein of unknown function (DUF1382); Region: DUF1382; pfam07131 701177002674 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 701177002675 RecT family; Region: RecT; cl04285 701177002676 Host-nuclease inhibitor protein Gam; Region: Gam; pfam06064 701177002677 Lambda Phage CIII; Region: Lambda_CIII; pfam02061 701177002678 Protein of unknown function (DUF2528); Region: DUF2528; pfam10800 701177002679 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 701177002680 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 701177002681 non-specific DNA binding site [nucleotide binding]; other site 701177002682 salt bridge; other site 701177002683 sequence-specific DNA binding site [nucleotide binding]; other site 701177002684 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 701177002685 Catalytic site [active] 701177002686 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 701177002687 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 701177002688 non-specific DNA binding site [nucleotide binding]; other site 701177002689 salt bridge; other site 701177002690 sequence-specific DNA binding site [nucleotide binding]; other site 701177002691 Bacteriophage CII protein; Region: Phage_CII; pfam05269 701177002692 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 701177002693 Replication protein P; Region: Phage_lambda_P; pfam06992 701177002694 NinB protein; Region: NinB; pfam05772 701177002695 NINE Protein; Region: NinE; pfam05322 701177002696 NinF protein; Region: NinF; pfam05810 701177002697 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 701177002698 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 701177002699 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 701177002700 active site 701177002701 metal binding site [ion binding]; metal-binding site 701177002702 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3528 701177002703 Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323 701177002704 Protein of unknown function (DUF3927); Region: DUF3927; pfam13064 701177002705 Lysis protein S; Region: Lysis_S; pfam04971 701177002706 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 701177002707 catalytic residues [active] 701177002708 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 701177002709 Protein of unknown function (DUF1441); Region: DUF1441; pfam07278 701177002710 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 701177002711 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 701177002712 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 701177002713 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 701177002714 Uncharacterized conserved protein [Function unknown]; Region: COG5471 701177002715 ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; pfam13856 701177002716 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 701177002717 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 701177002718 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 701177002719 Bacterial Ig-like domain 2; Region: BID_2; smart00635 701177002720 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; cl06106 701177002721 Minor tail protein T; Region: Phage_tail_T; pfam06223 701177002722 Phage-related minor tail protein [Function unknown]; Region: COG5281 701177002723 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 701177002724 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 701177002725 Phage-related protein [Function unknown]; Region: COG4718 701177002726 Phage-related protein [Function unknown]; Region: gp18; COG4672 701177002727 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 701177002728 MPN+ (JAMM) motif; other site 701177002729 Zinc-binding site [ion binding]; other site 701177002730 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 701177002731 NlpC/P60 family; Region: NLPC_P60; cl17555 701177002732 Phage-related protein, tail component [Function unknown]; Region: COG4723 701177002733 Phage-related protein, tail component [Function unknown]; Region: COG4733 701177002734 Putative phage tail protein; Region: Phage-tail_3; pfam13550 701177002735 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 701177002736 Fibronectin type III protein; Region: DUF3672; pfam12421 701177002737 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 701177002738 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 701177002739 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 701177002740 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 701177002741 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 701177002742 non-LEE encoded effector protein NleB; Provisional; Region: PRK15382 701177002743 type III secretion system protein; Provisional; Region: PRK15384; cl14665 701177002744 NFkB-p65-degrading zinc protease; Region: Peptidase_M85; pfam13678 701177002745 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 701177002746 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512 701177002747 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 701177002748 substrate binding site [chemical binding]; other site 701177002749 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 701177002750 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 701177002751 inhibitor-cofactor binding pocket; inhibition site 701177002752 pyridoxal 5'-phosphate binding site [chemical binding]; other site 701177002753 catalytic residue [active] 701177002754 biotin synthase; Provisional; Region: PRK15108 701177002755 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 701177002756 FeS/SAM binding site; other site 701177002757 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 701177002758 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 701177002759 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 701177002760 substrate-cofactor binding pocket; other site 701177002761 pyridoxal 5'-phosphate binding site [chemical binding]; other site 701177002762 catalytic residue [active] 701177002763 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 701177002764 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 701177002765 S-adenosylmethionine binding site [chemical binding]; other site 701177002766 AAA domain; Region: AAA_26; pfam13500 701177002767 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 701177002768 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 701177002769 ADP binding site [chemical binding]; other site 701177002770 excinuclease ABC subunit B; Provisional; Region: PRK05298 701177002771 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 701177002772 ATP binding site [chemical binding]; other site 701177002773 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 701177002774 nucleotide binding region [chemical binding]; other site 701177002775 ATP-binding site [chemical binding]; other site 701177002776 Ultra-violet resistance protein B; Region: UvrB; pfam12344 701177002777 UvrB/uvrC motif; Region: UVR; pfam02151 701177002778 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 701177002779 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 701177002780 putative substrate binding pocket [chemical binding]; other site 701177002781 dimer interface [polypeptide binding]; other site 701177002782 phosphate binding site [ion binding]; other site 701177002783 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 701177002784 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 701177002785 FeS/SAM binding site; other site 701177002786 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 701177002787 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 701177002788 MPT binding site; other site 701177002789 trimer interface [polypeptide binding]; other site 701177002790 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 701177002791 trimer interface [polypeptide binding]; other site 701177002792 dimer interface [polypeptide binding]; other site 701177002793 putative active site [active] 701177002794 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 701177002795 MoaE interaction surface [polypeptide binding]; other site 701177002796 MoeB interaction surface [polypeptide binding]; other site 701177002797 thiocarboxylated glycine; other site 701177002798 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 701177002799 MoaE homodimer interface [polypeptide binding]; other site 701177002800 MoaD interaction [polypeptide binding]; other site 701177002801 active site residues [active] 701177002802 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 701177002803 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 701177002804 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 701177002805 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 701177002806 Predicted integral membrane protein [Function unknown]; Region: COG0392 701177002807 cardiolipin synthase 2; Provisional; Region: PRK11263 701177002808 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 701177002809 putative active site [active] 701177002810 catalytic site [active] 701177002811 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 701177002812 putative active site [active] 701177002813 catalytic site [active] 701177002814 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 701177002815 putative catalytic site [active] 701177002816 putative metal binding site [ion binding]; other site 701177002817 putative phosphate binding site [ion binding]; other site 701177002818 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 701177002819 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 701177002820 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 701177002821 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 701177002822 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 701177002823 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 701177002824 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 701177002825 Walker A/P-loop; other site 701177002826 ATP binding site [chemical binding]; other site 701177002827 Q-loop/lid; other site 701177002828 ABC transporter signature motif; other site 701177002829 Walker B; other site 701177002830 D-loop; other site 701177002831 H-loop/switch region; other site 701177002832 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 701177002833 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 701177002834 Walker A/P-loop; other site 701177002835 ATP binding site [chemical binding]; other site 701177002836 Q-loop/lid; other site 701177002837 ABC transporter signature motif; other site 701177002838 Walker B; other site 701177002839 D-loop; other site 701177002840 H-loop/switch region; other site 701177002841 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 701177002842 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 701177002843 HlyD family secretion protein; Region: HlyD_3; pfam13437 701177002844 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 701177002845 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 701177002846 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 701177002847 helicase 45; Provisional; Region: PTZ00424 701177002848 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 701177002849 ATP binding site [chemical binding]; other site 701177002850 Mg++ binding site [ion binding]; other site 701177002851 motif III; other site 701177002852 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 701177002853 nucleotide binding region [chemical binding]; other site 701177002854 ATP-binding site [chemical binding]; other site 701177002855 SopA-like central domain; Region: SopA; pfam13981 701177002856 SopA-like catalytic domain; Region: SopA_C; pfam13979 701177002857 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 701177002858 DEAD_2; Region: DEAD_2; pfam06733 701177002859 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 701177002860 glycosyl transferase family protein; Provisional; Region: PRK08136 701177002861 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 701177002862 putative dehydrogenase; Provisional; Region: PRK10098 701177002863 hypothetical protein; Provisional; Region: PRK10259 701177002864 hypothetical protein; Provisional; Region: PRK11019 701177002865 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 701177002866 catecholate siderophore receptor Fiu; Provisional; Region: PRK09840 701177002867 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 701177002868 N-terminal plug; other site 701177002869 ligand-binding site [chemical binding]; other site 701177002870 hypothetical protein; Provisional; Region: PRK10259 701177002871 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 701177002872 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 701177002873 putative mechanosensitive channel protein; Provisional; Region: PRK11465 701177002874 Mechanosensitive ion channel; Region: MS_channel; pfam00924 701177002875 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 701177002876 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 701177002877 Walker A/P-loop; other site 701177002878 ATP binding site [chemical binding]; other site 701177002879 Q-loop/lid; other site 701177002880 ABC transporter signature motif; other site 701177002881 Walker B; other site 701177002882 D-loop; other site 701177002883 H-loop/switch region; other site 701177002884 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 701177002885 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 701177002886 dimer interface [polypeptide binding]; other site 701177002887 conserved gate region; other site 701177002888 putative PBP binding loops; other site 701177002889 ABC-ATPase subunit interface; other site 701177002890 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 701177002891 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 701177002892 substrate binding pocket [chemical binding]; other site 701177002893 membrane-bound complex binding site; other site 701177002894 hinge residues; other site 701177002895 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 701177002896 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 701177002897 dimerization interface [polypeptide binding]; other site 701177002898 DPS ferroxidase diiron center [ion binding]; other site 701177002899 ion pore; other site 701177002900 threonine and homoserine efflux system; Provisional; Region: PRK10532 701177002901 EamA-like transporter family; Region: EamA; pfam00892 701177002902 outer membrane protein X; Provisional; Region: ompX; PRK09408 701177002903 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 701177002904 Sulfatase; Region: Sulfatase; pfam00884 701177002905 manganese transport regulator MntR; Provisional; Region: PRK11050 701177002906 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 701177002907 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 701177002908 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 701177002909 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 701177002910 transmembrane helices; other site 701177002911 L,D-transpeptidase; Provisional; Region: PRK10260 701177002912 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 701177002913 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 701177002914 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 701177002915 Walker A/P-loop; other site 701177002916 ATP binding site [chemical binding]; other site 701177002917 Q-loop/lid; other site 701177002918 ABC transporter signature motif; other site 701177002919 Walker B; other site 701177002920 D-loop; other site 701177002921 H-loop/switch region; other site 701177002922 ABC transporter; Region: ABC_tran_2; pfam12848 701177002923 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 701177002924 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 701177002925 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 701177002926 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 701177002927 active site 701177002928 motif I; other site 701177002929 motif II; other site 701177002930 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 701177002931 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 701177002932 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 701177002933 dimer interface [polypeptide binding]; other site 701177002934 active site 701177002935 glycine loop; other site 701177002936 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 701177002937 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 701177002938 active site 701177002939 intersubunit interactions; other site 701177002940 catalytic residue [active] 701177002941 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 701177002942 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 701177002943 ATP binding site [chemical binding]; other site 701177002944 substrate interface [chemical binding]; other site 701177002945 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 701177002946 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 701177002947 dimer interface [polypeptide binding]; other site 701177002948 putative functional site; other site 701177002949 putative MPT binding site; other site 701177002950 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 701177002951 catalytic nucleophile [active] 701177002952 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 701177002953 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 701177002954 Walker A/P-loop; other site 701177002955 ATP binding site [chemical binding]; other site 701177002956 Q-loop/lid; other site 701177002957 ABC transporter signature motif; other site 701177002958 Walker B; other site 701177002959 D-loop; other site 701177002960 H-loop/switch region; other site 701177002961 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 701177002962 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 701177002963 Walker A/P-loop; other site 701177002964 ATP binding site [chemical binding]; other site 701177002965 Q-loop/lid; other site 701177002966 ABC transporter signature motif; other site 701177002967 Walker B; other site 701177002968 D-loop; other site 701177002969 H-loop/switch region; other site 701177002970 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 701177002971 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 701177002972 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 701177002973 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 701177002974 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 701177002975 dimer interface [polypeptide binding]; other site 701177002976 conserved gate region; other site 701177002977 putative PBP binding loops; other site 701177002978 ABC-ATPase subunit interface; other site 701177002979 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 701177002980 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 701177002981 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 701177002982 dimer interface [polypeptide binding]; other site 701177002983 conserved gate region; other site 701177002984 putative PBP binding loops; other site 701177002985 ABC-ATPase subunit interface; other site 701177002986 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 701177002987 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 701177002988 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 701177002989 metal binding site [ion binding]; metal-binding site 701177002990 active site 701177002991 I-site; other site 701177002992 Predicted transcriptional regulator [Transcription]; Region: COG2944 701177002993 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 701177002994 non-specific DNA binding site [nucleotide binding]; other site 701177002995 salt bridge; other site 701177002996 sequence-specific DNA binding site [nucleotide binding]; other site 701177002997 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4737 701177002998 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 701177002999 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 701177003000 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 701177003001 FeS/SAM binding site; other site 701177003002 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 701177003003 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 701177003004 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 701177003005 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 701177003006 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 701177003007 putative C-terminal domain interface [polypeptide binding]; other site 701177003008 putative GSH binding site (G-site) [chemical binding]; other site 701177003009 putative dimer interface [polypeptide binding]; other site 701177003010 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 701177003011 N-terminal domain interface [polypeptide binding]; other site 701177003012 dimer interface [polypeptide binding]; other site 701177003013 substrate binding pocket (H-site) [chemical binding]; other site 701177003014 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 701177003015 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 701177003016 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 701177003017 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 701177003018 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 701177003019 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 701177003020 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 701177003021 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 701177003022 active site 701177003023 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 701177003024 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177003025 putative substrate translocation pore; other site 701177003026 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 701177003027 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 701177003028 active site 701177003029 motif I; other site 701177003030 motif II; other site 701177003031 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 701177003032 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 701177003033 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177003034 putative substrate translocation pore; other site 701177003035 Major Facilitator Superfamily; Region: MFS_1; pfam07690 701177003036 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 701177003037 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 701177003038 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 701177003039 putative transporter; Provisional; Region: PRK04972 701177003040 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 701177003041 TrkA-C domain; Region: TrkA_C; pfam02080 701177003042 TrkA-C domain; Region: TrkA_C; pfam02080 701177003043 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 701177003044 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 701177003045 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 701177003046 GSH binding site [chemical binding]; other site 701177003047 catalytic residues [active] 701177003048 Protein of unknown function (DUF1418); Region: DUF1418; cl11648 701177003049 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 701177003050 dimer interface [polypeptide binding]; other site 701177003051 FMN binding site [chemical binding]; other site 701177003052 NADPH bind site [chemical binding]; other site 701177003053 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 701177003054 RimK-like ATP-grasp domain; Region: RimK; pfam08443 701177003055 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 701177003056 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 701177003057 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 701177003058 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 701177003059 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 701177003060 Walker A/P-loop; other site 701177003061 ATP binding site [chemical binding]; other site 701177003062 Q-loop/lid; other site 701177003063 ABC transporter signature motif; other site 701177003064 Walker B; other site 701177003065 D-loop; other site 701177003066 H-loop/switch region; other site 701177003067 TOBE domain; Region: TOBE_2; pfam08402 701177003068 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 701177003069 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 701177003070 dimer interface [polypeptide binding]; other site 701177003071 conserved gate region; other site 701177003072 putative PBP binding loops; other site 701177003073 ABC-ATPase subunit interface; other site 701177003074 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 701177003075 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 701177003076 dimer interface [polypeptide binding]; other site 701177003077 conserved gate region; other site 701177003078 putative PBP binding loops; other site 701177003079 ABC-ATPase subunit interface; other site 701177003080 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 701177003081 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 701177003082 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 701177003083 S-adenosylmethionine binding site [chemical binding]; other site 701177003084 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 701177003085 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 701177003086 active site 701177003087 P-loop; other site 701177003088 phosphorylation site [posttranslational modification] 701177003089 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 701177003090 Sulfatase; Region: Sulfatase; cl17466 701177003091 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 701177003092 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 701177003093 substrate binding pocket [chemical binding]; other site 701177003094 membrane-bound complex binding site; other site 701177003095 hinge residues; other site 701177003096 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 701177003097 dimer interface [polypeptide binding]; other site 701177003098 conserved gate region; other site 701177003099 putative PBP binding loops; other site 701177003100 ABC-ATPase subunit interface; other site 701177003101 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 701177003102 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 701177003103 dimer interface [polypeptide binding]; other site 701177003104 conserved gate region; other site 701177003105 putative PBP binding loops; other site 701177003106 ABC-ATPase subunit interface; other site 701177003107 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 701177003108 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 701177003109 substrate binding pocket [chemical binding]; other site 701177003110 membrane-bound complex binding site; other site 701177003111 hinge residues; other site 701177003112 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 701177003113 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 701177003114 Walker A/P-loop; other site 701177003115 ATP binding site [chemical binding]; other site 701177003116 Q-loop/lid; other site 701177003117 ABC transporter signature motif; other site 701177003118 Walker B; other site 701177003119 D-loop; other site 701177003120 H-loop/switch region; other site 701177003121 putative lipoprotein; Provisional; Region: PRK10533 701177003122 hypothetical protein; Provisional; Region: PRK02877 701177003123 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 701177003124 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 701177003125 amidase catalytic site [active] 701177003126 Zn binding residues [ion binding]; other site 701177003127 substrate binding site [chemical binding]; other site 701177003128 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 701177003129 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 701177003130 NAD(P) binding site [chemical binding]; other site 701177003131 active site 701177003132 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 701177003133 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 701177003134 putative NAD(P) binding site [chemical binding]; other site 701177003135 putative active site [active] 701177003136 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 701177003137 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 701177003138 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 701177003139 tetramer interface [polypeptide binding]; other site 701177003140 pyridoxal 5'-phosphate binding site [chemical binding]; other site 701177003141 catalytic residue [active] 701177003142 pyruvate dehydrogenase; Provisional; Region: PRK09124 701177003143 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 701177003144 PYR/PP interface [polypeptide binding]; other site 701177003145 dimer interface [polypeptide binding]; other site 701177003146 tetramer interface [polypeptide binding]; other site 701177003147 TPP binding site [chemical binding]; other site 701177003148 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 701177003149 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 701177003150 TPP-binding site [chemical binding]; other site 701177003151 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 701177003152 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 701177003153 FAD binding pocket [chemical binding]; other site 701177003154 FAD binding motif [chemical binding]; other site 701177003155 phosphate binding motif [ion binding]; other site 701177003156 beta-alpha-beta structure motif; other site 701177003157 NAD binding pocket [chemical binding]; other site 701177003158 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 701177003159 catalytic loop [active] 701177003160 iron binding site [ion binding]; other site 701177003161 hybrid cluster protein; Provisional; Region: PRK05290 701177003162 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 701177003163 ACS interaction site; other site 701177003164 CODH interaction site; other site 701177003165 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 701177003166 hybrid metal cluster; other site 701177003167 Predicted membrane protein [Function unknown]; Region: COG2431 701177003168 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 701177003169 amphipathic channel; other site 701177003170 Asn-Pro-Ala signature motifs; other site 701177003171 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 701177003172 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 701177003173 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 701177003174 putative active site [active] 701177003175 putative metal-binding site [ion binding]; other site 701177003176 Protein of unknown function (DUF535); Region: DUF535; pfam04393 701177003177 macrolide transporter subunit MacA; Provisional; Region: PRK11578 701177003178 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 701177003179 HlyD family secretion protein; Region: HlyD_3; pfam13437 701177003180 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 701177003181 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 701177003182 Walker A/P-loop; other site 701177003183 ATP binding site [chemical binding]; other site 701177003184 Q-loop/lid; other site 701177003185 ABC transporter signature motif; other site 701177003186 Walker B; other site 701177003187 D-loop; other site 701177003188 H-loop/switch region; other site 701177003189 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 701177003190 FtsX-like permease family; Region: FtsX; pfam02687 701177003191 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 701177003192 DNA-binding site [nucleotide binding]; DNA binding site 701177003193 RNA-binding motif; other site 701177003194 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 701177003195 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 701177003196 Clp amino terminal domain; Region: Clp_N; pfam02861 701177003197 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 701177003198 Walker A motif; other site 701177003199 ATP binding site [chemical binding]; other site 701177003200 Walker B motif; other site 701177003201 arginine finger; other site 701177003202 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 701177003203 Walker A motif; other site 701177003204 ATP binding site [chemical binding]; other site 701177003205 Walker B motif; other site 701177003206 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 701177003207 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 701177003208 rRNA binding site [nucleotide binding]; other site 701177003209 predicted 30S ribosome binding site; other site 701177003210 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 701177003211 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 701177003212 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 701177003213 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 701177003214 Walker A/P-loop; other site 701177003215 ATP binding site [chemical binding]; other site 701177003216 Q-loop/lid; other site 701177003217 ABC transporter signature motif; other site 701177003218 Walker B; other site 701177003219 D-loop; other site 701177003220 H-loop/switch region; other site 701177003221 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 701177003222 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 701177003223 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 701177003224 Walker A/P-loop; other site 701177003225 ATP binding site [chemical binding]; other site 701177003226 Q-loop/lid; other site 701177003227 ABC transporter signature motif; other site 701177003228 Walker B; other site 701177003229 D-loop; other site 701177003230 H-loop/switch region; other site 701177003231 thioredoxin reductase; Provisional; Region: PRK10262 701177003232 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 701177003233 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 701177003234 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 701177003235 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 701177003236 putative DNA binding site [nucleotide binding]; other site 701177003237 putative Zn2+ binding site [ion binding]; other site 701177003238 AsnC family; Region: AsnC_trans_reg; pfam01037 701177003239 DNA translocase FtsK; Provisional; Region: PRK10263 701177003240 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 701177003241 DNA translocase FtsK; Provisional; Region: PRK10263 701177003242 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 701177003243 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 701177003244 periplasmic chaperone LolA; Region: lolA; TIGR00547 701177003245 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 701177003246 recombination factor protein RarA; Reviewed; Region: PRK13342 701177003247 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 701177003248 Walker A motif; other site 701177003249 ATP binding site [chemical binding]; other site 701177003250 Walker B motif; other site 701177003251 arginine finger; other site 701177003252 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 701177003253 seryl-tRNA synthetase; Provisional; Region: PRK05431 701177003254 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 701177003255 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 701177003256 dimer interface [polypeptide binding]; other site 701177003257 active site 701177003258 motif 1; other site 701177003259 motif 2; other site 701177003260 motif 3; other site 701177003261 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 701177003262 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 701177003263 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 701177003264 putative [Fe4-S4] binding site [ion binding]; other site 701177003265 putative molybdopterin cofactor binding site [chemical binding]; other site 701177003266 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 701177003267 putative molybdopterin cofactor binding site; other site 701177003268 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 701177003269 4Fe-4S binding domain; Region: Fer4; pfam00037 701177003270 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 701177003271 Isochorismatase family; Region: Isochorismatase; pfam00857 701177003272 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 701177003273 catalytic triad [active] 701177003274 dimer interface [polypeptide binding]; other site 701177003275 conserved cis-peptide bond; other site 701177003276 putative MFS family transporter protein; Provisional; Region: PRK03633 701177003277 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177003278 putative substrate translocation pore; other site 701177003279 Amino acid permease; Region: AA_permease_2; pfam13520 701177003280 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 701177003281 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 701177003282 FeS/SAM binding site; other site 701177003283 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 701177003284 Pyruvate formate lyase 1; Region: PFL1; cd01678 701177003285 coenzyme A binding site [chemical binding]; other site 701177003286 active site 701177003287 catalytic residues [active] 701177003288 glycine loop; other site 701177003289 formate transporter; Provisional; Region: PRK10805 701177003290 uncharacterized domain; Region: TIGR00702 701177003291 YcaO-like family; Region: YcaO; pfam02624 701177003292 Predicted membrane protein [Function unknown]; Region: COG2323 701177003293 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 701177003294 homodimer interface [polypeptide binding]; other site 701177003295 substrate-cofactor binding pocket; other site 701177003296 pyridoxal 5'-phosphate binding site [chemical binding]; other site 701177003297 catalytic residue [active] 701177003298 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 701177003299 Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554 701177003300 hinge; other site 701177003301 active site 701177003302 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 701177003303 cytidylate kinase; Provisional; Region: cmk; PRK00023 701177003304 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 701177003305 CMP-binding site; other site 701177003306 The sites determining sugar specificity; other site 701177003307 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 701177003308 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 701177003309 RNA binding site [nucleotide binding]; other site 701177003310 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 701177003311 RNA binding site [nucleotide binding]; other site 701177003312 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 701177003313 RNA binding site [nucleotide binding]; other site 701177003314 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 701177003315 RNA binding site [nucleotide binding]; other site 701177003316 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 701177003317 RNA binding site [nucleotide binding]; other site 701177003318 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 701177003319 IHF dimer interface [polypeptide binding]; other site 701177003320 IHF - DNA interface [nucleotide binding]; other site 701177003321 ComEC family competence protein; Provisional; Region: PRK11539 701177003322 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 701177003323 ComEC/Rec2-related protein; Region: ComEC_N-term; TIGR00360 701177003324 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 701177003325 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 701177003326 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 701177003327 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 701177003328 Walker A/P-loop; other site 701177003329 ATP binding site [chemical binding]; other site 701177003330 Q-loop/lid; other site 701177003331 ABC transporter signature motif; other site 701177003332 Walker B; other site 701177003333 D-loop; other site 701177003334 H-loop/switch region; other site 701177003335 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 701177003336 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 701177003337 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 701177003338 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 701177003339 hypothetical protein; Provisional; Region: PRK11827 701177003340 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 701177003341 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 701177003342 Ligand binding site; other site 701177003343 oligomer interface; other site 701177003344 hypothetical protein; Provisional; Region: PRK10593 701177003345 Uncharacterized conserved protein [Function unknown]; Region: COG1434 701177003346 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 701177003347 putative active site [active] 701177003348 Methyltransferase domain; Region: Methyltransf_31; pfam13847 701177003349 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 701177003350 S-adenosylmethionine binding site [chemical binding]; other site 701177003351 condesin subunit F; Provisional; Region: PRK05260 701177003352 condesin subunit E; Provisional; Region: PRK05256 701177003353 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 701177003354 MukB N-terminal; Region: MukB; pfam04310 701177003355 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 701177003356 murein L,D-transpeptidase; Provisional; Region: PRK10594 701177003357 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 701177003358 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 701177003359 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 701177003360 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 701177003361 Peptidase M15; Region: Peptidase_M15_3; cl01194 701177003362 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 701177003363 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 701177003364 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 701177003365 pyridoxal 5'-phosphate binding site [chemical binding]; other site 701177003366 homodimer interface [polypeptide binding]; other site 701177003367 catalytic residue [active] 701177003368 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 701177003369 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 701177003370 trimer interface [polypeptide binding]; other site 701177003371 eyelet of channel; other site 701177003372 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 701177003373 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 701177003374 putative dimer interface [polypeptide binding]; other site 701177003375 putative anticodon binding site; other site 701177003376 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 701177003377 homodimer interface [polypeptide binding]; other site 701177003378 motif 1; other site 701177003379 motif 2; other site 701177003380 active site 701177003381 motif 3; other site 701177003382 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 701177003383 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 701177003384 active site 701177003385 aminopeptidase N; Provisional; Region: pepN; PRK14015 701177003386 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 701177003387 active site 701177003388 Zn binding site [ion binding]; other site 701177003389 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 701177003390 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 701177003391 Walker A/P-loop; other site 701177003392 ATP binding site [chemical binding]; other site 701177003393 Q-loop/lid; other site 701177003394 ABC transporter signature motif; other site 701177003395 Walker B; other site 701177003396 D-loop; other site 701177003397 H-loop/switch region; other site 701177003398 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 701177003399 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 701177003400 dimer interface [polypeptide binding]; other site 701177003401 conserved gate region; other site 701177003402 putative PBP binding loops; other site 701177003403 ABC-ATPase subunit interface; other site 701177003404 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 701177003405 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 701177003406 active site 701177003407 dimer interface [polypeptide binding]; other site 701177003408 non-prolyl cis peptide bond; other site 701177003409 insertion regions; other site 701177003410 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 701177003411 substrate binding pocket [chemical binding]; other site 701177003412 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 701177003413 membrane-bound complex binding site; other site 701177003414 hinge residues; other site 701177003415 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 701177003416 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 701177003417 Fimbrial protein; Region: Fimbrial; cl01416 701177003418 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 701177003419 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 701177003420 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 701177003421 Fimbrial protein; Region: Fimbrial; cl01416 701177003422 Fimbrial protein; Region: Fimbrial; cl01416 701177003423 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 701177003424 putativi pili assembly chaperone; Provisional; Region: PRK11385 701177003425 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 701177003426 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 701177003427 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 701177003428 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 701177003429 quinone interaction residues [chemical binding]; other site 701177003430 active site 701177003431 catalytic residues [active] 701177003432 FMN binding site [chemical binding]; other site 701177003433 substrate binding site [chemical binding]; other site 701177003434 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 701177003435 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 701177003436 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 701177003437 MOSC domain; Region: MOSC; pfam03473 701177003438 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 701177003439 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 701177003440 catalytic loop [active] 701177003441 iron binding site [ion binding]; other site 701177003442 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 701177003443 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 701177003444 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 701177003445 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 701177003446 S-adenosylmethionine binding site [chemical binding]; other site 701177003447 ABC transporter ATPase component; Reviewed; Region: PRK11147 701177003448 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 701177003449 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 701177003450 Walker A/P-loop; other site 701177003451 Walker A/P-loop; other site 701177003452 ATP binding site [chemical binding]; other site 701177003453 ATP binding site [chemical binding]; other site 701177003454 Q-loop/lid; other site 701177003455 Q-loop/lid; other site 701177003456 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 701177003457 ABC transporter signature motif; other site 701177003458 Walker B; other site 701177003459 D-loop; other site 701177003460 ABC transporter; Region: ABC_tran_2; pfam12848 701177003461 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 701177003462 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 701177003463 Paraquat-inducible protein A; Region: PqiA; pfam04403 701177003464 Paraquat-inducible protein A; Region: PqiA; pfam04403 701177003465 paraquat-inducible protein B; Provisional; Region: PRK10807 701177003466 mce related protein; Region: MCE; pfam02470 701177003467 mce related protein; Region: MCE; pfam02470 701177003468 mce related protein; Region: MCE; pfam02470 701177003469 DASH complex subunit Duo1; Region: DASH_Duo1; pfam08651 701177003470 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 701177003471 Protein of unknown function (DUF330); Region: DUF330; pfam03886 701177003472 ribosome modulation factor; Provisional; Region: PRK14563 701177003473 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 701177003474 active site 1 [active] 701177003475 dimer interface [polypeptide binding]; other site 701177003476 active site 2 [active] 701177003477 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 701177003478 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 701177003479 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 701177003480 outer membrane protein A; Reviewed; Region: PRK10808 701177003481 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 701177003482 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 701177003483 ligand binding site [chemical binding]; other site 701177003484 cell division inhibitor SulA; Region: sula; TIGR00623 701177003485 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 701177003486 TfoX C-terminal domain; Region: TfoX_C; pfam04994 701177003487 TIGR01666 family membrane protein; Region: YCCS 701177003488 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 701177003489 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 701177003490 Predicted membrane protein [Function unknown]; Region: COG3304 701177003491 Domain of unknown function (DUF307); Region: DUF307; pfam03733 701177003492 Domain of unknown function (DUF307); Region: DUF307; pfam03733 701177003493 DNA helicase IV; Provisional; Region: helD; PRK11054 701177003494 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 701177003495 Part of AAA domain; Region: AAA_19; pfam13245 701177003496 Family description; Region: UvrD_C_2; pfam13538 701177003497 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 701177003498 active site 701177003499 dimer interfaces [polypeptide binding]; other site 701177003500 catalytic residues [active] 701177003501 hypothetical protein; Provisional; Region: PRK03641 701177003502 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110 701177003503 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 701177003504 heat shock protein HspQ; Provisional; Region: PRK14129 701177003505 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 701177003506 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 701177003507 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 701177003508 putative RNA binding site [nucleotide binding]; other site 701177003509 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 701177003510 S-adenosylmethionine binding site [chemical binding]; other site 701177003511 Acylphosphatase; Region: Acylphosphatase; cl00551 701177003512 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 701177003513 sulfur transfer protein TusE; Provisional; Region: PRK11508 701177003514 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 701177003515 YccA-like proteins; Region: YccA_like; cd10433 701177003516 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 701177003517 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 701177003518 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 701177003519 hydrogenase 1 large subunit; Provisional; Region: PRK10170 701177003520 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 701177003521 hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171 701177003522 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 701177003523 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 701177003524 putative substrate-binding site; other site 701177003525 nickel binding site [ion binding]; other site 701177003526 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 701177003527 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 701177003528 cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035 701177003529 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 701177003530 cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028 701177003531 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 701177003532 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 701177003533 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 701177003534 catalytic core [active] 701177003535 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 701177003536 cryptic autophosphorylating protein tyrosine kinase Etk; Provisional; Region: PRK09841 701177003537 Chain length determinant protein; Region: Wzz; pfam02706 701177003538 Chain length determinant protein; Region: Wzz; cl15801 701177003539 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 701177003540 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 701177003541 Nucleotide binding site [chemical binding]; other site 701177003542 Low molecular weight phosphatase family; Region: LMWPc; cd00115 701177003543 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 701177003544 active site 701177003545 polysaccharide export protein Wza; Provisional; Region: PRK15078 701177003546 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 701177003547 SLBB domain; Region: SLBB; pfam10531 701177003548 SLBB domain; Region: SLBB; pfam10531 701177003549 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 701177003550 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 701177003551 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 701177003552 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 701177003553 DNA-binding site [nucleotide binding]; DNA binding site 701177003554 RNA-binding motif; other site 701177003555 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 701177003556 DNA-binding site [nucleotide binding]; DNA binding site 701177003557 RNA-binding motif; other site 701177003558 cold shock gene; Provisional; Region: PRK09891 701177003559 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 701177003560 4Fe-4S binding domain; Region: Fer4_5; pfam12801 701177003561 4Fe-4S binding domain; Region: Fer4_5; pfam12801 701177003562 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 701177003563 hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466 701177003564 HAMP domain; Region: HAMP; pfam00672 701177003565 dimerization interface [polypeptide binding]; other site 701177003566 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 701177003567 dimer interface [polypeptide binding]; other site 701177003568 phosphorylation site [posttranslational modification] 701177003569 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 701177003570 ATP binding site [chemical binding]; other site 701177003571 Mg2+ binding site [ion binding]; other site 701177003572 G-X-G motif; other site 701177003573 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 701177003574 active site 701177003575 phosphorylation site [posttranslational modification] 701177003576 intermolecular recognition site; other site 701177003577 dimerization interface [polypeptide binding]; other site 701177003578 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 701177003579 putative binding surface; other site 701177003580 active site 701177003581 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 701177003582 TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306 701177003583 putative ligand binding site [chemical binding]; other site 701177003584 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 701177003585 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 701177003586 active site 701177003587 phosphorylation site [posttranslational modification] 701177003588 intermolecular recognition site; other site 701177003589 dimerization interface [polypeptide binding]; other site 701177003590 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 701177003591 DNA binding site [nucleotide binding] 701177003592 trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032 701177003593 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 701177003594 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 701177003595 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 701177003596 molybdopterin cofactor binding site [chemical binding]; other site 701177003597 substrate binding site [chemical binding]; other site 701177003598 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 701177003599 molybdopterin cofactor binding site; other site 701177003600 chaperone protein TorD; Validated; Region: torD; PRK04976 701177003601 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 701177003602 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 701177003603 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 701177003604 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 701177003605 HSP70 interaction site [polypeptide binding]; other site 701177003606 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 701177003607 substrate binding site [polypeptide binding]; other site 701177003608 dimer interface [polypeptide binding]; other site 701177003609 hypothetical protein; Provisional; Region: PRK09784 701177003610 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 701177003611 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 701177003612 catalytic core [active] 701177003613 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 701177003614 hypothetical protein; Provisional; Region: PRK10174 701177003615 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 701177003616 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 701177003617 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 701177003618 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 701177003619 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 701177003620 putative FMN binding site [chemical binding]; other site 701177003621 pyrimidine utilization protein D; Region: RutD; TIGR03611 701177003622 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 701177003623 homotrimer interaction site [polypeptide binding]; other site 701177003624 putative active site [active] 701177003625 Isochorismatase family; Region: Isochorismatase; pfam00857 701177003626 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 701177003627 catalytic triad [active] 701177003628 conserved cis-peptide bond; other site 701177003629 pyrimidine utilization protein A; Region: RutA; TIGR03612 701177003630 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 701177003631 active site 701177003632 dimer interface [polypeptide binding]; other site 701177003633 non-prolyl cis peptide bond; other site 701177003634 insertion regions; other site 701177003635 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 701177003636 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 701177003637 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 701177003638 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 701177003639 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 701177003640 Predicted transcriptional regulator [Transcription]; Region: COG3905 701177003641 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 701177003642 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 701177003643 Glutamate binding site [chemical binding]; other site 701177003644 NAD binding site [chemical binding]; other site 701177003645 catalytic residues [active] 701177003646 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 701177003647 Na binding site [ion binding]; other site 701177003648 FTR1 family protein; Region: TIGR00145 701177003649 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 701177003650 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 701177003651 Imelysin; Region: Peptidase_M75; pfam09375 701177003652 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 701177003653 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 701177003654 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 701177003655 hypothetical protein; Provisional; Region: PRK10536 701177003656 putative PGA biosynthesis protein; Provisional; Region: pgaD; PRK14585 701177003657 N-glycosyltransferase; Provisional; Region: PRK11204 701177003658 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 701177003659 DXD motif; other site 701177003660 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 701177003661 outer membrane protein PgaA; Provisional; Region: pgaA; PRK10049 701177003662 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 701177003663 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 701177003664 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 701177003665 DNA binding site [nucleotide binding] 701177003666 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 701177003667 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 701177003668 NADP binding site [chemical binding]; other site 701177003669 homodimer interface [polypeptide binding]; other site 701177003670 active site 701177003671 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 701177003672 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 701177003673 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 701177003674 Fimbrial protein; Region: Fimbrial; cl01416 701177003675 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 701177003676 PapC N-terminal domain; Region: PapC_N; pfam13954 701177003677 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 701177003678 PapC C-terminal domain; Region: PapC_C; pfam13953 701177003679 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 701177003680 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 701177003681 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 701177003682 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 701177003683 haemagglutination activity domain; Region: Haemagg_act; pfam05860 701177003684 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 701177003685 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 701177003686 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 701177003687 Phosphopantetheinyl transferase (holo-ACP synthase) [Lipid metabolism]; Region: AcpS; COG0736 701177003688 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 701177003689 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 701177003690 NAD(P) binding site [chemical binding]; other site 701177003691 active site 701177003692 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 701177003693 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 701177003694 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 701177003695 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 701177003696 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 701177003697 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 701177003698 dimer interface [polypeptide binding]; other site 701177003699 active site 701177003700 polyketide beta-ketoacyl:acyl carrier protein synthase; Validated; Region: PRK07103 701177003701 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 701177003702 active site 701177003703 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 701177003704 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 701177003705 active site 701177003706 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 701177003707 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 701177003708 Walker A/P-loop; other site 701177003709 ATP binding site [chemical binding]; other site 701177003710 Q-loop/lid; other site 701177003711 ABC transporter signature motif; other site 701177003712 Walker B; other site 701177003713 D-loop; other site 701177003714 H-loop/switch region; other site 701177003715 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 701177003716 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 701177003717 FtsX-like permease family; Region: FtsX; pfam02687 701177003718 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 701177003719 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 701177003720 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 701177003721 putative ligand binding site [chemical binding]; other site 701177003722 NAD binding site [chemical binding]; other site 701177003723 dimerization interface [polypeptide binding]; other site 701177003724 catalytic site [active] 701177003725 putative hydrolase; Validated; Region: PRK09248 701177003726 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 701177003727 active site 701177003728 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 701177003729 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 701177003730 curli production assembly/transport protein CsgG; Provisional; Region: PRK15184 701177003731 curli assembly protein CsgF; Provisional; Region: PRK10050 701177003732 curli assembly protein CsgE; Provisional; Region: PRK10386 701177003733 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 701177003734 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 701177003735 DNA binding residues [nucleotide binding] 701177003736 dimerization interface [polypeptide binding]; other site 701177003737 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 701177003738 Curlin associated repeat; Region: Curlin_rpt; pfam07012 701177003739 Curlin associated repeat; Region: Curlin_rpt; pfam07012 701177003740 major curlin subunit; Provisional; Region: csgA; PRK10051 701177003741 Curlin associated repeat; Region: Curlin_rpt; pfam07012 701177003742 Curlin associated repeat; Region: Curlin_rpt; pfam07012 701177003743 curli assembly protein CsgC; Provisional; Region: csgC; PRK10102 701177003744 Fimbrial protein; Region: Fimbrial; cl01416 701177003745 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 701177003746 putative ADP-ribose binding site [chemical binding]; other site 701177003747 putative active site [active] 701177003748 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 701177003749 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 701177003750 putative active site [active] 701177003751 catalytic site [active] 701177003752 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 701177003753 putative active site [active] 701177003754 catalytic site [active] 701177003755 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 701177003756 Acyltransferase family; Region: Acyl_transf_3; pfam01757 701177003757 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 701177003758 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349 701177003759 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 701177003760 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 701177003761 Ligand binding site; other site 701177003762 DXD motif; other site 701177003763 lipoprotein; Provisional; Region: PRK10175 701177003764 secY/secA suppressor protein; Provisional; Region: PRK11467 701177003765 drug efflux system protein MdtG; Provisional; Region: PRK09874 701177003766 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177003767 putative substrate translocation pore; other site 701177003768 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 701177003769 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 701177003770 putative acyl-acceptor binding pocket; other site 701177003771 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 701177003772 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 701177003773 active site residue [active] 701177003774 hypothetical protein; Provisional; Region: PRK03757 701177003775 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 701177003776 Protein of unknown function (DUF2770); Region: DUF2770; pfam10968 701177003777 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 701177003778 hydroxyglutarate oxidase; Provisional; Region: PRK11728 701177003779 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 701177003780 DNA damage-inducible protein I; Provisional; Region: PRK10597 701177003781 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 701177003782 active site 701177003783 substrate binding pocket [chemical binding]; other site 701177003784 dimer interface [polypeptide binding]; other site 701177003785 lipoprotein; Provisional; Region: PRK10598 701177003786 glutaredoxin 2; Provisional; Region: PRK10387 701177003787 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 701177003788 C-terminal domain interface [polypeptide binding]; other site 701177003789 GSH binding site (G-site) [chemical binding]; other site 701177003790 catalytic residues [active] 701177003791 putative dimer interface [polypeptide binding]; other site 701177003792 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 701177003793 N-terminal domain interface [polypeptide binding]; other site 701177003794 multidrug resistance protein MdtH; Provisional; Region: PRK11646 701177003795 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177003796 putative substrate translocation pore; other site 701177003797 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 701177003798 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 701177003799 hypothetical protein; Provisional; Region: PRK11239 701177003800 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 701177003801 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 701177003802 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 701177003803 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 701177003804 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 701177003805 MviN-like protein; Region: MVIN; pfam03023 701177003806 flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459 701177003807 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 701177003808 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 701177003809 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 701177003810 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 701177003811 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 701177003812 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 701177003813 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 701177003814 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 701177003815 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 701177003816 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 701177003817 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 701177003818 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 701177003819 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 701177003820 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 701177003821 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 701177003822 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 701177003823 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787 701177003824 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 701177003825 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 701177003826 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 701177003827 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 701177003828 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 701177003829 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 701177003830 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 701177003831 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 701177003832 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 701177003833 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 701177003834 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 701177003835 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 701177003836 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 701177003837 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 701177003838 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 701177003839 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 701177003840 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 701177003841 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 701177003842 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 701177003843 homodimer interface [polypeptide binding]; other site 701177003844 oligonucleotide binding site [chemical binding]; other site 701177003845 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 701177003846 Protein of unknown function (DUF2655); Region: DUF2655; pfam10848 701177003847 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 701177003848 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 701177003849 RNA binding surface [nucleotide binding]; other site 701177003850 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 701177003851 active site 701177003852 Maf-like protein; Region: Maf; pfam02545 701177003853 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 701177003854 active site 701177003855 dimer interface [polypeptide binding]; other site 701177003856 hypothetical protein; Provisional; Region: PRK11193 701177003857 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 701177003858 putative phosphate acyltransferase; Provisional; Region: PRK05331 701177003859 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 701177003860 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 701177003861 dimer interface [polypeptide binding]; other site 701177003862 active site 701177003863 CoA binding pocket [chemical binding]; other site 701177003864 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 701177003865 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 701177003866 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 701177003867 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 701177003868 NAD(P) binding site [chemical binding]; other site 701177003869 homotetramer interface [polypeptide binding]; other site 701177003870 homodimer interface [polypeptide binding]; other site 701177003871 active site 701177003872 acyl carrier protein; Provisional; Region: acpP; PRK00982 701177003873 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 701177003874 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 701177003875 dimer interface [polypeptide binding]; other site 701177003876 active site 701177003877 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 701177003878 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 701177003879 pyridoxal 5'-phosphate binding site [chemical binding]; other site 701177003880 catalytic residue [active] 701177003881 conserved hypothetical protein, YceG family; Region: TIGR00247 701177003882 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 701177003883 dimerization interface [polypeptide binding]; other site 701177003884 thymidylate kinase; Validated; Region: tmk; PRK00698 701177003885 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 701177003886 TMP-binding site; other site 701177003887 ATP-binding site [chemical binding]; other site 701177003888 DNA polymerase III subunit delta'; Validated; Region: PRK07993 701177003889 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 701177003890 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 701177003891 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 701177003892 active site 701177003893 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 701177003894 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 701177003895 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 701177003896 active site turn [active] 701177003897 phosphorylation site [posttranslational modification] 701177003898 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 701177003899 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 701177003900 N-terminal plug; other site 701177003901 ligand-binding site [chemical binding]; other site 701177003902 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 701177003903 nucleotide binding site/active site [active] 701177003904 HIT family signature motif; other site 701177003905 catalytic residue [active] 701177003906 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 701177003907 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 701177003908 putative dimer interface [polypeptide binding]; other site 701177003909 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 701177003910 thiamine kinase; Region: ycfN_thiK; TIGR02721 701177003911 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 701177003912 active site 701177003913 substrate binding site [chemical binding]; other site 701177003914 ATP binding site [chemical binding]; other site 701177003915 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 701177003916 beta-hexosaminidase; Provisional; Region: PRK05337 701177003917 hypothetical protein; Provisional; Region: PRK04940 701177003918 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 701177003919 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 701177003920 hypothetical protein; Provisional; Region: PRK11280 701177003921 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 701177003922 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 701177003923 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 701177003924 L,D-transpeptidase; Provisional; Region: PRK10260 701177003925 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 701177003926 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 701177003927 transcription-repair coupling factor; Provisional; Region: PRK10689 701177003928 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 701177003929 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 701177003930 ATP binding site [chemical binding]; other site 701177003931 putative Mg++ binding site [ion binding]; other site 701177003932 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 701177003933 nucleotide binding region [chemical binding]; other site 701177003934 ATP-binding site [chemical binding]; other site 701177003935 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 701177003936 Predicted membrane protein [Function unknown]; Region: COG4763 701177003937 Acyltransferase family; Region: Acyl_transf_3; pfam01757 701177003938 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 701177003939 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 701177003940 FtsX-like permease family; Region: FtsX; pfam02687 701177003941 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 701177003942 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 701177003943 Walker A/P-loop; other site 701177003944 ATP binding site [chemical binding]; other site 701177003945 Q-loop/lid; other site 701177003946 ABC transporter signature motif; other site 701177003947 Walker B; other site 701177003948 D-loop; other site 701177003949 H-loop/switch region; other site 701177003950 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 701177003951 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 701177003952 FtsX-like permease family; Region: FtsX; pfam02687 701177003953 fructokinase; Reviewed; Region: PRK09557 701177003954 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 701177003955 nucleotide binding site [chemical binding]; other site 701177003956 NAD-dependent deacetylase; Provisional; Region: PRK00481 701177003957 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 701177003958 NAD+ binding site [chemical binding]; other site 701177003959 substrate binding site [chemical binding]; other site 701177003960 Zn binding site [ion binding]; other site 701177003961 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 701177003962 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 701177003963 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 701177003964 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 701177003965 dimer interface [polypeptide binding]; other site 701177003966 conserved gate region; other site 701177003967 putative PBP binding loops; other site 701177003968 ABC-ATPase subunit interface; other site 701177003969 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 701177003970 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 701177003971 dimer interface [polypeptide binding]; other site 701177003972 conserved gate region; other site 701177003973 putative PBP binding loops; other site 701177003974 ABC-ATPase subunit interface; other site 701177003975 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 701177003976 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 701177003977 Walker A/P-loop; other site 701177003978 ATP binding site [chemical binding]; other site 701177003979 Q-loop/lid; other site 701177003980 ABC transporter signature motif; other site 701177003981 Walker B; other site 701177003982 D-loop; other site 701177003983 H-loop/switch region; other site 701177003984 TOBE domain; Region: TOBE_2; pfam08402 701177003985 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 701177003986 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 701177003987 metal binding site [ion binding]; metal-binding site 701177003988 dimer interface [polypeptide binding]; other site 701177003989 Uncharacterized conserved protein [Function unknown]; Region: COG2850 701177003990 Cupin-like domain; Region: Cupin_8; pfam13621 701177003991 integrase; Provisional; Region: PRK09692 701177003992 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 701177003993 active site 701177003994 Int/Topo IB signature motif; other site 701177003995 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 701177003996 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 701177003997 AAA domain; Region: AAA_25; pfam13481 701177003998 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 701177003999 Walker A motif; other site 701177004000 ATP binding site [chemical binding]; other site 701177004001 Walker B motif; other site 701177004002 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 701177004003 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 701177004004 ssDNA binding site [nucleotide binding]; other site 701177004005 dimer interface [polypeptide binding]; other site 701177004006 tetramer (dimer of dimers) interface [polypeptide binding]; other site 701177004007 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 701177004008 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 701177004009 Phage DNA packaging protein Nu1; Region: Phage_Nu1; cl01720 701177004010 sensor protein PhoQ; Provisional; Region: PRK10815 701177004011 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 701177004012 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 701177004013 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 701177004014 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 701177004015 ATP binding site [chemical binding]; other site 701177004016 Mg2+ binding site [ion binding]; other site 701177004017 G-X-G motif; other site 701177004018 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 701177004019 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 701177004020 active site 701177004021 phosphorylation site [posttranslational modification] 701177004022 intermolecular recognition site; other site 701177004023 dimerization interface [polypeptide binding]; other site 701177004024 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 701177004025 DNA binding site [nucleotide binding] 701177004026 adenylosuccinate lyase; Provisional; Region: PRK09285 701177004027 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 701177004028 tetramer interface [polypeptide binding]; other site 701177004029 active site 701177004030 putative lysogenization regulator; Reviewed; Region: PRK00218 701177004031 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 701177004032 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 701177004033 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 701177004034 nudix motif; other site 701177004035 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 701177004036 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 701177004037 probable active site [active] 701177004038 isocitrate dehydrogenase; Validated; Region: PRK07362 701177004039 isocitrate dehydrogenase; Reviewed; Region: PRK07006 701177004040 anti-adapter protein IraM; Provisional; Region: PRK09919 701177004041 Protein of unknown function (DUF1398); Region: DUF1398; pfam07166 701177004042 transcriptional regulator MirA; Provisional; Region: PRK15043 701177004043 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 701177004044 DNA binding residues [nucleotide binding] 701177004045 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 701177004046 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 701177004047 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 701177004048 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 701177004049 hypothetical protein; Provisional; Region: PRK09945 701177004050 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 701177004051 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 701177004052 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 701177004053 Autotransporter beta-domain; Region: Autotransporter; pfam03797 701177004054 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 701177004055 cell division inhibitor MinD; Provisional; Region: PRK10818 701177004056 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 701177004057 Switch I; other site 701177004058 Switch II; other site 701177004059 septum formation inhibitor; Reviewed; Region: minC; PRK03511 701177004060 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 701177004061 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 701177004062 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 701177004063 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 701177004064 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 701177004065 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 701177004066 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 701177004067 hypothetical protein; Provisional; Region: PRK10691 701177004068 hypothetical protein; Provisional; Region: PRK05170 701177004069 hemolysin E; Provisional; Region: hlyE; PRK11376 701177004070 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 701177004071 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 701177004072 Catalytic site [active] 701177004073 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 701177004074 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 701177004075 active site 701177004076 DNA binding site [nucleotide binding] 701177004077 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 701177004078 disulfide bond formation protein B; Provisional; Region: PRK01749 701177004079 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 701177004080 transmembrane helices; other site 701177004081 fatty acid metabolism regulator; Provisional; Region: PRK04984 701177004082 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 701177004083 DNA-binding site [nucleotide binding]; DNA binding site 701177004084 FadR C-terminal domain; Region: FadR_C; pfam07840 701177004085 SpoVR family protein; Provisional; Region: PRK11767 701177004086 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 701177004087 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 701177004088 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 701177004089 alanine racemase; Reviewed; Region: dadX; PRK03646 701177004090 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 701177004091 active site 701177004092 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 701177004093 substrate binding site [chemical binding]; other site 701177004094 catalytic residues [active] 701177004095 dimer interface [polypeptide binding]; other site 701177004096 Leucine rich repeat; Region: LRR_8; pfam13855 701177004097 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 701177004098 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 701177004099 TrkA-C domain; Region: TrkA_C; pfam02080 701177004100 Transporter associated domain; Region: CorC_HlyC; smart01091 701177004101 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 701177004102 dimer interface [polypeptide binding]; other site 701177004103 catalytic triad [active] 701177004104 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 701177004105 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 701177004106 N-acetyl-D-glucosamine binding site [chemical binding]; other site 701177004107 catalytic residue [active] 701177004108 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 701177004109 Flagellar regulator YcgR; Region: YcgR; pfam07317 701177004110 PilZ domain; Region: PilZ; pfam07238 701177004111 hypothetical protein; Provisional; Region: PRK10457 701177004112 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 701177004113 N-terminal plug; other site 701177004114 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 701177004115 ligand-binding site [chemical binding]; other site 701177004116 molybdenum transport protein ModD; Provisional; Region: PRK06096 701177004117 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 701177004118 dimerization interface [polypeptide binding]; other site 701177004119 active site 701177004120 Methyltransferase domain; Region: Methyltransf_31; pfam13847 701177004121 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 701177004122 S-adenosylmethionine binding site [chemical binding]; other site 701177004123 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 701177004124 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 701177004125 Walker A/P-loop; other site 701177004126 ATP binding site [chemical binding]; other site 701177004127 Q-loop/lid; other site 701177004128 ABC transporter signature motif; other site 701177004129 Walker B; other site 701177004130 D-loop; other site 701177004131 H-loop/switch region; other site 701177004132 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 701177004133 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 701177004134 ABC-ATPase subunit interface; other site 701177004135 dimer interface [polypeptide binding]; other site 701177004136 putative PBP binding regions; other site 701177004137 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 701177004138 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 701177004139 putative metal binding site [ion binding]; other site 701177004140 trehalase; Provisional; Region: treA; PRK13271 701177004141 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 701177004142 Trehalase; Region: Trehalase; cl17346 701177004143 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3412 701177004144 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 701177004145 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 701177004146 dimerization domain swap beta strand [polypeptide binding]; other site 701177004147 regulatory protein interface [polypeptide binding]; other site 701177004148 active site 701177004149 regulatory phosphorylation site [posttranslational modification]; other site 701177004150 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 701177004151 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 701177004152 dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005 701177004153 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 701177004154 Dak1 domain; Region: Dak1; pfam02733 701177004155 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 701177004156 PAS domain; Region: PAS; smart00091 701177004157 putative active site [active] 701177004158 heme pocket [chemical binding]; other site 701177004159 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 701177004160 Walker A motif; other site 701177004161 ATP binding site [chemical binding]; other site 701177004162 Walker B motif; other site 701177004163 arginine finger; other site 701177004164 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 701177004165 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 701177004166 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 701177004167 Autotransporter beta-domain; Region: Autotransporter; pfam03797 701177004168 GTP-binding protein YchF; Reviewed; Region: PRK09601 701177004169 YchF GTPase; Region: YchF; cd01900 701177004170 G1 box; other site 701177004171 GTP/Mg2+ binding site [chemical binding]; other site 701177004172 Switch I region; other site 701177004173 G2 box; other site 701177004174 Switch II region; other site 701177004175 G3 box; other site 701177004176 G4 box; other site 701177004177 G5 box; other site 701177004178 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 701177004179 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 701177004180 putative active site [active] 701177004181 catalytic residue [active] 701177004182 hypothetical protein; Provisional; Region: PRK10692 701177004183 putative transporter; Provisional; Region: PRK11660 701177004184 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 701177004185 Sulfate transporter family; Region: Sulfate_transp; pfam00916 701177004186 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 701177004187 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 701177004188 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 701177004189 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 701177004190 active site 701177004191 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 701177004192 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 701177004193 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 701177004194 outer membrane lipoprotein LolB; Region: lolB; TIGR00548 701177004195 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 701177004196 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 701177004197 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 701177004198 tRNA; other site 701177004199 putative tRNA binding site [nucleotide binding]; other site 701177004200 putative NADP binding site [chemical binding]; other site 701177004201 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 701177004202 peptide chain release factor 1; Validated; Region: prfA; PRK00591 701177004203 This domain is found in peptide chain release factors; Region: PCRF; smart00937 701177004204 RF-1 domain; Region: RF-1; pfam00472 701177004205 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 701177004206 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 701177004207 hypothetical protein; Provisional; Region: PRK10278 701177004208 hypothetical protein; Provisional; Region: PRK10941 701177004209 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 701177004210 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 701177004211 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 701177004212 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 701177004213 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 701177004214 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 701177004215 cation transport regulator; Reviewed; Region: chaB; PRK09582 701177004216 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 701177004217 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 701177004218 putative active site pocket [active] 701177004219 dimerization interface [polypeptide binding]; other site 701177004220 putative catalytic residue [active] 701177004221 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 701177004222 putative invasin; Provisional; Region: PRK10177 701177004223 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 701177004224 transcriptional regulator NarL; Provisional; Region: PRK10651 701177004225 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 701177004226 active site 701177004227 phosphorylation site [posttranslational modification] 701177004228 intermolecular recognition site; other site 701177004229 dimerization interface [polypeptide binding]; other site 701177004230 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 701177004231 DNA binding residues [nucleotide binding] 701177004232 dimerization interface [polypeptide binding]; other site 701177004233 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 701177004234 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 701177004235 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 701177004236 dimerization interface [polypeptide binding]; other site 701177004237 Histidine kinase; Region: HisKA_3; pfam07730 701177004238 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 701177004239 ATP binding site [chemical binding]; other site 701177004240 Mg2+ binding site [ion binding]; other site 701177004241 G-X-G motif; other site 701177004242 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 701177004243 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 701177004244 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 701177004245 [4Fe-4S] binding site [ion binding]; other site 701177004246 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 701177004247 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 701177004248 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 701177004249 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 701177004250 molybdopterin cofactor binding site; other site 701177004251 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 701177004252 4Fe-4S binding domain; Region: Fer4; cl02805 701177004253 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 701177004254 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 701177004255 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 701177004256 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 701177004257 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 701177004258 putative active site [active] 701177004259 putative substrate binding site [chemical binding]; other site 701177004260 putative cosubstrate binding site; other site 701177004261 catalytic site [active] 701177004262 SEC-C motif; Region: SEC-C; pfam02810 701177004263 hypothetical protein; Provisional; Region: PRK04233 701177004264 hypothetical protein; Provisional; Region: PRK10279 701177004265 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 701177004266 active site 701177004267 nucleophile elbow; other site 701177004268 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 701177004269 active site 701177004270 response regulator of RpoS; Provisional; Region: PRK10693 701177004271 phosphorylation site [posttranslational modification] 701177004272 intermolecular recognition site; other site 701177004273 dimerization interface [polypeptide binding]; other site 701177004274 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 701177004275 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 701177004276 active site 701177004277 tetramer interface; other site 701177004278 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 701177004279 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 701177004280 thymidine kinase; Provisional; Region: PRK04296 701177004281 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 701177004282 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 701177004283 putative catalytic cysteine [active] 701177004284 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 701177004285 putative active site [active] 701177004286 metal binding site [ion binding]; metal-binding site 701177004287 hypothetical protein; Provisional; Region: PRK11111 701177004288 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 701177004289 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 701177004290 peptide binding site [polypeptide binding]; other site 701177004291 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 701177004292 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 701177004293 dimer interface [polypeptide binding]; other site 701177004294 conserved gate region; other site 701177004295 putative PBP binding loops; other site 701177004296 ABC-ATPase subunit interface; other site 701177004297 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 701177004298 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 701177004299 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 701177004300 dimer interface [polypeptide binding]; other site 701177004301 conserved gate region; other site 701177004302 putative PBP binding loops; other site 701177004303 ABC-ATPase subunit interface; other site 701177004304 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 701177004305 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 701177004306 Walker A/P-loop; other site 701177004307 ATP binding site [chemical binding]; other site 701177004308 Q-loop/lid; other site 701177004309 ABC transporter signature motif; other site 701177004310 Walker B; other site 701177004311 D-loop; other site 701177004312 H-loop/switch region; other site 701177004313 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 701177004314 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 701177004315 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 701177004316 Walker A/P-loop; other site 701177004317 ATP binding site [chemical binding]; other site 701177004318 Q-loop/lid; other site 701177004319 ABC transporter signature motif; other site 701177004320 Walker B; other site 701177004321 D-loop; other site 701177004322 H-loop/switch region; other site 701177004323 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 701177004324 dsDNA-mimic protein; Reviewed; Region: PRK05094 701177004325 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 701177004326 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 701177004327 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 701177004328 putative active site [active] 701177004329 catalytic site [active] 701177004330 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 701177004331 putative active site [active] 701177004332 catalytic site [active] 701177004333 voltage-gated potassium channel; Provisional; Region: PRK10537 701177004334 Ion channel; Region: Ion_trans_2; pfam07885 701177004335 TrkA-N domain; Region: TrkA_N; pfam02254 701177004336 YciI-like protein; Reviewed; Region: PRK11370 701177004337 transport protein TonB; Provisional; Region: PRK10819 701177004338 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 701177004339 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 701177004340 intracellular septation protein A; Reviewed; Region: PRK00259 701177004341 hypothetical protein; Provisional; Region: PRK02868 701177004342 outer membrane protein W; Provisional; Region: PRK10959 701177004343 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 701177004344 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 701177004345 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 701177004346 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 701177004347 dimer interface [polypeptide binding]; other site 701177004348 active site 701177004349 Int/Topo IB signature motif; other site 701177004350 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 701177004351 active site 701177004352 catalytic site [active] 701177004353 substrate binding site [chemical binding]; other site 701177004354 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 701177004355 DicB protein; Region: DicB; pfam05358 701177004356 transcriptional repressor DicA; Reviewed; Region: PRK09706 701177004357 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 701177004358 sequence-specific DNA binding site [nucleotide binding]; other site 701177004359 salt bridge; other site 701177004360 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 701177004361 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 701177004362 Pyocin large subunit [General function prediction only]; Region: COG5529 701177004363 Helix-turn-helix domain; Region: HTH_36; pfam13730 701177004364 primosomal protein DnaI; Provisional; Region: PRK02854 701177004365 Protein of unknown function (DUF1627); Region: DUF1627; pfam07789 701177004366 Accessory colonization factor AcfC, contains ABC-type periplasmic domain [General function prediction only]; Region: AcfC; COG4588 701177004367 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 701177004368 Hok/gef family; Region: HOK_GEF; pfam01848 701177004369 adenylosuccinate lyase; Provisional; Region: PRK09285 701177004370 Protein of unknown function (DUF968); Region: DUF968; pfam06147 701177004371 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 701177004372 Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323 701177004373 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 701177004374 Domain of unknown function (DUF303); Region: DUF303; pfam03629 701177004375 Lysis protein S; Region: Lysis_S; pfam04971 701177004376 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 701177004377 catalytic residues [active] 701177004378 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 701177004379 PerC transcriptional activator; Region: PerC; pfam06069 701177004380 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 701177004381 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 701177004382 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 701177004383 active site 701177004384 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 701177004385 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 701177004386 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 701177004387 Transposase; Region: HTH_Tnp_1; cl17663 701177004388 Integrase core domain; Region: rve; pfam00665 701177004389 DDE domain; Region: DDE_Tnp_IS240; pfam13610 701177004390 Integrase core domain; Region: rve_3; pfam13683 701177004391 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 701177004392 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 701177004393 Phage capsid family; Region: Phage_capsid; pfam05065 701177004394 Bacteriophage head-tail adaptor [General function prediction only]; Region: COG5614 701177004395 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 701177004396 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 701177004397 Immunoglobulin I-set domain; Region: I-set; pfam07679 701177004398 Immunoglobulin domain; Region: Ig_2; pfam13895 701177004399 Phage tail assembly chaperone; Region: Phage_TAC; pfam06222 701177004400 Protein of unknown function (DUF4035); Region: DUF4035; pfam13227 701177004401 Phage-related minor tail protein [Function unknown]; Region: COG5281 701177004402 tape measure domain; Region: tape_meas_nterm; TIGR02675 701177004403 Tail length tape measure protein; Region: Phage_HK97_TLTM; pfam06120 701177004404 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 701177004405 Phage-related protein [Function unknown]; Region: COG4718 701177004406 Phage-related protein [Function unknown]; Region: gp18; COG4672 701177004407 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 701177004408 MPN+ (JAMM) motif; other site 701177004409 Zinc-binding site [ion binding]; other site 701177004410 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 701177004411 NlpC/P60 family; Region: NLPC_P60; cl17555 701177004412 Phage-related protein, tail component [Function unknown]; Region: COG4723 701177004413 Phage-related protein, tail component [Function unknown]; Region: COG4733 701177004414 Putative phage tail protein; Region: Phage-tail_3; pfam13550 701177004415 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 701177004416 Interdomain contacts; other site 701177004417 Cytokine receptor motif; other site 701177004418 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 701177004419 Fibronectin type III protein; Region: DUF3672; pfam12421 701177004420 putative transposase OrfB; Reviewed; Region: PHA02517 701177004421 HTH-like domain; Region: HTH_21; pfam13276 701177004422 Integrase core domain; Region: rve; pfam00665 701177004423 Integrase core domain; Region: rve_3; pfam13683 701177004424 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 701177004425 Transposase; Region: HTH_Tnp_1; cl17663 701177004426 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 701177004427 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 701177004428 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 701177004429 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 701177004430 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 701177004431 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 701177004432 dimer interface [polypeptide binding]; other site 701177004433 active site 701177004434 Int/Topo IB signature motif; other site 701177004435 hypothetical protein; Provisional; Region: PHA03031 701177004436 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 701177004437 MULE transposase domain; Region: MULE; pfam10551 701177004438 OmpW family; Region: OmpW; cl17427 701177004439 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 701177004440 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 701177004441 dimerization interface [polypeptide binding]; other site 701177004442 metal binding site [ion binding]; metal-binding site 701177004443 General stress protein [General function prediction only]; Region: GsiB; COG3729 701177004444 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 701177004445 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 701177004446 substrate binding site [chemical binding]; other site 701177004447 active site 701177004448 catalytic residues [active] 701177004449 heterodimer interface [polypeptide binding]; other site 701177004450 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 701177004451 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 701177004452 pyridoxal 5'-phosphate binding site [chemical binding]; other site 701177004453 catalytic residue [active] 701177004454 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 701177004455 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 701177004456 active site 701177004457 ribulose/triose binding site [chemical binding]; other site 701177004458 phosphate binding site [ion binding]; other site 701177004459 substrate (anthranilate) binding pocket [chemical binding]; other site 701177004460 product (indole) binding pocket [chemical binding]; other site 701177004461 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 701177004462 active site 701177004463 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 701177004464 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 701177004465 glutamine binding [chemical binding]; other site 701177004466 catalytic triad [active] 701177004467 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 701177004468 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 701177004469 anthranilate synthase component I; Provisional; Region: PRK13564 701177004470 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 701177004471 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 701177004472 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 701177004473 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 701177004474 active site 701177004475 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 701177004476 hypothetical protein; Provisional; Region: PRK11630 701177004477 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 701177004478 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 701177004479 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 701177004480 RNA binding surface [nucleotide binding]; other site 701177004481 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 701177004482 probable active site [active] 701177004483 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 701177004484 cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase; Validated; Region: PRK05986 701177004485 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 701177004486 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 701177004487 NADP binding site [chemical binding]; other site 701177004488 homodimer interface [polypeptide binding]; other site 701177004489 active site 701177004490 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 701177004491 putative inner membrane peptidase; Provisional; Region: PRK11778 701177004492 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 701177004493 tandem repeat interface [polypeptide binding]; other site 701177004494 oligomer interface [polypeptide binding]; other site 701177004495 active site residues [active] 701177004496 hypothetical protein; Provisional; Region: PRK11037 701177004497 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 701177004498 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 701177004499 active site 701177004500 interdomain interaction site; other site 701177004501 putative metal-binding site [ion binding]; other site 701177004502 nucleotide binding site [chemical binding]; other site 701177004503 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 701177004504 domain I; other site 701177004505 DNA binding groove [nucleotide binding] 701177004506 phosphate binding site [ion binding]; other site 701177004507 domain II; other site 701177004508 domain III; other site 701177004509 nucleotide binding site [chemical binding]; other site 701177004510 catalytic site [active] 701177004511 domain IV; other site 701177004512 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 701177004513 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 701177004514 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 701177004515 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 701177004516 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 701177004517 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 701177004518 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 701177004519 substrate binding site [chemical binding]; other site 701177004520 putative dimerization interface [polypeptide binding]; other site 701177004521 aconitate hydratase; Validated; Region: PRK09277 701177004522 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 701177004523 substrate binding site [chemical binding]; other site 701177004524 ligand binding site [chemical binding]; other site 701177004525 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 701177004526 substrate binding site [chemical binding]; other site 701177004527 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 701177004528 dimerization interface [polypeptide binding]; other site 701177004529 active site 701177004530 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 701177004531 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 701177004532 active site 701177004533 Predicted membrane protein [Function unknown]; Region: COG3771 701177004534 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 701177004535 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 701177004536 TPR motif; other site 701177004537 binding surface 701177004538 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 701177004539 binding surface 701177004540 TPR motif; other site 701177004541 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 701177004542 active site 701177004543 dimer interface [polypeptide binding]; other site 701177004544 translation initiation factor Sui1; Validated; Region: PRK06824 701177004545 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 701177004546 putative rRNA binding site [nucleotide binding]; other site 701177004547 lipoprotein; Provisional; Region: PRK10540 701177004548 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 701177004549 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 701177004550 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 701177004551 hypothetical protein; Provisional; Region: PRK13658 701177004552 RNase II stability modulator; Provisional; Region: PRK10060 701177004553 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 701177004554 putative active site [active] 701177004555 heme pocket [chemical binding]; other site 701177004556 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 701177004557 metal binding site [ion binding]; metal-binding site 701177004558 active site 701177004559 I-site; other site 701177004560 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 701177004561 exoribonuclease II; Provisional; Region: PRK05054 701177004562 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 701177004563 RNB domain; Region: RNB; pfam00773 701177004564 S1 RNA binding domain; Region: S1; pfam00575 701177004565 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 701177004566 Uncharacterized conserved protein [Function unknown]; Region: COG2128 701177004567 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 701177004568 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 701177004569 NAD binding site [chemical binding]; other site 701177004570 homotetramer interface [polypeptide binding]; other site 701177004571 homodimer interface [polypeptide binding]; other site 701177004572 substrate binding site [chemical binding]; other site 701177004573 active site 701177004574 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 701177004575 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 701177004576 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 701177004577 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 701177004578 HlyD family secretion protein; Region: HlyD_3; pfam13437 701177004579 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 701177004580 Protein export membrane protein; Region: SecD_SecF; cl14618 701177004581 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 701177004582 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 701177004583 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177004584 putative substrate translocation pore; other site 701177004585 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 701177004586 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 701177004587 Walker A/P-loop; other site 701177004588 ATP binding site [chemical binding]; other site 701177004589 Q-loop/lid; other site 701177004590 ABC transporter signature motif; other site 701177004591 Walker B; other site 701177004592 D-loop; other site 701177004593 H-loop/switch region; other site 701177004594 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 701177004595 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 701177004596 Walker A/P-loop; other site 701177004597 ATP binding site [chemical binding]; other site 701177004598 Q-loop/lid; other site 701177004599 ABC transporter signature motif; other site 701177004600 Walker B; other site 701177004601 D-loop; other site 701177004602 H-loop/switch region; other site 701177004603 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 701177004604 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 701177004605 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 701177004606 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 701177004607 dimer interface [polypeptide binding]; other site 701177004608 conserved gate region; other site 701177004609 putative PBP binding loops; other site 701177004610 ABC-ATPase subunit interface; other site 701177004611 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 701177004612 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 701177004613 dimer interface [polypeptide binding]; other site 701177004614 conserved gate region; other site 701177004615 putative PBP binding loops; other site 701177004616 ABC-ATPase subunit interface; other site 701177004617 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 701177004618 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 701177004619 peptide binding site [polypeptide binding]; other site 701177004620 Protein of unknown function (DUF2543); Region: DUF2543; pfam10820 701177004621 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 701177004622 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 701177004623 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 701177004624 gamma-glutamyl-gamma-aminobutyrate hydrolase; Provisional; Region: puuD; PRK11366 701177004625 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 701177004626 catalytic triad [active] 701177004627 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 701177004628 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 701177004629 non-specific DNA binding site [nucleotide binding]; other site 701177004630 salt bridge; other site 701177004631 sequence-specific DNA binding site [nucleotide binding]; other site 701177004632 Cupin domain; Region: Cupin_2; pfam07883 701177004633 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 701177004634 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 701177004635 NAD(P) binding site [chemical binding]; other site 701177004636 catalytic residues [active] 701177004637 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 701177004638 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 701177004639 4-aminobutyrate transaminase; Provisional; Region: PRK09792 701177004640 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 701177004641 inhibitor-cofactor binding pocket; inhibition site 701177004642 pyridoxal 5'-phosphate binding site [chemical binding]; other site 701177004643 catalytic residue [active] 701177004644 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 701177004645 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 701177004646 Walker A motif; other site 701177004647 ATP binding site [chemical binding]; other site 701177004648 Walker B motif; other site 701177004649 arginine finger; other site 701177004650 phage shock protein PspA; Provisional; Region: PRK10698 701177004651 phage shock protein B; Provisional; Region: pspB; PRK09458 701177004652 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 701177004653 phage shock protein C; Region: phageshock_pspC; TIGR02978 701177004654 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 701177004655 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 701177004656 active site residue [active] 701177004657 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 701177004658 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 701177004659 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 701177004660 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 701177004661 dimer interface [polypeptide binding]; other site 701177004662 conserved gate region; other site 701177004663 putative PBP binding loops; other site 701177004664 ABC-ATPase subunit interface; other site 701177004665 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 701177004666 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 701177004667 dimer interface [polypeptide binding]; other site 701177004668 conserved gate region; other site 701177004669 putative PBP binding loops; other site 701177004670 ABC-ATPase subunit interface; other site 701177004671 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 701177004672 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 701177004673 putative NAD(P) binding site [chemical binding]; other site 701177004674 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 701177004675 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 701177004676 Metal-binding active site; metal-binding site 701177004677 AP (apurinic/apyrimidinic) site pocket; other site 701177004678 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 701177004679 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 701177004680 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 701177004681 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 701177004682 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 701177004683 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 701177004684 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 701177004685 beta-phosphoglucomutase; Region: bPGM; TIGR01990 701177004686 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 701177004687 motif II; other site 701177004688 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 701177004689 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 701177004690 Walker A/P-loop; other site 701177004691 ATP binding site [chemical binding]; other site 701177004692 Q-loop/lid; other site 701177004693 ABC transporter signature motif; other site 701177004694 Walker B; other site 701177004695 D-loop; other site 701177004696 H-loop/switch region; other site 701177004697 TOBE domain; Region: TOBE_2; pfam08402 701177004698 Outer membrane protein G (OmpG); Region: Porin_OmpG; pfam09381 701177004699 Transcriptional regulators [Transcription]; Region: PurR; COG1609 701177004700 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 701177004701 DNA binding site [nucleotide binding] 701177004702 domain linker motif; other site 701177004703 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 701177004704 putative dimerization interface [polypeptide binding]; other site 701177004705 putative ligand binding site [chemical binding]; other site 701177004706 Predicted ATPase [General function prediction only]; Region: COG3106 701177004707 hypothetical protein; Provisional; Region: PRK05415 701177004708 TIGR01620 family protein; Region: hyp_HI0043 701177004709 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 701177004710 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 701177004711 putative aromatic amino acid binding site; other site 701177004712 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 701177004713 Walker A motif; other site 701177004714 ATP binding site [chemical binding]; other site 701177004715 Walker B motif; other site 701177004716 arginine finger; other site 701177004717 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 701177004718 dimer interface [polypeptide binding]; other site 701177004719 catalytic triad [active] 701177004720 peroxidatic and resolving cysteines [active] 701177004721 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 701177004722 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 701177004723 active site 701177004724 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 701177004725 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 701177004726 putative active site [active] 701177004727 Zn binding site [ion binding]; other site 701177004728 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 701177004729 NADH(P)-binding; Region: NAD_binding_10; pfam13460 701177004730 putative NAD(P) binding site [chemical binding]; other site 701177004731 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 701177004732 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 701177004733 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 701177004734 Transcriptional regulator [Transcription]; Region: LysR; COG0583 701177004735 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 701177004736 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 701177004737 putative effector binding pocket; other site 701177004738 putative dimerization interface [polypeptide binding]; other site 701177004739 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 701177004740 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 701177004741 peptide binding site [polypeptide binding]; other site 701177004742 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 701177004743 Mechanosensitive ion channel; Region: MS_channel; pfam00924 701177004744 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 701177004745 universal stress protein UspE; Provisional; Region: PRK11175 701177004746 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 701177004747 Ligand Binding Site [chemical binding]; other site 701177004748 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 701177004749 Ligand Binding Site [chemical binding]; other site 701177004750 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 701177004751 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 701177004752 ligand binding site [chemical binding]; other site 701177004753 flexible hinge region; other site 701177004754 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 701177004755 putative switch regulator; other site 701177004756 non-specific DNA interactions [nucleotide binding]; other site 701177004757 DNA binding site [nucleotide binding] 701177004758 sequence specific DNA binding site [nucleotide binding]; other site 701177004759 putative cAMP binding site [chemical binding]; other site 701177004760 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 701177004761 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 701177004762 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 701177004763 DNA binding site [nucleotide binding] 701177004764 active site 701177004765 putative aminobenzoyl-glutamate transporter; Provisional; Region: abgT; PRK11339 701177004766 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 701177004767 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 701177004768 amidohydrolase; Region: amidohydrolases; TIGR01891 701177004769 putative metal binding site [ion binding]; other site 701177004770 M20 Peptidases Aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase from bacteria and archaea; Region: M20_Acy1_IAAspH_bact; cd05665 701177004771 amidohydrolase; Region: amidohydrolases; TIGR01891 701177004772 putative metal binding site [ion binding]; other site 701177004773 dimer interface [polypeptide binding]; other site 701177004774 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 701177004775 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 701177004776 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 701177004777 putative substrate binding pocket [chemical binding]; other site 701177004778 putative dimerization interface [polypeptide binding]; other site 701177004779 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 701177004780 Smr domain; Region: Smr; pfam01713 701177004781 PAS domain S-box; Region: sensory_box; TIGR00229 701177004782 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 701177004783 putative active site [active] 701177004784 heme pocket [chemical binding]; other site 701177004785 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 701177004786 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 701177004787 metal binding site [ion binding]; metal-binding site 701177004788 active site 701177004789 I-site; other site 701177004790 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 701177004791 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 701177004792 Cl binding site [ion binding]; other site 701177004793 oligomer interface [polypeptide binding]; other site 701177004794 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 701177004795 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 701177004796 ATP binding site [chemical binding]; other site 701177004797 Mg++ binding site [ion binding]; other site 701177004798 motif III; other site 701177004799 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 701177004800 nucleotide binding region [chemical binding]; other site 701177004801 ATP-binding site [chemical binding]; other site 701177004802 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 701177004803 putative RNA binding site [nucleotide binding]; other site 701177004804 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 701177004805 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 701177004806 Ligand Binding Site [chemical binding]; other site 701177004807 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 701177004808 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 701177004809 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 701177004810 Int/Topo IB signature motif; other site 701177004811 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 701177004812 hypothetical protein; Provisional; Region: PRK09750 701177004813 restriction alleviation and modification protein; Reviewed; Region: lar; PRK09710 701177004814 recombination and repair protein RecT; Reviewed; Region: recT; PRK09846 701177004815 exonuclease VIII; Reviewed; Region: PRK09709 701177004816 Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630 701177004817 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 701177004818 hypothetical protein; Reviewed; Region: PRK09790 701177004819 FtsZ inhibitor protein; Reviewed; Region: kil; PRK11354 701177004820 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 701177004821 Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197 701177004822 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 701177004823 primosomal protein DnaI; Provisional; Region: PRK02854 701177004824 putative replication protein; Provisional; Region: PRK12377 701177004825 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 701177004826 Walker A motif; other site 701177004827 ATP binding site [chemical binding]; other site 701177004828 Protein of unknown function (DUF1627); Region: DUF1627; pfam07789 701177004829 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 701177004830 Protein of unknown function (DUF551); Region: DUF551; pfam04448 701177004831 Hok/gef family; Region: HOK_GEF; pfam01848 701177004832 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 701177004833 Protein of unknown function (DUF1133); Region: DUF1133; pfam06576 701177004834 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 701177004835 Domain of unknown function (DUF303); Region: DUF303; pfam03629 701177004836 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 701177004837 Protein of unknown function (DUF826); Region: DUF826; pfam05696 701177004838 Lysis protein S; Region: Lysis_S; pfam04971 701177004839 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 701177004840 catalytic residues [active] 701177004841 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 701177004842 ORF11CD3 domain; Region: ORF11CD3; pfam10549 701177004843 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 701177004844 Protein of unknown function (DUF1441); Region: DUF1441; pfam07278 701177004845 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 701177004846 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 701177004847 Clp protease; Region: CLP_protease; pfam00574 701177004848 oligomer interface [polypeptide binding]; other site 701177004849 active site residues [active] 701177004850 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 701177004851 Uncharacterized conserved protein [Function unknown]; Region: COG5471 701177004852 ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; pfam13856 701177004853 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 701177004854 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 701177004855 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 701177004856 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 701177004857 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894 701177004858 phage tail assembly protein T; Region: phage_lam_T; TIGR01715 701177004859 Phage-related minor tail protein [Function unknown]; Region: COG5281 701177004860 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 701177004861 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 701177004862 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 701177004863 Phage-related protein [Function unknown]; Region: COG4718 701177004864 Phage-related protein [Function unknown]; Region: gp18; COG4672 701177004865 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 701177004866 MPN+ (JAMM) motif; other site 701177004867 Zinc-binding site [ion binding]; other site 701177004868 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 701177004869 NlpC/P60 family; Region: NLPC_P60; cl17555 701177004870 Phage-related protein, tail component [Function unknown]; Region: COG4723 701177004871 Phage-related protein, tail component [Function unknown]; Region: COG4733 701177004872 Putative phage tail protein; Region: Phage-tail_3; pfam13550 701177004873 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 701177004874 Interdomain contacts; other site 701177004875 Cytokine receptor motif; other site 701177004876 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 701177004877 Fibronectin type III protein; Region: DUF3672; pfam12421 701177004878 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 701177004879 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 701177004880 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 701177004881 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 701177004882 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 701177004883 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 701177004884 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 701177004885 Ligand Binding Site [chemical binding]; other site 701177004886 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 701177004887 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 701177004888 trimer interface [polypeptide binding]; other site 701177004889 eyelet of channel; other site 701177004890 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 701177004891 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 701177004892 dimer interface [polypeptide binding]; other site 701177004893 PYR/PP interface [polypeptide binding]; other site 701177004894 TPP binding site [chemical binding]; other site 701177004895 substrate binding site [chemical binding]; other site 701177004896 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 701177004897 Domain of unknown function; Region: EKR; smart00890 701177004898 4Fe-4S binding domain; Region: Fer4_6; pfam12837 701177004899 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 701177004900 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 701177004901 TPP-binding site [chemical binding]; other site 701177004902 dimer interface [polypeptide binding]; other site 701177004903 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 701177004904 Domain of unknown function (DUF333); Region: DUF333; pfam03891 701177004905 heat-inducible protein; Provisional; Region: PRK10449 701177004906 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 701177004907 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 701177004908 putative ligand binding site [chemical binding]; other site 701177004909 putative NAD binding site [chemical binding]; other site 701177004910 catalytic site [active] 701177004911 hypothetical protein; Provisional; Region: PRK10695 701177004912 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 701177004913 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 701177004914 baseplate hub subunit and tail lysozyme; Provisional; Region: 5; PHA02596 701177004915 Autotransporter beta-domain; Region: Autotransporter; pfam03797 701177004916 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 701177004917 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 701177004918 active site 701177004919 catalytic tetrad [active] 701177004920 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 701177004921 Protein of unknown function (DUF2773); Region: DUF2773; pfam10971 701177004922 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 701177004923 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 701177004924 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 701177004925 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 701177004926 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 701177004927 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 701177004928 S-adenosylmethionine binding site [chemical binding]; other site 701177004929 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 701177004930 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 701177004931 active site 701177004932 Dual specificity phosphatase, catalytic domain; Region: DSPc; smart00195 701177004933 active site 701177004934 catalytic residues [active] 701177004935 azoreductase; Reviewed; Region: PRK00170 701177004936 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 701177004937 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 701177004938 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 701177004939 ATP binding site [chemical binding]; other site 701177004940 putative Mg++ binding site [ion binding]; other site 701177004941 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 701177004942 nucleotide binding region [chemical binding]; other site 701177004943 ATP-binding site [chemical binding]; other site 701177004944 Helicase associated domain (HA2); Region: HA2; pfam04408 701177004945 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 701177004946 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 701177004947 Uncharacterized conserved protein [Function unknown]; Region: COG1434 701177004948 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 701177004949 putative active site [active] 701177004950 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 701177004951 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 701177004952 NAD binding site [chemical binding]; other site 701177004953 catalytic residues [active] 701177004954 substrate binding site [chemical binding]; other site 701177004955 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 701177004956 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 701177004957 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 701177004958 cytochrome b561; Provisional; Region: PRK11513 701177004959 hypothetical protein; Provisional; Region: PRK10040 701177004960 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 701177004961 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 701177004962 dimer interface [polypeptide binding]; other site 701177004963 ligand binding site [chemical binding]; other site 701177004964 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 701177004965 dimerization interface [polypeptide binding]; other site 701177004966 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 701177004967 dimer interface [polypeptide binding]; other site 701177004968 putative CheW interface [polypeptide binding]; other site 701177004969 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 701177004970 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 701177004971 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 701177004972 dimerization interface [polypeptide binding]; other site 701177004973 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 701177004974 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 701177004975 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 701177004976 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 701177004977 hypothetical protein; Provisional; Region: PRK11415 701177004978 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 701177004979 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 701177004980 Coenzyme A binding pocket [chemical binding]; other site 701177004981 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 701177004982 putative trimer interface [polypeptide binding]; other site 701177004983 putative CoA binding site [chemical binding]; other site 701177004984 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 701177004985 putative trimer interface [polypeptide binding]; other site 701177004986 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 701177004987 putative CoA binding site [chemical binding]; other site 701177004988 putative trimer interface [polypeptide binding]; other site 701177004989 putative CoA binding site [chemical binding]; other site 701177004990 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 701177004991 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 701177004992 gating phenylalanine in ion channel; other site 701177004993 tellurite resistance protein TehB; Provisional; Region: PRK11207 701177004994 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 701177004995 S-adenosylmethionine binding site [chemical binding]; other site 701177004996 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 701177004997 benzoate transporter; Region: benE; TIGR00843 701177004998 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 701177004999 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 701177005000 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 701177005001 non-specific DNA binding site [nucleotide binding]; other site 701177005002 salt bridge; other site 701177005003 sequence-specific DNA binding site [nucleotide binding]; other site 701177005004 Cupin domain; Region: Cupin_2; pfam07883 701177005005 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 701177005006 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 701177005007 Peptidase family U32; Region: Peptidase_U32; pfam01136 701177005008 Collagenase; Region: DUF3656; pfam12392 701177005009 Protein of unknown function (DUF2554); Region: DUF2554; pfam10829 701177005010 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 701177005011 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 701177005012 sequence-specific DNA binding site [nucleotide binding]; other site 701177005013 salt bridge; other site 701177005014 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 701177005015 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 701177005016 DNA-binding site [nucleotide binding]; DNA binding site 701177005017 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 701177005018 pyridoxal 5'-phosphate binding site [chemical binding]; other site 701177005019 homodimer interface [polypeptide binding]; other site 701177005020 catalytic residue [active] 701177005021 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 701177005022 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 701177005023 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 701177005024 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 701177005025 Walker A/P-loop; other site 701177005026 ATP binding site [chemical binding]; other site 701177005027 Q-loop/lid; other site 701177005028 ABC transporter signature motif; other site 701177005029 Walker B; other site 701177005030 D-loop; other site 701177005031 H-loop/switch region; other site 701177005032 TOBE domain; Region: TOBE_2; pfam08402 701177005033 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 701177005034 dimer interface [polypeptide binding]; other site 701177005035 conserved gate region; other site 701177005036 putative PBP binding loops; other site 701177005037 ABC-ATPase subunit interface; other site 701177005038 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 701177005039 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 701177005040 ABC-ATPase subunit interface; other site 701177005041 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 701177005042 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 701177005043 tetrameric interface [polypeptide binding]; other site 701177005044 NAD binding site [chemical binding]; other site 701177005045 catalytic residues [active] 701177005046 substrate binding site [chemical binding]; other site 701177005047 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 701177005048 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 701177005049 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 701177005050 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 701177005051 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 701177005052 Coenzyme A binding pocket [chemical binding]; other site 701177005053 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 701177005054 Prostaglandin dehydrogenases; Region: PGDH; cd05288 701177005055 NAD(P) binding site [chemical binding]; other site 701177005056 substrate binding site [chemical binding]; other site 701177005057 dimer interface [polypeptide binding]; other site 701177005058 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 701177005059 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 701177005060 DNA-binding site [nucleotide binding]; DNA binding site 701177005061 FCD domain; Region: FCD; pfam07729 701177005062 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 701177005063 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 701177005064 N-terminal plug; other site 701177005065 ligand-binding site [chemical binding]; other site 701177005066 PQQ-like domain; Region: PQQ_2; pfam13360 701177005067 L-asparagine permease; Provisional; Region: PRK15049 701177005068 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 701177005069 C-terminal domain interface [polypeptide binding]; other site 701177005070 GSH binding site (G-site) [chemical binding]; other site 701177005071 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 701177005072 dimer interface [polypeptide binding]; other site 701177005073 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 701177005074 dimer interface [polypeptide binding]; other site 701177005075 N-terminal domain interface [polypeptide binding]; other site 701177005076 substrate binding pocket (H-site) [chemical binding]; other site 701177005077 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 701177005078 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 701177005079 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 701177005080 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 701177005081 4-oxalocrotonate tautomerase; Provisional; Region: PRK01271 701177005082 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 701177005083 N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047 701177005084 hypothetical protein; Provisional; Region: PRK10281 701177005085 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 701177005086 nitrate reductase 2 subunit delta; Provisional; Region: PRK15054 701177005087 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 701177005088 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 701177005089 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 701177005090 [4Fe-4S] binding site [ion binding]; other site 701177005091 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 701177005092 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 701177005093 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 701177005094 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 701177005095 molybdopterin cofactor binding site; other site 701177005096 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 701177005097 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 701177005098 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 701177005099 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 701177005100 trimer interface [polypeptide binding]; other site 701177005101 eyelet of channel; other site 701177005102 aromatic amino acid exporter; Provisional; Region: PRK11689 701177005103 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 701177005104 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 701177005105 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 701177005106 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 701177005107 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 701177005108 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 701177005109 non-specific DNA binding site [nucleotide binding]; other site 701177005110 salt bridge; other site 701177005111 sequence-specific DNA binding site [nucleotide binding]; other site 701177005112 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 701177005113 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 701177005114 NAD binding site [chemical binding]; other site 701177005115 substrate binding site [chemical binding]; other site 701177005116 catalytic Zn binding site [ion binding]; other site 701177005117 tetramer interface [polypeptide binding]; other site 701177005118 structural Zn binding site [ion binding]; other site 701177005119 malate dehydrogenase; Provisional; Region: PRK13529 701177005120 Malic enzyme, N-terminal domain; Region: malic; pfam00390 701177005121 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 701177005122 NAD(P) binding site [chemical binding]; other site 701177005123 30S ribosomal subunit S22; Reviewed; Region: rpsV; PRK10057 701177005124 Putative biofilm-dependent modulation protein; Region: BDM; cl11581 701177005125 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 701177005126 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 701177005127 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 701177005128 Walker A/P-loop; other site 701177005129 ATP binding site [chemical binding]; other site 701177005130 Q-loop/lid; other site 701177005131 ABC transporter signature motif; other site 701177005132 Walker B; other site 701177005133 D-loop; other site 701177005134 H-loop/switch region; other site 701177005135 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 701177005136 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 701177005137 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 701177005138 Walker A/P-loop; other site 701177005139 ATP binding site [chemical binding]; other site 701177005140 Q-loop/lid; other site 701177005141 ABC transporter signature motif; other site 701177005142 Walker B; other site 701177005143 D-loop; other site 701177005144 H-loop/switch region; other site 701177005145 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 701177005146 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 701177005147 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 701177005148 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 701177005149 dimer interface [polypeptide binding]; other site 701177005150 conserved gate region; other site 701177005151 putative PBP binding loops; other site 701177005152 ABC-ATPase subunit interface; other site 701177005153 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 701177005154 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 701177005155 dimer interface [polypeptide binding]; other site 701177005156 conserved gate region; other site 701177005157 putative PBP binding loops; other site 701177005158 ABC-ATPase subunit interface; other site 701177005159 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 701177005160 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 701177005161 D-alanyl-D-alanine dipeptidase; Provisional; Region: PRK10178 701177005162 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 701177005163 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 701177005164 putative active site [active] 701177005165 heme pocket [chemical binding]; other site 701177005166 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 701177005167 putative active site [active] 701177005168 heme pocket [chemical binding]; other site 701177005169 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 701177005170 metal binding site [ion binding]; metal-binding site 701177005171 active site 701177005172 I-site; other site 701177005173 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 701177005174 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 701177005175 heme-binding site [chemical binding]; other site 701177005176 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 701177005177 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 701177005178 metal binding site [ion binding]; metal-binding site 701177005179 active site 701177005180 I-site; other site 701177005181 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 701177005182 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 701177005183 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 701177005184 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 701177005185 pyridoxal 5'-phosphate binding site [chemical binding]; other site 701177005186 catalytic residue [active] 701177005187 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 701177005188 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 701177005189 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 701177005190 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 701177005191 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 701177005192 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 701177005193 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 701177005194 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 701177005195 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 701177005196 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 701177005197 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 701177005198 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 701177005199 FeS/SAM binding site; other site 701177005200 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 701177005201 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 701177005202 Sulfatase; Region: Sulfatase; pfam00884 701177005203 transcriptional regulator YdeO; Provisional; Region: PRK09940 701177005204 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 701177005205 putative oxidoreductase; Provisional; Region: PRK09939 701177005206 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 701177005207 putative molybdopterin cofactor binding site [chemical binding]; other site 701177005208 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 701177005209 putative molybdopterin cofactor binding site; other site 701177005210 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 701177005211 mannosyl binding site [chemical binding]; other site 701177005212 Fimbrial protein; Region: Fimbrial; pfam00419 701177005213 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 701177005214 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 701177005215 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 701177005216 PapC N-terminal domain; Region: PapC_N; pfam13954 701177005217 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 701177005218 PapC C-terminal domain; Region: PapC_C; pfam13953 701177005219 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 701177005220 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 701177005221 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 701177005222 Fimbrial protein; Region: Fimbrial; cl01416 701177005223 Helix-turn-helix domain; Region: HTH_18; pfam12833 701177005224 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 701177005225 HipA N-terminal domain; Region: Couple_hipA; pfam13657 701177005226 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 701177005227 HipA-like N-terminal domain; Region: HipA_N; pfam07805 701177005228 HipA-like C-terminal domain; Region: HipA_C; pfam07804 701177005229 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 701177005230 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 701177005231 non-specific DNA binding site [nucleotide binding]; other site 701177005232 salt bridge; other site 701177005233 sequence-specific DNA binding site [nucleotide binding]; other site 701177005234 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 701177005235 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 701177005236 Autotransporter beta-domain; Region: Autotransporter; pfam03797 701177005237 putative lipoprotein; Provisional; Region: PRK09707 701177005238 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 701177005239 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 701177005240 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 701177005241 putative N- and C-terminal domain interface [polypeptide binding]; other site 701177005242 putative active site [active] 701177005243 putative MgATP binding site [chemical binding]; other site 701177005244 catalytic site [active] 701177005245 metal binding site [ion binding]; metal-binding site 701177005246 putative carbohydrate binding site [chemical binding]; other site 701177005247 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 701177005248 transcriptional regulator LsrR; Provisional; Region: PRK15418 701177005249 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 701177005250 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 701177005251 autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439 701177005252 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 701177005253 Walker A/P-loop; other site 701177005254 ATP binding site [chemical binding]; other site 701177005255 Q-loop/lid; other site 701177005256 ABC transporter signature motif; other site 701177005257 Walker B; other site 701177005258 D-loop; other site 701177005259 H-loop/switch region; other site 701177005260 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 701177005261 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 701177005262 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 701177005263 TM-ABC transporter signature motif; other site 701177005264 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 701177005265 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 701177005266 TM-ABC transporter signature motif; other site 701177005267 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 701177005268 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 701177005269 ligand binding site [chemical binding]; other site 701177005270 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 701177005271 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 701177005272 putative active site; other site 701177005273 catalytic residue [active] 701177005274 autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486 701177005275 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 701177005276 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 701177005277 S-adenosylmethionine binding site [chemical binding]; other site 701177005278 Predicted membrane protein [Function unknown]; Region: COG3781 701177005279 altronate oxidoreductase; Provisional; Region: PRK03643 701177005280 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 701177005281 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 701177005282 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 701177005283 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 701177005284 metal binding site [ion binding]; metal-binding site 701177005285 active site 701177005286 I-site; other site 701177005287 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 701177005288 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 701177005289 glutaminase; Provisional; Region: PRK00971 701177005290 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 701177005291 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 701177005292 NAD(P) binding site [chemical binding]; other site 701177005293 catalytic residues [active] 701177005294 Transcriptional regulator [Transcription]; Region: LysR; COG0583 701177005295 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 701177005296 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 701177005297 putative dimerization interface [polypeptide binding]; other site 701177005298 putative arabinose transporter; Provisional; Region: PRK03545 701177005299 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177005300 putative substrate translocation pore; other site 701177005301 inner membrane protein; Provisional; Region: PRK10995 701177005302 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 701177005303 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 701177005304 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 701177005305 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 701177005306 hypothetical protein; Provisional; Region: PRK10106 701177005307 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 701177005308 EamA-like transporter family; Region: EamA; pfam00892 701177005309 EamA-like transporter family; Region: EamA; pfam00892 701177005310 putative transporter; Provisional; Region: PRK10054 701177005311 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177005312 putative substrate translocation pore; other site 701177005313 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 701177005314 active site residue [active] 701177005315 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 701177005316 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 701177005317 conserved cys residue [active] 701177005318 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 701177005319 diguanylate cyclase; Provisional; Region: PRK09894 701177005320 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 701177005321 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 701177005322 metal binding site [ion binding]; metal-binding site 701177005323 active site 701177005324 I-site; other site 701177005325 hypothetical protein; Provisional; Region: PRK10053 701177005326 hypothetical protein; Validated; Region: PRK03657 701177005327 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 701177005328 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 701177005329 active site 701177005330 Zn binding site [ion binding]; other site 701177005331 malonic semialdehyde reductase; Provisional; Region: PRK10538 701177005332 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 701177005333 putative NAD(P) binding site [chemical binding]; other site 701177005334 homodimer interface [polypeptide binding]; other site 701177005335 homotetramer interface [polypeptide binding]; other site 701177005336 active site 701177005337 Transcriptional regulators [Transcription]; Region: GntR; COG1802 701177005338 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 701177005339 DNA-binding site [nucleotide binding]; DNA binding site 701177005340 FCD domain; Region: FCD; pfam07729 701177005341 putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318 701177005342 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 701177005343 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 701177005344 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 701177005345 metabolite-proton symporter; Region: 2A0106; TIGR00883 701177005346 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177005347 putative substrate translocation pore; other site 701177005348 DinI-like family; Region: DinI; pfam06183 701177005349 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 701177005350 MULE transposase domain; Region: MULE; pfam10551 701177005351 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 701177005352 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 701177005353 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 701177005354 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 701177005355 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 701177005356 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 701177005357 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 701177005358 Fibronectin type III protein; Region: DUF3672; pfam12421 701177005359 Phage-related protein, tail component [Function unknown]; Region: COG4733 701177005360 Putative phage tail protein; Region: Phage-tail_3; pfam13550 701177005361 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 701177005362 Fibronectin type III protein; Region: DUF3672; pfam12421 701177005363 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 701177005364 MPN+ (JAMM) motif; other site 701177005365 Zinc-binding site [ion binding]; other site 701177005366 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 701177005367 NlpC/P60 family; Region: NLPC_P60; cl17555 701177005368 Phage-related protein [Function unknown]; Region: gp18; COG4672 701177005369 Phage-related protein [Function unknown]; Region: COG4718 701177005370 Phage-related minor tail protein [Function unknown]; Region: COG5281 701177005371 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 701177005372 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 701177005373 Minor tail protein T; Region: Phage_tail_T; cl05636 701177005374 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894 701177005375 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 701177005376 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 701177005377 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 701177005378 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 701177005379 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 701177005380 DNA packaging protein FI; Region: Packaging_FI; pfam14000 701177005381 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 701177005382 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 701177005383 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 701177005384 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 701177005385 tandem repeat interface [polypeptide binding]; other site 701177005386 oligomer interface [polypeptide binding]; other site 701177005387 active site residues [active] 701177005388 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 701177005389 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 701177005390 gpW; Region: gpW; pfam02831 701177005391 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 701177005392 Phage DNA packaging protein, Nu1 subunit of terminase [DNA replication, recombination, and repair]; Region: COG4220 701177005393 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 701177005394 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 701177005395 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 701177005396 ORF11CD3 domain; Region: ORF11CD3; pfam10549 701177005397 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 701177005398 catalytic residues [active] 701177005399 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 701177005400 Lysis protein S; Region: Lysis_S; pfam04971 701177005401 Protein of unknown function (DUF826); Region: DUF826; pfam05696 701177005402 Protein of unknown function (DUF1378); Region: DUF1378; pfam07125 701177005403 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 701177005404 Domain of unknown function (DUF303); Region: DUF303; pfam03629 701177005405 Antitermination protein; Region: Antiterm; pfam03589 701177005406 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 701177005407 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 701177005408 Protein of unknown function (DUF968); Region: DUF968; pfam06147 701177005409 Hok/gef family; Region: HOK_GEF; pfam01848 701177005410 Protein of unknown function (DUF551); Region: DUF551; pfam04448 701177005411 Protein of unknown function (DUF4014); Region: DUF4014; pfam13198 701177005412 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 701177005413 primosomal protein DnaI; Provisional; Region: PRK02854 701177005414 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 701177005415 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 701177005416 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 701177005417 non-specific DNA binding site [nucleotide binding]; other site 701177005418 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 701177005419 salt bridge; other site 701177005420 sequence-specific DNA binding site [nucleotide binding]; other site 701177005421 Domain of unknown function (DUF3527); Region: DUF3527; pfam12043 701177005422 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 701177005423 Catalytic site [active] 701177005424 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 701177005425 DicB protein; Region: DicB; pfam05358 701177005426 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 701177005427 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 701177005428 active site 701177005429 substrate binding site [chemical binding]; other site 701177005430 catalytic site [active] 701177005431 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 701177005432 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 701177005433 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 701177005434 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 701177005435 Int/Topo IB signature motif; other site 701177005436 putative oxidoreductase; Provisional; Region: PRK10083 701177005437 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 701177005438 putative NAD(P) binding site [chemical binding]; other site 701177005439 catalytic Zn binding site [ion binding]; other site 701177005440 structural Zn binding site [ion binding]; other site 701177005441 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 701177005442 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 701177005443 putative active site pocket [active] 701177005444 putative metal binding site [ion binding]; other site 701177005445 hypothetical protein; Provisional; Region: PRK02237 701177005446 hypothetical protein; Provisional; Region: PRK13659 701177005447 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 701177005448 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 701177005449 Coenzyme A binding pocket [chemical binding]; other site 701177005450 Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788 701177005451 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 701177005452 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 701177005453 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 701177005454 putative [Fe4-S4] binding site [ion binding]; other site 701177005455 putative molybdopterin cofactor binding site [chemical binding]; other site 701177005456 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 701177005457 putative molybdopterin cofactor binding site; other site 701177005458 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 701177005459 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 701177005460 putative [Fe4-S4] binding site [ion binding]; other site 701177005461 putative molybdopterin cofactor binding site [chemical binding]; other site 701177005462 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 701177005463 putative molybdopterin cofactor binding site; other site 701177005464 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 701177005465 4Fe-4S binding domain; Region: Fer4; cl02805 701177005466 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 701177005467 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 701177005468 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 701177005469 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 701177005470 Cl- selectivity filter; other site 701177005471 Cl- binding residues [ion binding]; other site 701177005472 pore gating glutamate residue; other site 701177005473 dimer interface [polypeptide binding]; other site 701177005474 putative dithiobiotin synthetase; Provisional; Region: PRK12374 701177005475 AAA domain; Region: AAA_26; pfam13500 701177005476 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 701177005477 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 701177005478 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 701177005479 nucleotide binding site [chemical binding]; other site 701177005480 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 701177005481 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 701177005482 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 701177005483 dimerization interface [polypeptide binding]; other site 701177005484 substrate binding pocket [chemical binding]; other site 701177005485 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 701177005486 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177005487 putative substrate translocation pore; other site 701177005488 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 701177005489 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 701177005490 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 701177005491 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 701177005492 Domain of unknown function DUF20; Region: UPF0118; pfam01594 701177005493 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 701177005494 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 701177005495 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 701177005496 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 701177005497 ligand binding site [chemical binding]; other site 701177005498 homodimer interface [polypeptide binding]; other site 701177005499 NAD(P) binding site [chemical binding]; other site 701177005500 trimer interface B [polypeptide binding]; other site 701177005501 trimer interface A [polypeptide binding]; other site 701177005502 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 701177005503 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 701177005504 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 701177005505 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 701177005506 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 701177005507 Spore germination protein; Region: Spore_permease; cl17796 701177005508 dihydromonapterin reductase; Provisional; Region: PRK06483 701177005509 pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357 701177005510 NADP binding site [chemical binding]; other site 701177005511 substrate binding pocket [chemical binding]; other site 701177005512 active site 701177005513 GlpM protein; Region: GlpM; pfam06942 701177005514 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 701177005515 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 701177005516 active site 701177005517 phosphorylation site [posttranslational modification] 701177005518 intermolecular recognition site; other site 701177005519 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 701177005520 DNA binding site [nucleotide binding] 701177005521 sensor protein RstB; Provisional; Region: PRK10604 701177005522 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 701177005523 dimerization interface [polypeptide binding]; other site 701177005524 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 701177005525 dimer interface [polypeptide binding]; other site 701177005526 phosphorylation site [posttranslational modification] 701177005527 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 701177005528 ATP binding site [chemical binding]; other site 701177005529 Mg2+ binding site [ion binding]; other site 701177005530 G-X-G motif; other site 701177005531 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 701177005532 fumarate hydratase; Reviewed; Region: fumC; PRK00485 701177005533 Class II fumarases; Region: Fumarase_classII; cd01362 701177005534 active site 701177005535 tetramer interface [polypeptide binding]; other site 701177005536 fumarate hydratase; Provisional; Region: PRK15389 701177005537 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 701177005538 Fumarase C-terminus; Region: Fumerase_C; pfam05683 701177005539 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 701177005540 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 701177005541 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 701177005542 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 701177005543 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 701177005544 glucuronide transporter; Provisional; Region: PRK09848 701177005545 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 701177005546 beta-D-glucuronidase; Provisional; Region: PRK10150 701177005547 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 701177005548 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 701177005549 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 701177005550 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 701177005551 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 701177005552 7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113 701177005553 7 alpha-hydroxysteroid dehydrogenase (7 alpha-HSDH), classical (c) SDRs; Region: 7_alpha_HSDH_SDR_c; cd05365 701177005554 NAD binding site [chemical binding]; other site 701177005555 substrate binding site [chemical binding]; other site 701177005556 homotetramer interface [polypeptide binding]; other site 701177005557 homodimer interface [polypeptide binding]; other site 701177005558 active site 701177005559 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 701177005560 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 701177005561 DNA binding site [nucleotide binding] 701177005562 domain linker motif; other site 701177005563 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 701177005564 putative dimerization interface [polypeptide binding]; other site 701177005565 putative ligand binding site [chemical binding]; other site 701177005566 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 701177005567 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 701177005568 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 701177005569 active site turn [active] 701177005570 phosphorylation site [posttranslational modification] 701177005571 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 701177005572 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 701177005573 pyridoxal 5'-phosphate binding site [chemical binding]; other site 701177005574 homodimer interface [polypeptide binding]; other site 701177005575 catalytic residue [active] 701177005576 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 701177005577 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 701177005578 active site 701177005579 purine riboside binding site [chemical binding]; other site 701177005580 putative oxidoreductase; Provisional; Region: PRK11579 701177005581 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 701177005582 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 701177005583 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 701177005584 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 701177005585 electron transport complex protein RsxA; Provisional; Region: PRK05151 701177005586 electron transport complex protein RnfB; Provisional; Region: PRK05113 701177005587 Putative Fe-S cluster; Region: FeS; pfam04060 701177005588 4Fe-4S binding domain; Region: Fer4; pfam00037 701177005589 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 701177005590 SLBB domain; Region: SLBB; pfam10531 701177005591 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 701177005592 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 701177005593 electron transport complex protein RnfG; Validated; Region: PRK01908 701177005594 electron transport complex RsxE subunit; Provisional; Region: PRK12405 701177005595 endonuclease III; Provisional; Region: PRK10702 701177005596 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 701177005597 minor groove reading motif; other site 701177005598 helix-hairpin-helix signature motif; other site 701177005599 substrate binding pocket [chemical binding]; other site 701177005600 active site 701177005601 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 701177005602 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 701177005603 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177005604 putative substrate translocation pore; other site 701177005605 POT family; Region: PTR2; pfam00854 701177005606 glutathionine S-transferase; Provisional; Region: PRK10542 701177005607 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 701177005608 C-terminal domain interface [polypeptide binding]; other site 701177005609 GSH binding site (G-site) [chemical binding]; other site 701177005610 dimer interface [polypeptide binding]; other site 701177005611 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 701177005612 N-terminal domain interface [polypeptide binding]; other site 701177005613 dimer interface [polypeptide binding]; other site 701177005614 substrate binding pocket (H-site) [chemical binding]; other site 701177005615 pyridoxamine kinase; Validated; Region: PRK05756 701177005616 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 701177005617 dimer interface [polypeptide binding]; other site 701177005618 pyridoxal binding site [chemical binding]; other site 701177005619 ATP binding site [chemical binding]; other site 701177005620 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 701177005621 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 701177005622 active site 701177005623 HIGH motif; other site 701177005624 dimer interface [polypeptide binding]; other site 701177005625 KMSKS motif; other site 701177005626 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 701177005627 RNA binding surface [nucleotide binding]; other site 701177005628 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 701177005629 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 701177005630 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 701177005631 lysozyme inhibitor; Provisional; Region: PRK11372 701177005632 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 701177005633 Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702 701177005634 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 701177005635 transcriptional regulator SlyA; Provisional; Region: PRK03573 701177005636 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 701177005637 Protein of unknown function (DUF1656); Region: DUF1656; cl11658 701177005638 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 701177005639 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 701177005640 HlyD family secretion protein; Region: HlyD_3; pfam13437 701177005641 Fusaric acid resistance protein family; Region: FUSC; pfam04632 701177005642 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 701177005643 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 701177005644 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 701177005645 E-class dimer interface [polypeptide binding]; other site 701177005646 P-class dimer interface [polypeptide binding]; other site 701177005647 active site 701177005648 Cu2+ binding site [ion binding]; other site 701177005649 Zn2+ binding site [ion binding]; other site 701177005650 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 701177005651 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 701177005652 active site 701177005653 catalytic tetrad [active] 701177005654 Predicted Fe-S protein [General function prediction only]; Region: COG3313 701177005655 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 701177005656 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 701177005657 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 701177005658 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 701177005659 FMN binding site [chemical binding]; other site 701177005660 active site 701177005661 substrate binding site [chemical binding]; other site 701177005662 catalytic residue [active] 701177005663 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 701177005664 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 701177005665 dimer interface [polypeptide binding]; other site 701177005666 active site 701177005667 metal binding site [ion binding]; metal-binding site 701177005668 glutathione binding site [chemical binding]; other site 701177005669 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 701177005670 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 701177005671 dimer interface [polypeptide binding]; other site 701177005672 catalytic site [active] 701177005673 putative active site [active] 701177005674 putative substrate binding site [chemical binding]; other site 701177005675 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 701177005676 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 701177005677 ATP binding site [chemical binding]; other site 701177005678 putative Mg++ binding site [ion binding]; other site 701177005679 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 701177005680 nucleotide binding region [chemical binding]; other site 701177005681 ATP-binding site [chemical binding]; other site 701177005682 DEAD/H associated; Region: DEAD_assoc; pfam08494 701177005683 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 701177005684 putative GSH binding site [chemical binding]; other site 701177005685 catalytic residues [active] 701177005686 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 701177005687 NlpC/P60 family; Region: NLPC_P60; pfam00877 701177005688 superoxide dismutase; Provisional; Region: PRK10543 701177005689 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 701177005690 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 701177005691 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177005692 Major Facilitator Superfamily; Region: MFS_1; pfam07690 701177005693 putative substrate translocation pore; other site 701177005694 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 701177005695 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 701177005696 DNA binding site [nucleotide binding] 701177005697 domain linker motif; other site 701177005698 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 701177005699 dimerization interface [polypeptide binding]; other site 701177005700 ligand binding site [chemical binding]; other site 701177005701 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 701177005702 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 701177005703 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 701177005704 dimerization interface [polypeptide binding]; other site 701177005705 putative transporter; Provisional; Region: PRK11043 701177005706 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177005707 putative substrate translocation pore; other site 701177005708 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 701177005709 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 701177005710 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 701177005711 S-adenosylmethionine binding site [chemical binding]; other site 701177005712 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 701177005713 Lumazine binding domain; Region: Lum_binding; pfam00677 701177005714 Lumazine binding domain; Region: Lum_binding; pfam00677 701177005715 multidrug efflux protein; Reviewed; Region: PRK01766 701177005716 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 701177005717 cation binding site [ion binding]; other site 701177005718 hypothetical protein; Provisional; Region: PRK09945 701177005719 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 701177005720 putative monooxygenase; Provisional; Region: PRK11118 701177005721 hypothetical protein; Provisional; Region: PRK09897 701177005722 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 701177005723 hypothetical protein; Provisional; Region: PRK09946 701177005724 thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006 701177005725 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 701177005726 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 701177005727 hypothetical protein; Provisional; Region: PRK09947 701177005728 putative oxidoreductase; Provisional; Region: PRK09849 701177005729 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 701177005730 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 701177005731 hypothetical protein; Provisional; Region: PRK09898 701177005732 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 701177005733 hypothetical protein; Provisional; Region: PRK10292 701177005734 pyruvate kinase; Provisional; Region: PRK09206 701177005735 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 701177005736 active site 701177005737 domain interfaces; other site 701177005738 murein lipoprotein; Provisional; Region: PRK15396 701177005739 L,D-transpeptidase; Provisional; Region: PRK10190 701177005740 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 701177005741 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 701177005742 cysteine desufuration protein SufE; Provisional; Region: PRK09296 701177005743 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 701177005744 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 701177005745 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 701177005746 catalytic residue [active] 701177005747 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 701177005748 FeS assembly protein SufD; Region: sufD; TIGR01981 701177005749 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 701177005750 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 701177005751 Walker A/P-loop; other site 701177005752 ATP binding site [chemical binding]; other site 701177005753 Q-loop/lid; other site 701177005754 ABC transporter signature motif; other site 701177005755 Walker B; other site 701177005756 D-loop; other site 701177005757 H-loop/switch region; other site 701177005758 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 701177005759 putative ABC transporter; Region: ycf24; CHL00085 701177005760 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 701177005761 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 701177005762 CoenzymeA binding site [chemical binding]; other site 701177005763 subunit interaction site [polypeptide binding]; other site 701177005764 PHB binding site; other site 701177005765 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 701177005766 FAD binding domain; Region: FAD_binding_4; pfam01565 701177005767 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 701177005768 putative inner membrane protein; Provisional; Region: PRK10983 701177005769 Domain of unknown function DUF20; Region: UPF0118; pfam01594 701177005770 Domain of unknown function (DUF1870); Region: DUF1870; pfam08965 701177005771 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177005772 Major Facilitator Superfamily; Region: MFS_1; pfam07690 701177005773 putative substrate translocation pore; other site 701177005774 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177005775 putative substrate translocation pore; other site 701177005776 quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749 701177005777 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 701177005778 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 701177005779 shikimate binding site; other site 701177005780 NAD(P) binding site [chemical binding]; other site 701177005781 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 701177005782 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 701177005783 active site 701177005784 catalytic residue [active] 701177005785 dimer interface [polypeptide binding]; other site 701177005786 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 701177005787 Coenzyme A transferase; Region: CoA_trans; smart00882 701177005788 Coenzyme A transferase; Region: CoA_trans; cl17247 701177005789 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 701177005790 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 701177005791 active site 701177005792 Cupin domain; Region: Cupin_2; pfam07883 701177005793 Winged helix DNA-binding domain (DUF1495); Region: DUF1495; cl01336 701177005794 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 701177005795 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 701177005796 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 701177005797 Ligand binding site [chemical binding]; other site 701177005798 Electron transfer flavoprotein domain; Region: ETF; pfam01012 701177005799 electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916 701177005800 Electron transfer flavoprotein domain; Region: ETF; smart00893 701177005801 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 701177005802 oxidoreductase; Provisional; Region: PRK10015 701177005803 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 701177005804 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 701177005805 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 701177005806 acyl-activating enzyme (AAE) consensus motif; other site 701177005807 putative AMP binding site [chemical binding]; other site 701177005808 putative active site [active] 701177005809 putative CoA binding site [chemical binding]; other site 701177005810 phosphoenolpyruvate synthase; Validated; Region: PRK06464 701177005811 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 701177005812 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 701177005813 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 701177005814 PEP synthetase regulatory protein; Provisional; Region: PRK05339 701177005815 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 701177005816 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 701177005817 Hemin uptake protein [Inorganic ion transport and metabolism]; Region: HemP; COG4256 701177005818 Uncharacterized conserved protein [Function unknown]; Region: COG0397 701177005819 hypothetical protein; Validated; Region: PRK00029 701177005820 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 701177005821 NlpC/P60 family; Region: NLPC_P60; pfam00877 701177005822 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 701177005823 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 701177005824 Walker A/P-loop; other site 701177005825 ATP binding site [chemical binding]; other site 701177005826 Q-loop/lid; other site 701177005827 ABC transporter signature motif; other site 701177005828 Walker B; other site 701177005829 D-loop; other site 701177005830 H-loop/switch region; other site 701177005831 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 701177005832 catalytic residues [active] 701177005833 dimer interface [polypeptide binding]; other site 701177005834 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 701177005835 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 701177005836 ABC-ATPase subunit interface; other site 701177005837 dimer interface [polypeptide binding]; other site 701177005838 putative PBP binding regions; other site 701177005839 integrase; Provisional; Region: int; PHA02601 701177005840 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 701177005841 active site 701177005842 DNA binding site [nucleotide binding] 701177005843 Int/Topo IB signature motif; other site 701177005844 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 701177005845 non-specific DNA binding site [nucleotide binding]; other site 701177005846 salt bridge; other site 701177005847 sequence-specific DNA binding site [nucleotide binding]; other site 701177005848 Transcriptional regulators [Transcription]; Region: MarR; COG1846 701177005849 MarR family; Region: MarR_2; pfam12802 701177005850 Ash protein family; Region: Phage_ASH; pfam10554 701177005851 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 701177005852 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 701177005853 Mg binding site [ion binding]; other site 701177005854 nucleotide binding site [chemical binding]; other site 701177005855 putative protofilament interface [polypeptide binding]; other site 701177005856 Plasmid stability protein; Region: Plasmid_stab_B; pfam10784 701177005857 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 701177005858 Phage-related protein [Function unknown]; Region: COG4695; cl01923 701177005859 Phage portal protein; Region: Phage_portal; pfam04860 701177005860 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 701177005861 terminase ATPase subunit; Provisional; Region: P; PHA02535 701177005862 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 701177005863 Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947 701177005864 terminase endonuclease subunit; Provisional; Region: M; PHA02537 701177005865 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 701177005866 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 701177005867 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 701177005868 Phage holin family (Lysis protein S); Region: Phage_holin_3; cl04938 701177005869 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 701177005870 Protein of unknown function (DUF2570); Region: DUF2570; pfam10828 701177005871 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 701177005872 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 701177005873 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 701177005874 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 701177005875 Baseplate J-like protein; Region: Baseplate_J; cl01294 701177005876 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 701177005877 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 701177005878 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 701177005879 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 701177005880 Phage Tail Collar Domain; Region: Collar; pfam07484 701177005881 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 701177005882 Phage Tail Collar Domain; Region: Collar; pfam07484 701177005883 Phage Tail Collar Domain; Region: Collar; pfam07484 701177005884 multiple promoter invertase; Provisional; Region: mpi; PRK13413 701177005885 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 701177005886 catalytic residues [active] 701177005887 catalytic nucleophile [active] 701177005888 Presynaptic Site I dimer interface [polypeptide binding]; other site 701177005889 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 701177005890 Synaptic Flat tetramer interface [polypeptide binding]; other site 701177005891 Synaptic Site I dimer interface [polypeptide binding]; other site 701177005892 DNA binding site [nucleotide binding] 701177005893 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 701177005894 DNA-binding interface [nucleotide binding]; DNA binding site 701177005895 Phage protein U [General function prediction only]; Region: COG3499 701177005896 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 701177005897 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 701177005898 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 701177005899 Phage tail tube protein FII; Region: Phage_tube; cl01390 701177005900 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 701177005901 tail protein; Provisional; Region: D; PHA02561 701177005902 DNA-binding transcriptional regulator; Provisional; Region: PRK09678 701177005903 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 701177005904 Hok/gef family; Region: HOK_GEF; pfam01848 701177005905 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 701177005906 IHF dimer interface [polypeptide binding]; other site 701177005907 IHF - DNA interface [nucleotide binding]; other site 701177005908 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 701177005909 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 701177005910 putative tRNA-binding site [nucleotide binding]; other site 701177005911 B3/4 domain; Region: B3_4; pfam03483 701177005912 tRNA synthetase B5 domain; Region: B5; smart00874 701177005913 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 701177005914 dimer interface [polypeptide binding]; other site 701177005915 motif 1; other site 701177005916 motif 3; other site 701177005917 motif 2; other site 701177005918 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 701177005919 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 701177005920 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 701177005921 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 701177005922 dimer interface [polypeptide binding]; other site 701177005923 motif 1; other site 701177005924 active site 701177005925 motif 2; other site 701177005926 motif 3; other site 701177005927 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 701177005928 23S rRNA binding site [nucleotide binding]; other site 701177005929 L21 binding site [polypeptide binding]; other site 701177005930 L13 binding site [polypeptide binding]; other site 701177005931 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 701177005932 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 701177005933 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 701177005934 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 701177005935 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 701177005936 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 701177005937 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 701177005938 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 701177005939 active site 701177005940 dimer interface [polypeptide binding]; other site 701177005941 motif 1; other site 701177005942 motif 2; other site 701177005943 motif 3; other site 701177005944 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 701177005945 anticodon binding site; other site 701177005946 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 701177005947 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 701177005948 6-phosphofructokinase 2; Provisional; Region: PRK10294 701177005949 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 701177005950 putative substrate binding site [chemical binding]; other site 701177005951 putative ATP binding site [chemical binding]; other site 701177005952 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 701177005953 Phosphotransferase enzyme family; Region: APH; pfam01636 701177005954 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 701177005955 active site 701177005956 ATP binding site [chemical binding]; other site 701177005957 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 701177005958 YniB-like protein; Region: YniB; pfam14002 701177005959 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 701177005960 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 701177005961 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 701177005962 motif II; other site 701177005963 inner membrane protein; Provisional; Region: PRK11648 701177005964 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 701177005965 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 701177005966 cell division modulator; Provisional; Region: PRK10113 701177005967 hydroperoxidase II; Provisional; Region: katE; PRK11249 701177005968 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 701177005969 tetramer interface [polypeptide binding]; other site 701177005970 heme binding pocket [chemical binding]; other site 701177005971 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 701177005972 domain interactions; other site 701177005973 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 701177005974 putative active site [active] 701177005975 YdjC motif; other site 701177005976 Mg binding site [ion binding]; other site 701177005977 putative homodimer interface [polypeptide binding]; other site 701177005978 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 701177005979 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 701177005980 NAD binding site [chemical binding]; other site 701177005981 sugar binding site [chemical binding]; other site 701177005982 divalent metal binding site [ion binding]; other site 701177005983 tetramer (dimer of dimers) interface [polypeptide binding]; other site 701177005984 dimer interface [polypeptide binding]; other site 701177005985 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 701177005986 Cupin domain; Region: Cupin_2; pfam07883 701177005987 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 701177005988 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 701177005989 methionine cluster; other site 701177005990 active site 701177005991 phosphorylation site [posttranslational modification] 701177005992 metal binding site [ion binding]; metal-binding site 701177005993 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 701177005994 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 701177005995 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 701177005996 active site 701177005997 P-loop; other site 701177005998 phosphorylation site [posttranslational modification] 701177005999 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 701177006000 NAD+ synthetase; Region: nadE; TIGR00552 701177006001 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 701177006002 homodimer interface [polypeptide binding]; other site 701177006003 NAD binding pocket [chemical binding]; other site 701177006004 ATP binding pocket [chemical binding]; other site 701177006005 Mg binding site [ion binding]; other site 701177006006 active-site loop [active] 701177006007 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 701177006008 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 701177006009 GIY-YIG motif/motif A; other site 701177006010 active site 701177006011 catalytic site [active] 701177006012 putative DNA binding site [nucleotide binding]; other site 701177006013 metal binding site [ion binding]; metal-binding site 701177006014 hypothetical protein; Provisional; Region: PRK11396 701177006015 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 701177006016 dimer interface [polypeptide binding]; other site 701177006017 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 701177006018 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 701177006019 putative active site [active] 701177006020 Zn binding site [ion binding]; other site 701177006021 succinylarginine dihydrolase; Provisional; Region: PRK13281 701177006022 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 701177006023 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 701177006024 NAD(P) binding site [chemical binding]; other site 701177006025 catalytic residues [active] 701177006026 arginine succinyltransferase; Provisional; Region: PRK10456 701177006027 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 701177006028 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 701177006029 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 701177006030 inhibitor-cofactor binding pocket; inhibition site 701177006031 pyridoxal 5'-phosphate binding site [chemical binding]; other site 701177006032 catalytic residue [active] 701177006033 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 701177006034 putative catalytic site [active] 701177006035 putative phosphate binding site [ion binding]; other site 701177006036 active site 701177006037 metal binding site A [ion binding]; metal-binding site 701177006038 DNA binding site [nucleotide binding] 701177006039 putative AP binding site [nucleotide binding]; other site 701177006040 putative metal binding site B [ion binding]; other site 701177006041 Uncharacterized conserved protein [Function unknown]; Region: COG0398 701177006042 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 701177006043 Uncharacterized conserved protein [Function unknown]; Region: COG0398 701177006044 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 701177006045 Uncharacterized conserved protein [Function unknown]; Region: COG2128 701177006046 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 701177006047 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 701177006048 hypothetical protein; Provisional; Region: PRK11622 701177006049 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135 701177006050 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 701177006051 dimer interface [polypeptide binding]; other site 701177006052 conserved gate region; other site 701177006053 putative PBP binding loops; other site 701177006054 ABC-ATPase subunit interface; other site 701177006055 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 701177006056 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 701177006057 Walker A/P-loop; other site 701177006058 ATP binding site [chemical binding]; other site 701177006059 Q-loop/lid; other site 701177006060 ABC transporter signature motif; other site 701177006061 Walker B; other site 701177006062 D-loop; other site 701177006063 H-loop/switch region; other site 701177006064 Rhodanese Homology Domain; Region: RHOD; smart00450 701177006065 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 701177006066 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 701177006067 active site residue [active] 701177006068 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 701177006069 active site residue [active] 701177006070 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 701177006071 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 701177006072 active site 701177006073 8-oxo-dGMP binding site [chemical binding]; other site 701177006074 nudix motif; other site 701177006075 metal binding site [ion binding]; metal-binding site 701177006076 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 701177006077 glutamate dehydrogenase; Provisional; Region: PRK09414 701177006078 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 701177006079 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 701177006080 NAD(P) binding site [chemical binding]; other site 701177006081 hypothetical protein; Provisional; Region: PRK11380 701177006082 DNA topoisomerase III; Provisional; Region: PRK07726 701177006083 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 701177006084 active site 701177006085 putative interdomain interaction site [polypeptide binding]; other site 701177006086 putative metal-binding site [ion binding]; other site 701177006087 putative nucleotide binding site [chemical binding]; other site 701177006088 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 701177006089 domain I; other site 701177006090 DNA binding groove [nucleotide binding] 701177006091 phosphate binding site [ion binding]; other site 701177006092 domain II; other site 701177006093 domain III; other site 701177006094 nucleotide binding site [chemical binding]; other site 701177006095 catalytic site [active] 701177006096 domain IV; other site 701177006097 selenophosphate synthetase; Provisional; Region: PRK00943 701177006098 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 701177006099 dimerization interface [polypeptide binding]; other site 701177006100 putative ATP binding site [chemical binding]; other site 701177006101 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 701177006102 putative FMN binding site [chemical binding]; other site 701177006103 protease 4; Provisional; Region: PRK10949 701177006104 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 701177006105 tandem repeat interface [polypeptide binding]; other site 701177006106 oligomer interface [polypeptide binding]; other site 701177006107 active site residues [active] 701177006108 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 701177006109 tandem repeat interface [polypeptide binding]; other site 701177006110 oligomer interface [polypeptide binding]; other site 701177006111 active site residues [active] 701177006112 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859 701177006113 Uncharacterized conserved protein [Function unknown]; Region: COG2968 701177006114 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 701177006115 active site 701177006116 homodimer interface [polypeptide binding]; other site 701177006117 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 701177006118 Isochorismatase family; Region: Isochorismatase; pfam00857 701177006119 catalytic triad [active] 701177006120 metal binding site [ion binding]; metal-binding site 701177006121 conserved cis-peptide bond; other site 701177006122 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 701177006123 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177006124 putative substrate translocation pore; other site 701177006125 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177006126 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 701177006127 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 701177006128 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 701177006129 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 701177006130 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 701177006131 active site 701177006132 catalytic tetrad [active] 701177006133 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 701177006134 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 701177006135 substrate binding site [chemical binding]; other site 701177006136 ATP binding site [chemical binding]; other site 701177006137 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 701177006138 intersubunit interface [polypeptide binding]; other site 701177006139 active site 701177006140 zinc binding site [ion binding]; other site 701177006141 Na+ binding site [ion binding]; other site 701177006142 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 701177006143 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 701177006144 inhibitor binding site; inhibition site 701177006145 catalytic Zn binding site [ion binding]; other site 701177006146 structural Zn binding site [ion binding]; other site 701177006147 NADP binding site [chemical binding]; other site 701177006148 tetramer interface [polypeptide binding]; other site 701177006149 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 701177006150 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 701177006151 putative NAD(P) binding site [chemical binding]; other site 701177006152 catalytic Zn binding site [ion binding]; other site 701177006153 structural Zn binding site [ion binding]; other site 701177006154 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 701177006155 methionine sulfoxide reductase B; Provisional; Region: PRK00222 701177006156 SelR domain; Region: SelR; pfam01641 701177006157 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 701177006158 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 701177006159 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 701177006160 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 701177006161 active site 701177006162 phosphate binding residues; other site 701177006163 catalytic residues [active] 701177006164 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 701177006165 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 701177006166 active site 701177006167 catalytic tetrad [active] 701177006168 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 701177006169 PrkA family serine protein kinase; Provisional; Region: PRK15455 701177006170 AAA ATPase domain; Region: AAA_16; pfam13191 701177006171 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 701177006172 hypothetical protein; Provisional; Region: PRK05325 701177006173 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 701177006174 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 701177006175 metal binding site [ion binding]; metal-binding site 701177006176 active site 701177006177 I-site; other site 701177006178 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 701177006179 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 701177006180 metal binding site [ion binding]; metal-binding site 701177006181 active site 701177006182 I-site; other site 701177006183 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 701177006184 putative deacylase active site [active] 701177006185 Predicted membrane protein [Function unknown]; Region: COG2707 701177006186 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 701177006187 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 701177006188 cyanate transporter; Region: CynX; TIGR00896 701177006189 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177006190 Uncharacterized conserved protein [Function unknown]; Region: COG3189 701177006191 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 701177006192 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 701177006193 Domain of unknown function (DUF333); Region: DUF333; pfam03891 701177006194 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 701177006195 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 701177006196 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 701177006197 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 701177006198 metal binding site [ion binding]; metal-binding site 701177006199 active site 701177006200 I-site; other site 701177006201 hypothetical protein; Provisional; Region: PRK10457 701177006202 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 701177006203 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 701177006204 leucine export protein LeuE; Provisional; Region: PRK10958 701177006205 transcriptional activator TtdR; Provisional; Region: PRK09801 701177006206 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 701177006207 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 701177006208 putative effector binding pocket; other site 701177006209 putative dimerization interface [polypeptide binding]; other site 701177006210 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 701177006211 tartrate dehydrogenase; Region: TTC; TIGR02089 701177006212 putative transporter; Provisional; Region: PRK09950 701177006213 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 701177006214 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 701177006215 [2Fe-2S] cluster binding site [ion binding]; other site 701177006216 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_2; cd08886 701177006217 putative alpha subunit interface [polypeptide binding]; other site 701177006218 putative active site [active] 701177006219 putative substrate binding site [chemical binding]; other site 701177006220 Fe binding site [ion binding]; other site 701177006221 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 701177006222 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 701177006223 FMN-binding pocket [chemical binding]; other site 701177006224 flavin binding motif; other site 701177006225 phosphate binding motif [ion binding]; other site 701177006226 beta-alpha-beta structure motif; other site 701177006227 NAD binding pocket [chemical binding]; other site 701177006228 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 701177006229 catalytic loop [active] 701177006230 iron binding site [ion binding]; other site 701177006231 ribonuclease D; Provisional; Region: PRK10829 701177006232 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 701177006233 catalytic site [active] 701177006234 putative active site [active] 701177006235 putative substrate binding site [chemical binding]; other site 701177006236 Helicase and RNase D C-terminal; Region: HRDC; smart00341 701177006237 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 701177006238 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 701177006239 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 701177006240 acyl-activating enzyme (AAE) consensus motif; other site 701177006241 putative AMP binding site [chemical binding]; other site 701177006242 putative active site [active] 701177006243 putative CoA binding site [chemical binding]; other site 701177006244 Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065 701177006245 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 701177006246 Glycoprotease family; Region: Peptidase_M22; pfam00814 701177006247 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 701177006248 DEAD/DEAH box helicase; Region: DEAD; pfam00270 701177006249 DEAD_2; Region: DEAD_2; pfam06733 701177006250 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 701177006251 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 701177006252 homotrimer interaction site [polypeptide binding]; other site 701177006253 putative active site [active] 701177006254 Domain of unknown function (DUF1889); Region: DUF1889; pfam08986 701177006255 hypothetical protein; Provisional; Region: PRK05114 701177006256 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 701177006257 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 701177006258 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 701177006259 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 701177006260 putative active site [active] 701177006261 putative CoA binding site [chemical binding]; other site 701177006262 nudix motif; other site 701177006263 metal binding site [ion binding]; metal-binding site 701177006264 L-serine deaminase; Provisional; Region: PRK15023 701177006265 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 701177006266 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 701177006267 phage resistance protein; Provisional; Region: PRK10551 701177006268 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 701177006269 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 701177006270 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 701177006271 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 701177006272 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 701177006273 Transporter associated domain; Region: CorC_HlyC; smart01091 701177006274 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 701177006275 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 701177006276 active pocket/dimerization site; other site 701177006277 active site 701177006278 phosphorylation site [posttranslational modification] 701177006279 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 701177006280 active site 701177006281 phosphorylation site [posttranslational modification] 701177006282 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 701177006283 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 701177006284 Predicted membrane protein [Function unknown]; Region: COG4811 701177006285 hypothetical protein; Provisional; Region: PRK11469 701177006286 Domain of unknown function DUF; Region: DUF204; pfam02659 701177006287 Domain of unknown function DUF; Region: DUF204; pfam02659 701177006288 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 701177006289 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 701177006290 S-adenosylmethionine binding site [chemical binding]; other site 701177006291 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 701177006292 DNA-binding site [nucleotide binding]; DNA binding site 701177006293 RNA-binding motif; other site 701177006294 Protein of unknown function (DUF2627); Region: DUF2527; pfam10736 701177006295 YebO-like protein; Region: YebO; pfam13974 701177006296 PhoPQ regulatory protein; Provisional; Region: PRK10299 701177006297 YobH-like protein; Region: YobH; pfam13996 701177006298 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 701177006299 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 701177006300 dimerization interface [polypeptide binding]; other site 701177006301 putative Zn2+ binding site [ion binding]; other site 701177006302 putative DNA binding site [nucleotide binding]; other site 701177006303 Bacterial transcriptional regulator; Region: IclR; pfam01614 701177006304 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177006305 Major Facilitator Superfamily; Region: MFS_1; pfam07690 701177006306 putative substrate translocation pore; other site 701177006307 Predicted integral membrane protein [Function unknown]; Region: COG5521 701177006308 heat shock protein HtpX; Provisional; Region: PRK05457 701177006309 carboxy-terminal protease; Provisional; Region: PRK11186 701177006310 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 701177006311 protein binding site [polypeptide binding]; other site 701177006312 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 701177006313 Catalytic dyad [active] 701177006314 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 701177006315 ProP expression regulator; Provisional; Region: PRK04950 701177006316 ProQ/FINO family; Region: ProQ; pfam04352 701177006317 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 701177006318 GAF domain; Region: GAF_2; pfam13185 701177006319 integral membrane protein, PqiA family; Region: pqiA_fam; TIGR00155 701177006320 Paraquat-inducible protein A; Region: PqiA; pfam04403 701177006321 Paraquat-inducible protein A; Region: PqiA; pfam04403 701177006322 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 701177006323 mce related protein; Region: MCE; pfam02470 701177006324 mce related protein; Region: MCE; pfam02470 701177006325 mce related protein; Region: MCE; pfam02470 701177006326 mce related protein; Region: MCE; pfam02470 701177006327 mce related protein; Region: MCE; pfam02470 701177006328 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 701177006329 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 701177006330 S-adenosylmethionine binding site [chemical binding]; other site 701177006331 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 701177006332 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 701177006333 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 701177006334 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 701177006335 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 701177006336 active site 701177006337 metal binding site [ion binding]; metal-binding site 701177006338 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 701177006339 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 701177006340 hypothetical protein; Provisional; Region: PRK10301 701177006341 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 701177006342 Predicted amidohydrolase [General function prediction only]; Region: COG0388 701177006343 Carbon-nitrogen hydrolase; Region: CN_hydrolase; pfam00795 701177006344 exodeoxyribonuclease X; Provisional; Region: PRK07983 701177006345 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 701177006346 active site 701177006347 catalytic site [active] 701177006348 substrate binding site [chemical binding]; other site 701177006349 protease 2; Provisional; Region: PRK10115 701177006350 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 701177006351 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 701177006352 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 701177006353 putative metal binding site [ion binding]; other site 701177006354 hypothetical protein; Provisional; Region: PRK13680 701177006355 DNA damage-inducible protein YebG; Provisional; Region: PRK10061 701177006356 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 701177006357 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 701177006358 ATP-grasp domain; Region: ATP-grasp; pfam02222 701177006359 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 701177006360 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 701177006361 active site 701177006362 intersubunit interface [polypeptide binding]; other site 701177006363 catalytic residue [active] 701177006364 phosphogluconate dehydratase; Validated; Region: PRK09054 701177006365 6-phosphogluconate dehydratase; Region: edd; TIGR01196 701177006366 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 701177006367 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 701177006368 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 701177006369 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 701177006370 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 701177006371 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 701177006372 putative active site [active] 701177006373 pyruvate kinase; Provisional; Region: PRK05826 701177006374 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 701177006375 domain interfaces; other site 701177006376 active site 701177006377 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 701177006378 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 701177006379 putative acyl-acceptor binding pocket; other site 701177006380 putative peptidase; Provisional; Region: PRK11649 701177006381 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 701177006382 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 701177006383 Peptidase family M23; Region: Peptidase_M23; pfam01551 701177006384 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 701177006385 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 701177006386 metal binding site [ion binding]; metal-binding site 701177006387 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 701177006388 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 701177006389 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 701177006390 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 701177006391 ABC-ATPase subunit interface; other site 701177006392 dimer interface [polypeptide binding]; other site 701177006393 putative PBP binding regions; other site 701177006394 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 701177006395 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 701177006396 Walker A motif; other site 701177006397 ATP binding site [chemical binding]; other site 701177006398 Walker B motif; other site 701177006399 arginine finger; other site 701177006400 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 701177006401 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 701177006402 RuvA N terminal domain; Region: RuvA_N; pfam01330 701177006403 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 701177006404 hypothetical protein; Provisional; Region: PRK11470 701177006405 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 701177006406 active site 701177006407 putative DNA-binding cleft [nucleotide binding]; other site 701177006408 dimer interface [polypeptide binding]; other site 701177006409 hypothetical protein; Validated; Region: PRK00110 701177006410 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 701177006411 nudix motif; other site 701177006412 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 701177006413 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 701177006414 dimer interface [polypeptide binding]; other site 701177006415 anticodon binding site; other site 701177006416 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 701177006417 homodimer interface [polypeptide binding]; other site 701177006418 motif 1; other site 701177006419 active site 701177006420 motif 2; other site 701177006421 GAD domain; Region: GAD; pfam02938 701177006422 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 701177006423 motif 3; other site 701177006424 Isochorismatase family; Region: Isochorismatase; pfam00857 701177006425 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 701177006426 catalytic triad [active] 701177006427 conserved cis-peptide bond; other site 701177006428 hypothetical protein; Provisional; Region: PRK10302 701177006429 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 701177006430 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 701177006431 S-adenosylmethionine binding site [chemical binding]; other site 701177006432 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 701177006433 S-adenosylmethionine binding site [chemical binding]; other site 701177006434 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 701177006435 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 701177006436 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 701177006437 molybdopterin cofactor binding site [chemical binding]; other site 701177006438 substrate binding site [chemical binding]; other site 701177006439 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 701177006440 molybdopterin cofactor binding site; other site 701177006441 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 701177006442 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 701177006443 copper homeostasis protein CutC; Provisional; Region: PRK11572 701177006444 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 701177006445 putative metal binding site [ion binding]; other site 701177006446 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 701177006447 arginyl-tRNA synthetase; Region: argS; TIGR00456 701177006448 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 701177006449 active site 701177006450 HIGH motif; other site 701177006451 KMSK motif region; other site 701177006452 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 701177006453 tRNA binding surface [nucleotide binding]; other site 701177006454 anticodon binding site; other site 701177006455 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 701177006456 Flagellar protein FlhE; Region: FlhE; pfam06366 701177006457 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 701177006458 FHIPEP family; Region: FHIPEP; pfam00771 701177006459 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 701177006460 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 701177006461 chemotaxis regulator CheZ; Provisional; Region: PRK11166 701177006462 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 701177006463 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 701177006464 active site 701177006465 phosphorylation site [posttranslational modification] 701177006466 intermolecular recognition site; other site 701177006467 dimerization interface [polypeptide binding]; other site 701177006468 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 701177006469 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 701177006470 active site 701177006471 phosphorylation site [posttranslational modification] 701177006472 intermolecular recognition site; other site 701177006473 dimerization interface [polypeptide binding]; other site 701177006474 CheB methylesterase; Region: CheB_methylest; pfam01339 701177006475 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 701177006476 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 701177006477 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 701177006478 S-adenosylmethionine binding site [chemical binding]; other site 701177006479 methyl-accepting protein IV; Provisional; Region: PRK09793 701177006480 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 701177006481 dimer interface [polypeptide binding]; other site 701177006482 ligand binding site [chemical binding]; other site 701177006483 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 701177006484 dimerization interface [polypeptide binding]; other site 701177006485 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 701177006486 dimer interface [polypeptide binding]; other site 701177006487 putative CheW interface [polypeptide binding]; other site 701177006488 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 701177006489 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 701177006490 dimer interface [polypeptide binding]; other site 701177006491 ligand binding site [chemical binding]; other site 701177006492 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 701177006493 dimerization interface [polypeptide binding]; other site 701177006494 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 701177006495 dimer interface [polypeptide binding]; other site 701177006496 putative CheW interface [polypeptide binding]; other site 701177006497 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 701177006498 putative CheA interaction surface; other site 701177006499 chemotaxis protein CheA; Provisional; Region: PRK10547 701177006500 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 701177006501 putative binding surface; other site 701177006502 active site 701177006503 CheY binding; Region: CheY-binding; pfam09078 701177006504 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 701177006505 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 701177006506 ATP binding site [chemical binding]; other site 701177006507 Mg2+ binding site [ion binding]; other site 701177006508 G-X-G motif; other site 701177006509 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 701177006510 flagellar motor protein MotB; Validated; Region: motB; PRK09041 701177006511 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 701177006512 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 701177006513 ligand binding site [chemical binding]; other site 701177006514 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 701177006515 flagellar motor protein MotA; Validated; Region: PRK09110 701177006516 transcriptional activator FlhC; Provisional; Region: PRK12722 701177006517 transcriptional activator FlhD; Provisional; Region: PRK02909 701177006518 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 701177006519 Ligand Binding Site [chemical binding]; other site 701177006520 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 701177006521 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 701177006522 active site 701177006523 homotetramer interface [polypeptide binding]; other site 701177006524 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187 701177006525 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 701177006526 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 701177006527 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 701177006528 TM-ABC transporter signature motif; other site 701177006529 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 701177006530 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 701177006531 Walker A/P-loop; other site 701177006532 ATP binding site [chemical binding]; other site 701177006533 Q-loop/lid; other site 701177006534 ABC transporter signature motif; other site 701177006535 Walker B; other site 701177006536 D-loop; other site 701177006537 H-loop/switch region; other site 701177006538 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 701177006539 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 701177006540 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 701177006541 ligand binding site [chemical binding]; other site 701177006542 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 701177006543 Ferritin-like domain; Region: Ferritin; pfam00210 701177006544 ferroxidase diiron center [ion binding]; other site 701177006545 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 701177006546 YecR-like lipoprotein; Region: YecR; pfam13992 701177006547 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 701177006548 Ferritin-like domain; Region: Ferritin; pfam00210 701177006549 ferroxidase diiron center [ion binding]; other site 701177006550 probable metal-binding protein; Region: matur_matur; TIGR03853 701177006551 tyrosine transporter TyrP; Provisional; Region: PRK15132 701177006552 aromatic amino acid transport protein; Region: araaP; TIGR00837 701177006553 hypothetical protein; Provisional; Region: PRK10396 701177006554 yecA family protein; Region: ygfB_yecA; TIGR02292 701177006555 SEC-C motif; Region: SEC-C; pfam02810 701177006556 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 701177006557 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 701177006558 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 701177006559 GIY-YIG motif/motif A; other site 701177006560 active site 701177006561 catalytic site [active] 701177006562 putative DNA binding site [nucleotide binding]; other site 701177006563 metal binding site [ion binding]; metal-binding site 701177006564 UvrB/uvrC motif; Region: UVR; pfam02151 701177006565 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 701177006566 Helix-hairpin-helix motif; Region: HHH; pfam00633 701177006567 response regulator; Provisional; Region: PRK09483 701177006568 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 701177006569 active site 701177006570 phosphorylation site [posttranslational modification] 701177006571 intermolecular recognition site; other site 701177006572 dimerization interface [polypeptide binding]; other site 701177006573 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 701177006574 DNA binding residues [nucleotide binding] 701177006575 dimerization interface [polypeptide binding]; other site 701177006576 hypothetical protein; Provisional; Region: PRK10613 701177006577 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 701177006578 Autoinducer binding domain; Region: Autoind_bind; pfam03472 701177006579 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 701177006580 DNA binding residues [nucleotide binding] 701177006581 dimerization interface [polypeptide binding]; other site 701177006582 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 701177006583 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 701177006584 Walker A/P-loop; other site 701177006585 ATP binding site [chemical binding]; other site 701177006586 Q-loop/lid; other site 701177006587 ABC transporter signature motif; other site 701177006588 Walker B; other site 701177006589 D-loop; other site 701177006590 H-loop/switch region; other site 701177006591 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 701177006592 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 701177006593 dimer interface [polypeptide binding]; other site 701177006594 conserved gate region; other site 701177006595 putative PBP binding loops; other site 701177006596 ABC-ATPase subunit interface; other site 701177006597 D-cysteine desulfhydrase; Validated; Region: PRK03910 701177006598 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 701177006599 pyridoxal 5'-phosphate binding site [chemical binding]; other site 701177006600 catalytic residue [active] 701177006601 cystine transporter subunit; Provisional; Region: PRK11260 701177006602 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 701177006603 substrate binding pocket [chemical binding]; other site 701177006604 membrane-bound complex binding site; other site 701177006605 hinge residues; other site 701177006606 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 701177006607 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 701177006608 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 701177006609 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 701177006610 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 701177006611 DNA binding residues [nucleotide binding] 701177006612 flagellin; Validated; Region: PRK08026 701177006613 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 701177006614 Flagellin protein; Region: FliC; pfam12445 701177006615 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 701177006616 flagellar capping protein; Reviewed; Region: fliD; PRK08032 701177006617 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 701177006618 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 701177006619 Flagellar protein FliS; Region: FliS; cl00654 701177006620 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 701177006621 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 701177006622 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 701177006623 active site 701177006624 Na/Ca binding site [ion binding]; other site 701177006625 catalytic site [active] 701177006626 lipoprotein; Provisional; Region: PRK10397 701177006627 putative inner membrane protein; Provisional; Region: PRK11099 701177006628 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 701177006629 CPxP motif; other site 701177006630 hypothetical protein; Provisional; Region: PRK09951 701177006631 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 701177006632 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 701177006633 Coenzyme A binding pocket [chemical binding]; other site 701177006634 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 701177006635 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 701177006636 Coenzyme A binding pocket [chemical binding]; other site 701177006637 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 701177006638 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 701177006639 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 701177006640 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 701177006641 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 701177006642 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 701177006643 flagellar motor switch protein FliG; Region: fliG; TIGR00207 701177006644 FliG C-terminal domain; Region: FliG_C; pfam01706 701177006645 flagellar assembly protein H; Validated; Region: fliH; PRK05687 701177006646 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 701177006647 Flagellar assembly protein FliH; Region: FliH; pfam02108 701177006648 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 701177006649 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 701177006650 Walker A motif/ATP binding site; other site 701177006651 Walker B motif; other site 701177006652 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 701177006653 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 701177006654 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 701177006655 flagellar hook-length control protein; Provisional; Region: PRK10118 701177006656 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 701177006657 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 701177006658 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 701177006659 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 701177006660 flagellar motor switch protein; Validated; Region: fliN; PRK05698 701177006661 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 701177006662 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 701177006663 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 701177006664 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 701177006665 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 701177006666 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 701177006667 DNA binding residues [nucleotide binding] 701177006668 dimerization interface [polypeptide binding]; other site 701177006669 hypothetical protein; Provisional; Region: PRK10708 701177006670 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 701177006671 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 701177006672 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 701177006673 active site 701177006674 motif I; other site 701177006675 motif II; other site 701177006676 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 701177006677 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 701177006678 metal binding site [ion binding]; metal-binding site 701177006679 active site 701177006680 I-site; other site 701177006681 Uncharacterized small protein [Function unknown]; Region: COG5475 701177006682 hypothetical protein; Provisional; Region: PRK10062 701177006683 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 701177006684 EamA-like transporter family; Region: EamA; pfam00892 701177006685 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 701177006686 additional DNA contacts [nucleotide binding]; other site 701177006687 mismatch recognition site; other site 701177006688 active site 701177006689 zinc binding site [ion binding]; other site 701177006690 DNA intercalation site [nucleotide binding]; other site 701177006691 DNA cytosine methylase; Provisional; Region: PRK10458 701177006692 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 701177006693 cofactor binding site; other site 701177006694 DNA binding site [nucleotide binding] 701177006695 substrate interaction site [chemical binding]; other site 701177006696 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 701177006697 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 701177006698 Zn2+ binding site [ion binding]; other site 701177006699 Mg2+ binding site [ion binding]; other site 701177006700 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 701177006701 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 701177006702 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 701177006703 trimer interface [polypeptide binding]; other site 701177006704 eyelet of channel; other site 701177006705 chaperone protein HchA; Provisional; Region: PRK04155 701177006706 Type 1 glutamine amidotransferase (GATase1)-like domain found in Escherichia coli Hsp31 protein (EcHsp31); Region: GATase1_EcHsp31_like; cd03148 701177006707 dimer interface [polypeptide binding]; other site 701177006708 metal binding site [ion binding]; metal-binding site 701177006709 potential oxyanion hole; other site 701177006710 potential catalytic triad [active] 701177006711 conserved cys residue [active] 701177006712 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 701177006713 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 701177006714 dimer interface [polypeptide binding]; other site 701177006715 phosphorylation site [posttranslational modification] 701177006716 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 701177006717 ATP binding site [chemical binding]; other site 701177006718 Mg2+ binding site [ion binding]; other site 701177006719 G-X-G motif; other site 701177006720 transcriptional regulatory protein YedW; Provisional; Region: PRK11517 701177006721 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 701177006722 active site 701177006723 phosphorylation site [posttranslational modification] 701177006724 intermolecular recognition site; other site 701177006725 dimerization interface [polypeptide binding]; other site 701177006726 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 701177006727 DNA binding site [nucleotide binding] 701177006728 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 701177006729 active site 701177006730 homotetramer interface [polypeptide binding]; other site 701177006731 TMAO/DMSO reductase; Reviewed; Region: PRK05363 701177006732 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 701177006733 Moco binding site; other site 701177006734 metal coordination site [ion binding]; other site 701177006735 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 701177006736 zinc/cadmium-binding protein; Provisional; Region: PRK10306 701177006737 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 701177006738 AvrPphF-ORF-2; Region: AvrPphF-ORF-2; pfam09143 701177006739 EspF protein repeat; Region: EspF; pfam04806 701177006740 EspF protein repeat; Region: EspF; pfam04806 701177006741 EspF protein repeat; Region: EspF; pfam04806 701177006742 EspF protein repeat; Region: EspF; pfam04806 701177006743 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 701177006744 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 701177006745 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 701177006746 Phage-related protein, tail component [Function unknown]; Region: COG4733 701177006747 Putative phage tail protein; Region: Phage-tail_3; pfam13550 701177006748 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 701177006749 Fibronectin type III protein; Region: DUF3672; pfam12421 701177006750 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 701177006751 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 701177006752 E-class dimer interface [polypeptide binding]; other site 701177006753 P-class dimer interface [polypeptide binding]; other site 701177006754 active site 701177006755 Cu2+ binding site [ion binding]; other site 701177006756 Zn2+ binding site [ion binding]; other site 701177006757 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 701177006758 MPN+ (JAMM) motif; other site 701177006759 Zinc-binding site [ion binding]; other site 701177006760 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 701177006761 NlpC/P60 family; Region: NLPC_P60; cl17555 701177006762 Phage-related protein [Function unknown]; Region: gp18; COG4672 701177006763 Phage-related protein [Function unknown]; Region: COG4718 701177006764 Phage-related minor tail protein [Function unknown]; Region: COG5281 701177006765 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 701177006766 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 701177006767 phage tail assembly protein T; Region: phage_lam_T; TIGR01715 701177006768 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894 701177006769 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 701177006770 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 701177006771 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 701177006772 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 701177006773 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 701177006774 DNA packaging protein FI; Region: Packaging_FI; pfam14000 701177006775 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 701177006776 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 701177006777 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 701177006778 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 701177006779 tandem repeat interface [polypeptide binding]; other site 701177006780 oligomer interface [polypeptide binding]; other site 701177006781 active site residues [active] 701177006782 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 701177006783 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 701177006784 gpW; Region: gpW; pfam02831 701177006785 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 701177006786 Phage DNA packaging protein, Nu1 subunit of terminase [DNA replication, recombination, and repair]; Region: COG4220 701177006787 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 701177006788 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 701177006789 catalytic residues [active] 701177006790 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 701177006791 Lysis protein S; Region: Lysis_S; pfam04971 701177006792 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 701177006793 Domain of unknown function (DUF303); Region: DUF303; pfam03629 701177006794 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 701177006795 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 701177006796 CAAX protease self-immunity; Region: Abi; pfam02517 701177006797 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 701177006798 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 701177006799 Protein of unknown function (DUF968); Region: DUF968; pfam06147 701177006800 adenylosuccinate lyase; Provisional; Region: PRK09285 701177006801 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 701177006802 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 701177006803 non-specific DNA binding site [nucleotide binding]; other site 701177006804 salt bridge; other site 701177006805 sequence-specific DNA binding site [nucleotide binding]; other site 701177006806 Domain of unknown function (DUF955); Region: DUF955; cl01076 701177006807 Hok/gef family; Region: HOK_GEF; pfam01848 701177006808 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 701177006809 primosomal protein DnaI; Provisional; Region: PRK02854 701177006810 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 701177006811 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 701177006812 transcriptional repressor DicA; Reviewed; Region: PRK09706 701177006813 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 701177006814 non-specific DNA binding site [nucleotide binding]; other site 701177006815 salt bridge; other site 701177006816 sequence-specific DNA binding site [nucleotide binding]; other site 701177006817 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 701177006818 DicB protein; Region: DicB; pfam05358 701177006819 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 701177006820 exonuclease VIII; Reviewed; Region: PRK09709 701177006821 Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630 701177006822 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 701177006823 active site 701177006824 substrate binding site [chemical binding]; other site 701177006825 catalytic site [active] 701177006826 Domain of unknown function (DUF4224); Region: DUF4224; pfam13986 701177006827 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 701177006828 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 701177006829 active site 701177006830 DNA binding site [nucleotide binding] 701177006831 Int/Topo IB signature motif; other site 701177006832 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 701177006833 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 701177006834 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 701177006835 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 701177006836 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 701177006837 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 701177006838 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 701177006839 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 701177006840 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 701177006841 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 701177006842 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 701177006843 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 701177006844 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 701177006845 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 701177006846 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 701177006847 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 701177006848 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 701177006849 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 701177006850 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 701177006851 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 701177006852 shikimate transporter; Provisional; Region: PRK09952 701177006853 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177006854 putative substrate translocation pore; other site 701177006855 AMP nucleosidase; Provisional; Region: PRK08292 701177006856 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 701177006857 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 701177006858 hypothetical protein; Provisional; Region: PRK12378 701177006859 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 701177006860 putative efflux protein, MATE family; Region: matE; TIGR00797 701177006861 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 701177006862 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 701177006863 The C-terminal substrate binding domain of LysR-type transcriptional regulator Cbl, which is required for expression of sulfate starvation-inducible (ssi) genes, contains the type 2 periplasmic binding fold; Region: PBP2_Cbl; cd08444 701177006864 putative substrate binding site [chemical binding]; other site 701177006865 dimerization interface [polypeptide binding]; other site 701177006866 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 701177006867 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 701177006868 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 701177006869 putative dimerization interface [polypeptide binding]; other site 701177006870 L,D-transpeptidase; Provisional; Region: PRK10190 701177006871 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 701177006872 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 701177006873 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 701177006874 putative dimer interface [polypeptide binding]; other site 701177006875 active site pocket [active] 701177006876 putative cataytic base [active] 701177006877 cobalamin 5'-phosphate synthase/cobalamin synthase; Region: cobS; TIGR00317 701177006878 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 701177006879 homotrimer interface [polypeptide binding]; other site 701177006880 Walker A motif; other site 701177006881 GTP binding site [chemical binding]; other site 701177006882 Walker B motif; other site 701177006883 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 701177006884 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 701177006885 N-terminal plug; other site 701177006886 ligand-binding site [chemical binding]; other site 701177006887 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 701177006888 ParB-like nuclease domain; Region: ParBc; cl02129 701177006889 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 701177006890 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 701177006891 Transposase; Region: HTH_Tnp_1; cl17663 701177006892 Integrase core domain; Region: rve; pfam00665 701177006893 DDE domain; Region: DDE_Tnp_IS240; pfam13610 701177006894 Integrase core domain; Region: rve_3; pfam13683 701177006895 Predicted GTPase [General function prediction only]; Region: COG3596 701177006896 YfjP GTPase; Region: YfjP; cd11383 701177006897 G1 box; other site 701177006898 GTP/Mg2+ binding site [chemical binding]; other site 701177006899 Switch I region; other site 701177006900 G2 box; other site 701177006901 Switch II region; other site 701177006902 G3 box; other site 701177006903 G4 box; other site 701177006904 G5 box; other site 701177006905 hypothetical protein; Provisional; Region: PRK09866 701177006906 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 701177006907 G1 box; other site 701177006908 GTP/Mg2+ binding site [chemical binding]; other site 701177006909 G2 box; other site 701177006910 Switch I region; other site 701177006911 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 701177006912 G3 box; other site 701177006913 Switch II region; other site 701177006914 GTP/Mg2+ binding site [chemical binding]; other site 701177006915 G4 box; other site 701177006916 G5 box; other site 701177006917 YjcZ-like protein; Region: YjcZ; pfam13990 701177006918 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 701177006919 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 701177006920 nucleophile elbow; other site 701177006921 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 701177006922 Domain of unknown function (DUF932); Region: DUF932; pfam06067 701177006923 Antirestriction protein; Region: Antirestrict; pfam03230 701177006924 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 701177006925 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 701177006926 MPN+ (JAMM) motif; other site 701177006927 Zinc-binding site [ion binding]; other site 701177006928 Protein of unknown function (DUF987); Region: DUF987; pfam06174 701177006929 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 701177006930 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 701177006931 Switch II region; other site 701177006932 G4 box; other site 701177006933 G5 box; other site 701177006934 hypothetical protein; Provisional; Region: PRK05423 701177006935 Predicted membrane protein [Function unknown]; Region: COG1289 701177006936 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 701177006937 DNA gyrase inhibitor; Provisional; Region: PRK10016 701177006938 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 701177006939 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 701177006940 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 701177006941 exonuclease I; Provisional; Region: sbcB; PRK11779 701177006942 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 701177006943 active site 701177006944 catalytic site [active] 701177006945 substrate binding site [chemical binding]; other site 701177006946 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 701177006947 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 701177006948 CPxP motif; other site 701177006949 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 701177006950 Sulphur transport; Region: Sulf_transp; pfam04143 701177006951 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 701177006952 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 701177006953 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 701177006954 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 701177006955 dimerization interface [polypeptide binding]; other site 701177006956 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 701177006957 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 701177006958 putative NAD(P) binding site [chemical binding]; other site 701177006959 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 701177006960 antitoxin YefM; Provisional; Region: PRK11409 701177006961 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 701177006962 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 701177006963 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 701177006964 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 701177006965 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 701177006966 NAD binding site [chemical binding]; other site 701177006967 dimerization interface [polypeptide binding]; other site 701177006968 product binding site; other site 701177006969 substrate binding site [chemical binding]; other site 701177006970 zinc binding site [ion binding]; other site 701177006971 catalytic residues [active] 701177006972 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 701177006973 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 701177006974 pyridoxal 5'-phosphate binding site [chemical binding]; other site 701177006975 homodimer interface [polypeptide binding]; other site 701177006976 catalytic residue [active] 701177006977 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 701177006978 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 701177006979 active site 701177006980 motif I; other site 701177006981 motif II; other site 701177006982 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 701177006983 putative active site pocket [active] 701177006984 4-fold oligomerization interface [polypeptide binding]; other site 701177006985 metal binding residues [ion binding]; metal-binding site 701177006986 3-fold/trimer interface [polypeptide binding]; other site 701177006987 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 701177006988 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 701177006989 putative active site [active] 701177006990 oxyanion strand; other site 701177006991 catalytic triad [active] 701177006992 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 701177006993 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 701177006994 catalytic residues [active] 701177006995 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 701177006996 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 701177006997 substrate binding site [chemical binding]; other site 701177006998 glutamase interaction surface [polypeptide binding]; other site 701177006999 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 701177007000 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 701177007001 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 701177007002 metal binding site [ion binding]; metal-binding site 701177007003 chain length determinant protein WzzB; Provisional; Region: PRK15471 701177007004 Chain length determinant protein; Region: Wzz; pfam02706 701177007005 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 701177007006 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 701177007007 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 701177007008 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 701177007009 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 701177007010 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 701177007011 Transposase [DNA replication, recombination, and repair]; Region: COG5433 701177007012 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 701177007013 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 701177007014 inhibitor-cofactor binding pocket; inhibition site 701177007015 pyridoxal 5'-phosphate binding site [chemical binding]; other site 701177007016 catalytic residue [active] 701177007017 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 701177007018 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 701177007019 NAD(P) binding site [chemical binding]; other site 701177007020 active site 701177007021 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 701177007022 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 701177007023 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 701177007024 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 701177007025 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 701177007026 active site 701177007027 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 701177007028 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 701177007029 active site 701177007030 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 701177007031 Alpha-1,2-fucosyltransferase; Region: Fut1_Fut2_like; cd11301 701177007032 GDP-Fucose binding site [chemical binding]; other site 701177007033 phosphomannomutase CpsG; Provisional; Region: PRK15414 701177007034 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 701177007035 active site 701177007036 substrate binding site [chemical binding]; other site 701177007037 metal binding site [ion binding]; metal-binding site 701177007038 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 701177007039 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 701177007040 Substrate binding site; other site 701177007041 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 701177007042 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 701177007043 active site 701177007044 GDP-Mannose binding site [chemical binding]; other site 701177007045 dimer interface [polypeptide binding]; other site 701177007046 modified nudix motif 701177007047 metal binding site [ion binding]; metal-binding site 701177007048 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 701177007049 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 701177007050 NADP-binding site; other site 701177007051 homotetramer interface [polypeptide binding]; other site 701177007052 substrate binding site [chemical binding]; other site 701177007053 homodimer interface [polypeptide binding]; other site 701177007054 active site 701177007055 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 701177007056 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 701177007057 putative ADP-binding pocket [chemical binding]; other site 701177007058 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 701177007059 active site 701177007060 tetramer interface; other site 701177007061 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 701177007062 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 701177007063 putative NAD(P) binding site [chemical binding]; other site 701177007064 active site 701177007065 putative substrate binding site [chemical binding]; other site 701177007066 putative colanic acid biosynthesis protein; Provisional; Region: wcaM; PRK10123 701177007067 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 701177007068 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 701177007069 putative ADP-binding pocket [chemical binding]; other site 701177007070 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 701177007071 colanic acid biosynthesis pyruvyl transferase WcaK; Region: wcaK; TIGR04006 701177007072 colanic acid exporter; Provisional; Region: PRK10459 701177007073 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 701177007074 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 701177007075 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 701177007076 phosphomannomutase CpsG; Provisional; Region: PRK15414 701177007077 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 701177007078 active site 701177007079 substrate binding site [chemical binding]; other site 701177007080 metal binding site [ion binding]; metal-binding site 701177007081 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 701177007082 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 701177007083 Substrate binding site; other site 701177007084 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 701177007085 colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007 701177007086 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 701177007087 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 701177007088 active site 701177007089 GDP-Mannose binding site [chemical binding]; other site 701177007090 dimer interface [polypeptide binding]; other site 701177007091 modified nudix motif 701177007092 metal binding site [ion binding]; metal-binding site 701177007093 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 701177007094 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 701177007095 NADP binding site [chemical binding]; other site 701177007096 active site 701177007097 putative substrate binding site [chemical binding]; other site 701177007098 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 701177007099 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 701177007100 NADP-binding site; other site 701177007101 homotetramer interface [polypeptide binding]; other site 701177007102 substrate binding site [chemical binding]; other site 701177007103 homodimer interface [polypeptide binding]; other site 701177007104 active site 701177007105 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 701177007106 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 701177007107 putative trimer interface [polypeptide binding]; other site 701177007108 putative active site [active] 701177007109 putative substrate binding site [chemical binding]; other site 701177007110 putative CoA binding site [chemical binding]; other site 701177007111 putative glycosyl transferase; Provisional; Region: PRK10063 701177007112 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 701177007113 metal-binding site 701177007114 putative colanic acid polymerase WcaD; Region: WcaD; TIGR04010 701177007115 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 701177007116 colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015 701177007117 putative acyl transferase; Provisional; Region: PRK10191 701177007118 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 701177007119 trimer interface [polypeptide binding]; other site 701177007120 active site 701177007121 substrate binding site [chemical binding]; other site 701177007122 CoA binding site [chemical binding]; other site 701177007123 putative glycosyl transferase; Provisional; Region: PRK10018 701177007124 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 701177007125 active site 701177007126 tyrosine kinase; Provisional; Region: PRK11519 701177007127 Chain length determinant protein; Region: Wzz; pfam02706 701177007128 Chain length determinant protein; Region: Wzz; cl15801 701177007129 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 701177007130 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 701177007131 Low molecular weight phosphatase family; Region: LMWPc; cd00115 701177007132 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 701177007133 active site 701177007134 polysaccharide export protein Wza; Provisional; Region: PRK15078 701177007135 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 701177007136 SLBB domain; Region: SLBB; pfam10531 701177007137 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 701177007138 FOG: CBS domain [General function prediction only]; Region: COG0517 701177007139 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 701177007140 Transporter associated domain; Region: CorC_HlyC; smart01091 701177007141 Phage-related protein [Function unknown]; Region: COG4679 701177007142 Uncharacterized conserved small protein [Function unknown]; Region: COG5606 701177007143 putative assembly protein; Provisional; Region: PRK10833 701177007144 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 701177007145 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 701177007146 trimer interface [polypeptide binding]; other site 701177007147 active site 701177007148 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 701177007149 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 701177007150 ATP-binding site [chemical binding]; other site 701177007151 Sugar specificity; other site 701177007152 Pyrimidine base specificity; other site 701177007153 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 701177007154 putative diguanylate cyclase; Provisional; Region: PRK09776 701177007155 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 701177007156 putative active site [active] 701177007157 heme pocket [chemical binding]; other site 701177007158 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 701177007159 putative active site [active] 701177007160 heme pocket [chemical binding]; other site 701177007161 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 701177007162 putative active site [active] 701177007163 heme pocket [chemical binding]; other site 701177007164 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 701177007165 metal binding site [ion binding]; metal-binding site 701177007166 active site 701177007167 I-site; other site 701177007168 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 701177007169 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 701177007170 AlkA N-terminal domain; Region: AlkA_N; smart01009 701177007171 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 701177007172 minor groove reading motif; other site 701177007173 helix-hairpin-helix signature motif; other site 701177007174 substrate binding pocket [chemical binding]; other site 701177007175 active site 701177007176 putative chaperone; Provisional; Region: PRK11678 701177007177 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 701177007178 nucleotide binding site [chemical binding]; other site 701177007179 putative NEF/HSP70 interaction site [polypeptide binding]; other site 701177007180 SBD interface [polypeptide binding]; other site 701177007181 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248 701177007182 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 701177007183 substrate binding site [chemical binding]; other site 701177007184 activation loop (A-loop); other site 701177007185 Protein phosphatase 2C; Region: PP2C_2; pfam13672 701177007186 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 701177007187 metal ion-dependent adhesion site (MIDAS); other site 701177007188 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 701177007189 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 701177007190 HlyD family secretion protein; Region: HlyD_3; pfam13437 701177007191 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 701177007192 Protein export membrane protein; Region: SecD_SecF; cl14618 701177007193 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 701177007194 putative transporter; Provisional; Region: PRK10504 701177007195 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177007196 putative substrate translocation pore; other site 701177007197 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177007198 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 701177007199 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 701177007200 dimerization interface [polypeptide binding]; other site 701177007201 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 701177007202 dimer interface [polypeptide binding]; other site 701177007203 phosphorylation site [posttranslational modification] 701177007204 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 701177007205 ATP binding site [chemical binding]; other site 701177007206 Mg2+ binding site [ion binding]; other site 701177007207 G-X-G motif; other site 701177007208 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 701177007209 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 701177007210 active site 701177007211 phosphorylation site [posttranslational modification] 701177007212 intermolecular recognition site; other site 701177007213 dimerization interface [polypeptide binding]; other site 701177007214 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 701177007215 DNA binding site [nucleotide binding] 701177007216 Uncharacterized conserved protein [Function unknown]; Region: COG3422 701177007217 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 701177007218 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 701177007219 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 701177007220 putative protease; Provisional; Region: PRK15452 701177007221 Peptidase family U32; Region: Peptidase_U32; pfam01136 701177007222 lipid kinase; Reviewed; Region: PRK13054 701177007223 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 701177007224 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 701177007225 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 701177007226 motif II; other site 701177007227 polyol permease family; Region: 2A0118; TIGR00897 701177007228 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177007229 putative substrate translocation pore; other site 701177007230 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 701177007231 N- and C-terminal domain interface [polypeptide binding]; other site 701177007232 D-xylulose kinase; Region: XylB; TIGR01312 701177007233 active site 701177007234 MgATP binding site [chemical binding]; other site 701177007235 catalytic site [active] 701177007236 metal binding site [ion binding]; metal-binding site 701177007237 xylulose binding site [chemical binding]; other site 701177007238 homodimer interface [polypeptide binding]; other site 701177007239 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 701177007240 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 701177007241 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 701177007242 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 701177007243 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 701177007244 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 701177007245 Transcriptional regulators [Transcription]; Region: PurR; COG1609 701177007246 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 701177007247 DNA binding site [nucleotide binding] 701177007248 domain linker motif; other site 701177007249 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 701177007250 dimerization interface [polypeptide binding]; other site 701177007251 ligand binding site [chemical binding]; other site 701177007252 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 701177007253 classical (c) SDRs; Region: SDR_c; cd05233 701177007254 NAD(P) binding site [chemical binding]; other site 701177007255 active site 701177007256 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 701177007257 FGGY-family pentulose kinase; Region: 5C_CHO_kinase; TIGR01315 701177007258 N- and C-terminal domain interface [polypeptide binding]; other site 701177007259 active site 701177007260 MgATP binding site [chemical binding]; other site 701177007261 catalytic site [active] 701177007262 metal binding site [ion binding]; metal-binding site 701177007263 carbohydrate binding site [chemical binding]; other site 701177007264 putative homodimer interface [polypeptide binding]; other site 701177007265 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 701177007266 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 701177007267 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 701177007268 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 701177007269 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 701177007270 putative NAD(P) binding site [chemical binding]; other site 701177007271 catalytic Zn binding site [ion binding]; other site 701177007272 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 701177007273 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 701177007274 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 701177007275 active site 701177007276 P-loop; other site 701177007277 phosphorylation site [posttranslational modification] 701177007278 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 701177007279 active site 701177007280 phosphorylation site [posttranslational modification] 701177007281 D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052 701177007282 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 701177007283 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 701177007284 intersubunit interface [polypeptide binding]; other site 701177007285 active site 701177007286 zinc binding site [ion binding]; other site 701177007287 Na+ binding site [ion binding]; other site 701177007288 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 701177007289 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 701177007290 putative active site; other site 701177007291 catalytic residue [active] 701177007292 nucleoside transporter; Region: 2A0110; TIGR00889 701177007293 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177007294 putative substrate translocation pore; other site 701177007295 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 701177007296 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 701177007297 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 701177007298 substrate binding site [chemical binding]; other site 701177007299 ATP binding site [chemical binding]; other site 701177007300 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 701177007301 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 701177007302 DNA-binding site [nucleotide binding]; DNA binding site 701177007303 UTRA domain; Region: UTRA; pfam07702 701177007304 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 701177007305 YegX is an uncharacterized bacterial protein with a glycosyl hydrolase family 25 (GH25) catalytic domain that is similar in sequence to the CH-type (Chalaropsis-type) lysozymes of the GH25 family of endolysins; Region: GH25_YegX-like; cd06524 701177007306 active site 701177007307 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 701177007308 dimer interface [polypeptide binding]; other site 701177007309 substrate binding site [chemical binding]; other site 701177007310 ATP binding site [chemical binding]; other site 701177007311 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 701177007312 substrate binding site [chemical binding]; other site 701177007313 multimerization interface [polypeptide binding]; other site 701177007314 ATP binding site [chemical binding]; other site 701177007315 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 701177007316 putative metal binding site [ion binding]; other site 701177007317 putative homodimer interface [polypeptide binding]; other site 701177007318 putative homotetramer interface [polypeptide binding]; other site 701177007319 putative homodimer-homodimer interface [polypeptide binding]; other site 701177007320 putative allosteric switch controlling residues; other site 701177007321 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 701177007322 Predicted integral membrane protein [Function unknown]; Region: COG5455 701177007323 putative fimbrial-like adhesin protein StcD; Provisional; Region: PRK15252 701177007324 putative fimbrial biosynthesis regulatory protein; Provisional; Region: PRK15216 701177007325 Fimbrial protein; Region: Fimbrial; cl01416 701177007326 Protein of unknown function (DUF2574); Region: DUF2574; pfam10836 701177007327 antiporter inner membrane protein; Provisional; Region: PRK11670 701177007328 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 701177007329 Walker A motif; other site 701177007330 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 701177007331 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 701177007332 active site 701177007333 HIGH motif; other site 701177007334 KMSKS motif; other site 701177007335 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 701177007336 tRNA binding surface [nucleotide binding]; other site 701177007337 anticodon binding site; other site 701177007338 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 701177007339 dimer interface [polypeptide binding]; other site 701177007340 putative tRNA-binding site [nucleotide binding]; other site 701177007341 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 701177007342 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 701177007343 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 701177007344 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 701177007345 MoxR-like ATPases [General function prediction only]; Region: COG0714 701177007346 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 701177007347 Walker A motif; other site 701177007348 ATP binding site [chemical binding]; other site 701177007349 Walker B motif; other site 701177007350 arginine finger; other site 701177007351 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 701177007352 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 701177007353 metal ion-dependent adhesion site (MIDAS); other site 701177007354 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 701177007355 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 701177007356 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 701177007357 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 701177007358 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 701177007359 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 701177007360 active site 701177007361 phosphorylation site [posttranslational modification] 701177007362 intermolecular recognition site; other site 701177007363 dimerization interface [polypeptide binding]; other site 701177007364 LytTr DNA-binding domain; Region: LytTR; pfam04397 701177007365 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 701177007366 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 701177007367 GAF domain; Region: GAF; pfam01590 701177007368 Histidine kinase; Region: His_kinase; pfam06580 701177007369 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 701177007370 ATP binding site [chemical binding]; other site 701177007371 Mg2+ binding site [ion binding]; other site 701177007372 G-X-G motif; other site 701177007373 transcriptional regulator MirA; Provisional; Region: PRK15043 701177007374 Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763 701177007375 DNA binding residues [nucleotide binding] 701177007376 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 701177007377 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 701177007378 dimer interface [polypeptide binding]; other site 701177007379 conserved gate region; other site 701177007380 putative PBP binding loops; other site 701177007381 ABC-ATPase subunit interface; other site 701177007382 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 701177007383 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 701177007384 Walker A/P-loop; other site 701177007385 ATP binding site [chemical binding]; other site 701177007386 Q-loop/lid; other site 701177007387 ABC transporter signature motif; other site 701177007388 Walker B; other site 701177007389 D-loop; other site 701177007390 H-loop/switch region; other site 701177007391 CBS domain; Region: CBS; pfam00571 701177007392 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 701177007393 dimer interface [polypeptide binding]; other site 701177007394 conserved gate region; other site 701177007395 ABC-ATPase subunit interface; other site 701177007396 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 701177007397 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 701177007398 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 701177007399 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 701177007400 D-lactate dehydrogenase; Provisional; Region: PRK11183 701177007401 FAD binding domain; Region: FAD_binding_4; pfam01565 701177007402 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 701177007403 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 701177007404 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 701177007405 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 701177007406 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 701177007407 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 701177007408 oxidoreductase; Provisional; Region: PRK12743 701177007409 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 701177007410 NAD(P) binding site [chemical binding]; other site 701177007411 active site 701177007412 multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459 701177007413 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 701177007414 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 701177007415 FMN binding site [chemical binding]; other site 701177007416 active site 701177007417 catalytic residues [active] 701177007418 substrate binding site [chemical binding]; other site 701177007419 salicylate hydroxylase; Provisional; Region: PRK08163 701177007420 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 701177007421 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 701177007422 maleylacetoacetate isomerase; Region: maiA; TIGR01262 701177007423 C-terminal domain interface [polypeptide binding]; other site 701177007424 GSH binding site (G-site) [chemical binding]; other site 701177007425 putative dimer interface [polypeptide binding]; other site 701177007426 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 701177007427 dimer interface [polypeptide binding]; other site 701177007428 N-terminal domain interface [polypeptide binding]; other site 701177007429 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 701177007430 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 701177007431 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 701177007432 gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272 701177007433 Cupin domain; Region: Cupin_2; pfam07883 701177007434 Cupin domain; Region: Cupin_2; cl17218 701177007435 benzoate transport; Region: 2A0115; TIGR00895 701177007436 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177007437 putative substrate translocation pore; other site 701177007438 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 701177007439 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 701177007440 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 701177007441 dimerization interface [polypeptide binding]; other site 701177007442 hypothetical protein; Provisional; Region: PRK01821 701177007443 hypothetical protein; Provisional; Region: PRK10711 701177007444 cytidine deaminase; Provisional; Region: PRK09027 701177007445 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 701177007446 active site 701177007447 catalytic motif [active] 701177007448 Zn binding site [ion binding]; other site 701177007449 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 701177007450 active site 701177007451 catalytic motif [active] 701177007452 Zn binding site [ion binding]; other site 701177007453 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 701177007454 putative active site [active] 701177007455 Protein of unknown function (DUF2542); Region: DUF2542; pfam10808 701177007456 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 701177007457 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 701177007458 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 701177007459 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 701177007460 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 701177007461 homodimer interface [polypeptide binding]; other site 701177007462 active site 701177007463 FMN binding site [chemical binding]; other site 701177007464 substrate binding site [chemical binding]; other site 701177007465 4Fe-4S binding domain; Region: Fer4; pfam00037 701177007466 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 701177007467 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 701177007468 TM-ABC transporter signature motif; other site 701177007469 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 701177007470 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 701177007471 Walker A/P-loop; other site 701177007472 ATP binding site [chemical binding]; other site 701177007473 Q-loop/lid; other site 701177007474 ABC transporter signature motif; other site 701177007475 Walker B; other site 701177007476 D-loop; other site 701177007477 H-loop/switch region; other site 701177007478 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 701177007479 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 701177007480 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 701177007481 ligand binding site [chemical binding]; other site 701177007482 calcium binding site [ion binding]; other site 701177007483 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 701177007484 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 701177007485 DNA binding site [nucleotide binding] 701177007486 domain linker motif; other site 701177007487 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 701177007488 dimerization interface (closed form) [polypeptide binding]; other site 701177007489 ligand binding site [chemical binding]; other site 701177007490 Predicted membrane protein [Function unknown]; Region: COG2311 701177007491 hypothetical protein; Provisional; Region: PRK10835 701177007492 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 701177007493 homodecamer interface [polypeptide binding]; other site 701177007494 GTP cyclohydrolase I; Provisional; Region: PLN03044 701177007495 active site 701177007496 putative catalytic site residues [active] 701177007497 zinc binding site [ion binding]; other site 701177007498 GTP-CH-I/GFRP interaction surface; other site 701177007499 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 701177007500 S-formylglutathione hydrolase; Region: PLN02442 701177007501 catecholate siderophore receptor CirA; Provisional; Region: PRK10064 701177007502 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 701177007503 N-terminal plug; other site 701177007504 ligand-binding site [chemical binding]; other site 701177007505 lysine transporter; Provisional; Region: PRK10836 701177007506 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 701177007507 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 701177007508 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 701177007509 putative dimerization interface [polypeptide binding]; other site 701177007510 conserved hypothetical integral membrane protein; Region: TIGR00698 701177007511 endonuclease IV; Provisional; Region: PRK01060 701177007512 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 701177007513 AP (apurinic/apyrimidinic) site pocket; other site 701177007514 DNA interaction; other site 701177007515 Metal-binding active site; metal-binding site 701177007516 putative kinase; Provisional; Region: PRK09954 701177007517 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 701177007518 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 701177007519 substrate binding site [chemical binding]; other site 701177007520 ATP binding site [chemical binding]; other site 701177007521 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 701177007522 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 701177007523 Nucleoside recognition; Region: Gate; pfam07670 701177007524 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 701177007525 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 701177007526 active site 701177007527 tetramer interface [polypeptide binding]; other site 701177007528 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 701177007529 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 701177007530 ligand binding site [chemical binding]; other site 701177007531 flexible hinge region; other site 701177007532 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 701177007533 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 701177007534 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 701177007535 Nucleoside recognition; Region: Gate; pfam07670 701177007536 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 701177007537 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 701177007538 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 701177007539 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 701177007540 substrate binding site [chemical binding]; other site 701177007541 ATP binding site [chemical binding]; other site 701177007542 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 701177007543 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 701177007544 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 701177007545 active site 701177007546 P-loop; other site 701177007547 phosphorylation site [posttranslational modification] 701177007548 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 701177007549 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 701177007550 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 701177007551 putative substrate binding site [chemical binding]; other site 701177007552 putative ATP binding site [chemical binding]; other site 701177007553 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 701177007554 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 701177007555 active site 701177007556 phosphorylation site [posttranslational modification] 701177007557 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 701177007558 dimerization domain swap beta strand [polypeptide binding]; other site 701177007559 regulatory protein interface [polypeptide binding]; other site 701177007560 active site 701177007561 regulatory phosphorylation site [posttranslational modification]; other site 701177007562 sugar efflux transporter B; Provisional; Region: PRK15011 701177007563 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177007564 putative substrate translocation pore; other site 701177007565 elongation factor P; Provisional; Region: PRK04542 701177007566 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 701177007567 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 701177007568 RNA binding site [nucleotide binding]; other site 701177007569 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 701177007570 RNA binding site [nucleotide binding]; other site 701177007571 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 701177007572 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 701177007573 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 701177007574 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 701177007575 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 701177007576 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 701177007577 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 701177007578 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 701177007579 active site 701177007580 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 701177007581 NlpC/P60 family; Region: NLPC_P60; pfam00877 701177007582 phage resistance protein; Provisional; Region: PRK10551 701177007583 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 701177007584 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 701177007585 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 701177007586 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 701177007587 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 701177007588 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 701177007589 dimer interface [polypeptide binding]; other site 701177007590 conserved gate region; other site 701177007591 putative PBP binding loops; other site 701177007592 ABC-ATPase subunit interface; other site 701177007593 microcin C ABC transporter permease; Provisional; Region: PRK15021 701177007594 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 701177007595 dimer interface [polypeptide binding]; other site 701177007596 conserved gate region; other site 701177007597 ABC-ATPase subunit interface; other site 701177007598 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 701177007599 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 701177007600 Walker A/P-loop; other site 701177007601 ATP binding site [chemical binding]; other site 701177007602 Q-loop/lid; other site 701177007603 ABC transporter signature motif; other site 701177007604 Walker B; other site 701177007605 D-loop; other site 701177007606 H-loop/switch region; other site 701177007607 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 701177007608 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 701177007609 Walker A/P-loop; other site 701177007610 ATP binding site [chemical binding]; other site 701177007611 Q-loop/lid; other site 701177007612 ABC transporter signature motif; other site 701177007613 Walker B; other site 701177007614 D-loop; other site 701177007615 H-loop/switch region; other site 701177007616 hypothetical protein; Provisional; Region: PRK11835 701177007617 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177007618 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 701177007619 putative substrate translocation pore; other site 701177007620 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 701177007621 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 701177007622 RNA binding surface [nucleotide binding]; other site 701177007623 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 701177007624 active site 701177007625 uracil binding [chemical binding]; other site 701177007626 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 701177007627 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 701177007628 ATP binding site [chemical binding]; other site 701177007629 putative Mg++ binding site [ion binding]; other site 701177007630 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 701177007631 nucleotide binding region [chemical binding]; other site 701177007632 ATP-binding site [chemical binding]; other site 701177007633 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 701177007634 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 701177007635 5S rRNA interface [nucleotide binding]; other site 701177007636 CTC domain interface [polypeptide binding]; other site 701177007637 L16 interface [polypeptide binding]; other site 701177007638 Nucleoid-associated protein [General function prediction only]; Region: COG3081 701177007639 nucleoid-associated protein NdpA; Validated; Region: PRK00378 701177007640 hypothetical protein; Provisional; Region: PRK13689 701177007641 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 701177007642 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 701177007643 Sulfatase; Region: Sulfatase; pfam00884 701177007644 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 701177007645 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 701177007646 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 701177007647 Autotransporter beta-domain; Region: Autotransporter; pfam03797 701177007648 transcriptional regulator NarP; Provisional; Region: PRK10403 701177007649 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 701177007650 active site 701177007651 phosphorylation site [posttranslational modification] 701177007652 intermolecular recognition site; other site 701177007653 dimerization interface [polypeptide binding]; other site 701177007654 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 701177007655 DNA binding residues [nucleotide binding] 701177007656 dimerization interface [polypeptide binding]; other site 701177007657 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 701177007658 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 701177007659 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 701177007660 binding surface 701177007661 TPR motif; other site 701177007662 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 701177007663 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 701177007664 catalytic residues [active] 701177007665 central insert; other site 701177007666 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 701177007667 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 701177007668 heme exporter protein CcmC; Region: ccmC; TIGR01191 701177007669 heme exporter protein CcmB; Region: ccmB; TIGR01190 701177007670 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 701177007671 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 701177007672 Walker A/P-loop; other site 701177007673 ATP binding site [chemical binding]; other site 701177007674 Q-loop/lid; other site 701177007675 ABC transporter signature motif; other site 701177007676 Walker B; other site 701177007677 D-loop; other site 701177007678 H-loop/switch region; other site 701177007679 cytochrome c-type protein NapC; Provisional; Region: PRK10617 701177007680 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 701177007681 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 701177007682 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 701177007683 4Fe-4S binding domain; Region: Fer4_5; pfam12801 701177007684 4Fe-4S binding domain; Region: Fer4; cl02805 701177007685 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 701177007686 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 701177007687 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 701177007688 [4Fe-4S] binding site [ion binding]; other site 701177007689 molybdopterin cofactor binding site; other site 701177007690 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 701177007691 molybdopterin cofactor binding site; other site 701177007692 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 701177007693 ferredoxin-type protein; Provisional; Region: PRK10194 701177007694 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 701177007695 secondary substrate binding site; other site 701177007696 primary substrate binding site; other site 701177007697 inhibition loop; other site 701177007698 dimerization interface [polypeptide binding]; other site 701177007699 malate:quinone oxidoreductase; Validated; Region: PRK05257 701177007700 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 701177007701 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 701177007702 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 701177007703 Walker A/P-loop; other site 701177007704 ATP binding site [chemical binding]; other site 701177007705 Q-loop/lid; other site 701177007706 ABC transporter signature motif; other site 701177007707 Walker B; other site 701177007708 D-loop; other site 701177007709 H-loop/switch region; other site 701177007710 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 701177007711 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 701177007712 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 701177007713 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 701177007714 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 701177007715 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 701177007716 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 701177007717 DNA binding site [nucleotide binding] 701177007718 active site 701177007719 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 701177007720 ApbE family; Region: ApbE; pfam02424 701177007721 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 701177007722 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 701177007723 trimer interface [polypeptide binding]; other site 701177007724 eyelet of channel; other site 701177007725 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 701177007726 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 701177007727 ATP binding site [chemical binding]; other site 701177007728 G-X-G motif; other site 701177007729 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 701177007730 putative binding surface; other site 701177007731 active site 701177007732 transcriptional regulator RcsB; Provisional; Region: PRK10840 701177007733 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 701177007734 active site 701177007735 phosphorylation site [posttranslational modification] 701177007736 intermolecular recognition site; other site 701177007737 dimerization interface [polypeptide binding]; other site 701177007738 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 701177007739 DNA binding residues [nucleotide binding] 701177007740 dimerization interface [polypeptide binding]; other site 701177007741 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 701177007742 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 701177007743 dimer interface [polypeptide binding]; other site 701177007744 phosphorylation site [posttranslational modification] 701177007745 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 701177007746 ATP binding site [chemical binding]; other site 701177007747 Mg2+ binding site [ion binding]; other site 701177007748 G-X-G motif; other site 701177007749 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 701177007750 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 701177007751 active site 701177007752 phosphorylation site [posttranslational modification] 701177007753 intermolecular recognition site; other site 701177007754 dimerization interface [polypeptide binding]; other site 701177007755 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 701177007756 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 701177007757 Transposase; Region: DEDD_Tnp_IS110; pfam01548 701177007758 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 701177007759 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3234 701177007760 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4685 701177007761 DNA gyrase subunit A; Validated; Region: PRK05560 701177007762 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 701177007763 CAP-like domain; other site 701177007764 active site 701177007765 primary dimer interface [polypeptide binding]; other site 701177007766 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 701177007767 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 701177007768 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 701177007769 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 701177007770 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 701177007771 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 701177007772 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 701177007773 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 701177007774 S-adenosylmethionine binding site [chemical binding]; other site 701177007775 adhesin; Provisional; Region: PRK09752 701177007776 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 701177007777 Autotransporter beta-domain; Region: Autotransporter; pfam03797 701177007778 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 701177007779 ATP cone domain; Region: ATP-cone; pfam03477 701177007780 Class I ribonucleotide reductase; Region: RNR_I; cd01679 701177007781 active site 701177007782 dimer interface [polypeptide binding]; other site 701177007783 catalytic residues [active] 701177007784 effector binding site; other site 701177007785 R2 peptide binding site; other site 701177007786 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 701177007787 dimer interface [polypeptide binding]; other site 701177007788 putative radical transfer pathway; other site 701177007789 diiron center [ion binding]; other site 701177007790 tyrosyl radical; other site 701177007791 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 701177007792 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 701177007793 catalytic loop [active] 701177007794 iron binding site [ion binding]; other site 701177007795 hypothetical protein; Provisional; Region: PRK09902 701177007796 Transcriptional regulator [Transcription]; Region: LysR; COG0583 701177007797 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 701177007798 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 701177007799 dimerization interface [polypeptide binding]; other site 701177007800 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 701177007801 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 701177007802 active site 701177007803 catalytic site [active] 701177007804 metal binding site [ion binding]; metal-binding site 701177007805 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 701177007806 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177007807 putative substrate translocation pore; other site 701177007808 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 701177007809 hydroxyglutarate oxidase; Provisional; Region: PRK11728 701177007810 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 701177007811 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 701177007812 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 701177007813 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 701177007814 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 701177007815 Cysteine-rich domain; Region: CCG; pfam02754 701177007816 Cysteine-rich domain; Region: CCG; pfam02754 701177007817 hypothetical protein; Provisional; Region: PRK09956 701177007818 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 701177007819 2-keto-3-deoxy-L-rhamnonate aldolase; Provisional; Region: PRK10128 701177007820 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 701177007821 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177007822 putative substrate translocation pore; other site 701177007823 L-rhamnonate dehydratase; Provisional; Region: PRK15440 701177007824 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 701177007825 putative active site pocket [active] 701177007826 putative metal binding site [ion binding]; other site 701177007827 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 701177007828 Transcriptional regulator [Transcription]; Region: IclR; COG1414 701177007829 Bacterial transcriptional regulator; Region: IclR; pfam01614 701177007830 hypothetical protein; Provisional; Region: PRK03673 701177007831 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 701177007832 putative MPT binding site; other site 701177007833 Competence-damaged protein; Region: CinA; cl00666 701177007834 YfaZ precursor; Region: YfaZ; pfam07437 701177007835 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 701177007836 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 701177007837 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 701177007838 catalytic core [active] 701177007839 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 701177007840 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 701177007841 inhibitor-cofactor binding pocket; inhibition site 701177007842 pyridoxal 5'-phosphate binding site [chemical binding]; other site 701177007843 catalytic residue [active] 701177007844 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 701177007845 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 701177007846 Ligand binding site; other site 701177007847 Putative Catalytic site; other site 701177007848 DXD motif; other site 701177007849 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 701177007850 ArnA, N-terminal formyltransferase domain; Region: FMT_core_ArnA_N; cd08644 701177007851 substrate binding site [chemical binding]; other site 701177007852 cosubstrate binding site; other site 701177007853 catalytic site [active] 701177007854 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 701177007855 active site 701177007856 hexamer interface [polypeptide binding]; other site 701177007857 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 701177007858 NAD binding site [chemical binding]; other site 701177007859 substrate binding site [chemical binding]; other site 701177007860 active site 701177007861 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 701177007862 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 701177007863 putative active site [active] 701177007864 putative catalytic site [active] 701177007865 putative Zn binding site [ion binding]; other site 701177007866 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 701177007867 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 701177007868 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 701177007869 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 701177007870 signal transduction protein PmrD; Provisional; Region: PRK15450 701177007871 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 701177007872 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 701177007873 acyl-activating enzyme (AAE) consensus motif; other site 701177007874 putative AMP binding site [chemical binding]; other site 701177007875 putative active site [active] 701177007876 putative CoA binding site [chemical binding]; other site 701177007877 O-succinylbenzoate synthase; Provisional; Region: PRK05105 701177007878 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 701177007879 active site 701177007880 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 701177007881 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 701177007882 substrate binding site [chemical binding]; other site 701177007883 oxyanion hole (OAH) forming residues; other site 701177007884 trimer interface [polypeptide binding]; other site 701177007885 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 701177007886 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 701177007887 nucleophilic elbow; other site 701177007888 catalytic triad; other site 701177007889 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 701177007890 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 701177007891 dimer interface [polypeptide binding]; other site 701177007892 tetramer interface [polypeptide binding]; other site 701177007893 PYR/PP interface [polypeptide binding]; other site 701177007894 TPP binding site [chemical binding]; other site 701177007895 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 701177007896 TPP-binding site; other site 701177007897 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 701177007898 isochorismate synthases; Region: isochor_syn; TIGR00543 701177007899 hypothetical protein; Provisional; Region: PRK10404 701177007900 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 701177007901 Coenzyme A binding pocket [chemical binding]; other site 701177007902 ribonuclease BN; Region: true_RNase_BN; TIGR02649 701177007903 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 701177007904 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 701177007905 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 701177007906 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 701177007907 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 701177007908 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 701177007909 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 701177007910 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 701177007911 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 701177007912 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 701177007913 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 701177007914 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 701177007915 4Fe-4S binding domain; Region: Fer4; pfam00037 701177007916 4Fe-4S binding domain; Region: Fer4; pfam00037 701177007917 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 701177007918 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 701177007919 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 701177007920 catalytic loop [active] 701177007921 iron binding site [ion binding]; other site 701177007922 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 701177007923 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 701177007924 [4Fe-4S] binding site [ion binding]; other site 701177007925 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 701177007926 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 701177007927 SLBB domain; Region: SLBB; pfam10531 701177007928 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 701177007929 NADH dehydrogenase subunit E; Validated; Region: PRK07539 701177007930 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 701177007931 putative dimer interface [polypeptide binding]; other site 701177007932 [2Fe-2S] cluster binding site [ion binding]; other site 701177007933 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 701177007934 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 701177007935 NADH dehydrogenase subunit D; Validated; Region: PRK06075 701177007936 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 701177007937 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 701177007938 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 701177007939 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 701177007940 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 701177007941 putative dimerization interface [polypeptide binding]; other site 701177007942 aminotransferase AlaT; Validated; Region: PRK09265 701177007943 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 701177007944 pyridoxal 5'-phosphate binding site [chemical binding]; other site 701177007945 homodimer interface [polypeptide binding]; other site 701177007946 catalytic residue [active] 701177007947 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 701177007948 Zn2+ binding site [ion binding]; other site 701177007949 Mg2+ binding site [ion binding]; other site 701177007950 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 701177007951 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 701177007952 TrkA-C domain; Region: TrkA_C; pfam02080 701177007953 TrkA-C domain; Region: TrkA_C; pfam02080 701177007954 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 701177007955 putative phosphatase; Provisional; Region: PRK11587 701177007956 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 701177007957 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 701177007958 motif II; other site 701177007959 hypothetical protein; Validated; Region: PRK05445 701177007960 hypothetical protein; Provisional; Region: PRK01816 701177007961 propionate/acetate kinase; Provisional; Region: PRK12379 701177007962 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 701177007963 phosphate acetyltransferase; Reviewed; Region: PRK05632 701177007964 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 701177007965 DRTGG domain; Region: DRTGG; pfam07085 701177007966 phosphate acetyltransferase; Region: pta; TIGR00651 701177007967 hypothetical protein; Provisional; Region: PRK11588 701177007968 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 701177007969 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 701177007970 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 701177007971 nudix motif; other site 701177007972 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 701177007973 active site 701177007974 metal binding site [ion binding]; metal-binding site 701177007975 homotetramer interface [polypeptide binding]; other site 701177007976 glutathione S-transferase; Provisional; Region: PRK15113 701177007977 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 701177007978 C-terminal domain interface [polypeptide binding]; other site 701177007979 GSH binding site (G-site) [chemical binding]; other site 701177007980 dimer interface [polypeptide binding]; other site 701177007981 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 701177007982 N-terminal domain interface [polypeptide binding]; other site 701177007983 putative dimer interface [polypeptide binding]; other site 701177007984 putative substrate binding pocket (H-site) [chemical binding]; other site 701177007985 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 701177007986 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 701177007987 C-terminal domain interface [polypeptide binding]; other site 701177007988 GSH binding site (G-site) [chemical binding]; other site 701177007989 dimer interface [polypeptide binding]; other site 701177007990 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 701177007991 N-terminal domain interface [polypeptide binding]; other site 701177007992 putative dimer interface [polypeptide binding]; other site 701177007993 active site 701177007994 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 701177007995 homooctamer interface [polypeptide binding]; other site 701177007996 active site 701177007997 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 701177007998 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 701177007999 putative NAD(P) binding site [chemical binding]; other site 701177008000 putative active site [active] 701177008001 putative transposase; Provisional; Region: PRK09857 701177008002 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 701177008003 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 701177008004 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 701177008005 Walker A/P-loop; other site 701177008006 ATP binding site [chemical binding]; other site 701177008007 Q-loop/lid; other site 701177008008 ABC transporter signature motif; other site 701177008009 Walker B; other site 701177008010 D-loop; other site 701177008011 H-loop/switch region; other site 701177008012 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 701177008013 dimer interface [polypeptide binding]; other site 701177008014 conserved gate region; other site 701177008015 putative PBP binding loops; other site 701177008016 ABC-ATPase subunit interface; other site 701177008017 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 701177008018 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 701177008019 dimer interface [polypeptide binding]; other site 701177008020 conserved gate region; other site 701177008021 putative PBP binding loops; other site 701177008022 ABC-ATPase subunit interface; other site 701177008023 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 701177008024 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 701177008025 substrate binding pocket [chemical binding]; other site 701177008026 membrane-bound complex binding site; other site 701177008027 hinge residues; other site 701177008028 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 701177008029 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 701177008030 substrate binding pocket [chemical binding]; other site 701177008031 membrane-bound complex binding site; other site 701177008032 hinge residues; other site 701177008033 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 701177008034 Flavoprotein; Region: Flavoprotein; pfam02441 701177008035 amidophosphoribosyltransferase; Provisional; Region: PRK09246 701177008036 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 701177008037 active site 701177008038 tetramer interface [polypeptide binding]; other site 701177008039 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 701177008040 active site 701177008041 colicin V production protein; Provisional; Region: PRK10845 701177008042 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 701177008043 cell division protein DedD; Provisional; Region: PRK11633 701177008044 Sporulation related domain; Region: SPOR; pfam05036 701177008045 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 701177008046 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 701177008047 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 701177008048 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 701177008049 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 701177008050 hypothetical protein; Provisional; Region: PRK10847 701177008051 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 701177008052 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 701177008053 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 701177008054 dimerization interface 3.5A [polypeptide binding]; other site 701177008055 active site 701177008056 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 701177008057 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 701177008058 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 701177008059 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 701177008060 ligand binding site [chemical binding]; other site 701177008061 NAD binding site [chemical binding]; other site 701177008062 catalytic site [active] 701177008063 homodimer interface [polypeptide binding]; other site 701177008064 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 701177008065 putative transporter; Provisional; Region: PRK12382 701177008066 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177008067 putative substrate translocation pore; other site 701177008068 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 701177008069 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 701177008070 dimer interface [polypeptide binding]; other site 701177008071 active site 701177008072 Uncharacterized conserved protein [Function unknown]; Region: COG4121 701177008073 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 701177008074 YfcL protein; Region: YfcL; pfam08891 701177008075 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 701177008076 hypothetical protein; Provisional; Region: PRK10621 701177008077 Predicted permeases [General function prediction only]; Region: COG0730 701177008078 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 701177008079 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 701177008080 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 701177008081 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 701177008082 Tetramer interface [polypeptide binding]; other site 701177008083 active site 701177008084 FMN-binding site [chemical binding]; other site 701177008085 HemK family putative methylases; Region: hemK_fam; TIGR00536 701177008086 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 701177008087 S-adenosylmethionine binding site [chemical binding]; other site 701177008088 hypothetical protein; Provisional; Region: PRK04946 701177008089 Smr domain; Region: Smr; pfam01713 701177008090 Protein of unknown function (DUF2544); Region: DUF2544; pfam11245 701177008091 Fimbrial protein; Region: Fimbrial; cl01416 701177008092 Fimbrial protein; Region: Fimbrial; cl01416 701177008093 Fimbrial protein; Region: Fimbrial; cl01416 701177008094 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 701177008095 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 701177008096 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 701177008097 PapC N-terminal domain; Region: PapC_N; pfam13954 701177008098 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 701177008099 PapC C-terminal domain; Region: PapC_C; pfam13953 701177008100 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 701177008101 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 701177008102 catalytic core [active] 701177008103 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 701177008104 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 701177008105 substrate binding site [chemical binding]; other site 701177008106 oxyanion hole (OAH) forming residues; other site 701177008107 trimer interface [polypeptide binding]; other site 701177008108 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 701177008109 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 701177008110 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 701177008111 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 701177008112 dimer interface [polypeptide binding]; other site 701177008113 active site 701177008114 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 701177008115 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 701177008116 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 701177008117 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 701177008118 integrase; Provisional; Region: PRK09692 701177008119 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 701177008120 active site 701177008121 Int/Topo IB signature motif; other site 701177008122 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 701177008123 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 701177008124 Protein of unknown function (DUF2824); Region: DUF2824; cl10279 701177008125 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 701177008126 Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient...; Region: SR_Res_par; cd03767 701177008127 catalytic residues [active] 701177008128 catalytic nucleophile [active] 701177008129 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 701177008130 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177008131 putative substrate translocation pore; other site 701177008132 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 701177008133 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 701177008134 putative substrate binding site [chemical binding]; other site 701177008135 putative ATP binding site [chemical binding]; other site 701177008136 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 701177008137 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 701177008138 substrate binding [chemical binding]; other site 701177008139 active site 701177008140 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 701177008141 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 701177008142 DNA binding site [nucleotide binding] 701177008143 domain linker motif; other site 701177008144 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 701177008145 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 701177008146 putative dimerization interface [polypeptide binding]; other site 701177008147 putative ligand binding site [chemical binding]; other site 701177008148 fructuronate transporter; Provisional; Region: PRK10034; cl15264 701177008149 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 701177008150 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 701177008151 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 701177008152 catalytic residue [active] 701177008153 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 701177008154 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177008155 putative substrate translocation pore; other site 701177008156 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177008157 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 701177008158 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 701177008159 HlyD family secretion protein; Region: HlyD_3; pfam13437 701177008160 DNA-binding transcriptional activator EvgA; Provisional; Region: PRK09958 701177008161 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 701177008162 active site 701177008163 phosphorylation site [posttranslational modification] 701177008164 intermolecular recognition site; other site 701177008165 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 701177008166 DNA binding residues [nucleotide binding] 701177008167 dimerization interface [polypeptide binding]; other site 701177008168 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 701177008169 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 701177008170 substrate binding pocket [chemical binding]; other site 701177008171 membrane-bound complex binding site; other site 701177008172 hinge residues; other site 701177008173 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 701177008174 substrate binding pocket [chemical binding]; other site 701177008175 membrane-bound complex binding site; other site 701177008176 hinge residues; other site 701177008177 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 701177008178 dimer interface [polypeptide binding]; other site 701177008179 phosphorylation site [posttranslational modification] 701177008180 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 701177008181 ATP binding site [chemical binding]; other site 701177008182 Mg2+ binding site [ion binding]; other site 701177008183 G-X-G motif; other site 701177008184 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 701177008185 active site 701177008186 phosphorylation site [posttranslational modification] 701177008187 intermolecular recognition site; other site 701177008188 dimerization interface [polypeptide binding]; other site 701177008189 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 701177008190 putative binding surface; other site 701177008191 active site 701177008192 putative CoA-transferase; Provisional; Region: PRK11430 701177008193 CoA-transferase family III; Region: CoA_transf_3; pfam02515 701177008194 putative transporter YfdV; Provisional; Region: PRK09903 701177008195 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 701177008196 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 701177008197 PYR/PP interface [polypeptide binding]; other site 701177008198 dimer interface [polypeptide binding]; other site 701177008199 TPP binding site [chemical binding]; other site 701177008200 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 701177008201 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 701177008202 TPP-binding site; other site 701177008203 dimer interface [polypeptide binding]; other site 701177008204 formyl-coenzyme A transferase; Provisional; Region: PRK05398 701177008205 CoA-transferase family III; Region: CoA_transf_3; pfam02515 701177008206 hypothetical protein; Provisional; Region: PRK10316 701177008207 YfdX protein; Region: YfdX; pfam10938 701177008208 Protein of unknown function (DUF2545); Region: DUF2545; pfam10810 701177008209 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 701177008210 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 701177008211 putative acyl-acceptor binding pocket; other site 701177008212 aminotransferase; Validated; Region: PRK08175 701177008213 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 701177008214 pyridoxal 5'-phosphate binding site [chemical binding]; other site 701177008215 homodimer interface [polypeptide binding]; other site 701177008216 catalytic residue [active] 701177008217 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 701177008218 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 701177008219 GAF domain; Region: GAF; pfam01590 701177008220 Histidine kinase; Region: His_kinase; pfam06580 701177008221 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 701177008222 ATP binding site [chemical binding]; other site 701177008223 Mg2+ binding site [ion binding]; other site 701177008224 G-X-G motif; other site 701177008225 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 701177008226 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 701177008227 active site 701177008228 phosphorylation site [posttranslational modification] 701177008229 intermolecular recognition site; other site 701177008230 dimerization interface [polypeptide binding]; other site 701177008231 LytTr DNA-binding domain; Region: LytTR; pfam04397 701177008232 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 701177008233 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 701177008234 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 701177008235 dimerization domain swap beta strand [polypeptide binding]; other site 701177008236 regulatory protein interface [polypeptide binding]; other site 701177008237 active site 701177008238 regulatory phosphorylation site [posttranslational modification]; other site 701177008239 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 701177008240 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 701177008241 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 701177008242 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 701177008243 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 701177008244 active site 701177008245 phosphorylation site [posttranslational modification] 701177008246 exoaminopeptidase; Provisional; Region: PRK09961 701177008247 M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638 701177008248 oligomer interface [polypeptide binding]; other site 701177008249 active site 701177008250 metal binding site [ion binding]; metal-binding site 701177008251 aminopeptidase; Provisional; Region: PRK09795 701177008252 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 701177008253 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 701177008254 active site 701177008255 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 701177008256 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 701177008257 active site 701177008258 P-loop; other site 701177008259 phosphorylation site [posttranslational modification] 701177008260 glucokinase, proteobacterial type; Region: glk; TIGR00749 701177008261 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 701177008262 nucleotide binding site [chemical binding]; other site 701177008263 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 701177008264 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 701177008265 Cl- selectivity filter; other site 701177008266 Cl- binding residues [ion binding]; other site 701177008267 pore gating glutamate residue; other site 701177008268 dimer interface [polypeptide binding]; other site 701177008269 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 701177008270 manganese transport protein MntH; Reviewed; Region: PRK00701 701177008271 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 701177008272 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 701177008273 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 701177008274 Nucleoside recognition; Region: Gate; pfam07670 701177008275 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 701177008276 MASE1; Region: MASE1; pfam05231 701177008277 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 701177008278 diguanylate cyclase; Region: GGDEF; smart00267 701177008279 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 701177008280 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 701177008281 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 701177008282 salt bridge; other site 701177008283 non-specific DNA binding site [nucleotide binding]; other site 701177008284 sequence-specific DNA binding site [nucleotide binding]; other site 701177008285 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 701177008286 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 701177008287 Probable transposase; Region: OrfB_IS605; pfam01385 701177008288 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 701177008289 Transposase IS200 like; Region: Y1_Tnp; pfam01797 701177008290 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 701177008291 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 701177008292 active site 701177008293 HIGH motif; other site 701177008294 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 701177008295 active site 701177008296 KMSKS motif; other site 701177008297 Transcriptional regulator [Transcription]; Region: LysR; COG0583 701177008298 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 701177008299 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 701177008300 putative dimerization interface [polypeptide binding]; other site 701177008301 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 701177008302 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 701177008303 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 701177008304 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 701177008305 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 701177008306 nucleotide binding pocket [chemical binding]; other site 701177008307 K-X-D-G motif; other site 701177008308 catalytic site [active] 701177008309 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 701177008310 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 701177008311 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 701177008312 Dimer interface [polypeptide binding]; other site 701177008313 BRCT sequence motif; other site 701177008314 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 701177008315 cell division protein ZipA; Provisional; Region: PRK03427 701177008316 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 701177008317 FtsZ protein binding site [polypeptide binding]; other site 701177008318 putative sulfate transport protein CysZ; Validated; Region: PRK04949 701177008319 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 701177008320 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 701177008321 dimer interface [polypeptide binding]; other site 701177008322 pyridoxal 5'-phosphate binding site [chemical binding]; other site 701177008323 catalytic residue [active] 701177008324 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 701177008325 dimerization domain swap beta strand [polypeptide binding]; other site 701177008326 regulatory protein interface [polypeptide binding]; other site 701177008327 active site 701177008328 regulatory phosphorylation site [posttranslational modification]; other site 701177008329 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 701177008330 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 701177008331 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 701177008332 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 701177008333 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 701177008334 HPr interaction site; other site 701177008335 glycerol kinase (GK) interaction site [polypeptide binding]; other site 701177008336 active site 701177008337 phosphorylation site [posttranslational modification] 701177008338 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 701177008339 dimer interface [polypeptide binding]; other site 701177008340 pyridoxamine kinase; Validated; Region: PRK05756 701177008341 pyridoxal binding site [chemical binding]; other site 701177008342 ATP binding site [chemical binding]; other site 701177008343 hypothetical protein; Provisional; Region: PRK10318 701177008344 cysteine synthase B; Region: cysM; TIGR01138 701177008345 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 701177008346 dimer interface [polypeptide binding]; other site 701177008347 pyridoxal 5'-phosphate binding site [chemical binding]; other site 701177008348 catalytic residue [active] 701177008349 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 701177008350 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 701177008351 Walker A/P-loop; other site 701177008352 ATP binding site [chemical binding]; other site 701177008353 Q-loop/lid; other site 701177008354 ABC transporter signature motif; other site 701177008355 Walker B; other site 701177008356 D-loop; other site 701177008357 H-loop/switch region; other site 701177008358 TOBE-like domain; Region: TOBE_3; pfam12857 701177008359 sulfate transport protein; Provisional; Region: cysT; CHL00187 701177008360 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 701177008361 dimer interface [polypeptide binding]; other site 701177008362 conserved gate region; other site 701177008363 putative PBP binding loops; other site 701177008364 ABC-ATPase subunit interface; other site 701177008365 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 701177008366 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 701177008367 dimer interface [polypeptide binding]; other site 701177008368 conserved gate region; other site 701177008369 putative PBP binding loops; other site 701177008370 ABC-ATPase subunit interface; other site 701177008371 thiosulfate transporter subunit; Provisional; Region: PRK10852 701177008372 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 701177008373 short chain dehydrogenase; Provisional; Region: PRK08226 701177008374 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 701177008375 NAD binding site [chemical binding]; other site 701177008376 homotetramer interface [polypeptide binding]; other site 701177008377 homodimer interface [polypeptide binding]; other site 701177008378 active site 701177008379 transcriptional regulator MurR; Provisional; Region: PRK15482 701177008380 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 701177008381 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 701177008382 putative active site [active] 701177008383 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 701177008384 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 701177008385 putative active site [active] 701177008386 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 701177008387 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 701177008388 active site turn [active] 701177008389 phosphorylation site [posttranslational modification] 701177008390 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 701177008391 putative periplasmic esterase; Provisional; Region: PRK03642 701177008392 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 701177008393 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 701177008394 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 701177008395 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 701177008396 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 701177008397 putative acetyltransferase; Provisional; Region: PRK03624 701177008398 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 701177008399 Coenzyme A binding pocket [chemical binding]; other site 701177008400 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 701177008401 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 701177008402 active site 701177008403 metal binding site [ion binding]; metal-binding site 701177008404 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 701177008405 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 701177008406 transcriptional regulator EutR; Provisional; Region: PRK10130 701177008407 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 701177008408 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 701177008409 carboxysome structural protein EutK; Provisional; Region: PRK15466 701177008410 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 701177008411 Hexamer interface [polypeptide binding]; other site 701177008412 Hexagonal pore residue; other site 701177008413 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 701177008414 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 701177008415 putative hexamer interface [polypeptide binding]; other site 701177008416 putative hexagonal pore; other site 701177008417 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 701177008418 putative hexamer interface [polypeptide binding]; other site 701177008419 putative hexagonal pore; other site 701177008420 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 701177008421 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 701177008422 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 701177008423 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 701177008424 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 701177008425 ethanol dehydrogenase EutG; Provisional; Region: PRK15454 701177008426 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 701177008427 active site 701177008428 metal binding site [ion binding]; metal-binding site 701177008429 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 701177008430 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 701177008431 nucleotide binding site [chemical binding]; other site 701177008432 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 701177008433 putative catalytic cysteine [active] 701177008434 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 701177008435 Hexamer/Pentamer interface [polypeptide binding]; other site 701177008436 central pore; other site 701177008437 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 701177008438 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 701177008439 Hexamer interface [polypeptide binding]; other site 701177008440 Putative hexagonal pore residue; other site 701177008441 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 701177008442 ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020 701177008443 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 701177008444 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766 701177008445 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 701177008446 G1 box; other site 701177008447 GTP/Mg2+ binding site [chemical binding]; other site 701177008448 G2 box; other site 701177008449 Switch I region; other site 701177008450 G3 box; other site 701177008451 Switch II region; other site 701177008452 G4 box; other site 701177008453 G5 box; other site 701177008454 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 701177008455 putative hexamer interface [polypeptide binding]; other site 701177008456 putative hexagonal pore; other site 701177008457 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 701177008458 Malic enzyme, N-terminal domain; Region: malic; pfam00390 701177008459 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 701177008460 putative NAD(P) binding site [chemical binding]; other site 701177008461 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 701177008462 transaldolase-like protein; Provisional; Region: PTZ00411 701177008463 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 701177008464 active site 701177008465 dimer interface [polypeptide binding]; other site 701177008466 catalytic residue [active] 701177008467 transketolase; Reviewed; Region: PRK12753 701177008468 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 701177008469 TPP-binding site [chemical binding]; other site 701177008470 dimer interface [polypeptide binding]; other site 701177008471 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 701177008472 PYR/PP interface [polypeptide binding]; other site 701177008473 dimer interface [polypeptide binding]; other site 701177008474 TPP binding site [chemical binding]; other site 701177008475 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 701177008476 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 701177008477 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 701177008478 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 701177008479 dimer interface [polypeptide binding]; other site 701177008480 ADP-ribose binding site [chemical binding]; other site 701177008481 active site 701177008482 nudix motif; other site 701177008483 metal binding site [ion binding]; metal-binding site 701177008484 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 701177008485 4Fe-4S binding domain; Region: Fer4; pfam00037 701177008486 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 701177008487 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 701177008488 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 701177008489 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 701177008490 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 701177008491 dimerization interface [polypeptide binding]; other site 701177008492 Histidine kinase; Region: HisKA_3; pfam07730 701177008493 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 701177008494 ATP binding site [chemical binding]; other site 701177008495 Mg2+ binding site [ion binding]; other site 701177008496 G-X-G motif; other site 701177008497 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 701177008498 Protein export membrane protein; Region: SecD_SecF; cl14618 701177008499 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 701177008500 ArsC family; Region: ArsC; pfam03960 701177008501 putative catalytic residues [active] 701177008502 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 701177008503 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 701177008504 metal binding site [ion binding]; metal-binding site 701177008505 dimer interface [polypeptide binding]; other site 701177008506 hypothetical protein; Provisional; Region: PRK13664 701177008507 putative hydrolase; Provisional; Region: PRK11460 701177008508 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 701177008509 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 701177008510 Helicase; Region: Helicase_RecD; pfam05127 701177008511 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 701177008512 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 701177008513 Predicted metalloprotease [General function prediction only]; Region: COG2321 701177008514 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 701177008515 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 701177008516 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 701177008517 ATP binding site [chemical binding]; other site 701177008518 active site 701177008519 substrate binding site [chemical binding]; other site 701177008520 lipoprotein; Provisional; Region: PRK11679 701177008521 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 701177008522 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 701177008523 dihydrodipicolinate synthase; Region: dapA; TIGR00674 701177008524 dimer interface [polypeptide binding]; other site 701177008525 active site 701177008526 catalytic residue [active] 701177008527 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 701177008528 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 701177008529 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 701177008530 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 701177008531 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 701177008532 catalytic triad [active] 701177008533 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 701177008534 4Fe-4S binding domain; Region: Fer4; pfam00037 701177008535 hydrogenase 4 subunit B; Validated; Region: PRK06521 701177008536 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 701177008537 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 701177008538 NADH dehydrogenase; Region: NADHdh; cl00469 701177008539 hydrogenase 4 subunit D; Validated; Region: PRK06525 701177008540 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 701177008541 hydrogenase 4 membrane subunit; Provisional; Region: hyfE; PRK11492 701177008542 hydrogenase 4 subunit F; Validated; Region: PRK06458 701177008543 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 701177008544 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 701177008545 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 701177008546 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 701177008547 hydrogenase 4 subunit H; Validated; Region: PRK08222 701177008548 4Fe-4S binding domain; Region: Fer4; pfam00037 701177008549 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 701177008550 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 701177008551 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 701177008552 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 701177008553 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 701177008554 Walker A motif; other site 701177008555 ATP binding site [chemical binding]; other site 701177008556 Walker B motif; other site 701177008557 arginine finger; other site 701177008558 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 701177008559 putative formate transporter; Provisional; Region: focB; PRK09713 701177008560 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 701177008561 Domain of unknown function DUF20; Region: UPF0118; pfam01594 701177008562 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 701177008563 Peptidase family M48; Region: Peptidase_M48; cl12018 701177008564 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 701177008565 ArsC family; Region: ArsC; pfam03960 701177008566 catalytic residues [active] 701177008567 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 701177008568 DNA replication initiation factor; Provisional; Region: PRK08084 701177008569 uracil transporter; Provisional; Region: PRK10720 701177008570 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 701177008571 active site 701177008572 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 701177008573 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 701177008574 dimerization interface [polypeptide binding]; other site 701177008575 putative ATP binding site [chemical binding]; other site 701177008576 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 701177008577 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 701177008578 active site 701177008579 substrate binding site [chemical binding]; other site 701177008580 cosubstrate binding site; other site 701177008581 catalytic site [active] 701177008582 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 701177008583 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 701177008584 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 701177008585 Catalytic C-terminal domain, first repeat, of prokaryotic polyphosphate kinase 1 and similar proteins; Region: PLDc_PPK1_C1; cd09114 701177008586 domain interface [polypeptide binding]; other site 701177008587 active site 701177008588 catalytic site [active] 701177008589 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 701177008590 putative active site [active] 701177008591 catalytic site [active] 701177008592 exopolyphosphatase; Provisional; Region: PRK10854 701177008593 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 701177008594 MASE1; Region: MASE1; pfam05231 701177008595 diguanylate cyclase; Region: GGDEF; smart00267 701177008596 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 701177008597 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 701177008598 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 701177008599 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 701177008600 GMP synthase; Reviewed; Region: guaA; PRK00074 701177008601 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 701177008602 AMP/PPi binding site [chemical binding]; other site 701177008603 candidate oxyanion hole; other site 701177008604 catalytic triad [active] 701177008605 potential glutamine specificity residues [chemical binding]; other site 701177008606 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 701177008607 ATP Binding subdomain [chemical binding]; other site 701177008608 Ligand Binding sites [chemical binding]; other site 701177008609 Dimerization subdomain; other site 701177008610 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 701177008611 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 701177008612 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 701177008613 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 701177008614 active site 701177008615 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 701177008616 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 701177008617 generic binding surface II; other site 701177008618 generic binding surface I; other site 701177008619 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 701177008620 GTP-binding protein Der; Reviewed; Region: PRK00093 701177008621 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 701177008622 G1 box; other site 701177008623 GTP/Mg2+ binding site [chemical binding]; other site 701177008624 Switch I region; other site 701177008625 G2 box; other site 701177008626 Switch II region; other site 701177008627 G3 box; other site 701177008628 G4 box; other site 701177008629 G5 box; other site 701177008630 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 701177008631 G1 box; other site 701177008632 GTP/Mg2+ binding site [chemical binding]; other site 701177008633 Switch I region; other site 701177008634 G2 box; other site 701177008635 G3 box; other site 701177008636 Switch II region; other site 701177008637 G4 box; other site 701177008638 G5 box; other site 701177008639 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 701177008640 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cd00216 701177008641 Trp docking motif [polypeptide binding]; other site 701177008642 active site 701177008643 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 701177008644 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 701177008645 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 701177008646 dimer interface [polypeptide binding]; other site 701177008647 motif 1; other site 701177008648 active site 701177008649 motif 2; other site 701177008650 motif 3; other site 701177008651 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 701177008652 anticodon binding site; other site 701177008653 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 701177008654 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 701177008655 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 701177008656 cytoskeletal protein RodZ; Provisional; Region: PRK10856 701177008657 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 701177008658 non-specific DNA binding site [nucleotide binding]; other site 701177008659 salt bridge; other site 701177008660 sequence-specific DNA binding site [nucleotide binding]; other site 701177008661 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 701177008662 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 701177008663 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 701177008664 FeS/SAM binding site; other site 701177008665 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 701177008666 active site 701177008667 multimer interface [polypeptide binding]; other site 701177008668 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 701177008669 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 701177008670 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 701177008671 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 701177008672 4Fe-4S binding domain; Region: Fer4; pfam00037 701177008673 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 701177008674 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 701177008675 putative [Fe4-S4] binding site [ion binding]; other site 701177008676 putative molybdopterin cofactor binding site [chemical binding]; other site 701177008677 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 701177008678 putative molybdopterin cofactor binding site; other site 701177008679 penicillin-binding protein 1C; Provisional; Region: PRK11240 701177008680 Transglycosylase; Region: Transgly; pfam00912 701177008681 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 701177008682 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 701177008683 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 701177008684 MG2 domain; Region: A2M_N; pfam01835 701177008685 Alpha-2-macroglobulin family; Region: A2M; pfam00207 701177008686 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 701177008687 surface patch; other site 701177008688 thioester region; other site 701177008689 specificity defining residues; other site 701177008690 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 701177008691 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 701177008692 active site residue [active] 701177008693 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 701177008694 active site residue [active] 701177008695 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 701177008696 aminopeptidase B; Provisional; Region: PRK05015 701177008697 Peptidase; Region: DUF3663; pfam12404 701177008698 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 701177008699 interface (dimer of trimers) [polypeptide binding]; other site 701177008700 Substrate-binding/catalytic site; other site 701177008701 Zn-binding sites [ion binding]; other site 701177008702 hypothetical protein; Provisional; Region: PRK10721 701177008703 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 701177008704 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 701177008705 catalytic loop [active] 701177008706 iron binding site [ion binding]; other site 701177008707 chaperone protein HscA; Provisional; Region: hscA; PRK05183 701177008708 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 701177008709 nucleotide binding site [chemical binding]; other site 701177008710 putative NEF/HSP70 interaction site [polypeptide binding]; other site 701177008711 SBD interface [polypeptide binding]; other site 701177008712 co-chaperone HscB; Provisional; Region: hscB; PRK05014 701177008713 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 701177008714 HSP70 interaction site [polypeptide binding]; other site 701177008715 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 701177008716 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 701177008717 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 701177008718 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 701177008719 trimerization site [polypeptide binding]; other site 701177008720 active site 701177008721 cysteine desulfurase; Provisional; Region: PRK14012 701177008722 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 701177008723 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 701177008724 catalytic residue [active] 701177008725 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 701177008726 Rrf2 family protein; Region: rrf2_super; TIGR00738 701177008727 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 701177008728 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 701177008729 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 701177008730 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 701177008731 active site 701177008732 dimerization interface [polypeptide binding]; other site 701177008733 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 701177008734 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 701177008735 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 701177008736 PRD domain; Region: PRD; pfam00874 701177008737 PRD domain; Region: PRD; pfam00874 701177008738 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 701177008739 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177008740 putative substrate translocation pore; other site 701177008741 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 701177008742 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 701177008743 The C-terminal substrate binding domain of LysR-type transcriptional regulator HcaR in involved in 3-phenylpropionic acid catabolism, contains the type2 periplasmic binding fold; Region: PBP2_HcaR; cd08450 701177008744 putative dimerization interface [polypeptide binding]; other site 701177008745 putative substrate binding pocket [chemical binding]; other site 701177008746 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 701177008747 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 701177008748 iron-sulfur cluster [ion binding]; other site 701177008749 [2Fe-2S] cluster binding site [ion binding]; other site 701177008750 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 701177008751 beta subunit interface [polypeptide binding]; other site 701177008752 alpha subunit interface [polypeptide binding]; other site 701177008753 active site 701177008754 substrate binding site [chemical binding]; other site 701177008755 Fe binding site [ion binding]; other site 701177008756 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 701177008757 inter-subunit interface; other site 701177008758 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 701177008759 [2Fe-2S] cluster binding site [ion binding]; other site 701177008760 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 701177008761 cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase (BphB)-like, classical (c) SDRs; Region: BphB-like_SDR_c; cd05348 701177008762 NAD binding site [chemical binding]; other site 701177008763 active site 701177008764 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 701177008765 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 701177008766 Predicted membrane protein [Function unknown]; Region: COG2259 701177008767 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 701177008768 active site 701177008769 catalytic residues [active] 701177008770 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 701177008771 L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239 701177008772 putative NAD(P) binding site [chemical binding]; other site 701177008773 catalytic Zn binding site [ion binding]; other site 701177008774 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 701177008775 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 701177008776 TM-ABC transporter signature motif; other site 701177008777 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 701177008778 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 701177008779 Walker A/P-loop; other site 701177008780 ATP binding site [chemical binding]; other site 701177008781 Q-loop/lid; other site 701177008782 ABC transporter signature motif; other site 701177008783 Walker B; other site 701177008784 D-loop; other site 701177008785 H-loop/switch region; other site 701177008786 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 701177008787 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 701177008788 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 701177008789 ligand binding site [chemical binding]; other site 701177008790 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 701177008791 TPR motif; other site 701177008792 Tetratricopeptide repeat; Region: TPR_16; pfam13432 701177008793 binding surface 701177008794 TPR repeat; Region: TPR_11; pfam13414 701177008795 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 701177008796 TPR motif; other site 701177008797 binding surface 701177008798 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 701177008799 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 701177008800 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 701177008801 nucleotide binding site [chemical binding]; other site 701177008802 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 701177008803 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 701177008804 dimer interface [polypeptide binding]; other site 701177008805 active site 701177008806 glycine-pyridoxal phosphate binding site [chemical binding]; other site 701177008807 folate binding site [chemical binding]; other site 701177008808 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 701177008809 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 701177008810 heme-binding site [chemical binding]; other site 701177008811 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 701177008812 FAD binding pocket [chemical binding]; other site 701177008813 FAD binding motif [chemical binding]; other site 701177008814 phosphate binding motif [ion binding]; other site 701177008815 beta-alpha-beta structure motif; other site 701177008816 NAD binding pocket [chemical binding]; other site 701177008817 Heme binding pocket [chemical binding]; other site 701177008818 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 701177008819 Nitrogen regulatory protein P-II; Region: P-II; smart00938 701177008820 response regulator GlrR; Provisional; Region: PRK15115 701177008821 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 701177008822 active site 701177008823 phosphorylation site [posttranslational modification] 701177008824 intermolecular recognition site; other site 701177008825 dimerization interface [polypeptide binding]; other site 701177008826 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 701177008827 Walker A motif; other site 701177008828 ATP binding site [chemical binding]; other site 701177008829 Walker B motif; other site 701177008830 arginine finger; other site 701177008831 hypothetical protein; Provisional; Region: PRK10722 701177008832 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 701177008833 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 701177008834 dimer interface [polypeptide binding]; other site 701177008835 phosphorylation site [posttranslational modification] 701177008836 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 701177008837 ATP binding site [chemical binding]; other site 701177008838 Mg2+ binding site [ion binding]; other site 701177008839 G-X-G motif; other site 701177008840 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 701177008841 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 701177008842 dimerization interface [polypeptide binding]; other site 701177008843 ATP binding site [chemical binding]; other site 701177008844 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 701177008845 dimerization interface [polypeptide binding]; other site 701177008846 ATP binding site [chemical binding]; other site 701177008847 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 701177008848 putative active site [active] 701177008849 catalytic triad [active] 701177008850 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 701177008851 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 701177008852 substrate binding pocket [chemical binding]; other site 701177008853 membrane-bound complex binding site; other site 701177008854 hinge residues; other site 701177008855 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 701177008856 N-acetyl-D-glucosamine binding site [chemical binding]; other site 701177008857 catalytic residue [active] 701177008858 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 701177008859 nucleoside/Zn binding site; other site 701177008860 dimer interface [polypeptide binding]; other site 701177008861 catalytic motif [active] 701177008862 hypothetical protein; Provisional; Region: PRK11590 701177008863 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 701177008864 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 701177008865 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 701177008866 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 701177008867 putative active site [active] 701177008868 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 701177008869 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 701177008870 catalytic residues [active] 701177008871 catalytic nucleophile [active] 701177008872 Presynaptic Site I dimer interface [polypeptide binding]; other site 701177008873 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 701177008874 Synaptic Flat tetramer interface [polypeptide binding]; other site 701177008875 Synaptic Site I dimer interface [polypeptide binding]; other site 701177008876 DNA binding site [nucleotide binding] 701177008877 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 701177008878 DNA-binding interface [nucleotide binding]; DNA binding site 701177008879 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 701177008880 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 701177008881 Phage Tail Collar Domain; Region: Collar; pfam07484 701177008882 Protein of unknown function (DUF2612); Region: DUF2612; pfam11041 701177008883 Baseplate J-like protein; Region: Baseplate_J; cl01294 701177008884 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 701177008885 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 701177008886 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 701177008887 virion protein; Provisional; Region: V; PHA02564 701177008888 Protein of unknown function (DUF3277); Region: DUF3277; pfam11681 701177008889 Protein of unknown function (DUF3383); Region: DUF3383; pfam11863 701177008890 Superfamily II helicase, archaea-specific [General function prediction only]; Region: COG1202 701177008891 Protein of unknown function (DUF4054); Region: DUF4054; pfam13262 701177008892 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4834 701177008893 Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950 701177008894 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979 701177008895 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 701177008896 phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555 701177008897 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 701177008898 Terminase small subunit; Region: Terminase_2; pfam03592 701177008899 The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes. But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736 701177008900 N-acetyl-D-glucosamine binding site [chemical binding]; other site 701177008901 catalytic residue [active] 701177008902 Phage holin family (Lysis protein S); Region: Phage_holin_3; cl04938 701177008903 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 701177008904 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 701177008905 polymerase nucleotide-binding site; other site 701177008906 DNA-binding residues [nucleotide binding]; DNA binding site 701177008907 nucleotide binding site [chemical binding]; other site 701177008908 primase nucleotide-binding site [nucleotide binding]; other site 701177008909 Virulence-associated protein E; Region: VirE; pfam05272 701177008910 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 701177008911 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 701177008912 non-specific DNA binding site [nucleotide binding]; other site 701177008913 salt bridge; other site 701177008914 sequence-specific DNA binding site [nucleotide binding]; other site 701177008915 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 701177008916 Catalytic site [active] 701177008917 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 701177008918 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 701177008919 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 701177008920 active site 701177008921 substrate binding site [chemical binding]; other site 701177008922 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 701177008923 active site 701177008924 DNA binding site [nucleotide binding] 701177008925 catalytic site [active] 701177008926 YfbU domain; Region: YfbU; cl01137 701177008927 VRR-NUC domain; Region: VRR_NUC; pfam08774 701177008928 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 701177008929 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 701177008930 nucleotide binding region [chemical binding]; other site 701177008931 ATP-binding site [chemical binding]; other site 701177008932 Helix-turn-helix domain; Region: HTH_17; pfam12728 701177008933 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 701177008934 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 701177008935 holo-[acyl-carrier-protein] synthase; Region: acpS; TIGR00516 701177008936 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 701177008937 active site 701177008938 hydrophilic channel; other site 701177008939 dimerization interface [polypeptide binding]; other site 701177008940 catalytic residues [active] 701177008941 active site lid [active] 701177008942 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 701177008943 Recombination protein O N terminal; Region: RecO_N; pfam11967 701177008944 Recombination protein O C terminal; Region: RecO_C; pfam02565 701177008945 GTPase Era; Reviewed; Region: era; PRK00089 701177008946 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 701177008947 G1 box; other site 701177008948 GTP/Mg2+ binding site [chemical binding]; other site 701177008949 Switch I region; other site 701177008950 G2 box; other site 701177008951 Switch II region; other site 701177008952 G3 box; other site 701177008953 G4 box; other site 701177008954 G5 box; other site 701177008955 KH domain; Region: KH_2; pfam07650 701177008956 ribonuclease III; Reviewed; Region: rnc; PRK00102 701177008957 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 701177008958 dimerization interface [polypeptide binding]; other site 701177008959 active site 701177008960 metal binding site [ion binding]; metal-binding site 701177008961 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 701177008962 dsRNA binding site [nucleotide binding]; other site 701177008963 signal peptidase I; Provisional; Region: PRK10861 701177008964 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 701177008965 Catalytic site [active] 701177008966 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 701177008967 GTP-binding protein LepA; Provisional; Region: PRK05433 701177008968 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 701177008969 G1 box; other site 701177008970 putative GEF interaction site [polypeptide binding]; other site 701177008971 GTP/Mg2+ binding site [chemical binding]; other site 701177008972 Switch I region; other site 701177008973 G2 box; other site 701177008974 G3 box; other site 701177008975 Switch II region; other site 701177008976 G4 box; other site 701177008977 G5 box; other site 701177008978 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 701177008979 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 701177008980 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 701177008981 SoxR reducing system protein RseC; Provisional; Region: PRK10862 701177008982 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 701177008983 anti-sigma E factor; Provisional; Region: rseB; PRK09455 701177008984 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 701177008985 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 701177008986 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 701177008987 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 701177008988 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 701177008989 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 701177008990 DNA binding residues [nucleotide binding] 701177008991 L-aspartate oxidase; Provisional; Region: PRK09077 701177008992 L-aspartate oxidase; Provisional; Region: PRK06175 701177008993 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 701177008994 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 701177008995 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 701177008996 S-adenosylmethionine binding site [chemical binding]; other site 701177008997 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 701177008998 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 701177008999 ATP binding site [chemical binding]; other site 701177009000 Mg++ binding site [ion binding]; other site 701177009001 motif III; other site 701177009002 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 701177009003 nucleotide binding region [chemical binding]; other site 701177009004 ATP-binding site [chemical binding]; other site 701177009005 Transcriptional regulator [Transcription]; Region: LysR; COG0583 701177009006 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 701177009007 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 701177009008 dimerization interface [polypeptide binding]; other site 701177009009 cysteine/O-acetylserine exporter; Provisional; Region: PRK10323 701177009010 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 701177009011 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 701177009012 ligand binding site [chemical binding]; other site 701177009013 active site 701177009014 UGI interface [polypeptide binding]; other site 701177009015 catalytic site [active] 701177009016 putative methyltransferase; Provisional; Region: PRK10864 701177009017 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 701177009018 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 701177009019 thioredoxin 2; Provisional; Region: PRK10996 701177009020 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 701177009021 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 701177009022 catalytic residues [active] 701177009023 Uncharacterized conserved protein [Function unknown]; Region: COG3148 701177009024 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 701177009025 CoA binding domain; Region: CoA_binding_2; pfam13380 701177009026 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 701177009027 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 701177009028 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 701177009029 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 701177009030 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 701177009031 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 701177009032 domain interface [polypeptide binding]; other site 701177009033 putative active site [active] 701177009034 catalytic site [active] 701177009035 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 701177009036 domain interface [polypeptide binding]; other site 701177009037 putative active site [active] 701177009038 catalytic site [active] 701177009039 lipoprotein; Provisional; Region: PRK10759 701177009040 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 701177009041 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177009042 putative substrate translocation pore; other site 701177009043 protein disaggregation chaperone; Provisional; Region: PRK10865 701177009044 Clp amino terminal domain; Region: Clp_N; pfam02861 701177009045 Clp amino terminal domain; Region: Clp_N; pfam02861 701177009046 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 701177009047 Walker A motif; other site 701177009048 ATP binding site [chemical binding]; other site 701177009049 Walker B motif; other site 701177009050 arginine finger; other site 701177009051 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 701177009052 Walker A motif; other site 701177009053 ATP binding site [chemical binding]; other site 701177009054 Walker B motif; other site 701177009055 arginine finger; other site 701177009056 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 701177009057 hypothetical protein; Provisional; Region: PRK10723 701177009058 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 701177009059 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 701177009060 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 701177009061 RNA binding surface [nucleotide binding]; other site 701177009062 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 701177009063 active site 701177009064 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 701177009065 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 701177009066 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 701177009067 30S subunit binding site; other site 701177009068 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 701177009069 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 701177009070 Prephenate dehydratase; Region: PDT; pfam00800 701177009071 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 701177009072 putative L-Phe binding site [chemical binding]; other site 701177009073 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 701177009074 Chorismate mutase type II; Region: CM_2; cl00693 701177009075 prephenate dehydrogenase; Validated; Region: PRK08507 701177009076 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 701177009077 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 701177009078 lipoprotein; Provisional; Region: PRK11443 701177009079 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 701177009080 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 701177009081 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 701177009082 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 701177009083 metal binding site [ion binding]; metal-binding site 701177009084 active site 701177009085 I-site; other site 701177009086 putative outer membrane lipoprotein; Provisional; Region: PRK09967 701177009087 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 701177009088 ligand binding site [chemical binding]; other site 701177009089 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 701177009090 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 701177009091 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 701177009092 RimM N-terminal domain; Region: RimM; pfam01782 701177009093 PRC-barrel domain; Region: PRC; pfam05239 701177009094 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 701177009095 signal recognition particle protein; Provisional; Region: PRK10867 701177009096 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 701177009097 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 701177009098 P loop; other site 701177009099 GTP binding site [chemical binding]; other site 701177009100 Signal peptide binding domain; Region: SRP_SPB; pfam02978 701177009101 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 701177009102 hypothetical protein; Provisional; Region: PRK11573 701177009103 Domain of unknown function DUF21; Region: DUF21; pfam01595 701177009104 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 701177009105 Transporter associated domain; Region: CorC_HlyC; smart01091 701177009106 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 701177009107 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 701177009108 dimer interface [polypeptide binding]; other site 701177009109 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 701177009110 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 701177009111 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 701177009112 recombination and repair protein; Provisional; Region: PRK10869 701177009113 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 701177009114 Walker A/P-loop; other site 701177009115 ATP binding site [chemical binding]; other site 701177009116 Q-loop/lid; other site 701177009117 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 701177009118 Q-loop/lid; other site 701177009119 ABC transporter signature motif; other site 701177009120 Walker B; other site 701177009121 D-loop; other site 701177009122 H-loop/switch region; other site 701177009123 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 701177009124 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 701177009125 hypothetical protein; Validated; Region: PRK01777 701177009126 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 701177009127 putative coenzyme Q binding site [chemical binding]; other site 701177009128 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 701177009129 SmpB-tmRNA interface; other site 701177009130 DinI-like family; Region: DinI; pfam06183 701177009131 IpaB/EvcA family; Region: IpaB_EvcA; pfam03278 701177009132 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 701177009133 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 701177009134 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 701177009135 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 701177009136 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 701177009137 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 701177009138 Phage-related protein, tail component [Function unknown]; Region: COG4733 701177009139 Putative phage tail protein; Region: Phage-tail_3; pfam13550 701177009140 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 701177009141 Interdomain contacts; other site 701177009142 Cytokine receptor motif; other site 701177009143 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 701177009144 Fibronectin type III protein; Region: DUF3672; pfam12421 701177009145 Phage-related protein, tail component [Function unknown]; Region: COG4723 701177009146 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 701177009147 MPN+ (JAMM) motif; other site 701177009148 Zinc-binding site [ion binding]; other site 701177009149 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 701177009150 NlpC/P60 family; Region: NLPC_P60; cl17555 701177009151 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 701177009152 Phage anti-repressor protein [Transcription]; Region: COG3561 701177009153 Phage-related protein [Function unknown]; Region: gp18; COG4672 701177009154 Phage-related protein [Function unknown]; Region: COG4718 701177009155 Phage-related minor tail protein [Function unknown]; Region: COG5281 701177009156 tape measure domain; Region: tape_meas_nterm; TIGR02675 701177009157 Tail length tape measure protein; Region: Phage_HK97_TLTM; pfam06120 701177009158 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 701177009159 Protein of unknown function (DUF4035); Region: DUF4035; pfam13227 701177009160 Phage tail assembly chaperone; Region: Phage_TAC; pfam06222 701177009161 Immunoglobulin domain; Region: Ig_3; pfam13927 701177009162 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 701177009163 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 701177009164 Bacteriophage head-tail adaptor [General function prediction only]; Region: COG5614 701177009165 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 701177009166 zinc binding site [ion binding]; other site 701177009167 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 701177009168 Phage-related protein [Function unknown]; Region: COG4695 701177009169 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 701177009170 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 701177009171 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 701177009172 Phage capsid family; Region: Phage_capsid; pfam05065 701177009173 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 701177009174 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 701177009175 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 701177009176 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 701177009177 active site 701177009178 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 701177009179 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 701177009180 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 701177009181 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 701177009182 ORF11CD3 domain; Region: ORF11CD3; pfam10549 701177009183 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 701177009184 catalytic residues [active] 701177009185 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 701177009186 Lysis protein S; Region: Lysis_S; pfam04971 701177009187 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 701177009188 Transposase; Region: HTH_Tnp_1; cl17663 701177009189 Integrase core domain; Region: rve; pfam00665 701177009190 DDE domain; Region: DDE_Tnp_IS240; pfam13610 701177009191 Integrase core domain; Region: rve_3; pfam13683 701177009192 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 701177009193 Domain of unknown function (DUF303); Region: DUF303; pfam03629 701177009194 tellurium resistance terB-like protein; Region: terB_like; cl11965 701177009195 tellurite resistance protein terB; Region: terB; cd07176 701177009196 putative metal binding site [ion binding]; other site 701177009197 DNA methylase; Region: N6_N4_Mtase; cl17433 701177009198 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 701177009199 Phage NinH protein; Region: Phage_NinH; pfam06322 701177009200 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 701177009201 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 701177009202 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 701177009203 ORF6N domain; Region: ORF6N; pfam10543 701177009204 Phage anti-repressor protein [Transcription]; Region: COG3561 701177009205 NINE Protein; Region: NinE; pfam05322 701177009206 phage N-6-adenine-methyltransferase; Region: phage_N6A_met; TIGR01712 701177009207 NinB protein; Region: NinB; pfam05772 701177009208 Replication protein P; Region: Phage_lambda_P; pfam06992 701177009209 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 701177009210 Bacteriophage CII protein; Region: Phage_CII; pfam05269 701177009211 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 701177009212 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 701177009213 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 701177009214 non-specific DNA binding site [nucleotide binding]; other site 701177009215 salt bridge; other site 701177009216 sequence-specific DNA binding site [nucleotide binding]; other site 701177009217 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 701177009218 Catalytic site [active] 701177009219 Protein of unknown function (DUF2528); Region: DUF2528; pfam10800 701177009220 Lambda Phage CIII; Region: Lambda_CIII; pfam02061 701177009221 Bacteriophage lambda Kil protein; Region: Lambda_Kil; pfam06301 701177009222 phage recombination protein Bet; Region: bet_lambda; TIGR01913 701177009223 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 701177009224 Protein of unknown function (DUF1317); Region: DUF1317; pfam07026 701177009225 Protein of unknown function (DUF1382); Region: DUF1382; pfam07131 701177009226 DksA-like zinc finger domain containing protein; Region: PHA00080 701177009227 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 701177009228 Protein of unknown function (DUF551); Region: DUF551; pfam04448 701177009229 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 701177009230 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 701177009231 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 701177009232 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 701177009233 Int/Topo IB signature motif; other site 701177009234 integrase; Provisional; Region: PRK09692 701177009235 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 701177009236 active site 701177009237 Int/Topo IB signature motif; other site 701177009238 sporadically distributed protein, TIGR04141 family; Region: TIGR04141 701177009239 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 701177009240 His-Xaa-Ser system radical SAM maturase HxsC; Region: rSAM_pair_HxsC; TIGR03977 701177009241 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 701177009242 FeS/SAM binding site; other site 701177009243 His-Xaa-Ser system radical SAM maturase HxsB; Region: rSAM_paired_1; TIGR03978 701177009244 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 701177009245 FeS/SAM binding site; other site 701177009246 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 701177009247 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 701177009248 AAA domain; Region: AAA_23; pfam13476 701177009249 Walker A/P-loop; other site 701177009250 ATP binding site [chemical binding]; other site 701177009251 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 701177009252 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 701177009253 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4688 701177009254 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 701177009255 active site 701177009256 catalytic residues [active] 701177009257 DNA binding site [nucleotide binding] 701177009258 Int/Topo IB signature motif; other site 701177009259 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 701177009260 active site 701177009261 catalytic residues [active] 701177009262 DNA binding site [nucleotide binding] 701177009263 Int/Topo IB signature motif; other site 701177009264 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 701177009265 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac1_AmyA; cd11315 701177009266 active site 701177009267 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 701177009268 Ca binding site [ion binding]; other site 701177009269 catalytic site [active] 701177009270 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 701177009271 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 701177009272 substrate binding pocket [chemical binding]; other site 701177009273 active site 701177009274 iron coordination sites [ion binding]; other site 701177009275 Predicted dehydrogenase [General function prediction only]; Region: COG0579 701177009276 hydroxyglutarate oxidase; Provisional; Region: PRK11728 701177009277 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 701177009278 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 701177009279 tetramerization interface [polypeptide binding]; other site 701177009280 NAD(P) binding site [chemical binding]; other site 701177009281 catalytic residues [active] 701177009282 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 701177009283 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 701177009284 inhibitor-cofactor binding pocket; inhibition site 701177009285 pyridoxal 5'-phosphate binding site [chemical binding]; other site 701177009286 catalytic residue [active] 701177009287 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 701177009288 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 701177009289 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 701177009290 DNA-binding site [nucleotide binding]; DNA binding site 701177009291 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 701177009292 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 701177009293 bacterial OsmY and nodulation domain; Region: BON; smart00749 701177009294 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 701177009295 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 701177009296 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 701177009297 dimerization interface [polypeptide binding]; other site 701177009298 putative DNA binding site [nucleotide binding]; other site 701177009299 Transcriptional regulators [Transcription]; Region: MarR; COG1846 701177009300 putative Zn2+ binding site [ion binding]; other site 701177009301 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YgaP, and similar uncharacterized putative rhodanese-related sulfurtransferases; Region: RHOD_YgaP; cd01527 701177009302 active site residue [active] 701177009303 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 701177009304 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 701177009305 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 701177009306 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 701177009307 hypothetical protein; Provisional; Region: PRK10556 701177009308 hypothetical protein; Provisional; Region: PRK10132 701177009309 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 701177009310 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 701177009311 DNA-binding site [nucleotide binding]; DNA binding site 701177009312 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 701177009313 pyridoxal 5'-phosphate binding site [chemical binding]; other site 701177009314 homodimer interface [polypeptide binding]; other site 701177009315 catalytic residue [active] 701177009316 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 701177009317 Uncharacterized conserved protein [Function unknown]; Region: COG2128 701177009318 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 701177009319 catalytic residues [active] 701177009320 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 701177009321 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 701177009322 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 701177009323 Class I ribonucleotide reductase; Region: RNR_I; cd01679 701177009324 active site 701177009325 dimer interface [polypeptide binding]; other site 701177009326 catalytic residues [active] 701177009327 effector binding site; other site 701177009328 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 701177009329 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 701177009330 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 701177009331 dimer interface [polypeptide binding]; other site 701177009332 putative radical transfer pathway; other site 701177009333 diiron center [ion binding]; other site 701177009334 tyrosyl radical; other site 701177009335 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 701177009336 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 701177009337 Walker A/P-loop; other site 701177009338 ATP binding site [chemical binding]; other site 701177009339 Q-loop/lid; other site 701177009340 ABC transporter signature motif; other site 701177009341 Walker B; other site 701177009342 D-loop; other site 701177009343 H-loop/switch region; other site 701177009344 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 701177009345 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 701177009346 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 701177009347 dimer interface [polypeptide binding]; other site 701177009348 conserved gate region; other site 701177009349 putative PBP binding loops; other site 701177009350 ABC-ATPase subunit interface; other site 701177009351 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 701177009352 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 701177009353 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 701177009354 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177009355 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 701177009356 putative L-valine exporter; Provisional; Region: PRK10408 701177009357 transcriptional repressor MprA; Provisional; Region: PRK10870 701177009358 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 701177009359 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 701177009360 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 701177009361 HlyD family secretion protein; Region: HlyD_3; pfam13437 701177009362 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 701177009363 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177009364 putative substrate translocation pore; other site 701177009365 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177009366 S-ribosylhomocysteinase; Provisional; Region: PRK02260 701177009367 glutamate--cysteine ligase; Provisional; Region: PRK02107 701177009368 Predicted membrane protein [Function unknown]; Region: COG1238 701177009369 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 701177009370 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 701177009371 motif II; other site 701177009372 carbon storage regulator; Provisional; Region: PRK01712 701177009373 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 701177009374 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 701177009375 motif 1; other site 701177009376 active site 701177009377 motif 2; other site 701177009378 motif 3; other site 701177009379 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 701177009380 DHHA1 domain; Region: DHHA1; pfam02272 701177009381 recombination regulator RecX; Reviewed; Region: recX; PRK00117 701177009382 recombinase A; Provisional; Region: recA; PRK09354 701177009383 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 701177009384 hexamer interface [polypeptide binding]; other site 701177009385 Walker A motif; other site 701177009386 ATP binding site [chemical binding]; other site 701177009387 Walker B motif; other site 701177009388 hypothetical protein; Validated; Region: PRK03661 701177009389 Transglycosylase SLT domain; Region: SLT_2; pfam13406 701177009390 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 701177009391 N-acetyl-D-glucosamine binding site [chemical binding]; other site 701177009392 PTS system, glucitol/sorbitol-specific, IIC component; Region: EII-GUT; TIGR00821 701177009393 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 701177009394 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 701177009395 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 701177009396 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 701177009397 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 701177009398 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 701177009399 putative NAD(P) binding site [chemical binding]; other site 701177009400 active site 701177009401 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 701177009402 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 701177009403 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 701177009404 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 701177009405 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 701177009406 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 701177009407 putative active site [active] 701177009408 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 701177009409 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 701177009410 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 701177009411 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 701177009412 Walker A motif; other site 701177009413 ATP binding site [chemical binding]; other site 701177009414 Walker B motif; other site 701177009415 arginine finger; other site 701177009416 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 701177009417 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 701177009418 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 701177009419 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 701177009420 iron binding site [ion binding]; other site 701177009421 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 701177009422 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 701177009423 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 701177009424 Acylphosphatase; Region: Acylphosphatase; pfam00708 701177009425 HypF finger; Region: zf-HYPF; pfam07503 701177009426 HypF finger; Region: zf-HYPF; pfam07503 701177009427 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 701177009428 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 701177009429 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 701177009430 Transcriptional regulators [Transcription]; Region: PurR; COG1609 701177009431 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 701177009432 DNA binding site [nucleotide binding] 701177009433 domain linker motif; other site 701177009434 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 701177009435 dimerization interface (closed form) [polypeptide binding]; other site 701177009436 ligand binding site [chemical binding]; other site 701177009437 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 701177009438 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 701177009439 active site turn [active] 701177009440 phosphorylation site [posttranslational modification] 701177009441 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 701177009442 cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852 701177009443 beta-galactosidase; Region: BGL; TIGR03356 701177009444 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 701177009445 nickel binding site [ion binding]; other site 701177009446 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 701177009447 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 701177009448 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 701177009449 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 701177009450 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 701177009451 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 701177009452 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 701177009453 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 701177009454 NADH dehydrogenase; Region: NADHdh; cl00469 701177009455 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 701177009456 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 701177009457 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 701177009458 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 701177009459 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 701177009460 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 701177009461 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 701177009462 hydrogenase assembly chaperone; Provisional; Region: PRK10409 701177009463 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 701177009464 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 701177009465 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 701177009466 dimerization interface [polypeptide binding]; other site 701177009467 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 701177009468 ATP binding site [chemical binding]; other site 701177009469 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 701177009470 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 701177009471 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 701177009472 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 701177009473 Walker A motif; other site 701177009474 ATP binding site [chemical binding]; other site 701177009475 Walker B motif; other site 701177009476 arginine finger; other site 701177009477 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 701177009478 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 701177009479 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 701177009480 MutS domain I; Region: MutS_I; pfam01624 701177009481 MutS domain II; Region: MutS_II; pfam05188 701177009482 MutS domain III; Region: MutS_III; pfam05192 701177009483 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 701177009484 Walker A/P-loop; other site 701177009485 ATP binding site [chemical binding]; other site 701177009486 Q-loop/lid; other site 701177009487 ABC transporter signature motif; other site 701177009488 Walker B; other site 701177009489 D-loop; other site 701177009490 H-loop/switch region; other site 701177009491 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 701177009492 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 701177009493 active site 701177009494 metal binding site [ion binding]; metal-binding site 701177009495 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 701177009496 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 701177009497 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 701177009498 Flavoprotein; Region: Flavoprotein; pfam02441 701177009499 MarR family; Region: MarR_2; cl17246 701177009500 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 701177009501 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 701177009502 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 701177009503 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 701177009504 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 701177009505 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 701177009506 DNA binding residues [nucleotide binding] 701177009507 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 701177009508 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 701177009509 Peptidase family M23; Region: Peptidase_M23; pfam01551 701177009510 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 701177009511 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 701177009512 S-adenosylmethionine binding site [chemical binding]; other site 701177009513 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 701177009514 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 701177009515 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 701177009516 Permutation of conserved domain; other site 701177009517 active site 701177009518 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 701177009519 homotrimer interaction site [polypeptide binding]; other site 701177009520 zinc binding site [ion binding]; other site 701177009521 CDP-binding sites; other site 701177009522 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 701177009523 substrate binding site; other site 701177009524 dimer interface; other site 701177009525 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 701177009526 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 701177009527 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 701177009528 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 701177009529 ligand-binding site [chemical binding]; other site 701177009530 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 701177009531 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 701177009532 CysD dimerization site [polypeptide binding]; other site 701177009533 G1 box; other site 701177009534 putative GEF interaction site [polypeptide binding]; other site 701177009535 GTP/Mg2+ binding site [chemical binding]; other site 701177009536 Switch I region; other site 701177009537 G2 box; other site 701177009538 G3 box; other site 701177009539 Switch II region; other site 701177009540 G4 box; other site 701177009541 G5 box; other site 701177009542 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 701177009543 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 701177009544 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 701177009545 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 701177009546 Active Sites [active] 701177009547 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 701177009548 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 701177009549 metal binding site [ion binding]; metal-binding site 701177009550 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648 701177009551 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 701177009552 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09664 701177009553 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 701177009554 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 701177009555 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cd09646 701177009556 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09670 701177009557 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09669 701177009558 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 701177009559 CRISPR-associated helicase Cas3 [Defense mechanisms]; Region: COG1203 701177009560 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 701177009561 Hok/gef family; Region: HOK_GEF; pfam01848 701177009562 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 701177009563 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 701177009564 Active Sites [active] 701177009565 sulfite reductase subunit beta; Provisional; Region: PRK13504 701177009566 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 701177009567 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 701177009568 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 701177009569 Flavodoxin; Region: Flavodoxin_1; pfam00258 701177009570 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 701177009571 FAD binding pocket [chemical binding]; other site 701177009572 FAD binding motif [chemical binding]; other site 701177009573 catalytic residues [active] 701177009574 NAD binding pocket [chemical binding]; other site 701177009575 phosphate binding motif [ion binding]; other site 701177009576 beta-alpha-beta structure motif; other site 701177009577 6-pyruvoyl tetrahydropterin synthase (PTPS). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids, as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after uptake by a...; Region: PTPS; cd00470 701177009578 homohexamer interface [polypeptide binding]; other site 701177009579 putative substrate stabilizing pore; other site 701177009580 pterin binding site; other site 701177009581 putative oxidoreductase FixC; Provisional; Region: PRK10157 701177009582 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 701177009583 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 701177009584 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 701177009585 Ligand binding site [chemical binding]; other site 701177009586 Electron transfer flavoprotein domain; Region: ETF; pfam01012 701177009587 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 701177009588 benzoate transport; Region: 2A0115; TIGR00895 701177009589 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177009590 putative substrate translocation pore; other site 701177009591 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 701177009592 FAD binding domain; Region: FAD_binding_4; pfam01565 701177009593 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 701177009594 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 701177009595 NADP binding site [chemical binding]; other site 701177009596 homodimer interface [polypeptide binding]; other site 701177009597 active site 701177009598 Major Facilitator Superfamily; Region: MFS_1; pfam07690 701177009599 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177009600 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 701177009601 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 701177009602 nucleotide binding site [chemical binding]; other site 701177009603 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 701177009604 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 701177009605 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 701177009606 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 701177009607 Repair protein; Region: Repair_PSII; pfam04536 701177009608 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 701177009609 Repair protein; Region: Repair_PSII; pfam04536 701177009610 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 701177009611 Repair protein; Region: Repair_PSII; pfam04536 701177009612 enolase; Provisional; Region: eno; PRK00077 701177009613 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 701177009614 dimer interface [polypeptide binding]; other site 701177009615 metal binding site [ion binding]; metal-binding site 701177009616 substrate binding pocket [chemical binding]; other site 701177009617 CTP synthetase; Validated; Region: pyrG; PRK05380 701177009618 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 701177009619 Catalytic site [active] 701177009620 active site 701177009621 UTP binding site [chemical binding]; other site 701177009622 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 701177009623 active site 701177009624 putative oxyanion hole; other site 701177009625 catalytic triad [active] 701177009626 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 701177009627 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 701177009628 homodimer interface [polypeptide binding]; other site 701177009629 metal binding site [ion binding]; metal-binding site 701177009630 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 701177009631 homodimer interface [polypeptide binding]; other site 701177009632 active site 701177009633 putative chemical substrate binding site [chemical binding]; other site 701177009634 metal binding site [ion binding]; metal-binding site 701177009635 toxin MazF; Provisional; Region: PRK09907 701177009636 antitoxin MazE; Provisional; Region: PRK09798 701177009637 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 701177009638 HD domain; Region: HD_4; pfam13328 701177009639 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 701177009640 synthetase active site [active] 701177009641 NTP binding site [chemical binding]; other site 701177009642 metal binding site [ion binding]; metal-binding site 701177009643 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 701177009644 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 701177009645 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 701177009646 TRAM domain; Region: TRAM; pfam01938 701177009647 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 701177009648 S-adenosylmethionine binding site [chemical binding]; other site 701177009649 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 701177009650 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 701177009651 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 701177009652 dimerization interface [polypeptide binding]; other site 701177009653 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 701177009654 dimer interface [polypeptide binding]; other site 701177009655 phosphorylation site [posttranslational modification] 701177009656 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 701177009657 ATP binding site [chemical binding]; other site 701177009658 Mg2+ binding site [ion binding]; other site 701177009659 G-X-G motif; other site 701177009660 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 701177009661 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 701177009662 active site 701177009663 phosphorylation site [posttranslational modification] 701177009664 intermolecular recognition site; other site 701177009665 dimerization interface [polypeptide binding]; other site 701177009666 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 701177009667 putative binding surface; other site 701177009668 active site 701177009669 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 701177009670 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 701177009671 active site 701177009672 tetramer interface [polypeptide binding]; other site 701177009673 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 701177009674 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 701177009675 active site 701177009676 tetramer interface [polypeptide binding]; other site 701177009677 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177009678 D-galactonate transporter; Region: 2A0114; TIGR00893 701177009679 putative substrate translocation pore; other site 701177009680 flavodoxin; Provisional; Region: PRK08105 701177009681 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 701177009682 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 701177009683 probable active site [active] 701177009684 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 701177009685 SecY interacting protein Syd; Provisional; Region: PRK04968 701177009686 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 701177009687 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 701177009688 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 701177009689 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 701177009690 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 701177009691 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 701177009692 serine transporter; Region: stp; TIGR00814 701177009693 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 701177009694 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 701177009695 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 701177009696 flap endonuclease-like protein; Provisional; Region: PRK09482 701177009697 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 701177009698 active site 701177009699 metal binding site 1 [ion binding]; metal-binding site 701177009700 putative 5' ssDNA interaction site; other site 701177009701 metal binding site 3; metal-binding site 701177009702 metal binding site 2 [ion binding]; metal-binding site 701177009703 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 701177009704 putative DNA binding site [nucleotide binding]; other site 701177009705 putative metal binding site [ion binding]; other site 701177009706 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 701177009707 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 701177009708 dimer interface [polypeptide binding]; other site 701177009709 active site 701177009710 metal binding site [ion binding]; metal-binding site 701177009711 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 701177009712 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 701177009713 intersubunit interface [polypeptide binding]; other site 701177009714 active site 701177009715 Zn2+ binding site [ion binding]; other site 701177009716 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 701177009717 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177009718 putative substrate translocation pore; other site 701177009719 L-fucose isomerase; Provisional; Region: fucI; PRK10991 701177009720 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 701177009721 hexamer (dimer of trimers) interface [polypeptide binding]; other site 701177009722 trimer interface [polypeptide binding]; other site 701177009723 substrate binding site [chemical binding]; other site 701177009724 Mn binding site [ion binding]; other site 701177009725 L-fuculokinase; Provisional; Region: PRK10331 701177009726 L-fuculose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_FK; cd07773 701177009727 putative N- and C-terminal domain interface [polypeptide binding]; other site 701177009728 putative active site [active] 701177009729 putative MgATP binding site [chemical binding]; other site 701177009730 putative catalytic site [active] 701177009731 metal binding site [ion binding]; metal-binding site 701177009732 putative carbohydrate binding site [chemical binding]; other site 701177009733 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 701177009734 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 701177009735 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 701177009736 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 701177009737 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 701177009738 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 701177009739 hypothetical protein; Provisional; Region: PRK10873 701177009740 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 701177009741 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 701177009742 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 701177009743 dimerization interface [polypeptide binding]; other site 701177009744 substrate binding pocket [chemical binding]; other site 701177009745 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 701177009746 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 701177009747 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 701177009748 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 701177009749 catalytic residue [active] 701177009750 CsdA-binding activator; Provisional; Region: PRK15019 701177009751 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 701177009752 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 701177009753 putative ATP binding site [chemical binding]; other site 701177009754 putative substrate interface [chemical binding]; other site 701177009755 murein transglycosylase A; Provisional; Region: mltA; PRK11162 701177009756 MltA specific insert domain; Region: MltA; pfam03562 701177009757 3D domain; Region: 3D; pfam06725 701177009758 AMIN domain; Region: AMIN; pfam11741 701177009759 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 701177009760 active site 701177009761 metal binding site [ion binding]; metal-binding site 701177009762 N-acetylglutamate synthase; Validated; Region: PRK05279 701177009763 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 701177009764 putative feedback inhibition sensing region; other site 701177009765 putative nucleotide binding site [chemical binding]; other site 701177009766 putative substrate binding site [chemical binding]; other site 701177009767 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 701177009768 Coenzyme A binding pocket [chemical binding]; other site 701177009769 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 701177009770 AAA domain; Region: AAA_30; pfam13604 701177009771 Family description; Region: UvrD_C_2; pfam13538 701177009772 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 701177009773 protease3; Provisional; Region: PRK15101 701177009774 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 701177009775 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 701177009776 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 701177009777 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 701177009778 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 701177009779 hypothetical protein; Provisional; Region: PRK10332 701177009780 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 701177009781 hypothetical protein; Provisional; Region: PRK11521 701177009782 hypothetical protein; Provisional; Region: PRK10557 701177009783 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 701177009784 hypothetical protein; Provisional; Region: PRK10506 701177009785 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 701177009786 thymidylate synthase; Reviewed; Region: thyA; PRK01827 701177009787 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 701177009788 dimerization interface [polypeptide binding]; other site 701177009789 active site 701177009790 prolipoprotein diacylglyceryl transferase; Region: lgt; TIGR00544 701177009791 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 701177009792 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 701177009793 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 701177009794 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 701177009795 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 701177009796 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 701177009797 putative active site [active] 701177009798 Ap4A binding site [chemical binding]; other site 701177009799 nudix motif; other site 701177009800 putative metal binding site [ion binding]; other site 701177009801 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 701177009802 putative DNA-binding cleft [nucleotide binding]; other site 701177009803 putative DNA clevage site; other site 701177009804 molecular lever; other site 701177009805 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 701177009806 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 701177009807 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 701177009808 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 701177009809 active site 701177009810 catalytic tetrad [active] 701177009811 lysophospholipid transporter LplT; Provisional; Region: PRK11195 701177009812 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177009813 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 701177009814 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 701177009815 putative acyl-acceptor binding pocket; other site 701177009816 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 701177009817 acyl-activating enzyme (AAE) consensus motif; other site 701177009818 putative AMP binding site [chemical binding]; other site 701177009819 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 701177009820 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 701177009821 DNA binding site [nucleotide binding] 701177009822 domain linker motif; other site 701177009823 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 701177009824 dimerization interface (closed form) [polypeptide binding]; other site 701177009825 ligand binding site [chemical binding]; other site 701177009826 diaminopimelate decarboxylase; Provisional; Region: PRK11165 701177009827 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 701177009828 active site 701177009829 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 701177009830 substrate binding site [chemical binding]; other site 701177009831 catalytic residues [active] 701177009832 dimer interface [polypeptide binding]; other site 701177009833 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 701177009834 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 701177009835 The C-terminal substrate binding domain of LysR, transcriptional regulator for lysine biosynthesis, contains the type 2 periplasmic binding fold; Region: PBP2_LysR; cd08456 701177009836 putative dimerization interface [polypeptide binding]; other site 701177009837 putative racemase; Provisional; Region: PRK10200 701177009838 aspartate racemase; Region: asp_race; TIGR00035 701177009839 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 701177009840 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177009841 putative substrate translocation pore; other site 701177009842 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177009843 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 701177009844 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 701177009845 NADP binding site [chemical binding]; other site 701177009846 homodimer interface [polypeptide binding]; other site 701177009847 active site 701177009848 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 701177009849 putative acyltransferase; Provisional; Region: PRK05790 701177009850 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 701177009851 dimer interface [polypeptide binding]; other site 701177009852 active site 701177009853 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 701177009854 serine transporter; Region: stp; TIGR00814 701177009855 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 701177009856 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 701177009857 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 701177009858 hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264 701177009859 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 701177009860 Tetratricopeptide repeat; Region: TPR_3; pfam07720 701177009861 Tetratricopeptide repeat; Region: TPR_3; pfam07720 701177009862 ATP synthase SpaL; Validated; Region: PRK08149 701177009863 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 701177009864 type III secretion system protein InvA; Provisional; Region: PRK15337 701177009865 type III secretion system regulator InvE; Provisional; Region: PRK15338 701177009866 HrpJ-like domain; Region: HrpJ; pfam07201 701177009867 type III secretion system outer membrane pore InvG; Provisional; Region: PRK15339 701177009868 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 701177009869 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 701177009870 transcriptional regulator InvF; Provisional; Region: PRK15340 701177009871 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 701177009872 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 701177009873 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 701177009874 Peptidase family M23; Region: Peptidase_M23; pfam01551 701177009875 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 701177009876 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 701177009877 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 701177009878 xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971 701177009879 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 701177009880 xanthine dehydrogenase subunit XdhC; Provisional; Region: PRK09908 701177009881 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 701177009882 catalytic loop [active] 701177009883 iron binding site [ion binding]; other site 701177009884 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 701177009885 GAF domain; Region: GAF; cl17456 701177009886 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 701177009887 PAS domain; Region: PAS; smart00091 701177009888 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 701177009889 Walker A motif; other site 701177009890 ATP binding site [chemical binding]; other site 701177009891 Walker B motif; other site 701177009892 arginine finger; other site 701177009893 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 701177009894 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 701177009895 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 701177009896 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 701177009897 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 701177009898 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 701177009899 catalytic residue [active] 701177009900 peptidase; Reviewed; Region: PRK13004 701177009901 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 701177009902 putative metal binding site [ion binding]; other site 701177009903 putative dimer interface [polypeptide binding]; other site 701177009904 D-hydantoinase; Region: D-hydantoinase; TIGR02033 701177009905 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 701177009906 tetramer interface [polypeptide binding]; other site 701177009907 active site 701177009908 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 701177009909 carbamate kinase; Reviewed; Region: PRK12686 701177009910 putative substrate binding site [chemical binding]; other site 701177009911 homodimer interface [polypeptide binding]; other site 701177009912 nucleotide binding site [chemical binding]; other site 701177009913 nucleotide binding site [chemical binding]; other site 701177009914 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 701177009915 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 701177009916 XdhC Rossmann domain; Region: XdhC_C; pfam13478 701177009917 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 701177009918 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 701177009919 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 701177009920 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 701177009921 Ligand binding site; other site 701177009922 metal-binding site 701177009923 putative selenate reductase subunit YgfK; Provisional; Region: PRK09853 701177009924 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 701177009925 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 701177009926 putative selenium metabolism protein SsnA; Region: Se_ssnA; TIGR03314 701177009927 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 701177009928 active site 701177009929 putative substrate binding pocket [chemical binding]; other site 701177009930 probable selenate reductase, FAD-binding subunit; Region: Se_sel_red_FAD; TIGR03312 701177009931 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 701177009932 putative hypoxanthine oxidase; Provisional; Region: PRK09800 701177009933 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 701177009934 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 701177009935 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 701177009936 uracil-xanthine permease; Region: ncs2; TIGR00801 701177009937 guanine deaminase; Provisional; Region: PRK09228 701177009938 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 701177009939 active site 701177009940 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 701177009941 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 701177009942 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12809 701177009943 4Fe-4S binding domain; Region: Fer4; pfam00037 701177009944 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 701177009945 xanthine permease; Region: pbuX; TIGR03173 701177009946 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 701177009947 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 701177009948 active site 701177009949 metal binding site [ion binding]; metal-binding site 701177009950 nudix motif; other site 701177009951 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 701177009952 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 701177009953 dimer interface [polypeptide binding]; other site 701177009954 putative anticodon binding site; other site 701177009955 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 701177009956 motif 1; other site 701177009957 active site 701177009958 motif 2; other site 701177009959 motif 3; other site 701177009960 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 701177009961 DHH family; Region: DHH; pfam01368 701177009962 DHHA1 domain; Region: DHHA1; pfam02272 701177009963 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 701177009964 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 701177009965 dimerization domain [polypeptide binding]; other site 701177009966 dimer interface [polypeptide binding]; other site 701177009967 catalytic residues [active] 701177009968 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 701177009969 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 701177009970 active site 701177009971 Int/Topo IB signature motif; other site 701177009972 flavodoxin FldB; Provisional; Region: PRK12359 701177009973 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 701177009974 hypothetical protein; Provisional; Region: PRK10878 701177009975 putative global regulator; Reviewed; Region: PRK09559 701177009976 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 701177009977 hemolysin; Provisional; Region: PRK15087 701177009978 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 701177009979 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 701177009980 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 701177009981 beta-galactosidase; Region: BGL; TIGR03356 701177009982 glycine dehydrogenase; Provisional; Region: PRK05367 701177009983 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 701177009984 tetramer interface [polypeptide binding]; other site 701177009985 pyridoxal 5'-phosphate binding site [chemical binding]; other site 701177009986 catalytic residue [active] 701177009987 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 701177009988 tetramer interface [polypeptide binding]; other site 701177009989 pyridoxal 5'-phosphate binding site [chemical binding]; other site 701177009990 catalytic residue [active] 701177009991 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 701177009992 lipoyl attachment site [posttranslational modification]; other site 701177009993 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 701177009994 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 701177009995 oxidoreductase; Provisional; Region: PRK08013 701177009996 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 701177009997 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 701177009998 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 701177009999 proline aminopeptidase P II; Provisional; Region: PRK10879 701177010000 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 701177010001 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 701177010002 active site 701177010003 hypothetical protein; Reviewed; Region: PRK01736 701177010004 Z-ring-associated protein; Provisional; Region: PRK10972 701177010005 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 701177010006 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 701177010007 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 701177010008 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 701177010009 ligand binding site [chemical binding]; other site 701177010010 NAD binding site [chemical binding]; other site 701177010011 tetramer interface [polypeptide binding]; other site 701177010012 catalytic site [active] 701177010013 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 701177010014 L-serine binding site [chemical binding]; other site 701177010015 ACT domain interface; other site 701177010016 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 701177010017 tetramer (dimer of dimers) interface [polypeptide binding]; other site 701177010018 active site 701177010019 dimer interface [polypeptide binding]; other site 701177010020 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 701177010021 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 701177010022 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 701177010023 putative dimerization interface [polypeptide binding]; other site 701177010024 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 701177010025 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 701177010026 active site 701177010027 substrate binding site [chemical binding]; other site 701177010028 coenzyme B12 binding site [chemical binding]; other site 701177010029 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 701177010030 B12 binding site [chemical binding]; other site 701177010031 cobalt ligand [ion binding]; other site 701177010032 membrane ATPase/protein kinase; Provisional; Region: PRK09435 701177010033 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 701177010034 Walker A; other site 701177010035 methylmalonyl-CoA decarboxylase; Provisional; Region: PRK11423 701177010036 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 701177010037 substrate binding site [chemical binding]; other site 701177010038 oxyanion hole (OAH) forming residues; other site 701177010039 trimer interface [polypeptide binding]; other site 701177010040 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 701177010041 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 701177010042 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 701177010043 Uncharacterized conserved protein [Function unknown]; Region: COG2968 701177010044 oxidative stress defense protein; Provisional; Region: PRK11087 701177010045 arginine exporter protein; Provisional; Region: PRK09304 701177010046 mechanosensitive channel MscS; Provisional; Region: PRK10334 701177010047 Mechanosensitive ion channel; Region: MS_channel; pfam00924 701177010048 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 701177010049 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 701177010050 active site 701177010051 intersubunit interface [polypeptide binding]; other site 701177010052 zinc binding site [ion binding]; other site 701177010053 Na+ binding site [ion binding]; other site 701177010054 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 701177010055 Phosphoglycerate kinase; Region: PGK; pfam00162 701177010056 substrate binding site [chemical binding]; other site 701177010057 hinge regions; other site 701177010058 ADP binding site [chemical binding]; other site 701177010059 catalytic site [active] 701177010060 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 701177010061 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 701177010062 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 701177010063 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 701177010064 trimer interface [polypeptide binding]; other site 701177010065 putative Zn binding site [ion binding]; other site 701177010066 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 701177010067 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 701177010068 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 701177010069 Walker A/P-loop; other site 701177010070 ATP binding site [chemical binding]; other site 701177010071 Q-loop/lid; other site 701177010072 ABC transporter signature motif; other site 701177010073 Walker B; other site 701177010074 D-loop; other site 701177010075 H-loop/switch region; other site 701177010076 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 701177010077 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 701177010078 Walker A/P-loop; other site 701177010079 ATP binding site [chemical binding]; other site 701177010080 Q-loop/lid; other site 701177010081 ABC transporter signature motif; other site 701177010082 Walker B; other site 701177010083 D-loop; other site 701177010084 H-loop/switch region; other site 701177010085 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 701177010086 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 701177010087 active site 701177010088 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 701177010089 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10022 701177010090 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 701177010091 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 701177010092 putative active site [active] 701177010093 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 701177010094 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 701177010095 putative NAD(P) binding site [chemical binding]; other site 701177010096 catalytic Zn binding site [ion binding]; other site 701177010097 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 701177010098 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 701177010099 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 701177010100 active site 701177010101 P-loop; other site 701177010102 phosphorylation site [posttranslational modification] 701177010103 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 701177010104 active site 701177010105 phosphorylation site [posttranslational modification] 701177010106 transketolase; Reviewed; Region: PRK12753 701177010107 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 701177010108 TPP-binding site [chemical binding]; other site 701177010109 dimer interface [polypeptide binding]; other site 701177010110 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 701177010111 PYR/PP interface [polypeptide binding]; other site 701177010112 dimer interface [polypeptide binding]; other site 701177010113 TPP binding site [chemical binding]; other site 701177010114 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 701177010115 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 701177010116 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 701177010117 agmatinase; Region: agmatinase; TIGR01230 701177010118 oligomer interface [polypeptide binding]; other site 701177010119 putative active site [active] 701177010120 Mn binding site [ion binding]; other site 701177010121 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 701177010122 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 701177010123 dimer interface [polypeptide binding]; other site 701177010124 active site 701177010125 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 701177010126 catalytic residues [active] 701177010127 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 701177010128 Virulence promoting factor; Region: YqgB; pfam11036 701177010129 Protein of unknown function (DUF2684); Region: DUF2684; pfam10885 701177010130 S-adenosylmethionine synthetase; Validated; Region: PRK05250 701177010131 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 701177010132 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 701177010133 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 701177010134 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 701177010135 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177010136 putative substrate translocation pore; other site 701177010137 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177010138 hypothetical protein; Provisional; Region: PRK04860 701177010139 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 701177010140 DNA-specific endonuclease I; Provisional; Region: PRK15137 701177010141 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 701177010142 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 701177010143 RNA methyltransferase, RsmE family; Region: TIGR00046 701177010144 glutathione synthetase; Provisional; Region: PRK05246 701177010145 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 701177010146 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 701177010147 hypothetical protein; Validated; Region: PRK00228 701177010148 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 701177010149 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 701177010150 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 701177010151 Walker A motif; other site 701177010152 ATP binding site [chemical binding]; other site 701177010153 Walker B motif; other site 701177010154 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 701177010155 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 701177010156 catalytic residue [active] 701177010157 YGGT family; Region: YGGT; pfam02325 701177010158 YGGT family; Region: YGGT; pfam02325 701177010159 hypothetical protein; Validated; Region: PRK05090 701177010160 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 701177010161 active site 701177010162 dimerization interface [polypeptide binding]; other site 701177010163 HemN family oxidoreductase; Provisional; Region: PRK05660 701177010164 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 701177010165 FeS/SAM binding site; other site 701177010166 HemN C-terminal domain; Region: HemN_C; pfam06969 701177010167 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 701177010168 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 701177010169 homodimer interface [polypeptide binding]; other site 701177010170 active site 701177010171 hypothetical protein; Provisional; Region: PRK10626 701177010172 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 701177010173 hypothetical protein; Provisional; Region: PRK11702 701177010174 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 701177010175 adenine DNA glycosylase; Provisional; Region: PRK10880 701177010176 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 701177010177 minor groove reading motif; other site 701177010178 helix-hairpin-helix signature motif; other site 701177010179 substrate binding pocket [chemical binding]; other site 701177010180 active site 701177010181 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 701177010182 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 701177010183 DNA binding and oxoG recognition site [nucleotide binding] 701177010184 oxidative damage protection protein; Provisional; Region: PRK05408 701177010185 murein transglycosylase C; Provisional; Region: mltC; PRK11671 701177010186 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 701177010187 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 701177010188 N-acetyl-D-glucosamine binding site [chemical binding]; other site 701177010189 catalytic residue [active] 701177010190 nucleoside transporter; Region: 2A0110; TIGR00889 701177010191 ornithine decarboxylase; Provisional; Region: PRK13578 701177010192 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 701177010193 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 701177010194 homodimer interface [polypeptide binding]; other site 701177010195 pyridoxal 5'-phosphate binding site [chemical binding]; other site 701177010196 catalytic residue [active] 701177010197 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 701177010198 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 701177010199 integrase; Provisional; Region: PRK09692 701177010200 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 701177010201 active site 701177010202 Int/Topo IB signature motif; other site 701177010203 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 701177010204 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 701177010205 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 701177010206 Homeodomain-like domain; Region: HTH_23; pfam13384 701177010207 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 701177010208 Transposase; Region: HTH_Tnp_1; pfam01527 701177010209 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 701177010210 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 701177010211 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 701177010212 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 701177010213 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 701177010214 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 701177010215 Nuclease-related domain; Region: NERD; pfam08378 701177010216 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 701177010217 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 701177010218 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 701177010219 DDE superfamily endonuclease; Region: DDE_3; pfam13358 701177010220 TcdB toxin N-terminal helical domain; Region: TcdB_N; pfam12918 701177010221 TcdA/TcdB catalytic glycosyltransferase domain; Region: TcdA_TcdB; pfam12919 701177010222 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 701177010223 cysteine protease domain, YopT-type; Region: yopT_cys_prot; TIGR01586 701177010224 Protein of unknown function (DUF3491); Region: DUF3491; pfam11996 701177010225 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 701177010226 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 701177010227 Transposase; Region: HTH_Tnp_1; pfam01527 701177010228 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 701177010229 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 701177010230 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 701177010231 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 701177010232 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 701177010233 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 701177010234 Integrase core domain; Region: rve_2; pfam13333 701177010235 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 701177010236 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 701177010237 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 701177010238 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 701177010239 Haemolysin expression modulating protein; Region: HHA; cl11501 701177010240 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 701177010241 Transposase; Region: HTH_Tnp_1; cl17663 701177010242 putative transposase OrfB; Reviewed; Region: PHA02517 701177010243 HTH-like domain; Region: HTH_21; pfam13276 701177010244 Integrase core domain; Region: rve; pfam00665 701177010245 Integrase core domain; Region: rve_3; pfam13683 701177010246 Predicted GTPase [General function prediction only]; Region: COG3596 701177010247 YfjP GTPase; Region: YfjP; cd11383 701177010248 G1 box; other site 701177010249 GTP/Mg2+ binding site [chemical binding]; other site 701177010250 Switch I region; other site 701177010251 G2 box; other site 701177010252 Switch II region; other site 701177010253 G3 box; other site 701177010254 G4 box; other site 701177010255 G5 box; other site 701177010256 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 701177010257 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 701177010258 hypothetical protein; Provisional; Region: PRK09945 701177010259 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 701177010260 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 701177010261 Autotransporter beta-domain; Region: Autotransporter; smart00869 701177010262 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 701177010263 Transposase; Region: HTH_Tnp_1; cl17663 701177010264 Integrase core domain; Region: rve; pfam00665 701177010265 DDE domain; Region: DDE_Tnp_IS240; pfam13610 701177010266 Integrase core domain; Region: rve_3; pfam13683 701177010267 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 701177010268 Domain of unknown function (DUF932); Region: DUF932; pfam06067 701177010269 Antirestriction protein; Region: Antirestrict; pfam03230 701177010270 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 701177010271 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 701177010272 MPN+ (JAMM) motif; other site 701177010273 Zinc-binding site [ion binding]; other site 701177010274 Protein of unknown function (DUF987); Region: DUF987; pfam06174 701177010275 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 701177010276 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 701177010277 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 701177010278 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 701177010279 DNA binding residues [nucleotide binding] 701177010280 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 701177010281 Integrase core domain; Region: rve; pfam00665 701177010282 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 701177010283 IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483 701177010284 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 701177010285 Walker A motif; other site 701177010286 ATP binding site [chemical binding]; other site 701177010287 Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117 701177010288 Methyltransferase domain; Region: Methyltransf_27; pfam13708 701177010289 putative general secretion pathway protein YghD; Provisional; Region: PRK09731 701177010290 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 701177010291 GspL-like protein; Provisional; Region: PRK09662 701177010292 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 701177010293 type II secretion system protein J; Region: gspJ; TIGR01711 701177010294 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 701177010295 type II secretion system protein I; Region: gspI; TIGR01707 701177010296 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 701177010297 Prokaryotic N-terminal methylation motif; Region: N_methyl; pfam07963 701177010298 Type II transport protein GspH; Region: GspH; pfam12019 701177010299 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 701177010300 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 701177010301 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 701177010302 type II secretion system protein F; Region: GspF; TIGR02120 701177010303 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 701177010304 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 701177010305 type II secretion system protein E; Region: type_II_gspE; TIGR02533 701177010306 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 701177010307 Walker A motif; other site 701177010308 ATP binding site [chemical binding]; other site 701177010309 Walker B motif; other site 701177010310 type II secretion system protein D; Region: type_II_gspD; TIGR02517 701177010311 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 701177010312 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 701177010313 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 701177010314 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 701177010315 putative type II secretion protein GspC; Provisional; Region: PRK09681 701177010316 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 701177010317 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 701177010318 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 701177010319 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 701177010320 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 701177010321 Domain of unknown function (DUF4092); Region: DUF4092; pfam13322 701177010322 Peptidase M60-like family; Region: M60-like; pfam13402 701177010323 glycolate transporter; Provisional; Region: PRK09695 701177010324 L-lactate permease; Region: Lactate_perm; cl00701 701177010325 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 701177010326 active site 701177010327 hypothetical protein; Provisional; Region: PRK09732 701177010328 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 701177010329 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 701177010330 Cysteine-rich domain; Region: CCG; pfam02754 701177010331 Cysteine-rich domain; Region: CCG; pfam02754 701177010332 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 701177010333 FAD binding domain; Region: FAD_binding_4; pfam01565 701177010334 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 701177010335 FAD binding domain; Region: FAD_binding_4; pfam01565 701177010336 DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990 701177010337 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 701177010338 DNA-binding site [nucleotide binding]; DNA binding site 701177010339 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 701177010340 acyl-CoA synthetase; Validated; Region: PRK09192 701177010341 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 701177010342 acyl-activating enzyme (AAE) consensus motif; other site 701177010343 active site 701177010344 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 701177010345 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 701177010346 NAD(P) binding site [chemical binding]; other site 701177010347 active site 701177010348 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 701177010349 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 701177010350 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 701177010351 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 701177010352 catalytic residue [active] 701177010353 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 701177010354 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 701177010355 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 701177010356 Predicted permeases [General function prediction only]; Region: COG0795 701177010357 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; pfam09695 701177010358 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 701177010359 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 701177010360 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 701177010361 active site 701177010362 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 701177010363 TMP-binding site; other site 701177010364 ATP-binding site [chemical binding]; other site 701177010365 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 701177010366 active site 701177010367 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 701177010368 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 701177010369 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 701177010370 CHAP domain; Region: CHAP; pfam05257 701177010371 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 701177010372 putative S-transferase; Provisional; Region: PRK11752 701177010373 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 701177010374 C-terminal domain interface [polypeptide binding]; other site 701177010375 GSH binding site (G-site) [chemical binding]; other site 701177010376 dimer interface [polypeptide binding]; other site 701177010377 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 701177010378 dimer interface [polypeptide binding]; other site 701177010379 N-terminal domain interface [polypeptide binding]; other site 701177010380 active site 701177010381 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 701177010382 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 701177010383 hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380 701177010384 hydrogenase 2-specific chaperone; Provisional; Region: PRK10465 701177010385 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 701177010386 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 701177010387 putative substrate-binding site; other site 701177010388 nickel binding site [ion binding]; other site 701177010389 hydrogenase 2 large subunit; Provisional; Region: PRK10467 701177010390 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 701177010391 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 701177010392 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 701177010393 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 701177010394 4Fe-4S binding domain; Region: Fer4_6; pfam12837 701177010395 hydrogenase 2 small subunit; Provisional; Region: PRK10468 701177010396 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 701177010397 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 701177010398 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 701177010399 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 701177010400 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 701177010401 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 701177010402 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 701177010403 active site 701177010404 catalytic tetrad [active] 701177010405 hypothetical protein; Provisional; Region: PRK05208 701177010406 oxidoreductase; Provisional; Region: PRK07985 701177010407 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 701177010408 NAD binding site [chemical binding]; other site 701177010409 metal binding site [ion binding]; metal-binding site 701177010410 active site 701177010411 biopolymer transport protein ExbD; Provisional; Region: PRK11267 701177010412 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 701177010413 biopolymer transport protein ExbB; Provisional; Region: PRK10414 701177010414 cystathionine beta-lyase; Provisional; Region: PRK08114 701177010415 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 701177010416 homodimer interface [polypeptide binding]; other site 701177010417 substrate-cofactor binding pocket; other site 701177010418 pyridoxal 5'-phosphate binding site [chemical binding]; other site 701177010419 catalytic residue [active] 701177010420 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 701177010421 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 701177010422 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 701177010423 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 701177010424 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 701177010425 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 701177010426 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 701177010427 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 701177010428 dimer interface [polypeptide binding]; other site 701177010429 active site 701177010430 metal binding site [ion binding]; metal-binding site 701177010431 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 701177010432 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 701177010433 active site 701177010434 catalytic tetrad [active] 701177010435 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 701177010436 putative outer membrane lipoprotein; Provisional; Region: PRK09973 701177010437 hypothetical protein; Provisional; Region: PRK01254 701177010438 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 701177010439 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 701177010440 FtsI repressor; Provisional; Region: PRK10883 701177010441 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 701177010442 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 701177010443 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 701177010444 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 701177010445 putative acyl-acceptor binding pocket; other site 701177010446 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 701177010447 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 701177010448 CAP-like domain; other site 701177010449 active site 701177010450 primary dimer interface [polypeptide binding]; other site 701177010451 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 701177010452 putative ABC transporter periplasmic-binding protein; Provisional; Region: PRK09755 701177010453 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 701177010454 peptide binding site [polypeptide binding]; other site 701177010455 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 701177010456 TIGR00156 family protein; Region: TIGR00156 701177010457 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 701177010458 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 701177010459 active site 701177010460 phosphorylation site [posttranslational modification] 701177010461 intermolecular recognition site; other site 701177010462 dimerization interface [polypeptide binding]; other site 701177010463 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 701177010464 DNA binding site [nucleotide binding] 701177010465 sensor protein QseC; Provisional; Region: PRK10337 701177010466 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 701177010467 dimer interface [polypeptide binding]; other site 701177010468 phosphorylation site [posttranslational modification] 701177010469 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 701177010470 ATP binding site [chemical binding]; other site 701177010471 Mg2+ binding site [ion binding]; other site 701177010472 G-X-G motif; other site 701177010473 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 701177010474 Uncharacterized conserved protein [Function unknown]; Region: COG1359 701177010475 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 701177010476 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 701177010477 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cd04795 701177010478 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 701177010479 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 701177010480 siderophore binding site; other site 701177010481 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 701177010482 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 701177010483 ABC-ATPase subunit interface; other site 701177010484 dimer interface [polypeptide binding]; other site 701177010485 putative PBP binding regions; other site 701177010486 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 701177010487 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 701177010488 dimer interface [polypeptide binding]; other site 701177010489 putative PBP binding regions; other site 701177010490 ABC-ATPase subunit interface; other site 701177010491 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 701177010492 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 701177010493 Walker A/P-loop; other site 701177010494 ATP binding site [chemical binding]; other site 701177010495 Q-loop/lid; other site 701177010496 ABC transporter signature motif; other site 701177010497 Walker B; other site 701177010498 D-loop; other site 701177010499 H-loop/switch region; other site 701177010500 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 701177010501 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 701177010502 N-terminal plug; other site 701177010503 ligand-binding site [chemical binding]; other site 701177010504 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 701177010505 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 701177010506 ATP binding site [chemical binding]; other site 701177010507 Mg2+ binding site [ion binding]; other site 701177010508 G-X-G motif; other site 701177010509 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 701177010510 anchoring element; other site 701177010511 dimer interface [polypeptide binding]; other site 701177010512 ATP binding site [chemical binding]; other site 701177010513 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 701177010514 active site 701177010515 metal binding site [ion binding]; metal-binding site 701177010516 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 701177010517 esterase YqiA; Provisional; Region: PRK11071 701177010518 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 701177010519 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 701177010520 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 701177010521 active site 701177010522 metal binding site [ion binding]; metal-binding site 701177010523 hexamer interface [polypeptide binding]; other site 701177010524 putative dehydrogenase; Provisional; Region: PRK11039 701177010525 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 701177010526 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 701177010527 dimer interface [polypeptide binding]; other site 701177010528 ADP-ribose binding site [chemical binding]; other site 701177010529 active site 701177010530 nudix motif; other site 701177010531 metal binding site [ion binding]; metal-binding site 701177010532 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 701177010533 hypothetical protein; Provisional; Region: PRK11653 701177010534 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 701177010535 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 701177010536 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 701177010537 putative active site [active] 701177010538 metal binding site [ion binding]; metal-binding site 701177010539 zinc transporter ZupT; Provisional; Region: PRK04201 701177010540 ZIP Zinc transporter; Region: Zip; pfam02535 701177010541 Protein of unknown function (DUF4051); Region: DUF4051; pfam13260 701177010542 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 701177010543 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 701177010544 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 701177010545 glycogen synthesis protein GlgS; Provisional; Region: PRK02922 701177010546 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 701177010547 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 701177010548 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 701177010549 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 701177010550 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 701177010551 putative ribose interaction site [chemical binding]; other site 701177010552 putative ADP binding site [chemical binding]; other site 701177010553 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 701177010554 active site 701177010555 nucleotide binding site [chemical binding]; other site 701177010556 HIGH motif; other site 701177010557 KMSKS motif; other site 701177010558 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 701177010559 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 701177010560 metal binding triad; other site 701177010561 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 701177010562 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 701177010563 metal binding triad; other site 701177010564 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 701177010565 Uncharacterized conserved protein [Function unknown]; Region: COG3025 701177010566 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 701177010567 putative active site [active] 701177010568 putative metal binding residues [ion binding]; other site 701177010569 signature motif; other site 701177010570 putative triphosphate binding site [ion binding]; other site 701177010571 CHAD domain; Region: CHAD; pfam05235 701177010572 SH3 domain-containing protein; Provisional; Region: PRK10884 701177010573 Bacterial SH3 domain homologues; Region: SH3b; smart00287 701177010574 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 701177010575 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 701177010576 active site 701177010577 NTP binding site [chemical binding]; other site 701177010578 metal binding triad [ion binding]; metal-binding site 701177010579 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 701177010580 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 701177010581 Zn2+ binding site [ion binding]; other site 701177010582 Mg2+ binding site [ion binding]; other site 701177010583 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 701177010584 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 701177010585 homooctamer interface [polypeptide binding]; other site 701177010586 active site 701177010587 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 701177010588 transcriptional activator TtdR; Provisional; Region: PRK09801 701177010589 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 701177010590 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 701177010591 putative effector binding pocket; other site 701177010592 putative dimerization interface [polypeptide binding]; other site 701177010593 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 701177010594 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 701177010595 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 701177010596 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 701177010597 transmembrane helices; other site 701177010598 UGMP family protein; Validated; Region: PRK09604 701177010599 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 701177010600 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 701177010601 DNA primase; Validated; Region: dnaG; PRK05667 701177010602 CHC2 zinc finger; Region: zf-CHC2; pfam01807 701177010603 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 701177010604 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 701177010605 active site 701177010606 metal binding site [ion binding]; metal-binding site 701177010607 interdomain interaction site; other site 701177010608 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 701177010609 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 701177010610 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 701177010611 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 701177010612 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 701177010613 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 701177010614 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 701177010615 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 701177010616 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 701177010617 DNA binding residues [nucleotide binding] 701177010618 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 701177010619 active site 701177010620 SUMO-1 interface [polypeptide binding]; other site 701177010621 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 701177010622 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 701177010623 FAD binding pocket [chemical binding]; other site 701177010624 FAD binding motif [chemical binding]; other site 701177010625 phosphate binding motif [ion binding]; other site 701177010626 NAD binding pocket [chemical binding]; other site 701177010627 Predicted transcriptional regulators [Transcription]; Region: COG1695 701177010628 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 701177010629 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 701177010630 PAS fold; Region: PAS_3; pfam08447 701177010631 putative active site [active] 701177010632 heme pocket [chemical binding]; other site 701177010633 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 701177010634 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 701177010635 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 701177010636 dimer interface [polypeptide binding]; other site 701177010637 putative CheW interface [polypeptide binding]; other site 701177010638 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 701177010639 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 701177010640 inhibitor-cofactor binding pocket; inhibition site 701177010641 pyridoxal 5'-phosphate binding site [chemical binding]; other site 701177010642 catalytic residue [active] 701177010643 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 701177010644 dimer interface [polypeptide binding]; other site 701177010645 putative tRNA-binding site [nucleotide binding]; other site 701177010646 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 701177010647 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 701177010648 DNA binding site [nucleotide binding] 701177010649 domain linker motif; other site 701177010650 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 701177010651 putative dimerization interface [polypeptide binding]; other site 701177010652 putative ligand binding site [chemical binding]; other site 701177010653 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 701177010654 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 701177010655 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 701177010656 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 701177010657 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 701177010658 cryptic beta-D-galactosidase subunit beta; Reviewed; Region: ebgC; PRK10202 701177010659 inner membrane transporter YjeM; Provisional; Region: PRK15238 701177010660 alpha-glucosidase; Provisional; Region: PRK10137 701177010661 Protein of unknown function, DUF608; Region: DUF608; pfam04685 701177010662 Trehalase; Region: Trehalase; cl17346 701177010663 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 701177010664 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 701177010665 active site 701177010666 FMN binding site [chemical binding]; other site 701177010667 2,4-decadienoyl-CoA binding site; other site 701177010668 catalytic residue [active] 701177010669 4Fe-4S cluster binding site [ion binding]; other site 701177010670 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 701177010671 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 701177010672 non-specific DNA binding site [nucleotide binding]; other site 701177010673 salt bridge; other site 701177010674 sequence-specific DNA binding site [nucleotide binding]; other site 701177010675 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4680 701177010676 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 701177010677 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 701177010678 S-adenosylmethionine binding site [chemical binding]; other site 701177010679 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 701177010680 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 701177010681 putative active site [active] 701177010682 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 701177010683 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 701177010684 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 701177010685 serine/threonine transporter SstT; Provisional; Region: PRK13628 701177010686 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 701177010687 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 701177010688 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 701177010689 galactarate dehydratase; Region: galactar-dH20; TIGR03248 701177010690 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 701177010691 Glucuronate isomerase; Region: UxaC; pfam02614 701177010692 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 701177010693 D-galactonate transporter; Region: 2A0114; TIGR00893 701177010694 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177010695 putative substrate translocation pore; other site 701177010696 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 701177010697 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 701177010698 DNA-binding site [nucleotide binding]; DNA binding site 701177010699 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 701177010700 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 701177010701 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 701177010702 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 701177010703 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 701177010704 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 701177010705 Predicted membrane protein [Function unknown]; Region: COG5393 701177010706 YqjK-like protein; Region: YqjK; pfam13997 701177010707 Predicted membrane protein [Function unknown]; Region: COG2259 701177010708 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 701177010709 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 701177010710 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 701177010711 putative dimer interface [polypeptide binding]; other site 701177010712 N-terminal domain interface [polypeptide binding]; other site 701177010713 putative substrate binding pocket (H-site) [chemical binding]; other site 701177010714 Predicted membrane protein [Function unknown]; Region: COG3152 701177010715 Predicted membrane protein [Function unknown]; Region: COG3152 701177010716 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 701177010717 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 701177010718 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 701177010719 dimerization interface [polypeptide binding]; other site 701177010720 Pirin-related protein [General function prediction only]; Region: COG1741 701177010721 Pirin; Region: Pirin; pfam02678 701177010722 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 701177010723 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 701177010724 serine transporter; Region: stp; TIGR00814 701177010725 L-serine dehydratase TdcG; Provisional; Region: PRK15040 701177010726 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 701177010727 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 701177010728 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 701177010729 homotrimer interaction site [polypeptide binding]; other site 701177010730 putative active site [active] 701177010731 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 701177010732 Pyruvate formate lyase 1; Region: PFL1; cd01678 701177010733 coenzyme A binding site [chemical binding]; other site 701177010734 active site 701177010735 catalytic residues [active] 701177010736 glycine loop; other site 701177010737 propionate/acetate kinase; Provisional; Region: PRK12379 701177010738 Acetokinase family; Region: Acetate_kinase; cl17229 701177010739 threonine/serine transporter TdcC; Provisional; Region: PRK13629 701177010740 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 701177010741 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 701177010742 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 701177010743 tetramer interface [polypeptide binding]; other site 701177010744 pyridoxal 5'-phosphate binding site [chemical binding]; other site 701177010745 catalytic residue [active] 701177010746 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 701177010747 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 701177010748 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 701177010749 putative substrate binding pocket [chemical binding]; other site 701177010750 putative dimerization interface [polypeptide binding]; other site 701177010751 DNA-binding transcriptional activator TdcR; Provisional; Region: PRK11424 701177010752 hypothetical protein; Provisional; Region: PRK09716 701177010753 glycerate kinase I; Provisional; Region: PRK10342 701177010754 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 701177010755 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 701177010756 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 701177010757 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177010758 D-galactonate transporter; Region: 2A0114; TIGR00893 701177010759 putative substrate translocation pore; other site 701177010760 galactarate dehydratase; Region: galactar-dH20; TIGR03248 701177010761 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 701177010762 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 701177010763 putative regulator PrlF; Provisional; Region: PRK09974 701177010764 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 701177010765 Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663 701177010766 DNA-binding transcriptional regulator AgaR; Provisional; Region: PRK09802 701177010767 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 701177010768 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 701177010769 tagatose 6-phosphate aldolase subunit KbaZ; Provisional; Region: PRK15458 701177010770 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 701177010771 active site 701177010772 phosphorylation site [posttranslational modification] 701177010773 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 701177010774 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 701177010775 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 701177010776 active pocket/dimerization site; other site 701177010777 active site 701177010778 phosphorylation site [posttranslational modification] 701177010779 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 701177010780 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 701177010781 active site 701177010782 dimer interface [polypeptide binding]; other site 701177010783 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 701177010784 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 701177010785 dimer interface [polypeptide binding]; other site 701177010786 active site 701177010787 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 701177010788 putative active site [active] 701177010789 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cd00453 701177010790 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 701177010791 active site 701177010792 intersubunit interface [polypeptide binding]; other site 701177010793 zinc binding site [ion binding]; other site 701177010794 Na+ binding site [ion binding]; other site 701177010795 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 701177010796 active site 701177010797 phosphorylation site [posttranslational modification] 701177010798 PTS system N-acetylgalactosamine-specific transporter subunit IIC; Provisional; Region: PRK09757 701177010799 PTS system N-acetylgalactosamine-specific transporter subunit IID; Provisional; Region: PRK09855 701177010800 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 701177010801 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 701177010802 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 701177010803 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 701177010804 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 701177010805 PapC N-terminal domain; Region: PapC_N; pfam13954 701177010806 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 701177010807 PapC C-terminal domain; Region: PapC_C; pfam13953 701177010808 Fimbrial protein; Region: Fimbrial; pfam00419 701177010809 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 701177010810 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 701177010811 putative SAM binding site [chemical binding]; other site 701177010812 putative homodimer interface [polypeptide binding]; other site 701177010813 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 701177010814 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 701177010815 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 701177010816 putative ligand binding site [chemical binding]; other site 701177010817 TIGR00252 family protein; Region: TIGR00252 701177010818 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 701177010819 dimer interface [polypeptide binding]; other site 701177010820 active site 701177010821 outer membrane lipoprotein; Provisional; Region: PRK11023 701177010822 BON domain; Region: BON; pfam04972 701177010823 BON domain; Region: BON; pfam04972 701177010824 Predicted permease; Region: DUF318; pfam03773 701177010825 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 701177010826 NADH(P)-binding; Region: NAD_binding_10; pfam13460 701177010827 NAD binding site [chemical binding]; other site 701177010828 active site 701177010829 intracellular protease, PfpI family; Region: PfpI; TIGR01382 701177010830 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 701177010831 proposed catalytic triad [active] 701177010832 conserved cys residue [active] 701177010833 hypothetical protein; Provisional; Region: PRK03467 701177010834 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 701177010835 GIY-YIG motif/motif A; other site 701177010836 putative active site [active] 701177010837 putative metal binding site [ion binding]; other site 701177010838 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 701177010839 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 701177010840 Coenzyme A binding pocket [chemical binding]; other site 701177010841 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 701177010842 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 701177010843 Peptidase family U32; Region: Peptidase_U32; pfam01136 701177010844 putative protease; Provisional; Region: PRK15447 701177010845 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 701177010846 hypothetical protein; Provisional; Region: PRK10508 701177010847 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 701177010848 tryptophan permease; Provisional; Region: PRK10483 701177010849 aromatic amino acid transport protein; Region: araaP; TIGR00837 701177010850 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 701177010851 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 701177010852 ATP binding site [chemical binding]; other site 701177010853 Mg++ binding site [ion binding]; other site 701177010854 motif III; other site 701177010855 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 701177010856 nucleotide binding region [chemical binding]; other site 701177010857 ATP-binding site [chemical binding]; other site 701177010858 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 701177010859 putative RNA binding site [nucleotide binding]; other site 701177010860 lipoprotein NlpI; Provisional; Region: PRK11189 701177010861 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 701177010862 binding surface 701177010863 TPR motif; other site 701177010864 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 701177010865 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 701177010866 RNase E interface [polypeptide binding]; other site 701177010867 trimer interface [polypeptide binding]; other site 701177010868 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 701177010869 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 701177010870 RNase E interface [polypeptide binding]; other site 701177010871 trimer interface [polypeptide binding]; other site 701177010872 active site 701177010873 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 701177010874 putative nucleic acid binding region [nucleotide binding]; other site 701177010875 G-X-X-G motif; other site 701177010876 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 701177010877 RNA binding site [nucleotide binding]; other site 701177010878 domain interface; other site 701177010879 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 701177010880 16S/18S rRNA binding site [nucleotide binding]; other site 701177010881 S13e-L30e interaction site [polypeptide binding]; other site 701177010882 25S rRNA binding site [nucleotide binding]; other site 701177010883 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 701177010884 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 701177010885 RNA binding site [nucleotide binding]; other site 701177010886 active site 701177010887 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 701177010888 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 701177010889 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 701177010890 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 701177010891 translation initiation factor IF-2; Region: IF-2; TIGR00487 701177010892 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 701177010893 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 701177010894 G1 box; other site 701177010895 putative GEF interaction site [polypeptide binding]; other site 701177010896 GTP/Mg2+ binding site [chemical binding]; other site 701177010897 Switch I region; other site 701177010898 G2 box; other site 701177010899 G3 box; other site 701177010900 Switch II region; other site 701177010901 G4 box; other site 701177010902 G5 box; other site 701177010903 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 701177010904 Translation-initiation factor 2; Region: IF-2; pfam11987 701177010905 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 701177010906 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 701177010907 NusA N-terminal domain; Region: NusA_N; pfam08529 701177010908 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 701177010909 RNA binding site [nucleotide binding]; other site 701177010910 homodimer interface [polypeptide binding]; other site 701177010911 NusA-like KH domain; Region: KH_5; pfam13184 701177010912 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 701177010913 G-X-X-G motif; other site 701177010914 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 701177010915 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 701177010916 ribosome maturation protein RimP; Reviewed; Region: PRK00092 701177010917 Sm and related proteins; Region: Sm_like; cl00259 701177010918 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 701177010919 putative oligomer interface [polypeptide binding]; other site 701177010920 putative RNA binding site [nucleotide binding]; other site 701177010921 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 701177010922 ANP binding site [chemical binding]; other site 701177010923 Substrate Binding Site II [chemical binding]; other site 701177010924 Substrate Binding Site I [chemical binding]; other site 701177010925 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 701177010926 Sulfatase; Region: Sulfatase; pfam00884 701177010927 Preprotein translocase SecG subunit; Region: SecG; pfam03840 701177010928 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 701177010929 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 701177010930 active site 701177010931 substrate binding site [chemical binding]; other site 701177010932 metal binding site [ion binding]; metal-binding site 701177010933 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 701177010934 dihydropteroate synthase; Region: DHPS; TIGR01496 701177010935 substrate binding pocket [chemical binding]; other site 701177010936 dimer interface [polypeptide binding]; other site 701177010937 inhibitor binding site; inhibition site 701177010938 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 701177010939 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 701177010940 Walker A motif; other site 701177010941 ATP binding site [chemical binding]; other site 701177010942 Walker B motif; other site 701177010943 arginine finger; other site 701177010944 Peptidase family M41; Region: Peptidase_M41; pfam01434 701177010945 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 701177010946 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 701177010947 S-adenosylmethionine binding site [chemical binding]; other site 701177010948 RNA-binding protein YhbY; Provisional; Region: PRK10343 701177010949 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 701177010950 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 701177010951 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 701177010952 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 701177010953 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 701177010954 GTPase CgtA; Reviewed; Region: obgE; PRK12298 701177010955 GTP1/OBG; Region: GTP1_OBG; pfam01018 701177010956 Obg GTPase; Region: Obg; cd01898 701177010957 G1 box; other site 701177010958 GTP/Mg2+ binding site [chemical binding]; other site 701177010959 Switch I region; other site 701177010960 G2 box; other site 701177010961 G3 box; other site 701177010962 Switch II region; other site 701177010963 G4 box; other site 701177010964 G5 box; other site 701177010965 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 701177010966 EamA-like transporter family; Region: EamA; pfam00892 701177010967 EamA-like transporter family; Region: EamA; pfam00892 701177010968 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 701177010969 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 701177010970 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 701177010971 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 701177010972 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 701177010973 substrate binding pocket [chemical binding]; other site 701177010974 chain length determination region; other site 701177010975 substrate-Mg2+ binding site; other site 701177010976 catalytic residues [active] 701177010977 aspartate-rich region 1; other site 701177010978 active site lid residues [active] 701177010979 aspartate-rich region 2; other site 701177010980 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 701177010981 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 701177010982 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 701177010983 hinge; other site 701177010984 active site 701177010985 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 701177010986 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 701177010987 anti sigma factor interaction site; other site 701177010988 regulatory phosphorylation site [posttranslational modification]; other site 701177010989 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 701177010990 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 701177010991 mce related protein; Region: MCE; pfam02470 701177010992 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 701177010993 conserved hypothetical integral membrane protein; Region: TIGR00056 701177010994 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 701177010995 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 701177010996 Walker A/P-loop; other site 701177010997 ATP binding site [chemical binding]; other site 701177010998 Q-loop/lid; other site 701177010999 ABC transporter signature motif; other site 701177011000 Walker B; other site 701177011001 D-loop; other site 701177011002 H-loop/switch region; other site 701177011003 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 701177011004 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 701177011005 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 701177011006 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 701177011007 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 701177011008 putative active site [active] 701177011009 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 701177011010 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 701177011011 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 701177011012 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 701177011013 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 701177011014 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 701177011015 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 701177011016 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 701177011017 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 701177011018 Walker A/P-loop; other site 701177011019 ATP binding site [chemical binding]; other site 701177011020 Q-loop/lid; other site 701177011021 ABC transporter signature motif; other site 701177011022 Walker B; other site 701177011023 D-loop; other site 701177011024 H-loop/switch region; other site 701177011025 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 701177011026 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 701177011027 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 701177011028 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 701177011029 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 701177011030 30S subunit binding site; other site 701177011031 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 701177011032 active site 701177011033 phosphorylation site [posttranslational modification] 701177011034 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 701177011035 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 701177011036 dimerization domain swap beta strand [polypeptide binding]; other site 701177011037 regulatory protein interface [polypeptide binding]; other site 701177011038 active site 701177011039 regulatory phosphorylation site [posttranslational modification]; other site 701177011040 hypothetical protein; Provisional; Region: PRK10345 701177011041 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 701177011042 Transglycosylase; Region: Transgly; cl17702 701177011043 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 701177011044 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 701177011045 conserved cys residue [active] 701177011046 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 701177011047 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 701177011048 putative active site [active] 701177011049 heme pocket [chemical binding]; other site 701177011050 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 701177011051 dimer interface [polypeptide binding]; other site 701177011052 phosphorylation site [posttranslational modification] 701177011053 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 701177011054 ATP binding site [chemical binding]; other site 701177011055 Mg2+ binding site [ion binding]; other site 701177011056 G-X-G motif; other site 701177011057 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 701177011058 active site 701177011059 phosphorylation site [posttranslational modification] 701177011060 intermolecular recognition site; other site 701177011061 dimerization interface [polypeptide binding]; other site 701177011062 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 701177011063 putative binding surface; other site 701177011064 active site 701177011065 radical SAM protein, TIGR01212 family; Region: TIGR01212 701177011066 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 701177011067 FeS/SAM binding site; other site 701177011068 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 701177011069 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 701177011070 active site 701177011071 dimer interface [polypeptide binding]; other site 701177011072 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 701177011073 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 701177011074 active site 701177011075 FMN binding site [chemical binding]; other site 701177011076 substrate binding site [chemical binding]; other site 701177011077 3Fe-4S cluster binding site [ion binding]; other site 701177011078 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 701177011079 domain interface; other site 701177011080 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 701177011081 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 701177011082 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 701177011083 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 701177011084 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 701177011085 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 701177011086 N-acetylmannosamine kinase; Provisional; Region: PRK05082 701177011087 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 701177011088 nucleotide binding site [chemical binding]; other site 701177011089 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 701177011090 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 701177011091 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 701177011092 putative active site cavity [active] 701177011093 putative sialic acid transporter; Provisional; Region: PRK03893 701177011094 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177011095 putative substrate translocation pore; other site 701177011096 N-acetylneuraminate lyase; Region: nanA; TIGR00683 701177011097 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 701177011098 inhibitor site; inhibition site 701177011099 active site 701177011100 dimer interface [polypeptide binding]; other site 701177011101 catalytic residue [active] 701177011102 transcriptional regulator NanR; Provisional; Region: PRK03837 701177011103 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 701177011104 DNA-binding site [nucleotide binding]; DNA binding site 701177011105 FCD domain; Region: FCD; pfam07729 701177011106 putative cryptic C4-dicarboxylate transporter DcuD; Provisional; Region: PRK09804 701177011107 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 701177011108 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 701177011109 stringent starvation protein A; Provisional; Region: sspA; PRK09481 701177011110 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 701177011111 C-terminal domain interface [polypeptide binding]; other site 701177011112 putative GSH binding site (G-site) [chemical binding]; other site 701177011113 dimer interface [polypeptide binding]; other site 701177011114 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 701177011115 dimer interface [polypeptide binding]; other site 701177011116 N-terminal domain interface [polypeptide binding]; other site 701177011117 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 701177011118 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 701177011119 23S rRNA interface [nucleotide binding]; other site 701177011120 L3 interface [polypeptide binding]; other site 701177011121 Predicted ATPase [General function prediction only]; Region: COG1485 701177011122 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 701177011123 hypothetical protein; Provisional; Region: PRK11677 701177011124 serine endoprotease; Provisional; Region: PRK10139 701177011125 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 701177011126 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 701177011127 protein binding site [polypeptide binding]; other site 701177011128 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 701177011129 serine endoprotease; Provisional; Region: PRK10898 701177011130 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 701177011131 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 701177011132 malate dehydrogenase; Provisional; Region: PRK05086 701177011133 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 701177011134 NAD binding site [chemical binding]; other site 701177011135 dimerization interface [polypeptide binding]; other site 701177011136 Substrate binding site [chemical binding]; other site 701177011137 arginine repressor; Provisional; Region: PRK05066 701177011138 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 701177011139 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 701177011140 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 701177011141 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 701177011142 RNAase interaction site [polypeptide binding]; other site 701177011143 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 701177011144 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 701177011145 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 701177011146 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 701177011147 HlyD family secretion protein; Region: HlyD_3; pfam13437 701177011148 efflux system membrane protein; Provisional; Region: PRK11594 701177011149 transcriptional regulator; Provisional; Region: PRK10632 701177011150 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 701177011151 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 701177011152 putative effector binding pocket; other site 701177011153 dimerization interface [polypeptide binding]; other site 701177011154 protease TldD; Provisional; Region: tldD; PRK10735 701177011155 hypothetical protein; Provisional; Region: PRK10899 701177011156 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 701177011157 ribonuclease G; Provisional; Region: PRK11712 701177011158 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 701177011159 homodimer interface [polypeptide binding]; other site 701177011160 oligonucleotide binding site [chemical binding]; other site 701177011161 Maf-like protein; Region: Maf; pfam02545 701177011162 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 701177011163 active site 701177011164 dimer interface [polypeptide binding]; other site 701177011165 rod shape-determining protein MreD; Provisional; Region: PRK11060 701177011166 rod shape-determining protein MreC; Region: mreC; TIGR00219 701177011167 rod shape-determining protein MreC; Region: MreC; pfam04085 701177011168 rod shape-determining protein MreB; Provisional; Region: PRK13927 701177011169 MreB and similar proteins; Region: MreB_like; cd10225 701177011170 nucleotide binding site [chemical binding]; other site 701177011171 Mg binding site [ion binding]; other site 701177011172 putative protofilament interaction site [polypeptide binding]; other site 701177011173 RodZ interaction site [polypeptide binding]; other site 701177011174 regulatory protein CsrD; Provisional; Region: PRK11059 701177011175 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 701177011176 metal binding site [ion binding]; metal-binding site 701177011177 active site 701177011178 I-site; other site 701177011179 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 701177011180 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 701177011181 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 701177011182 NADP binding site [chemical binding]; other site 701177011183 dimer interface [polypeptide binding]; other site 701177011184 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 701177011185 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 701177011186 carboxyltransferase (CT) interaction site; other site 701177011187 biotinylation site [posttranslational modification]; other site 701177011188 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 701177011189 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 701177011190 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 701177011191 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 701177011192 hypothetical protein; Provisional; Region: PRK10633 701177011193 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 701177011194 Na binding site [ion binding]; other site 701177011195 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 701177011196 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 701177011197 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 701177011198 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 701177011199 FMN binding site [chemical binding]; other site 701177011200 active site 701177011201 catalytic residues [active] 701177011202 substrate binding site [chemical binding]; other site 701177011203 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 701177011204 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 701177011205 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 701177011206 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 701177011207 DNA methylase; Region: N6_N4_Mtase; pfam01555 701177011208 Protein of unknown function (DUF2556); Region: DUF2556; pfam10831 701177011209 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 701177011210 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 701177011211 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 701177011212 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 701177011213 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 701177011214 HlyD family secretion protein; Region: HlyD_3; pfam13437 701177011215 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 701177011216 Protein export membrane protein; Region: SecD_SecF; cl14618 701177011217 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 701177011218 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 701177011219 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 701177011220 substrate binding pocket [chemical binding]; other site 701177011221 membrane-bound complex binding site; other site 701177011222 hinge residues; other site 701177011223 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 701177011224 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 701177011225 conserved gate region; other site 701177011226 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 701177011227 dimer interface [polypeptide binding]; other site 701177011228 conserved gate region; other site 701177011229 putative PBP binding loops; other site 701177011230 ABC-ATPase subunit interface; other site 701177011231 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 701177011232 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 701177011233 Walker A/P-loop; other site 701177011234 ATP binding site [chemical binding]; other site 701177011235 Q-loop/lid; other site 701177011236 ABC transporter signature motif; other site 701177011237 Walker B; other site 701177011238 D-loop; other site 701177011239 H-loop/switch region; other site 701177011240 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 701177011241 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 701177011242 trimer interface [polypeptide binding]; other site 701177011243 putative metal binding site [ion binding]; other site 701177011244 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 701177011245 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 701177011246 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 701177011247 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 701177011248 shikimate binding site; other site 701177011249 NAD(P) binding site [chemical binding]; other site 701177011250 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 701177011251 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 701177011252 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 701177011253 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 701177011254 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 701177011255 hypothetical protein; Validated; Region: PRK03430 701177011256 hypothetical protein; Provisional; Region: PRK10736 701177011257 DNA protecting protein DprA; Region: dprA; TIGR00732 701177011258 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 701177011259 active site 701177011260 catalytic residues [active] 701177011261 metal binding site [ion binding]; metal-binding site 701177011262 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 701177011263 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 701177011264 putative active site [active] 701177011265 substrate binding site [chemical binding]; other site 701177011266 putative cosubstrate binding site; other site 701177011267 catalytic site [active] 701177011268 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 701177011269 substrate binding site [chemical binding]; other site 701177011270 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 701177011271 putative RNA binding site [nucleotide binding]; other site 701177011272 16S rRNA methyltransferase B; Provisional; Region: PRK10901 701177011273 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 701177011274 S-adenosylmethionine binding site [chemical binding]; other site 701177011275 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 701177011276 TrkA-N domain; Region: TrkA_N; pfam02254 701177011277 TrkA-C domain; Region: TrkA_C; pfam02080 701177011278 TrkA-N domain; Region: TrkA_N; pfam02254 701177011279 TrkA-C domain; Region: TrkA_C; pfam02080 701177011280 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 701177011281 Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741 701177011282 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 701177011283 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 701177011284 DNA binding residues [nucleotide binding] 701177011285 dimer interface [polypeptide binding]; other site 701177011286 metal binding site [ion binding]; metal-binding site 701177011287 hypothetical protein; Provisional; Region: PRK10203 701177011288 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 701177011289 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 701177011290 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 701177011291 alphaNTD homodimer interface [polypeptide binding]; other site 701177011292 alphaNTD - beta interaction site [polypeptide binding]; other site 701177011293 alphaNTD - beta' interaction site [polypeptide binding]; other site 701177011294 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 701177011295 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 701177011296 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 701177011297 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 701177011298 RNA binding surface [nucleotide binding]; other site 701177011299 30S ribosomal protein S11; Validated; Region: PRK05309 701177011300 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 701177011301 30S ribosomal protein S13; Region: bact_S13; TIGR03631 701177011302 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 701177011303 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 701177011304 SecY translocase; Region: SecY; pfam00344 701177011305 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 701177011306 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 701177011307 23S rRNA binding site [nucleotide binding]; other site 701177011308 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 701177011309 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 701177011310 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 701177011311 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 701177011312 23S rRNA interface [nucleotide binding]; other site 701177011313 5S rRNA interface [nucleotide binding]; other site 701177011314 L27 interface [polypeptide binding]; other site 701177011315 L5 interface [polypeptide binding]; other site 701177011316 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 701177011317 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 701177011318 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 701177011319 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 701177011320 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 701177011321 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 701177011322 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 701177011323 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 701177011324 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 701177011325 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 701177011326 RNA binding site [nucleotide binding]; other site 701177011327 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 701177011328 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 701177011329 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 701177011330 23S rRNA interface [nucleotide binding]; other site 701177011331 putative translocon interaction site; other site 701177011332 signal recognition particle (SRP54) interaction site; other site 701177011333 L23 interface [polypeptide binding]; other site 701177011334 trigger factor interaction site; other site 701177011335 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 701177011336 23S rRNA interface [nucleotide binding]; other site 701177011337 5S rRNA interface [nucleotide binding]; other site 701177011338 putative antibiotic binding site [chemical binding]; other site 701177011339 L25 interface [polypeptide binding]; other site 701177011340 L27 interface [polypeptide binding]; other site 701177011341 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 701177011342 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 701177011343 G-X-X-G motif; other site 701177011344 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 701177011345 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 701177011346 protein-rRNA interface [nucleotide binding]; other site 701177011347 putative translocon binding site; other site 701177011348 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 701177011349 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 701177011350 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 701177011351 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 701177011352 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 701177011353 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 701177011354 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 701177011355 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 701177011356 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 701177011357 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 701177011358 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 701177011359 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 701177011360 heme binding site [chemical binding]; other site 701177011361 ferroxidase pore; other site 701177011362 ferroxidase diiron center [ion binding]; other site 701177011363 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 701177011364 elongation factor Tu; Reviewed; Region: PRK00049 701177011365 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 701177011366 G1 box; other site 701177011367 GEF interaction site [polypeptide binding]; other site 701177011368 GTP/Mg2+ binding site [chemical binding]; other site 701177011369 Switch I region; other site 701177011370 G2 box; other site 701177011371 G3 box; other site 701177011372 Switch II region; other site 701177011373 G4 box; other site 701177011374 G5 box; other site 701177011375 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 701177011376 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 701177011377 Antibiotic Binding Site [chemical binding]; other site 701177011378 elongation factor G; Reviewed; Region: PRK00007 701177011379 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 701177011380 G1 box; other site 701177011381 putative GEF interaction site [polypeptide binding]; other site 701177011382 GTP/Mg2+ binding site [chemical binding]; other site 701177011383 Switch I region; other site 701177011384 G2 box; other site 701177011385 G3 box; other site 701177011386 Switch II region; other site 701177011387 G4 box; other site 701177011388 G5 box; other site 701177011389 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 701177011390 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 701177011391 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 701177011392 30S ribosomal protein S7; Validated; Region: PRK05302 701177011393 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 701177011394 S17 interaction site [polypeptide binding]; other site 701177011395 S8 interaction site; other site 701177011396 16S rRNA interaction site [nucleotide binding]; other site 701177011397 streptomycin interaction site [chemical binding]; other site 701177011398 23S rRNA interaction site [nucleotide binding]; other site 701177011399 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 701177011400 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 701177011401 sulfur relay protein TusC; Validated; Region: PRK00211 701177011402 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 701177011403 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 701177011404 YheO-like PAS domain; Region: PAS_6; pfam08348 701177011405 HTH domain; Region: HTH_22; pfam13309 701177011406 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 701177011407 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 701177011408 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 701177011409 phi X174 lysis protein; Provisional; Region: PRK02793 701177011410 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 701177011411 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 701177011412 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 701177011413 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 701177011414 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 701177011415 TrkA-N domain; Region: TrkA_N; pfam02254 701177011416 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 701177011417 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 701177011418 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 701177011419 Walker A/P-loop; other site 701177011420 ATP binding site [chemical binding]; other site 701177011421 Q-loop/lid; other site 701177011422 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 701177011423 ABC transporter; Region: ABC_tran_2; pfam12848 701177011424 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 701177011425 putative hydrolase; Provisional; Region: PRK10985 701177011426 hypothetical protein; Provisional; Region: PRK04966 701177011427 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 701177011428 active site 701177011429 hypothetical protein; Provisional; Region: PRK10738 701177011430 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 701177011431 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 701177011432 ligand binding site [chemical binding]; other site 701177011433 flexible hinge region; other site 701177011434 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 701177011435 putative switch regulator; other site 701177011436 non-specific DNA interactions [nucleotide binding]; other site 701177011437 DNA binding site [nucleotide binding] 701177011438 sequence specific DNA binding site [nucleotide binding]; other site 701177011439 putative cAMP binding site [chemical binding]; other site 701177011440 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 701177011441 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 701177011442 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 701177011443 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 701177011444 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 701177011445 inhibitor-cofactor binding pocket; inhibition site 701177011446 pyridoxal 5'-phosphate binding site [chemical binding]; other site 701177011447 catalytic residue [active] 701177011448 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 701177011449 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 701177011450 glutamine binding [chemical binding]; other site 701177011451 catalytic triad [active] 701177011452 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 701177011453 cell filamentation protein Fic; Provisional; Region: PRK10347 701177011454 hypothetical protein; Provisional; Region: PRK10204 701177011455 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 701177011456 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 701177011457 substrate binding site [chemical binding]; other site 701177011458 putative transporter; Provisional; Region: PRK03699 701177011459 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177011460 putative substrate translocation pore; other site 701177011461 nitrite reductase subunit NirD; Provisional; Region: PRK14989 701177011462 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 701177011463 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 701177011464 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 701177011465 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 701177011466 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 701177011467 nitrite transporter NirC; Provisional; Region: PRK11562 701177011468 siroheme synthase; Provisional; Region: cysG; PRK10637 701177011469 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 701177011470 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 701177011471 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 701177011472 active site 701177011473 SAM binding site [chemical binding]; other site 701177011474 homodimer interface [polypeptide binding]; other site 701177011475 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 701177011476 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 701177011477 hypothetical protein; Provisional; Region: PHA02764 701177011478 fructoselysine-6-P-deglycase; Provisional; Region: frlB; PRK11382 701177011479 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 701177011480 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 701177011481 dimer interface [polypeptide binding]; other site 701177011482 active site 701177011483 fructoselysine 3-epimerase; Provisional; Region: PRK09856 701177011484 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 701177011485 AP (apurinic/apyrimidinic) site pocket; other site 701177011486 DNA interaction; other site 701177011487 Metal-binding active site; metal-binding site 701177011488 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 701177011489 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 701177011490 DNA-binding site [nucleotide binding]; DNA binding site 701177011491 UTRA domain; Region: UTRA; pfam07702 701177011492 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 701177011493 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 701177011494 active site 701177011495 HIGH motif; other site 701177011496 dimer interface [polypeptide binding]; other site 701177011497 KMSKS motif; other site 701177011498 phosphoglycolate phosphatase; Provisional; Region: PRK13222 701177011499 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 701177011500 motif II; other site 701177011501 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 701177011502 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 701177011503 substrate binding site [chemical binding]; other site 701177011504 hexamer interface [polypeptide binding]; other site 701177011505 metal binding site [ion binding]; metal-binding site 701177011506 DNA adenine methylase; Provisional; Region: PRK10904 701177011507 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 701177011508 cell division protein DamX; Validated; Region: PRK10905 701177011509 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 701177011510 active site 701177011511 dimer interface [polypeptide binding]; other site 701177011512 metal binding site [ion binding]; metal-binding site 701177011513 shikimate kinase; Reviewed; Region: aroK; PRK00131 701177011514 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 701177011515 ADP binding site [chemical binding]; other site 701177011516 magnesium binding site [ion binding]; other site 701177011517 putative shikimate binding site; other site 701177011518 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 701177011519 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 701177011520 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 701177011521 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 701177011522 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 701177011523 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 701177011524 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 701177011525 Transglycosylase; Region: Transgly; pfam00912 701177011526 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 701177011527 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 701177011528 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 701177011529 ADP-ribose binding site [chemical binding]; other site 701177011530 dimer interface [polypeptide binding]; other site 701177011531 active site 701177011532 nudix motif; other site 701177011533 metal binding site [ion binding]; metal-binding site 701177011534 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 701177011535 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 701177011536 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 701177011537 motif II; other site 701177011538 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 701177011539 RNA binding surface [nucleotide binding]; other site 701177011540 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 701177011541 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 701177011542 dimerization interface [polypeptide binding]; other site 701177011543 domain crossover interface; other site 701177011544 redox-dependent activation switch; other site 701177011545 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 701177011546 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 701177011547 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 701177011548 active site 701177011549 substrate-binding site [chemical binding]; other site 701177011550 metal-binding site [ion binding] 701177011551 ATP binding site [chemical binding]; other site 701177011552 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 701177011553 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 701177011554 dimerization interface [polypeptide binding]; other site 701177011555 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 701177011556 dimer interface [polypeptide binding]; other site 701177011557 phosphorylation site [posttranslational modification] 701177011558 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 701177011559 ATP binding site [chemical binding]; other site 701177011560 G-X-G motif; other site 701177011561 osmolarity response regulator; Provisional; Region: ompR; PRK09468 701177011562 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 701177011563 active site 701177011564 phosphorylation site [posttranslational modification] 701177011565 intermolecular recognition site; other site 701177011566 dimerization interface [polypeptide binding]; other site 701177011567 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 701177011568 DNA binding site [nucleotide binding] 701177011569 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 701177011570 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 701177011571 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 701177011572 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 701177011573 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 701177011574 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 701177011575 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 701177011576 RNA binding site [nucleotide binding]; other site 701177011577 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 701177011578 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 701177011579 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 701177011580 G1 box; other site 701177011581 GTP/Mg2+ binding site [chemical binding]; other site 701177011582 Switch I region; other site 701177011583 G2 box; other site 701177011584 G3 box; other site 701177011585 Switch II region; other site 701177011586 G4 box; other site 701177011587 G5 box; other site 701177011588 Nucleoside recognition; Region: Gate; pfam07670 701177011589 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 701177011590 Nucleoside recognition; Region: Gate; pfam07670 701177011591 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 701177011592 putative transposase; Provisional; Region: PRK09857 701177011593 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 701177011594 carboxylesterase BioH; Provisional; Region: PRK10349 701177011595 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 701177011596 DNA utilization protein GntX; Provisional; Region: PRK11595 701177011597 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 701177011598 active site 701177011599 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 701177011600 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 701177011601 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 701177011602 high-affinity gluconate transporter; Provisional; Region: PRK14984 701177011603 gluconate transporter; Region: gntP; TIGR00791 701177011604 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 701177011605 4-alpha-glucanotransferase; Region: malQ; TIGR00217 701177011606 maltodextrin phosphorylase; Provisional; Region: PRK14985 701177011607 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 701177011608 homodimer interface [polypeptide binding]; other site 701177011609 active site pocket [active] 701177011610 transcriptional regulator MalT; Provisional; Region: PRK04841 701177011611 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 701177011612 DNA binding residues [nucleotide binding] 701177011613 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 701177011614 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 701177011615 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 701177011616 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 701177011617 putative active site [active] 701177011618 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 701177011619 hypothetical protein; Reviewed; Region: PRK09588 701177011620 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 701177011621 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 701177011622 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 701177011623 Walker A motif; other site 701177011624 ATP binding site [chemical binding]; other site 701177011625 Walker B motif; other site 701177011626 arginine finger; other site 701177011627 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 701177011628 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 701177011629 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 701177011630 intramembrane serine protease GlpG; Provisional; Region: PRK10907 701177011631 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 701177011632 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 701177011633 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 701177011634 active site residue [active] 701177011635 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 701177011636 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 701177011637 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 701177011638 glycogen phosphorylase; Provisional; Region: PRK14986 701177011639 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 701177011640 homodimer interface [polypeptide binding]; other site 701177011641 active site pocket [active] 701177011642 glycogen synthase; Provisional; Region: glgA; PRK00654 701177011643 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 701177011644 ADP-binding pocket [chemical binding]; other site 701177011645 homodimer interface [polypeptide binding]; other site 701177011646 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 701177011647 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 701177011648 ligand binding site; other site 701177011649 oligomer interface; other site 701177011650 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 701177011651 sulfate 1 binding site; other site 701177011652 glycogen debranching enzyme; Provisional; Region: PRK03705 701177011653 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 701177011654 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 701177011655 active site 701177011656 catalytic site [active] 701177011657 glycogen branching enzyme; Provisional; Region: PRK05402 701177011658 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 701177011659 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 701177011660 active site 701177011661 catalytic site [active] 701177011662 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 701177011663 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 701177011664 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 701177011665 putative antibiotic transporter; Provisional; Region: PRK10739 701177011666 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 701177011667 DNA protecting protein DprA; Region: dprA; TIGR00732 701177011668 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 701177011669 non-specific DNA interactions [nucleotide binding]; other site 701177011670 DNA binding site [nucleotide binding] 701177011671 sequence specific DNA binding site [nucleotide binding]; other site 701177011672 putative cAMP binding site [chemical binding]; other site 701177011673 low affinity gluconate transporter; Provisional; Region: PRK10472 701177011674 gluconate transporter; Region: gntP; TIGR00791 701177011675 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 701177011676 ATP-binding site [chemical binding]; other site 701177011677 Gluconate-6-phosphate binding site [chemical binding]; other site 701177011678 Shikimate kinase; Region: SKI; pfam01202 701177011679 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 701177011680 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 701177011681 DNA binding site [nucleotide binding] 701177011682 domain linker motif; other site 701177011683 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 701177011684 putative ligand binding site [chemical binding]; other site 701177011685 putative dimerization interface [polypeptide binding]; other site 701177011686 Pirin-related protein [General function prediction only]; Region: COG1741 701177011687 Pirin; Region: Pirin; pfam02678 701177011688 putative oxidoreductase; Provisional; Region: PRK10206 701177011689 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 701177011690 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 701177011691 putative acetyltransferase YhhY; Provisional; Region: PRK10140 701177011692 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 701177011693 Coenzyme A binding pocket [chemical binding]; other site 701177011694 Protein of unknown function (DUF4225); Region: DUF4225; pfam13988 701177011695 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 701177011696 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 701177011697 hypothetical protein; Provisional; Region: PRK10350 701177011698 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 701177011699 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 701177011700 putative active site [active] 701177011701 catalytic site [active] 701177011702 putative metal binding site [ion binding]; other site 701177011703 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 701177011704 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 701177011705 Walker A/P-loop; other site 701177011706 ATP binding site [chemical binding]; other site 701177011707 Q-loop/lid; other site 701177011708 ABC transporter signature motif; other site 701177011709 Walker B; other site 701177011710 D-loop; other site 701177011711 H-loop/switch region; other site 701177011712 TOBE domain; Region: TOBE_2; pfam08402 701177011713 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 701177011714 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 701177011715 dimer interface [polypeptide binding]; other site 701177011716 conserved gate region; other site 701177011717 putative PBP binding loops; other site 701177011718 ABC-ATPase subunit interface; other site 701177011719 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 701177011720 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 701177011721 dimer interface [polypeptide binding]; other site 701177011722 conserved gate region; other site 701177011723 putative PBP binding loops; other site 701177011724 ABC-ATPase subunit interface; other site 701177011725 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 701177011726 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 701177011727 Uncharacterized protein conserved in bacteria containing a divergent form of TPR repeats [Function unknown]; Region: COG4700 701177011728 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 701177011729 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 701177011730 binding surface 701177011731 TPR motif; other site 701177011732 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 701177011733 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 701177011734 Walker A/P-loop; other site 701177011735 ATP binding site [chemical binding]; other site 701177011736 Q-loop/lid; other site 701177011737 ABC transporter signature motif; other site 701177011738 Walker B; other site 701177011739 D-loop; other site 701177011740 H-loop/switch region; other site 701177011741 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 701177011742 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 701177011743 Walker A/P-loop; other site 701177011744 ATP binding site [chemical binding]; other site 701177011745 Q-loop/lid; other site 701177011746 ABC transporter signature motif; other site 701177011747 Walker B; other site 701177011748 D-loop; other site 701177011749 H-loop/switch region; other site 701177011750 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 701177011751 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 701177011752 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 701177011753 TM-ABC transporter signature motif; other site 701177011754 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 701177011755 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 701177011756 TM-ABC transporter signature motif; other site 701177011757 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 701177011758 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 701177011759 dimerization interface [polypeptide binding]; other site 701177011760 ligand binding site [chemical binding]; other site 701177011761 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 701177011762 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 701177011763 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 701177011764 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 701177011765 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 701177011766 dimerization interface [polypeptide binding]; other site 701177011767 ligand binding site [chemical binding]; other site 701177011768 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 701177011769 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 701177011770 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 701177011771 DNA binding residues [nucleotide binding] 701177011772 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 701177011773 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 701177011774 cell division protein FtsE; Provisional; Region: PRK10908 701177011775 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 701177011776 Walker A/P-loop; other site 701177011777 ATP binding site [chemical binding]; other site 701177011778 Q-loop/lid; other site 701177011779 ABC transporter signature motif; other site 701177011780 Walker B; other site 701177011781 D-loop; other site 701177011782 H-loop/switch region; other site 701177011783 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 701177011784 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 701177011785 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 701177011786 P loop; other site 701177011787 GTP binding site [chemical binding]; other site 701177011788 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 701177011789 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 701177011790 S-adenosylmethionine binding site [chemical binding]; other site 701177011791 hypothetical protein; Provisional; Region: PRK10910 701177011792 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 701177011793 Predicted membrane protein [Function unknown]; Region: COG3714 701177011794 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 701177011795 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 701177011796 metal-binding site [ion binding] 701177011797 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 701177011798 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 701177011799 CPxP motif; other site 701177011800 hypothetical protein; Provisional; Region: PRK11212 701177011801 hypothetical protein; Provisional; Region: PRK11615 701177011802 major facilitator superfamily transporter; Provisional; Region: PRK05122 701177011803 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177011804 putative substrate translocation pore; other site 701177011805 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 701177011806 Domain of unknown function DUF20; Region: UPF0118; pfam01594 701177011807 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 701177011808 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 701177011809 S-adenosylmethionine binding site [chemical binding]; other site 701177011810 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 701177011811 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 701177011812 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 701177011813 putative acyl-acceptor binding pocket; other site 701177011814 Phosphopantetheine attachment site; Region: PP-binding; cl09936 701177011815 acyl carrier protein; Provisional; Region: PRK05350 701177011816 Predicted membrane protein [Function unknown]; Region: COG4648 701177011817 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 701177011818 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 701177011819 acyl-activating enzyme (AAE) consensus motif; other site 701177011820 active site 701177011821 AMP binding site [chemical binding]; other site 701177011822 CoA binding site [chemical binding]; other site 701177011823 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases [Lipid metabolism]; Region: FabA; COG0764 701177011824 active site 2 [active] 701177011825 active site 1 [active] 701177011826 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 701177011827 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 701177011828 Ligand binding site; other site 701177011829 Putative Catalytic site; other site 701177011830 DXD motif; other site 701177011831 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 701177011832 putative acyl-acceptor binding pocket; other site 701177011833 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 701177011834 active site 701177011835 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 701177011836 Predicted exporter [General function prediction only]; Region: COG4258 701177011837 Protein of unknown function (DUF3261); Region: DUF3261; pfam11659 701177011838 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 701177011839 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 701177011840 dimer interface [polypeptide binding]; other site 701177011841 active site 701177011842 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 701177011843 putative active site 1 [active] 701177011844 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 701177011845 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 701177011846 NAD(P) binding site [chemical binding]; other site 701177011847 active site 701177011848 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 701177011849 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 701177011850 dimer interface [polypeptide binding]; other site 701177011851 active site 701177011852 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 701177011853 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 701177011854 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 701177011855 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 701177011856 substrate binding site [chemical binding]; other site 701177011857 nickel transporter permease NikB; Provisional; Region: PRK10352 701177011858 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 701177011859 dimer interface [polypeptide binding]; other site 701177011860 conserved gate region; other site 701177011861 putative PBP binding loops; other site 701177011862 ABC-ATPase subunit interface; other site 701177011863 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 701177011864 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 701177011865 dimer interface [polypeptide binding]; other site 701177011866 conserved gate region; other site 701177011867 putative PBP binding loops; other site 701177011868 ABC-ATPase subunit interface; other site 701177011869 nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418 701177011870 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 701177011871 Walker A/P-loop; other site 701177011872 ATP binding site [chemical binding]; other site 701177011873 Q-loop/lid; other site 701177011874 ABC transporter signature motif; other site 701177011875 Walker B; other site 701177011876 D-loop; other site 701177011877 H-loop/switch region; other site 701177011878 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 701177011879 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 701177011880 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 701177011881 Walker A/P-loop; other site 701177011882 ATP binding site [chemical binding]; other site 701177011883 Q-loop/lid; other site 701177011884 ABC transporter signature motif; other site 701177011885 Walker B; other site 701177011886 D-loop; other site 701177011887 H-loop/switch region; other site 701177011888 nickel responsive regulator; Provisional; Region: PRK02967 701177011889 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 701177011890 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 701177011891 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 701177011892 DNA-binding site [nucleotide binding]; DNA binding site 701177011893 UTRA domain; Region: UTRA; pfam07702 701177011894 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 701177011895 active site 701177011896 phosphorylation site [posttranslational modification] 701177011897 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 701177011898 active site 701177011899 P-loop; other site 701177011900 phosphorylation site [posttranslational modification] 701177011901 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 701177011902 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 701177011903 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 701177011904 uncharacterized subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_1; cd07774 701177011905 putative N- and C-terminal domain interface [polypeptide binding]; other site 701177011906 putative active site [active] 701177011907 putative MgATP binding site [chemical binding]; other site 701177011908 catalytic site [active] 701177011909 metal binding site [ion binding]; metal-binding site 701177011910 putative carbohydrate binding site [chemical binding]; other site 701177011911 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 701177011912 dimerization domain swap beta strand [polypeptide binding]; other site 701177011913 regulatory protein interface [polypeptide binding]; other site 701177011914 active site 701177011915 regulatory phosphorylation site [posttranslational modification]; other site 701177011916 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 701177011917 intersubunit interface [polypeptide binding]; other site 701177011918 active site 701177011919 zinc binding site [ion binding]; other site 701177011920 Na+ binding site [ion binding]; other site 701177011921 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 701177011922 HicB family; Region: HicB; pfam05534 701177011923 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 701177011924 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 701177011925 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 701177011926 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 701177011927 Walker A/P-loop; other site 701177011928 ATP binding site [chemical binding]; other site 701177011929 Q-loop/lid; other site 701177011930 ABC transporter signature motif; other site 701177011931 Walker B; other site 701177011932 D-loop; other site 701177011933 H-loop/switch region; other site 701177011934 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 701177011935 Walker A/P-loop; other site 701177011936 ATP binding site [chemical binding]; other site 701177011937 Q-loop/lid; other site 701177011938 ABC transporter signature motif; other site 701177011939 Walker B; other site 701177011940 D-loop; other site 701177011941 H-loop/switch region; other site 701177011942 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 701177011943 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 701177011944 HlyD family secretion protein; Region: HlyD; pfam00529 701177011945 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 701177011946 HlyD family secretion protein; Region: HlyD_3; pfam13437 701177011947 Domain of unknown function (DUF4049); Region: DUF4049; pfam13258 701177011948 Domain of unknown function (DUF4049); Region: DUF4049; pfam13258 701177011949 Protein of unknown function (DUF2776); Region: DUF2776; pfam10951 701177011950 Predicted flavoproteins [General function prediction only]; Region: COG2081 701177011951 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 701177011952 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 701177011953 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 701177011954 universal stress protein UspB; Provisional; Region: PRK04960 701177011955 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 701177011956 Ligand Binding Site [chemical binding]; other site 701177011957 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 701177011958 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177011959 POT family; Region: PTR2; pfam00854 701177011960 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 701177011961 S-adenosylmethionine binding site [chemical binding]; other site 701177011962 oligopeptidase A; Provisional; Region: PRK10911 701177011963 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 701177011964 active site 701177011965 Zn binding site [ion binding]; other site 701177011966 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 701177011967 glutathione reductase; Validated; Region: PRK06116 701177011968 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 701177011969 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 701177011970 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 701177011971 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 701177011972 dimerization interface [polypeptide binding]; other site 701177011973 putative DNA binding site [nucleotide binding]; other site 701177011974 putative Zn2+ binding site [ion binding]; other site 701177011975 arsenical pump membrane protein; Provisional; Region: PRK15445 701177011976 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 701177011977 transmembrane helices; other site 701177011978 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 701177011979 ArsC family; Region: ArsC; pfam03960 701177011980 catalytic residues [active] 701177011981 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 701177011982 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 701177011983 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 701177011984 DNA binding residues [nucleotide binding] 701177011985 dimerization interface [polypeptide binding]; other site 701177011986 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 701177011987 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 701177011988 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 701177011989 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 701177011990 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 701177011991 N-terminal plug; other site 701177011992 ligand-binding site [chemical binding]; other site 701177011993 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 701177011994 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 701177011995 putative hemin binding site; other site 701177011996 coproporphyrinogen III oxidase; Provisional; Region: PRK09058 701177011997 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 701177011998 FeS/SAM binding site; other site 701177011999 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugX; COG3721 701177012000 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 701177012001 NADH(P)-binding; Region: NAD_binding_10; pfam13460 701177012002 NAD(P) binding site [chemical binding]; other site 701177012003 putative active site [active] 701177012004 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 701177012005 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 701177012006 ABC-ATPase subunit interface; other site 701177012007 dimer interface [polypeptide binding]; other site 701177012008 putative PBP binding regions; other site 701177012009 ABC-type hemin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG4559 701177012010 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 701177012011 Walker A/P-loop; other site 701177012012 ATP binding site [chemical binding]; other site 701177012013 Q-loop/lid; other site 701177012014 ABC transporter signature motif; other site 701177012015 Walker B; other site 701177012016 D-loop; other site 701177012017 H-loop/switch region; other site 701177012018 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 701177012019 MgtC family; Region: MgtC; pfam02308 701177012020 acid-resistance protein; Provisional; Region: hdeB; PRK11566 701177012021 acid-resistance protein; Provisional; Region: PRK10208 701177012022 acid-resistance membrane protein; Provisional; Region: PRK10209 701177012023 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 701177012024 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 701177012025 pyruvate kinase; Provisional; Region: PRK05826 701177012026 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 701177012027 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 701177012028 HlyD family secretion protein; Region: HlyD_3; pfam13437 701177012029 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 701177012030 Protein export membrane protein; Region: SecD_SecF; cl14618 701177012031 transcriptional regulator YdeO; Provisional; Region: PRK09940 701177012032 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 701177012033 DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978 701177012034 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 701177012035 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 701177012036 pyridoxal 5'-phosphate binding site [chemical binding]; other site 701177012037 catalytic residue [active] 701177012038 Haem-binding domain; Region: Haem_bd; pfam14376 701177012039 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 701177012040 trehalase; Provisional; Region: treF; PRK13270 701177012041 Trehalase; Region: Trehalase; pfam01204 701177012042 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 701177012043 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 701177012044 DNA binding residues [nucleotide binding] 701177012045 dimerization interface [polypeptide binding]; other site 701177012046 Transcriptional regulator [Transcription]; Region: LysR; COG0583 701177012047 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 701177012048 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 701177012049 putative effector binding pocket; other site 701177012050 putative dimerization interface [polypeptide binding]; other site 701177012051 inner membrane protein YhjD; Region: TIGR00766 701177012052 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177012053 metabolite-proton symporter; Region: 2A0106; TIGR00883 701177012054 putative substrate translocation pore; other site 701177012055 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 701177012056 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 701177012057 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 701177012058 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 701177012059 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 701177012060 substrate binding site [chemical binding]; other site 701177012061 ATP binding site [chemical binding]; other site 701177012062 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 701177012063 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 701177012064 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 701177012065 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 701177012066 putative diguanylate cyclase; Provisional; Region: PRK13561 701177012067 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 701177012068 metal binding site [ion binding]; metal-binding site 701177012069 active site 701177012070 I-site; other site 701177012071 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 701177012072 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 701177012073 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 701177012074 binding surface 701177012075 TPR motif; other site 701177012076 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 701177012077 endo-1,4-D-glucanase; Provisional; Region: PRK11097 701177012078 cellulose synthase regulator protein; Provisional; Region: PRK11114 701177012079 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 701177012080 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 701177012081 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 701177012082 DXD motif; other site 701177012083 PilZ domain; Region: PilZ; pfam07238 701177012084 cell division protein; Provisional; Region: PRK10037 701177012085 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 701177012086 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 701177012087 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 701177012088 celllulose biosynthesis operon protein BcsF/YhjT; Region: cellullose_BcsF; TIGR03493 701177012089 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 701177012090 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 701177012091 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 701177012092 serine transporter; Region: stp; TIGR00814 701177012093 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 701177012094 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 701177012095 Walker A/P-loop; other site 701177012096 ATP binding site [chemical binding]; other site 701177012097 Q-loop/lid; other site 701177012098 ABC transporter signature motif; other site 701177012099 Walker B; other site 701177012100 D-loop; other site 701177012101 H-loop/switch region; other site 701177012102 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 701177012103 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 701177012104 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 701177012105 Walker A/P-loop; other site 701177012106 ATP binding site [chemical binding]; other site 701177012107 Q-loop/lid; other site 701177012108 ABC transporter signature motif; other site 701177012109 Walker B; other site 701177012110 D-loop; other site 701177012111 H-loop/switch region; other site 701177012112 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 701177012113 dipeptide transporter; Provisional; Region: PRK10913 701177012114 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 701177012115 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 701177012116 dimer interface [polypeptide binding]; other site 701177012117 conserved gate region; other site 701177012118 putative PBP binding loops; other site 701177012119 ABC-ATPase subunit interface; other site 701177012120 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 701177012121 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 701177012122 dimer interface [polypeptide binding]; other site 701177012123 conserved gate region; other site 701177012124 putative PBP binding loops; other site 701177012125 ABC-ATPase subunit interface; other site 701177012126 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 701177012127 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 701177012128 peptide binding site [polypeptide binding]; other site 701177012129 phosphoethanolamine transferase; Provisional; Region: PRK11560 701177012130 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 701177012131 Sulfatase; Region: Sulfatase; pfam00884 701177012132 long polar fimbrial protein LpfE; Provisional; Region: PRK15205 701177012133 Fimbrial protein; Region: Fimbrial; cl01416 701177012134 long polar fimbrial outer membrane usher protein LpfC; Provisional; Region: PRK15207 701177012135 PapC N-terminal domain; Region: PapC_N; pfam13954 701177012136 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 701177012137 PapC C-terminal domain; Region: PapC_C; pfam13953 701177012138 long polar fimbrial chaperone LpfB; Provisional; Region: PRK15208 701177012139 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 701177012140 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 701177012141 long polar fimbrial protein LpfA; Provisional; Region: PRK15209 701177012142 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 701177012143 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177012144 putative substrate translocation pore; other site 701177012145 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 701177012146 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 701177012147 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 701177012148 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 701177012149 Coenzyme A binding pocket [chemical binding]; other site 701177012150 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 701177012151 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 701177012152 molybdopterin cofactor binding site [chemical binding]; other site 701177012153 substrate binding site [chemical binding]; other site 701177012154 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 701177012155 molybdopterin cofactor binding site; other site 701177012156 putative outer membrane lipoprotein; Provisional; Region: PRK10510 701177012157 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 701177012158 ligand binding site [chemical binding]; other site 701177012159 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 701177012160 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 701177012161 dimerization interface [polypeptide binding]; other site 701177012162 ligand binding site [chemical binding]; other site 701177012163 NADP binding site [chemical binding]; other site 701177012164 catalytic site [active] 701177012165 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 701177012166 Predicted transcriptional regulator [Transcription]; Region: COG2944 701177012167 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 701177012168 non-specific DNA binding site [nucleotide binding]; other site 701177012169 salt bridge; other site 701177012170 sequence-specific DNA binding site [nucleotide binding]; other site 701177012171 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 701177012172 DNA-binding site [nucleotide binding]; DNA binding site 701177012173 RNA-binding motif; other site 701177012174 small toxic polypeptide; Provisional; Region: PRK09759 701177012175 glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211 701177012176 DALR anticodon binding domain; Region: DALR_1; pfam05746 701177012177 anticodon binding site; other site 701177012178 tRNA binding surface [nucleotide binding]; other site 701177012179 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 701177012180 dimer interface [polypeptide binding]; other site 701177012181 motif 1; other site 701177012182 active site 701177012183 motif 2; other site 701177012184 motif 3; other site 701177012185 YsaB-like lipoprotein; Region: YsaB; pfam13983 701177012186 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 701177012187 Acyltransferase family; Region: Acyl_transf_3; pfam01757 701177012188 hypothetical protein; Provisional; Region: PRK11383 701177012189 yiaA/B two helix domain; Region: YiaAB; pfam05360 701177012190 yiaA/B two helix domain; Region: YiaAB; pfam05360 701177012191 hypothetical protein; Provisional; Region: PRK11403 701177012192 yiaA/B two helix domain; Region: YiaAB; pfam05360 701177012193 xylulokinase; Provisional; Region: PRK15027 701177012194 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 701177012195 N- and C-terminal domain interface [polypeptide binding]; other site 701177012196 active site 701177012197 MgATP binding site [chemical binding]; other site 701177012198 catalytic site [active] 701177012199 metal binding site [ion binding]; metal-binding site 701177012200 xylulose binding site [chemical binding]; other site 701177012201 homodimer interface [polypeptide binding]; other site 701177012202 xylose isomerase; Provisional; Region: PRK05474 701177012203 xylose isomerase; Region: xylose_isom_A; TIGR02630 701177012204 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 701177012205 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 701177012206 putative ligand binding site [chemical binding]; other site 701177012207 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 701177012208 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 701177012209 Walker A/P-loop; other site 701177012210 ATP binding site [chemical binding]; other site 701177012211 Q-loop/lid; other site 701177012212 ABC transporter signature motif; other site 701177012213 Walker B; other site 701177012214 D-loop; other site 701177012215 H-loop/switch region; other site 701177012216 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 701177012217 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 701177012218 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 701177012219 TM-ABC transporter signature motif; other site 701177012220 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 701177012221 putative dimerization interface [polypeptide binding]; other site 701177012222 Transcriptional regulators [Transcription]; Region: PurR; COG1609 701177012223 putative ligand binding site [chemical binding]; other site 701177012224 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 701177012225 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 701177012226 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 701177012227 hypothetical protein; Provisional; Region: PRK10356 701177012228 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 701177012229 alpha-amylase; Reviewed; Region: malS; PRK09505 701177012230 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 701177012231 active site 701177012232 catalytic site [active] 701177012233 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 701177012234 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 701177012235 pyridoxal 5'-phosphate binding site [chemical binding]; other site 701177012236 homodimer interface [polypeptide binding]; other site 701177012237 catalytic residue [active] 701177012238 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 701177012239 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 701177012240 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 701177012241 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 701177012242 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 701177012243 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 701177012244 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 701177012245 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 701177012246 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 701177012247 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 701177012248 Transcriptional regulator [Transcription]; Region: LysR; COG0583 701177012249 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 701177012250 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 701177012251 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 701177012252 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 701177012253 HlyD family secretion protein; Region: HlyD_3; pfam13437 701177012254 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 701177012255 FlxA-like protein; Region: FlxA; pfam14282 701177012256 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 701177012257 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 701177012258 NAD(P) binding site [chemical binding]; other site 701177012259 catalytic residues [active] 701177012260 Fic family protein [Function unknown]; Region: COG3177 701177012261 Fic/DOC family; Region: Fic; pfam02661 701177012262 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 701177012263 putative alcohol dehydrogenase; Provisional; Region: PRK09860 701177012264 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 701177012265 dimer interface [polypeptide binding]; other site 701177012266 active site 701177012267 metal binding site [ion binding]; metal-binding site 701177012268 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 701177012269 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 701177012270 G1 box; other site 701177012271 putative GEF interaction site [polypeptide binding]; other site 701177012272 GTP/Mg2+ binding site [chemical binding]; other site 701177012273 Switch I region; other site 701177012274 G2 box; other site 701177012275 G3 box; other site 701177012276 Switch II region; other site 701177012277 G4 box; other site 701177012278 G5 box; other site 701177012279 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 701177012280 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 701177012281 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 701177012282 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 701177012283 selenocysteine synthase; Provisional; Region: PRK04311 701177012284 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 701177012285 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 701177012286 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 701177012287 catalytic residue [active] 701177012288 putative glutathione S-transferase; Provisional; Region: PRK10357 701177012289 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 701177012290 putative C-terminal domain interface [polypeptide binding]; other site 701177012291 putative GSH binding site (G-site) [chemical binding]; other site 701177012292 putative dimer interface [polypeptide binding]; other site 701177012293 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 701177012294 dimer interface [polypeptide binding]; other site 701177012295 N-terminal domain interface [polypeptide binding]; other site 701177012296 putative substrate binding pocket (H-site) [chemical binding]; other site 701177012297 PAAR motif; Region: PAAR_motif; cl15808 701177012298 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 701177012299 RHS Repeat; Region: RHS_repeat; pfam05593 701177012300 RHS Repeat; Region: RHS_repeat; pfam05593 701177012301 RHS Repeat; Region: RHS_repeat; pfam05593 701177012302 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 701177012303 RHS Repeat; Region: RHS_repeat; pfam05593 701177012304 RHS Repeat; Region: RHS_repeat; pfam05593 701177012305 RHS protein; Region: RHS; pfam03527 701177012306 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 701177012307 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 701177012308 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 701177012309 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 701177012310 HlyD family secretion protein; Region: HlyD_3; pfam13437 701177012311 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 701177012312 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 701177012313 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 701177012314 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 701177012315 active site 701177012316 P-loop; other site 701177012317 phosphorylation site [posttranslational modification] 701177012318 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 701177012319 active site 701177012320 phosphorylation site [posttranslational modification] 701177012321 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 701177012322 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 701177012323 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 701177012324 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 701177012325 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 701177012326 hypothetical protein; Provisional; Region: PRK11020 701177012327 Protein of unknown function (DUF3251); Region: DUF3251; cl08186 701177012328 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 701177012329 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 701177012330 trimer interface [polypeptide binding]; other site 701177012331 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 701177012332 trimer interface [polypeptide binding]; other site 701177012333 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 701177012334 trimer interface [polypeptide binding]; other site 701177012335 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 701177012336 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 701177012337 trimer interface [polypeptide binding]; other site 701177012338 Haemagglutinin; Region: HIM; pfam05662 701177012339 Haemagglutinin; Region: HIM; pfam05662 701177012340 YadA-like C-terminal region; Region: YadA; pfam03895 701177012341 L-lactate permease; Provisional; Region: PRK10420 701177012342 glycolate transporter; Provisional; Region: PRK09695 701177012343 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 701177012344 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 701177012345 DNA-binding site [nucleotide binding]; DNA binding site 701177012346 FCD domain; Region: FCD; pfam07729 701177012347 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 701177012348 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 701177012349 phosphate binding site [ion binding]; other site 701177012350 putative rRNA methylase; Provisional; Region: PRK10358 701177012351 serine acetyltransferase; Provisional; Region: cysE; PRK11132 701177012352 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 701177012353 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 701177012354 trimer interface [polypeptide binding]; other site 701177012355 active site 701177012356 substrate binding site [chemical binding]; other site 701177012357 CoA binding site [chemical binding]; other site 701177012358 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 701177012359 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 701177012360 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 701177012361 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 701177012362 SecA binding site; other site 701177012363 Preprotein binding site; other site 701177012364 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 701177012365 GSH binding site [chemical binding]; other site 701177012366 catalytic residues [active] 701177012367 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 701177012368 active site residue [active] 701177012369 phosphoglyceromutase; Provisional; Region: PRK05434 701177012370 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 701177012371 AmiB activator; Provisional; Region: PRK11637 701177012372 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 701177012373 Peptidase family M23; Region: Peptidase_M23; pfam01551 701177012374 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 701177012375 NodB motif; other site 701177012376 putative active site [active] 701177012377 putative catalytic site [active] 701177012378 Zn binding site [ion binding]; other site 701177012379 putative glycosyl transferase; Provisional; Region: PRK10073 701177012380 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 701177012381 active site 701177012382 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 701177012383 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 701177012384 NAD(P) binding site [chemical binding]; other site 701177012385 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 701177012386 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 701177012387 substrate-cofactor binding pocket; other site 701177012388 pyridoxal 5'-phosphate binding site [chemical binding]; other site 701177012389 catalytic residue [active] 701177012390 hypothetical protein; Provisional; Region: PRK11346 701177012391 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 701177012392 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 701177012393 NADP binding site [chemical binding]; other site 701177012394 homopentamer interface [polypeptide binding]; other site 701177012395 substrate binding site [chemical binding]; other site 701177012396 active site 701177012397 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 701177012398 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 701177012399 putative active site [active] 701177012400 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 701177012401 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 701177012402 putative active site [active] 701177012403 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 701177012404 O-antigen ligase RfaL; Provisional; Region: PRK15487 701177012405 lipopolysaccharide 1,2-N-acetylglucosaminetransferase; Provisional; Region: PRK15484 701177012406 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 701177012407 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 701177012408 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 701177012409 Ligand binding site; other site 701177012410 metal-binding site 701177012411 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 701177012412 Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; cl17526 701177012413 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 701177012414 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 701177012415 Ligand binding site; other site 701177012416 metal-binding site 701177012417 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 701177012418 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 701177012419 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 701177012420 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 701177012421 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 701177012422 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 701177012423 putative active site [active] 701177012424 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 701177012425 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 701177012426 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 701177012427 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 701177012428 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 701177012429 active site 701177012430 (T/H)XGH motif; other site 701177012431 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 701177012432 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 701177012433 DNA binding site [nucleotide binding] 701177012434 catalytic residue [active] 701177012435 H2TH interface [polypeptide binding]; other site 701177012436 putative catalytic residues [active] 701177012437 turnover-facilitating residue; other site 701177012438 intercalation triad [nucleotide binding]; other site 701177012439 8OG recognition residue [nucleotide binding]; other site 701177012440 putative reading head residues; other site 701177012441 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 701177012442 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 701177012443 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 701177012444 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 701177012445 hypothetical protein; Reviewed; Region: PRK00024 701177012446 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 701177012447 MPN+ (JAMM) motif; other site 701177012448 Zinc-binding site [ion binding]; other site 701177012449 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 701177012450 Flavoprotein; Region: Flavoprotein; pfam02441 701177012451 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 701177012452 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 701177012453 trimer interface [polypeptide binding]; other site 701177012454 active site 701177012455 division inhibitor protein; Provisional; Region: slmA; PRK09480 701177012456 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 701177012457 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 701177012458 active site 701177012459 ribonuclease PH; Reviewed; Region: rph; PRK00173 701177012460 Ribonuclease PH; Region: RNase_PH_bact; cd11362 701177012461 hexamer interface [polypeptide binding]; other site 701177012462 active site 701177012463 hypothetical protein; Provisional; Region: PRK11820 701177012464 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 701177012465 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 701177012466 DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525 701177012467 BRO family, N-terminal domain; Region: Bro-N; pfam02498 701177012468 Predicted membrane protein [Function unknown]; Region: COG2860 701177012469 UPF0126 domain; Region: UPF0126; pfam03458 701177012470 UPF0126 domain; Region: UPF0126; pfam03458 701177012471 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 701177012472 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 701177012473 nucleotide binding pocket [chemical binding]; other site 701177012474 K-X-D-G motif; other site 701177012475 catalytic site [active] 701177012476 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 701177012477 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 701177012478 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 701177012479 catalytic site [active] 701177012480 G-X2-G-X-G-K; other site 701177012481 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 701177012482 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 701177012483 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 701177012484 Zn2+ binding site [ion binding]; other site 701177012485 Mg2+ binding site [ion binding]; other site 701177012486 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 701177012487 synthetase active site [active] 701177012488 NTP binding site [chemical binding]; other site 701177012489 metal binding site [ion binding]; metal-binding site 701177012490 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 701177012491 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 701177012492 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 701177012493 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 701177012494 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 701177012495 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 701177012496 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 701177012497 generic binding surface II; other site 701177012498 ssDNA binding site; other site 701177012499 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 701177012500 ATP binding site [chemical binding]; other site 701177012501 putative Mg++ binding site [ion binding]; other site 701177012502 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 701177012503 nucleotide binding region [chemical binding]; other site 701177012504 ATP-binding site [chemical binding]; other site 701177012505 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 701177012506 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 701177012507 AsmA family; Region: AsmA; pfam05170 701177012508 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 701177012509 putative alpha-glucosidase; Provisional; Region: PRK10658 701177012510 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 701177012511 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 701177012512 active site 701177012513 homotrimer interface [polypeptide binding]; other site 701177012514 catalytic site [active] 701177012515 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 701177012516 putative transporter; Provisional; Region: PRK11462 701177012517 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 701177012518 integrase; Provisional; Region: PRK09692 701177012519 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 701177012520 active site 701177012521 Int/Topo IB signature motif; other site 701177012522 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 701177012523 Transposase; Region: HTH_Tnp_1; cl17663 701177012524 Integrase core domain; Region: rve; pfam00665 701177012525 DDE domain; Region: DDE_Tnp_IS240; pfam13610 701177012526 Integrase core domain; Region: rve_3; pfam13683 701177012527 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 701177012528 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 701177012529 Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117 701177012530 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14951 701177012531 type III secretion system protein, SsaH family; Region: type_III_ssaH; TIGR02498 701177012532 type III secretion apparatus needle protein; Region: III_needle; TIGR02105 701177012533 pathogenicity island 2 effector protein SseE; Provisional; Region: PRK15360 701177012534 Enterobacterial EspB protein; Region: EspB; pfam05802 701177012535 Uncharacterized conserved protein [Function unknown]; Region: COG5613 701177012536 EspA-like secreted protein; Region: EspA; pfam03433 701177012537 HrpJ-like domain; Region: HrpJ; pfam07201 701177012538 type III secretion effector delivery regulator, TyeA family; Region: type_III_tyeA; TIGR02511 701177012539 type III secretion system protein SsaD; Provisional; Region: PRK15367 701177012540 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 701177012541 LysM domain; Region: LysM; pfam01476 701177012542 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 701177012543 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 701177012544 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 701177012545 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 701177012546 Intimin C-type lectin domain; Region: Intimin_C; pfam07979 701177012547 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 701177012548 Translocated intimin receptor (Tir) N-terminus; Region: Tir_receptor_N; pfam07490 701177012549 Translocated intimin receptor (Tir) intimin-binding domain; Region: Tir_receptor_M; pfam03549 701177012550 Translocated intimin receptor (Tir) C-terminus; Region: Tir_receptor_C; pfam07489 701177012551 IpaB/EvcA family; Region: IpaB_EvcA; pfam03278 701177012552 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 701177012553 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 701177012554 Protein of unknown function (DUF1106); Region: DUF1106; pfam06523 701177012555 type III secretion apparatus H+-transporting two-sector ATPase; Region: III_secr_ATP; TIGR02546 701177012556 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 701177012557 Walker A motif/ATP binding site; other site 701177012558 Walker B motif; other site 701177012559 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 701177012560 FHIPEP family; Region: FHIPEP; pfam00771 701177012561 SepZ; Region: SepZ; pfam06066 701177012562 Type III secretory pathway, lipoprotein EscJ [Intracellular trafficking and secretion]; Region: EscJ; COG4669 701177012563 outer membrane secretin SsaC; Provisional; Region: PRK15346 701177012564 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 701177012565 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 701177012566 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 701177012567 Tetratricopeptide repeat; Region: TPR_3; pfam07720 701177012568 Protein of unknown function (DUF1401); Region: DUF1401; pfam07180 701177012569 negative regulator GrlR; Provisional; Region: PRK14051 701177012570 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 701177012571 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 701177012572 N-acetyl-D-glucosamine binding site [chemical binding]; other site 701177012573 catalytic residue [active] 701177012574 secretion system apparatus protein SsaU; Reviewed; Region: PRK12721 701177012575 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 701177012576 type III secretion protein SpaR/YscT/HrcT; Region: fliR_like_III; TIGR01401 701177012577 Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794 701177012578 Type III secretory pathway, component EscR [Intracellular trafficking and secretion]; Region: EscR; COG4790 701177012579 Type III secretion system subunit; Region: T3SS_LEE_assoc; pfam13327 701177012580 Type III secretion system filament chaperone CesA; Region: CesA; pfam11439 701177012581 type III secretion system protein, YseE family; Region: type_III_yscE; TIGR02501 701177012582 DNA-binding protein H-NS [General function prediction only]; Region: Hns; COG2916 701177012583 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 701177012584 EspG protein; Region: EspG; pfam06872 701177012585 SdiA-regulated; Region: SdiA-regulated; cd09971 701177012586 SdiA-regulated; Region: SdiA-regulated; pfam06977 701177012587 putative active site [active] 701177012588 EamA-like transporter family; Region: EamA; pfam00892 701177012589 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 701177012590 EamA-like transporter family; Region: EamA; pfam00892 701177012591 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 701177012592 lipoprotein, YaeC family; Region: TIGR00363 701177012593 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 701177012594 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177012595 putative substrate translocation pore; other site 701177012596 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4737 701177012597 Predicted transcriptional regulator [Transcription]; Region: COG2944 701177012598 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 701177012599 non-specific DNA binding site [nucleotide binding]; other site 701177012600 salt bridge; other site 701177012601 sequence-specific DNA binding site [nucleotide binding]; other site 701177012602 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 701177012603 cryptic adenine deaminase; Provisional; Region: PRK10027 701177012604 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 701177012605 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 701177012606 active site 701177012607 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 701177012608 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 701177012609 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177012610 putative substrate translocation pore; other site 701177012611 regulatory protein UhpC; Provisional; Region: PRK11663 701177012612 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177012613 putative substrate translocation pore; other site 701177012614 sensory histidine kinase UhpB; Provisional; Region: PRK11644 701177012615 MASE1; Region: MASE1; pfam05231 701177012616 Histidine kinase; Region: HisKA_3; pfam07730 701177012617 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 701177012618 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 701177012619 active site 701177012620 phosphorylation site [posttranslational modification] 701177012621 intermolecular recognition site; other site 701177012622 dimerization interface [polypeptide binding]; other site 701177012623 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 701177012624 DNA binding residues [nucleotide binding] 701177012625 dimerization interface [polypeptide binding]; other site 701177012626 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 701177012627 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 701177012628 putative valine binding site [chemical binding]; other site 701177012629 dimer interface [polypeptide binding]; other site 701177012630 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 701177012631 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 701177012632 PYR/PP interface [polypeptide binding]; other site 701177012633 dimer interface [polypeptide binding]; other site 701177012634 TPP binding site [chemical binding]; other site 701177012635 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 701177012636 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 701177012637 TPP-binding site [chemical binding]; other site 701177012638 dimer interface [polypeptide binding]; other site 701177012639 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 701177012640 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177012641 putative substrate translocation pore; other site 701177012642 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 701177012643 Domain of unknown function (DUF202); Region: DUF202; pfam02656 701177012644 Predicted membrane protein [Function unknown]; Region: COG2149 701177012645 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 701177012646 Sulfatase; Region: Sulfatase; pfam00884 701177012647 putative transporter; Provisional; Region: PRK10484 701177012648 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 701177012649 Na binding site [ion binding]; other site 701177012650 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 701177012651 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 701177012652 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 701177012653 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 701177012654 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 701177012655 NAD binding site [chemical binding]; other site 701177012656 sugar binding site [chemical binding]; other site 701177012657 divalent metal binding site [ion binding]; other site 701177012658 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 701177012659 dimer interface [polypeptide binding]; other site 701177012660 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 701177012661 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 701177012662 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 701177012663 active site turn [active] 701177012664 phosphorylation site [posttranslational modification] 701177012665 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 701177012666 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 701177012667 DNA-binding site [nucleotide binding]; DNA binding site 701177012668 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 701177012669 putative transporter; Validated; Region: PRK03818 701177012670 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 701177012671 TrkA-C domain; Region: TrkA_C; pfam02080 701177012672 TrkA-C domain; Region: TrkA_C; pfam02080 701177012673 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 701177012674 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 701177012675 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 701177012676 putative dimer interface [polypeptide binding]; other site 701177012677 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 701177012678 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 701177012679 putative dimer interface [polypeptide binding]; other site 701177012680 hypothetical protein; Provisional; Region: PRK11616 701177012681 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 701177012682 putative oxidoreductase; Provisional; Region: PRK11445 701177012683 hypothetical protein; Provisional; Region: PRK07236 701177012684 hypothetical protein; Provisional; Region: PRK10215 701177012685 sugar phosphate phosphatase; Provisional; Region: PRK10513 701177012686 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 701177012687 active site 701177012688 motif I; other site 701177012689 motif II; other site 701177012690 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 701177012691 hypothetical protein; Provisional; Region: PRK11426 701177012692 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 701177012693 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 701177012694 Mg2+ binding site [ion binding]; other site 701177012695 G-X-G motif; other site 701177012696 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 701177012697 anchoring element; other site 701177012698 dimer interface [polypeptide binding]; other site 701177012699 ATP binding site [chemical binding]; other site 701177012700 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 701177012701 active site 701177012702 putative metal-binding site [ion binding]; other site 701177012703 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 701177012704 recF protein; Region: recf; TIGR00611 701177012705 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 701177012706 Walker A/P-loop; other site 701177012707 ATP binding site [chemical binding]; other site 701177012708 Q-loop/lid; other site 701177012709 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 701177012710 ABC transporter signature motif; other site 701177012711 Walker B; other site 701177012712 D-loop; other site 701177012713 H-loop/switch region; other site 701177012714 DNA polymerase III subunit beta; Validated; Region: PRK05643 701177012715 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 701177012716 putative DNA binding surface [nucleotide binding]; other site 701177012717 dimer interface [polypeptide binding]; other site 701177012718 beta-clamp/clamp loader binding surface; other site 701177012719 beta-clamp/translesion DNA polymerase binding surface; other site 701177012720 DnaA N-terminal domain; Region: DnaA_N; pfam11638 701177012721 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 701177012722 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 701177012723 Walker A motif; other site 701177012724 ATP binding site [chemical binding]; other site 701177012725 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 701177012726 Walker B motif; other site 701177012727 arginine finger; other site 701177012728 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 701177012729 DnaA box-binding interface [nucleotide binding]; other site 701177012730 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 701177012731 ribonuclease P; Reviewed; Region: rnpA; PRK01732 701177012732 membrane protein insertase; Provisional; Region: PRK01318 701177012733 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 701177012734 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 701177012735 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 701177012736 trmE is a tRNA modification GTPase; Region: trmE; cd04164 701177012737 G1 box; other site 701177012738 GTP/Mg2+ binding site [chemical binding]; other site 701177012739 Switch I region; other site 701177012740 G2 box; other site 701177012741 Switch II region; other site 701177012742 G3 box; other site 701177012743 G4 box; other site 701177012744 G5 box; other site 701177012745 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 701177012746 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 701177012747 Tryptophanese operon leader peptide; Region: Tna_leader; pfam08053 701177012748 tryptophanase, leader peptide-associated; Region: tnaA_trp_ase; TIGR02617 701177012749 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 701177012750 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 701177012751 catalytic residue [active] 701177012752 tryptophan permease TnaB; Provisional; Region: PRK09664 701177012753 aromatic amino acid transport protein; Region: araaP; TIGR00837 701177012754 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 701177012755 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177012756 putative substrate translocation pore; other site 701177012757 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 701177012758 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 701177012759 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 701177012760 substrate binding pocket [chemical binding]; other site 701177012761 dimerization interface [polypeptide binding]; other site 701177012762 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 701177012763 Predicted flavoprotein [General function prediction only]; Region: COG0431 701177012764 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 701177012765 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 701177012766 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 701177012767 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 701177012768 active site 701177012769 motif I; other site 701177012770 motif II; other site 701177012771 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 701177012772 transcriptional regulator PhoU; Provisional; Region: PRK11115 701177012773 PhoU domain; Region: PhoU; pfam01895 701177012774 PhoU domain; Region: PhoU; pfam01895 701177012775 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 701177012776 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 701177012777 Walker A/P-loop; other site 701177012778 ATP binding site [chemical binding]; other site 701177012779 Q-loop/lid; other site 701177012780 ABC transporter signature motif; other site 701177012781 Walker B; other site 701177012782 D-loop; other site 701177012783 H-loop/switch region; other site 701177012784 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 701177012785 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 701177012786 dimer interface [polypeptide binding]; other site 701177012787 conserved gate region; other site 701177012788 putative PBP binding loops; other site 701177012789 ABC-ATPase subunit interface; other site 701177012790 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 701177012791 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 701177012792 dimer interface [polypeptide binding]; other site 701177012793 conserved gate region; other site 701177012794 putative PBP binding loops; other site 701177012795 ABC-ATPase subunit interface; other site 701177012796 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 701177012797 Fimbrial protein; Region: Fimbrial; cl01416 701177012798 Fimbrial protein; Region: Fimbrial; cl01416 701177012799 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 701177012800 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 701177012801 fimbrial protein; Provisional; Region: lpfA; PRK15289 701177012802 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 701177012803 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 701177012804 glutaminase active site [active] 701177012805 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 701177012806 dimer interface [polypeptide binding]; other site 701177012807 active site 701177012808 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 701177012809 dimer interface [polypeptide binding]; other site 701177012810 active site 701177012811 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 701177012812 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 701177012813 Substrate binding site; other site 701177012814 Mg++ binding site; other site 701177012815 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 701177012816 active site 701177012817 substrate binding site [chemical binding]; other site 701177012818 CoA binding site [chemical binding]; other site 701177012819 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 701177012820 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 701177012821 gamma subunit interface [polypeptide binding]; other site 701177012822 epsilon subunit interface [polypeptide binding]; other site 701177012823 LBP interface [polypeptide binding]; other site 701177012824 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 701177012825 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 701177012826 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 701177012827 alpha subunit interaction interface [polypeptide binding]; other site 701177012828 Walker A motif; other site 701177012829 ATP binding site [chemical binding]; other site 701177012830 Walker B motif; other site 701177012831 inhibitor binding site; inhibition site 701177012832 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 701177012833 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 701177012834 core domain interface [polypeptide binding]; other site 701177012835 delta subunit interface [polypeptide binding]; other site 701177012836 epsilon subunit interface [polypeptide binding]; other site 701177012837 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 701177012838 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 701177012839 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 701177012840 beta subunit interaction interface [polypeptide binding]; other site 701177012841 Walker A motif; other site 701177012842 ATP binding site [chemical binding]; other site 701177012843 Walker B motif; other site 701177012844 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 701177012845 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 701177012846 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 701177012847 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 701177012848 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 701177012849 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 701177012850 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 701177012851 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 701177012852 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 701177012853 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 701177012854 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 701177012855 S-adenosylmethionine binding site [chemical binding]; other site 701177012856 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 701177012857 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 701177012858 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 701177012859 FMN-binding protein MioC; Provisional; Region: PRK09004 701177012860 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 701177012861 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 701177012862 putative DNA binding site [nucleotide binding]; other site 701177012863 putative Zn2+ binding site [ion binding]; other site 701177012864 AsnC family; Region: AsnC_trans_reg; pfam01037 701177012865 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 701177012866 dimer interface [polypeptide binding]; other site 701177012867 active site 701177012868 hypothetical protein; Provisional; Region: yieM; PRK10997 701177012869 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 701177012870 metal ion-dependent adhesion site (MIDAS); other site 701177012871 regulatory ATPase RavA; Provisional; Region: PRK13531 701177012872 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 701177012873 Walker A motif; other site 701177012874 ATP binding site [chemical binding]; other site 701177012875 Walker B motif; other site 701177012876 arginine finger; other site 701177012877 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 701177012878 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 701177012879 potassium uptake protein; Region: kup; TIGR00794 701177012880 D-ribose pyranase; Provisional; Region: PRK11797 701177012881 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 701177012882 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 701177012883 Walker A/P-loop; other site 701177012884 ATP binding site [chemical binding]; other site 701177012885 Q-loop/lid; other site 701177012886 ABC transporter signature motif; other site 701177012887 Walker B; other site 701177012888 D-loop; other site 701177012889 H-loop/switch region; other site 701177012890 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 701177012891 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 701177012892 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 701177012893 TM-ABC transporter signature motif; other site 701177012894 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 701177012895 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 701177012896 ligand binding site [chemical binding]; other site 701177012897 dimerization interface [polypeptide binding]; other site 701177012898 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 701177012899 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 701177012900 substrate binding site [chemical binding]; other site 701177012901 dimer interface [polypeptide binding]; other site 701177012902 ATP binding site [chemical binding]; other site 701177012903 transcriptional repressor RbsR; Provisional; Region: PRK10423 701177012904 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 701177012905 DNA binding site [nucleotide binding] 701177012906 domain linker motif; other site 701177012907 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 701177012908 dimerization interface [polypeptide binding]; other site 701177012909 ligand binding site [chemical binding]; other site 701177012910 putative transporter; Provisional; Region: PRK10504 701177012911 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177012912 putative substrate translocation pore; other site 701177012913 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177012914 Transcriptional regulators [Transcription]; Region: FadR; COG2186 701177012915 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 701177012916 DNA-binding site [nucleotide binding]; DNA binding site 701177012917 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 701177012918 transcriptional regulator HdfR; Provisional; Region: PRK03601 701177012919 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 701177012920 LysR substrate binding domain; Region: LysR_substrate; pfam03466 701177012921 dimerization interface [polypeptide binding]; other site 701177012922 hypothetical protein; Provisional; Region: PRK11027 701177012923 putative ATP-dependent protease; Provisional; Region: PRK09862 701177012924 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 701177012925 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 701177012926 Walker A motif; other site 701177012927 ATP binding site [chemical binding]; other site 701177012928 Walker B motif; other site 701177012929 arginine finger; other site 701177012930 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 701177012931 ilvG operon leader peptide; Provisional; Region: PRK10424 701177012932 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 701177012933 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 701177012934 PYR/PP interface [polypeptide binding]; other site 701177012935 dimer interface [polypeptide binding]; other site 701177012936 TPP binding site [chemical binding]; other site 701177012937 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 701177012938 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 701177012939 TPP-binding site [chemical binding]; other site 701177012940 dimer interface [polypeptide binding]; other site 701177012941 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 701177012942 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 701177012943 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 701177012944 homodimer interface [polypeptide binding]; other site 701177012945 substrate-cofactor binding pocket; other site 701177012946 catalytic residue [active] 701177012947 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 701177012948 threonine dehydratase; Reviewed; Region: PRK09224 701177012949 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 701177012950 tetramer interface [polypeptide binding]; other site 701177012951 pyridoxal 5'-phosphate binding site [chemical binding]; other site 701177012952 catalytic residue [active] 701177012953 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 701177012954 putative Ile/Val binding site [chemical binding]; other site 701177012955 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 701177012956 putative Ile/Val binding site [chemical binding]; other site 701177012957 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 701177012958 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 701177012959 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 701177012960 putative dimerization interface [polypeptide binding]; other site 701177012961 ketol-acid reductoisomerase; Validated; Region: PRK05225 701177012962 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 701177012963 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 701177012964 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 701177012965 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 701177012966 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 701177012967 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3692 701177012968 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 701177012969 Part of AAA domain; Region: AAA_19; pfam13245 701177012970 Family description; Region: UvrD_C_2; pfam13538 701177012971 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 701177012972 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 701177012973 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 701177012974 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 701177012975 ATP binding site [chemical binding]; other site 701177012976 Mg++ binding site [ion binding]; other site 701177012977 motif III; other site 701177012978 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 701177012979 nucleotide binding region [chemical binding]; other site 701177012980 ATP-binding site [chemical binding]; other site 701177012981 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 701177012982 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 701177012983 catalytic residues [active] 701177012984 putative rho operon leader peptide; Provisional; Region: PRK09979 701177012985 transcription termination factor Rho; Provisional; Region: rho; PRK09376 701177012986 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 701177012987 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 701177012988 RNA binding site [nucleotide binding]; other site 701177012989 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 701177012990 multimer interface [polypeptide binding]; other site 701177012991 Walker A motif; other site 701177012992 ATP binding site [chemical binding]; other site 701177012993 Walker B motif; other site 701177012994 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 701177012995 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 701177012996 Mg++ binding site [ion binding]; other site 701177012997 putative catalytic motif [active] 701177012998 substrate binding site [chemical binding]; other site 701177012999 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 701177013000 Chain length determinant protein; Region: Wzz; pfam02706 701177013001 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 701177013002 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 701177013003 active site 701177013004 homodimer interface [polypeptide binding]; other site 701177013005 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 701177013006 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 701177013007 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 701177013008 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 701177013009 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 701177013010 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 701177013011 NAD binding site [chemical binding]; other site 701177013012 substrate binding site [chemical binding]; other site 701177013013 homodimer interface [polypeptide binding]; other site 701177013014 active site 701177013015 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 701177013016 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 701177013017 substrate binding site; other site 701177013018 tetramer interface; other site 701177013019 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 701177013020 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 701177013021 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 701177013022 inhibitor-cofactor binding pocket; inhibition site 701177013023 pyridoxal 5'-phosphate binding site [chemical binding]; other site 701177013024 catalytic residue [active] 701177013025 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 701177013026 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 701177013027 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 701177013028 putative common antigen polymerase; Provisional; Region: PRK02975 701177013029 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 701177013030 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 701177013031 putative transport protein YifK; Provisional; Region: PRK10746 701177013032 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 701177013033 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 701177013034 FeS/SAM binding site; other site 701177013035 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 701177013036 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 701177013037 Sulfatase; Region: Sulfatase; pfam00884 701177013038 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 701177013039 HemY protein N-terminus; Region: HemY_N; pfam07219 701177013040 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 701177013041 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 701177013042 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 701177013043 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 701177013044 active site 701177013045 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 701177013046 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 701177013047 domain interfaces; other site 701177013048 active site 701177013049 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 701177013050 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 701177013051 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 701177013052 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 701177013053 putative iron binding site [ion binding]; other site 701177013054 hypothetical protein; Provisional; Region: PRK09807 701177013055 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 701177013056 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 701177013057 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 701177013058 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 701177013059 hypothetical protein; Provisional; Region: PRK10963 701177013060 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 701177013061 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 701177013062 active site 701177013063 DNA binding site [nucleotide binding] 701177013064 Int/Topo IB signature motif; other site 701177013065 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 701177013066 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 701177013067 motif II; other site 701177013068 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 701177013069 Part of AAA domain; Region: AAA_19; pfam13245 701177013070 Family description; Region: UvrD_C_2; pfam13538 701177013071 Uncharacterized conserved protein [Function unknown]; Region: COG1912 701177013072 Predicted periplasmic protein [Function unknown]; Region: COG3698 701177013073 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 701177013074 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 701177013075 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 701177013076 Cl binding site [ion binding]; other site 701177013077 oligomer interface [polypeptide binding]; other site 701177013078 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 701177013079 Protein of unknown function (DUF3289); Region: DUF3289; cl11840 701177013080 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085 701177013081 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 701177013082 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 701177013083 EamA-like transporter family; Region: EamA; cl17759 701177013084 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 701177013085 CoenzymeA binding site [chemical binding]; other site 701177013086 subunit interaction site [polypeptide binding]; other site 701177013087 PHB binding site; other site 701177013088 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 701177013089 dimerization interface [polypeptide binding]; other site 701177013090 substrate binding site [chemical binding]; other site 701177013091 active site 701177013092 calcium binding site [ion binding]; other site 701177013093 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 701177013094 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 701177013095 ATP binding site [chemical binding]; other site 701177013096 putative Mg++ binding site [ion binding]; other site 701177013097 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 701177013098 nucleotide binding region [chemical binding]; other site 701177013099 ATP-binding site [chemical binding]; other site 701177013100 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 701177013101 Helicase and RNase D C-terminal; Region: HRDC; smart00341 701177013102 threonine efflux system; Provisional; Region: PRK10229 701177013103 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 701177013104 lysophospholipase L2; Provisional; Region: PRK10749 701177013105 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 701177013106 putative hydrolase; Provisional; Region: PRK10976 701177013107 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 701177013108 active site 701177013109 motif I; other site 701177013110 motif II; other site 701177013111 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 701177013112 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 701177013113 EamA-like transporter family; Region: EamA; pfam00892 701177013114 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 701177013115 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 701177013116 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 701177013117 putative dimerization interface [polypeptide binding]; other site 701177013118 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 701177013119 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 701177013120 THF binding site; other site 701177013121 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 701177013122 substrate binding site [chemical binding]; other site 701177013123 THF binding site; other site 701177013124 zinc-binding site [ion binding]; other site 701177013125 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 701177013126 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 701177013127 uridine phosphorylase; Provisional; Region: PRK11178 701177013128 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 701177013129 DNA recombination protein RmuC; Provisional; Region: PRK10361 701177013130 RmuC family; Region: RmuC; pfam02646 701177013131 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 701177013132 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 701177013133 S-adenosylmethionine binding site [chemical binding]; other site 701177013134 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 701177013135 SCP-2 sterol transfer family; Region: SCP2; pfam02036 701177013136 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 701177013137 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 701177013138 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 701177013139 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 701177013140 sec-independent translocase; Provisional; Region: PRK01770 701177013141 sec-independent translocase; Provisional; Region: tatB; PRK00404 701177013142 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 701177013143 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 701177013144 active site 701177013145 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 701177013146 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 701177013147 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 701177013148 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 701177013149 FMN reductase; Validated; Region: fre; PRK08051 701177013150 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 701177013151 FAD binding pocket [chemical binding]; other site 701177013152 FAD binding motif [chemical binding]; other site 701177013153 phosphate binding motif [ion binding]; other site 701177013154 beta-alpha-beta structure motif; other site 701177013155 NAD binding pocket [chemical binding]; other site 701177013156 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 701177013157 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 701177013158 dimer interface [polypeptide binding]; other site 701177013159 active site 701177013160 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 701177013161 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 701177013162 substrate binding site [chemical binding]; other site 701177013163 oxyanion hole (OAH) forming residues; other site 701177013164 trimer interface [polypeptide binding]; other site 701177013165 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 701177013166 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 701177013167 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 701177013168 proline dipeptidase; Provisional; Region: PRK13607 701177013169 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 701177013170 active site 701177013171 hypothetical protein; Provisional; Region: PRK11568 701177013172 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 701177013173 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 701177013174 potassium transporter; Provisional; Region: PRK10750 701177013175 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 701177013176 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 701177013177 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 701177013178 Walker A motif; other site 701177013179 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 701177013180 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 701177013181 GTP binding site; other site 701177013182 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 701177013183 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 701177013184 serine/threonine protein kinase; Provisional; Region: PRK11768 701177013185 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 701177013186 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 701177013187 catalytic residues [active] 701177013188 hinge region; other site 701177013189 alpha helical domain; other site 701177013190 hypothetical protein; Provisional; Region: PRK11367 701177013191 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 701177013192 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 701177013193 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 701177013194 putative acyl-acceptor binding pocket; other site 701177013195 DNA polymerase I; Provisional; Region: PRK05755 701177013196 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 701177013197 active site 701177013198 metal binding site 1 [ion binding]; metal-binding site 701177013199 putative 5' ssDNA interaction site; other site 701177013200 metal binding site 3; metal-binding site 701177013201 metal binding site 2 [ion binding]; metal-binding site 701177013202 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 701177013203 putative DNA binding site [nucleotide binding]; other site 701177013204 putative metal binding site [ion binding]; other site 701177013205 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 701177013206 active site 701177013207 catalytic site [active] 701177013208 substrate binding site [chemical binding]; other site 701177013209 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 701177013210 active site 701177013211 DNA binding site [nucleotide binding] 701177013212 catalytic site [active] 701177013213 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 701177013214 G1 box; other site 701177013215 GTP/Mg2+ binding site [chemical binding]; other site 701177013216 Switch I region; other site 701177013217 G2 box; other site 701177013218 G3 box; other site 701177013219 Switch II region; other site 701177013220 G4 box; other site 701177013221 G5 box; other site 701177013222 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078 701177013223 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 701177013224 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 701177013225 FeS/SAM binding site; other site 701177013226 HemN C-terminal domain; Region: HemN_C; pfam06969 701177013227 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 701177013228 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 701177013229 active site 701177013230 phosphorylation site [posttranslational modification] 701177013231 intermolecular recognition site; other site 701177013232 dimerization interface [polypeptide binding]; other site 701177013233 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 701177013234 Walker A motif; other site 701177013235 ATP binding site [chemical binding]; other site 701177013236 Walker B motif; other site 701177013237 arginine finger; other site 701177013238 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 701177013239 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 701177013240 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 701177013241 putative active site [active] 701177013242 heme pocket [chemical binding]; other site 701177013243 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 701177013244 dimer interface [polypeptide binding]; other site 701177013245 phosphorylation site [posttranslational modification] 701177013246 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 701177013247 ATP binding site [chemical binding]; other site 701177013248 Mg2+ binding site [ion binding]; other site 701177013249 G-X-G motif; other site 701177013250 glutamine synthetase; Provisional; Region: glnA; PRK09469 701177013251 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 701177013252 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 701177013253 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 701177013254 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 701177013255 G1 box; other site 701177013256 putative GEF interaction site [polypeptide binding]; other site 701177013257 GTP/Mg2+ binding site [chemical binding]; other site 701177013258 Switch I region; other site 701177013259 G2 box; other site 701177013260 G3 box; other site 701177013261 Switch II region; other site 701177013262 G4 box; other site 701177013263 G5 box; other site 701177013264 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 701177013265 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 701177013266 transcriptional regulator protein; Region: phnR; TIGR03337 701177013267 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 701177013268 DNA-binding site [nucleotide binding]; DNA binding site 701177013269 UTRA domain; Region: UTRA; pfam07702 701177013270 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 701177013271 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177013272 putative substrate translocation pore; other site 701177013273 Major Facilitator Superfamily; Region: MFS_1; pfam07690 701177013274 outer membrane porin L; Provisional; Region: ompL; PRK09980 701177013275 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 701177013276 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177013277 putative substrate translocation pore; other site 701177013278 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 701177013279 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 701177013280 alpha-glucosidase; Provisional; Region: PRK10426 701177013281 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 701177013282 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 701177013283 putative active site [active] 701177013284 putative catalytic site [active] 701177013285 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 701177013286 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 701177013287 active site 701177013288 catalytic residues [active] 701177013289 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 701177013290 dimerization interface [polypeptide binding]; other site 701177013291 putative active cleft [active] 701177013292 Tagatose-1,6-bisphosphate aldolase [Carbohydrate transport and metabolism]; Region: LacD; COG3684 701177013293 catalytic residue [active] 701177013294 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 701177013295 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 701177013296 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 701177013297 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 701177013298 substrate binding site [chemical binding]; other site 701177013299 ATP binding site [chemical binding]; other site 701177013300 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 701177013301 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 701177013302 putative DNA binding site [nucleotide binding]; other site 701177013303 putative Zn2+ binding site [ion binding]; other site 701177013304 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 701177013305 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 701177013306 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 701177013307 motif II; other site 701177013308 hypothetical protein; Reviewed; Region: PRK01637 701177013309 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 701177013310 putative active site [active] 701177013311 dimerization interface [polypeptide binding]; other site 701177013312 putative tRNAtyr binding site [nucleotide binding]; other site 701177013313 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 701177013314 Coenzyme A binding pocket [chemical binding]; other site 701177013315 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 701177013316 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 701177013317 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 701177013318 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 701177013319 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 701177013320 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 701177013321 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 701177013322 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 701177013323 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 701177013324 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 701177013325 putative frv operon regulatory protein; Provisional; Region: PRK09863 701177013326 HTH domain; Region: HTH_11; pfam08279 701177013327 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 701177013328 active site 701177013329 phosphorylation site [posttranslational modification] 701177013330 putative peptidase; Provisional; Region: PRK09864 701177013331 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 701177013332 oligomer interface [polypeptide binding]; other site 701177013333 active site 701177013334 metal binding site [ion binding]; metal-binding site 701177013335 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 701177013336 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 701177013337 active site 701177013338 P-loop; other site 701177013339 phosphorylation site [posttranslational modification] 701177013340 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 701177013341 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 701177013342 active site 701177013343 phosphorylation site [posttranslational modification] 701177013344 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 701177013345 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 701177013346 intersubunit interface [polypeptide binding]; other site 701177013347 active site 701177013348 Zn2+ binding site [ion binding]; other site 701177013349 L-rhamnose isomerase; Provisional; Region: PRK01076 701177013350 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 701177013351 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 701177013352 N- and C-terminal domain interface [polypeptide binding]; other site 701177013353 active site 701177013354 putative catalytic site [active] 701177013355 metal binding site [ion binding]; metal-binding site 701177013356 ATP binding site [chemical binding]; other site 701177013357 rhamnulokinase; Provisional; Region: rhaB; PRK10640 701177013358 carbohydrate binding site [chemical binding]; other site 701177013359 transcriptional activator RhaS; Provisional; Region: PRK13503 701177013360 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 701177013361 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 701177013362 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 701177013363 transcriptional activator RhaR; Provisional; Region: PRK13500 701177013364 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 701177013365 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 701177013366 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 701177013367 superoxide dismutase; Provisional; Region: PRK10925 701177013368 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 701177013369 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 701177013370 2-keto-3-deoxygluconate transporter; Region: kdgT; TIGR00793 701177013371 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 701177013372 MOSC domain; Region: MOSC; pfam03473 701177013373 3-alpha domain; Region: 3-alpha; pfam03475 701177013374 two-component sensor protein; Provisional; Region: cpxA; PRK09470 701177013375 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 701177013376 dimerization interface [polypeptide binding]; other site 701177013377 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 701177013378 dimer interface [polypeptide binding]; other site 701177013379 phosphorylation site [posttranslational modification] 701177013380 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 701177013381 ATP binding site [chemical binding]; other site 701177013382 Mg2+ binding site [ion binding]; other site 701177013383 G-X-G motif; other site 701177013384 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 701177013385 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 701177013386 active site 701177013387 intermolecular recognition site; other site 701177013388 dimerization interface [polypeptide binding]; other site 701177013389 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 701177013390 DNA binding site [nucleotide binding] 701177013391 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 701177013392 dimer interface [polypeptide binding]; other site 701177013393 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 701177013394 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 701177013395 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 701177013396 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 701177013397 active site 701177013398 ADP/pyrophosphate binding site [chemical binding]; other site 701177013399 dimerization interface [polypeptide binding]; other site 701177013400 allosteric effector site; other site 701177013401 fructose-1,6-bisphosphate binding site; other site 701177013402 sulfate transporter subunit; Provisional; Region: PRK10752 701177013403 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 701177013404 CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672 701177013405 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 701177013406 triosephosphate isomerase; Provisional; Region: PRK14567 701177013407 substrate binding site [chemical binding]; other site 701177013408 dimer interface [polypeptide binding]; other site 701177013409 catalytic triad [active] 701177013410 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 701177013411 Predicted membrane protein [Function unknown]; Region: COG3152 701177013412 hypothetical protein; Provisional; Region: PRK09981 701177013413 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 701177013414 Ligand Binding Site [chemical binding]; other site 701177013415 ferredoxin-NADP reductase; Provisional; Region: PRK10926 701177013416 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 701177013417 FAD binding pocket [chemical binding]; other site 701177013418 FAD binding motif [chemical binding]; other site 701177013419 phosphate binding motif [ion binding]; other site 701177013420 beta-alpha-beta structure motif; other site 701177013421 NAD binding pocket [chemical binding]; other site 701177013422 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 701177013423 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 701177013424 putative active site [active] 701177013425 glycerol kinase; Provisional; Region: glpK; PRK00047 701177013426 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 701177013427 N- and C-terminal domain interface [polypeptide binding]; other site 701177013428 active site 701177013429 MgATP binding site [chemical binding]; other site 701177013430 catalytic site [active] 701177013431 metal binding site [ion binding]; metal-binding site 701177013432 glycerol binding site [chemical binding]; other site 701177013433 homotetramer interface [polypeptide binding]; other site 701177013434 homodimer interface [polypeptide binding]; other site 701177013435 FBP binding site [chemical binding]; other site 701177013436 protein IIAGlc interface [polypeptide binding]; other site 701177013437 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 701177013438 amphipathic channel; other site 701177013439 Asn-Pro-Ala signature motifs; other site 701177013440 septal ring assembly protein ZapB; Provisional; Region: PRK15422 701177013441 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 701177013442 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 701177013443 UbiA prenyltransferase family; Region: UbiA; pfam01040 701177013444 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 701177013445 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 701177013446 Walker A motif; other site 701177013447 ATP binding site [chemical binding]; other site 701177013448 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 701177013449 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 701177013450 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 701177013451 active site 701177013452 HslU subunit interaction site [polypeptide binding]; other site 701177013453 essential cell division protein FtsN; Provisional; Region: PRK10927 701177013454 cell division protein FtsN; Provisional; Region: PRK12757 701177013455 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 701177013456 DNA binding site [nucleotide binding] 701177013457 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 701177013458 domain linker motif; other site 701177013459 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 701177013460 dimerization interface [polypeptide binding]; other site 701177013461 ligand binding site [chemical binding]; other site 701177013462 primosome assembly protein PriA; Validated; Region: PRK05580 701177013463 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 701177013464 ATP binding site [chemical binding]; other site 701177013465 putative Mg++ binding site [ion binding]; other site 701177013466 helicase superfamily c-terminal domain; Region: HELICc; smart00490 701177013467 ATP-binding site [chemical binding]; other site 701177013468 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 701177013469 PAAR motif; Region: PAAR_motif; cl15808 701177013470 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 701177013471 RHS Repeat; Region: RHS_repeat; pfam05593 701177013472 RHS Repeat; Region: RHS_repeat; pfam05593 701177013473 RHS Repeat; Region: RHS_repeat; pfam05593 701177013474 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 701177013475 RHS Repeat; Region: RHS_repeat; pfam05593 701177013476 RHS Repeat; Region: RHS_repeat; pfam05593 701177013477 RHS protein; Region: RHS; pfam03527 701177013478 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 701177013479 Domain of unknown function (DUF4329); Region: DUF4329; pfam14220 701177013480 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 701177013481 hypothetical protein; Provisional; Region: PRK10030 701177013482 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 701177013483 dimerization interface [polypeptide binding]; other site 701177013484 DNA binding site [nucleotide binding] 701177013485 corepressor binding sites; other site 701177013486 cystathionine gamma-synthase; Provisional; Region: PRK08045 701177013487 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 701177013488 homodimer interface [polypeptide binding]; other site 701177013489 substrate-cofactor binding pocket; other site 701177013490 pyridoxal 5'-phosphate binding site [chemical binding]; other site 701177013491 catalytic residue [active] 701177013492 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 701177013493 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 701177013494 putative catalytic residues [active] 701177013495 putative nucleotide binding site [chemical binding]; other site 701177013496 putative aspartate binding site [chemical binding]; other site 701177013497 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 701177013498 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 701177013499 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 701177013500 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 701177013501 FAD binding site [chemical binding]; other site 701177013502 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 701177013503 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 701177013504 heme binding site [chemical binding]; other site 701177013505 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 701177013506 EamA-like transporter family; Region: EamA; pfam00892 701177013507 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 701177013508 EamA-like transporter family; Region: EamA; pfam00892 701177013509 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738 701177013510 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 701177013511 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 701177013512 dimer interface [polypeptide binding]; other site 701177013513 active site 701177013514 metal binding site [ion binding]; metal-binding site 701177013515 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 701177013516 active site 701177013517 intersubunit interactions; other site 701177013518 catalytic residue [active] 701177013519 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 701177013520 dimerization domain swap beta strand [polypeptide binding]; other site 701177013521 regulatory protein interface [polypeptide binding]; other site 701177013522 active site 701177013523 regulatory phosphorylation site [posttranslational modification]; other site 701177013524 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 701177013525 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 701177013526 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 701177013527 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 701177013528 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 701177013529 active site 701177013530 phosphorylation site [posttranslational modification] 701177013531 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 701177013532 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 701177013533 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 701177013534 active site 701177013535 P-loop; other site 701177013536 phosphorylation site [posttranslational modification] 701177013537 putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983 701177013538 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 701177013539 dimer interface [polypeptide binding]; other site 701177013540 active site 701177013541 glycine loop; other site 701177013542 pyruvate formate lyase II activase; Provisional; Region: PRK10076 701177013543 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 701177013544 active site 701177013545 P-loop; other site 701177013546 phosphorylation site [posttranslational modification] 701177013547 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 701177013548 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 701177013549 hypothetical protein; Provisional; Region: PRK10649 701177013550 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 701177013551 Sulfatase; Region: Sulfatase; pfam00884 701177013552 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 701177013553 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 701177013554 acetylornithine deacetylase; Provisional; Region: PRK05111 701177013555 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 701177013556 metal binding site [ion binding]; metal-binding site 701177013557 putative dimer interface [polypeptide binding]; other site 701177013558 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 701177013559 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 701177013560 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 701177013561 nucleotide binding site [chemical binding]; other site 701177013562 N-acetyl-L-glutamate binding site [chemical binding]; other site 701177013563 argininosuccinate lyase; Provisional; Region: PRK04833 701177013564 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 701177013565 active sites [active] 701177013566 tetramer interface [polypeptide binding]; other site 701177013567 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 701177013568 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 701177013569 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 701177013570 dimerization interface [polypeptide binding]; other site 701177013571 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 701177013572 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 701177013573 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 701177013574 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 701177013575 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 701177013576 metal binding site [ion binding]; metal-binding site 701177013577 putative dimer interface [polypeptide binding]; other site 701177013578 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177013579 metabolite-proton symporter; Region: 2A0106; TIGR00883 701177013580 putative substrate translocation pore; other site 701177013581 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 701177013582 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 701177013583 hypothetical protein; Provisional; Region: PRK11056 701177013584 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 701177013585 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 701177013586 S-adenosylmethionine binding site [chemical binding]; other site 701177013587 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 701177013588 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 701177013589 N-terminal plug; other site 701177013590 ligand-binding site [chemical binding]; other site 701177013591 glutamate racemase; Provisional; Region: PRK00865 701177013592 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 701177013593 FAD binding domain; Region: FAD_binding_4; pfam01565 701177013594 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 701177013595 Biotin operon repressor [Transcription]; Region: BirA; COG1654 701177013596 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 701177013597 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 701177013598 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 701177013599 pantothenate kinase; Provisional; Region: PRK05439 701177013600 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 701177013601 ATP-binding site [chemical binding]; other site 701177013602 CoA-binding site [chemical binding]; other site 701177013603 Mg2+-binding site [ion binding]; other site 701177013604 elongation factor Tu; Reviewed; Region: PRK00049 701177013605 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 701177013606 G1 box; other site 701177013607 GEF interaction site [polypeptide binding]; other site 701177013608 GTP/Mg2+ binding site [chemical binding]; other site 701177013609 Switch I region; other site 701177013610 G2 box; other site 701177013611 G3 box; other site 701177013612 Switch II region; other site 701177013613 G4 box; other site 701177013614 G5 box; other site 701177013615 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 701177013616 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 701177013617 Antibiotic Binding Site [chemical binding]; other site 701177013618 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 701177013619 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 701177013620 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 701177013621 putative homodimer interface [polypeptide binding]; other site 701177013622 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 701177013623 heterodimer interface [polypeptide binding]; other site 701177013624 homodimer interface [polypeptide binding]; other site 701177013625 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 701177013626 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 701177013627 23S rRNA interface [nucleotide binding]; other site 701177013628 L7/L12 interface [polypeptide binding]; other site 701177013629 putative thiostrepton binding site; other site 701177013630 L25 interface [polypeptide binding]; other site 701177013631 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 701177013632 mRNA/rRNA interface [nucleotide binding]; other site 701177013633 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 701177013634 23S rRNA interface [nucleotide binding]; other site 701177013635 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 701177013636 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 701177013637 core dimer interface [polypeptide binding]; other site 701177013638 peripheral dimer interface [polypeptide binding]; other site 701177013639 L10 interface [polypeptide binding]; other site 701177013640 L11 interface [polypeptide binding]; other site 701177013641 putative EF-Tu interaction site [polypeptide binding]; other site 701177013642 putative EF-G interaction site [polypeptide binding]; other site 701177013643 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 701177013644 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 701177013645 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 701177013646 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 701177013647 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 701177013648 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 701177013649 RPB3 interaction site [polypeptide binding]; other site 701177013650 RPB1 interaction site [polypeptide binding]; other site 701177013651 RPB11 interaction site [polypeptide binding]; other site 701177013652 RPB10 interaction site [polypeptide binding]; other site 701177013653 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 701177013654 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 701177013655 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 701177013656 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 701177013657 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 701177013658 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 701177013659 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 701177013660 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 701177013661 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 701177013662 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 701177013663 DNA binding site [nucleotide binding] 701177013664 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 701177013665 stationary phase growth adaptation protein; Provisional; Region: PRK09717 701177013666 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 701177013667 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 701177013668 FeS/SAM binding site; other site 701177013669 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 701177013670 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 701177013671 ThiS interaction site; other site 701177013672 putative active site [active] 701177013673 tetramer interface [polypeptide binding]; other site 701177013674 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 701177013675 thiS-thiF/thiG interaction site; other site 701177013676 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 701177013677 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 701177013678 ATP binding site [chemical binding]; other site 701177013679 substrate interface [chemical binding]; other site 701177013680 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 701177013681 thiamine phosphate binding site [chemical binding]; other site 701177013682 active site 701177013683 pyrophosphate binding site [ion binding]; other site 701177013684 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 701177013685 ThiC-associated domain; Region: ThiC-associated; pfam13667 701177013686 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 701177013687 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 701177013688 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 701177013689 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 701177013690 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 701177013691 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 701177013692 putative NADH binding site [chemical binding]; other site 701177013693 putative active site [active] 701177013694 nudix motif; other site 701177013695 putative metal binding site [ion binding]; other site 701177013696 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 701177013697 substrate binding site [chemical binding]; other site 701177013698 active site 701177013699 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 701177013700 Active_site [active] 701177013701 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 701177013702 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 701177013703 IHF dimer interface [polypeptide binding]; other site 701177013704 IHF - DNA interface [nucleotide binding]; other site 701177013705 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 701177013706 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 701177013707 dimer interface [polypeptide binding]; other site 701177013708 sensor protein ZraS; Provisional; Region: PRK10364 701177013709 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 701177013710 dimer interface [polypeptide binding]; other site 701177013711 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 701177013712 ATP binding site [chemical binding]; other site 701177013713 Mg2+ binding site [ion binding]; other site 701177013714 G-X-G motif; other site 701177013715 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 701177013716 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 701177013717 active site 701177013718 phosphorylation site [posttranslational modification] 701177013719 intermolecular recognition site; other site 701177013720 dimerization interface [polypeptide binding]; other site 701177013721 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 701177013722 Walker A motif; other site 701177013723 ATP binding site [chemical binding]; other site 701177013724 Walker B motif; other site 701177013725 arginine finger; other site 701177013726 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 701177013727 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 701177013728 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 701177013729 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 701177013730 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 701177013731 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 701177013732 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 701177013733 purine monophosphate binding site [chemical binding]; other site 701177013734 dimer interface [polypeptide binding]; other site 701177013735 putative catalytic residues [active] 701177013736 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 701177013737 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 701177013738 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 701177013739 Coenzyme A binding pocket [chemical binding]; other site 701177013740 homoserine O-succinyltransferase; Provisional; Region: PRK05368 701177013741 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 701177013742 proposed active site lysine [active] 701177013743 conserved cys residue [active] 701177013744 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 701177013745 malate synthase A; Region: malate_syn_A; TIGR01344 701177013746 active site 701177013747 isocitrate lyase; Provisional; Region: PRK15063 701177013748 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 701177013749 tetramer interface [polypeptide binding]; other site 701177013750 active site 701177013751 Mg2+/Mn2+ binding site [ion binding]; other site 701177013752 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 701177013753 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 701177013754 transcriptional repressor IclR; Provisional; Region: PRK11569 701177013755 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 701177013756 Bacterial transcriptional regulator; Region: IclR; pfam01614 701177013757 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 701177013758 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 701177013759 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 701177013760 substrate binding pocket [chemical binding]; other site 701177013761 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 701177013762 B12 binding site [chemical binding]; other site 701177013763 cobalt ligand [ion binding]; other site 701177013764 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 701177013765 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 701177013766 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 701177013767 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 701177013768 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 701177013769 active site pocket [active] 701177013770 oxyanion hole [active] 701177013771 catalytic triad [active] 701177013772 active site nucleophile [active] 701177013773 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 701177013774 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 701177013775 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 701177013776 putative NAD(P) binding site [chemical binding]; other site 701177013777 catalytic Zn binding site [ion binding]; other site 701177013778 PTS system, mannose/fructose/sorbose family, IID component; Region: EIID-AGA; TIGR00828 701177013779 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 701177013780 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 701177013781 active site 701177013782 phosphorylation site [posttranslational modification] 701177013783 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 701177013784 active pocket/dimerization site; other site 701177013785 active site 701177013786 phosphorylation site [posttranslational modification] 701177013787 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 701177013788 classical (c) SDRs; Region: SDR_c; cd05233 701177013789 NAD(P) binding site [chemical binding]; other site 701177013790 active site 701177013791 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 701177013792 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 701177013793 putative DNA binding site [nucleotide binding]; other site 701177013794 putative Zn2+ binding site [ion binding]; other site 701177013795 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 701177013796 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 701177013797 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 701177013798 RNA binding surface [nucleotide binding]; other site 701177013799 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 701177013800 probable active site [active] 701177013801 hypothetical protein; Provisional; Region: PRK10515 701177013802 aspartate kinase III; Validated; Region: PRK09084 701177013803 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 701177013804 nucleotide binding site [chemical binding]; other site 701177013805 substrate binding site [chemical binding]; other site 701177013806 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 701177013807 lysine allosteric regulatory site; other site 701177013808 dimer interface [polypeptide binding]; other site 701177013809 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 701177013810 dimer interface [polypeptide binding]; other site 701177013811 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 701177013812 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 701177013813 active site 701177013814 dimer interface [polypeptide binding]; other site 701177013815 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 701177013816 dimer interface [polypeptide binding]; other site 701177013817 active site 701177013818 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 701177013819 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 701177013820 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 701177013821 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 701177013822 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 701177013823 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177013824 putative substrate translocation pore; other site 701177013825 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177013826 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 701177013827 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 701177013828 dimer interface [polypeptide binding]; other site 701177013829 conserved gate region; other site 701177013830 putative PBP binding loops; other site 701177013831 ABC-ATPase subunit interface; other site 701177013832 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 701177013833 dimer interface [polypeptide binding]; other site 701177013834 conserved gate region; other site 701177013835 putative PBP binding loops; other site 701177013836 ABC-ATPase subunit interface; other site 701177013837 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 701177013838 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 701177013839 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 701177013840 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 701177013841 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 701177013842 Walker A/P-loop; other site 701177013843 ATP binding site [chemical binding]; other site 701177013844 Q-loop/lid; other site 701177013845 ABC transporter signature motif; other site 701177013846 Walker B; other site 701177013847 D-loop; other site 701177013848 H-loop/switch region; other site 701177013849 TOBE domain; Region: TOBE_2; pfam08402 701177013850 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 701177013851 trimer interface; other site 701177013852 sugar binding site [chemical binding]; other site 701177013853 maltose regulon periplasmic protein; Provisional; Region: PRK10564 701177013854 hypothetical protein; Validated; Region: PRK09718 701177013855 SopA-like central domain; Region: SopA; pfam13981 701177013856 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 701177013857 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 701177013858 UbiA prenyltransferase family; Region: UbiA; pfam01040 701177013859 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 701177013860 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 701177013861 putative acyl-acceptor binding pocket; other site 701177013862 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 701177013863 LexA repressor; Validated; Region: PRK00215 701177013864 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 701177013865 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 701177013866 Catalytic site [active] 701177013867 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 701177013868 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 701177013869 hypothetical protein; Provisional; Region: PRK10428 701177013870 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 701177013871 metal binding site 2 [ion binding]; metal-binding site 701177013872 putative DNA binding helix; other site 701177013873 metal binding site 1 [ion binding]; metal-binding site 701177013874 dimer interface [polypeptide binding]; other site 701177013875 structural Zn2+ binding site [ion binding]; other site 701177013876 Protein of unknown function (DUF2713); Region: DUF2713; pfam10897 701177013877 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 701177013878 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 701177013879 FMN binding site [chemical binding]; other site 701177013880 active site 701177013881 catalytic residues [active] 701177013882 substrate binding site [chemical binding]; other site 701177013883 phage shock protein G; Reviewed; Region: pspG; PRK09459 701177013884 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 701177013885 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 701177013886 NADP binding site [chemical binding]; other site 701177013887 dimer interface [polypeptide binding]; other site 701177013888 replicative DNA helicase; Provisional; Region: PRK08006 701177013889 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 701177013890 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 701177013891 Walker A motif; other site 701177013892 ATP binding site [chemical binding]; other site 701177013893 Walker B motif; other site 701177013894 DNA binding loops [nucleotide binding] 701177013895 alanine racemase; Reviewed; Region: alr; PRK00053 701177013896 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 701177013897 active site 701177013898 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 701177013899 substrate binding site [chemical binding]; other site 701177013900 catalytic residues [active] 701177013901 dimer interface [polypeptide binding]; other site 701177013902 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 701177013903 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 701177013904 pyridoxal 5'-phosphate binding site [chemical binding]; other site 701177013905 homodimer interface [polypeptide binding]; other site 701177013906 catalytic residue [active] 701177013907 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 701177013908 active site 701177013909 motif I; other site 701177013910 motif II; other site 701177013911 secondary thiamine-phosphate synthase enzyme; Region: TIGR00149_YjbQ 701177013912 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 701177013913 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 701177013914 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 701177013915 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 701177013916 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 701177013917 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 701177013918 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 701177013919 dimer interface [polypeptide binding]; other site 701177013920 ssDNA binding site [nucleotide binding]; other site 701177013921 tetramer (dimer of dimers) interface [polypeptide binding]; other site 701177013922 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 701177013923 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 701177013924 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 701177013925 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 701177013926 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 701177013927 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 701177013928 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 701177013929 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 701177013930 DNA binding residues [nucleotide binding] 701177013931 dimer interface [polypeptide binding]; other site 701177013932 [2Fe-2S] cluster binding site [ion binding]; other site 701177013933 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 701177013934 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 701177013935 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 701177013936 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 701177013937 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 701177013938 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 701177013939 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 701177013940 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 701177013941 Na binding site [ion binding]; other site 701177013942 Predicted membrane protein [Function unknown]; Region: COG3162 701177013943 acetyl-CoA synthetase; Provisional; Region: PRK00174 701177013944 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 701177013945 active site 701177013946 CoA binding site [chemical binding]; other site 701177013947 acyl-activating enzyme (AAE) consensus motif; other site 701177013948 AMP binding site [chemical binding]; other site 701177013949 acetate binding site [chemical binding]; other site 701177013950 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 701177013951 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 701177013952 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 701177013953 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 701177013954 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 701177013955 heme lyase subunit NrfE; Provisional; Region: PRK10369 701177013956 formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144 701177013957 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 701177013958 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 701177013959 binding surface 701177013960 TPR motif; other site 701177013961 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 701177013962 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 701177013963 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 701177013964 Sel1-like repeats; Region: SEL1; smart00671 701177013965 putative outer membrane efflux protein MdtP; Provisional; Region: PRK09915 701177013966 multidrug efflux system protein MdtO; Provisional; Region: PRK11427 701177013967 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 701177013968 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 701177013969 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 701177013970 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 701177013971 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 701177013972 active site 701177013973 phosphorylation site [posttranslational modification] 701177013974 intermolecular recognition site; other site 701177013975 dimerization interface [polypeptide binding]; other site 701177013976 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 701177013977 DNA binding site [nucleotide binding] 701177013978 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 701177013979 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 701177013980 substrate binding site [chemical binding]; other site 701177013981 ATP binding site [chemical binding]; other site 701177013982 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 701177013983 intersubunit interface [polypeptide binding]; other site 701177013984 active site 701177013985 zinc binding site [ion binding]; other site 701177013986 Na+ binding site [ion binding]; other site 701177013987 Protein of unknown function (DUF1498); Region: DUF1498; pfam07385 701177013988 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 701177013989 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 701177013990 putative ligand binding site [chemical binding]; other site 701177013991 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 701177013992 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 701177013993 TM-ABC transporter signature motif; other site 701177013994 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 701177013995 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 701177013996 Walker A/P-loop; other site 701177013997 ATP binding site [chemical binding]; other site 701177013998 Q-loop/lid; other site 701177013999 ABC transporter signature motif; other site 701177014000 Walker B; other site 701177014001 D-loop; other site 701177014002 H-loop/switch region; other site 701177014003 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 701177014004 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 701177014005 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 701177014006 dimerization interface [polypeptide binding]; other site 701177014007 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 701177014008 dimer interface [polypeptide binding]; other site 701177014009 phosphorylation site [posttranslational modification] 701177014010 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 701177014011 ATP binding site [chemical binding]; other site 701177014012 Mg2+ binding site [ion binding]; other site 701177014013 G-X-G motif; other site 701177014014 Response regulator receiver domain; Region: Response_reg; pfam00072 701177014015 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 701177014016 active site 701177014017 phosphorylation site [posttranslational modification] 701177014018 intermolecular recognition site; other site 701177014019 dimerization interface [polypeptide binding]; other site 701177014020 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 701177014021 putative hydrolase; Provisional; Region: PRK02113 701177014022 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 701177014023 Coenzyme A binding pocket [chemical binding]; other site 701177014024 ribose 1,5-bisphosphokinase; Provisional; Region: PRK10078 701177014025 AAA domain; Region: AAA_18; pfam13238 701177014026 active site 701177014027 Metal-dependent hydrolase involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3454 701177014028 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 701177014029 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 701177014030 active site 701177014031 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 701177014032 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 701177014033 Walker A/P-loop; other site 701177014034 ATP binding site [chemical binding]; other site 701177014035 Q-loop/lid; other site 701177014036 ABC transporter signature motif; other site 701177014037 Walker B; other site 701177014038 D-loop; other site 701177014039 H-loop/switch region; other site 701177014040 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 701177014041 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 701177014042 Walker A/P-loop; other site 701177014043 ATP binding site [chemical binding]; other site 701177014044 Q-loop/lid; other site 701177014045 ABC transporter signature motif; other site 701177014046 Walker B; other site 701177014047 D-loop; other site 701177014048 H-loop/switch region; other site 701177014049 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 701177014050 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 701177014051 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnI; COG3626 701177014052 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnH; COG3625 701177014053 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 701177014054 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 701177014055 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 701177014056 DNA-binding site [nucleotide binding]; DNA binding site 701177014057 UTRA domain; Region: UTRA; pfam07702 701177014058 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 701177014059 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 701177014060 dimer interface [polypeptide binding]; other site 701177014061 conserved gate region; other site 701177014062 putative PBP binding loops; other site 701177014063 ABC-ATPase subunit interface; other site 701177014064 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 701177014065 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 701177014066 phosphonate/organophosphate ester transporter subunit; Provisional; Region: PRK09984 701177014067 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 701177014068 Walker A/P-loop; other site 701177014069 ATP binding site [chemical binding]; other site 701177014070 Q-loop/lid; other site 701177014071 ABC transporter signature motif; other site 701177014072 Walker B; other site 701177014073 D-loop; other site 701177014074 H-loop/switch region; other site 701177014075 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 701177014076 dimer interface [polypeptide binding]; other site 701177014077 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 701177014078 hypothetical protein; Provisional; Region: PRK10220 701177014079 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 701177014080 PhnA protein; Region: PhnA; pfam03831 701177014081 hypothetical protein; Provisional; Region: PRK09866 701177014082 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 701177014083 G1 box; other site 701177014084 GTP/Mg2+ binding site [chemical binding]; other site 701177014085 G2 box; other site 701177014086 Switch I region; other site 701177014087 G3 box; other site 701177014088 Switch II region; other site 701177014089 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 701177014090 G2 box; other site 701177014091 Switch I region; other site 701177014092 G3 box; other site 701177014093 Switch II region; other site 701177014094 G4 box; other site 701177014095 G5 box; other site 701177014096 YjcZ-like protein; Region: YjcZ; pfam13990 701177014097 proline/glycine betaine transporter; Provisional; Region: PRK10642 701177014098 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177014099 putative substrate translocation pore; other site 701177014100 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 701177014101 sensor protein BasS/PmrB; Provisional; Region: PRK10755 701177014102 HAMP domain; Region: HAMP; pfam00672 701177014103 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 701177014104 dimer interface [polypeptide binding]; other site 701177014105 phosphorylation site [posttranslational modification] 701177014106 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 701177014107 ATP binding site [chemical binding]; other site 701177014108 Mg2+ binding site [ion binding]; other site 701177014109 G-X-G motif; other site 701177014110 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 701177014111 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 701177014112 active site 701177014113 phosphorylation site [posttranslational modification] 701177014114 intermolecular recognition site; other site 701177014115 dimerization interface [polypeptide binding]; other site 701177014116 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 701177014117 DNA binding site [nucleotide binding] 701177014118 putative metal dependent hydrolase; Provisional; Region: PRK11598 701177014119 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 701177014120 Sulfatase; Region: Sulfatase; pfam00884 701177014121 arginine:agmatin antiporter; Provisional; Region: PRK10644 701177014122 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 701177014123 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 701177014124 arginine decarboxylase; Provisional; Region: PRK15029 701177014125 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 701177014126 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 701177014127 homodimer interface [polypeptide binding]; other site 701177014128 pyridoxal 5'-phosphate binding site [chemical binding]; other site 701177014129 catalytic residue [active] 701177014130 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 701177014131 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 701177014132 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 701177014133 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 701177014134 alpha-galactosidase; Provisional; Region: PRK15076 701177014135 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 701177014136 NAD binding site [chemical binding]; other site 701177014137 sugar binding site [chemical binding]; other site 701177014138 divalent metal binding site [ion binding]; other site 701177014139 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 701177014140 dimer interface [polypeptide binding]; other site 701177014141 melibiose:sodium symporter; Provisional; Region: PRK10429 701177014142 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 701177014143 hypothetical protein; Provisional; Region: PRK09867 701177014144 fumarate hydratase; Provisional; Region: PRK15389 701177014145 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 701177014146 Fumarase C-terminus; Region: Fumerase_C; pfam05683 701177014147 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 701177014148 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 701177014149 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 701177014150 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 701177014151 active site 701177014152 phosphorylation site [posttranslational modification] 701177014153 intermolecular recognition site; other site 701177014154 dimerization interface [polypeptide binding]; other site 701177014155 Transcriptional regulator; Region: CitT; pfam12431 701177014156 sensory histidine kinase DcuS; Provisional; Region: PRK11086 701177014157 PAS domain; Region: PAS; smart00091 701177014158 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 701177014159 ATP binding site [chemical binding]; other site 701177014160 Mg2+ binding site [ion binding]; other site 701177014161 G-X-G motif; other site 701177014162 Uncharacterized conserved protein [Function unknown]; Region: COG3592 701177014163 Predicted acetyltransferase [General function prediction only]; Region: COG2388 701177014164 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 701177014165 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 701177014166 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 701177014167 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 701177014168 dimer interface [polypeptide binding]; other site 701177014169 putative anticodon binding site; other site 701177014170 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 701177014171 motif 1; other site 701177014172 active site 701177014173 motif 2; other site 701177014174 motif 3; other site 701177014175 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 701177014176 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177014177 putative substrate translocation pore; other site 701177014178 POT family; Region: PTR2; pfam00854 701177014179 lysine decarboxylase CadA; Provisional; Region: PRK15400 701177014180 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 701177014181 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 701177014182 homodimer interface [polypeptide binding]; other site 701177014183 pyridoxal 5'-phosphate binding site [chemical binding]; other site 701177014184 catalytic residue [active] 701177014185 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 701177014186 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 701177014187 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 701177014188 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 701177014189 DNA binding site [nucleotide binding] 701177014190 putative transcriptional regulator; Provisional; Region: PRK11640 701177014191 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 701177014192 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 701177014193 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 701177014194 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 701177014195 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 701177014196 DsbD alpha interface [polypeptide binding]; other site 701177014197 catalytic residues [active] 701177014198 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 701177014199 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 701177014200 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 701177014201 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 701177014202 Aspartase; Region: Aspartase; cd01357 701177014203 active sites [active] 701177014204 tetramer interface [polypeptide binding]; other site 701177014205 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 701177014206 putative transporter; Provisional; Region: PRK11021 701177014207 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 701177014208 oligomerisation interface [polypeptide binding]; other site 701177014209 mobile loop; other site 701177014210 roof hairpin; other site 701177014211 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 701177014212 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 701177014213 ring oligomerisation interface [polypeptide binding]; other site 701177014214 ATP/Mg binding site [chemical binding]; other site 701177014215 stacking interactions; other site 701177014216 hinge regions; other site 701177014217 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 701177014218 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 701177014219 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 701177014220 FeS/SAM binding site; other site 701177014221 elongation factor P; Validated; Region: PRK00529 701177014222 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 701177014223 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 701177014224 RNA binding site [nucleotide binding]; other site 701177014225 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 701177014226 RNA binding site [nucleotide binding]; other site 701177014227 entericidin A; Provisional; Region: PRK09810 701177014228 entericidin B membrane lipoprotein; Provisional; Region: PRK10081 701177014229 multidrug efflux system protein; Provisional; Region: PRK11431 701177014230 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 701177014231 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 701177014232 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 701177014233 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 701177014234 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 701177014235 Iron-sulfur protein interface; other site 701177014236 proximal quinone binding site [chemical binding]; other site 701177014237 C-subunit interface; other site 701177014238 distal quinone binding site; other site 701177014239 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 701177014240 D-subunit interface [polypeptide binding]; other site 701177014241 Iron-sulfur protein interface; other site 701177014242 proximal quinone binding site [chemical binding]; other site 701177014243 distal quinone binding site [chemical binding]; other site 701177014244 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 701177014245 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 701177014246 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 701177014247 L-aspartate oxidase; Provisional; Region: PRK06175 701177014248 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 701177014249 poxB regulator PoxA; Provisional; Region: PRK09350 701177014250 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 701177014251 motif 1; other site 701177014252 dimer interface [polypeptide binding]; other site 701177014253 active site 701177014254 motif 2; other site 701177014255 motif 3; other site 701177014256 inner membrane transporter YjeM; Provisional; Region: PRK15238 701177014257 putative mechanosensitive channel protein; Provisional; Region: PRK10929 701177014258 linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated...; Region: H15; cl00073 701177014259 DNA-binding site [nucleotide binding]; DNA binding site 701177014260 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 701177014261 Mechanosensitive ion channel; Region: MS_channel; pfam00924 701177014262 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 701177014263 GTPase RsgA; Reviewed; Region: PRK12288 701177014264 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 701177014265 RNA binding site [nucleotide binding]; other site 701177014266 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 701177014267 GTPase/Zn-binding domain interface [polypeptide binding]; other site 701177014268 GTP/Mg2+ binding site [chemical binding]; other site 701177014269 G4 box; other site 701177014270 G5 box; other site 701177014271 G1 box; other site 701177014272 Switch I region; other site 701177014273 G2 box; other site 701177014274 G3 box; other site 701177014275 Switch II region; other site 701177014276 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 701177014277 catalytic site [active] 701177014278 putative active site [active] 701177014279 putative substrate binding site [chemical binding]; other site 701177014280 dimer interface [polypeptide binding]; other site 701177014281 epoxyqueuosine reductase; Region: TIGR00276 701177014282 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 701177014283 putative carbohydrate kinase; Provisional; Region: PRK10565 701177014284 yjeF N-terminal region; Region: yjeF_nterm; TIGR00197 701177014285 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 701177014286 putative substrate binding site [chemical binding]; other site 701177014287 putative ATP binding site [chemical binding]; other site 701177014288 ADP-binding protein; Provisional; Region: PRK10646 701177014289 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 701177014290 AMIN domain; Region: AMIN; pfam11741 701177014291 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 701177014292 active site 701177014293 metal binding site [ion binding]; metal-binding site 701177014294 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 701177014295 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 701177014296 ATP binding site [chemical binding]; other site 701177014297 Mg2+ binding site [ion binding]; other site 701177014298 G-X-G motif; other site 701177014299 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 701177014300 ATP binding site [chemical binding]; other site 701177014301 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 701177014302 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 701177014303 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 701177014304 bacterial Hfq-like; Region: Hfq; cd01716 701177014305 hexamer interface [polypeptide binding]; other site 701177014306 Sm1 motif; other site 701177014307 RNA binding site [nucleotide binding]; other site 701177014308 Sm2 motif; other site 701177014309 GTPase HflX; Provisional; Region: PRK11058 701177014310 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 701177014311 HflX GTPase family; Region: HflX; cd01878 701177014312 G1 box; other site 701177014313 GTP/Mg2+ binding site [chemical binding]; other site 701177014314 Switch I region; other site 701177014315 G2 box; other site 701177014316 G3 box; other site 701177014317 Switch II region; other site 701177014318 G4 box; other site 701177014319 G5 box; other site 701177014320 FtsH protease regulator HflK; Provisional; Region: PRK10930 701177014321 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 701177014322 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 701177014323 FtsH protease regulator HflC; Provisional; Region: PRK11029 701177014324 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 701177014325 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 701177014326 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 701177014327 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 701177014328 GDP-binding site [chemical binding]; other site 701177014329 ACT binding site; other site 701177014330 IMP binding site; other site 701177014331 Predicted transcriptional regulator [Transcription]; Region: COG1959 701177014332 transcriptional repressor NsrR; Provisional; Region: PRK11014 701177014333 exoribonuclease R; Provisional; Region: PRK11642 701177014334 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 701177014335 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 701177014336 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 701177014337 RNB domain; Region: RNB; pfam00773 701177014338 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 701177014339 RNA binding site [nucleotide binding]; other site 701177014340 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 701177014341 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 701177014342 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 701177014343 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3789 701177014344 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 701177014345 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 701177014346 Predicted membrane protein [Function unknown]; Region: COG3766 701177014347 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 701177014348 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 701177014349 Predicted integral membrane protein [Function unknown]; Region: COG5463 701177014350 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 701177014351 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 701177014352 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 701177014353 FAD binding site [chemical binding]; other site 701177014354 substrate binding site [chemical binding]; other site 701177014355 catalytic residues [active] 701177014356 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 701177014357 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 701177014358 esterase; Provisional; Region: PRK10566 701177014359 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 701177014360 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 701177014361 transcriptional repressor UlaR; Provisional; Region: PRK13509 701177014362 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 701177014363 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 701177014364 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 701177014365 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 701177014366 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 701177014367 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 701177014368 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 701177014369 active site 701177014370 P-loop; other site 701177014371 phosphorylation site [posttranslational modification] 701177014372 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 701177014373 active site 701177014374 phosphorylation site [posttranslational modification] 701177014375 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 701177014376 active site 701177014377 dimer interface [polypeptide binding]; other site 701177014378 magnesium binding site [ion binding]; other site 701177014379 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 701177014380 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 701177014381 AP (apurinic/apyrimidinic) site pocket; other site 701177014382 DNA interaction; other site 701177014383 Metal-binding active site; metal-binding site 701177014384 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 701177014385 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 701177014386 intersubunit interface [polypeptide binding]; other site 701177014387 active site 701177014388 Zn2+ binding site [ion binding]; other site 701177014389 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 701177014390 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 701177014391 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 701177014392 dimer interface [polypeptide binding]; other site 701177014393 ssDNA binding site [nucleotide binding]; other site 701177014394 tetramer (dimer of dimers) interface [polypeptide binding]; other site 701177014395 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 701177014396 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 701177014397 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 701177014398 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 701177014399 Protein of unknown function (DUF2686); Region: DUF2686; pfam10887 701177014400 Transposase IS200 like; Region: Y1_Tnp; pfam01797 701177014401 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 701177014402 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 701177014403 Probable transposase; Region: OrfB_IS605; pfam01385 701177014404 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 701177014405 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 701177014406 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 701177014407 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 701177014408 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 701177014409 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 701177014410 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 701177014411 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 701177014412 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 701177014413 Hemerythrin-like domain; Region: Hr-like; cd12108 701177014414 Fe binding site [ion binding]; other site 701177014415 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 701177014416 EamA-like transporter family; Region: EamA; pfam00892 701177014417 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 701177014418 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 701177014419 NADP binding site [chemical binding]; other site 701177014420 Predicted transcriptional regulators [Transcription]; Region: COG1733 701177014421 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 701177014422 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 701177014423 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 701177014424 active site 701177014425 metal binding site [ion binding]; metal-binding site 701177014426 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 701177014427 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 701177014428 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 701177014429 active site 701177014430 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 701177014431 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 701177014432 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 701177014433 Domain of unknown function DUF21; Region: DUF21; pfam01595 701177014434 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 701177014435 Transporter associated domain; Region: CorC_HlyC; smart01091 701177014436 methionine sulfoxide reductase A; Provisional; Region: PRK00058 701177014437 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 701177014438 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 701177014439 Surface antigen; Region: Bac_surface_Ag; pfam01103 701177014440 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 701177014441 Family of unknown function (DUF490); Region: DUF490; pfam04357 701177014442 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 701177014443 putative active site pocket [active] 701177014444 dimerization interface [polypeptide binding]; other site 701177014445 putative catalytic residue [active] 701177014446 hypothetical protein; Provisional; Region: PRK09719 701177014447 antitoxin ChpS; Provisional; Region: PRK11347 701177014448 toxin ChpB; Provisional; Region: PRK09812 701177014449 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 701177014450 dimer interface [polypeptide binding]; other site 701177014451 substrate binding site [chemical binding]; other site 701177014452 metal binding sites [ion binding]; metal-binding site 701177014453 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 701177014454 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 701177014455 putative ligand binding site [chemical binding]; other site 701177014456 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 701177014457 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 701177014458 Walker A/P-loop; other site 701177014459 ATP binding site [chemical binding]; other site 701177014460 Q-loop/lid; other site 701177014461 ABC transporter signature motif; other site 701177014462 Walker B; other site 701177014463 D-loop; other site 701177014464 H-loop/switch region; other site 701177014465 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 701177014466 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 701177014467 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 701177014468 TM-ABC transporter signature motif; other site 701177014469 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 701177014470 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 701177014471 TM-ABC transporter signature motif; other site 701177014472 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 701177014473 AMP binding site [chemical binding]; other site 701177014474 metal binding site [ion binding]; metal-binding site 701177014475 active site 701177014476 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 701177014477 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 701177014478 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 701177014479 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 701177014480 hypothetical protein; Provisional; Region: PRK05255 701177014481 peptidase PmbA; Provisional; Region: PRK11040 701177014482 Cytochrome b562; Region: Cytochrom_B562; cl01546 701177014483 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 701177014484 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 701177014485 FeS/SAM binding site; other site 701177014486 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 701177014487 ATP cone domain; Region: ATP-cone; pfam03477 701177014488 Class III ribonucleotide reductase; Region: RNR_III; cd01675 701177014489 effector binding site; other site 701177014490 active site 701177014491 Zn binding site [ion binding]; other site 701177014492 glycine loop; other site 701177014493 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 701177014494 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 701177014495 Ca binding site [ion binding]; other site 701177014496 active site 701177014497 catalytic site [active] 701177014498 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 701177014499 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 701177014500 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 701177014501 active site turn [active] 701177014502 phosphorylation site [posttranslational modification] 701177014503 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 701177014504 trehalose repressor; Provisional; Region: treR; PRK09492 701177014505 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 701177014506 DNA binding site [nucleotide binding] 701177014507 domain linker motif; other site 701177014508 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 701177014509 dimerization interface [polypeptide binding]; other site 701177014510 ligand binding site [chemical binding]; other site 701177014511 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 701177014512 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 701177014513 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 701177014514 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 701177014515 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 701177014516 motif II; other site 701177014517 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 701177014518 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 701177014519 homotrimer interaction site [polypeptide binding]; other site 701177014520 putative active site [active] 701177014521 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 701177014522 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 701177014523 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 701177014524 aspartate carbamoyltransferase; Region: asp_carb_tr; TIGR00670 701177014525 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 701177014526 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 701177014527 PyrBI operon leader peptide; Region: PyrBI_leader; pfam08052 701177014528 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 701177014529 homotrimer interaction site [polypeptide binding]; other site 701177014530 putative active site [active] 701177014531 oxidoreductase; Provisional; Region: PRK12742 701177014532 classical (c) SDRs; Region: SDR_c; cd05233 701177014533 NAD(P) binding site [chemical binding]; other site 701177014534 active site 701177014535 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 701177014536 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 701177014537 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 701177014538 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 701177014539 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 701177014540 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 701177014541 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076 701177014542 RNase E inhibitor protein; Provisional; Region: PRK11191 701177014543 Predicted membrane protein [Function unknown]; Region: COG4269 701177014544 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 701177014545 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 701177014546 HIGH motif; other site 701177014547 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 701177014548 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 701177014549 active site 701177014550 KMSKS motif; other site 701177014551 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 701177014552 tRNA binding surface [nucleotide binding]; other site 701177014553 anticodon binding site; other site 701177014554 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 701177014555 DNA polymerase III subunit chi; Validated; Region: PRK05728 701177014556 multifunctional aminopeptidase A; Provisional; Region: PRK00913 701177014557 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 701177014558 interface (dimer of trimers) [polypeptide binding]; other site 701177014559 Substrate-binding/catalytic site; other site 701177014560 Zn-binding sites [ion binding]; other site 701177014561 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 701177014562 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 701177014563 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 701177014564 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 701177014565 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 701177014566 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 701177014567 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 701177014568 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 701177014569 putative NAD(P) binding site [chemical binding]; other site 701177014570 putative substrate binding site [chemical binding]; other site 701177014571 catalytic Zn binding site [ion binding]; other site 701177014572 structural Zn binding site [ion binding]; other site 701177014573 dimer interface [polypeptide binding]; other site 701177014574 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 701177014575 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 701177014576 HNH endonuclease; Region: HNH_2; pfam13391 701177014577 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3055 701177014578 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 701177014579 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 701177014580 active site 701177014581 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 701177014582 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 701177014583 ligand binding site [chemical binding]; other site 701177014584 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 701177014585 Capsid triplex subunit 2; Provisional; Region: PHA03259 701177014586 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 701177014587 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 701177014588 ATP binding site [chemical binding]; other site 701177014589 putative Mg++ binding site [ion binding]; other site 701177014590 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 701177014591 nucleotide binding region [chemical binding]; other site 701177014592 ATP-binding site [chemical binding]; other site 701177014593 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 701177014594 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 701177014595 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 701177014596 ATP binding site [chemical binding]; other site 701177014597 putative Mg++ binding site [ion binding]; other site 701177014598 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 701177014599 nucleotide binding region [chemical binding]; other site 701177014600 ATP-binding site [chemical binding]; other site 701177014601 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 701177014602 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 701177014603 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 701177014604 ATP binding site [chemical binding]; other site 701177014605 putative Mg++ binding site [ion binding]; other site 701177014606 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 701177014607 ATP-binding site [chemical binding]; other site 701177014608 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 701177014609 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 701177014610 Part of AAA domain; Region: AAA_19; pfam13245 701177014611 Family description; Region: UvrD_C_2; pfam13538 701177014612 Domain of unknown function (DUF303); Region: DUF303; pfam03629 701177014613 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 701177014614 Kelch motif; Region: Kelch_1; pfam01344 701177014615 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 701177014616 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 701177014617 Int/Topo IB signature motif; other site 701177014618 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 701177014619 Int/Topo IB signature motif; other site 701177014620 Fimbrial protein; Region: Fimbrial; cl01416 701177014621 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 701177014622 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 701177014623 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 701177014624 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 701177014625 outer membrane usher protein; Provisional; Region: PRK15193 701177014626 PapC N-terminal domain; Region: PapC_N; pfam13954 701177014627 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 701177014628 PapC C-terminal domain; Region: PapC_C; pfam13953 701177014629 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 701177014630 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 701177014631 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 701177014632 mannosyl binding site [chemical binding]; other site 701177014633 Fimbrial protein; Region: Fimbrial; pfam00419 701177014634 fructuronate transporter; Provisional; Region: PRK10034 701177014635 gluconate transporter; Region: gntP; TIGR00791 701177014636 mannonate dehydratase; Region: uxuA; TIGR00695 701177014637 mannonate dehydratase; Provisional; Region: PRK03906 701177014638 D-mannonate oxidoreductase; Provisional; Region: PRK15037 701177014639 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 701177014640 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 701177014641 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 701177014642 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 701177014643 DNA-binding site [nucleotide binding]; DNA binding site 701177014644 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 701177014645 Protein of unknown function (DUF2686); Region: DUF2686; pfam10887 701177014646 DNA replication/recombination/repair protein; Provisional; Region: iraD; PRK14128 701177014647 cell density-dependent motility repressor; Provisional; Region: PRK10082 701177014648 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 701177014649 Isoaspartyl dipeptidase hydrolyzes the beta-L-isoaspartyl linkages in dipeptides, as part of the degradative pathway to eliminate proteins with beta-L-isoaspartyl peptide bonds, bonds whereby the beta-group of an aspartate forms the peptide link with the...; Region: Isoaspartyl-dipeptidase; cd01308 701177014650 isoaspartyl dipeptidase IadA; Region: isoAsp_dipep; TIGR01975 701177014651 dimer interface [polypeptide binding]; other site 701177014652 active site 701177014653 hypothetical protein; Provisional; Region: PRK10519 701177014654 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 701177014655 Nucleoside recognition; Region: Gate; pfam07670 701177014656 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 701177014657 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 701177014658 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 701177014659 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 701177014660 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 701177014661 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 701177014662 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 701177014663 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 701177014664 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 701177014665 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 701177014666 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 701177014667 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 701177014668 Major Facilitator Superfamily; Region: MFS_1; pfam07690 701177014669 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177014670 putative substrate translocation pore; other site 701177014671 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204 701177014672 SdiA-regulated; Region: SdiA-regulated; cd09971 701177014673 putative active site [active] 701177014674 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 701177014675 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 701177014676 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 701177014677 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 701177014678 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 701177014679 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 701177014680 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 701177014681 CoA-substrate-specific enzyme activase, putative; Region: CoA_E_activ; TIGR00241 701177014682 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 701177014683 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 701177014684 Predicted membrane protein [Function unknown]; Region: COG2733 701177014685 multidrug efflux system protein MdtM; Provisional; Region: PRK15403 701177014686 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177014687 putative substrate translocation pore; other site 701177014688 putative transposase; Provisional; Region: PRK09857 701177014689 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 701177014690 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 701177014691 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 701177014692 DNA-binding site [nucleotide binding]; DNA binding site 701177014693 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 701177014694 pyridoxal 5'-phosphate binding site [chemical binding]; other site 701177014695 homodimer interface [polypeptide binding]; other site 701177014696 catalytic residue [active] 701177014697 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 701177014698 endoribonuclease SymE; Provisional; Region: PRK13605 701177014699 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 701177014700 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 701177014701 HsdM N-terminal domain; Region: HsdM_N; pfam12161 701177014702 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 701177014703 Methyltransferase domain; Region: Methyltransf_26; pfam13659 701177014704 S-adenosylmethionine binding site [chemical binding]; other site 701177014705 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 701177014706 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 701177014707 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 701177014708 ATP binding site [chemical binding]; other site 701177014709 putative Mg++ binding site [ion binding]; other site 701177014710 Uncharacterized conserved protein [Function unknown]; Region: COG1479 701177014711 Protein of unknown function DUF262; Region: DUF262; pfam03235 701177014712 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 701177014713 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 701177014714 P-loop, Walker A motif; other site 701177014715 Base recognition motif; other site 701177014716 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 701177014717 Uncharacterized small protein [Function unknown]; Region: COG2879 701177014718 carbon starvation protein A; Provisional; Region: PRK15015 701177014719 Carbon starvation protein CstA; Region: CstA; pfam02554 701177014720 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 701177014721 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 701177014722 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 701177014723 dimer interface [polypeptide binding]; other site 701177014724 ligand binding site [chemical binding]; other site 701177014725 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 701177014726 dimerization interface [polypeptide binding]; other site 701177014727 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 701177014728 dimer interface [polypeptide binding]; other site 701177014729 putative CheW interface [polypeptide binding]; other site 701177014730 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 701177014731 D-galactonate transporter; Region: 2A0114; TIGR00893 701177014732 putative substrate translocation pore; other site 701177014733 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 701177014734 DNA-binding site [nucleotide binding]; DNA binding site 701177014735 Transcriptional regulators [Transcription]; Region: GntR; COG1802 701177014736 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 701177014737 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 701177014738 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 701177014739 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 701177014740 putative NAD(P) binding site [chemical binding]; other site 701177014741 catalytic Zn binding site [ion binding]; other site 701177014742 structural Zn binding site [ion binding]; other site 701177014743 phosphoglycerol transferase I; Provisional; Region: PRK03776 701177014744 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 701177014745 hypothetical protein; Provisional; Region: PRK11667 701177014746 DNA replication protein DnaC; Validated; Region: PRK07952 701177014747 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 701177014748 Walker A motif; other site 701177014749 ATP binding site [chemical binding]; other site 701177014750 Walker B motif; other site 701177014751 primosomal protein DnaI; Provisional; Region: PRK02854 701177014752 hypothetical protein; Provisional; Region: PRK09917 701177014753 Uncharacterized conserved protein [Function unknown]; Region: COG2966 701177014754 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 701177014755 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 701177014756 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 701177014757 DNA binding residues [nucleotide binding] 701177014758 dimerization interface [polypeptide binding]; other site 701177014759 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 701177014760 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 701177014761 DNA binding residues [nucleotide binding] 701177014762 dimerization interface [polypeptide binding]; other site 701177014763 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 701177014764 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 701177014765 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 701177014766 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 701177014767 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 701177014768 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 701177014769 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 701177014770 S-adenosylmethionine binding site [chemical binding]; other site 701177014771 DNA polymerase III subunit psi; Validated; Region: PRK06856 701177014772 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 701177014773 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 701177014774 Coenzyme A binding pocket [chemical binding]; other site 701177014775 dUMP phosphatase; Provisional; Region: PRK09449 701177014776 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 701177014777 motif II; other site 701177014778 integrase; Provisional; Region: PRK09692 701177014779 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 701177014780 active site 701177014781 Int/Topo IB signature motif; other site 701177014782 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 701177014783 Protein of unknown function (DUF551); Region: DUF551; pfam04448 701177014784 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 701177014785 Uncharacterized conserved protein [Function unknown]; Region: COG5532 701177014786 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 701177014787 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 701177014788 sequence-specific DNA binding site [nucleotide binding]; other site 701177014789 salt bridge; other site 701177014790 Predicted transcriptional regulator [Transcription]; Region: COG2932 701177014791 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 701177014792 Catalytic site [active] 701177014793 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 701177014794 non-specific DNA binding site [nucleotide binding]; other site 701177014795 salt bridge; other site 701177014796 sequence-specific DNA binding site [nucleotide binding]; other site 701177014797 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 701177014798 DNA-binding site [nucleotide binding]; DNA binding site 701177014799 PerC transcriptional activator; Region: PerC; pfam06069 701177014800 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; pfam05869 701177014801 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 701177014802 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 701177014803 KilA-N domain; Region: KilA-N; pfam04383 701177014804 Protein of unknown function (DUF968); Region: DUF968; pfam06147 701177014805 Antitermination protein; Region: Antiterm; pfam03589 701177014806 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 701177014807 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 701177014808 Zn binding sites [ion binding]; other site 701177014809 Antitermination protein; Region: Antiterm; pfam03589 701177014810 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 701177014811 DNA-binding site [nucleotide binding]; DNA binding site 701177014812 RNA-binding motif; other site 701177014813 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 701177014814 DNA-binding site [nucleotide binding]; DNA binding site 701177014815 RNA-binding motif; other site 701177014816 Lysis protein S; Region: Lysis_S; pfam04971 701177014817 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 701177014818 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 701177014819 catalytic residues [active] 701177014820 Protein of unknown function (DUF2514); Region: DUF2514; pfam10721 701177014821 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 701177014822 DNA-binding site [nucleotide binding]; DNA binding site 701177014823 RNA-binding motif; other site 701177014824 GnsA/GnsB family; Region: GnsAB; pfam08178 701177014825 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 701177014826 Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471 701177014827 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 701177014828 gpW; Region: gpW; pfam02831 701177014829 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 701177014830 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 701177014831 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 701177014832 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 701177014833 tandem repeat interface [polypeptide binding]; other site 701177014834 oligomer interface [polypeptide binding]; other site 701177014835 active site residues [active] 701177014836 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 701177014837 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 701177014838 DNA packaging protein FI; Region: Packaging_FI; pfam14000 701177014839 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 701177014840 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 701177014841 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 701177014842 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 701177014843 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 701177014844 phage minor tail protein G; Region: phage_lambda_G; TIGR01674 701177014845 Minor tail protein T; Region: Phage_tail_T; pfam06223 701177014846 Phage-related minor tail protein [Function unknown]; Region: COG5281 701177014847 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 701177014848 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 701177014849 Phage-related protein [Function unknown]; Region: COG4718 701177014850 Phage-related protein [Function unknown]; Region: gp18; COG4672 701177014851 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 701177014852 MPN+ (JAMM) motif; other site 701177014853 Zinc-binding site [ion binding]; other site 701177014854 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 701177014855 NlpC/P60 family; Region: NLPC_P60; cl17555 701177014856 Phage-related protein, tail component [Function unknown]; Region: COG4723 701177014857 Phage-related protein, tail component [Function unknown]; Region: COG4733 701177014858 Putative phage tail protein; Region: Phage-tail_3; pfam13550 701177014859 Fibronectin type 3 domain; Region: FN3; smart00060 701177014860 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 701177014861 Fibronectin type III protein; Region: DUF3672; pfam12421 701177014862 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 701177014863 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 701177014864 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 701177014865 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 701177014866 Phage Tail Collar Domain; Region: Collar; pfam07484 701177014867 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 701177014868 multiple promoter invertase; Provisional; Region: mpi; PRK13413 701177014869 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 701177014870 catalytic residues [active] 701177014871 catalytic nucleophile [active] 701177014872 Presynaptic Site I dimer interface [polypeptide binding]; other site 701177014873 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 701177014874 Synaptic Flat tetramer interface [polypeptide binding]; other site 701177014875 Synaptic Site I dimer interface [polypeptide binding]; other site 701177014876 DNA binding site [nucleotide binding] 701177014877 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 701177014878 DNA-binding interface [nucleotide binding]; DNA binding site 701177014879 DinI-like family; Region: DinI; pfam06183 701177014880 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 701177014881 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 701177014882 G1 box; other site 701177014883 putative GEF interaction site [polypeptide binding]; other site 701177014884 GTP/Mg2+ binding site [chemical binding]; other site 701177014885 Switch I region; other site 701177014886 G2 box; other site 701177014887 G3 box; other site 701177014888 Switch II region; other site 701177014889 G4 box; other site 701177014890 G5 box; other site 701177014891 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 701177014892 periplasmic protein; Provisional; Region: PRK10568 701177014893 BON domain; Region: BON; pfam04972 701177014894 BON domain; Region: BON; pfam04972 701177014895 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 701177014896 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 701177014897 active site 701177014898 nucleophile elbow; other site 701177014899 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 701177014900 active site 701177014901 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 701177014902 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 701177014903 FeS/SAM binding site; other site 701177014904 hypothetical protein; Provisional; Region: PRK10977 701177014905 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 701177014906 intersubunit interface [polypeptide binding]; other site 701177014907 active site 701177014908 catalytic residue [active] 701177014909 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 701177014910 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 701177014911 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 701177014912 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 701177014913 phosphopentomutase; Provisional; Region: PRK05362 701177014914 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 701177014915 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 701177014916 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 701177014917 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 701177014918 non-specific DNA binding site [nucleotide binding]; other site 701177014919 salt bridge; other site 701177014920 sequence-specific DNA binding site [nucleotide binding]; other site 701177014921 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 701177014922 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 701177014923 motif II; other site 701177014924 DNA repair protein RadA; Region: sms; TIGR00416 701177014925 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 701177014926 Walker A motif/ATP binding site; other site 701177014927 ATP binding site [chemical binding]; other site 701177014928 Walker B motif; other site 701177014929 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 701177014930 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 701177014931 non-specific DNA binding site [nucleotide binding]; other site 701177014932 salt bridge; other site 701177014933 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 701177014934 sequence-specific DNA binding site [nucleotide binding]; other site 701177014935 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 701177014936 active site 701177014937 (T/H)XGH motif; other site 701177014938 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 701177014939 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 701177014940 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 701177014941 Walker A/P-loop; other site 701177014942 ATP binding site [chemical binding]; other site 701177014943 Q-loop/lid; other site 701177014944 ABC transporter signature motif; other site 701177014945 Walker B; other site 701177014946 D-loop; other site 701177014947 H-loop/switch region; other site 701177014948 ABC transporter; Region: ABC_tran_2; pfam12848 701177014949 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 701177014950 lytic murein transglycosylase; Provisional; Region: PRK11619 701177014951 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 701177014952 N-acetyl-D-glucosamine binding site [chemical binding]; other site 701177014953 catalytic residue [active] 701177014954 Trp operon repressor; Provisional; Region: PRK01381 701177014955 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 701177014956 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 701177014957 catalytic core [active] 701177014958 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 701177014959 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 701177014960 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 701177014961 hypothetical protein; Provisional; Region: PRK10756 701177014962 CreA protein; Region: CreA; pfam05981 701177014963 DNA-binding response regulator CreB; Provisional; Region: PRK11083 701177014964 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 701177014965 active site 701177014966 phosphorylation site [posttranslational modification] 701177014967 intermolecular recognition site; other site 701177014968 dimerization interface [polypeptide binding]; other site 701177014969 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 701177014970 DNA binding site [nucleotide binding] 701177014971 sensory histidine kinase CreC; Provisional; Region: PRK11100 701177014972 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 701177014973 dimerization interface [polypeptide binding]; other site 701177014974 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 701177014975 dimer interface [polypeptide binding]; other site 701177014976 phosphorylation site [posttranslational modification] 701177014977 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 701177014978 ATP binding site [chemical binding]; other site 701177014979 Mg2+ binding site [ion binding]; other site 701177014980 G-X-G motif; other site 701177014981 Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452 701177014982 two-component response regulator; Provisional; Region: PRK11173 701177014983 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 701177014984 active site 701177014985 phosphorylation site [posttranslational modification] 701177014986 intermolecular recognition site; other site 701177014987 dimerization interface [polypeptide binding]; other site 701177014988 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 701177014989 DNA binding site [nucleotide binding] 701177014990 putative RNA methyltransferase; Provisional; Region: PRK10433 701177014991 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050 701177014992 Antirestriction protein; Region: Antirestrict; pfam03230 701177014993 Protein of unknown function (DUF1380); Region: DUF1380; pfam07128 701177014994 Domain of unknown function (DUF932); Region: DUF932; pfam06067 701177014995 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 701177014996 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 701177014997 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 701177014998 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 701177014999 N-acetyl-D-glucosamine binding site [chemical binding]; other site 701177015000 catalytic residue [active] 701177015001 TraM protein; Region: Tra_M; pfam05261 701177015002 conjugal transfer transcriptional regulator TraJ; Provisional; Region: PRK13719 701177015003 conjugal transfer protein TraY; Provisional; Region: PRK13740 701177015004 TraY domain; Region: TraY; cl17675 701177015005 conjugal transfer pilin subunit TraA; Provisional; Region: PRK13734 701177015006 conjugal transfer pilus assembly protein TraL; Provisional; Region: PRK13707 701177015007 conjugal transfer pilus assembly protein TraE; Provisional; Region: PRK13726 701177015008 conjugal transfer protein TraK; Provisional; Region: PRK13736; cl05878 701177015009 TraK protein; Region: TraK; pfam06586 701177015010 conjugal transfer nickase/helicase TraI; Provisional; Region: PRK14712 701177015011 conjugal transfer nickase/helicase TraI; Provisional; Region: PRK14712 701177015012 conjugal transfer pilus acetylation protein TraX; Provisional; Region: PRK13706 701177015013 conjugal transfer protein TrbP; Provisional; Region: PRK13882 701177015014 conjugal transfer fertility inhibition protein FinO; Provisional; Region: PRK13754 701177015015 Fertility inhibition protein N terminal; Region: FinO_N; pfam12602 701177015016 FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cd00236 701177015017 putative RNA binding sites [nucleotide binding]; other site 701177015018 Staphylococcal nuclease homologues; Region: SNc; smart00318 701177015019 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 701177015020 Catalytic site; other site 701177015021 Integrase core domain; Region: rve; pfam00665 701177015022 Peptidase M66; Region: Peptidase_M66; pfam10462 701177015023 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 701177015024 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 701177015025 type II secretion system protein D; Region: type_II_gspD; TIGR02517 701177015026 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 701177015027 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 701177015028 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 701177015029 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 701177015030 type II secretion system protein E; Region: type_II_gspE; TIGR02533 701177015031 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 701177015032 Walker A motif; other site 701177015033 ATP binding site [chemical binding]; other site 701177015034 Walker B motif; other site 701177015035 type II secretion system protein F; Region: GspF; TIGR02120 701177015036 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 701177015037 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 701177015038 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 701177015039 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 701177015040 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 701177015041 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 701177015042 type II secretion system protein I; Region: gspI; TIGR01707 701177015043 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 701177015044 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 701177015045 type II secretion system protein J; Region: gspJ; TIGR01711 701177015046 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 701177015047 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 701177015048 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 701177015049 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 701177015050 GspL periplasmic domain; Region: GspL_C; pfam12693 701177015051 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 701177015052 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 701177015053 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 701177015054 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 701177015055 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 701177015056 Transposase; Region: DEDD_Tnp_IS110; pfam01548 701177015057 replication protein; Provisional; Region: PRK13702 701177015058 RelB antitoxin; Region: RelB; cl01171 701177015059 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 701177015060 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 701177015061 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 701177015062 trimer interface [polypeptide binding]; other site 701177015063 active site 701177015064 substrate binding site [chemical binding]; other site 701177015065 CoA binding site [chemical binding]; other site 701177015066 FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cd00236 701177015067 putative kissing complex interaction region; other site 701177015068 putative RNA binding sites [nucleotide binding]; other site 701177015069 Colicin Ia; Region: Colicin_Ia; pfam11504 701177015070 Colicin pore forming domain; Region: Colicin; pfam01024 701177015071 Colicin E1 (microcin) immunity protein; Region: Microcin; pfam03526 701177015072 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 701177015073 Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient...; Region: SR_Res_par; cd03767 701177015074 catalytic residues [active] 701177015075 catalytic nucleophile [active] 701177015076 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 701177015077 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 701177015078 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 701177015079 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 701177015080 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 701177015081 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 701177015082 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 701177015083 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 701177015084 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 701177015085 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 701177015086 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 701177015087 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 701177015088 salt bridge; other site 701177015089 non-specific DNA binding site [nucleotide binding]; other site 701177015090 sequence-specific DNA binding site [nucleotide binding]; other site 701177015091 Integrase core domain; Region: rve; pfam00665 701177015092 putative transposase OrfB; Reviewed; Region: PHA02517 701177015093 HTH-like domain; Region: HTH_21; pfam13276 701177015094 Integrase core domain; Region: rve; pfam00665 701177015095 Integrase core domain; Region: rve_3; pfam13683 701177015096 Transposase; Region: HTH_Tnp_1; cl17663 701177015097 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 701177015098 3-deoxy-D-manno-octulosonic-acid kinase; Reviewed; Region: PRK01723 701177015099 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 701177015100 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 701177015101 active site 701177015102 catalytic residues [active] 701177015103 DNA binding site [nucleotide binding] 701177015104 Int/Topo IB signature motif; other site 701177015105 Integrase core domain; Region: rve; pfam00665 701177015106 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 701177015107 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 701177015108 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 701177015109 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 701177015110 P-loop; other site 701177015111 Magnesium ion binding site [ion binding]; other site 701177015112 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 701177015113 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 701177015114 ParB-like nuclease domain; Region: ParB; smart00470 701177015115 ParB family; Region: ParB; pfam08775 701177015116 Y-family of DNA polymerases; Region: PolY; cl12025 701177015117 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 701177015118 Y-family of DNA polymerases; Region: PolY; cl12025 701177015119 putative methylase; Provisional; Region: PRK13699 701177015120 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 701177015121 Protein of unknown function (DUF1380); Region: DUF1380; pfam07128