-- dump date 20140619_090245 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1048689000001 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 1048689000002 DNA binding site [nucleotide binding] 1048689000003 dimer interface [polypeptide binding]; other site 1048689000004 active site 1048689000005 Int/Topo IB signature motif; other site 1048689000006 potential frameshift: common BLAST hit: gi|188535877|ref|YP_001905937.1| Resolvase 1048689000007 potential frameshift: common BLAST hit: gi|291285906|ref|YP_003502723.1| resolvase 1048689000008 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1048689000009 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1048689000010 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1048689000011 conserved cys residue [active] 1048689000012 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1048689000013 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1048689000014 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1048689000015 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1048689000016 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1048689000017 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1048689000018 ATP-binding site [chemical binding]; other site 1048689000019 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1048689000020 catalytic residues [active] 1048689000021 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1048689000022 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1048689000023 dimer interface [polypeptide binding]; other site 1048689000024 ssDNA binding site [nucleotide binding]; other site 1048689000025 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1048689000026 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 1048689000027 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 1048689000028 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1048689000029 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1048689000030 catalytic residues [active] 1048689000031 catalytic nucleophile [active] 1048689000032 Presynaptic Site I dimer interface [polypeptide binding]; other site 1048689000033 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1048689000034 Synaptic Flat tetramer interface [polypeptide binding]; other site 1048689000035 Synaptic Site I dimer interface [polypeptide binding]; other site 1048689000036 DNA binding site [nucleotide binding] 1048689000037 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1048689000038 DNA-binding interface [nucleotide binding]; DNA binding site 1048689000039 Phage Tail Collar Domain; Region: Collar; pfam07484 1048689000040 Phage Tail Collar Domain; Region: Collar; pfam07484 1048689000041 Phage Tail Collar Domain; Region: Collar; pfam07484 1048689000042 Phage Tail Collar Domain; Region: Collar; pfam07484 1048689000043 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1048689000044 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 1048689000045 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 1048689000046 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 1048689000047 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 1048689000048 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 1048689000049 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 1048689000050 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 1048689000051 Phage Tail Collar Domain; Region: Collar; pfam07484 1048689000052 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 1048689000053 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1048689000054 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1048689000055 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1048689000056 catalytic residue [active] 1048689000057 ABC transporter C family member; Provisional; Region: PLN03130 1048689000058 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 1048689000059 KilA-N domain; Region: KilA-N; pfam04383 1048689000060 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 1048689000061 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 1048689000062 Hok/gef family; Region: HOK_GEF; pfam01848 1048689000063 ParB-like nuclease domain; Region: ParBc; pfam02195 1048689000064 ParB family; Region: ParB; pfam08775 1048689000065 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1048689000066 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1048689000067 P-loop; other site 1048689000068 Magnesium ion binding site [ion binding]; other site 1048689000069 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1048689000070 Magnesium ion binding site [ion binding]; other site 1048689000071 T5orf172 domain; Region: T5orf172; pfam10544 1048689000072 Putative exonuclease, RdgC; Region: RdgC; pfam04381 1048689000073 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1048689000074 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1048689000075 cofactor binding site; other site 1048689000076 DNA binding site [nucleotide binding] 1048689000077 substrate interaction site [chemical binding]; other site 1048689000078 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 1048689000079 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1048689000080 SPFH domain / Band 7 family; Region: Band_7; pfam01145 1048689000081 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1048689000082 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1048689000083 replicative DNA helicase; Provisional; Region: PRK08006 1048689000084 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1048689000085 Walker A motif; other site 1048689000086 ATP binding site [chemical binding]; other site 1048689000087 Walker B motif; other site 1048689000088 DNA binding loops [nucleotide binding] 1048689000089 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1048689000090 Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812 1048689000091 VRR-NUC domain; Region: VRR_NUC; pfam08774 1048689000092 Protein of unknown function DUF115; Region: MAF_flag10; cl17471 1048689000093 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 1048689000094 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1048689000095 active site 1048689000096 metal binding site [ion binding]; metal-binding site 1048689000097 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1048689000098 This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins; Region: LNS2; smart00775 1048689000099 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 1048689000100 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 1048689000101 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 1048689000102 basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins; Region: B_zip1; cl02576 1048689000103 DNA polymerase III, theta subunit; Region: DNA_pol3_theta; pfam06440 1048689000104 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1048689000105 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1048689000106 Catalytic site [active] 1048689000107 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1048689000108 death-on-curing family protein; Region: DOC_P1; TIGR01550 1048689000109 Protein of unknown function (DUF968); Region: DUF968; pfam06147 1048689000110 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1048689000111 beta-lactamase TEM; Provisional; Region: PRK15442 1048689000112 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1048689000113 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1048689000114 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1048689000115 catalytic residues [active] 1048689000116 catalytic nucleophile [active] 1048689000117 Presynaptic Site I dimer interface [polypeptide binding]; other site 1048689000118 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1048689000119 Synaptic Flat tetramer interface [polypeptide binding]; other site 1048689000120 Synaptic Site I dimer interface [polypeptide binding]; other site 1048689000121 DNA binding site [nucleotide binding] 1048689000122 Helix-turn-helix domain of resolvase; Region: HTH_7; pfam02796 1048689000123 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 1048689000124 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 1048689000125 stationary phase growth adaptation protein; Provisional; Region: PRK09717 1048689000126 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 1048689000127 Rop protein; Region: Rop; pfam01815 1048689000128 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 1048689000129 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 1048689000130 MbeB-like, N-term conserved region; Region: MbeB_N; pfam04837 1048689000131 MbeD/MobD like; Region: MbeD_MobD; pfam04899 1048689000132 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1048689000133 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1048689000134 cofactor binding site; other site 1048689000135 DNA binding site [nucleotide binding] 1048689000136 substrate interaction site [chemical binding]; other site 1048689000137 Rop protein; Region: Rop; pfam01815 1048689000138 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 1048689000139 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 1048689000140 MbeB-like, N-term conserved region; Region: MbeB_N; pfam04837 1048689000141 MbeD/MobD like; Region: MbeD_MobD; pfam04899 1048689000142 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 1048689000143 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 1048689000144 putative catalytic residues [active] 1048689000145 putative nucleotide binding site [chemical binding]; other site 1048689000146 putative aspartate binding site [chemical binding]; other site 1048689000147 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 1048689000148 dimer interface [polypeptide binding]; other site 1048689000149 putative threonine allosteric regulatory site; other site 1048689000150 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 1048689000151 putative threonine allosteric regulatory site; other site 1048689000152 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1048689000153 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1048689000154 homoserine kinase; Region: thrB; TIGR00191 1048689000155 Protein of unknown function; Region: YhfT; pfam10797 1048689000156 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1048689000157 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1048689000158 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1048689000159 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048689000160 catalytic residue [active] 1048689000161 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 1048689000162 hypothetical protein; Validated; Region: PRK02101 1048689000163 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1048689000164 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 1048689000165 transaldolase-like protein; Provisional; Region: PTZ00411 1048689000166 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1048689000167 active site 1048689000168 dimer interface [polypeptide binding]; other site 1048689000169 catalytic residue [active] 1048689000170 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1048689000171 MPT binding site; other site 1048689000172 trimer interface [polypeptide binding]; other site 1048689000173 hypothetical protein; Provisional; Region: PRK10659 1048689000174 hypothetical protein; Provisional; Region: PRK10236 1048689000175 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 1048689000176 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 1048689000177 hypothetical protein; Provisional; Region: PRK10154 1048689000178 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1048689000179 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 1048689000180 nucleotide binding site [chemical binding]; other site 1048689000181 NEF interaction site [polypeptide binding]; other site 1048689000182 SBD interface [polypeptide binding]; other site 1048689000183 chaperone protein DnaJ; Provisional; Region: PRK10767 1048689000184 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1048689000185 HSP70 interaction site [polypeptide binding]; other site 1048689000186 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1048689000187 substrate binding site [polypeptide binding]; other site 1048689000188 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1048689000189 Zn binding sites [ion binding]; other site 1048689000190 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1048689000191 dimer interface [polypeptide binding]; other site 1048689000192 Hok/gef family; Region: HOK_GEF; pfam01848 1048689000193 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 1048689000194 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 1048689000195 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1048689000196 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 1048689000197 putative dimerization interface [polypeptide binding]; other site 1048689000198 fimbrial outer membrane usher protein; Provisional; Region: PRK15217 1048689000199 PapC N-terminal domain; Region: PapC_N; pfam13954 1048689000200 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1048689000201 PapC C-terminal domain; Region: PapC_C; pfam13953 1048689000202 putative fimbrial assembly chaperone protein StcB; Provisional; Region: PRK15253 1048689000203 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1048689000204 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1048689000205 Fimbrial protein; Region: Fimbrial; cl01416 1048689000206 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1048689000207 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1048689000208 Protein of unknown function (DUF2575); Region: DUF2575; pfam10837 1048689000209 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1048689000210 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1048689000211 active site 1048689000212 Riboflavin kinase; Region: Flavokinase; smart00904 1048689000213 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1048689000214 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1048689000215 HIGH motif; other site 1048689000216 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1048689000217 active site 1048689000218 KMSKS motif; other site 1048689000219 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1048689000220 tRNA binding surface [nucleotide binding]; other site 1048689000221 anticodon binding site; other site 1048689000222 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1048689000223 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1048689000224 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 1048689000225 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1048689000226 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1048689000227 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1048689000228 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1048689000229 active site 1048689000230 tetramer interface [polypeptide binding]; other site 1048689000231 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 1048689000232 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1048689000233 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1048689000234 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1048689000235 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1048689000236 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1048689000237 catalytic site [active] 1048689000238 subunit interface [polypeptide binding]; other site 1048689000239 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1048689000240 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1048689000241 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1048689000242 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1048689000243 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1048689000244 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1048689000245 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1048689000246 IMP binding site; other site 1048689000247 dimer interface [polypeptide binding]; other site 1048689000248 interdomain contacts; other site 1048689000249 partial ornithine binding site; other site 1048689000250 DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476 1048689000251 carnitine operon protein CaiE; Provisional; Region: PRK13627 1048689000252 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 1048689000253 putative trimer interface [polypeptide binding]; other site 1048689000254 putative metal binding site [ion binding]; other site 1048689000255 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 1048689000256 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1048689000257 substrate binding site [chemical binding]; other site 1048689000258 oxyanion hole (OAH) forming residues; other site 1048689000259 trimer interface [polypeptide binding]; other site 1048689000260 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 1048689000261 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 1048689000262 acyl-activating enzyme (AAE) consensus motif; other site 1048689000263 putative AMP binding site [chemical binding]; other site 1048689000264 putative active site [active] 1048689000265 putative CoA binding site [chemical binding]; other site 1048689000266 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 1048689000267 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1048689000268 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 1048689000269 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1048689000270 active site 1048689000271 L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356 1048689000272 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1048689000273 Ligand binding site [chemical binding]; other site 1048689000274 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1048689000275 putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363 1048689000276 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985 1048689000277 Ligand binding site [chemical binding]; other site 1048689000278 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1048689000279 putative oxidoreductase FixC; Provisional; Region: PRK10157 1048689000280 ferredoxin-like protein FixX; Provisional; Region: PRK15449 1048689000281 benzoate transport; Region: 2A0115; TIGR00895 1048689000282 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689000283 putative substrate translocation pore; other site 1048689000284 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 1048689000285 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 1048689000286 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 1048689000287 TrkA-N domain; Region: TrkA_N; pfam02254 1048689000288 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1048689000289 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1048689000290 folate binding site [chemical binding]; other site 1048689000291 NADP+ binding site [chemical binding]; other site 1048689000292 Post-segregation antitoxin CcdA; Region: CcdA; pfam07362 1048689000293 CcdB protein; Region: CcdB; pfam01845 1048689000294 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 1048689000295 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 1048689000296 active site 1048689000297 metal binding site [ion binding]; metal-binding site 1048689000298 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 1048689000299 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1048689000300 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1048689000301 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 1048689000302 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1048689000303 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 1048689000304 SurA N-terminal domain; Region: SurA_N; pfam09312 1048689000305 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1048689000306 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1048689000307 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 1048689000308 OstA-like protein; Region: OstA; pfam03968 1048689000309 Organic solvent tolerance protein; Region: OstA_C; pfam04453 1048689000310 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 1048689000311 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 1048689000312 putative metal binding site [ion binding]; other site 1048689000313 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1048689000314 HSP70 interaction site [polypeptide binding]; other site 1048689000315 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1048689000316 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1048689000317 active site 1048689000318 ATP-dependent helicase HepA; Validated; Region: PRK04914 1048689000319 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1048689000320 ATP binding site [chemical binding]; other site 1048689000321 putative Mg++ binding site [ion binding]; other site 1048689000322 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1048689000323 nucleotide binding region [chemical binding]; other site 1048689000324 ATP-binding site [chemical binding]; other site 1048689000325 DNA polymerase II; Reviewed; Region: PRK05762 1048689000326 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 1048689000327 active site 1048689000328 catalytic site [active] 1048689000329 substrate binding site [chemical binding]; other site 1048689000330 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 1048689000331 active site 1048689000332 metal-binding site 1048689000333 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1048689000334 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1048689000335 intersubunit interface [polypeptide binding]; other site 1048689000336 active site 1048689000337 Zn2+ binding site [ion binding]; other site 1048689000338 L-arabinose isomerase; Provisional; Region: PRK02929 1048689000339 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 1048689000340 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 1048689000341 trimer interface [polypeptide binding]; other site 1048689000342 putative substrate binding site [chemical binding]; other site 1048689000343 putative metal binding site [ion binding]; other site 1048689000344 ribulokinase; Provisional; Region: PRK04123 1048689000345 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1048689000346 N- and C-terminal domain interface [polypeptide binding]; other site 1048689000347 active site 1048689000348 MgATP binding site [chemical binding]; other site 1048689000349 catalytic site [active] 1048689000350 metal binding site [ion binding]; metal-binding site 1048689000351 carbohydrate binding site [chemical binding]; other site 1048689000352 homodimer interface [polypeptide binding]; other site 1048689000353 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 1048689000354 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1048689000355 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1048689000356 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1048689000357 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1048689000358 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1048689000359 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 1048689000360 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 1048689000361 Walker A/P-loop; other site 1048689000362 ATP binding site [chemical binding]; other site 1048689000363 Q-loop/lid; other site 1048689000364 ABC transporter signature motif; other site 1048689000365 Walker B; other site 1048689000366 D-loop; other site 1048689000367 H-loop/switch region; other site 1048689000368 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 1048689000369 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048689000370 dimer interface [polypeptide binding]; other site 1048689000371 conserved gate region; other site 1048689000372 putative PBP binding loops; other site 1048689000373 ABC-ATPase subunit interface; other site 1048689000374 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048689000375 dimer interface [polypeptide binding]; other site 1048689000376 conserved gate region; other site 1048689000377 putative PBP binding loops; other site 1048689000378 ABC-ATPase subunit interface; other site 1048689000379 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 1048689000380 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 1048689000381 transcriptional regulator SgrR; Provisional; Region: PRK13626 1048689000382 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1048689000383 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 1048689000384 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1048689000385 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1048689000386 substrate binding site [chemical binding]; other site 1048689000387 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1048689000388 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1048689000389 substrate binding site [chemical binding]; other site 1048689000390 ligand binding site [chemical binding]; other site 1048689000391 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1048689000392 tartrate dehydrogenase; Region: TTC; TIGR02089 1048689000393 2-isopropylmalate synthase; Validated; Region: PRK00915 1048689000394 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1048689000395 active site 1048689000396 catalytic residues [active] 1048689000397 metal binding site [ion binding]; metal-binding site 1048689000398 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1048689000399 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 1048689000400 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1048689000401 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 1048689000402 putative substrate binding pocket [chemical binding]; other site 1048689000403 putative dimerization interface [polypeptide binding]; other site 1048689000404 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 1048689000405 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1048689000406 PYR/PP interface [polypeptide binding]; other site 1048689000407 dimer interface [polypeptide binding]; other site 1048689000408 TPP binding site [chemical binding]; other site 1048689000409 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1048689000410 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1048689000411 TPP-binding site [chemical binding]; other site 1048689000412 dimer interface [polypeptide binding]; other site 1048689000413 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1048689000414 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1048689000415 putative valine binding site [chemical binding]; other site 1048689000416 dimer interface [polypeptide binding]; other site 1048689000417 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1048689000418 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 1048689000419 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1048689000420 DNA binding site [nucleotide binding] 1048689000421 domain linker motif; other site 1048689000422 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 1048689000423 dimerization interface [polypeptide binding]; other site 1048689000424 ligand binding site [chemical binding]; other site 1048689000425 mraZ protein; Region: TIGR00242 1048689000426 MraZ protein; Region: MraZ; pfam02381 1048689000427 MraZ protein; Region: MraZ; pfam02381 1048689000428 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 1048689000429 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1048689000430 cell division protein FtsL; Provisional; Region: PRK10772 1048689000431 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 1048689000432 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1048689000433 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1048689000434 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1048689000435 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1048689000436 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1048689000437 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1048689000438 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 1048689000439 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1048689000440 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1048689000441 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1048689000442 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1048689000443 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1048689000444 Mg++ binding site [ion binding]; other site 1048689000445 putative catalytic motif [active] 1048689000446 putative substrate binding site [chemical binding]; other site 1048689000447 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 1048689000448 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1048689000449 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1048689000450 cell division protein FtsW; Provisional; Region: PRK10774 1048689000451 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1048689000452 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1048689000453 active site 1048689000454 homodimer interface [polypeptide binding]; other site 1048689000455 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1048689000456 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1048689000457 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1048689000458 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1048689000459 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1048689000460 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1048689000461 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1048689000462 cell division protein FtsQ; Provisional; Region: PRK10775 1048689000463 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1048689000464 Cell division protein FtsQ; Region: FtsQ; pfam03799 1048689000465 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 1048689000466 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1048689000467 Cell division protein FtsA; Region: FtsA; pfam14450 1048689000468 cell division protein FtsZ; Validated; Region: PRK09330 1048689000469 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1048689000470 nucleotide binding site [chemical binding]; other site 1048689000471 SulA interaction site; other site 1048689000472 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 1048689000473 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1048689000474 SecA regulator SecM; Provisional; Region: PRK02943 1048689000475 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1048689000476 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1048689000477 SEC-C motif; Region: SEC-C; pfam02810 1048689000478 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1048689000479 active site 1048689000480 8-oxo-dGMP binding site [chemical binding]; other site 1048689000481 nudix motif; other site 1048689000482 metal binding site [ion binding]; metal-binding site 1048689000483 DNA gyrase inhibitor; Reviewed; Region: PRK00418 1048689000484 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 1048689000485 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1048689000486 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1048689000487 CoA-binding site [chemical binding]; other site 1048689000488 ATP-binding [chemical binding]; other site 1048689000489 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 1048689000490 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1048689000491 active site 1048689000492 type IV pilin biogenesis protein; Provisional; Region: PRK10573 1048689000493 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1048689000494 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1048689000495 putative major pilin subunit; Provisional; Region: PRK10574 1048689000496 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1048689000497 Pilin (bacterial filament); Region: Pilin; pfam00114 1048689000498 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 1048689000499 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1048689000500 dimerization interface [polypeptide binding]; other site 1048689000501 active site 1048689000502 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1048689000503 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1048689000504 amidase catalytic site [active] 1048689000505 Zn binding residues [ion binding]; other site 1048689000506 substrate binding site [chemical binding]; other site 1048689000507 regulatory protein AmpE; Provisional; Region: PRK10987 1048689000508 aromatic amino acid transporter; Provisional; Region: PRK10238 1048689000509 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1048689000510 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1048689000511 DNA-binding site [nucleotide binding]; DNA binding site 1048689000512 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1048689000513 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1048689000514 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1048689000515 dimer interface [polypeptide binding]; other site 1048689000516 TPP-binding site [chemical binding]; other site 1048689000517 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 1048689000518 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1048689000519 E3 interaction surface; other site 1048689000520 lipoyl attachment site [posttranslational modification]; other site 1048689000521 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1048689000522 E3 interaction surface; other site 1048689000523 lipoyl attachment site [posttranslational modification]; other site 1048689000524 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1048689000525 E3 interaction surface; other site 1048689000526 lipoyl attachment site [posttranslational modification]; other site 1048689000527 e3 binding domain; Region: E3_binding; pfam02817 1048689000528 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1048689000529 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 1048689000530 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1048689000531 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1048689000532 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1048689000533 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 1048689000534 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 1048689000535 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 1048689000536 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 1048689000537 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 1048689000538 substrate binding site [chemical binding]; other site 1048689000539 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 1048689000540 substrate binding site [chemical binding]; other site 1048689000541 ligand binding site [chemical binding]; other site 1048689000542 hypothetical protein; Provisional; Region: PRK05248 1048689000543 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 1048689000544 spermidine synthase; Provisional; Region: PRK00811 1048689000545 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1048689000546 S-adenosylmethionine binding site [chemical binding]; other site 1048689000547 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 1048689000548 multicopper oxidase; Provisional; Region: PRK10965 1048689000549 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1048689000550 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1048689000551 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1048689000552 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 1048689000553 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 1048689000554 Trp docking motif [polypeptide binding]; other site 1048689000555 putative active site [active] 1048689000556 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1048689000557 active site 1048689000558 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 1048689000559 active site clefts [active] 1048689000560 zinc binding site [ion binding]; other site 1048689000561 dimer interface [polypeptide binding]; other site 1048689000562 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1048689000563 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1048689000564 Walker A/P-loop; other site 1048689000565 ATP binding site [chemical binding]; other site 1048689000566 Q-loop/lid; other site 1048689000567 ABC transporter signature motif; other site 1048689000568 Walker B; other site 1048689000569 D-loop; other site 1048689000570 H-loop/switch region; other site 1048689000571 inner membrane transport permease; Provisional; Region: PRK15066 1048689000572 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1048689000573 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1048689000574 active pocket/dimerization site; other site 1048689000575 active site 1048689000576 phosphorylation site [posttranslational modification] 1048689000577 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 1048689000578 putative active site [active] 1048689000579 putative metal binding site [ion binding]; other site 1048689000580 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1048689000581 tetramerization interface [polypeptide binding]; other site 1048689000582 active site 1048689000583 Uncharacterized conserved protein [Function unknown]; Region: COG5464 1048689000584 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1048689000585 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1048689000586 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1048689000587 active site 1048689000588 ATP-binding site [chemical binding]; other site 1048689000589 pantoate-binding site; other site 1048689000590 HXXH motif; other site 1048689000591 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1048689000592 oligomerization interface [polypeptide binding]; other site 1048689000593 active site 1048689000594 metal binding site [ion binding]; metal-binding site 1048689000595 Fimbrial protein; Region: Fimbrial; cl01416 1048689000596 putative fimbrial protein StaF; Provisional; Region: PRK15262 1048689000597 putative fimbrial protein StaE; Provisional; Region: PRK15263 1048689000598 Fimbrial protein; Region: Fimbrial; cl01416 1048689000599 putative fimbrial outer membrane usher protein; Provisional; Region: PRK09828 1048689000600 PapC N-terminal domain; Region: PapC_N; pfam13954 1048689000601 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1048689000602 PapC C-terminal domain; Region: PapC_C; pfam13953 1048689000603 putative chaperone protein EcpD; Provisional; Region: PRK09926 1048689000604 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1048689000605 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1048689000606 Fimbrial protein; Region: Fimbrial; cl01416 1048689000607 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1048689000608 catalytic center binding site [active] 1048689000609 ATP binding site [chemical binding]; other site 1048689000610 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 1048689000611 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1048689000612 active site 1048689000613 NTP binding site [chemical binding]; other site 1048689000614 metal binding triad [ion binding]; metal-binding site 1048689000615 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1048689000616 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 1048689000617 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 1048689000618 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 1048689000619 active site 1048689000620 nucleotide binding site [chemical binding]; other site 1048689000621 HIGH motif; other site 1048689000622 KMSKS motif; other site 1048689000623 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 1048689000624 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 1048689000625 2'-5' RNA ligase; Provisional; Region: PRK15124 1048689000626 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1048689000627 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1048689000628 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 1048689000629 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1048689000630 ATP binding site [chemical binding]; other site 1048689000631 putative Mg++ binding site [ion binding]; other site 1048689000632 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1048689000633 nucleotide binding region [chemical binding]; other site 1048689000634 ATP-binding site [chemical binding]; other site 1048689000635 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 1048689000636 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1048689000637 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 1048689000638 Transglycosylase; Region: Transgly; pfam00912 1048689000639 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1048689000640 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1048689000641 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1048689000642 N-terminal plug; other site 1048689000643 ligand-binding site [chemical binding]; other site 1048689000644 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 1048689000645 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1048689000646 Walker A/P-loop; other site 1048689000647 ATP binding site [chemical binding]; other site 1048689000648 Q-loop/lid; other site 1048689000649 ABC transporter signature motif; other site 1048689000650 Walker B; other site 1048689000651 D-loop; other site 1048689000652 H-loop/switch region; other site 1048689000653 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1048689000654 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1048689000655 siderophore binding site; other site 1048689000656 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1048689000657 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1048689000658 ABC-ATPase subunit interface; other site 1048689000659 dimer interface [polypeptide binding]; other site 1048689000660 putative PBP binding regions; other site 1048689000661 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1048689000662 ABC-ATPase subunit interface; other site 1048689000663 dimer interface [polypeptide binding]; other site 1048689000664 putative PBP binding regions; other site 1048689000665 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1048689000666 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1048689000667 inhibitor-cofactor binding pocket; inhibition site 1048689000668 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048689000669 catalytic residue [active] 1048689000670 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1048689000671 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 1048689000672 Cl- selectivity filter; other site 1048689000673 Cl- binding residues [ion binding]; other site 1048689000674 pore gating glutamate residue; other site 1048689000675 dimer interface [polypeptide binding]; other site 1048689000676 H+/Cl- coupling transport residue; other site 1048689000677 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 1048689000678 hypothetical protein; Provisional; Region: PRK10578 1048689000679 UPF0126 domain; Region: UPF0126; pfam03458 1048689000680 UPF0126 domain; Region: UPF0126; pfam03458 1048689000681 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 1048689000682 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 1048689000683 cobalamin binding residues [chemical binding]; other site 1048689000684 putative BtuC binding residues; other site 1048689000685 dimer interface [polypeptide binding]; other site 1048689000686 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1048689000687 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1048689000688 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 1048689000689 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1048689000690 Zn2+ binding site [ion binding]; other site 1048689000691 Mg2+ binding site [ion binding]; other site 1048689000692 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1048689000693 serine endoprotease; Provisional; Region: PRK10942 1048689000694 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1048689000695 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1048689000696 protein binding site [polypeptide binding]; other site 1048689000697 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1048689000698 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 1048689000699 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1048689000700 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1048689000701 hypothetical protein; Provisional; Region: PRK13677 1048689000702 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 1048689000703 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1048689000704 trimer interface [polypeptide binding]; other site 1048689000705 active site 1048689000706 substrate binding site [chemical binding]; other site 1048689000707 CoA binding site [chemical binding]; other site 1048689000708 PII uridylyl-transferase; Provisional; Region: PRK05007 1048689000709 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1048689000710 metal binding triad; other site 1048689000711 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1048689000712 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1048689000713 Zn2+ binding site [ion binding]; other site 1048689000714 Mg2+ binding site [ion binding]; other site 1048689000715 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 1048689000716 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 1048689000717 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1048689000718 active site 1048689000719 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1048689000720 rRNA interaction site [nucleotide binding]; other site 1048689000721 S8 interaction site; other site 1048689000722 putative laminin-1 binding site; other site 1048689000723 elongation factor Ts; Provisional; Region: tsf; PRK09377 1048689000724 UBA/TS-N domain; Region: UBA; pfam00627 1048689000725 Elongation factor TS; Region: EF_TS; pfam00889 1048689000726 Elongation factor TS; Region: EF_TS; pfam00889 1048689000727 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1048689000728 putative nucleotide binding site [chemical binding]; other site 1048689000729 uridine monophosphate binding site [chemical binding]; other site 1048689000730 homohexameric interface [polypeptide binding]; other site 1048689000731 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1048689000732 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1048689000733 hinge region; other site 1048689000734 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1048689000735 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1048689000736 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1048689000737 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1048689000738 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1048689000739 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1048689000740 catalytic residue [active] 1048689000741 putative FPP diphosphate binding site; other site 1048689000742 putative FPP binding hydrophobic cleft; other site 1048689000743 dimer interface [polypeptide binding]; other site 1048689000744 putative IPP diphosphate binding site; other site 1048689000745 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 1048689000746 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1048689000747 zinc metallopeptidase RseP; Provisional; Region: PRK10779 1048689000748 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1048689000749 active site 1048689000750 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1048689000751 protein binding site [polypeptide binding]; other site 1048689000752 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1048689000753 putative substrate binding region [chemical binding]; other site 1048689000754 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 1048689000755 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1048689000756 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1048689000757 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1048689000758 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1048689000759 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1048689000760 Surface antigen; Region: Bac_surface_Ag; pfam01103 1048689000761 periplasmic chaperone; Provisional; Region: PRK10780 1048689000762 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 1048689000763 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1048689000764 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1048689000765 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1048689000766 trimer interface [polypeptide binding]; other site 1048689000767 active site 1048689000768 UDP-GlcNAc binding site [chemical binding]; other site 1048689000769 lipid binding site [chemical binding]; lipid-binding site 1048689000770 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1048689000771 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1048689000772 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1048689000773 active site 1048689000774 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1048689000775 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1048689000776 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1048689000777 RNA/DNA hybrid binding site [nucleotide binding]; other site 1048689000778 active site 1048689000779 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1048689000780 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 1048689000781 putative active site [active] 1048689000782 putative PHP Thumb interface [polypeptide binding]; other site 1048689000783 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1048689000784 generic binding surface II; other site 1048689000785 generic binding surface I; other site 1048689000786 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1048689000787 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1048689000788 lysine decarboxylase LdcC; Provisional; Region: PRK15399 1048689000789 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1048689000790 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1048689000791 homodimer interface [polypeptide binding]; other site 1048689000792 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048689000793 catalytic residue [active] 1048689000794 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1048689000795 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 1048689000796 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1048689000797 putative metal binding site [ion binding]; other site 1048689000798 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 1048689000799 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1048689000800 Ligand Binding Site [chemical binding]; other site 1048689000801 TilS substrate binding domain; Region: TilS; pfam09179 1048689000802 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 1048689000803 Rho-binding antiterminator; Provisional; Region: PRK11625 1048689000804 hypothetical protein; Provisional; Region: PRK04964 1048689000805 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 1048689000806 hypothetical protein; Provisional; Region: PRK09256 1048689000807 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1048689000808 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 1048689000809 NlpE N-terminal domain; Region: NlpE; pfam04170 1048689000810 hypothetical protein; Provisional; Region: PRK11479 1048689000811 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 1048689000812 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1048689000813 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1048689000814 dimer interface [polypeptide binding]; other site 1048689000815 motif 1; other site 1048689000816 active site 1048689000817 motif 2; other site 1048689000818 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1048689000819 putative deacylase active site [active] 1048689000820 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1048689000821 active site 1048689000822 motif 3; other site 1048689000823 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1048689000824 anticodon binding site; other site 1048689000825 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 1048689000826 homodimer interaction site [polypeptide binding]; other site 1048689000827 cofactor binding site; other site 1048689000828 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 1048689000829 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 1048689000830 lipoprotein, YaeC family; Region: TIGR00363 1048689000831 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048689000832 dimer interface [polypeptide binding]; other site 1048689000833 conserved gate region; other site 1048689000834 ABC-ATPase subunit interface; other site 1048689000835 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1048689000836 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1048689000837 Walker A/P-loop; other site 1048689000838 ATP binding site [chemical binding]; other site 1048689000839 Q-loop/lid; other site 1048689000840 ABC transporter signature motif; other site 1048689000841 Walker B; other site 1048689000842 D-loop; other site 1048689000843 H-loop/switch region; other site 1048689000844 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1048689000845 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 1048689000846 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1048689000847 active site 1048689000848 motif I; other site 1048689000849 motif II; other site 1048689000850 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1048689000851 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1048689000852 active site 1048689000853 catalytic tetrad [active] 1048689000854 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1048689000855 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1048689000856 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 1048689000857 putative effector binding pocket; other site 1048689000858 dimerization interface [polypeptide binding]; other site 1048689000859 hypothetical protein; Provisional; Region: PRK05421 1048689000860 putative catalytic site [active] 1048689000861 putative metal binding site [ion binding]; other site 1048689000862 putative phosphate binding site [ion binding]; other site 1048689000863 putative catalytic site [active] 1048689000864 putative phosphate binding site [ion binding]; other site 1048689000865 putative metal binding site [ion binding]; other site 1048689000866 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1048689000867 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1048689000868 S-adenosylmethionine binding site [chemical binding]; other site 1048689000869 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 1048689000870 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1048689000871 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1048689000872 catalytic residue [active] 1048689000873 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1048689000874 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1048689000875 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 1048689000876 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1048689000877 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1048689000878 RNA/DNA hybrid binding site [nucleotide binding]; other site 1048689000879 active site 1048689000880 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 1048689000881 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 1048689000882 active site 1048689000883 catalytic site [active] 1048689000884 substrate binding site [chemical binding]; other site 1048689000885 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 1048689000886 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 1048689000887 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 1048689000888 ImpA domain protein; Region: DUF3702; pfam12486 1048689000889 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 1048689000890 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 1048689000891 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 1048689000892 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 1048689000893 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 1048689000894 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 1048689000895 type VI secretion-associated protein, VC_A0118 family; Region: VI_minor_1; TIGR03360 1048689000896 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 1048689000897 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1048689000898 Walker A motif; other site 1048689000899 ATP binding site [chemical binding]; other site 1048689000900 Walker B motif; other site 1048689000901 arginine finger; other site 1048689000902 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1048689000903 Walker A motif; other site 1048689000904 ATP binding site [chemical binding]; other site 1048689000905 Walker B motif; other site 1048689000906 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1048689000907 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 1048689000908 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 1048689000909 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 1048689000910 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3521 1048689000911 Predicted component of the type VI protein secretion system, contains a FHA domain [Intracellular trafficking, secretion, and vesicular transport; Signal transduction mechanisms]; Region: COG3456 1048689000912 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3520 1048689000913 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 1048689000914 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 1048689000915 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 1048689000916 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 1048689000917 Protein of unknown function (DUF877); Region: DUF877; pfam05943 1048689000918 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 1048689000919 Protein of unknown function (DUF877); Region: DUF877; pfam05943 1048689000920 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 1048689000921 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 1048689000922 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 1048689000923 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1048689000924 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1048689000925 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1048689000926 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 1048689000927 PAAR motif; Region: PAAR_motif; cl15808 1048689000928 RHS Repeat; Region: RHS_repeat; pfam05593 1048689000929 RHS Repeat; Region: RHS_repeat; pfam05593 1048689000930 RHS Repeat; Region: RHS_repeat; cl11982 1048689000931 RHS Repeat; Region: RHS_repeat; cl11982 1048689000932 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1048689000933 RHS Repeat; Region: RHS_repeat; pfam05593 1048689000934 RHS Repeat; Region: RHS_repeat; pfam05593 1048689000935 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1048689000936 RHS protein; Region: RHS; pfam03527 1048689000937 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1048689000938 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1048689000939 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1048689000940 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 1048689000941 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1048689000942 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1048689000943 RHS protein; Region: RHS; pfam03527 1048689000944 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1048689000945 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1048689000946 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1048689000947 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1048689000948 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1048689000949 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1048689000950 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1048689000951 Erythromycin esterase; Region: Erythro_esteras; cl17110 1048689000952 RHS protein; Region: RHS; pfam03527 1048689000953 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1048689000954 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1048689000955 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1048689000956 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1048689000957 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1048689000958 C-N hydrolase family amidase; Provisional; Region: PRK10438 1048689000959 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 1048689000960 putative active site [active] 1048689000961 catalytic triad [active] 1048689000962 dimer interface [polypeptide binding]; other site 1048689000963 multimer interface [polypeptide binding]; other site 1048689000964 C-lysozyme inhibitor; Provisional; Region: PRK09993 1048689000965 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 1048689000966 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1048689000967 active site 1048689000968 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 1048689000969 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1048689000970 dimer interface [polypeptide binding]; other site 1048689000971 active site 1048689000972 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 1048689000973 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1048689000974 putative active site [active] 1048689000975 putative dimer interface [polypeptide binding]; other site 1048689000976 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 1048689000977 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1048689000978 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041 1048689000979 RelB antitoxin; Region: RelB; cl01171 1048689000980 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1048689000981 NlpC/P60 family; Region: NLPC_P60; pfam00877 1048689000982 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 1048689000983 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 1048689000984 hypothetical protein; Validated; Region: PRK06778 1048689000985 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1048689000986 ligand binding site [chemical binding]; other site 1048689000987 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1048689000988 active site 1048689000989 DNA polymerase IV; Validated; Region: PRK02406 1048689000990 DNA binding site [nucleotide binding] 1048689000991 putative antitoxin of the YafO-YafN toxin-antitoxin system; Provisional; Region: PRK09778 1048689000992 putative toxin YafO; Provisional; Region: PRK09885 1048689000993 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1048689000994 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1048689000995 Coenzyme A binding pocket [chemical binding]; other site 1048689000996 Uncharacterized protein family UPF0027; Region: UPF0027; cl17455 1048689000997 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1048689000998 peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179 1048689000999 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 1048689001000 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 1048689001001 metal binding site [ion binding]; metal-binding site 1048689001002 dimer interface [polypeptide binding]; other site 1048689001003 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1048689001004 active site 1048689001005 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 1048689001006 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 1048689001007 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1048689001008 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1048689001009 trimer interface [polypeptide binding]; other site 1048689001010 eyelet of channel; other site 1048689001011 gamma-glutamyl kinase; Provisional; Region: PRK05429 1048689001012 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1048689001013 nucleotide binding site [chemical binding]; other site 1048689001014 homotetrameric interface [polypeptide binding]; other site 1048689001015 putative phosphate binding site [ion binding]; other site 1048689001016 putative allosteric binding site; other site 1048689001017 PUA domain; Region: PUA; pfam01472 1048689001018 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1048689001019 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1048689001020 putative catalytic cysteine [active] 1048689001021 prophage Cp1 1048689001022 integrase; Provisional; Region: int; PHA02601 1048689001023 P22-like integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial and phage integrases, including those similar to phage P22-like integrases, DLP12 and APSE-1; Region: INT_P22_C; cd01192 1048689001024 Int/Topo IB signature motif; other site 1048689001025 Helix-turn-helix domain; Region: HTH_17; pfam12728 1048689001026 Protein of unknown function (DUF550); Region: DUF550; pfam04447 1048689001027 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 1048689001028 DksA-like zinc finger domain containing protein; Region: PHA00080 1048689001029 Protein of unknown function (DUF1382); Region: DUF1382; pfam07131 1048689001030 Protein of unknown function (DUF1317); Region: DUF1317; pfam07026 1048689001031 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 1048689001032 phage recombination protein Bet; Region: bet_lambda; TIGR01913 1048689001033 Host-nuclease inhibitor protein Gam; Region: Gam; pfam06064 1048689001034 Bacteriophage lambda Kil protein; Region: Lambda_Kil; pfam06301 1048689001035 Antirestriction protein Ral; Region: Ral; pfam11058 1048689001036 Superinfection exclusion protein B; Region: SieB; pfam14163 1048689001037 36-mer N-terminal peptide of the N protein (N36); Region: N36; pfam11438 1048689001038 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1048689001039 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1048689001040 non-specific DNA binding site [nucleotide binding]; other site 1048689001041 salt bridge; other site 1048689001042 sequence-specific DNA binding site [nucleotide binding]; other site 1048689001043 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1048689001044 Catalytic site [active] 1048689001045 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1048689001046 sequence-specific DNA binding site [nucleotide binding]; other site 1048689001047 salt bridge; other site 1048689001048 Bacteriophage CII protein; Region: Phage_CII; pfam05269 1048689001049 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 1048689001050 Replication protein P; Region: Phage_lambda_P; pfam06992 1048689001051 NinB protein; Region: NinB; pfam05772 1048689001052 phage N-6-adenine-methyltransferase; Region: phage_N6A_met; TIGR01712 1048689001053 NINE Protein; Region: NinE; pfam05322 1048689001054 NinF protein; Region: NinF; pfam05810 1048689001055 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 1048689001056 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 1048689001057 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1048689001058 active site 1048689001059 metal binding site [ion binding]; metal-binding site 1048689001060 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 1048689001061 Protein of unknown function (DUF3927); Region: DUF3927; pfam13064 1048689001062 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 1048689001063 Domain of unknown function (DUF303); Region: DUF303; pfam03629 1048689001064 Lysis protein S; Region: Lysis_S; pfam04971 1048689001065 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1048689001066 catalytic residues [active] 1048689001067 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 1048689001068 PerC transcriptional activator; Region: PerC; pfam06069 1048689001069 Phage DNA packaging protein, Nu1 subunit of terminase [DNA replication, recombination, and repair]; Region: COG4220 1048689001070 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 1048689001071 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 1048689001072 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 1048689001073 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 1048689001074 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1048689001075 tandem repeat interface [polypeptide binding]; other site 1048689001076 oligomer interface [polypeptide binding]; other site 1048689001077 active site residues [active] 1048689001078 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 1048689001079 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 1048689001080 DNA packaging protein FI; Region: Packaging_FI; pfam14000 1048689001081 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 1048689001082 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 1048689001083 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 1048689001084 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 1048689001085 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 1048689001086 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894 1048689001087 Minor tail protein T; Region: Phage_tail_T; pfam06223 1048689001088 Phage-related minor tail protein [Function unknown]; Region: COG5281 1048689001089 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 1048689001090 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 1048689001091 Phage-related protein [Function unknown]; Region: COG4718 1048689001092 Phage-related protein [Function unknown]; Region: gp18; COG4672 1048689001093 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 1048689001094 MPN+ (JAMM) motif; other site 1048689001095 Zinc-binding site [ion binding]; other site 1048689001096 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1048689001097 NlpC/P60 family; Region: NLPC_P60; cl17555 1048689001098 Phage-related protein, tail component [Function unknown]; Region: COG4723 1048689001099 Phage-related protein, tail component [Function unknown]; Region: COG4733 1048689001100 Putative phage tail protein; Region: Phage-tail_3; pfam13550 1048689001101 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 1048689001102 Fibronectin type III protein; Region: DUF3672; pfam12421 1048689001103 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 1048689001104 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 1048689001105 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 1048689001106 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 1048689001107 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 1048689001108 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 1048689001109 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 1048689001110 IpaB/EvcA family; Region: IpaB_EvcA; pfam03278 1048689001111 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1048689001112 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1048689001113 non-LEE encoded effector protein NleB; Provisional; Region: PRK15382 1048689001114 type III secretion system protein; Provisional; Region: PRK15384; cl14665 1048689001115 potential frameshift: common BLAST hit: gi|260844436|ref|YP_003222214.1| T3SS secreted effector EspK-like protein 1048689001116 prophage Cp2 1048689001117 integrase; Provisional; Region: PRK09692 1048689001118 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1048689001119 active site 1048689001120 Int/Topo IB signature motif; other site 1048689001121 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 1048689001122 Phage polarity suppression protein (Psu); Region: Psu; pfam07455 1048689001123 Phage polarity suppression protein (Psu); Region: Psu; pfam07455 1048689001124 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 1048689001125 Ash protein family; Region: Phage_ASH; pfam10554 1048689001126 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 1048689001127 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 1048689001128 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 1048689001129 active site 1048689001130 metal binding site [ion binding]; metal-binding site 1048689001131 interdomain interaction site; other site 1048689001132 D5 N terminal like; Region: D5_N; smart00885 1048689001133 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 1048689001134 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 1048689001135 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1048689001136 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1048689001137 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1048689001138 putative effector binding pocket; other site 1048689001139 putative dimerization interface [polypeptide binding]; other site 1048689001140 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1048689001141 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1048689001142 NAD(P) binding site [chemical binding]; other site 1048689001143 active site 1048689001144 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1048689001145 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1048689001146 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1048689001147 putative effector binding pocket; other site 1048689001148 putative dimerization interface [polypeptide binding]; other site 1048689001149 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1048689001150 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1048689001151 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689001152 putative substrate translocation pore; other site 1048689001153 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1048689001154 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1048689001155 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1048689001156 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1048689001157 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 1048689001158 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1048689001159 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1048689001160 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 1048689001161 aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433 1048689001162 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1048689001163 catalytic loop [active] 1048689001164 iron binding site [ion binding]; other site 1048689001165 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1048689001166 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 1048689001167 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 1048689001168 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1048689001169 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 1048689001170 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1048689001171 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1048689001172 DNA binding residues [nucleotide binding] 1048689001173 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 1048689001174 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1048689001175 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1048689001176 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 1048689001177 putative active site [active] 1048689001178 putative FMN binding site [chemical binding]; other site 1048689001179 putative substrate binding site [chemical binding]; other site 1048689001180 putative catalytic residue [active] 1048689001181 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1048689001182 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1048689001183 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1048689001184 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1048689001185 putative effector binding pocket; other site 1048689001186 putative dimerization interface [polypeptide binding]; other site 1048689001187 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1048689001188 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1048689001189 active site 1048689001190 catalytic tetrad [active] 1048689001191 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 1048689001192 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1048689001193 Filamin/ABP280 repeat; Region: Filamin; pfam00630 1048689001194 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1048689001195 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1048689001196 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1048689001197 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 1048689001198 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1048689001199 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1048689001200 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1048689001201 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1048689001202 active site 1048689001203 catalytic tetrad [active] 1048689001204 Predicted membrane protein [Function unknown]; Region: COG3059 1048689001205 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1048689001206 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010 1048689001207 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1048689001208 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1048689001209 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1048689001210 Cupin; Region: Cupin_6; pfam12852 1048689001211 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1048689001212 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1048689001213 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1048689001214 Cysteine-rich domain; Region: CCG; pfam02754 1048689001215 Cysteine-rich domain; Region: CCG; pfam02754 1048689001216 iron-sulfur cluster-binding protein; Region: TIGR00273 1048689001217 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1048689001218 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1048689001219 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 1048689001220 Uncharacterized conserved protein [Function unknown]; Region: COG1556 1048689001221 potential frameshift: common BLAST hit: gi|291281210|ref|YP_003498028.1| autotransporter 1048689001222 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1048689001223 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1048689001224 DNA binding residues [nucleotide binding] 1048689001225 dimerization interface [polypeptide binding]; other site 1048689001226 potential frameshift: common BLAST hit: gi|209917522|ref|YP_002291606.1| putative phage integrase 1048689001227 choline dehydrogenase; Validated; Region: PRK02106 1048689001228 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1048689001229 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 1048689001230 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 1048689001231 tetrameric interface [polypeptide binding]; other site 1048689001232 NAD binding site [chemical binding]; other site 1048689001233 catalytic residues [active] 1048689001234 transcriptional regulator BetI; Validated; Region: PRK00767 1048689001235 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1048689001236 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1048689001237 choline transport protein BetT; Provisional; Region: PRK09928 1048689001238 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 1048689001239 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 1048689001240 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1048689001241 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1048689001242 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1048689001243 DNA binding residues [nucleotide binding] 1048689001244 dimerization interface [polypeptide binding]; other site 1048689001245 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1048689001246 potential frameshift: common BLAST hit: gi|218557242|ref|YP_002390155.1| DNA-binding transcriptional regulator 1048689001247 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 1048689001248 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1048689001249 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1048689001250 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1048689001251 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 1048689001252 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 1048689001253 CoA binding domain; Region: CoA_binding; pfam02629 1048689001254 CoA-ligase; Region: Ligase_CoA; pfam00549 1048689001255 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 1048689001256 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 1048689001257 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1048689001258 putative substrate binding site [chemical binding]; other site 1048689001259 nucleotide binding site [chemical binding]; other site 1048689001260 nucleotide binding site [chemical binding]; other site 1048689001261 homodimer interface [polypeptide binding]; other site 1048689001262 putative deaminase; Validated; Region: PRK06846 1048689001263 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1048689001264 active site 1048689001265 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 1048689001266 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 1048689001267 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1048689001268 ligand binding site [chemical binding]; other site 1048689001269 potential frameshift: common BLAST hit: gi|218698769|ref|YP_002406398.1| putative ATP-binding protein of ABC sugar transport system 1048689001270 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1048689001271 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1048689001272 TM-ABC transporter signature motif; other site 1048689001273 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1048689001274 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1048689001275 TM-ABC transporter signature motif; other site 1048689001276 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1048689001277 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1048689001278 putative NAD(P) binding site [chemical binding]; other site 1048689001279 putative substrate binding site [chemical binding]; other site 1048689001280 catalytic Zn binding site [ion binding]; other site 1048689001281 structural Zn binding site [ion binding]; other site 1048689001282 dimer interface [polypeptide binding]; other site 1048689001283 The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949 1048689001284 hypothetical protein; Provisional; Region: PRK09929 1048689001285 propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424 1048689001286 Propionate catabolism activator; Region: PrpR_N; pfam06506 1048689001287 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1048689001288 Walker A motif; other site 1048689001289 ATP binding site [chemical binding]; other site 1048689001290 Walker B motif; other site 1048689001291 arginine finger; other site 1048689001292 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1048689001293 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1048689001294 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1048689001295 tetramer interface [polypeptide binding]; other site 1048689001296 active site 1048689001297 Mg2+/Mn2+ binding site [ion binding]; other site 1048689001298 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1048689001299 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 1048689001300 dimer interface [polypeptide binding]; other site 1048689001301 active site 1048689001302 citrylCoA binding site [chemical binding]; other site 1048689001303 oxalacetate/citrate binding site [chemical binding]; other site 1048689001304 coenzyme A binding site [chemical binding]; other site 1048689001305 catalytic triad [active] 1048689001306 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 1048689001307 2-methylcitrate dehydratase; Region: prpD; TIGR02330 1048689001308 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 1048689001309 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 1048689001310 acyl-activating enzyme (AAE) consensus motif; other site 1048689001311 putative AMP binding site [chemical binding]; other site 1048689001312 putative active site [active] 1048689001313 putative CoA binding site [chemical binding]; other site 1048689001314 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 1048689001315 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1048689001316 Na binding site [ion binding]; other site 1048689001317 putative substrate binding site [chemical binding]; other site 1048689001318 cytosine deaminase; Provisional; Region: PRK09230 1048689001319 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1048689001320 active site 1048689001321 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 1048689001322 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1048689001323 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425 1048689001324 dimerization interface [polypeptide binding]; other site 1048689001325 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 1048689001326 active site clefts [active] 1048689001327 zinc binding site [ion binding]; other site 1048689001328 dimer interface [polypeptide binding]; other site 1048689001329 Cyanate lyase [Inorganic ion transport and metabolism]; Region: CynS; COG1513 1048689001330 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 1048689001331 oligomer interface [polypeptide binding]; other site 1048689001332 active site 1048689001333 putative cyanate transporter; Provisional; Region: cynX; PRK09705 1048689001334 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689001335 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 1048689001336 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1048689001337 active site 1048689001338 substrate binding site [chemical binding]; other site 1048689001339 trimer interface [polypeptide binding]; other site 1048689001340 CoA binding site [chemical binding]; other site 1048689001341 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 1048689001342 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689001343 putative substrate translocation pore; other site 1048689001344 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 1048689001345 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1048689001346 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1048689001347 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1048689001348 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 1048689001349 lac repressor; Reviewed; Region: lacI; PRK09526 1048689001350 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1048689001351 DNA binding site [nucleotide binding] 1048689001352 domain linker motif; other site 1048689001353 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 1048689001354 ligand binding site [chemical binding]; other site 1048689001355 dimerization interface (open form) [polypeptide binding]; other site 1048689001356 dimerization interface (closed form) [polypeptide binding]; other site 1048689001357 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1048689001358 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1048689001359 conserved cys residue [active] 1048689001360 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1048689001361 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1048689001362 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1048689001363 DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834 1048689001364 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1048689001365 Bacterial transcriptional regulator; Region: IclR; pfam01614 1048689001366 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 1048689001367 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1048689001368 Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB), which catalyzes the oxidization and subsequent ring-opening of 2,3-dihydroxyphenylpropionate; Region: MhpB_like; cd07365 1048689001369 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1048689001370 putative active site [active] 1048689001371 Fe(II) binding site [ion binding]; other site 1048689001372 putative dimer interface [polypeptide binding]; other site 1048689001373 putative tetramer interface [polypeptide binding]; other site 1048689001374 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 1048689001375 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1048689001376 nucleophilic elbow; other site 1048689001377 catalytic triad; other site 1048689001378 2-keto-4-pentenoate hydratase; Provisional; Region: mhpD; PRK11342 1048689001379 acetaldehyde dehydrogenase; Validated; Region: PRK08300 1048689001380 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1048689001381 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 1048689001382 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1048689001383 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 1048689001384 active site 1048689001385 catalytic residues [active] 1048689001386 metal binding site [ion binding]; metal-binding site 1048689001387 DmpG-like communication domain; Region: DmpG_comm; pfam07836 1048689001388 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 1048689001389 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689001390 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689001391 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 1048689001392 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 1048689001393 S-formylglutathione hydrolase; Region: PLN02442 1048689001394 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 1048689001395 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 1048689001396 substrate binding site [chemical binding]; other site 1048689001397 catalytic Zn binding site [ion binding]; other site 1048689001398 NAD binding site [chemical binding]; other site 1048689001399 structural Zn binding site [ion binding]; other site 1048689001400 dimer interface [polypeptide binding]; other site 1048689001401 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 1048689001402 putative metal binding site [ion binding]; other site 1048689001403 putative homodimer interface [polypeptide binding]; other site 1048689001404 putative homotetramer interface [polypeptide binding]; other site 1048689001405 putative homodimer-homodimer interface [polypeptide binding]; other site 1048689001406 putative allosteric switch controlling residues; other site 1048689001407 ferric transporter ATP-binding subunit; Provisional; Region: fbpC; PRK11432 1048689001408 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1048689001409 Walker A/P-loop; other site 1048689001410 ATP binding site [chemical binding]; other site 1048689001411 Q-loop/lid; other site 1048689001412 ABC transporter signature motif; other site 1048689001413 Walker B; other site 1048689001414 D-loop; other site 1048689001415 H-loop/switch region; other site 1048689001416 TOBE domain; Region: TOBE_2; pfam08402 1048689001417 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1048689001418 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048689001419 dimer interface [polypeptide binding]; other site 1048689001420 conserved gate region; other site 1048689001421 putative PBP binding loops; other site 1048689001422 ABC-ATPase subunit interface; other site 1048689001423 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048689001424 dimer interface [polypeptide binding]; other site 1048689001425 conserved gate region; other site 1048689001426 putative PBP binding loops; other site 1048689001427 ABC-ATPase subunit interface; other site 1048689001428 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1048689001429 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1048689001430 regulatory protein UhpC; Provisional; Region: PRK11663 1048689001431 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689001432 putative substrate translocation pore; other site 1048689001433 Signal transduction histidine kinase, glucose-6-phosphate specific [Signal transduction mechanisms]; Region: UhpB; COG3851 1048689001434 MASE1; Region: MASE1; pfam05231 1048689001435 Histidine kinase; Region: HisKA_3; pfam07730 1048689001436 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1048689001437 ATP binding site [chemical binding]; other site 1048689001438 Mg2+ binding site [ion binding]; other site 1048689001439 G-X-G motif; other site 1048689001440 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1048689001441 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1048689001442 active site 1048689001443 phosphorylation site [posttranslational modification] 1048689001444 intermolecular recognition site; other site 1048689001445 dimerization interface [polypeptide binding]; other site 1048689001446 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1048689001447 DNA binding residues [nucleotide binding] 1048689001448 dimerization interface [polypeptide binding]; other site 1048689001449 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 1048689001450 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1048689001451 substrate binding pocket [chemical binding]; other site 1048689001452 membrane-bound complex binding site; other site 1048689001453 hinge residues; other site 1048689001454 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 1048689001455 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1048689001456 Walker A/P-loop; other site 1048689001457 ATP binding site [chemical binding]; other site 1048689001458 Q-loop/lid; other site 1048689001459 ABC transporter signature motif; other site 1048689001460 Walker B; other site 1048689001461 D-loop; other site 1048689001462 H-loop/switch region; other site 1048689001463 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1048689001464 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048689001465 dimer interface [polypeptide binding]; other site 1048689001466 conserved gate region; other site 1048689001467 putative PBP binding loops; other site 1048689001468 ABC-ATPase subunit interface; other site 1048689001469 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1048689001470 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 1048689001471 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1048689001472 dimer interface [polypeptide binding]; other site 1048689001473 active site 1048689001474 Schiff base residues; other site 1048689001475 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 1048689001476 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1048689001477 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1048689001478 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 1048689001479 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 1048689001480 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1048689001481 microcin B17 transporter; Reviewed; Region: PRK11098 1048689001482 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 1048689001483 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 1048689001484 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 1048689001485 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1048689001486 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1048689001487 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1048689001488 anti-RssB factor; Provisional; Region: PRK10244 1048689001489 alkaline phosphatase; Provisional; Region: PRK10518 1048689001490 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1048689001491 dimer interface [polypeptide binding]; other site 1048689001492 active site 1048689001493 hypothetical protein; Provisional; Region: PRK11505 1048689001494 psiF repeat; Region: PsiF_repeat; pfam07769 1048689001495 psiF repeat; Region: PsiF_repeat; pfam07769 1048689001496 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 1048689001497 MASE2 domain; Region: MASE2; pfam05230 1048689001498 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1048689001499 metal binding site [ion binding]; metal-binding site 1048689001500 active site 1048689001501 I-site; other site 1048689001502 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1048689001503 pyrroline-5-carboxylate reductase; Region: PLN02688 1048689001504 hypothetical protein; Validated; Region: PRK00124 1048689001505 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 1048689001506 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1048689001507 ADP binding site [chemical binding]; other site 1048689001508 magnesium binding site [ion binding]; other site 1048689001509 putative shikimate binding site; other site 1048689001510 hypothetical protein; Provisional; Region: PRK10380 1048689001511 hypothetical protein; Provisional; Region: PRK10481 1048689001512 hypothetical protein; Provisional; Region: PRK10579 1048689001513 Protein of unknown function (DUF2773); Region: DUF2773; pfam10971 1048689001514 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 1048689001515 DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974 1048689001516 fructokinase; Reviewed; Region: PRK09557 1048689001517 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1048689001518 nucleotide binding site [chemical binding]; other site 1048689001519 MFS transport protein AraJ; Provisional; Region: PRK10091 1048689001520 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689001521 putative substrate translocation pore; other site 1048689001522 exonuclease subunit SbcC; Provisional; Region: PRK10246 1048689001523 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1048689001524 Walker A/P-loop; other site 1048689001525 ATP binding site [chemical binding]; other site 1048689001526 Q-loop/lid; other site 1048689001527 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1048689001528 ABC transporter signature motif; other site 1048689001529 Walker B; other site 1048689001530 D-loop; other site 1048689001531 H-loop/switch region; other site 1048689001532 exonuclease subunit SbcD; Provisional; Region: PRK10966 1048689001533 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1048689001534 active site 1048689001535 metal binding site [ion binding]; metal-binding site 1048689001536 DNA binding site [nucleotide binding] 1048689001537 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1048689001538 transcriptional regulator PhoB; Provisional; Region: PRK10161 1048689001539 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1048689001540 active site 1048689001541 phosphorylation site [posttranslational modification] 1048689001542 intermolecular recognition site; other site 1048689001543 dimerization interface [polypeptide binding]; other site 1048689001544 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1048689001545 DNA binding site [nucleotide binding] 1048689001546 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 1048689001547 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 1048689001548 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1048689001549 putative active site [active] 1048689001550 heme pocket [chemical binding]; other site 1048689001551 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1048689001552 dimer interface [polypeptide binding]; other site 1048689001553 phosphorylation site [posttranslational modification] 1048689001554 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1048689001555 ATP binding site [chemical binding]; other site 1048689001556 Mg2+ binding site [ion binding]; other site 1048689001557 G-X-G motif; other site 1048689001558 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 1048689001559 putative proline-specific permease; Provisional; Region: proY; PRK10580 1048689001560 Spore germination protein; Region: Spore_permease; cl17796 1048689001561 maltodextrin glucosidase; Provisional; Region: PRK10785 1048689001562 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 1048689001563 homodimer interface [polypeptide binding]; other site 1048689001564 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1048689001565 active site 1048689001566 homodimer interface [polypeptide binding]; other site 1048689001567 catalytic site [active] 1048689001568 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 1048689001569 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1048689001570 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1048689001571 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1048689001572 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 1048689001573 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1048689001574 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 1048689001575 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1048689001576 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1048689001577 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1048689001578 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1048689001579 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1048689001580 Protein export membrane protein; Region: SecD_SecF; pfam02355 1048689001581 Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693 1048689001582 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 1048689001583 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1048689001584 active site 1048689001585 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 1048689001586 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 1048689001587 hypothetical protein; Provisional; Region: PRK11530 1048689001588 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1048689001589 ATP cone domain; Region: ATP-cone; pfam03477 1048689001590 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 1048689001591 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1048689001592 catalytic motif [active] 1048689001593 Zn binding site [ion binding]; other site 1048689001594 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 1048689001595 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1048689001596 homopentamer interface [polypeptide binding]; other site 1048689001597 active site 1048689001598 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1048689001599 putative RNA binding site [nucleotide binding]; other site 1048689001600 thiamine monophosphate kinase; Provisional; Region: PRK05731 1048689001601 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1048689001602 ATP binding site [chemical binding]; other site 1048689001603 dimerization interface [polypeptide binding]; other site 1048689001604 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1048689001605 tetramer interfaces [polypeptide binding]; other site 1048689001606 binuclear metal-binding site [ion binding]; other site 1048689001607 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1048689001608 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1048689001609 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1048689001610 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1048689001611 active site 1048689001612 catalytic tetrad [active] 1048689001613 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 1048689001614 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1048689001615 TPP-binding site; other site 1048689001616 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1048689001617 PYR/PP interface [polypeptide binding]; other site 1048689001618 dimer interface [polypeptide binding]; other site 1048689001619 TPP binding site [chemical binding]; other site 1048689001620 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1048689001621 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1048689001622 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1048689001623 substrate binding pocket [chemical binding]; other site 1048689001624 chain length determination region; other site 1048689001625 substrate-Mg2+ binding site; other site 1048689001626 catalytic residues [active] 1048689001627 aspartate-rich region 1; other site 1048689001628 active site lid residues [active] 1048689001629 aspartate-rich region 2; other site 1048689001630 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1048689001631 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 1048689001632 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1048689001633 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1048689001634 Ligand Binding Site [chemical binding]; other site 1048689001635 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1048689001636 active site residue [active] 1048689001637 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 1048689001638 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 1048689001639 conserved cys residue [active] 1048689001640 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1048689001641 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1048689001642 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1048689001643 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1048689001644 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1048689001645 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689001646 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1048689001647 putative substrate translocation pore; other site 1048689001648 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 1048689001649 UbiA prenyltransferase family; Region: UbiA; pfam01040 1048689001650 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 1048689001651 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1048689001652 Subunit I/III interface [polypeptide binding]; other site 1048689001653 Subunit III/IV interface [polypeptide binding]; other site 1048689001654 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1048689001655 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1048689001656 D-pathway; other site 1048689001657 Putative ubiquinol binding site [chemical binding]; other site 1048689001658 Low-spin heme (heme b) binding site [chemical binding]; other site 1048689001659 Putative water exit pathway; other site 1048689001660 Binuclear center (heme o3/CuB) [ion binding]; other site 1048689001661 K-pathway; other site 1048689001662 Putative proton exit pathway; other site 1048689001663 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 1048689001664 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1048689001665 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1048689001666 muropeptide transporter; Reviewed; Region: ampG; PRK11902 1048689001667 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689001668 putative substrate translocation pore; other site 1048689001669 hypothetical protein; Provisional; Region: PRK11627 1048689001670 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1048689001671 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 1048689001672 transcriptional regulator BolA; Provisional; Region: PRK11628 1048689001673 trigger factor; Provisional; Region: tig; PRK01490 1048689001674 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1048689001675 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1048689001676 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1048689001677 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1048689001678 oligomer interface [polypeptide binding]; other site 1048689001679 active site residues [active] 1048689001680 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1048689001681 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1048689001682 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1048689001683 Walker A motif; other site 1048689001684 ATP binding site [chemical binding]; other site 1048689001685 Walker B motif; other site 1048689001686 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1048689001687 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 1048689001688 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1048689001689 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1048689001690 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1048689001691 Walker A motif; other site 1048689001692 ATP binding site [chemical binding]; other site 1048689001693 Walker B motif; other site 1048689001694 arginine finger; other site 1048689001695 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1048689001696 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1048689001697 IHF dimer interface [polypeptide binding]; other site 1048689001698 IHF - DNA interface [nucleotide binding]; other site 1048689001699 periplasmic folding chaperone; Provisional; Region: PRK10788 1048689001700 SurA N-terminal domain; Region: SurA_N_3; cl07813 1048689001701 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1048689001702 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 1048689001703 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1048689001704 active site 1048689001705 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1048689001706 Ligand Binding Site [chemical binding]; other site 1048689001707 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 1048689001708 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1048689001709 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1048689001710 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 1048689001711 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1048689001712 active site 1048689001713 motif I; other site 1048689001714 motif II; other site 1048689001715 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1048689001716 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1048689001717 putative DNA binding site [nucleotide binding]; other site 1048689001718 putative Zn2+ binding site [ion binding]; other site 1048689001719 AsnC family; Region: AsnC_trans_reg; pfam01037 1048689001720 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1048689001721 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 1048689001722 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1048689001723 Walker A/P-loop; other site 1048689001724 ATP binding site [chemical binding]; other site 1048689001725 Q-loop/lid; other site 1048689001726 ABC transporter signature motif; other site 1048689001727 Walker B; other site 1048689001728 D-loop; other site 1048689001729 H-loop/switch region; other site 1048689001730 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 1048689001731 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1048689001732 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1048689001733 Walker A/P-loop; other site 1048689001734 ATP binding site [chemical binding]; other site 1048689001735 Q-loop/lid; other site 1048689001736 ABC transporter signature motif; other site 1048689001737 Walker B; other site 1048689001738 D-loop; other site 1048689001739 H-loop/switch region; other site 1048689001740 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 1048689001741 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1048689001742 ammonium transporter; Provisional; Region: PRK10666 1048689001743 acyl-CoA thioesterase II; Provisional; Region: PRK10526 1048689001744 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1048689001745 active site 1048689001746 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1048689001747 catalytic triad [active] 1048689001748 dimer interface [polypeptide binding]; other site 1048689001749 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 1048689001750 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1048689001751 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1048689001752 DNA binding site [nucleotide binding] 1048689001753 active site 1048689001754 Uncharacterized conserved protein [Function unknown]; Region: COG5507 1048689001755 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 1048689001756 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1048689001757 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1048689001758 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 1048689001759 maltose O-acetyltransferase; Provisional; Region: PRK10092 1048689001760 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1048689001761 active site 1048689001762 substrate binding site [chemical binding]; other site 1048689001763 trimer interface [polypeptide binding]; other site 1048689001764 CoA binding site [chemical binding]; other site 1048689001765 gene expression modulator; Provisional; Region: PRK10945 1048689001766 Biofilm formation regulator YbaJ; Region: YbaJ; pfam10757 1048689001767 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 1048689001768 Protein export membrane protein; Region: SecD_SecF; cl14618 1048689001769 Protein export membrane protein; Region: SecD_SecF; cl14618 1048689001770 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 1048689001771 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1048689001772 HlyD family secretion protein; Region: HlyD_3; pfam13437 1048689001773 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 1048689001774 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1048689001775 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 1048689001776 hypothetical protein; Provisional; Region: PRK11281 1048689001777 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 1048689001778 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 1048689001779 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1048689001780 hypothetical protein; Provisional; Region: PRK11038 1048689001781 primosomal replication protein N''; Provisional; Region: PRK10093 1048689001782 hypothetical protein; Provisional; Region: PRK10527 1048689001783 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1048689001784 active site 1048689001785 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 1048689001786 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1048689001787 Walker A motif; other site 1048689001788 ATP binding site [chemical binding]; other site 1048689001789 Walker B motif; other site 1048689001790 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1048689001791 arginine finger; other site 1048689001792 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1048689001793 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 1048689001794 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 1048689001795 hypothetical protein; Validated; Region: PRK00153 1048689001796 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecR; COG0353 1048689001797 RecR protein; Region: RecR; pfam02132 1048689001798 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1048689001799 putative active site [active] 1048689001800 putative metal-binding site [ion binding]; other site 1048689001801 tetramer interface [polypeptide binding]; other site 1048689001802 heat shock protein 90; Provisional; Region: PRK05218 1048689001803 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1048689001804 ATP binding site [chemical binding]; other site 1048689001805 Mg2+ binding site [ion binding]; other site 1048689001806 G-X-G motif; other site 1048689001807 adenylate kinase; Reviewed; Region: adk; PRK00279 1048689001808 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1048689001809 AMP-binding site [chemical binding]; other site 1048689001810 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1048689001811 ferrochelatase; Region: hemH; TIGR00109 1048689001812 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1048689001813 C-terminal domain interface [polypeptide binding]; other site 1048689001814 active site 1048689001815 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1048689001816 active site 1048689001817 N-terminal domain interface [polypeptide binding]; other site 1048689001818 acetyl esterase; Provisional; Region: PRK10162 1048689001819 inosine/guanosine kinase; Provisional; Region: PRK15074 1048689001820 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1048689001821 putative cation:proton antiport protein; Provisional; Region: PRK10669 1048689001822 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 1048689001823 TrkA-N domain; Region: TrkA_N; pfam02254 1048689001824 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689001825 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1048689001826 putative substrate translocation pore; other site 1048689001827 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 1048689001828 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 1048689001829 active site 1048689001830 metal binding site [ion binding]; metal-binding site 1048689001831 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1048689001832 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1048689001833 putative deacylase active site [active] 1048689001834 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 1048689001835 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 1048689001836 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1048689001837 non-specific DNA binding site [nucleotide binding]; other site 1048689001838 salt bridge; other site 1048689001839 sequence-specific DNA binding site [nucleotide binding]; other site 1048689001840 copper exporting ATPase; Provisional; Region: copA; PRK10671 1048689001841 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1048689001842 metal-binding site [ion binding] 1048689001843 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1048689001844 metal-binding site [ion binding] 1048689001845 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1048689001846 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1048689001847 motif II; other site 1048689001848 glutaminase; Reviewed; Region: PRK12356 1048689001849 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1048689001850 amino acid transporter; Region: 2A0306; TIGR00909 1048689001851 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1048689001852 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1048689001853 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1048689001854 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1048689001855 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1048689001856 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1048689001857 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1048689001858 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1048689001859 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1048689001860 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1048689001861 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1048689001862 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1048689001863 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1048689001864 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1048689001865 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1048689001866 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1048689001867 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1048689001868 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1048689001869 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1048689001870 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1048689001871 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1048689001872 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1048689001873 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1048689001874 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1048689001875 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1048689001876 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1048689001877 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1048689001878 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1048689001879 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1048689001880 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1048689001881 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1048689001882 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1048689001883 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1048689001884 Family description; Region: VCBS; pfam13517 1048689001885 Family description; Region: VCBS; pfam13517 1048689001886 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 1048689001887 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 1048689001888 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1048689001889 putative active site [active] 1048689001890 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1048689001891 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 1048689001892 Walker A/P-loop; other site 1048689001893 ATP binding site [chemical binding]; other site 1048689001894 Q-loop/lid; other site 1048689001895 ABC transporter signature motif; other site 1048689001896 Walker B; other site 1048689001897 D-loop; other site 1048689001898 H-loop/switch region; other site 1048689001899 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1048689001900 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 1048689001901 HlyD family secretion protein; Region: HlyD_3; pfam13437 1048689001902 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 1048689001903 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 1048689001904 DNA binding residues [nucleotide binding] 1048689001905 dimer interface [polypeptide binding]; other site 1048689001906 copper binding site [ion binding]; other site 1048689001907 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 1048689001908 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 1048689001909 YadA-like C-terminal region; Region: YadA; pfam03895 1048689001910 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1048689001911 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1048689001912 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1048689001913 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 1048689001914 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1048689001915 Walker A/P-loop; other site 1048689001916 ATP binding site [chemical binding]; other site 1048689001917 Q-loop/lid; other site 1048689001918 ABC transporter signature motif; other site 1048689001919 Walker B; other site 1048689001920 D-loop; other site 1048689001921 H-loop/switch region; other site 1048689001922 Uncharacterized protein family (UPF0014); Region: UPF0014; pfam03649 1048689001923 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1048689001924 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1048689001925 oxidoreductase; Provisional; Region: PRK08017 1048689001926 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1048689001927 NADP binding site [chemical binding]; other site 1048689001928 active site 1048689001929 steroid binding site; other site 1048689001930 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 1048689001931 active site 1048689001932 catalytic triad [active] 1048689001933 oxyanion hole [active] 1048689001934 switch loop; other site 1048689001935 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 1048689001936 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1048689001937 Walker A/P-loop; other site 1048689001938 ATP binding site [chemical binding]; other site 1048689001939 Q-loop/lid; other site 1048689001940 ABC transporter signature motif; other site 1048689001941 Walker B; other site 1048689001942 D-loop; other site 1048689001943 H-loop/switch region; other site 1048689001944 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 1048689001945 FtsX-like permease family; Region: FtsX; pfam02687 1048689001946 FtsX-like permease family; Region: FtsX; pfam02687 1048689001947 potential frameshift: common BLAST hit: gi|209400573|ref|YP_002269157.1| RHS Repeat family protein 1048689001948 potential frameshift: common BLAST hit: gi|209400573|ref|YP_002269157.1| RHS Repeat family protein 1048689001949 hypothetical protein; Provisional; Region: PRK14710 1048689001950 Winged helix-turn helix; Region: HTH_29; pfam13551 1048689001951 Helix-turn-helix domain; Region: HTH_28; pfam13518 1048689001952 Predicted ATPase [General function prediction only]; Region: COG2603 1048689001953 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 1048689001954 active site residue [active] 1048689001955 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 1048689001956 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1048689001957 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1048689001958 dimerization interface [polypeptide binding]; other site 1048689001959 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 1048689001960 ureidoglycolate hydrolase; Provisional; Region: PRK03606 1048689001961 DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163 1048689001962 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1048689001963 Bacterial transcriptional regulator; Region: IclR; pfam01614 1048689001964 glyoxylate carboligase; Provisional; Region: PRK11269 1048689001965 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1048689001966 PYR/PP interface [polypeptide binding]; other site 1048689001967 dimer interface [polypeptide binding]; other site 1048689001968 TPP binding site [chemical binding]; other site 1048689001969 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1048689001970 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 1048689001971 TPP-binding site [chemical binding]; other site 1048689001972 hydroxypyruvate isomerase; Provisional; Region: PRK09997 1048689001973 tartronate semialdehyde reductase; Provisional; Region: PRK15059 1048689001974 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1048689001975 nucleobase-cation-symport-1 (NCS1) transporters; solute-binding domain; Region: SLC-NCS1sbd; cd10323 1048689001976 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1048689001977 Na binding site [ion binding]; other site 1048689001978 substrate binding site [chemical binding]; other site 1048689001979 allantoinase; Provisional; Region: PRK08044 1048689001980 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 1048689001981 active site 1048689001982 putative uracil/xanthine transporter; Provisional; Region: PRK11412 1048689001983 glycerate kinase II; Provisional; Region: PRK09932 1048689001984 Uncharacterized protein, possibly involved in glyoxylate utilization [General function prediction only]; Region: GlxB; COG3257 1048689001985 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 1048689001986 Cupin domain; Region: Cupin_2; cl17218 1048689001987 allantoate amidohydrolase; Region: AllC; TIGR03176 1048689001988 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1048689001989 active site 1048689001990 metal binding site [ion binding]; metal-binding site 1048689001991 dimer interface [polypeptide binding]; other site 1048689001992 ureidoglycolate dehydrogenase; Provisional; Region: PRK15025 1048689001993 membrane protein FdrA; Validated; Region: PRK06091 1048689001994 CoA binding domain; Region: CoA_binding; pfam02629 1048689001995 CoA-ligase; Region: Ligase_CoA; pfam00549 1048689001996 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 1048689001997 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 1048689001998 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 1048689001999 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1048689002000 putative substrate binding site [chemical binding]; other site 1048689002001 nucleotide binding site [chemical binding]; other site 1048689002002 nucleotide binding site [chemical binding]; other site 1048689002003 homodimer interface [polypeptide binding]; other site 1048689002004 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1048689002005 ATP-grasp domain; Region: ATP-grasp; pfam02222 1048689002006 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1048689002007 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1048689002008 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1048689002009 putative active site [active] 1048689002010 putative metal binding site [ion binding]; other site 1048689002011 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1048689002012 substrate binding site [chemical binding]; other site 1048689002013 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1048689002014 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1048689002015 active site 1048689002016 HIGH motif; other site 1048689002017 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1048689002018 KMSKS motif; other site 1048689002019 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 1048689002020 tRNA binding surface [nucleotide binding]; other site 1048689002021 anticodon binding site; other site 1048689002022 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1048689002023 ribosome-associated protein; Provisional; Region: PRK11507 1048689002024 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 1048689002025 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1048689002026 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1048689002027 homodimer interface [polypeptide binding]; other site 1048689002028 NADP binding site [chemical binding]; other site 1048689002029 substrate binding site [chemical binding]; other site 1048689002030 type-1 fimbrial protein subunit A; Provisional; Region: PRK15194 1048689002031 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 1048689002032 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1048689002033 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1048689002034 outer membrane usher protein FimD; Provisional; Region: PRK15198 1048689002035 PapC N-terminal domain; Region: PapC_N; pfam13954 1048689002036 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1048689002037 PapC C-terminal domain; Region: PapC_C; pfam13953 1048689002038 fimbrial-like adhesin; Provisional; Region: fimH; PRK15199 1048689002039 fimbrial-like adhesin protein SfmF; Provisional; Region: PRK09934 1048689002040 transcriptional regulator FimZ; Provisional; Region: PRK09935 1048689002041 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1048689002042 active site 1048689002043 phosphorylation site [posttranslational modification] 1048689002044 intermolecular recognition site; other site 1048689002045 dimerization interface [polypeptide binding]; other site 1048689002046 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1048689002047 DNA binding residues [nucleotide binding] 1048689002048 dimerization interface [polypeptide binding]; other site 1048689002049 prophage Cp3 1048689002050 P22-like integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial and phage integrases, including those similar to phage P22-like integrases, DLP12 and APSE-1; Region: INT_P22_C; cd01192 1048689002051 Int/Topo IB signature motif; other site 1048689002052 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 1048689002053 DksA-like zinc finger domain containing protein; Region: PHA00080 1048689002054 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; cl05442 1048689002055 Protein of unknown function (DUF1317); Region: DUF1317; pfam07026 1048689002056 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 1048689002057 phage recombination protein Bet; Region: bet_lambda; TIGR01913 1048689002058 Host-nuclease inhibitor protein Gam; Region: Gam; pfam06064 1048689002059 FtsZ inhibitor protein; Reviewed; Region: kil; PRK11354 1048689002060 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1048689002061 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1048689002062 Predicted transcriptional regulator [Transcription]; Region: COG2932 1048689002063 sequence-specific DNA binding site [nucleotide binding]; other site 1048689002064 salt bridge; other site 1048689002065 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1048689002066 Catalytic site [active] 1048689002067 Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197 1048689002068 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 1048689002069 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 1048689002070 Replication protein P; Region: Phage_lambda_P; pfam06992 1048689002071 hypothetical protein; Provisional; Region: PRK09741 1048689002072 prophage protein NinE; Provisional; Region: PRK09689 1048689002073 Protein of unknown function (DUF1364); Region: DUF1364; pfam07102 1048689002074 endodeoxyribonuclease RUS; Reviewed; Region: PRK09786 1048689002075 Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323 1048689002076 The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes. But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736 1048689002077 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1048689002078 catalytic residue [active] 1048689002079 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 1048689002080 Bor protein; Region: Lambda_Bor; pfam06291 1048689002081 Protein of unknown function (DUF1398); Region: DUF1398; pfam07166 1048689002082 Phage DNA packaging protein Nu1; Region: Phage_Nu1; cl01720 1048689002083 Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471 1048689002084 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 1048689002085 gpW; Region: gpW; pfam02831 1048689002086 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 1048689002087 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 1048689002088 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 1048689002089 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1048689002090 tandem repeat interface [polypeptide binding]; other site 1048689002091 oligomer interface [polypeptide binding]; other site 1048689002092 active site residues [active] 1048689002093 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 1048689002094 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 1048689002095 DNA packaging protein FI; Region: Packaging_FI; pfam14000 1048689002096 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 1048689002097 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 1048689002098 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 1048689002099 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 1048689002100 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 1048689002101 phage minor tail protein G; Region: phage_lambda_G; TIGR01674 1048689002102 Minor tail protein T; Region: Phage_tail_T; pfam06223 1048689002103 Phage-related minor tail protein [Function unknown]; Region: COG5281 1048689002104 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 1048689002105 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 1048689002106 phage tail tape measure protein, lambda family; Region: tape_meas_lam_C; TIGR01541 1048689002107 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 1048689002108 Phage-related protein [Function unknown]; Region: COG4718 1048689002109 Phage-related protein [Function unknown]; Region: gp18; COG4672 1048689002110 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 1048689002111 MPN+ (JAMM) motif; other site 1048689002112 Zinc-binding site [ion binding]; other site 1048689002113 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1048689002114 NlpC/P60 family; Region: NLPC_P60; cl17555 1048689002115 Phage-related protein, tail component [Function unknown]; Region: COG4723 1048689002116 Phage-related protein, tail component [Function unknown]; Region: COG4733 1048689002117 Putative phage tail protein; Region: Phage-tail_3; pfam13550 1048689002118 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 1048689002119 Fibronectin type III protein; Region: DUF3672; pfam12421 1048689002120 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 1048689002121 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 1048689002122 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 1048689002123 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 1048689002124 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 1048689002125 Phage Tail Collar Domain; Region: Collar; pfam07484 1048689002126 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 1048689002127 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1048689002128 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1048689002129 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1048689002130 S-adenosylmethionine binding site [chemical binding]; other site 1048689002131 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1048689002132 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1048689002133 TAP-like protein; Region: Abhydrolase_4; pfam08386 1048689002134 outer membrane protease; Reviewed; Region: PRK10993 1048689002135 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1048689002136 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1048689002137 sequence-specific DNA binding site [nucleotide binding]; other site 1048689002138 salt bridge; other site 1048689002139 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1048689002140 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1048689002141 Coenzyme A binding pocket [chemical binding]; other site 1048689002142 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1048689002143 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1048689002144 hypothetical protein; Provisional; Region: PRK09936 1048689002145 bacteriophage N4 receptor, outer membrane subunit; Provisional; Region: PRK09782 1048689002146 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1048689002147 TPR motif; other site 1048689002148 binding surface 1048689002149 Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283 1048689002150 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 1048689002151 active site 1048689002152 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 1048689002153 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1048689002154 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1048689002155 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1048689002156 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1048689002157 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1048689002158 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1048689002159 RHS Repeat; Region: RHS_repeat; cl11982 1048689002160 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1048689002161 potential frameshift: common BLAST hit: gi|291281518|ref|YP_003498336.1| Rhs core protein with extension 1048689002162 Uncharacterized conserved protein [Function unknown]; Region: COG5435 1048689002163 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1048689002164 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1048689002165 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1048689002166 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 1048689002167 sensor kinase CusS; Provisional; Region: PRK09835 1048689002168 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1048689002169 dimerization interface [polypeptide binding]; other site 1048689002170 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1048689002171 dimer interface [polypeptide binding]; other site 1048689002172 phosphorylation site [posttranslational modification] 1048689002173 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1048689002174 ATP binding site [chemical binding]; other site 1048689002175 Mg2+ binding site [ion binding]; other site 1048689002176 G-X-G motif; other site 1048689002177 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 1048689002178 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1048689002179 active site 1048689002180 phosphorylation site [posttranslational modification] 1048689002181 intermolecular recognition site; other site 1048689002182 dimerization interface [polypeptide binding]; other site 1048689002183 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1048689002184 DNA binding site [nucleotide binding] 1048689002185 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 1048689002186 periplasmic copper-binding protein; Provisional; Region: PRK09838 1048689002187 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 1048689002188 HlyD family secretion protein; Region: HlyD_3; pfam13437 1048689002189 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 1048689002190 phenylalanine transporter; Provisional; Region: PRK10249 1048689002191 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1048689002192 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1048689002193 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1048689002194 dimer interface [polypeptide binding]; other site 1048689002195 FMN binding site [chemical binding]; other site 1048689002196 hypothetical protein; Provisional; Region: PRK10250 1048689002197 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 1048689002198 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 1048689002199 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1048689002200 Hok/gef family; Region: HOK_GEF; pfam01848 1048689002201 Hok/gef family; Region: HOK_GEF; pfam01848 1048689002202 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 1048689002203 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1048689002204 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 1048689002205 outer membrane receptor FepA; Provisional; Region: PRK13524 1048689002206 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1048689002207 N-terminal plug; other site 1048689002208 ligand-binding site [chemical binding]; other site 1048689002209 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 1048689002210 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 1048689002211 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1048689002212 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 1048689002213 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1048689002214 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1048689002215 acyl-activating enzyme (AAE) consensus motif; other site 1048689002216 AMP binding site [chemical binding]; other site 1048689002217 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1048689002218 LPS O-antigen length regulator; Provisional; Region: PRK10381 1048689002219 Chain length determinant protein; Region: Wzz; pfam02706 1048689002220 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1048689002221 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 1048689002222 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1048689002223 Walker A/P-loop; other site 1048689002224 ATP binding site [chemical binding]; other site 1048689002225 Q-loop/lid; other site 1048689002226 ABC transporter signature motif; other site 1048689002227 Walker B; other site 1048689002228 D-loop; other site 1048689002229 H-loop/switch region; other site 1048689002230 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1048689002231 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1048689002232 ABC-ATPase subunit interface; other site 1048689002233 dimer interface [polypeptide binding]; other site 1048689002234 putative PBP binding regions; other site 1048689002235 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1048689002236 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1048689002237 ABC-ATPase subunit interface; other site 1048689002238 dimer interface [polypeptide binding]; other site 1048689002239 putative PBP binding regions; other site 1048689002240 enterobactin exporter EntS; Provisional; Region: PRK10489 1048689002241 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689002242 putative substrate translocation pore; other site 1048689002243 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 1048689002244 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1048689002245 siderophore binding site; other site 1048689002246 isochorismate synthase EntC; Provisional; Region: PRK15016 1048689002247 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1048689002248 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 1048689002249 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1048689002250 acyl-activating enzyme (AAE) consensus motif; other site 1048689002251 active site 1048689002252 AMP binding site [chemical binding]; other site 1048689002253 substrate binding site [chemical binding]; other site 1048689002254 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 1048689002255 hydrophobic substrate binding pocket; other site 1048689002256 Isochorismatase family; Region: Isochorismatase; pfam00857 1048689002257 active site 1048689002258 conserved cis-peptide bond; other site 1048689002259 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1048689002260 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 1048689002261 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 1048689002262 putative NAD(P) binding site [chemical binding]; other site 1048689002263 active site 1048689002264 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1048689002265 CoenzymeA binding site [chemical binding]; other site 1048689002266 subunit interaction site [polypeptide binding]; other site 1048689002267 PHB binding site; other site 1048689002268 carbon starvation protein A; Provisional; Region: PRK15015 1048689002269 Carbon starvation protein CstA; Region: CstA; pfam02554 1048689002270 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1048689002271 Uncharacterized small protein [Function unknown]; Region: COG2879 1048689002272 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1048689002273 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 1048689002274 putative active site [active] 1048689002275 metal binding site [ion binding]; metal-binding site 1048689002276 methionine aminotransferase; Validated; Region: PRK09082 1048689002277 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1048689002278 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048689002279 homodimer interface [polypeptide binding]; other site 1048689002280 catalytic residue [active] 1048689002281 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1048689002282 ParB-like nuclease domain; Region: ParBc; pfam02195 1048689002283 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 1048689002284 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1048689002285 Active Sites [active] 1048689002286 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 1048689002287 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 1048689002288 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1048689002289 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1048689002290 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 1048689002291 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1048689002292 dimerization domain [polypeptide binding]; other site 1048689002293 dimer interface [polypeptide binding]; other site 1048689002294 catalytic residues [active] 1048689002295 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 1048689002296 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1048689002297 dimer interface [polypeptide binding]; other site 1048689002298 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1048689002299 catalytic triad [active] 1048689002300 peroxidatic and resolving cysteines [active] 1048689002301 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1048689002302 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1048689002303 catalytic residue [active] 1048689002304 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1048689002305 catalytic residues [active] 1048689002306 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1048689002307 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1048689002308 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1048689002309 Ligand Binding Site [chemical binding]; other site 1048689002310 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1048689002311 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1048689002312 NAD binding site [chemical binding]; other site 1048689002313 catalytic Zn binding site [ion binding]; other site 1048689002314 structural Zn binding site [ion binding]; other site 1048689002315 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 1048689002316 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1048689002317 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 1048689002318 B1 nucleotide binding pocket [chemical binding]; other site 1048689002319 B2 nucleotide binding pocket [chemical binding]; other site 1048689002320 CAS motifs; other site 1048689002321 active site 1048689002322 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1048689002323 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1048689002324 transmembrane helices; other site 1048689002325 triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096 1048689002326 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 1048689002327 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 1048689002328 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1048689002329 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 1048689002330 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 1048689002331 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 1048689002332 putative active site [active] 1048689002333 (T/H)XGH motif; other site 1048689002334 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 1048689002335 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1048689002336 putative active site [active] 1048689002337 heme pocket [chemical binding]; other site 1048689002338 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1048689002339 ATP binding site [chemical binding]; other site 1048689002340 Mg2+ binding site [ion binding]; other site 1048689002341 G-X-G motif; other site 1048689002342 two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046 1048689002343 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1048689002344 active site 1048689002345 phosphorylation site [posttranslational modification] 1048689002346 intermolecular recognition site; other site 1048689002347 dimerization interface [polypeptide binding]; other site 1048689002348 Transcriptional regulator; Region: CitT; pfam12431 1048689002349 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 1048689002350 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1048689002351 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 1048689002352 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1048689002353 DNA-binding site [nucleotide binding]; DNA binding site 1048689002354 RNA-binding motif; other site 1048689002355 chromosome condensation membrane protein; Provisional; Region: PRK14196 1048689002356 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1048689002357 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 1048689002358 putative active site [active] 1048689002359 catalytic triad [active] 1048689002360 putative dimer interface [polypeptide binding]; other site 1048689002361 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 1048689002362 lipoyl synthase; Provisional; Region: PRK05481 1048689002363 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1048689002364 FeS/SAM binding site; other site 1048689002365 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 1048689002366 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1048689002367 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1048689002368 substrate binding pocket [chemical binding]; other site 1048689002369 dimerization interface [polypeptide binding]; other site 1048689002370 lipoate-protein ligase B; Provisional; Region: PRK14342 1048689002371 hypothetical protein; Provisional; Region: PRK04998 1048689002372 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 1048689002373 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1048689002374 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1048689002375 rare lipoprotein A; Provisional; Region: PRK10672 1048689002376 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1048689002377 Sporulation related domain; Region: SPOR; pfam05036 1048689002378 cell wall shape-determining protein; Provisional; Region: PRK10794 1048689002379 penicillin-binding protein 2; Provisional; Region: PRK10795 1048689002380 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1048689002381 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1048689002382 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 1048689002383 ribosome-associated protein; Provisional; Region: PRK11538 1048689002384 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1048689002385 catalytic core [active] 1048689002386 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1048689002387 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1048689002388 active site 1048689002389 (T/H)XGH motif; other site 1048689002390 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1048689002391 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1048689002392 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 1048689002393 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1048689002394 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1048689002395 HIGH motif; other site 1048689002396 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1048689002397 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1048689002398 active site 1048689002399 KMSKS motif; other site 1048689002400 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1048689002401 tRNA binding surface [nucleotide binding]; other site 1048689002402 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1048689002403 hypothetical protein; Provisional; Region: PRK11032 1048689002404 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 1048689002405 Sel1-like repeats; Region: SEL1; smart00671 1048689002406 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1048689002407 Sel1-like repeats; Region: SEL1; smart00671 1048689002408 Sel1-like repeats; Region: SEL1; smart00671 1048689002409 Sel1-like repeats; Region: SEL1; smart00671 1048689002410 Sel1-like repeats; Region: SEL1; smart00671 1048689002411 Sel1-like repeats; Region: SEL1; smart00671 1048689002412 Sel1-like repeats; Region: SEL1; smart00671 1048689002413 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 1048689002414 DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271 1048689002415 HSP70 interaction site [polypeptide binding]; other site 1048689002416 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1048689002417 Sel1-like repeats; Region: SEL1; smart00671 1048689002418 Sel1-like repeats; Region: SEL1; smart00671 1048689002419 Sel1-like repeats; Region: SEL1; smart00671 1048689002420 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 1048689002421 potential frameshift: common BLAST hit: gi|218549775|ref|YP_002383566.1| Hsc56 co-chaperone of HscC 1048689002422 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 1048689002423 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 1048689002424 nucleotide binding site [chemical binding]; other site 1048689002425 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1048689002426 SBD interface [polypeptide binding]; other site 1048689002427 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1048689002428 active site 1048689002429 tetramer interface [polypeptide binding]; other site 1048689002430 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1048689002431 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1048689002432 Walker A/P-loop; other site 1048689002433 ATP binding site [chemical binding]; other site 1048689002434 Q-loop/lid; other site 1048689002435 ABC transporter signature motif; other site 1048689002436 Walker B; other site 1048689002437 D-loop; other site 1048689002438 H-loop/switch region; other site 1048689002439 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1048689002440 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048689002441 dimer interface [polypeptide binding]; other site 1048689002442 conserved gate region; other site 1048689002443 putative PBP binding loops; other site 1048689002444 ABC-ATPase subunit interface; other site 1048689002445 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1048689002446 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048689002447 dimer interface [polypeptide binding]; other site 1048689002448 conserved gate region; other site 1048689002449 putative PBP binding loops; other site 1048689002450 ABC-ATPase subunit interface; other site 1048689002451 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1048689002452 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1048689002453 substrate binding pocket [chemical binding]; other site 1048689002454 membrane-bound complex binding site; other site 1048689002455 hinge residues; other site 1048689002456 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1048689002457 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1048689002458 putative active site [active] 1048689002459 catalytic triad [active] 1048689002460 putative dimer interface [polypeptide binding]; other site 1048689002461 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 1048689002462 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1048689002463 Transporter associated domain; Region: CorC_HlyC; smart01091 1048689002464 metal-binding heat shock protein; Provisional; Region: PRK00016 1048689002465 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1048689002466 PhoH-like protein; Region: PhoH; pfam02562 1048689002467 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 1048689002468 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1048689002469 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1048689002470 FeS/SAM binding site; other site 1048689002471 TRAM domain; Region: TRAM; pfam01938 1048689002472 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 1048689002473 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1048689002474 asparagine synthetase B; Provisional; Region: asnB; PRK09431 1048689002475 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1048689002476 active site 1048689002477 dimer interface [polypeptide binding]; other site 1048689002478 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1048689002479 Ligand Binding Site [chemical binding]; other site 1048689002480 Molecular Tunnel; other site 1048689002481 UMP phosphatase; Provisional; Region: PRK10444 1048689002482 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1048689002483 active site 1048689002484 motif I; other site 1048689002485 motif II; other site 1048689002486 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1048689002487 MarR family; Region: MarR; pfam01047 1048689002488 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1048689002489 ROK family; Region: ROK; pfam00480 1048689002490 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 1048689002491 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1048689002492 active site 1048689002493 dimer interface [polypeptide binding]; other site 1048689002494 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1048689002495 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1048689002496 active site 1048689002497 trimer interface [polypeptide binding]; other site 1048689002498 allosteric site; other site 1048689002499 active site lid [active] 1048689002500 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1048689002501 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 1048689002502 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1048689002503 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1048689002504 active site turn [active] 1048689002505 phosphorylation site [posttranslational modification] 1048689002506 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1048689002507 HPr interaction site; other site 1048689002508 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1048689002509 active site 1048689002510 phosphorylation site [posttranslational modification] 1048689002511 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1048689002512 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1048689002513 active site 1048689002514 HIGH motif; other site 1048689002515 nucleotide binding site [chemical binding]; other site 1048689002516 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 1048689002517 KMSKS motif; other site 1048689002518 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1048689002519 outer membrane porin, OprD family; Region: OprD; pfam03573 1048689002520 ferric uptake regulator; Provisional; Region: fur; PRK09462 1048689002521 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1048689002522 metal binding site 2 [ion binding]; metal-binding site 1048689002523 putative DNA binding helix; other site 1048689002524 metal binding site 1 [ion binding]; metal-binding site 1048689002525 dimer interface [polypeptide binding]; other site 1048689002526 structural Zn2+ binding site [ion binding]; other site 1048689002527 flavodoxin FldA; Validated; Region: PRK09267 1048689002528 LexA regulated protein; Provisional; Region: PRK11675 1048689002529 acyl-CoA esterase; Provisional; Region: PRK10673 1048689002530 PGAP1-like protein; Region: PGAP1; pfam07819 1048689002531 replication initiation regulator SeqA; Provisional; Region: PRK11187 1048689002532 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 1048689002533 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1048689002534 active site 1048689002535 substrate binding site [chemical binding]; other site 1048689002536 metal binding site [ion binding]; metal-binding site 1048689002537 putrescine transporter; Provisional; Region: potE; PRK10655 1048689002538 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1048689002539 ornithine decarboxylase; Provisional; Region: PRK13578 1048689002540 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1048689002541 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1048689002542 homodimer interface [polypeptide binding]; other site 1048689002543 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048689002544 catalytic residue [active] 1048689002545 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1048689002546 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1048689002547 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1048689002548 active site 1048689002549 phosphorylation site [posttranslational modification] 1048689002550 intermolecular recognition site; other site 1048689002551 dimerization interface [polypeptide binding]; other site 1048689002552 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1048689002553 DNA binding site [nucleotide binding] 1048689002554 sensor protein KdpD; Provisional; Region: PRK10490 1048689002555 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1048689002556 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1048689002557 Ligand Binding Site [chemical binding]; other site 1048689002558 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1048689002559 GAF domain; Region: GAF_3; pfam13492 1048689002560 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1048689002561 dimer interface [polypeptide binding]; other site 1048689002562 phosphorylation site [posttranslational modification] 1048689002563 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1048689002564 ATP binding site [chemical binding]; other site 1048689002565 Mg2+ binding site [ion binding]; other site 1048689002566 G-X-G motif; other site 1048689002567 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 1048689002568 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1048689002569 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1048689002570 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1048689002571 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 1048689002572 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1048689002573 RHS protein; Region: RHS; pfam03527 1048689002574 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1048689002575 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1048689002576 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1048689002577 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1048689002578 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1048689002579 hypothetical protein; Provisional; Region: PRK10167 1048689002580 Uncharacterized conserved protein [Function unknown]; Region: COG3272 1048689002581 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 1048689002582 DNA photolyase; Region: DNA_photolyase; pfam00875 1048689002583 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1048689002584 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689002585 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689002586 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1048689002587 metal-binding protein; Provisional; Region: PRK10799 1048689002588 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1048689002589 sensor histidine kinase inhibitor, KipI family; Region: TIGR00370 1048689002590 biotin-dependent carboxylase uncharacterized domain; Region: urea_amlyse_rel; TIGR00724 1048689002591 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 1048689002592 putative active site [active] 1048689002593 endonuclease VIII; Provisional; Region: PRK10445 1048689002594 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 1048689002595 DNA binding site [nucleotide binding] 1048689002596 catalytic residue [active] 1048689002597 putative catalytic residues [active] 1048689002598 H2TH interface [polypeptide binding]; other site 1048689002599 intercalation triad [nucleotide binding]; other site 1048689002600 substrate specificity determining residue; other site 1048689002601 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1048689002602 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1048689002603 Putative ammonia monooxygenase; Region: AmoA; pfam05145 1048689002604 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1048689002605 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1048689002606 Fimbrial protein; Region: Fimbrial; pfam00419 1048689002607 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1048689002608 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1048689002609 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1048689002610 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1048689002611 PapC N-terminal domain; Region: PapC_N; pfam13954 1048689002612 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1048689002613 PapC C-terminal domain; Region: PapC_C; pfam13953 1048689002614 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1048689002615 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1048689002616 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1048689002617 dimer interface [polypeptide binding]; other site 1048689002618 active site 1048689002619 citrylCoA binding site [chemical binding]; other site 1048689002620 NADH binding [chemical binding]; other site 1048689002621 cationic pore residues; other site 1048689002622 oxalacetate/citrate binding site [chemical binding]; other site 1048689002623 coenzyme A binding site [chemical binding]; other site 1048689002624 catalytic triad [active] 1048689002625 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 1048689002626 Iron-sulfur protein interface; other site 1048689002627 proximal quinone binding site [chemical binding]; other site 1048689002628 SdhD (CybS) interface [polypeptide binding]; other site 1048689002629 proximal heme binding site [chemical binding]; other site 1048689002630 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 1048689002631 SdhC subunit interface [polypeptide binding]; other site 1048689002632 proximal heme binding site [chemical binding]; other site 1048689002633 cardiolipin binding site; other site 1048689002634 Iron-sulfur protein interface; other site 1048689002635 proximal quinone binding site [chemical binding]; other site 1048689002636 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 1048689002637 L-aspartate oxidase; Provisional; Region: PRK06175 1048689002638 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1048689002639 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1048689002640 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1048689002641 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 1048689002642 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1048689002643 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1048689002644 TPP-binding site [chemical binding]; other site 1048689002645 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1048689002646 dimer interface [polypeptide binding]; other site 1048689002647 PYR/PP interface [polypeptide binding]; other site 1048689002648 TPP binding site [chemical binding]; other site 1048689002649 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1048689002650 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1048689002651 E3 interaction surface; other site 1048689002652 lipoyl attachment site [posttranslational modification]; other site 1048689002653 e3 binding domain; Region: E3_binding; pfam02817 1048689002654 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1048689002655 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1048689002656 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1048689002657 CoA-ligase; Region: Ligase_CoA; pfam00549 1048689002658 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1048689002659 CoA binding domain; Region: CoA_binding; smart00881 1048689002660 CoA-ligase; Region: Ligase_CoA; pfam00549 1048689002661 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1048689002662 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1048689002663 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1048689002664 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1048689002665 dimerization interface [polypeptide binding]; other site 1048689002666 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1048689002667 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 1048689002668 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1048689002669 homodimer interface [polypeptide binding]; other site 1048689002670 Walker A motif; other site 1048689002671 ATP binding site [chemical binding]; other site 1048689002672 hydroxycobalamin binding site [chemical binding]; other site 1048689002673 Walker B motif; other site 1048689002674 putative fumarate hydratase; Provisional; Region: PRK15392 1048689002675 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 1048689002676 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1048689002677 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1048689002678 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1048689002679 Domain of unknown function (DUF4387); Region: DUF4387; pfam14330 1048689002680 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 1048689002681 Methylaspartate ammonia-lyase [Amino acid transport and metabolism]; Region: Mal; COG3799 1048689002682 Methylaspartate ammonia lyase (3-methylaspartase, MAL) is a homodimeric enzyme, catalyzing the magnesium-dependent reversible alpha,beta-elimination of ammonia from L-threo-(2S,3S)-3-methylaspartic acid to mesaconic acid. This reaction is part of the...; Region: MAL; cd03314 1048689002683 dimer interface [polypeptide binding]; other site 1048689002684 active site 1048689002685 Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to...; Region: Glm_e; cd00245 1048689002686 substrate binding site [chemical binding]; other site 1048689002687 B12 cofactor binding site [chemical binding]; other site 1048689002688 heterodimer (sigma-epsilon) interface [polypeptide binding]; other site 1048689002689 homodimer (epsilon-epsilon) interface [polypeptide binding]; other site 1048689002690 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1048689002691 conserved hypothetical protein; Region: glmL_fam; TIGR01319 1048689002692 nucleotide binding site [chemical binding]; other site 1048689002693 B12 binding domain of glutamate mutase (Glm). Glutamate mutase catalysis the conversion of (S)-glutamate with (2S,3S)-3-methylaspartate. The rearrangement reaction is initiated by the extraction of a hydrogen from the protein-bound substrate by a 5'...; Region: Glm_B12_BD; cd02072 1048689002694 B12 binding site [chemical binding]; other site 1048689002695 heterodimer interface [polypeptide binding]; other site 1048689002696 cobalt ligand [ion binding]; other site 1048689002697 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1048689002698 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 1048689002699 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 1048689002700 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 1048689002701 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 1048689002702 hypothetical protein; Provisional; Region: PRK10588 1048689002703 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1048689002704 active site 1048689002705 colicin uptake protein TolQ; Provisional; Region: PRK10801 1048689002706 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1048689002707 colicin uptake protein TolR; Provisional; Region: PRK11024 1048689002708 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 1048689002709 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 1048689002710 TolA C-terminal; Region: TolA; pfam06519 1048689002711 translocation protein TolB; Provisional; Region: tolB; PRK03629 1048689002712 TolB amino-terminal domain; Region: TolB_N; pfam04052 1048689002713 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1048689002714 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1048689002715 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1048689002716 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 1048689002717 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1048689002718 ligand binding site [chemical binding]; other site 1048689002719 tol-pal system protein YbgF; Provisional; Region: PRK10803 1048689002720 Tetratricopeptide repeat; Region: TPR_6; pfam13174 1048689002721 Tetratricopeptide repeat; Region: TPR_6; pfam13174 1048689002722 quinolinate synthetase; Provisional; Region: PRK09375 1048689002723 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 1048689002724 zinc transporter ZitB; Provisional; Region: PRK03557 1048689002725 YbgS-like protein; Region: YbgS; pfam13985 1048689002726 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1048689002727 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1048689002728 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1048689002729 catalytic core [active] 1048689002730 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1048689002731 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1048689002732 active site 1048689002733 catalytic residues [active] 1048689002734 galactokinase; Provisional; Region: PRK05101 1048689002735 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1048689002736 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1048689002737 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 1048689002738 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 1048689002739 dimer interface [polypeptide binding]; other site 1048689002740 active site 1048689002741 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 1048689002742 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1048689002743 NAD binding site [chemical binding]; other site 1048689002744 homodimer interface [polypeptide binding]; other site 1048689002745 active site 1048689002746 substrate binding site [chemical binding]; other site 1048689002747 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 1048689002748 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 1048689002749 Walker A/P-loop; other site 1048689002750 ATP binding site [chemical binding]; other site 1048689002751 Q-loop/lid; other site 1048689002752 ABC transporter signature motif; other site 1048689002753 Walker B; other site 1048689002754 D-loop; other site 1048689002755 H-loop/switch region; other site 1048689002756 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1048689002757 Walker A/P-loop; other site 1048689002758 ATP binding site [chemical binding]; other site 1048689002759 Q-loop/lid; other site 1048689002760 ABC transporter signature motif; other site 1048689002761 Walker B; other site 1048689002762 D-loop; other site 1048689002763 H-loop/switch region; other site 1048689002764 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 1048689002765 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 1048689002766 molybdenum-pterin binding domain; Region: Mop; TIGR00638 1048689002767 TOBE domain; Region: TOBE; pfam03459 1048689002768 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 1048689002769 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 1048689002770 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1048689002771 substrate binding pocket [chemical binding]; other site 1048689002772 membrane-bound complex binding site; other site 1048689002773 hinge residues; other site 1048689002774 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1048689002775 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048689002776 putative PBP binding loops; other site 1048689002777 ABC-ATPase subunit interface; other site 1048689002778 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 1048689002779 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1048689002780 Walker A/P-loop; other site 1048689002781 ATP binding site [chemical binding]; other site 1048689002782 Q-loop/lid; other site 1048689002783 ABC transporter signature motif; other site 1048689002784 Walker B; other site 1048689002785 D-loop; other site 1048689002786 H-loop/switch region; other site 1048689002787 molybdenum-pterin binding domain; Region: Mop; TIGR00638 1048689002788 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 1048689002789 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1048689002790 motif II; other site 1048689002791 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1048689002792 6-phosphogluconolactonase; Provisional; Region: PRK11028 1048689002793 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1048689002794 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1048689002795 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1048689002796 putative dimerization interface [polypeptide binding]; other site 1048689002797 PrpF protein; Region: PrpF; pfam04303 1048689002798 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1048689002799 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1048689002800 transmembrane helices; other site 1048689002801 putative hydratase; Provisional; Region: PRK11413 1048689002802 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1048689002803 substrate binding site [chemical binding]; other site 1048689002804 ligand binding site [chemical binding]; other site 1048689002805 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 1048689002806 substrate binding site [chemical binding]; other site 1048689002807 acyl-CoA thioesterase; Provisional; Region: PRK10531 1048689002808 putative pectinesterase; Region: PLN02432; cl01911 1048689002809 prophage Cp4 1048689002810 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 1048689002811 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 1048689002812 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1048689002813 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 1048689002814 dimer interface [polypeptide binding]; other site 1048689002815 active site 1048689002816 Int/Topo IB signature motif; other site 1048689002817 Excisionase-like protein; Region: Exc; pfam07825 1048689002818 DksA-like zinc finger domain containing protein; Region: PHA00080 1048689002819 Protein of unknown function (DUF1382); Region: DUF1382; pfam07131 1048689002820 Protein of unknown function (DUF1317); Region: DUF1317; pfam07026 1048689002821 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 1048689002822 phage recombination protein Bet; Region: bet_lambda; TIGR01913 1048689002823 Host-nuclease inhibitor protein Gam; Region: Gam; pfam06064 1048689002824 Bacteriophage lambda Kil protein; Region: Lambda_Kil; pfam06301 1048689002825 Antirestriction protein Ral; Region: Ral; pfam11058 1048689002826 Superinfection exclusion protein B; Region: SieB; pfam14163 1048689002827 36-mer N-terminal peptide of the N protein (N36); Region: N36; pfam11438 1048689002828 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1048689002829 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1048689002830 non-specific DNA binding site [nucleotide binding]; other site 1048689002831 salt bridge; other site 1048689002832 sequence-specific DNA binding site [nucleotide binding]; other site 1048689002833 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1048689002834 Catalytic site [active] 1048689002835 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1048689002836 sequence-specific DNA binding site [nucleotide binding]; other site 1048689002837 salt bridge; other site 1048689002838 Bacteriophage CII protein; Region: Phage_CII; pfam05269 1048689002839 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 1048689002840 Replication protein P; Region: Phage_lambda_P; pfam06992 1048689002841 NinB protein; Region: NinB; pfam05772 1048689002842 NINE Protein; Region: NinE; pfam05322 1048689002843 NinF protein; Region: NinF; pfam05810 1048689002844 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 1048689002845 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 1048689002846 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1048689002847 active site 1048689002848 metal binding site [ion binding]; metal-binding site 1048689002849 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3528 1048689002850 Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323 1048689002851 Protein of unknown function (DUF3927); Region: DUF3927; pfam13064 1048689002852 Lysis protein S; Region: Lysis_S; pfam04971 1048689002853 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1048689002854 catalytic residues [active] 1048689002855 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 1048689002856 Protein of unknown function (DUF1441); Region: DUF1441; pfam07278 1048689002857 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 1048689002858 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1048689002859 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 1048689002860 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 1048689002861 potential frameshift: common BLAST hit: gi|254791946|ref|YP_003076783.1| putative protease encoded in prophage CP-933K 1048689002862 Uncharacterized conserved protein [Function unknown]; Region: COG5471 1048689002863 ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; pfam13856 1048689002864 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 1048689002865 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 1048689002866 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 1048689002867 Bacterial Ig-like domain 2; Region: BID_2; smart00635 1048689002868 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; cl06106 1048689002869 Minor tail protein T; Region: Phage_tail_T; pfam06223 1048689002870 Phage-related minor tail protein [Function unknown]; Region: COG5281 1048689002871 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 1048689002872 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 1048689002873 Phage-related protein [Function unknown]; Region: COG4718 1048689002874 Phage-related protein [Function unknown]; Region: gp18; COG4672 1048689002875 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 1048689002876 MPN+ (JAMM) motif; other site 1048689002877 Zinc-binding site [ion binding]; other site 1048689002878 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1048689002879 NlpC/P60 family; Region: NLPC_P60; cl17555 1048689002880 Phage-related protein, tail component [Function unknown]; Region: COG4723 1048689002881 Phage-related protein, tail component [Function unknown]; Region: COG4733 1048689002882 Putative phage tail protein; Region: Phage-tail_3; pfam13550 1048689002883 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 1048689002884 Fibronectin type III protein; Region: DUF3672; pfam12421 1048689002885 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 1048689002886 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 1048689002887 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 1048689002888 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 1048689002889 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 1048689002890 non-LEE encoded effector protein NleB; Provisional; Region: PRK15382 1048689002891 type III secretion system protein; Provisional; Region: PRK15384; cl14665 1048689002892 NFkB-p65-degrading zinc protease; Region: Peptidase_M85; pfam13678 1048689002893 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1048689002894 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512 1048689002895 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1048689002896 substrate binding site [chemical binding]; other site 1048689002897 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 1048689002898 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1048689002899 inhibitor-cofactor binding pocket; inhibition site 1048689002900 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048689002901 catalytic residue [active] 1048689002902 biotin synthase; Provisional; Region: PRK15108 1048689002903 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1048689002904 FeS/SAM binding site; other site 1048689002905 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 1048689002906 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1048689002907 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1048689002908 substrate-cofactor binding pocket; other site 1048689002909 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048689002910 catalytic residue [active] 1048689002911 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 1048689002912 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1048689002913 S-adenosylmethionine binding site [chemical binding]; other site 1048689002914 AAA domain; Region: AAA_26; pfam13500 1048689002915 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1048689002916 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 1048689002917 ADP binding site [chemical binding]; other site 1048689002918 excinuclease ABC subunit B; Provisional; Region: PRK05298 1048689002919 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1048689002920 ATP binding site [chemical binding]; other site 1048689002921 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1048689002922 nucleotide binding region [chemical binding]; other site 1048689002923 ATP-binding site [chemical binding]; other site 1048689002924 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1048689002925 UvrB/uvrC motif; Region: UVR; pfam02151 1048689002926 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1048689002927 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1048689002928 putative substrate binding pocket [chemical binding]; other site 1048689002929 dimer interface [polypeptide binding]; other site 1048689002930 phosphate binding site [ion binding]; other site 1048689002931 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1048689002932 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1048689002933 FeS/SAM binding site; other site 1048689002934 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1048689002935 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1048689002936 MPT binding site; other site 1048689002937 trimer interface [polypeptide binding]; other site 1048689002938 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1048689002939 trimer interface [polypeptide binding]; other site 1048689002940 dimer interface [polypeptide binding]; other site 1048689002941 putative active site [active] 1048689002942 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1048689002943 MoaE interaction surface [polypeptide binding]; other site 1048689002944 MoeB interaction surface [polypeptide binding]; other site 1048689002945 thiocarboxylated glycine; other site 1048689002946 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1048689002947 MoaE homodimer interface [polypeptide binding]; other site 1048689002948 MoaD interaction [polypeptide binding]; other site 1048689002949 active site residues [active] 1048689002950 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1048689002951 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1048689002952 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1048689002953 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1048689002954 Predicted integral membrane protein [Function unknown]; Region: COG0392 1048689002955 cardiolipin synthase 2; Provisional; Region: PRK11263 1048689002956 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1048689002957 putative active site [active] 1048689002958 catalytic site [active] 1048689002959 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 1048689002960 putative active site [active] 1048689002961 catalytic site [active] 1048689002962 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 1048689002963 putative catalytic site [active] 1048689002964 putative metal binding site [ion binding]; other site 1048689002965 putative phosphate binding site [ion binding]; other site 1048689002966 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 1048689002967 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1048689002968 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1048689002969 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1048689002970 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1048689002971 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1048689002972 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1048689002973 Walker A/P-loop; other site 1048689002974 ATP binding site [chemical binding]; other site 1048689002975 Q-loop/lid; other site 1048689002976 ABC transporter signature motif; other site 1048689002977 Walker B; other site 1048689002978 D-loop; other site 1048689002979 H-loop/switch region; other site 1048689002980 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1048689002981 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1048689002982 Walker A/P-loop; other site 1048689002983 ATP binding site [chemical binding]; other site 1048689002984 Q-loop/lid; other site 1048689002985 ABC transporter signature motif; other site 1048689002986 Walker B; other site 1048689002987 D-loop; other site 1048689002988 H-loop/switch region; other site 1048689002989 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 1048689002990 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1048689002991 HlyD family secretion protein; Region: HlyD_3; pfam13437 1048689002992 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 1048689002993 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 1048689002994 helicase 45; Provisional; Region: PTZ00424 1048689002995 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1048689002996 ATP binding site [chemical binding]; other site 1048689002997 Mg++ binding site [ion binding]; other site 1048689002998 motif III; other site 1048689002999 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1048689003000 nucleotide binding region [chemical binding]; other site 1048689003001 ATP-binding site [chemical binding]; other site 1048689003002 SopA-like central domain; Region: SopA; pfam13981 1048689003003 SopA-like catalytic domain; Region: SopA_C; pfam13979 1048689003004 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 1048689003005 DEAD_2; Region: DEAD_2; pfam06733 1048689003006 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1048689003007 glycosyl transferase family protein; Provisional; Region: PRK08136 1048689003008 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1048689003009 putative dehydrogenase; Provisional; Region: PRK10098 1048689003010 hypothetical protein; Provisional; Region: PRK10259 1048689003011 hypothetical protein; Provisional; Region: PRK11019 1048689003012 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 1048689003013 catecholate siderophore receptor Fiu; Provisional; Region: PRK09840 1048689003014 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1048689003015 N-terminal plug; other site 1048689003016 ligand-binding site [chemical binding]; other site 1048689003017 hypothetical protein; Provisional; Region: PRK10259 1048689003018 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 1048689003019 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 1048689003020 putative mechanosensitive channel protein; Provisional; Region: PRK11465 1048689003021 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1048689003022 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 1048689003023 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1048689003024 Walker A/P-loop; other site 1048689003025 ATP binding site [chemical binding]; other site 1048689003026 Q-loop/lid; other site 1048689003027 ABC transporter signature motif; other site 1048689003028 Walker B; other site 1048689003029 D-loop; other site 1048689003030 H-loop/switch region; other site 1048689003031 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1048689003032 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048689003033 dimer interface [polypeptide binding]; other site 1048689003034 conserved gate region; other site 1048689003035 putative PBP binding loops; other site 1048689003036 ABC-ATPase subunit interface; other site 1048689003037 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 1048689003038 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1048689003039 substrate binding pocket [chemical binding]; other site 1048689003040 membrane-bound complex binding site; other site 1048689003041 hinge residues; other site 1048689003042 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1048689003043 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1048689003044 dimerization interface [polypeptide binding]; other site 1048689003045 DPS ferroxidase diiron center [ion binding]; other site 1048689003046 ion pore; other site 1048689003047 threonine and homoserine efflux system; Provisional; Region: PRK10532 1048689003048 EamA-like transporter family; Region: EamA; pfam00892 1048689003049 outer membrane protein X; Provisional; Region: ompX; PRK09408 1048689003050 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 1048689003051 Sulfatase; Region: Sulfatase; pfam00884 1048689003052 manganese transport regulator MntR; Provisional; Region: PRK11050 1048689003053 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1048689003054 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1048689003055 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1048689003056 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 1048689003057 transmembrane helices; other site 1048689003058 L,D-transpeptidase; Provisional; Region: PRK10260 1048689003059 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1048689003060 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1048689003061 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1048689003062 Walker A/P-loop; other site 1048689003063 ATP binding site [chemical binding]; other site 1048689003064 Q-loop/lid; other site 1048689003065 ABC transporter signature motif; other site 1048689003066 Walker B; other site 1048689003067 D-loop; other site 1048689003068 H-loop/switch region; other site 1048689003069 ABC transporter; Region: ABC_tran_2; pfam12848 1048689003070 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1048689003071 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 1048689003072 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 1048689003073 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1048689003074 active site 1048689003075 motif I; other site 1048689003076 motif II; other site 1048689003077 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1048689003078 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 1048689003079 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 1048689003080 dimer interface [polypeptide binding]; other site 1048689003081 active site 1048689003082 glycine loop; other site 1048689003083 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 1048689003084 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1048689003085 active site 1048689003086 intersubunit interactions; other site 1048689003087 catalytic residue [active] 1048689003088 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 1048689003089 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1048689003090 ATP binding site [chemical binding]; other site 1048689003091 substrate interface [chemical binding]; other site 1048689003092 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 1048689003093 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1048689003094 dimer interface [polypeptide binding]; other site 1048689003095 putative functional site; other site 1048689003096 putative MPT binding site; other site 1048689003097 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 1048689003098 catalytic nucleophile [active] 1048689003099 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 1048689003100 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1048689003101 Walker A/P-loop; other site 1048689003102 ATP binding site [chemical binding]; other site 1048689003103 Q-loop/lid; other site 1048689003104 ABC transporter signature motif; other site 1048689003105 Walker B; other site 1048689003106 D-loop; other site 1048689003107 H-loop/switch region; other site 1048689003108 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1048689003109 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1048689003110 Walker A/P-loop; other site 1048689003111 ATP binding site [chemical binding]; other site 1048689003112 Q-loop/lid; other site 1048689003113 ABC transporter signature motif; other site 1048689003114 Walker B; other site 1048689003115 D-loop; other site 1048689003116 H-loop/switch region; other site 1048689003117 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1048689003118 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 1048689003119 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 1048689003120 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 1048689003121 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048689003122 dimer interface [polypeptide binding]; other site 1048689003123 conserved gate region; other site 1048689003124 putative PBP binding loops; other site 1048689003125 ABC-ATPase subunit interface; other site 1048689003126 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 1048689003127 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1048689003128 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048689003129 dimer interface [polypeptide binding]; other site 1048689003130 conserved gate region; other site 1048689003131 putative PBP binding loops; other site 1048689003132 ABC-ATPase subunit interface; other site 1048689003133 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1048689003134 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1048689003135 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1048689003136 metal binding site [ion binding]; metal-binding site 1048689003137 active site 1048689003138 I-site; other site 1048689003139 Predicted transcriptional regulator [Transcription]; Region: COG2944 1048689003140 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1048689003141 non-specific DNA binding site [nucleotide binding]; other site 1048689003142 salt bridge; other site 1048689003143 sequence-specific DNA binding site [nucleotide binding]; other site 1048689003144 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4737 1048689003145 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 1048689003146 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1048689003147 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1048689003148 FeS/SAM binding site; other site 1048689003149 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 1048689003150 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1048689003151 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1048689003152 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1048689003153 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 1048689003154 putative C-terminal domain interface [polypeptide binding]; other site 1048689003155 putative GSH binding site (G-site) [chemical binding]; other site 1048689003156 putative dimer interface [polypeptide binding]; other site 1048689003157 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1048689003158 N-terminal domain interface [polypeptide binding]; other site 1048689003159 dimer interface [polypeptide binding]; other site 1048689003160 substrate binding pocket (H-site) [chemical binding]; other site 1048689003161 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 1048689003162 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1048689003163 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1048689003164 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 1048689003165 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1048689003166 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1048689003167 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 1048689003168 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1048689003169 active site 1048689003170 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 1048689003171 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689003172 putative substrate translocation pore; other site 1048689003173 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1048689003174 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1048689003175 active site 1048689003176 motif I; other site 1048689003177 motif II; other site 1048689003178 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1048689003179 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1048689003180 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689003181 putative substrate translocation pore; other site 1048689003182 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1048689003183 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1048689003184 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1048689003185 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1048689003186 putative transporter; Provisional; Region: PRK04972 1048689003187 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1048689003188 TrkA-C domain; Region: TrkA_C; pfam02080 1048689003189 TrkA-C domain; Region: TrkA_C; pfam02080 1048689003190 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 1048689003191 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 1048689003192 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 1048689003193 GSH binding site [chemical binding]; other site 1048689003194 catalytic residues [active] 1048689003195 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 1048689003196 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1048689003197 dimer interface [polypeptide binding]; other site 1048689003198 FMN binding site [chemical binding]; other site 1048689003199 NADPH bind site [chemical binding]; other site 1048689003200 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 1048689003201 RimK-like ATP-grasp domain; Region: RimK; pfam08443 1048689003202 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1048689003203 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1048689003204 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1048689003205 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 1048689003206 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1048689003207 Walker A/P-loop; other site 1048689003208 ATP binding site [chemical binding]; other site 1048689003209 Q-loop/lid; other site 1048689003210 ABC transporter signature motif; other site 1048689003211 Walker B; other site 1048689003212 D-loop; other site 1048689003213 H-loop/switch region; other site 1048689003214 TOBE domain; Region: TOBE_2; pfam08402 1048689003215 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1048689003216 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048689003217 dimer interface [polypeptide binding]; other site 1048689003218 conserved gate region; other site 1048689003219 putative PBP binding loops; other site 1048689003220 ABC-ATPase subunit interface; other site 1048689003221 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1048689003222 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048689003223 dimer interface [polypeptide binding]; other site 1048689003224 conserved gate region; other site 1048689003225 putative PBP binding loops; other site 1048689003226 ABC-ATPase subunit interface; other site 1048689003227 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 1048689003228 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 1048689003229 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1048689003230 S-adenosylmethionine binding site [chemical binding]; other site 1048689003231 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 1048689003232 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1048689003233 active site 1048689003234 P-loop; other site 1048689003235 phosphorylation site [posttranslational modification] 1048689003236 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1048689003237 Sulfatase; Region: Sulfatase; cl17466 1048689003238 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 1048689003239 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1048689003240 substrate binding pocket [chemical binding]; other site 1048689003241 membrane-bound complex binding site; other site 1048689003242 hinge residues; other site 1048689003243 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048689003244 dimer interface [polypeptide binding]; other site 1048689003245 conserved gate region; other site 1048689003246 putative PBP binding loops; other site 1048689003247 ABC-ATPase subunit interface; other site 1048689003248 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1048689003249 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048689003250 dimer interface [polypeptide binding]; other site 1048689003251 conserved gate region; other site 1048689003252 putative PBP binding loops; other site 1048689003253 ABC-ATPase subunit interface; other site 1048689003254 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 1048689003255 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1048689003256 substrate binding pocket [chemical binding]; other site 1048689003257 membrane-bound complex binding site; other site 1048689003258 hinge residues; other site 1048689003259 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 1048689003260 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1048689003261 Walker A/P-loop; other site 1048689003262 ATP binding site [chemical binding]; other site 1048689003263 Q-loop/lid; other site 1048689003264 ABC transporter signature motif; other site 1048689003265 Walker B; other site 1048689003266 D-loop; other site 1048689003267 H-loop/switch region; other site 1048689003268 putative lipoprotein; Provisional; Region: PRK10533 1048689003269 hypothetical protein; Provisional; Region: PRK02877 1048689003270 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1048689003271 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1048689003272 amidase catalytic site [active] 1048689003273 Zn binding residues [ion binding]; other site 1048689003274 substrate binding site [chemical binding]; other site 1048689003275 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1048689003276 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1048689003277 NAD(P) binding site [chemical binding]; other site 1048689003278 active site 1048689003279 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1048689003280 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 1048689003281 putative NAD(P) binding site [chemical binding]; other site 1048689003282 putative active site [active] 1048689003283 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 1048689003284 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1048689003285 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 1048689003286 tetramer interface [polypeptide binding]; other site 1048689003287 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048689003288 catalytic residue [active] 1048689003289 pyruvate dehydrogenase; Provisional; Region: PRK09124 1048689003290 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1048689003291 PYR/PP interface [polypeptide binding]; other site 1048689003292 dimer interface [polypeptide binding]; other site 1048689003293 tetramer interface [polypeptide binding]; other site 1048689003294 TPP binding site [chemical binding]; other site 1048689003295 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1048689003296 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1048689003297 TPP-binding site [chemical binding]; other site 1048689003298 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 1048689003299 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 1048689003300 FAD binding pocket [chemical binding]; other site 1048689003301 FAD binding motif [chemical binding]; other site 1048689003302 phosphate binding motif [ion binding]; other site 1048689003303 beta-alpha-beta structure motif; other site 1048689003304 NAD binding pocket [chemical binding]; other site 1048689003305 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1048689003306 catalytic loop [active] 1048689003307 iron binding site [ion binding]; other site 1048689003308 hybrid cluster protein; Provisional; Region: PRK05290 1048689003309 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1048689003310 ACS interaction site; other site 1048689003311 CODH interaction site; other site 1048689003312 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 1048689003313 hybrid metal cluster; other site 1048689003314 Predicted membrane protein [Function unknown]; Region: COG2431 1048689003315 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1048689003316 amphipathic channel; other site 1048689003317 Asn-Pro-Ala signature motifs; other site 1048689003318 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 1048689003319 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 1048689003320 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 1048689003321 putative active site [active] 1048689003322 putative metal-binding site [ion binding]; other site 1048689003323 Protein of unknown function (DUF535); Region: DUF535; pfam04393 1048689003324 macrolide transporter subunit MacA; Provisional; Region: PRK11578 1048689003325 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1048689003326 HlyD family secretion protein; Region: HlyD_3; pfam13437 1048689003327 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 1048689003328 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1048689003329 Walker A/P-loop; other site 1048689003330 ATP binding site [chemical binding]; other site 1048689003331 Q-loop/lid; other site 1048689003332 ABC transporter signature motif; other site 1048689003333 Walker B; other site 1048689003334 D-loop; other site 1048689003335 H-loop/switch region; other site 1048689003336 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1048689003337 FtsX-like permease family; Region: FtsX; pfam02687 1048689003338 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1048689003339 DNA-binding site [nucleotide binding]; DNA binding site 1048689003340 RNA-binding motif; other site 1048689003341 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1048689003342 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 1048689003343 Clp amino terminal domain; Region: Clp_N; pfam02861 1048689003344 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1048689003345 Walker A motif; other site 1048689003346 ATP binding site [chemical binding]; other site 1048689003347 Walker B motif; other site 1048689003348 arginine finger; other site 1048689003349 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1048689003350 Walker A motif; other site 1048689003351 ATP binding site [chemical binding]; other site 1048689003352 Walker B motif; other site 1048689003353 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1048689003354 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1048689003355 rRNA binding site [nucleotide binding]; other site 1048689003356 predicted 30S ribosome binding site; other site 1048689003357 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 1048689003358 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 1048689003359 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1048689003360 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 1048689003361 Walker A/P-loop; other site 1048689003362 ATP binding site [chemical binding]; other site 1048689003363 Q-loop/lid; other site 1048689003364 ABC transporter signature motif; other site 1048689003365 Walker B; other site 1048689003366 D-loop; other site 1048689003367 H-loop/switch region; other site 1048689003368 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 1048689003369 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1048689003370 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1048689003371 Walker A/P-loop; other site 1048689003372 ATP binding site [chemical binding]; other site 1048689003373 Q-loop/lid; other site 1048689003374 ABC transporter signature motif; other site 1048689003375 Walker B; other site 1048689003376 D-loop; other site 1048689003377 H-loop/switch region; other site 1048689003378 thioredoxin reductase; Provisional; Region: PRK10262 1048689003379 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1048689003380 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1048689003381 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 1048689003382 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1048689003383 putative DNA binding site [nucleotide binding]; other site 1048689003384 putative Zn2+ binding site [ion binding]; other site 1048689003385 AsnC family; Region: AsnC_trans_reg; pfam01037 1048689003386 DNA translocase FtsK; Provisional; Region: PRK10263 1048689003387 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1048689003388 DNA translocase FtsK; Provisional; Region: PRK10263 1048689003389 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1048689003390 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1048689003391 periplasmic chaperone LolA; Region: lolA; TIGR00547 1048689003392 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 1048689003393 recombination factor protein RarA; Reviewed; Region: PRK13342 1048689003394 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1048689003395 Walker A motif; other site 1048689003396 ATP binding site [chemical binding]; other site 1048689003397 Walker B motif; other site 1048689003398 arginine finger; other site 1048689003399 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1048689003400 seryl-tRNA synthetase; Provisional; Region: PRK05431 1048689003401 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1048689003402 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1048689003403 dimer interface [polypeptide binding]; other site 1048689003404 active site 1048689003405 motif 1; other site 1048689003406 motif 2; other site 1048689003407 motif 3; other site 1048689003408 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 1048689003409 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 1048689003410 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1048689003411 putative [Fe4-S4] binding site [ion binding]; other site 1048689003412 putative molybdopterin cofactor binding site [chemical binding]; other site 1048689003413 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1048689003414 putative molybdopterin cofactor binding site; other site 1048689003415 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1048689003416 4Fe-4S binding domain; Region: Fer4; pfam00037 1048689003417 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 1048689003418 Isochorismatase family; Region: Isochorismatase; pfam00857 1048689003419 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1048689003420 catalytic triad [active] 1048689003421 dimer interface [polypeptide binding]; other site 1048689003422 conserved cis-peptide bond; other site 1048689003423 putative MFS family transporter protein; Provisional; Region: PRK03633 1048689003424 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689003425 putative substrate translocation pore; other site 1048689003426 Amino acid permease; Region: AA_permease_2; pfam13520 1048689003427 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 1048689003428 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1048689003429 FeS/SAM binding site; other site 1048689003430 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1048689003431 Pyruvate formate lyase 1; Region: PFL1; cd01678 1048689003432 coenzyme A binding site [chemical binding]; other site 1048689003433 active site 1048689003434 catalytic residues [active] 1048689003435 glycine loop; other site 1048689003436 formate transporter; Provisional; Region: PRK10805 1048689003437 uncharacterized domain; Region: TIGR00702 1048689003438 YcaO-like family; Region: YcaO; pfam02624 1048689003439 Predicted membrane protein [Function unknown]; Region: COG2323 1048689003440 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1048689003441 homodimer interface [polypeptide binding]; other site 1048689003442 substrate-cofactor binding pocket; other site 1048689003443 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048689003444 catalytic residue [active] 1048689003445 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1048689003446 Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554 1048689003447 hinge; other site 1048689003448 active site 1048689003449 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1048689003450 cytidylate kinase; Provisional; Region: cmk; PRK00023 1048689003451 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1048689003452 CMP-binding site; other site 1048689003453 The sites determining sugar specificity; other site 1048689003454 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1048689003455 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1048689003456 RNA binding site [nucleotide binding]; other site 1048689003457 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1048689003458 RNA binding site [nucleotide binding]; other site 1048689003459 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 1048689003460 RNA binding site [nucleotide binding]; other site 1048689003461 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 1048689003462 RNA binding site [nucleotide binding]; other site 1048689003463 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 1048689003464 RNA binding site [nucleotide binding]; other site 1048689003465 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1048689003466 IHF dimer interface [polypeptide binding]; other site 1048689003467 IHF - DNA interface [nucleotide binding]; other site 1048689003468 ComEC family competence protein; Provisional; Region: PRK11539 1048689003469 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1048689003470 ComEC/Rec2-related protein; Region: ComEC_N-term; TIGR00360 1048689003471 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1048689003472 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 1048689003473 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1048689003474 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1048689003475 Walker A/P-loop; other site 1048689003476 ATP binding site [chemical binding]; other site 1048689003477 Q-loop/lid; other site 1048689003478 ABC transporter signature motif; other site 1048689003479 Walker B; other site 1048689003480 D-loop; other site 1048689003481 H-loop/switch region; other site 1048689003482 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 1048689003483 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 1048689003484 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1048689003485 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1048689003486 hypothetical protein; Provisional; Region: PRK11827 1048689003487 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1048689003488 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1048689003489 Ligand binding site; other site 1048689003490 oligomer interface; other site 1048689003491 hypothetical protein; Provisional; Region: PRK10593 1048689003492 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1048689003493 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1048689003494 putative active site [active] 1048689003495 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1048689003496 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1048689003497 S-adenosylmethionine binding site [chemical binding]; other site 1048689003498 condesin subunit F; Provisional; Region: PRK05260 1048689003499 condesin subunit E; Provisional; Region: PRK05256 1048689003500 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 1048689003501 MukB N-terminal; Region: MukB; pfam04310 1048689003502 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 1048689003503 murein L,D-transpeptidase; Provisional; Region: PRK10594 1048689003504 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1048689003505 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1048689003506 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1048689003507 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 1048689003508 Peptidase M15; Region: Peptidase_M15_3; cl01194 1048689003509 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1048689003510 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1048689003511 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1048689003512 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048689003513 homodimer interface [polypeptide binding]; other site 1048689003514 catalytic residue [active] 1048689003515 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1048689003516 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1048689003517 trimer interface [polypeptide binding]; other site 1048689003518 eyelet of channel; other site 1048689003519 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1048689003520 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 1048689003521 putative dimer interface [polypeptide binding]; other site 1048689003522 putative anticodon binding site; other site 1048689003523 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1048689003524 homodimer interface [polypeptide binding]; other site 1048689003525 motif 1; other site 1048689003526 motif 2; other site 1048689003527 active site 1048689003528 motif 3; other site 1048689003529 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 1048689003530 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 1048689003531 active site 1048689003532 aminopeptidase N; Provisional; Region: pepN; PRK14015 1048689003533 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 1048689003534 active site 1048689003535 Zn binding site [ion binding]; other site 1048689003536 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 1048689003537 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1048689003538 Walker A/P-loop; other site 1048689003539 ATP binding site [chemical binding]; other site 1048689003540 Q-loop/lid; other site 1048689003541 ABC transporter signature motif; other site 1048689003542 Walker B; other site 1048689003543 D-loop; other site 1048689003544 H-loop/switch region; other site 1048689003545 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1048689003546 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048689003547 dimer interface [polypeptide binding]; other site 1048689003548 conserved gate region; other site 1048689003549 putative PBP binding loops; other site 1048689003550 ABC-ATPase subunit interface; other site 1048689003551 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1048689003552 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1048689003553 active site 1048689003554 dimer interface [polypeptide binding]; other site 1048689003555 non-prolyl cis peptide bond; other site 1048689003556 insertion regions; other site 1048689003557 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1048689003558 substrate binding pocket [chemical binding]; other site 1048689003559 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1048689003560 membrane-bound complex binding site; other site 1048689003561 hinge residues; other site 1048689003562 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 1048689003563 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1048689003564 Fimbrial protein; Region: Fimbrial; cl01416 1048689003565 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1048689003566 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1048689003567 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1048689003568 potential frameshift: common BLAST hit: gi|238900198|ref|YP_002925994.1| putative outer membrane usher protein 1048689003569 Fimbrial protein; Region: Fimbrial; cl01416 1048689003570 Fimbrial protein; Region: Fimbrial; cl01416 1048689003571 Fimbrial protein; Region: Fimbrial; cl01416 1048689003572 putativi pili assembly chaperone; Provisional; Region: PRK11385 1048689003573 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1048689003574 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1048689003575 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1048689003576 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1048689003577 quinone interaction residues [chemical binding]; other site 1048689003578 active site 1048689003579 catalytic residues [active] 1048689003580 FMN binding site [chemical binding]; other site 1048689003581 substrate binding site [chemical binding]; other site 1048689003582 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 1048689003583 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 1048689003584 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 1048689003585 MOSC domain; Region: MOSC; pfam03473 1048689003586 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1048689003587 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1048689003588 catalytic loop [active] 1048689003589 iron binding site [ion binding]; other site 1048689003590 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 1048689003591 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1048689003592 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 1048689003593 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1048689003594 S-adenosylmethionine binding site [chemical binding]; other site 1048689003595 ABC transporter ATPase component; Reviewed; Region: PRK11147 1048689003596 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1048689003597 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1048689003598 Walker A/P-loop; other site 1048689003599 Walker A/P-loop; other site 1048689003600 ATP binding site [chemical binding]; other site 1048689003601 ATP binding site [chemical binding]; other site 1048689003602 Q-loop/lid; other site 1048689003603 Q-loop/lid; other site 1048689003604 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1048689003605 ABC transporter signature motif; other site 1048689003606 Walker B; other site 1048689003607 D-loop; other site 1048689003608 ABC transporter; Region: ABC_tran_2; pfam12848 1048689003609 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1048689003610 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 1048689003611 Paraquat-inducible protein A; Region: PqiA; pfam04403 1048689003612 Paraquat-inducible protein A; Region: PqiA; pfam04403 1048689003613 paraquat-inducible protein B; Provisional; Region: PRK10807 1048689003614 mce related protein; Region: MCE; pfam02470 1048689003615 mce related protein; Region: MCE; pfam02470 1048689003616 mce related protein; Region: MCE; pfam02470 1048689003617 DASH complex subunit Duo1; Region: DASH_Duo1; pfam08651 1048689003618 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 1048689003619 Protein of unknown function (DUF330); Region: DUF330; pfam03886 1048689003620 ribosome modulation factor; Provisional; Region: PRK14563 1048689003621 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 1048689003622 active site 1 [active] 1048689003623 dimer interface [polypeptide binding]; other site 1048689003624 active site 2 [active] 1048689003625 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 1048689003626 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1048689003627 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 1048689003628 outer membrane protein A; Reviewed; Region: PRK10808 1048689003629 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 1048689003630 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1048689003631 ligand binding site [chemical binding]; other site 1048689003632 cell division inhibitor SulA; Region: sula; TIGR00623 1048689003633 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 1048689003634 TfoX C-terminal domain; Region: TfoX_C; pfam04994 1048689003635 TIGR01666 family membrane protein; Region: YCCS 1048689003636 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1048689003637 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1048689003638 Predicted membrane protein [Function unknown]; Region: COG3304 1048689003639 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1048689003640 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1048689003641 DNA helicase IV; Provisional; Region: helD; PRK11054 1048689003642 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 1048689003643 Part of AAA domain; Region: AAA_19; pfam13245 1048689003644 Family description; Region: UvrD_C_2; pfam13538 1048689003645 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1048689003646 active site 1048689003647 dimer interfaces [polypeptide binding]; other site 1048689003648 catalytic residues [active] 1048689003649 hypothetical protein; Provisional; Region: PRK03641 1048689003650 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110 1048689003651 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1048689003652 heat shock protein HspQ; Provisional; Region: PRK14129 1048689003653 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 1048689003654 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 1048689003655 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1048689003656 putative RNA binding site [nucleotide binding]; other site 1048689003657 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1048689003658 S-adenosylmethionine binding site [chemical binding]; other site 1048689003659 Acylphosphatase; Region: Acylphosphatase; cl00551 1048689003660 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 1048689003661 sulfur transfer protein TusE; Provisional; Region: PRK11508 1048689003662 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1048689003663 YccA-like proteins; Region: YccA_like; cd10433 1048689003664 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 1048689003665 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 1048689003666 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 1048689003667 hydrogenase 1 large subunit; Provisional; Region: PRK10170 1048689003668 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 1048689003669 hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171 1048689003670 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 1048689003671 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 1048689003672 putative substrate-binding site; other site 1048689003673 nickel binding site [ion binding]; other site 1048689003674 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 1048689003675 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 1048689003676 cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035 1048689003677 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1048689003678 cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028 1048689003679 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1048689003680 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 1048689003681 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 1048689003682 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1048689003683 catalytic core [active] 1048689003684 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1048689003685 cryptic autophosphorylating protein tyrosine kinase Etk; Provisional; Region: PRK09841 1048689003686 Chain length determinant protein; Region: Wzz; pfam02706 1048689003687 Chain length determinant protein; Region: Wzz; cl15801 1048689003688 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1048689003689 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1048689003690 Nucleotide binding site [chemical binding]; other site 1048689003691 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1048689003692 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1048689003693 active site 1048689003694 polysaccharide export protein Wza; Provisional; Region: PRK15078 1048689003695 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1048689003696 SLBB domain; Region: SLBB; pfam10531 1048689003697 SLBB domain; Region: SLBB; pfam10531 1048689003698 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 1048689003699 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 1048689003700 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 1048689003701 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1048689003702 DNA-binding site [nucleotide binding]; DNA binding site 1048689003703 RNA-binding motif; other site 1048689003704 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1048689003705 DNA-binding site [nucleotide binding]; DNA binding site 1048689003706 RNA-binding motif; other site 1048689003707 cold shock gene; Provisional; Region: PRK09891 1048689003708 GnsA/GnsB family; Region: GnsAB; pfam08178 1048689003709 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 1048689003710 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1048689003711 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1048689003712 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1048689003713 hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466 1048689003714 HAMP domain; Region: HAMP; pfam00672 1048689003715 dimerization interface [polypeptide binding]; other site 1048689003716 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1048689003717 dimer interface [polypeptide binding]; other site 1048689003718 phosphorylation site [posttranslational modification] 1048689003719 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1048689003720 ATP binding site [chemical binding]; other site 1048689003721 Mg2+ binding site [ion binding]; other site 1048689003722 G-X-G motif; other site 1048689003723 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1048689003724 active site 1048689003725 phosphorylation site [posttranslational modification] 1048689003726 intermolecular recognition site; other site 1048689003727 dimerization interface [polypeptide binding]; other site 1048689003728 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1048689003729 putative binding surface; other site 1048689003730 active site 1048689003731 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 1048689003732 TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306 1048689003733 putative ligand binding site [chemical binding]; other site 1048689003734 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 1048689003735 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1048689003736 active site 1048689003737 phosphorylation site [posttranslational modification] 1048689003738 intermolecular recognition site; other site 1048689003739 dimerization interface [polypeptide binding]; other site 1048689003740 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1048689003741 DNA binding site [nucleotide binding] 1048689003742 trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032 1048689003743 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 1048689003744 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 1048689003745 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1048689003746 molybdopterin cofactor binding site [chemical binding]; other site 1048689003747 substrate binding site [chemical binding]; other site 1048689003748 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 1048689003749 molybdopterin cofactor binding site; other site 1048689003750 chaperone protein TorD; Validated; Region: torD; PRK04976 1048689003751 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 1048689003752 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 1048689003753 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 1048689003754 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1048689003755 HSP70 interaction site [polypeptide binding]; other site 1048689003756 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1048689003757 substrate binding site [polypeptide binding]; other site 1048689003758 dimer interface [polypeptide binding]; other site 1048689003759 hypothetical protein; Provisional; Region: PRK09784 1048689003760 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 1048689003761 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1048689003762 catalytic core [active] 1048689003763 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1048689003764 hypothetical protein; Provisional; Region: PRK10174 1048689003765 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 1048689003766 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1048689003767 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 1048689003768 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 1048689003769 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 1048689003770 putative FMN binding site [chemical binding]; other site 1048689003771 pyrimidine utilization protein D; Region: RutD; TIGR03611 1048689003772 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1048689003773 homotrimer interaction site [polypeptide binding]; other site 1048689003774 putative active site [active] 1048689003775 Isochorismatase family; Region: Isochorismatase; pfam00857 1048689003776 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1048689003777 catalytic triad [active] 1048689003778 conserved cis-peptide bond; other site 1048689003779 pyrimidine utilization protein A; Region: RutA; TIGR03612 1048689003780 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1048689003781 active site 1048689003782 dimer interface [polypeptide binding]; other site 1048689003783 non-prolyl cis peptide bond; other site 1048689003784 insertion regions; other site 1048689003785 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1048689003786 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 1048689003787 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1048689003788 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 1048689003789 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 1048689003790 Predicted transcriptional regulator [Transcription]; Region: COG3905 1048689003791 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 1048689003792 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 1048689003793 Glutamate binding site [chemical binding]; other site 1048689003794 NAD binding site [chemical binding]; other site 1048689003795 catalytic residues [active] 1048689003796 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1048689003797 Na binding site [ion binding]; other site 1048689003798 FTR1 family protein; Region: TIGR00145 1048689003799 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 1048689003800 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 1048689003801 Imelysin; Region: Peptidase_M75; pfam09375 1048689003802 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 1048689003803 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 1048689003804 hypothetical protein; Provisional; Region: PRK10536 1048689003805 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1048689003806 putative PGA biosynthesis protein; Provisional; Region: pgaD; PRK14585 1048689003807 N-glycosyltransferase; Provisional; Region: PRK11204 1048689003808 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1048689003809 DXD motif; other site 1048689003810 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 1048689003811 outer membrane N-deacetylase; Provisional; Region: pgaB; PRK14582 1048689003812 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 1048689003813 putative active site [active] 1048689003814 putative metal binding site [ion binding]; other site 1048689003815 outer membrane protein PgaA; Provisional; Region: pgaA; PRK10049 1048689003816 potential frameshift: common BLAST hit: gi|254792283|ref|YP_003077120.1| putative diguanylate cyclase 1048689003817 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1048689003818 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1048689003819 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 1048689003820 DNA binding site [nucleotide binding] 1048689003821 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 1048689003822 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1048689003823 NADP binding site [chemical binding]; other site 1048689003824 homodimer interface [polypeptide binding]; other site 1048689003825 active site 1048689003826 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1048689003827 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1048689003828 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1048689003829 Fimbrial protein; Region: Fimbrial; cl01416 1048689003830 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1048689003831 PapC N-terminal domain; Region: PapC_N; pfam13954 1048689003832 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1048689003833 PapC C-terminal domain; Region: PapC_C; pfam13953 1048689003834 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1048689003835 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1048689003836 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1048689003837 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1048689003838 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1048689003839 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1048689003840 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1048689003841 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 1048689003842 Phosphopantetheinyl transferase (holo-ACP synthase) [Lipid metabolism]; Region: AcpS; COG0736 1048689003843 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1048689003844 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1048689003845 NAD(P) binding site [chemical binding]; other site 1048689003846 active site 1048689003847 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1048689003848 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1048689003849 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 1048689003850 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1048689003851 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1048689003852 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1048689003853 dimer interface [polypeptide binding]; other site 1048689003854 active site 1048689003855 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1048689003856 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1048689003857 active site 1048689003858 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1048689003859 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 1048689003860 active site 1048689003861 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1048689003862 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1048689003863 Walker A/P-loop; other site 1048689003864 ATP binding site [chemical binding]; other site 1048689003865 Q-loop/lid; other site 1048689003866 ABC transporter signature motif; other site 1048689003867 Walker B; other site 1048689003868 D-loop; other site 1048689003869 H-loop/switch region; other site 1048689003870 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1048689003871 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1048689003872 FtsX-like permease family; Region: FtsX; pfam02687 1048689003873 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1048689003874 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 1048689003875 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 1048689003876 putative ligand binding site [chemical binding]; other site 1048689003877 NAD binding site [chemical binding]; other site 1048689003878 dimerization interface [polypeptide binding]; other site 1048689003879 catalytic site [active] 1048689003880 putative hydrolase; Validated; Region: PRK09248 1048689003881 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 1048689003882 active site 1048689003883 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 1048689003884 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 1048689003885 curli production assembly/transport protein CsgG; Provisional; Region: PRK15184 1048689003886 curli assembly protein CsgF; Provisional; Region: PRK10050 1048689003887 curli assembly protein CsgE; Provisional; Region: PRK10386 1048689003888 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 1048689003889 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1048689003890 DNA binding residues [nucleotide binding] 1048689003891 dimerization interface [polypeptide binding]; other site 1048689003892 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 1048689003893 Curlin associated repeat; Region: Curlin_rpt; pfam07012 1048689003894 Curlin associated repeat; Region: Curlin_rpt; pfam07012 1048689003895 major curlin subunit; Provisional; Region: csgA; PRK10051 1048689003896 Curlin associated repeat; Region: Curlin_rpt; pfam07012 1048689003897 Curlin associated repeat; Region: Curlin_rpt; pfam07012 1048689003898 curli assembly protein CsgC; Provisional; Region: csgC; PRK10102 1048689003899 Fimbrial protein; Region: Fimbrial; cl01416 1048689003900 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 1048689003901 putative ADP-ribose binding site [chemical binding]; other site 1048689003902 putative active site [active] 1048689003903 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 1048689003904 PLD-like domain; Region: PLDc_2; pfam13091 1048689003905 putative active site [active] 1048689003906 catalytic site [active] 1048689003907 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 1048689003908 PLD-like domain; Region: PLDc_2; pfam13091 1048689003909 putative active site [active] 1048689003910 catalytic site [active] 1048689003911 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 1048689003912 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1048689003913 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 1048689003914 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349 1048689003915 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1048689003916 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 1048689003917 Ligand binding site; other site 1048689003918 DXD motif; other site 1048689003919 lipoprotein; Provisional; Region: PRK10175 1048689003920 secY/secA suppressor protein; Provisional; Region: PRK11467 1048689003921 drug efflux system protein MdtG; Provisional; Region: PRK09874 1048689003922 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689003923 putative substrate translocation pore; other site 1048689003924 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1048689003925 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1048689003926 putative acyl-acceptor binding pocket; other site 1048689003927 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1048689003928 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1048689003929 active site residue [active] 1048689003930 hypothetical protein; Provisional; Region: PRK03757 1048689003931 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1048689003932 Protein of unknown function (DUF2770); Region: DUF2770; pfam10968 1048689003933 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 1048689003934 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1048689003935 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 1048689003936 DNA damage-inducible protein I; Provisional; Region: PRK10597 1048689003937 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 1048689003938 active site 1048689003939 substrate binding pocket [chemical binding]; other site 1048689003940 dimer interface [polypeptide binding]; other site 1048689003941 lipoprotein; Provisional; Region: PRK10598 1048689003942 glutaredoxin 2; Provisional; Region: PRK10387 1048689003943 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 1048689003944 C-terminal domain interface [polypeptide binding]; other site 1048689003945 GSH binding site (G-site) [chemical binding]; other site 1048689003946 catalytic residues [active] 1048689003947 putative dimer interface [polypeptide binding]; other site 1048689003948 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 1048689003949 N-terminal domain interface [polypeptide binding]; other site 1048689003950 multidrug resistance protein MdtH; Provisional; Region: PRK11646 1048689003951 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689003952 putative substrate translocation pore; other site 1048689003953 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 1048689003954 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1048689003955 hypothetical protein; Provisional; Region: PRK11239 1048689003956 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 1048689003957 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1048689003958 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1048689003959 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1048689003960 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1048689003961 MviN-like protein; Region: MVIN; pfam03023 1048689003962 flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459 1048689003963 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 1048689003964 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 1048689003965 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1048689003966 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 1048689003967 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 1048689003968 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1048689003969 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1048689003970 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1048689003971 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1048689003972 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 1048689003973 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1048689003974 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1048689003975 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 1048689003976 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1048689003977 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1048689003978 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1048689003979 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787 1048689003980 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1048689003981 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 1048689003982 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 1048689003983 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1048689003984 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1048689003985 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 1048689003986 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 1048689003987 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 1048689003988 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 1048689003989 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 1048689003990 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 1048689003991 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1048689003992 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 1048689003993 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1048689003994 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 1048689003995 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 1048689003996 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1048689003997 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1048689003998 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1048689003999 homodimer interface [polypeptide binding]; other site 1048689004000 oligonucleotide binding site [chemical binding]; other site 1048689004001 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 1048689004002 Protein of unknown function (DUF2655); Region: DUF2655; pfam10848 1048689004003 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 1048689004004 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1048689004005 RNA binding surface [nucleotide binding]; other site 1048689004006 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1048689004007 active site 1048689004008 Maf-like protein; Region: Maf; pfam02545 1048689004009 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1048689004010 active site 1048689004011 dimer interface [polypeptide binding]; other site 1048689004012 hypothetical protein; Provisional; Region: PRK11193 1048689004013 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1048689004014 putative phosphate acyltransferase; Provisional; Region: PRK05331 1048689004015 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1048689004016 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1048689004017 dimer interface [polypeptide binding]; other site 1048689004018 active site 1048689004019 CoA binding pocket [chemical binding]; other site 1048689004020 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1048689004021 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1048689004022 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1048689004023 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1048689004024 NAD(P) binding site [chemical binding]; other site 1048689004025 homotetramer interface [polypeptide binding]; other site 1048689004026 homodimer interface [polypeptide binding]; other site 1048689004027 active site 1048689004028 acyl carrier protein; Provisional; Region: acpP; PRK00982 1048689004029 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 1048689004030 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1048689004031 dimer interface [polypeptide binding]; other site 1048689004032 active site 1048689004033 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1048689004034 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1048689004035 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048689004036 catalytic residue [active] 1048689004037 conserved hypothetical protein, YceG family; Region: TIGR00247 1048689004038 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1048689004039 dimerization interface [polypeptide binding]; other site 1048689004040 thymidylate kinase; Validated; Region: tmk; PRK00698 1048689004041 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1048689004042 TMP-binding site; other site 1048689004043 ATP-binding site [chemical binding]; other site 1048689004044 DNA polymerase III subunit delta'; Validated; Region: PRK07993 1048689004045 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 1048689004046 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1048689004047 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1048689004048 active site 1048689004049 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 1048689004050 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1048689004051 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1048689004052 active site turn [active] 1048689004053 phosphorylation site [posttranslational modification] 1048689004054 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 1048689004055 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1048689004056 N-terminal plug; other site 1048689004057 ligand-binding site [chemical binding]; other site 1048689004058 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1048689004059 nucleotide binding site/active site [active] 1048689004060 HIT family signature motif; other site 1048689004061 catalytic residue [active] 1048689004062 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 1048689004063 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 1048689004064 putative dimer interface [polypeptide binding]; other site 1048689004065 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 1048689004066 thiamine kinase; Region: ycfN_thiK; TIGR02721 1048689004067 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1048689004068 active site 1048689004069 substrate binding site [chemical binding]; other site 1048689004070 ATP binding site [chemical binding]; other site 1048689004071 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1048689004072 beta-hexosaminidase; Provisional; Region: PRK05337 1048689004073 hypothetical protein; Provisional; Region: PRK04940 1048689004074 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1048689004075 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1048689004076 hypothetical protein; Provisional; Region: PRK11280 1048689004077 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1048689004078 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1048689004079 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1048689004080 L,D-transpeptidase; Provisional; Region: PRK10260 1048689004081 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1048689004082 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1048689004083 transcription-repair coupling factor; Provisional; Region: PRK10689 1048689004084 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1048689004085 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1048689004086 ATP binding site [chemical binding]; other site 1048689004087 putative Mg++ binding site [ion binding]; other site 1048689004088 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1048689004089 nucleotide binding region [chemical binding]; other site 1048689004090 ATP-binding site [chemical binding]; other site 1048689004091 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1048689004092 Predicted membrane protein [Function unknown]; Region: COG4763 1048689004093 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1048689004094 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 1048689004095 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1048689004096 FtsX-like permease family; Region: FtsX; pfam02687 1048689004097 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 1048689004098 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1048689004099 Walker A/P-loop; other site 1048689004100 ATP binding site [chemical binding]; other site 1048689004101 Q-loop/lid; other site 1048689004102 ABC transporter signature motif; other site 1048689004103 Walker B; other site 1048689004104 D-loop; other site 1048689004105 H-loop/switch region; other site 1048689004106 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 1048689004107 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1048689004108 FtsX-like permease family; Region: FtsX; pfam02687 1048689004109 fructokinase; Reviewed; Region: PRK09557 1048689004110 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1048689004111 nucleotide binding site [chemical binding]; other site 1048689004112 NAD-dependent deacetylase; Provisional; Region: PRK00481 1048689004113 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1048689004114 NAD+ binding site [chemical binding]; other site 1048689004115 substrate binding site [chemical binding]; other site 1048689004116 Zn binding site [ion binding]; other site 1048689004117 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 1048689004118 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 1048689004119 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1048689004120 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048689004121 dimer interface [polypeptide binding]; other site 1048689004122 conserved gate region; other site 1048689004123 putative PBP binding loops; other site 1048689004124 ABC-ATPase subunit interface; other site 1048689004125 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1048689004126 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048689004127 dimer interface [polypeptide binding]; other site 1048689004128 conserved gate region; other site 1048689004129 putative PBP binding loops; other site 1048689004130 ABC-ATPase subunit interface; other site 1048689004131 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 1048689004132 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1048689004133 Walker A/P-loop; other site 1048689004134 ATP binding site [chemical binding]; other site 1048689004135 Q-loop/lid; other site 1048689004136 ABC transporter signature motif; other site 1048689004137 Walker B; other site 1048689004138 D-loop; other site 1048689004139 H-loop/switch region; other site 1048689004140 TOBE domain; Region: TOBE_2; pfam08402 1048689004141 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 1048689004142 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1048689004143 metal binding site [ion binding]; metal-binding site 1048689004144 dimer interface [polypeptide binding]; other site 1048689004145 Uncharacterized conserved protein [Function unknown]; Region: COG2850 1048689004146 Cupin-like domain; Region: Cupin_8; pfam13621 1048689004147 prophage Cp5 1048689004148 integrase; Provisional; Region: PRK09692 1048689004149 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1048689004150 active site 1048689004151 Int/Topo IB signature motif; other site 1048689004152 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 1048689004153 AAA domain; Region: AAA_25; pfam13481 1048689004154 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1048689004155 Walker A motif; other site 1048689004156 ATP binding site [chemical binding]; other site 1048689004157 Walker B motif; other site 1048689004158 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1048689004159 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1048689004160 ssDNA binding site [nucleotide binding]; other site 1048689004161 dimer interface [polypeptide binding]; other site 1048689004162 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1048689004163 PerC transcriptional activator; Region: PerC; pfam06069 1048689004164 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 1048689004165 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 1048689004166 Phage DNA packaging protein Nu1; Region: Phage_Nu1; cl01720 1048689004167 sensor protein PhoQ; Provisional; Region: PRK10815 1048689004168 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 1048689004169 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1048689004170 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 1048689004171 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1048689004172 ATP binding site [chemical binding]; other site 1048689004173 Mg2+ binding site [ion binding]; other site 1048689004174 G-X-G motif; other site 1048689004175 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 1048689004176 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1048689004177 active site 1048689004178 phosphorylation site [posttranslational modification] 1048689004179 intermolecular recognition site; other site 1048689004180 dimerization interface [polypeptide binding]; other site 1048689004181 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1048689004182 DNA binding site [nucleotide binding] 1048689004183 adenylosuccinate lyase; Provisional; Region: PRK09285 1048689004184 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 1048689004185 tetramer interface [polypeptide binding]; other site 1048689004186 active site 1048689004187 putative lysogenization regulator; Reviewed; Region: PRK00218 1048689004188 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1048689004189 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 1048689004190 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 1048689004191 nudix motif; other site 1048689004192 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 1048689004193 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 1048689004194 probable active site [active] 1048689004195 isocitrate dehydrogenase; Validated; Region: PRK07362 1048689004196 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1048689004197 anti-adapter protein IraM; Provisional; Region: PRK09919 1048689004198 Protein of unknown function (DUF1398); Region: DUF1398; pfam07166 1048689004199 transcriptional regulator MirA; Provisional; Region: PRK15043 1048689004200 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 1048689004201 DNA binding residues [nucleotide binding] 1048689004202 Sensors of blue-light using FAD; Region: BLUF; smart01034 1048689004203 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1048689004204 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 1048689004205 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 1048689004206 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1048689004207 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1048689004208 potential frameshift: common BLAST hit: gi|218700252|ref|YP_002407881.1| putative outer membrane autotransporter barrel, putative pectin 1048689004209 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1048689004210 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 1048689004211 cell division inhibitor MinD; Provisional; Region: PRK10818 1048689004212 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1048689004213 Switch I; other site 1048689004214 Switch II; other site 1048689004215 septum formation inhibitor; Reviewed; Region: minC; PRK03511 1048689004216 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 1048689004217 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1048689004218 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 1048689004219 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 1048689004220 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1048689004221 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 1048689004222 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1048689004223 hypothetical protein; Provisional; Region: PRK10691 1048689004224 hypothetical protein; Provisional; Region: PRK05170 1048689004225 hemolysin E; Provisional; Region: hlyE; PRK11376 1048689004226 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1048689004227 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1048689004228 Catalytic site [active] 1048689004229 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 1048689004230 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1048689004231 active site 1048689004232 DNA binding site [nucleotide binding] 1048689004233 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1048689004234 disulfide bond formation protein B; Provisional; Region: PRK01749 1048689004235 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1048689004236 transmembrane helices; other site 1048689004237 fatty acid metabolism regulator; Provisional; Region: PRK04984 1048689004238 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1048689004239 DNA-binding site [nucleotide binding]; DNA binding site 1048689004240 FadR C-terminal domain; Region: FadR_C; pfam07840 1048689004241 SpoVR family protein; Provisional; Region: PRK11767 1048689004242 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1048689004243 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1048689004244 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1048689004245 alanine racemase; Reviewed; Region: dadX; PRK03646 1048689004246 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1048689004247 active site 1048689004248 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1048689004249 substrate binding site [chemical binding]; other site 1048689004250 catalytic residues [active] 1048689004251 dimer interface [polypeptide binding]; other site 1048689004252 Leucine rich repeat; Region: LRR_8; pfam13855 1048689004253 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 1048689004254 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1048689004255 TrkA-C domain; Region: TrkA_C; pfam02080 1048689004256 Transporter associated domain; Region: CorC_HlyC; smart01091 1048689004257 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1048689004258 dimer interface [polypeptide binding]; other site 1048689004259 catalytic triad [active] 1048689004260 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 1048689004261 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1048689004262 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1048689004263 catalytic residue [active] 1048689004264 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 1048689004265 Flagellar regulator YcgR; Region: YcgR; pfam07317 1048689004266 PilZ domain; Region: PilZ; pfam07238 1048689004267 hypothetical protein; Provisional; Region: PRK10457 1048689004268 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1048689004269 N-terminal plug; other site 1048689004270 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 1048689004271 ligand-binding site [chemical binding]; other site 1048689004272 molybdenum transport protein ModD; Provisional; Region: PRK06096 1048689004273 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 1048689004274 dimerization interface [polypeptide binding]; other site 1048689004275 active site 1048689004276 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1048689004277 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1048689004278 S-adenosylmethionine binding site [chemical binding]; other site 1048689004279 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1048689004280 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1048689004281 Walker A/P-loop; other site 1048689004282 ATP binding site [chemical binding]; other site 1048689004283 Q-loop/lid; other site 1048689004284 ABC transporter signature motif; other site 1048689004285 Walker B; other site 1048689004286 D-loop; other site 1048689004287 H-loop/switch region; other site 1048689004288 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1048689004289 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1048689004290 ABC-ATPase subunit interface; other site 1048689004291 dimer interface [polypeptide binding]; other site 1048689004292 putative PBP binding regions; other site 1048689004293 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1048689004294 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 1048689004295 putative metal binding site [ion binding]; other site 1048689004296 trehalase; Provisional; Region: treA; PRK13271 1048689004297 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 1048689004298 Trehalase; Region: Trehalase; cl17346 1048689004299 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 1048689004300 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3412 1048689004301 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1048689004302 dimerization domain swap beta strand [polypeptide binding]; other site 1048689004303 regulatory protein interface [polypeptide binding]; other site 1048689004304 active site 1048689004305 regulatory phosphorylation site [posttranslational modification]; other site 1048689004306 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1048689004307 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1048689004308 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1048689004309 dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005 1048689004310 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 1048689004311 Dak1 domain; Region: Dak1; pfam02733 1048689004312 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 1048689004313 PAS domain; Region: PAS; smart00091 1048689004314 putative active site [active] 1048689004315 heme pocket [chemical binding]; other site 1048689004316 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1048689004317 Walker A motif; other site 1048689004318 ATP binding site [chemical binding]; other site 1048689004319 Walker B motif; other site 1048689004320 arginine finger; other site 1048689004321 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1048689004322 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 1048689004323 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1048689004324 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1048689004325 GTP-binding protein YchF; Reviewed; Region: PRK09601 1048689004326 YchF GTPase; Region: YchF; cd01900 1048689004327 G1 box; other site 1048689004328 GTP/Mg2+ binding site [chemical binding]; other site 1048689004329 Switch I region; other site 1048689004330 G2 box; other site 1048689004331 Switch II region; other site 1048689004332 G3 box; other site 1048689004333 G4 box; other site 1048689004334 G5 box; other site 1048689004335 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1048689004336 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1048689004337 putative active site [active] 1048689004338 catalytic residue [active] 1048689004339 hypothetical protein; Provisional; Region: PRK10692 1048689004340 putative transporter; Provisional; Region: PRK11660 1048689004341 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1048689004342 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1048689004343 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1048689004344 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1048689004345 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1048689004346 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1048689004347 active site 1048689004348 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 1048689004349 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1048689004350 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1048689004351 outer membrane lipoprotein LolB; Region: lolB; TIGR00548 1048689004352 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 1048689004353 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1048689004354 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1048689004355 tRNA; other site 1048689004356 putative tRNA binding site [nucleotide binding]; other site 1048689004357 putative NADP binding site [chemical binding]; other site 1048689004358 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1048689004359 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1048689004360 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1048689004361 RF-1 domain; Region: RF-1; pfam00472 1048689004362 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1048689004363 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1048689004364 hypothetical protein; Provisional; Region: PRK10278 1048689004365 hypothetical protein; Provisional; Region: PRK10941 1048689004366 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 1048689004367 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 1048689004368 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1048689004369 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 1048689004370 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 1048689004371 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 1048689004372 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1048689004373 cation transport regulator; Reviewed; Region: chaB; PRK09582 1048689004374 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 1048689004375 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1048689004376 putative active site pocket [active] 1048689004377 dimerization interface [polypeptide binding]; other site 1048689004378 putative catalytic residue [active] 1048689004379 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 1048689004380 putative invasin; Provisional; Region: PRK10177 1048689004381 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 1048689004382 transcriptional regulator NarL; Provisional; Region: PRK10651 1048689004383 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1048689004384 active site 1048689004385 phosphorylation site [posttranslational modification] 1048689004386 intermolecular recognition site; other site 1048689004387 dimerization interface [polypeptide binding]; other site 1048689004388 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1048689004389 DNA binding residues [nucleotide binding] 1048689004390 dimerization interface [polypeptide binding]; other site 1048689004391 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 1048689004392 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1048689004393 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1048689004394 dimerization interface [polypeptide binding]; other site 1048689004395 Histidine kinase; Region: HisKA_3; pfam07730 1048689004396 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1048689004397 ATP binding site [chemical binding]; other site 1048689004398 Mg2+ binding site [ion binding]; other site 1048689004399 G-X-G motif; other site 1048689004400 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 1048689004401 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 1048689004402 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1048689004403 [4Fe-4S] binding site [ion binding]; other site 1048689004404 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1048689004405 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1048689004406 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1048689004407 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1048689004408 molybdopterin cofactor binding site; other site 1048689004409 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1048689004410 4Fe-4S binding domain; Region: Fer4; cl02805 1048689004411 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1048689004412 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 1048689004413 potential protein location (hypothetical protein ECO55CA74_07320 [Escherichia coli O55:H7 str. RM12579]) that overlaps RNA (tRNA-Y) 1048689004414 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1048689004415 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1048689004416 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1048689004417 putative active site [active] 1048689004418 putative substrate binding site [chemical binding]; other site 1048689004419 putative cosubstrate binding site; other site 1048689004420 catalytic site [active] 1048689004421 hypothetical protein; Provisional; Region: PRK01617 1048689004422 hypothetical protein; Provisional; Region: PRK10279 1048689004423 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 1048689004424 active site 1048689004425 nucleophile elbow; other site 1048689004426 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1048689004427 active site 1048689004428 response regulator of RpoS; Provisional; Region: PRK10693 1048689004429 phosphorylation site [posttranslational modification] 1048689004430 intermolecular recognition site; other site 1048689004431 dimerization interface [polypeptide binding]; other site 1048689004432 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1048689004433 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1048689004434 active site 1048689004435 tetramer interface; other site 1048689004436 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 1048689004437 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 1048689004438 thymidine kinase; Provisional; Region: PRK04296 1048689004439 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1048689004440 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1048689004441 putative catalytic cysteine [active] 1048689004442 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1048689004443 putative active site [active] 1048689004444 metal binding site [ion binding]; metal-binding site 1048689004445 hypothetical protein; Provisional; Region: PRK11111 1048689004446 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 1048689004447 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1048689004448 peptide binding site [polypeptide binding]; other site 1048689004449 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 1048689004450 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048689004451 dimer interface [polypeptide binding]; other site 1048689004452 conserved gate region; other site 1048689004453 putative PBP binding loops; other site 1048689004454 ABC-ATPase subunit interface; other site 1048689004455 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 1048689004456 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1048689004457 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048689004458 dimer interface [polypeptide binding]; other site 1048689004459 conserved gate region; other site 1048689004460 putative PBP binding loops; other site 1048689004461 ABC-ATPase subunit interface; other site 1048689004462 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 1048689004463 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1048689004464 Walker A/P-loop; other site 1048689004465 ATP binding site [chemical binding]; other site 1048689004466 Q-loop/lid; other site 1048689004467 ABC transporter signature motif; other site 1048689004468 Walker B; other site 1048689004469 D-loop; other site 1048689004470 H-loop/switch region; other site 1048689004471 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1048689004472 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 1048689004473 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1048689004474 Walker A/P-loop; other site 1048689004475 ATP binding site [chemical binding]; other site 1048689004476 Q-loop/lid; other site 1048689004477 ABC transporter signature motif; other site 1048689004478 Walker B; other site 1048689004479 D-loop; other site 1048689004480 H-loop/switch region; other site 1048689004481 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1048689004482 dsDNA-mimic protein; Reviewed; Region: PRK05094 1048689004483 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1048689004484 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1048689004485 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 1048689004486 putative active site [active] 1048689004487 catalytic site [active] 1048689004488 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 1048689004489 putative active site [active] 1048689004490 catalytic site [active] 1048689004491 voltage-gated potassium channel; Provisional; Region: PRK10537 1048689004492 Ion channel; Region: Ion_trans_2; pfam07885 1048689004493 TrkA-N domain; Region: TrkA_N; pfam02254 1048689004494 YciI-like protein; Reviewed; Region: PRK11370 1048689004495 transport protein TonB; Provisional; Region: PRK10819 1048689004496 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1048689004497 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1048689004498 intracellular septation protein A; Reviewed; Region: PRK00259 1048689004499 hypothetical protein; Provisional; Region: PRK02868 1048689004500 interrupted outer membrane protein W gene; sequence interrupted by a prophage 1048689004501 outer membrane protein W; Provisional; Region: PRK10959 1048689004502 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 1048689004503 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1048689004504 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1048689004505 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 1048689004506 dimer interface [polypeptide binding]; other site 1048689004507 active site 1048689004508 Int/Topo IB signature motif; other site 1048689004509 prophage Cp6 1048689004510 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1048689004511 active site 1048689004512 catalytic site [active] 1048689004513 substrate binding site [chemical binding]; other site 1048689004514 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 1048689004515 DicB protein; Region: DicB; pfam05358 1048689004516 transcriptional repressor DicA; Reviewed; Region: PRK09706 1048689004517 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1048689004518 sequence-specific DNA binding site [nucleotide binding]; other site 1048689004519 salt bridge; other site 1048689004520 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 1048689004521 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 1048689004522 Pyocin large subunit [General function prediction only]; Region: COG5529 1048689004523 Helix-turn-helix domain; Region: HTH_36; pfam13730 1048689004524 primosomal protein DnaI; Provisional; Region: PRK02854 1048689004525 Protein of unknown function (DUF1627); Region: DUF1627; pfam07789 1048689004526 Accessory colonization factor AcfC, contains ABC-type periplasmic domain [General function prediction only]; Region: AcfC; COG4588 1048689004527 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1048689004528 Hok/gef family; Region: HOK_GEF; pfam01848 1048689004529 adenylosuccinate lyase; Provisional; Region: PRK09285 1048689004530 Protein of unknown function (DUF968); Region: DUF968; pfam06147 1048689004531 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 1048689004532 Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323 1048689004533 Protein of unknown function (DUF3927); Region: DUF3927; pfam13064 1048689004534 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 1048689004535 Domain of unknown function (DUF303); Region: DUF303; pfam03629 1048689004536 Lysis protein S; Region: Lysis_S; pfam04971 1048689004537 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1048689004538 catalytic residues [active] 1048689004539 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 1048689004540 PerC transcriptional activator; Region: PerC; pfam06069 1048689004541 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1048689004542 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1048689004543 active site 1048689004544 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 1048689004545 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 1048689004546 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 1048689004547 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1048689004548 Phage capsid family; Region: Phage_capsid; pfam05065 1048689004549 Phage-related protein [Function unknown]; Region: COG4695 1048689004550 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 1048689004551 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 1048689004552 Bacteriophage head-tail adaptor [General function prediction only]; Region: COG5614 1048689004553 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 1048689004554 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 1048689004555 Immunoglobulin I-set domain; Region: I-set; pfam07679 1048689004556 Immunoglobulin domain; Region: Ig_2; pfam13895 1048689004557 Phage tail assembly chaperone; Region: Phage_TAC; pfam06222 1048689004558 Protein of unknown function (DUF4035); Region: DUF4035; pfam13227 1048689004559 Phage-related minor tail protein [Function unknown]; Region: COG5281 1048689004560 tape measure domain; Region: tape_meas_nterm; TIGR02675 1048689004561 Tail length tape measure protein; Region: Phage_HK97_TLTM; pfam06120 1048689004562 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 1048689004563 Phage-related protein [Function unknown]; Region: COG4718 1048689004564 Phage-related protein [Function unknown]; Region: gp18; COG4672 1048689004565 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 1048689004566 MPN+ (JAMM) motif; other site 1048689004567 Zinc-binding site [ion binding]; other site 1048689004568 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1048689004569 NlpC/P60 family; Region: NLPC_P60; cl17555 1048689004570 Phage-related protein, tail component [Function unknown]; Region: COG4723 1048689004571 Phage-related protein, tail component [Function unknown]; Region: COG4733 1048689004572 Putative phage tail protein; Region: Phage-tail_3; pfam13550 1048689004573 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1048689004574 Interdomain contacts; other site 1048689004575 Cytokine receptor motif; other site 1048689004576 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 1048689004577 Fibronectin type III protein; Region: DUF3672; pfam12421 1048689004578 HTH-like domain; Region: HTH_21; pfam13276 1048689004579 Integrase core domain; Region: rve; pfam00665 1048689004580 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1048689004581 Integrase core domain; Region: rve_3; pfam13683 1048689004582 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1048689004583 Transposase; Region: HTH_Tnp_1; cl17663 1048689004584 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 1048689004585 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 1048689004586 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 1048689004587 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 1048689004588 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 1048689004589 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1048689004590 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 1048689004591 dimer interface [polypeptide binding]; other site 1048689004592 active site 1048689004593 Int/Topo IB signature motif; other site 1048689004594 hypothetical protein; Provisional; Region: PHA03031 1048689004595 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1048689004596 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1048689004597 MULE transposase domain; Region: MULE; pfam10551 1048689004598 OmpW family; Region: OmpW; cl17427 1048689004599 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 1048689004600 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 1048689004601 dimerization interface [polypeptide binding]; other site 1048689004602 metal binding site [ion binding]; metal-binding site 1048689004603 General stress protein [General function prediction only]; Region: GsiB; COG3729 1048689004604 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1048689004605 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1048689004606 substrate binding site [chemical binding]; other site 1048689004607 active site 1048689004608 catalytic residues [active] 1048689004609 heterodimer interface [polypeptide binding]; other site 1048689004610 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1048689004611 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1048689004612 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048689004613 catalytic residue [active] 1048689004614 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 1048689004615 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1048689004616 active site 1048689004617 ribulose/triose binding site [chemical binding]; other site 1048689004618 phosphate binding site [ion binding]; other site 1048689004619 substrate (anthranilate) binding pocket [chemical binding]; other site 1048689004620 product (indole) binding pocket [chemical binding]; other site 1048689004621 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1048689004622 active site 1048689004623 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 1048689004624 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1048689004625 glutamine binding [chemical binding]; other site 1048689004626 catalytic triad [active] 1048689004627 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1048689004628 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1048689004629 anthranilate synthase component I; Provisional; Region: PRK13564 1048689004630 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1048689004631 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1048689004632 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1048689004633 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1048689004634 active site 1048689004635 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1048689004636 hypothetical protein; Provisional; Region: PRK11630 1048689004637 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 1048689004638 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 1048689004639 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1048689004640 RNA binding surface [nucleotide binding]; other site 1048689004641 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 1048689004642 probable active site [active] 1048689004643 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1048689004644 cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase; Validated; Region: PRK05986 1048689004645 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 1048689004646 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 1048689004647 NADP binding site [chemical binding]; other site 1048689004648 homodimer interface [polypeptide binding]; other site 1048689004649 active site 1048689004650 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 1048689004651 putative inner membrane peptidase; Provisional; Region: PRK11778 1048689004652 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1048689004653 tandem repeat interface [polypeptide binding]; other site 1048689004654 oligomer interface [polypeptide binding]; other site 1048689004655 active site residues [active] 1048689004656 hypothetical protein; Provisional; Region: PRK11037 1048689004657 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1048689004658 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1048689004659 active site 1048689004660 interdomain interaction site; other site 1048689004661 putative metal-binding site [ion binding]; other site 1048689004662 nucleotide binding site [chemical binding]; other site 1048689004663 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1048689004664 domain I; other site 1048689004665 DNA binding groove [nucleotide binding] 1048689004666 phosphate binding site [ion binding]; other site 1048689004667 domain II; other site 1048689004668 domain III; other site 1048689004669 nucleotide binding site [chemical binding]; other site 1048689004670 catalytic site [active] 1048689004671 domain IV; other site 1048689004672 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1048689004673 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1048689004674 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1048689004675 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1048689004676 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 1048689004677 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1048689004678 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 1048689004679 substrate binding site [chemical binding]; other site 1048689004680 putative dimerization interface [polypeptide binding]; other site 1048689004681 aconitate hydratase; Validated; Region: PRK09277 1048689004682 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1048689004683 substrate binding site [chemical binding]; other site 1048689004684 ligand binding site [chemical binding]; other site 1048689004685 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1048689004686 substrate binding site [chemical binding]; other site 1048689004687 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1048689004688 dimerization interface [polypeptide binding]; other site 1048689004689 active site 1048689004690 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1048689004691 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1048689004692 active site 1048689004693 Predicted membrane protein [Function unknown]; Region: COG3771 1048689004694 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 1048689004695 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1048689004696 TPR motif; other site 1048689004697 binding surface 1048689004698 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1048689004699 binding surface 1048689004700 TPR motif; other site 1048689004701 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1048689004702 active site 1048689004703 dimer interface [polypeptide binding]; other site 1048689004704 translation initiation factor Sui1; Validated; Region: PRK06824 1048689004705 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 1048689004706 putative rRNA binding site [nucleotide binding]; other site 1048689004707 lipoprotein; Provisional; Region: PRK10540 1048689004708 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1048689004709 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1048689004710 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1048689004711 hypothetical protein; Provisional; Region: PRK13658 1048689004712 RNase II stability modulator; Provisional; Region: PRK10060 1048689004713 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1048689004714 putative active site [active] 1048689004715 heme pocket [chemical binding]; other site 1048689004716 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1048689004717 metal binding site [ion binding]; metal-binding site 1048689004718 active site 1048689004719 I-site; other site 1048689004720 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1048689004721 exoribonuclease II; Provisional; Region: PRK05054 1048689004722 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1048689004723 RNB domain; Region: RNB; pfam00773 1048689004724 S1 RNA binding domain; Region: S1; pfam00575 1048689004725 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 1048689004726 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1048689004727 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 1048689004728 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1048689004729 NAD binding site [chemical binding]; other site 1048689004730 homotetramer interface [polypeptide binding]; other site 1048689004731 homodimer interface [polypeptide binding]; other site 1048689004732 substrate binding site [chemical binding]; other site 1048689004733 active site 1048689004734 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1048689004735 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1048689004736 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 1048689004737 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1048689004738 HlyD family secretion protein; Region: HlyD_3; pfam13437 1048689004739 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1048689004740 Protein export membrane protein; Region: SecD_SecF; cl14618 1048689004741 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1048689004742 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1048689004743 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1048689004744 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689004745 putative substrate translocation pore; other site 1048689004746 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 1048689004747 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1048689004748 Walker A/P-loop; other site 1048689004749 ATP binding site [chemical binding]; other site 1048689004750 Q-loop/lid; other site 1048689004751 ABC transporter signature motif; other site 1048689004752 Walker B; other site 1048689004753 D-loop; other site 1048689004754 H-loop/switch region; other site 1048689004755 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 1048689004756 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1048689004757 Walker A/P-loop; other site 1048689004758 ATP binding site [chemical binding]; other site 1048689004759 Q-loop/lid; other site 1048689004760 ABC transporter signature motif; other site 1048689004761 Walker B; other site 1048689004762 D-loop; other site 1048689004763 H-loop/switch region; other site 1048689004764 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1048689004765 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 1048689004766 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1048689004767 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048689004768 dimer interface [polypeptide binding]; other site 1048689004769 conserved gate region; other site 1048689004770 putative PBP binding loops; other site 1048689004771 ABC-ATPase subunit interface; other site 1048689004772 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 1048689004773 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048689004774 dimer interface [polypeptide binding]; other site 1048689004775 conserved gate region; other site 1048689004776 putative PBP binding loops; other site 1048689004777 ABC-ATPase subunit interface; other site 1048689004778 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1048689004779 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1048689004780 peptide binding site [polypeptide binding]; other site 1048689004781 Protein of unknown function (DUF2543); Region: DUF2543; pfam10820 1048689004782 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1048689004783 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1048689004784 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1048689004785 gamma-glutamyl-gamma-aminobutyrate hydrolase; Provisional; Region: puuD; PRK11366 1048689004786 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1048689004787 catalytic triad [active] 1048689004788 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1048689004789 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1048689004790 non-specific DNA binding site [nucleotide binding]; other site 1048689004791 salt bridge; other site 1048689004792 sequence-specific DNA binding site [nucleotide binding]; other site 1048689004793 Cupin domain; Region: Cupin_2; pfam07883 1048689004794 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 1048689004795 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 1048689004796 NAD(P) binding site [chemical binding]; other site 1048689004797 catalytic residues [active] 1048689004798 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1048689004799 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1048689004800 4-aminobutyrate transaminase; Provisional; Region: PRK09792 1048689004801 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1048689004802 inhibitor-cofactor binding pocket; inhibition site 1048689004803 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048689004804 catalytic residue [active] 1048689004805 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 1048689004806 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1048689004807 Walker A motif; other site 1048689004808 ATP binding site [chemical binding]; other site 1048689004809 Walker B motif; other site 1048689004810 arginine finger; other site 1048689004811 phage shock protein PspA; Provisional; Region: PRK10698 1048689004812 phage shock protein B; Provisional; Region: pspB; PRK09458 1048689004813 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 1048689004814 phage shock protein C; Region: phageshock_pspC; TIGR02978 1048689004815 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 1048689004816 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1048689004817 active site residue [active] 1048689004818 potential frameshift: common BLAST hit: gi|254161389|ref|YP_003044497.1| putative glucosyltransferase 1048689004819 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1048689004820 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1048689004821 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1048689004822 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048689004823 dimer interface [polypeptide binding]; other site 1048689004824 conserved gate region; other site 1048689004825 putative PBP binding loops; other site 1048689004826 ABC-ATPase subunit interface; other site 1048689004827 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1048689004828 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048689004829 dimer interface [polypeptide binding]; other site 1048689004830 conserved gate region; other site 1048689004831 putative PBP binding loops; other site 1048689004832 ABC-ATPase subunit interface; other site 1048689004833 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1048689004834 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 1048689004835 putative NAD(P) binding site [chemical binding]; other site 1048689004836 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1048689004837 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1048689004838 Metal-binding active site; metal-binding site 1048689004839 AP (apurinic/apyrimidinic) site pocket; other site 1048689004840 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1048689004841 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1048689004842 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1048689004843 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1048689004844 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1048689004845 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1048689004846 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1048689004847 beta-phosphoglucomutase; Region: bPGM; TIGR01990 1048689004848 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1048689004849 motif II; other site 1048689004850 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1048689004851 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1048689004852 Walker A/P-loop; other site 1048689004853 ATP binding site [chemical binding]; other site 1048689004854 Q-loop/lid; other site 1048689004855 ABC transporter signature motif; other site 1048689004856 Walker B; other site 1048689004857 D-loop; other site 1048689004858 H-loop/switch region; other site 1048689004859 TOBE domain; Region: TOBE_2; pfam08402 1048689004860 Outer membrane protein G (OmpG); Region: Porin_OmpG; pfam09381 1048689004861 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1048689004862 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1048689004863 DNA binding site [nucleotide binding] 1048689004864 domain linker motif; other site 1048689004865 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 1048689004866 putative dimerization interface [polypeptide binding]; other site 1048689004867 putative ligand binding site [chemical binding]; other site 1048689004868 Predicted ATPase [General function prediction only]; Region: COG3106 1048689004869 hypothetical protein; Provisional; Region: PRK05415 1048689004870 TIGR01620 family protein; Region: hyp_HI0043 1048689004871 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 1048689004872 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 1048689004873 putative aromatic amino acid binding site; other site 1048689004874 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1048689004875 Walker A motif; other site 1048689004876 ATP binding site [chemical binding]; other site 1048689004877 Walker B motif; other site 1048689004878 arginine finger; other site 1048689004879 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1048689004880 dimer interface [polypeptide binding]; other site 1048689004881 catalytic triad [active] 1048689004882 peroxidatic and resolving cysteines [active] 1048689004883 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 1048689004884 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1048689004885 active site 1048689004886 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 1048689004887 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 1048689004888 putative active site [active] 1048689004889 Zn binding site [ion binding]; other site 1048689004890 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 1048689004891 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1048689004892 putative NAD(P) binding site [chemical binding]; other site 1048689004893 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1048689004894 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1048689004895 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1048689004896 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1048689004897 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1048689004898 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1048689004899 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1048689004900 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1048689004901 putative effector binding pocket; other site 1048689004902 putative dimerization interface [polypeptide binding]; other site 1048689004903 Uncharacterized BCR, COG1636; Region: DUF208; cl17782 1048689004904 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 1048689004905 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1048689004906 peptide binding site [polypeptide binding]; other site 1048689004907 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1048689004908 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1048689004909 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 1048689004910 universal stress protein UspE; Provisional; Region: PRK11175 1048689004911 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1048689004912 Ligand Binding Site [chemical binding]; other site 1048689004913 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1048689004914 Ligand Binding Site [chemical binding]; other site 1048689004915 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 1048689004916 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1048689004917 ligand binding site [chemical binding]; other site 1048689004918 flexible hinge region; other site 1048689004919 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1048689004920 putative switch regulator; other site 1048689004921 non-specific DNA interactions [nucleotide binding]; other site 1048689004922 DNA binding site [nucleotide binding] 1048689004923 sequence specific DNA binding site [nucleotide binding]; other site 1048689004924 putative cAMP binding site [chemical binding]; other site 1048689004925 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 1048689004926 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1048689004927 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1048689004928 DNA binding site [nucleotide binding] 1048689004929 active site 1048689004930 putative aminobenzoyl-glutamate transporter; Provisional; Region: abgT; PRK11339 1048689004931 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 1048689004932 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 1048689004933 amidohydrolase; Region: amidohydrolases; TIGR01891 1048689004934 putative metal binding site [ion binding]; other site 1048689004935 M20 Peptidases Aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase from bacteria and archaea; Region: M20_Acy1_IAAspH_bact; cd05665 1048689004936 amidohydrolase; Region: amidohydrolases; TIGR01891 1048689004937 putative metal binding site [ion binding]; other site 1048689004938 dimer interface [polypeptide binding]; other site 1048689004939 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 1048689004940 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1048689004941 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 1048689004942 putative substrate binding pocket [chemical binding]; other site 1048689004943 putative dimerization interface [polypeptide binding]; other site 1048689004944 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 1048689004945 Smr domain; Region: Smr; pfam01713 1048689004946 PAS domain S-box; Region: sensory_box; TIGR00229 1048689004947 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1048689004948 putative active site [active] 1048689004949 heme pocket [chemical binding]; other site 1048689004950 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1048689004951 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1048689004952 metal binding site [ion binding]; metal-binding site 1048689004953 active site 1048689004954 I-site; other site 1048689004955 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1048689004956 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 1048689004957 Cl binding site [ion binding]; other site 1048689004958 oligomer interface [polypeptide binding]; other site 1048689004959 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 1048689004960 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1048689004961 ATP binding site [chemical binding]; other site 1048689004962 Mg++ binding site [ion binding]; other site 1048689004963 motif III; other site 1048689004964 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1048689004965 nucleotide binding region [chemical binding]; other site 1048689004966 ATP-binding site [chemical binding]; other site 1048689004967 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 1048689004968 putative RNA binding site [nucleotide binding]; other site 1048689004969 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 1048689004970 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 1048689004971 Ligand Binding Site [chemical binding]; other site 1048689004972 prophage Cp7 1048689004973 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 1048689004974 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1048689004975 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 1048689004976 Int/Topo IB signature motif; other site 1048689004977 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 1048689004978 hypothetical protein; Provisional; Region: PRK09750 1048689004979 restriction alleviation and modification protein; Reviewed; Region: lar; PRK09710 1048689004980 recombination and repair protein RecT; Reviewed; Region: recT; PRK09846 1048689004981 exonuclease VIII; Reviewed; Region: PRK09709 1048689004982 Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630 1048689004983 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 1048689004984 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 1048689004985 DicB protein; Region: DicB; pfam05358 1048689004986 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 1048689004987 transcriptional repressor DicA; Reviewed; Region: PRK09706 1048689004988 Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197 1048689004989 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 1048689004990 Helix-turn-helix domain; Region: HTH_36; pfam13730 1048689004991 primosomal protein DnaI; Provisional; Region: PRK02854 1048689004992 putative replication protein; Provisional; Region: PRK12377 1048689004993 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1048689004994 Walker A motif; other site 1048689004995 ATP binding site [chemical binding]; other site 1048689004996 Walker B motif; other site 1048689004997 arginine finger; other site 1048689004998 Protein of unknown function (DUF1627); Region: DUF1627; pfam07789 1048689004999 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 1048689005000 Domain of unknown function (DUF4406); Region: DUF4406; pfam14359 1048689005001 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 1048689005002 Hok/gef family; Region: HOK_GEF; pfam01848 1048689005003 Helix-turn-helix domain; Region: HTH_19; pfam12844 1048689005004 non-specific DNA binding site [nucleotide binding]; other site 1048689005005 salt bridge; other site 1048689005006 sequence-specific DNA binding site [nucleotide binding]; other site 1048689005007 Domain of unknown function (DUF955); Region: DUF955; cl01076 1048689005008 Protein of unknown function (DUF968); Region: DUF968; pfam06147 1048689005009 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 1048689005010 Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323 1048689005011 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 1048689005012 Domain of unknown function (DUF303); Region: DUF303; pfam03629 1048689005013 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1048689005014 Protein of unknown function (DUF1378); Region: DUF1378; pfam07125 1048689005015 Protein of unknown function (DUF826); Region: DUF826; pfam05696 1048689005016 Lysis protein S; Region: Lysis_S; pfam04971 1048689005017 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1048689005018 catalytic residues [active] 1048689005019 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 1048689005020 ORF11CD3 domain; Region: ORF11CD3; pfam10549 1048689005021 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 1048689005022 Protein of unknown function (DUF1441); Region: DUF1441; pfam07278 1048689005023 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 1048689005024 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 1048689005025 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 1048689005026 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 1048689005027 Clp protease; Region: CLP_protease; pfam00574 1048689005028 oligomer interface [polypeptide binding]; other site 1048689005029 active site residues [active] 1048689005030 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 1048689005031 Uncharacterized conserved protein [Function unknown]; Region: COG5471 1048689005032 ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; pfam13856 1048689005033 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 1048689005034 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 1048689005035 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 1048689005036 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 1048689005037 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894 1048689005038 phage tail assembly protein T; Region: phage_lam_T; TIGR01715 1048689005039 Phage-related minor tail protein [Function unknown]; Region: COG5281 1048689005040 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 1048689005041 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 1048689005042 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 1048689005043 Phage-related protein [Function unknown]; Region: COG4718 1048689005044 Phage-related protein [Function unknown]; Region: gp18; COG4672 1048689005045 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 1048689005046 MPN+ (JAMM) motif; other site 1048689005047 Zinc-binding site [ion binding]; other site 1048689005048 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1048689005049 NlpC/P60 family; Region: NLPC_P60; cl17555 1048689005050 Phage-related protein, tail component [Function unknown]; Region: COG4723 1048689005051 Phage-related protein, tail component [Function unknown]; Region: COG4733 1048689005052 Putative phage tail protein; Region: Phage-tail_3; pfam13550 1048689005053 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1048689005054 Interdomain contacts; other site 1048689005055 Cytokine receptor motif; other site 1048689005056 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 1048689005057 Fibronectin type III protein; Region: DUF3672; pfam12421 1048689005058 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 1048689005059 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 1048689005060 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 1048689005061 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 1048689005062 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 1048689005063 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 1048689005064 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 1048689005065 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 1048689005066 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1048689005067 Ligand Binding Site [chemical binding]; other site 1048689005068 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1048689005069 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1048689005070 trimer interface [polypeptide binding]; other site 1048689005071 eyelet of channel; other site 1048689005072 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 1048689005073 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1048689005074 dimer interface [polypeptide binding]; other site 1048689005075 PYR/PP interface [polypeptide binding]; other site 1048689005076 TPP binding site [chemical binding]; other site 1048689005077 substrate binding site [chemical binding]; other site 1048689005078 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1048689005079 Domain of unknown function; Region: EKR; smart00890 1048689005080 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1048689005081 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1048689005082 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 1048689005083 TPP-binding site [chemical binding]; other site 1048689005084 dimer interface [polypeptide binding]; other site 1048689005085 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 1048689005086 Domain of unknown function (DUF333); Region: DUF333; pfam03891 1048689005087 heat-inducible protein; Provisional; Region: PRK10449 1048689005088 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 1048689005089 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1048689005090 putative ligand binding site [chemical binding]; other site 1048689005091 putative NAD binding site [chemical binding]; other site 1048689005092 catalytic site [active] 1048689005093 hypothetical protein; Provisional; Region: PRK10695 1048689005094 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 1048689005095 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 1048689005096 baseplate hub subunit and tail lysozyme; Provisional; Region: 5; PHA02596 1048689005097 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1048689005098 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1048689005099 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1048689005100 active site 1048689005101 catalytic tetrad [active] 1048689005102 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1048689005103 Protein of unknown function (DUF2773); Region: DUF2773; pfam10971 1048689005104 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1048689005105 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 1048689005106 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1048689005107 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1048689005108 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1048689005109 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1048689005110 S-adenosylmethionine binding site [chemical binding]; other site 1048689005111 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 1048689005112 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1048689005113 active site 1048689005114 Dual specificity phosphatase, catalytic domain; Region: DSPc; smart00195 1048689005115 active site 1048689005116 catalytic residues [active] 1048689005117 azoreductase; Reviewed; Region: PRK00170 1048689005118 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1048689005119 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 1048689005120 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1048689005121 ATP binding site [chemical binding]; other site 1048689005122 putative Mg++ binding site [ion binding]; other site 1048689005123 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1048689005124 nucleotide binding region [chemical binding]; other site 1048689005125 ATP-binding site [chemical binding]; other site 1048689005126 Helicase associated domain (HA2); Region: HA2; pfam04408 1048689005127 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1048689005128 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1048689005129 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1048689005130 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1048689005131 putative active site [active] 1048689005132 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 1048689005133 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1048689005134 NAD binding site [chemical binding]; other site 1048689005135 catalytic residues [active] 1048689005136 substrate binding site [chemical binding]; other site 1048689005137 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1048689005138 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1048689005139 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1048689005140 cytochrome b561; Provisional; Region: PRK11513 1048689005141 hypothetical protein; Provisional; Region: PRK10040 1048689005142 small toxic polypeptide; Provisional; Region: PRK09738 1048689005143 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 1048689005144 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1048689005145 dimer interface [polypeptide binding]; other site 1048689005146 ligand binding site [chemical binding]; other site 1048689005147 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1048689005148 dimerization interface [polypeptide binding]; other site 1048689005149 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1048689005150 dimer interface [polypeptide binding]; other site 1048689005151 putative CheW interface [polypeptide binding]; other site 1048689005152 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1048689005153 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1048689005154 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1048689005155 dimerization interface [polypeptide binding]; other site 1048689005156 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 1048689005157 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 1048689005158 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 1048689005159 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 1048689005160 hypothetical protein; Provisional; Region: PRK11415 1048689005161 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1048689005162 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1048689005163 Coenzyme A binding pocket [chemical binding]; other site 1048689005164 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1048689005165 putative trimer interface [polypeptide binding]; other site 1048689005166 putative CoA binding site [chemical binding]; other site 1048689005167 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 1048689005168 putative trimer interface [polypeptide binding]; other site 1048689005169 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1048689005170 putative CoA binding site [chemical binding]; other site 1048689005171 putative trimer interface [polypeptide binding]; other site 1048689005172 putative CoA binding site [chemical binding]; other site 1048689005173 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 1048689005174 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 1048689005175 gating phenylalanine in ion channel; other site 1048689005176 tellurite resistance protein TehB; Provisional; Region: PRK11207 1048689005177 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1048689005178 S-adenosylmethionine binding site [chemical binding]; other site 1048689005179 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 1048689005180 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 1048689005181 benzoate transporter; Region: benE; TIGR00843 1048689005182 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1048689005183 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1048689005184 non-specific DNA binding site [nucleotide binding]; other site 1048689005185 salt bridge; other site 1048689005186 sequence-specific DNA binding site [nucleotide binding]; other site 1048689005187 Cupin domain; Region: Cupin_2; pfam07883 1048689005188 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1048689005189 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1048689005190 Peptidase family U32; Region: Peptidase_U32; pfam01136 1048689005191 Collagenase; Region: DUF3656; pfam12392 1048689005192 Protein of unknown function (DUF2554); Region: DUF2554; pfam10829 1048689005193 YcfA-like protein; Region: YcfA; pfam07927 1048689005194 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 1048689005195 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1048689005196 sequence-specific DNA binding site [nucleotide binding]; other site 1048689005197 salt bridge; other site 1048689005198 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1048689005199 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1048689005200 DNA-binding site [nucleotide binding]; DNA binding site 1048689005201 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1048689005202 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048689005203 homodimer interface [polypeptide binding]; other site 1048689005204 catalytic residue [active] 1048689005205 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1048689005206 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1048689005207 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1048689005208 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1048689005209 Walker A/P-loop; other site 1048689005210 ATP binding site [chemical binding]; other site 1048689005211 Q-loop/lid; other site 1048689005212 ABC transporter signature motif; other site 1048689005213 Walker B; other site 1048689005214 D-loop; other site 1048689005215 H-loop/switch region; other site 1048689005216 TOBE domain; Region: TOBE_2; pfam08402 1048689005217 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048689005218 dimer interface [polypeptide binding]; other site 1048689005219 conserved gate region; other site 1048689005220 putative PBP binding loops; other site 1048689005221 ABC-ATPase subunit interface; other site 1048689005222 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1048689005223 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048689005224 ABC-ATPase subunit interface; other site 1048689005225 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 1048689005226 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 1048689005227 tetrameric interface [polypeptide binding]; other site 1048689005228 NAD binding site [chemical binding]; other site 1048689005229 catalytic residues [active] 1048689005230 substrate binding site [chemical binding]; other site 1048689005231 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 1048689005232 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 1048689005233 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 1048689005234 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1048689005235 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1048689005236 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1048689005237 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1048689005238 NAD(P) binding site [chemical binding]; other site 1048689005239 substrate binding site [chemical binding]; other site 1048689005240 dimer interface [polypeptide binding]; other site 1048689005241 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 1048689005242 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1048689005243 DNA-binding site [nucleotide binding]; DNA binding site 1048689005244 FCD domain; Region: FCD; pfam07729 1048689005245 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1048689005246 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1048689005247 N-terminal plug; other site 1048689005248 ligand-binding site [chemical binding]; other site 1048689005249 PQQ-like domain; Region: PQQ_2; pfam13360 1048689005250 L-asparagine permease; Provisional; Region: PRK15049 1048689005251 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1048689005252 C-terminal domain interface [polypeptide binding]; other site 1048689005253 GSH binding site (G-site) [chemical binding]; other site 1048689005254 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1048689005255 dimer interface [polypeptide binding]; other site 1048689005256 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1048689005257 dimer interface [polypeptide binding]; other site 1048689005258 N-terminal domain interface [polypeptide binding]; other site 1048689005259 substrate binding pocket (H-site) [chemical binding]; other site 1048689005260 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1048689005261 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1048689005262 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1048689005263 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 1048689005264 potential frameshift: common BLAST hit: gi|15831315|ref|NP_310088.1| RhsE 1048689005265 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1048689005266 potential frameshift: common BLAST hit: gi|254793007|ref|YP_003077844.1| transposase 1048689005267 4-oxalocrotonate tautomerase; Provisional; Region: PRK01271 1048689005268 active site 1 [active] 1048689005269 dimer interface [polypeptide binding]; other site 1048689005270 hexamer interface [polypeptide binding]; other site 1048689005271 active site 2 [active] 1048689005272 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1048689005273 N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047 1048689005274 hypothetical protein; Provisional; Region: PRK10281 1048689005275 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 1048689005276 nitrate reductase 2 subunit delta; Provisional; Region: PRK15054 1048689005277 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1048689005278 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1048689005279 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1048689005280 [4Fe-4S] binding site [ion binding]; other site 1048689005281 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1048689005282 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1048689005283 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1048689005284 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1048689005285 molybdopterin cofactor binding site; other site 1048689005286 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 1048689005287 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 1048689005288 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1048689005289 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1048689005290 trimer interface [polypeptide binding]; other site 1048689005291 eyelet of channel; other site 1048689005292 aromatic amino acid exporter; Provisional; Region: PRK11689 1048689005293 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1048689005294 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1048689005295 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1048689005296 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 1048689005297 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1048689005298 molybdopterin cofactor binding site; other site 1048689005299 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 1048689005300 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 1048689005301 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 1048689005302 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 1048689005303 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 1048689005304 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1048689005305 non-specific DNA binding site [nucleotide binding]; other site 1048689005306 salt bridge; other site 1048689005307 sequence-specific DNA binding site [nucleotide binding]; other site 1048689005308 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 1048689005309 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1048689005310 NAD binding site [chemical binding]; other site 1048689005311 substrate binding site [chemical binding]; other site 1048689005312 catalytic Zn binding site [ion binding]; other site 1048689005313 tetramer interface [polypeptide binding]; other site 1048689005314 structural Zn binding site [ion binding]; other site 1048689005315 malate dehydrogenase; Provisional; Region: PRK13529 1048689005316 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1048689005317 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1048689005318 NAD(P) binding site [chemical binding]; other site 1048689005319 30S ribosomal subunit S22; Reviewed; Region: rpsV; PRK10057 1048689005320 Putative biofilm-dependent modulation protein; Region: BDM; cl11581 1048689005321 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 1048689005322 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1048689005323 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1048689005324 Walker A/P-loop; other site 1048689005325 ATP binding site [chemical binding]; other site 1048689005326 Q-loop/lid; other site 1048689005327 ABC transporter signature motif; other site 1048689005328 Walker B; other site 1048689005329 D-loop; other site 1048689005330 H-loop/switch region; other site 1048689005331 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1048689005332 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1048689005333 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1048689005334 Walker A/P-loop; other site 1048689005335 ATP binding site [chemical binding]; other site 1048689005336 Q-loop/lid; other site 1048689005337 ABC transporter signature motif; other site 1048689005338 Walker B; other site 1048689005339 D-loop; other site 1048689005340 H-loop/switch region; other site 1048689005341 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1048689005342 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 1048689005343 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1048689005344 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048689005345 dimer interface [polypeptide binding]; other site 1048689005346 conserved gate region; other site 1048689005347 putative PBP binding loops; other site 1048689005348 ABC-ATPase subunit interface; other site 1048689005349 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1048689005350 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048689005351 dimer interface [polypeptide binding]; other site 1048689005352 conserved gate region; other site 1048689005353 putative PBP binding loops; other site 1048689005354 ABC-ATPase subunit interface; other site 1048689005355 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1048689005356 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 1048689005357 D-alanyl-D-alanine dipeptidase; Provisional; Region: PRK10178 1048689005358 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 1048689005359 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1048689005360 putative active site [active] 1048689005361 heme pocket [chemical binding]; other site 1048689005362 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1048689005363 putative active site [active] 1048689005364 heme pocket [chemical binding]; other site 1048689005365 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1048689005366 metal binding site [ion binding]; metal-binding site 1048689005367 active site 1048689005368 I-site; other site 1048689005369 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1048689005370 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 1048689005371 heme-binding site [chemical binding]; other site 1048689005372 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1048689005373 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1048689005374 metal binding site [ion binding]; metal-binding site 1048689005375 active site 1048689005376 I-site; other site 1048689005377 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 1048689005378 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1048689005379 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 1048689005380 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1048689005381 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048689005382 catalytic residue [active] 1048689005383 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1048689005384 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1048689005385 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1048689005386 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1048689005387 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1048689005388 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1048689005389 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1048689005390 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 1048689005391 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 1048689005392 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 1048689005393 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 1048689005394 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1048689005395 FeS/SAM binding site; other site 1048689005396 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1048689005397 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1048689005398 Sulfatase; Region: Sulfatase; pfam00884 1048689005399 transcriptional regulator YdeO; Provisional; Region: PRK09940 1048689005400 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1048689005401 putative oxidoreductase; Provisional; Region: PRK09939 1048689005402 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1048689005403 putative molybdopterin cofactor binding site [chemical binding]; other site 1048689005404 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1048689005405 putative molybdopterin cofactor binding site; other site 1048689005406 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 1048689005407 mannosyl binding site [chemical binding]; other site 1048689005408 Fimbrial protein; Region: Fimbrial; pfam00419 1048689005409 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1048689005410 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1048689005411 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1048689005412 PapC N-terminal domain; Region: PapC_N; pfam13954 1048689005413 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1048689005414 PapC C-terminal domain; Region: PapC_C; pfam13953 1048689005415 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 1048689005416 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1048689005417 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1048689005418 Fimbrial protein; Region: Fimbrial; cl01416 1048689005419 Helix-turn-helix domain; Region: HTH_18; pfam12833 1048689005420 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1048689005421 HipA N-terminal domain; Region: Couple_hipA; pfam13657 1048689005422 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 1048689005423 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1048689005424 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1048689005425 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1048689005426 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1048689005427 non-specific DNA binding site [nucleotide binding]; other site 1048689005428 salt bridge; other site 1048689005429 sequence-specific DNA binding site [nucleotide binding]; other site 1048689005430 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1048689005431 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 1048689005432 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1048689005433 putative lipoprotein; Provisional; Region: PRK09707 1048689005434 putative lipoprotein; Provisional; Region: PRK09707 1048689005435 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 1048689005436 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 1048689005437 putative N- and C-terminal domain interface [polypeptide binding]; other site 1048689005438 putative active site [active] 1048689005439 putative MgATP binding site [chemical binding]; other site 1048689005440 catalytic site [active] 1048689005441 metal binding site [ion binding]; metal-binding site 1048689005442 putative carbohydrate binding site [chemical binding]; other site 1048689005443 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1048689005444 transcriptional regulator LsrR; Provisional; Region: PRK15418 1048689005445 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1048689005446 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1048689005447 autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439 1048689005448 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1048689005449 Walker A/P-loop; other site 1048689005450 ATP binding site [chemical binding]; other site 1048689005451 Q-loop/lid; other site 1048689005452 ABC transporter signature motif; other site 1048689005453 Walker B; other site 1048689005454 D-loop; other site 1048689005455 H-loop/switch region; other site 1048689005456 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1048689005457 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1048689005458 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1048689005459 TM-ABC transporter signature motif; other site 1048689005460 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1048689005461 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1048689005462 TM-ABC transporter signature motif; other site 1048689005463 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 1048689005464 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 1048689005465 ligand binding site [chemical binding]; other site 1048689005466 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 1048689005467 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1048689005468 putative active site; other site 1048689005469 catalytic residue [active] 1048689005470 autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486 1048689005471 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 1048689005472 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1048689005473 S-adenosylmethionine binding site [chemical binding]; other site 1048689005474 Predicted membrane protein [Function unknown]; Region: COG3781 1048689005475 altronate oxidoreductase; Provisional; Region: PRK03643 1048689005476 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1048689005477 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1048689005478 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1048689005479 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1048689005480 metal binding site [ion binding]; metal-binding site 1048689005481 active site 1048689005482 I-site; other site 1048689005483 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 1048689005484 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1048689005485 glutaminase; Provisional; Region: PRK00971 1048689005486 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 1048689005487 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1048689005488 NAD(P) binding site [chemical binding]; other site 1048689005489 catalytic residues [active] 1048689005490 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1048689005491 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1048689005492 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1048689005493 putative dimerization interface [polypeptide binding]; other site 1048689005494 potential frameshift: common BLAST hit: gi|16129486|ref|NP_416044.1| predicted protein 1048689005495 putative arabinose transporter; Provisional; Region: PRK03545 1048689005496 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689005497 putative substrate translocation pore; other site 1048689005498 inner membrane protein; Provisional; Region: PRK10995 1048689005499 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 1048689005500 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1048689005501 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 1048689005502 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1048689005503 hypothetical protein; Provisional; Region: PRK10106 1048689005504 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 1048689005505 EamA-like transporter family; Region: EamA; pfam00892 1048689005506 EamA-like transporter family; Region: EamA; pfam00892 1048689005507 putative transporter; Provisional; Region: PRK10054 1048689005508 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689005509 putative substrate translocation pore; other site 1048689005510 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 1048689005511 active site residue [active] 1048689005512 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1048689005513 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1048689005514 conserved cys residue [active] 1048689005515 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1048689005516 diguanylate cyclase; Provisional; Region: PRK09894 1048689005517 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 1048689005518 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1048689005519 metal binding site [ion binding]; metal-binding site 1048689005520 active site 1048689005521 I-site; other site 1048689005522 hypothetical protein; Provisional; Region: PRK10053 1048689005523 hypothetical protein; Validated; Region: PRK03657 1048689005524 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 1048689005525 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1048689005526 active site 1048689005527 Zn binding site [ion binding]; other site 1048689005528 malonic semialdehyde reductase; Provisional; Region: PRK10538 1048689005529 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 1048689005530 putative NAD(P) binding site [chemical binding]; other site 1048689005531 homodimer interface [polypeptide binding]; other site 1048689005532 homotetramer interface [polypeptide binding]; other site 1048689005533 active site 1048689005534 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1048689005535 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1048689005536 DNA-binding site [nucleotide binding]; DNA binding site 1048689005537 FCD domain; Region: FCD; pfam07729 1048689005538 putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318 1048689005539 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1048689005540 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1048689005541 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1048689005542 metabolite-proton symporter; Region: 2A0106; TIGR00883 1048689005543 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689005544 putative substrate translocation pore; other site 1048689005545 prophage Cp8 1048689005546 DinI-like family; Region: DinI; pfam06183 1048689005547 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1048689005548 MULE transposase domain; Region: MULE; pfam10551 1048689005549 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 1048689005550 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 1048689005551 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 1048689005552 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 1048689005553 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 1048689005554 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 1048689005555 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 1048689005556 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 1048689005557 Phage-related protein, tail component [Function unknown]; Region: COG4733 1048689005558 Putative phage tail protein; Region: Phage-tail_3; pfam13550 1048689005559 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 1048689005560 Fibronectin type III protein; Region: DUF3672; pfam12421 1048689005561 Phage-related protein, tail component [Function unknown]; Region: COG4723 1048689005562 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 1048689005563 MPN+ (JAMM) motif; other site 1048689005564 Zinc-binding site [ion binding]; other site 1048689005565 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1048689005566 NlpC/P60 family; Region: NLPC_P60; cl17555 1048689005567 Phage-related protein [Function unknown]; Region: gp18; COG4672 1048689005568 Phage-related protein [Function unknown]; Region: COG4718 1048689005569 Phage-related minor tail protein [Function unknown]; Region: COG5281 1048689005570 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 1048689005571 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 1048689005572 Minor tail protein T; Region: Phage_tail_T; cl05636 1048689005573 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894 1048689005574 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 1048689005575 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 1048689005576 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 1048689005577 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 1048689005578 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 1048689005579 DNA packaging protein FI; Region: Packaging_FI; pfam14000 1048689005580 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 1048689005581 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 1048689005582 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 1048689005583 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1048689005584 tandem repeat interface [polypeptide binding]; other site 1048689005585 oligomer interface [polypeptide binding]; other site 1048689005586 active site residues [active] 1048689005587 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 1048689005588 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 1048689005589 gpW; Region: gpW; pfam02831 1048689005590 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 1048689005591 Phage DNA packaging protein, Nu1 subunit of terminase [DNA replication, recombination, and repair]; Region: COG4220 1048689005592 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 1048689005593 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 1048689005594 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 1048689005595 ORF11CD3 domain; Region: ORF11CD3; pfam10549 1048689005596 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1048689005597 catalytic residues [active] 1048689005598 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 1048689005599 Lysis protein S; Region: Lysis_S; pfam04971 1048689005600 Protein of unknown function (DUF826); Region: DUF826; pfam05696 1048689005601 Protein of unknown function (DUF1378); Region: DUF1378; pfam07125 1048689005602 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 1048689005603 Domain of unknown function (DUF303); Region: DUF303; pfam03629 1048689005604 tellurite resistance protein terB; Region: terB; cd07176 1048689005605 putative metal binding site [ion binding]; other site 1048689005606 Antitermination protein; Region: Antiterm; pfam03589 1048689005607 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1048689005608 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 1048689005609 Protein of unknown function (DUF968); Region: DUF968; pfam06147 1048689005610 Hok/gef family; Region: HOK_GEF; pfam01848 1048689005611 Protein of unknown function (DUF551); Region: DUF551; pfam04448 1048689005612 Protein of unknown function (DUF4014); Region: DUF4014; pfam13198 1048689005613 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 1048689005614 primosomal protein DnaI; Provisional; Region: PRK02854 1048689005615 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 1048689005616 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 1048689005617 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1048689005618 non-specific DNA binding site [nucleotide binding]; other site 1048689005619 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1048689005620 salt bridge; other site 1048689005621 sequence-specific DNA binding site [nucleotide binding]; other site 1048689005622 Domain of unknown function (DUF3527); Region: DUF3527; pfam12043 1048689005623 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1048689005624 Catalytic site [active] 1048689005625 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 1048689005626 DicB protein; Region: DicB; pfam05358 1048689005627 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 1048689005628 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1048689005629 active site 1048689005630 substrate binding site [chemical binding]; other site 1048689005631 catalytic site [active] 1048689005632 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 1048689005633 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 1048689005634 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1048689005635 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 1048689005636 Int/Topo IB signature motif; other site 1048689005637 putative oxidoreductase; Provisional; Region: PRK10083 1048689005638 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 1048689005639 putative NAD(P) binding site [chemical binding]; other site 1048689005640 catalytic Zn binding site [ion binding]; other site 1048689005641 structural Zn binding site [ion binding]; other site 1048689005642 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 1048689005643 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 1048689005644 putative active site pocket [active] 1048689005645 putative metal binding site [ion binding]; other site 1048689005646 hypothetical protein; Provisional; Region: PRK02237 1048689005647 hypothetical protein; Provisional; Region: PRK13659 1048689005648 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 1048689005649 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1048689005650 Coenzyme A binding pocket [chemical binding]; other site 1048689005651 Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788 1048689005652 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 1048689005653 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 1048689005654 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1048689005655 putative [Fe4-S4] binding site [ion binding]; other site 1048689005656 putative molybdopterin cofactor binding site [chemical binding]; other site 1048689005657 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1048689005658 putative molybdopterin cofactor binding site; other site 1048689005659 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 1048689005660 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1048689005661 putative [Fe4-S4] binding site [ion binding]; other site 1048689005662 putative molybdopterin cofactor binding site [chemical binding]; other site 1048689005663 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1048689005664 putative molybdopterin cofactor binding site; other site 1048689005665 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1048689005666 4Fe-4S binding domain; Region: Fer4; cl02805 1048689005667 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 1048689005668 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 1048689005669 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1048689005670 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1048689005671 Cl- selectivity filter; other site 1048689005672 Cl- binding residues [ion binding]; other site 1048689005673 pore gating glutamate residue; other site 1048689005674 dimer interface [polypeptide binding]; other site 1048689005675 putative dithiobiotin synthetase; Provisional; Region: PRK12374 1048689005676 AAA domain; Region: AAA_26; pfam13500 1048689005677 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1048689005678 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1048689005679 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1048689005680 nucleotide binding site [chemical binding]; other site 1048689005681 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1048689005682 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1048689005683 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1048689005684 dimerization interface [polypeptide binding]; other site 1048689005685 substrate binding pocket [chemical binding]; other site 1048689005686 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1048689005687 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689005688 putative substrate translocation pore; other site 1048689005689 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1048689005690 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 1048689005691 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 1048689005692 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 1048689005693 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1048689005694 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 1048689005695 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1048689005696 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 1048689005697 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1048689005698 ligand binding site [chemical binding]; other site 1048689005699 homodimer interface [polypeptide binding]; other site 1048689005700 NAD(P) binding site [chemical binding]; other site 1048689005701 trimer interface B [polypeptide binding]; other site 1048689005702 trimer interface A [polypeptide binding]; other site 1048689005703 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1048689005704 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1048689005705 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1048689005706 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1048689005707 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 1048689005708 Spore germination protein; Region: Spore_permease; cl17796 1048689005709 dihydromonapterin reductase; Provisional; Region: PRK06483 1048689005710 pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357 1048689005711 NADP binding site [chemical binding]; other site 1048689005712 substrate binding pocket [chemical binding]; other site 1048689005713 active site 1048689005714 GlpM protein; Region: GlpM; pfam06942 1048689005715 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 1048689005716 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1048689005717 active site 1048689005718 phosphorylation site [posttranslational modification] 1048689005719 intermolecular recognition site; other site 1048689005720 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1048689005721 DNA binding site [nucleotide binding] 1048689005722 sensor protein RstB; Provisional; Region: PRK10604 1048689005723 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1048689005724 dimerization interface [polypeptide binding]; other site 1048689005725 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1048689005726 dimer interface [polypeptide binding]; other site 1048689005727 phosphorylation site [posttranslational modification] 1048689005728 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1048689005729 ATP binding site [chemical binding]; other site 1048689005730 Mg2+ binding site [ion binding]; other site 1048689005731 G-X-G motif; other site 1048689005732 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 1048689005733 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1048689005734 Class II fumarases; Region: Fumarase_classII; cd01362 1048689005735 active site 1048689005736 tetramer interface [polypeptide binding]; other site 1048689005737 fumarate hydratase; Provisional; Region: PRK15389 1048689005738 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 1048689005739 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1048689005740 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 1048689005741 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1048689005742 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1048689005743 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 1048689005744 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 1048689005745 putative outer membrane porin protein; Provisional; Region: PRK11379 1048689005746 putative outer membrane porin protein; Provisional; Region: PRK11379 1048689005747 glucuronide transporter; Provisional; Region: PRK09848 1048689005748 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1048689005749 beta-D-glucuronidase; Provisional; Region: PRK10150 1048689005750 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1048689005751 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1048689005752 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1048689005753 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1048689005754 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1048689005755 7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113 1048689005756 7 alpha-hydroxysteroid dehydrogenase (7 alpha-HSDH), classical (c) SDRs; Region: 7_alpha_HSDH_SDR_c; cd05365 1048689005757 NAD binding site [chemical binding]; other site 1048689005758 substrate binding site [chemical binding]; other site 1048689005759 homotetramer interface [polypeptide binding]; other site 1048689005760 homodimer interface [polypeptide binding]; other site 1048689005761 active site 1048689005762 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 1048689005763 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1048689005764 DNA binding site [nucleotide binding] 1048689005765 domain linker motif; other site 1048689005766 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 1048689005767 putative dimerization interface [polypeptide binding]; other site 1048689005768 putative ligand binding site [chemical binding]; other site 1048689005769 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 1048689005770 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 1048689005771 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1048689005772 active site turn [active] 1048689005773 phosphorylation site [posttranslational modification] 1048689005774 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1048689005775 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1048689005776 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048689005777 homodimer interface [polypeptide binding]; other site 1048689005778 catalytic residue [active] 1048689005779 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1048689005780 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 1048689005781 active site 1048689005782 purine riboside binding site [chemical binding]; other site 1048689005783 putative oxidoreductase; Provisional; Region: PRK11579 1048689005784 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1048689005785 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1048689005786 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 1048689005787 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 1048689005788 electron transport complex protein RsxA; Provisional; Region: PRK05151 1048689005789 electron transport complex protein RnfB; Provisional; Region: PRK05113 1048689005790 Putative Fe-S cluster; Region: FeS; pfam04060 1048689005791 4Fe-4S binding domain; Region: Fer4; pfam00037 1048689005792 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 1048689005793 SLBB domain; Region: SLBB; pfam10531 1048689005794 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1048689005795 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 1048689005796 electron transport complex protein RnfG; Validated; Region: PRK01908 1048689005797 electron transport complex RsxE subunit; Provisional; Region: PRK12405 1048689005798 endonuclease III; Provisional; Region: PRK10702 1048689005799 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1048689005800 minor groove reading motif; other site 1048689005801 helix-hairpin-helix signature motif; other site 1048689005802 substrate binding pocket [chemical binding]; other site 1048689005803 active site 1048689005804 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1048689005805 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1048689005806 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689005807 putative substrate translocation pore; other site 1048689005808 POT family; Region: PTR2; pfam00854 1048689005809 glutathionine S-transferase; Provisional; Region: PRK10542 1048689005810 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1048689005811 C-terminal domain interface [polypeptide binding]; other site 1048689005812 GSH binding site (G-site) [chemical binding]; other site 1048689005813 dimer interface [polypeptide binding]; other site 1048689005814 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1048689005815 N-terminal domain interface [polypeptide binding]; other site 1048689005816 dimer interface [polypeptide binding]; other site 1048689005817 substrate binding pocket (H-site) [chemical binding]; other site 1048689005818 pyridoxamine kinase; Validated; Region: PRK05756 1048689005819 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1048689005820 dimer interface [polypeptide binding]; other site 1048689005821 pyridoxal binding site [chemical binding]; other site 1048689005822 ATP binding site [chemical binding]; other site 1048689005823 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1048689005824 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1048689005825 active site 1048689005826 HIGH motif; other site 1048689005827 dimer interface [polypeptide binding]; other site 1048689005828 KMSKS motif; other site 1048689005829 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1048689005830 RNA binding surface [nucleotide binding]; other site 1048689005831 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 1048689005832 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1048689005833 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1048689005834 lysozyme inhibitor; Provisional; Region: PRK11372 1048689005835 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 1048689005836 Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702 1048689005837 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 1048689005838 transcriptional regulator SlyA; Provisional; Region: PRK03573 1048689005839 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1048689005840 Protein of unknown function (DUF1656); Region: DUF1656; cl11658 1048689005841 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1048689005842 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1048689005843 HlyD family secretion protein; Region: HlyD_3; pfam13437 1048689005844 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1048689005845 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1048689005846 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1048689005847 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1048689005848 E-class dimer interface [polypeptide binding]; other site 1048689005849 P-class dimer interface [polypeptide binding]; other site 1048689005850 active site 1048689005851 Cu2+ binding site [ion binding]; other site 1048689005852 Zn2+ binding site [ion binding]; other site 1048689005853 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1048689005854 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1048689005855 active site 1048689005856 catalytic tetrad [active] 1048689005857 Predicted Fe-S protein [General function prediction only]; Region: COG3313 1048689005858 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1048689005859 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1048689005860 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1048689005861 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1048689005862 FMN binding site [chemical binding]; other site 1048689005863 active site 1048689005864 substrate binding site [chemical binding]; other site 1048689005865 catalytic residue [active] 1048689005866 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1048689005867 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1048689005868 dimer interface [polypeptide binding]; other site 1048689005869 active site 1048689005870 metal binding site [ion binding]; metal-binding site 1048689005871 glutathione binding site [chemical binding]; other site 1048689005872 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1048689005873 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 1048689005874 dimer interface [polypeptide binding]; other site 1048689005875 catalytic site [active] 1048689005876 putative active site [active] 1048689005877 putative substrate binding site [chemical binding]; other site 1048689005878 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1048689005879 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 1048689005880 ATP binding site [chemical binding]; other site 1048689005881 putative Mg++ binding site [ion binding]; other site 1048689005882 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1048689005883 nucleotide binding region [chemical binding]; other site 1048689005884 ATP-binding site [chemical binding]; other site 1048689005885 DEAD/H associated; Region: DEAD_assoc; pfam08494 1048689005886 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1048689005887 putative GSH binding site [chemical binding]; other site 1048689005888 catalytic residues [active] 1048689005889 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1048689005890 NlpC/P60 family; Region: NLPC_P60; pfam00877 1048689005891 superoxide dismutase; Provisional; Region: PRK10543 1048689005892 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1048689005893 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1048689005894 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689005895 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1048689005896 putative substrate translocation pore; other site 1048689005897 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 1048689005898 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1048689005899 DNA binding site [nucleotide binding] 1048689005900 domain linker motif; other site 1048689005901 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 1048689005902 dimerization interface [polypeptide binding]; other site 1048689005903 ligand binding site [chemical binding]; other site 1048689005904 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1048689005905 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1048689005906 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1048689005907 dimerization interface [polypeptide binding]; other site 1048689005908 putative transporter; Provisional; Region: PRK11043 1048689005909 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689005910 putative substrate translocation pore; other site 1048689005911 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 1048689005912 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1048689005913 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1048689005914 S-adenosylmethionine binding site [chemical binding]; other site 1048689005915 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 1048689005916 Lumazine binding domain; Region: Lum_binding; pfam00677 1048689005917 Lumazine binding domain; Region: Lum_binding; pfam00677 1048689005918 multidrug efflux protein; Reviewed; Region: PRK01766 1048689005919 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1048689005920 cation binding site [ion binding]; other site 1048689005921 hypothetical protein; Provisional; Region: PRK09945 1048689005922 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 1048689005923 putative monooxygenase; Provisional; Region: PRK11118 1048689005924 hypothetical protein; Provisional; Region: PRK09897 1048689005925 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1048689005926 hypothetical protein; Provisional; Region: PRK09946 1048689005927 thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006 1048689005928 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 1048689005929 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 1048689005930 hypothetical protein; Provisional; Region: PRK09947 1048689005931 putative oxidoreductase; Provisional; Region: PRK09849 1048689005932 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 1048689005933 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 1048689005934 hypothetical protein; Provisional; Region: PRK09898 1048689005935 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1048689005936 hypothetical protein; Provisional; Region: PRK10292 1048689005937 pyruvate kinase; Provisional; Region: PRK09206 1048689005938 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 1048689005939 domain interfaces; other site 1048689005940 active site 1048689005941 murein lipoprotein; Provisional; Region: PRK15396 1048689005942 L,D-transpeptidase; Provisional; Region: PRK10190 1048689005943 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1048689005944 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1048689005945 cysteine desufuration protein SufE; Provisional; Region: PRK09296 1048689005946 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1048689005947 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1048689005948 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1048689005949 catalytic residue [active] 1048689005950 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 1048689005951 FeS assembly protein SufD; Region: sufD; TIGR01981 1048689005952 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 1048689005953 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1048689005954 Walker A/P-loop; other site 1048689005955 ATP binding site [chemical binding]; other site 1048689005956 Q-loop/lid; other site 1048689005957 ABC transporter signature motif; other site 1048689005958 Walker B; other site 1048689005959 D-loop; other site 1048689005960 H-loop/switch region; other site 1048689005961 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 1048689005962 putative ABC transporter; Region: ycf24; CHL00085 1048689005963 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 1048689005964 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1048689005965 CoenzymeA binding site [chemical binding]; other site 1048689005966 subunit interaction site [polypeptide binding]; other site 1048689005967 PHB binding site; other site 1048689005968 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1048689005969 FAD binding domain; Region: FAD_binding_4; pfam01565 1048689005970 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1048689005971 putative inner membrane protein; Provisional; Region: PRK10983 1048689005972 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1048689005973 Domain of unknown function (DUF1870); Region: DUF1870; pfam08965 1048689005974 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689005975 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1048689005976 putative substrate translocation pore; other site 1048689005977 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689005978 putative substrate translocation pore; other site 1048689005979 quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749 1048689005980 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1048689005981 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1048689005982 shikimate binding site; other site 1048689005983 NAD(P) binding site [chemical binding]; other site 1048689005984 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 1048689005985 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1048689005986 active site 1048689005987 catalytic residue [active] 1048689005988 dimer interface [polypeptide binding]; other site 1048689005989 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 1048689005990 Coenzyme A transferase; Region: CoA_trans; smart00882 1048689005991 Coenzyme A transferase; Region: CoA_trans; cl17247 1048689005992 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 1048689005993 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1048689005994 active site 1048689005995 Cupin domain; Region: Cupin_2; pfam07883 1048689005996 Winged helix DNA-binding domain (DUF1495); Region: DUF1495; cl01336 1048689005997 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1048689005998 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1048689005999 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1048689006000 Ligand binding site [chemical binding]; other site 1048689006001 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1048689006002 electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916 1048689006003 Electron transfer flavoprotein domain; Region: ETF; smart00893 1048689006004 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1048689006005 oxidoreductase; Provisional; Region: PRK10015 1048689006006 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 1048689006007 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 1048689006008 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 1048689006009 acyl-activating enzyme (AAE) consensus motif; other site 1048689006010 putative AMP binding site [chemical binding]; other site 1048689006011 putative active site [active] 1048689006012 putative CoA binding site [chemical binding]; other site 1048689006013 phosphoenolpyruvate synthase; Validated; Region: PRK06464 1048689006014 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1048689006015 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1048689006016 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1048689006017 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1048689006018 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 1048689006019 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1048689006020 Hemin uptake protein [Inorganic ion transport and metabolism]; Region: HemP; COG4256 1048689006021 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1048689006022 hypothetical protein; Validated; Region: PRK00029 1048689006023 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 1048689006024 NlpC/P60 family; Region: NLPC_P60; pfam00877 1048689006025 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 1048689006026 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1048689006027 Walker A/P-loop; other site 1048689006028 ATP binding site [chemical binding]; other site 1048689006029 Q-loop/lid; other site 1048689006030 ABC transporter signature motif; other site 1048689006031 Walker B; other site 1048689006032 D-loop; other site 1048689006033 H-loop/switch region; other site 1048689006034 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1048689006035 catalytic residues [active] 1048689006036 dimer interface [polypeptide binding]; other site 1048689006037 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1048689006038 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1048689006039 ABC-ATPase subunit interface; other site 1048689006040 dimer interface [polypeptide binding]; other site 1048689006041 putative PBP binding regions; other site 1048689006042 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1048689006043 IHF dimer interface [polypeptide binding]; other site 1048689006044 IHF - DNA interface [nucleotide binding]; other site 1048689006045 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1048689006046 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1048689006047 putative tRNA-binding site [nucleotide binding]; other site 1048689006048 B3/4 domain; Region: B3_4; pfam03483 1048689006049 tRNA synthetase B5 domain; Region: B5; smart00874 1048689006050 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1048689006051 dimer interface [polypeptide binding]; other site 1048689006052 motif 1; other site 1048689006053 motif 3; other site 1048689006054 motif 2; other site 1048689006055 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1048689006056 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1048689006057 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1048689006058 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1048689006059 dimer interface [polypeptide binding]; other site 1048689006060 motif 1; other site 1048689006061 active site 1048689006062 motif 2; other site 1048689006063 motif 3; other site 1048689006064 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1048689006065 23S rRNA binding site [nucleotide binding]; other site 1048689006066 L21 binding site [polypeptide binding]; other site 1048689006067 L13 binding site [polypeptide binding]; other site 1048689006068 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1048689006069 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1048689006070 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1048689006071 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1048689006072 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1048689006073 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1048689006074 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1048689006075 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1048689006076 active site 1048689006077 dimer interface [polypeptide binding]; other site 1048689006078 motif 1; other site 1048689006079 motif 2; other site 1048689006080 motif 3; other site 1048689006081 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1048689006082 anticodon binding site; other site 1048689006083 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 1048689006084 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 1048689006085 6-phosphofructokinase 2; Provisional; Region: PRK10294 1048689006086 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1048689006087 putative substrate binding site [chemical binding]; other site 1048689006088 putative ATP binding site [chemical binding]; other site 1048689006089 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 1048689006090 Phosphotransferase enzyme family; Region: APH; pfam01636 1048689006091 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1048689006092 active site 1048689006093 ATP binding site [chemical binding]; other site 1048689006094 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1048689006095 YniB-like protein; Region: YniB; pfam14002 1048689006096 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 1048689006097 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1048689006098 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1048689006099 motif II; other site 1048689006100 inner membrane protein; Provisional; Region: PRK11648 1048689006101 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1048689006102 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1048689006103 cell division modulator; Provisional; Region: PRK10113 1048689006104 hydroperoxidase II; Provisional; Region: katE; PRK11249 1048689006105 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 1048689006106 tetramer interface [polypeptide binding]; other site 1048689006107 heme binding pocket [chemical binding]; other site 1048689006108 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1048689006109 domain interactions; other site 1048689006110 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 1048689006111 putative active site [active] 1048689006112 YdjC motif; other site 1048689006113 Mg binding site [ion binding]; other site 1048689006114 putative homodimer interface [polypeptide binding]; other site 1048689006115 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1048689006116 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1048689006117 NAD binding site [chemical binding]; other site 1048689006118 sugar binding site [chemical binding]; other site 1048689006119 divalent metal binding site [ion binding]; other site 1048689006120 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1048689006121 dimer interface [polypeptide binding]; other site 1048689006122 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 1048689006123 Cupin domain; Region: Cupin_2; pfam07883 1048689006124 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1048689006125 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1048689006126 methionine cluster; other site 1048689006127 active site 1048689006128 phosphorylation site [posttranslational modification] 1048689006129 metal binding site [ion binding]; metal-binding site 1048689006130 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 1048689006131 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1048689006132 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1048689006133 active site 1048689006134 P-loop; other site 1048689006135 phosphorylation site [posttranslational modification] 1048689006136 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 1048689006137 NAD+ synthetase; Region: nadE; TIGR00552 1048689006138 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1048689006139 homodimer interface [polypeptide binding]; other site 1048689006140 NAD binding pocket [chemical binding]; other site 1048689006141 ATP binding pocket [chemical binding]; other site 1048689006142 Mg binding site [ion binding]; other site 1048689006143 active-site loop [active] 1048689006144 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 1048689006145 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1048689006146 GIY-YIG motif/motif A; other site 1048689006147 active site 1048689006148 catalytic site [active] 1048689006149 putative DNA binding site [nucleotide binding]; other site 1048689006150 metal binding site [ion binding]; metal-binding site 1048689006151 hypothetical protein; Provisional; Region: PRK11396 1048689006152 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1048689006153 dimer interface [polypeptide binding]; other site 1048689006154 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 1048689006155 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 1048689006156 putative active site [active] 1048689006157 Zn binding site [ion binding]; other site 1048689006158 succinylarginine dihydrolase; Provisional; Region: PRK13281 1048689006159 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 1048689006160 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 1048689006161 NAD(P) binding site [chemical binding]; other site 1048689006162 catalytic residues [active] 1048689006163 arginine succinyltransferase; Provisional; Region: PRK10456 1048689006164 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 1048689006165 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 1048689006166 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1048689006167 inhibitor-cofactor binding pocket; inhibition site 1048689006168 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048689006169 catalytic residue [active] 1048689006170 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1048689006171 putative catalytic site [active] 1048689006172 putative phosphate binding site [ion binding]; other site 1048689006173 active site 1048689006174 metal binding site A [ion binding]; metal-binding site 1048689006175 DNA binding site [nucleotide binding] 1048689006176 putative AP binding site [nucleotide binding]; other site 1048689006177 putative metal binding site B [ion binding]; other site 1048689006178 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1048689006179 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1048689006180 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1048689006181 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1048689006182 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1048689006183 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1048689006184 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 1048689006185 hypothetical protein; Provisional; Region: PRK11622 1048689006186 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135 1048689006187 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048689006188 dimer interface [polypeptide binding]; other site 1048689006189 conserved gate region; other site 1048689006190 putative PBP binding loops; other site 1048689006191 ABC-ATPase subunit interface; other site 1048689006192 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 1048689006193 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1048689006194 Walker A/P-loop; other site 1048689006195 ATP binding site [chemical binding]; other site 1048689006196 Q-loop/lid; other site 1048689006197 ABC transporter signature motif; other site 1048689006198 Walker B; other site 1048689006199 D-loop; other site 1048689006200 H-loop/switch region; other site 1048689006201 Rhodanese Homology Domain; Region: RHOD; smart00450 1048689006202 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1048689006203 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1048689006204 active site residue [active] 1048689006205 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1048689006206 active site residue [active] 1048689006207 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1048689006208 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1048689006209 active site 1048689006210 8-oxo-dGMP binding site [chemical binding]; other site 1048689006211 nudix motif; other site 1048689006212 metal binding site [ion binding]; metal-binding site 1048689006213 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 1048689006214 glutamate dehydrogenase; Provisional; Region: PRK09414 1048689006215 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1048689006216 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1048689006217 NAD(P) binding site [chemical binding]; other site 1048689006218 hypothetical protein; Provisional; Region: PRK11380 1048689006219 DNA topoisomerase III; Provisional; Region: PRK07726 1048689006220 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1048689006221 active site 1048689006222 putative interdomain interaction site [polypeptide binding]; other site 1048689006223 putative metal-binding site [ion binding]; other site 1048689006224 putative nucleotide binding site [chemical binding]; other site 1048689006225 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1048689006226 domain I; other site 1048689006227 DNA binding groove [nucleotide binding] 1048689006228 phosphate binding site [ion binding]; other site 1048689006229 domain II; other site 1048689006230 domain III; other site 1048689006231 nucleotide binding site [chemical binding]; other site 1048689006232 catalytic site [active] 1048689006233 domain IV; other site 1048689006234 selenophosphate synthetase; Provisional; Region: PRK00943 1048689006235 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 1048689006236 dimerization interface [polypeptide binding]; other site 1048689006237 putative ATP binding site [chemical binding]; other site 1048689006238 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1048689006239 putative FMN binding site [chemical binding]; other site 1048689006240 protease 4; Provisional; Region: PRK10949 1048689006241 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 1048689006242 tandem repeat interface [polypeptide binding]; other site 1048689006243 oligomer interface [polypeptide binding]; other site 1048689006244 active site residues [active] 1048689006245 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 1048689006246 tandem repeat interface [polypeptide binding]; other site 1048689006247 oligomer interface [polypeptide binding]; other site 1048689006248 active site residues [active] 1048689006249 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859 1048689006250 Uncharacterized conserved protein [Function unknown]; Region: COG2968 1048689006251 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1048689006252 active site 1048689006253 homodimer interface [polypeptide binding]; other site 1048689006254 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1048689006255 Isochorismatase family; Region: Isochorismatase; pfam00857 1048689006256 catalytic triad [active] 1048689006257 metal binding site [ion binding]; metal-binding site 1048689006258 conserved cis-peptide bond; other site 1048689006259 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1048689006260 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689006261 putative substrate translocation pore; other site 1048689006262 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689006263 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1048689006264 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1048689006265 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1048689006266 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1048689006267 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1048689006268 active site 1048689006269 catalytic tetrad [active] 1048689006270 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1048689006271 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1048689006272 substrate binding site [chemical binding]; other site 1048689006273 ATP binding site [chemical binding]; other site 1048689006274 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1048689006275 intersubunit interface [polypeptide binding]; other site 1048689006276 active site 1048689006277 zinc binding site [ion binding]; other site 1048689006278 Na+ binding site [ion binding]; other site 1048689006279 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1048689006280 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 1048689006281 inhibitor binding site; inhibition site 1048689006282 catalytic Zn binding site [ion binding]; other site 1048689006283 structural Zn binding site [ion binding]; other site 1048689006284 NADP binding site [chemical binding]; other site 1048689006285 tetramer interface [polypeptide binding]; other site 1048689006286 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1048689006287 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 1048689006288 putative NAD(P) binding site [chemical binding]; other site 1048689006289 catalytic Zn binding site [ion binding]; other site 1048689006290 structural Zn binding site [ion binding]; other site 1048689006291 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 1048689006292 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1048689006293 SelR domain; Region: SelR; pfam01641 1048689006294 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 1048689006295 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1048689006296 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1048689006297 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 1048689006298 active site 1048689006299 phosphate binding residues; other site 1048689006300 catalytic residues [active] 1048689006301 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1048689006302 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1048689006303 active site 1048689006304 catalytic tetrad [active] 1048689006305 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 1048689006306 PrkA family serine protein kinase; Provisional; Region: PRK15455 1048689006307 AAA ATPase domain; Region: AAA_16; pfam13191 1048689006308 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1048689006309 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1048689006310 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1048689006311 metal binding site [ion binding]; metal-binding site 1048689006312 active site 1048689006313 I-site; other site 1048689006314 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1048689006315 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1048689006316 metal binding site [ion binding]; metal-binding site 1048689006317 active site 1048689006318 I-site; other site 1048689006319 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 1048689006320 putative deacylase active site [active] 1048689006321 Predicted membrane protein [Function unknown]; Region: COG2707 1048689006322 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1048689006323 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1048689006324 cyanate transporter; Region: CynX; TIGR00896 1048689006325 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689006326 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1048689006327 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 1048689006328 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1048689006329 Domain of unknown function (DUF333); Region: DUF333; pfam03891 1048689006330 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1048689006331 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1048689006332 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1048689006333 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1048689006334 metal binding site [ion binding]; metal-binding site 1048689006335 active site 1048689006336 I-site; other site 1048689006337 hypothetical protein; Provisional; Region: PRK10457 1048689006338 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 1048689006339 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 1048689006340 leucine export protein LeuE; Provisional; Region: PRK10958 1048689006341 transcriptional activator TtdR; Provisional; Region: PRK09801 1048689006342 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1048689006343 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 1048689006344 putative effector binding pocket; other site 1048689006345 putative dimerization interface [polypeptide binding]; other site 1048689006346 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1048689006347 tartrate dehydrogenase; Region: TTC; TIGR02089 1048689006348 putative transporter; Provisional; Region: PRK09950 1048689006349 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1048689006350 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1048689006351 [2Fe-2S] cluster binding site [ion binding]; other site 1048689006352 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_2; cd08886 1048689006353 putative alpha subunit interface [polypeptide binding]; other site 1048689006354 putative active site [active] 1048689006355 putative substrate binding site [chemical binding]; other site 1048689006356 Fe binding site [ion binding]; other site 1048689006357 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1048689006358 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1048689006359 FMN-binding pocket [chemical binding]; other site 1048689006360 flavin binding motif; other site 1048689006361 phosphate binding motif [ion binding]; other site 1048689006362 beta-alpha-beta structure motif; other site 1048689006363 NAD binding pocket [chemical binding]; other site 1048689006364 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1048689006365 catalytic loop [active] 1048689006366 iron binding site [ion binding]; other site 1048689006367 ribonuclease D; Provisional; Region: PRK10829 1048689006368 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1048689006369 catalytic site [active] 1048689006370 putative active site [active] 1048689006371 putative substrate binding site [chemical binding]; other site 1048689006372 Helicase and RNase D C-terminal; Region: HRDC; smart00341 1048689006373 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 1048689006374 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1048689006375 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1048689006376 acyl-activating enzyme (AAE) consensus motif; other site 1048689006377 putative AMP binding site [chemical binding]; other site 1048689006378 putative active site [active] 1048689006379 putative CoA binding site [chemical binding]; other site 1048689006380 Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065 1048689006381 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 1048689006382 Glycoprotease family; Region: Peptidase_M22; pfam00814 1048689006383 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1048689006384 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1048689006385 DEAD_2; Region: DEAD_2; pfam06733 1048689006386 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1048689006387 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 1048689006388 homotrimer interaction site [polypeptide binding]; other site 1048689006389 putative active site [active] 1048689006390 Domain of unknown function (DUF1889); Region: DUF1889; pfam08986 1048689006391 hypothetical protein; Provisional; Region: PRK05114 1048689006392 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 1048689006393 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1048689006394 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 1048689006395 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1048689006396 putative active site [active] 1048689006397 putative CoA binding site [chemical binding]; other site 1048689006398 nudix motif; other site 1048689006399 metal binding site [ion binding]; metal-binding site 1048689006400 L-serine deaminase; Provisional; Region: PRK15023 1048689006401 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1048689006402 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1048689006403 phage resistance protein; Provisional; Region: PRK10551 1048689006404 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1048689006405 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1048689006406 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1048689006407 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1048689006408 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1048689006409 Transporter associated domain; Region: CorC_HlyC; smart01091 1048689006410 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 1048689006411 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1048689006412 active pocket/dimerization site; other site 1048689006413 active site 1048689006414 phosphorylation site [posttranslational modification] 1048689006415 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1048689006416 active site 1048689006417 phosphorylation site [posttranslational modification] 1048689006418 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 1048689006419 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 1048689006420 Predicted membrane protein [Function unknown]; Region: COG4811 1048689006421 hypothetical protein; Provisional; Region: PRK11469 1048689006422 Domain of unknown function DUF; Region: DUF204; pfam02659 1048689006423 Domain of unknown function DUF; Region: DUF204; pfam02659 1048689006424 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1048689006425 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1048689006426 S-adenosylmethionine binding site [chemical binding]; other site 1048689006427 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1048689006428 DNA-binding site [nucleotide binding]; DNA binding site 1048689006429 RNA-binding motif; other site 1048689006430 Protein of unknown function (DUF2627); Region: DUF2527; pfam10736 1048689006431 YebO-like protein; Region: YebO; pfam13974 1048689006432 PhoPQ regulatory protein; Provisional; Region: PRK10299 1048689006433 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 1048689006434 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1048689006435 dimerization interface [polypeptide binding]; other site 1048689006436 putative Zn2+ binding site [ion binding]; other site 1048689006437 putative DNA binding site [nucleotide binding]; other site 1048689006438 Bacterial transcriptional regulator; Region: IclR; pfam01614 1048689006439 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689006440 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1048689006441 putative substrate translocation pore; other site 1048689006442 Predicted integral membrane protein [Function unknown]; Region: COG5521 1048689006443 heat shock protein HtpX; Provisional; Region: PRK05457 1048689006444 carboxy-terminal protease; Provisional; Region: PRK11186 1048689006445 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1048689006446 protein binding site [polypeptide binding]; other site 1048689006447 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1048689006448 Catalytic dyad [active] 1048689006449 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 1048689006450 ProP expression regulator; Provisional; Region: PRK04950 1048689006451 ProQ/FINO family; Region: ProQ; pfam04352 1048689006452 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1048689006453 GAF domain; Region: GAF_2; pfam13185 1048689006454 integral membrane protein, PqiA family; Region: pqiA_fam; TIGR00155 1048689006455 Paraquat-inducible protein A; Region: PqiA; pfam04403 1048689006456 Paraquat-inducible protein A; Region: PqiA; pfam04403 1048689006457 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 1048689006458 mce related protein; Region: MCE; pfam02470 1048689006459 mce related protein; Region: MCE; pfam02470 1048689006460 mce related protein; Region: MCE; pfam02470 1048689006461 mce related protein; Region: MCE; pfam02470 1048689006462 mce related protein; Region: MCE; pfam02470 1048689006463 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 1048689006464 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1048689006465 S-adenosylmethionine binding site [chemical binding]; other site 1048689006466 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 1048689006467 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 1048689006468 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 1048689006469 serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439 1048689006470 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1048689006471 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 1048689006472 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 1048689006473 hypothetical protein; Provisional; Region: PRK10301 1048689006474 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 1048689006475 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1048689006476 Carbon-nitrogen hydrolase; Region: CN_hydrolase; pfam00795 1048689006477 exodeoxyribonuclease X; Provisional; Region: PRK07983 1048689006478 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1048689006479 active site 1048689006480 catalytic site [active] 1048689006481 substrate binding site [chemical binding]; other site 1048689006482 protease 2; Provisional; Region: PRK10115 1048689006483 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1048689006484 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 1048689006485 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 1048689006486 putative metal binding site [ion binding]; other site 1048689006487 hypothetical protein; Provisional; Region: PRK13680 1048689006488 DNA damage-inducible protein YebG; Provisional; Region: PRK10061 1048689006489 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1048689006490 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1048689006491 ATP-grasp domain; Region: ATP-grasp; pfam02222 1048689006492 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 1048689006493 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1048689006494 active site 1048689006495 intersubunit interface [polypeptide binding]; other site 1048689006496 catalytic residue [active] 1048689006497 phosphogluconate dehydratase; Validated; Region: PRK09054 1048689006498 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1048689006499 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1048689006500 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1048689006501 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1048689006502 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 1048689006503 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1048689006504 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1048689006505 putative active site [active] 1048689006506 pyruvate kinase; Provisional; Region: PRK05826 1048689006507 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 1048689006508 domain interfaces; other site 1048689006509 active site 1048689006510 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1048689006511 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1048689006512 putative acyl-acceptor binding pocket; other site 1048689006513 putative peptidase; Provisional; Region: PRK11649 1048689006514 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 1048689006515 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1048689006516 Peptidase family M23; Region: Peptidase_M23; pfam01551 1048689006517 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 1048689006518 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 1048689006519 metal binding site [ion binding]; metal-binding site 1048689006520 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 1048689006521 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1048689006522 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1048689006523 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1048689006524 ABC-ATPase subunit interface; other site 1048689006525 dimer interface [polypeptide binding]; other site 1048689006526 putative PBP binding regions; other site 1048689006527 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1048689006528 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1048689006529 Walker A motif; other site 1048689006530 ATP binding site [chemical binding]; other site 1048689006531 Walker B motif; other site 1048689006532 arginine finger; other site 1048689006533 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1048689006534 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1048689006535 RuvA N terminal domain; Region: RuvA_N; pfam01330 1048689006536 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1048689006537 hypothetical protein; Provisional; Region: PRK11470 1048689006538 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1048689006539 active site 1048689006540 putative DNA-binding cleft [nucleotide binding]; other site 1048689006541 dimer interface [polypeptide binding]; other site 1048689006542 hypothetical protein; Validated; Region: PRK00110 1048689006543 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 1048689006544 nudix motif; other site 1048689006545 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1048689006546 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1048689006547 dimer interface [polypeptide binding]; other site 1048689006548 anticodon binding site; other site 1048689006549 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1048689006550 homodimer interface [polypeptide binding]; other site 1048689006551 motif 1; other site 1048689006552 active site 1048689006553 motif 2; other site 1048689006554 GAD domain; Region: GAD; pfam02938 1048689006555 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1048689006556 motif 3; other site 1048689006557 Isochorismatase family; Region: Isochorismatase; pfam00857 1048689006558 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1048689006559 catalytic triad [active] 1048689006560 conserved cis-peptide bond; other site 1048689006561 hypothetical protein; Provisional; Region: PRK10302 1048689006562 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 1048689006563 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1048689006564 S-adenosylmethionine binding site [chemical binding]; other site 1048689006565 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1048689006566 S-adenosylmethionine binding site [chemical binding]; other site 1048689006567 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 1048689006568 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1048689006569 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 1048689006570 molybdopterin cofactor binding site [chemical binding]; other site 1048689006571 substrate binding site [chemical binding]; other site 1048689006572 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 1048689006573 molybdopterin cofactor binding site; other site 1048689006574 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 1048689006575 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 1048689006576 copper homeostasis protein CutC; Provisional; Region: PRK11572 1048689006577 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 1048689006578 putative metal binding site [ion binding]; other site 1048689006579 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1048689006580 arginyl-tRNA synthetase; Region: argS; TIGR00456 1048689006581 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1048689006582 active site 1048689006583 HIGH motif; other site 1048689006584 KMSK motif region; other site 1048689006585 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1048689006586 tRNA binding surface [nucleotide binding]; other site 1048689006587 anticodon binding site; other site 1048689006588 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 1048689006589 Flagellar protein FlhE; Region: FlhE; pfam06366 1048689006590 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1048689006591 FHIPEP family; Region: FHIPEP; pfam00771 1048689006592 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1048689006593 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1048689006594 chemotaxis regulator CheZ; Provisional; Region: PRK11166 1048689006595 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 1048689006596 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1048689006597 active site 1048689006598 phosphorylation site [posttranslational modification] 1048689006599 intermolecular recognition site; other site 1048689006600 dimerization interface [polypeptide binding]; other site 1048689006601 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1048689006602 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1048689006603 active site 1048689006604 phosphorylation site [posttranslational modification] 1048689006605 intermolecular recognition site; other site 1048689006606 dimerization interface [polypeptide binding]; other site 1048689006607 CheB methylesterase; Region: CheB_methylest; pfam01339 1048689006608 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 1048689006609 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1048689006610 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1048689006611 S-adenosylmethionine binding site [chemical binding]; other site 1048689006612 potential frameshift: common BLAST hit: gi|291283067|ref|YP_003499885.1| methyl-accepting chemotaxis protein IV 1048689006613 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 1048689006614 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1048689006615 dimer interface [polypeptide binding]; other site 1048689006616 ligand binding site [chemical binding]; other site 1048689006617 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1048689006618 dimerization interface [polypeptide binding]; other site 1048689006619 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1048689006620 dimer interface [polypeptide binding]; other site 1048689006621 putative CheW interface [polypeptide binding]; other site 1048689006622 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1048689006623 putative CheA interaction surface; other site 1048689006624 chemotaxis protein CheA; Provisional; Region: PRK10547 1048689006625 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1048689006626 putative binding surface; other site 1048689006627 active site 1048689006628 CheY binding; Region: CheY-binding; pfam09078 1048689006629 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1048689006630 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1048689006631 ATP binding site [chemical binding]; other site 1048689006632 Mg2+ binding site [ion binding]; other site 1048689006633 G-X-G motif; other site 1048689006634 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1048689006635 flagellar motor protein MotB; Validated; Region: motB; PRK09041 1048689006636 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1048689006637 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1048689006638 ligand binding site [chemical binding]; other site 1048689006639 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1048689006640 flagellar motor protein MotA; Validated; Region: PRK09110 1048689006641 transcriptional activator FlhC; Provisional; Region: PRK12722 1048689006642 transcriptional activator FlhD; Provisional; Region: PRK02909 1048689006643 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1048689006644 Ligand Binding Site [chemical binding]; other site 1048689006645 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 1048689006646 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1048689006647 active site 1048689006648 homotetramer interface [polypeptide binding]; other site 1048689006649 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187 1048689006650 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 1048689006651 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1048689006652 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1048689006653 TM-ABC transporter signature motif; other site 1048689006654 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 1048689006655 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1048689006656 Walker A/P-loop; other site 1048689006657 ATP binding site [chemical binding]; other site 1048689006658 Q-loop/lid; other site 1048689006659 ABC transporter signature motif; other site 1048689006660 Walker B; other site 1048689006661 D-loop; other site 1048689006662 H-loop/switch region; other site 1048689006663 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1048689006664 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 1048689006665 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 1048689006666 ligand binding site [chemical binding]; other site 1048689006667 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1048689006668 Ferritin-like domain; Region: Ferritin; pfam00210 1048689006669 ferroxidase diiron center [ion binding]; other site 1048689006670 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 1048689006671 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1048689006672 Ferritin-like domain; Region: Ferritin; pfam00210 1048689006673 ferroxidase diiron center [ion binding]; other site 1048689006674 probable metal-binding protein; Region: matur_matur; TIGR03853 1048689006675 tyrosine transporter TyrP; Provisional; Region: PRK15132 1048689006676 aromatic amino acid transport protein; Region: araaP; TIGR00837 1048689006677 hypothetical protein; Provisional; Region: PRK10396 1048689006678 yecA family protein; Region: ygfB_yecA; TIGR02292 1048689006679 SEC-C motif; Region: SEC-C; pfam02810 1048689006680 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 1048689006681 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1048689006682 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1048689006683 GIY-YIG motif/motif A; other site 1048689006684 active site 1048689006685 catalytic site [active] 1048689006686 putative DNA binding site [nucleotide binding]; other site 1048689006687 metal binding site [ion binding]; metal-binding site 1048689006688 UvrB/uvrC motif; Region: UVR; pfam02151 1048689006689 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1048689006690 Helix-hairpin-helix motif; Region: HHH; pfam00633 1048689006691 response regulator; Provisional; Region: PRK09483 1048689006692 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1048689006693 active site 1048689006694 phosphorylation site [posttranslational modification] 1048689006695 intermolecular recognition site; other site 1048689006696 dimerization interface [polypeptide binding]; other site 1048689006697 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1048689006698 DNA binding residues [nucleotide binding] 1048689006699 dimerization interface [polypeptide binding]; other site 1048689006700 hypothetical protein; Provisional; Region: PRK10613 1048689006701 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 1048689006702 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1048689006703 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1048689006704 DNA binding residues [nucleotide binding] 1048689006705 dimerization interface [polypeptide binding]; other site 1048689006706 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 1048689006707 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1048689006708 Walker A/P-loop; other site 1048689006709 ATP binding site [chemical binding]; other site 1048689006710 Q-loop/lid; other site 1048689006711 ABC transporter signature motif; other site 1048689006712 Walker B; other site 1048689006713 D-loop; other site 1048689006714 H-loop/switch region; other site 1048689006715 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1048689006716 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048689006717 dimer interface [polypeptide binding]; other site 1048689006718 conserved gate region; other site 1048689006719 putative PBP binding loops; other site 1048689006720 ABC-ATPase subunit interface; other site 1048689006721 D-cysteine desulfhydrase; Validated; Region: PRK03910 1048689006722 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 1048689006723 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048689006724 catalytic residue [active] 1048689006725 cystine transporter subunit; Provisional; Region: PRK11260 1048689006726 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1048689006727 substrate binding pocket [chemical binding]; other site 1048689006728 membrane-bound complex binding site; other site 1048689006729 hinge residues; other site 1048689006730 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 1048689006731 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 1048689006732 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1048689006733 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1048689006734 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1048689006735 DNA binding residues [nucleotide binding] 1048689006736 flagellin; Validated; Region: PRK08026 1048689006737 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1048689006738 Flagellin protein; Region: FliC; pfam12445 1048689006739 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1048689006740 flagellar capping protein; Reviewed; Region: fliD; PRK08032 1048689006741 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1048689006742 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1048689006743 Flagellar protein FliS; Region: FliS; cl00654 1048689006744 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 1048689006745 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 1048689006746 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 1048689006747 active site 1048689006748 Na/Ca binding site [ion binding]; other site 1048689006749 catalytic site [active] 1048689006750 lipoprotein; Provisional; Region: PRK10397 1048689006751 putative inner membrane protein; Provisional; Region: PRK11099 1048689006752 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 1048689006753 CPxP motif; other site 1048689006754 hypothetical protein; Provisional; Region: PRK09951 1048689006755 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1048689006756 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1048689006757 Coenzyme A binding pocket [chemical binding]; other site 1048689006758 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 1048689006759 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1048689006760 Coenzyme A binding pocket [chemical binding]; other site 1048689006761 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 1048689006762 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 1048689006763 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 1048689006764 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 1048689006765 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1048689006766 flagellar motor switch protein FliG; Region: fliG; TIGR00207 1048689006767 FliG C-terminal domain; Region: FliG_C; pfam01706 1048689006768 flagellar assembly protein H; Validated; Region: fliH; PRK05687 1048689006769 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 1048689006770 Flagellar assembly protein FliH; Region: FliH; pfam02108 1048689006771 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 1048689006772 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1048689006773 Walker A motif/ATP binding site; other site 1048689006774 Walker B motif; other site 1048689006775 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 1048689006776 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 1048689006777 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 1048689006778 flagellar hook-length control protein; Provisional; Region: PRK10118 1048689006779 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 1048689006780 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1048689006781 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1048689006782 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 1048689006783 flagellar motor switch protein; Validated; Region: fliN; PRK05698 1048689006784 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 1048689006785 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1048689006786 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1048689006787 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1048689006788 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 1048689006789 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1048689006790 DNA binding residues [nucleotide binding] 1048689006791 dimerization interface [polypeptide binding]; other site 1048689006792 hypothetical protein; Provisional; Region: PRK10708 1048689006793 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 1048689006794 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 1048689006795 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1048689006796 active site 1048689006797 motif I; other site 1048689006798 motif II; other site 1048689006799 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 1048689006800 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1048689006801 metal binding site [ion binding]; metal-binding site 1048689006802 active site 1048689006803 I-site; other site 1048689006804 Uncharacterized small protein [Function unknown]; Region: COG5475 1048689006805 hypothetical protein; Provisional; Region: PRK10062 1048689006806 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 1048689006807 EamA-like transporter family; Region: EamA; pfam00892 1048689006808 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 1048689006809 additional DNA contacts [nucleotide binding]; other site 1048689006810 mismatch recognition site; other site 1048689006811 active site 1048689006812 zinc binding site [ion binding]; other site 1048689006813 DNA intercalation site [nucleotide binding]; other site 1048689006814 DNA cytosine methylase; Provisional; Region: PRK10458 1048689006815 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1048689006816 cofactor binding site; other site 1048689006817 DNA binding site [nucleotide binding] 1048689006818 substrate interaction site [chemical binding]; other site 1048689006819 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1048689006820 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1048689006821 Zn2+ binding site [ion binding]; other site 1048689006822 Mg2+ binding site [ion binding]; other site 1048689006823 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 1048689006824 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1048689006825 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1048689006826 trimer interface [polypeptide binding]; other site 1048689006827 eyelet of channel; other site 1048689006828 chaperone protein HchA; Provisional; Region: PRK04155 1048689006829 Type 1 glutamine amidotransferase (GATase1)-like domain found in Escherichia coli Hsp31 protein (EcHsp31); Region: GATase1_EcHsp31_like; cd03148 1048689006830 dimer interface [polypeptide binding]; other site 1048689006831 metal binding site [ion binding]; metal-binding site 1048689006832 potential oxyanion hole; other site 1048689006833 potential catalytic triad [active] 1048689006834 conserved cys residue [active] 1048689006835 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1048689006836 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1048689006837 dimer interface [polypeptide binding]; other site 1048689006838 phosphorylation site [posttranslational modification] 1048689006839 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1048689006840 ATP binding site [chemical binding]; other site 1048689006841 Mg2+ binding site [ion binding]; other site 1048689006842 G-X-G motif; other site 1048689006843 transcriptional regulatory protein YedW; Provisional; Region: PRK11517 1048689006844 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1048689006845 active site 1048689006846 phosphorylation site [posttranslational modification] 1048689006847 intermolecular recognition site; other site 1048689006848 dimerization interface [polypeptide binding]; other site 1048689006849 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1048689006850 DNA binding site [nucleotide binding] 1048689006851 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1048689006852 active site 1048689006853 homotetramer interface [polypeptide binding]; other site 1048689006854 TMAO/DMSO reductase; Reviewed; Region: PRK05363 1048689006855 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 1048689006856 Moco binding site; other site 1048689006857 metal coordination site [ion binding]; other site 1048689006858 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 1048689006859 zinc/cadmium-binding protein; Provisional; Region: PRK10306 1048689006860 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1048689006861 prophage Cp9 1048689006862 AvrPphF-ORF-2; Region: AvrPphF-ORF-2; pfam09143 1048689006863 EspF protein repeat; Region: EspF; pfam04806 1048689006864 EspF protein repeat; Region: EspF; pfam04806 1048689006865 EspF protein repeat; Region: EspF; pfam04806 1048689006866 EspF protein repeat; Region: EspF; pfam04806 1048689006867 EspF protein repeat; Region: EspF; pfam04806 1048689006868 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 1048689006869 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 1048689006870 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 1048689006871 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 1048689006872 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 1048689006873 Phage-related protein, tail component [Function unknown]; Region: COG4733 1048689006874 Putative phage tail protein; Region: Phage-tail_3; pfam13550 1048689006875 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 1048689006876 Fibronectin type III protein; Region: DUF3672; pfam12421 1048689006877 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1048689006878 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1048689006879 E-class dimer interface [polypeptide binding]; other site 1048689006880 P-class dimer interface [polypeptide binding]; other site 1048689006881 active site 1048689006882 Cu2+ binding site [ion binding]; other site 1048689006883 Zn2+ binding site [ion binding]; other site 1048689006884 Phage-related protein, tail component [Function unknown]; Region: COG4723 1048689006885 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 1048689006886 MPN+ (JAMM) motif; other site 1048689006887 Zinc-binding site [ion binding]; other site 1048689006888 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1048689006889 NlpC/P60 family; Region: NLPC_P60; cl17555 1048689006890 Phage-related protein [Function unknown]; Region: gp18; COG4672 1048689006891 Phage-related protein [Function unknown]; Region: COG4718 1048689006892 Phage-related minor tail protein [Function unknown]; Region: COG5281 1048689006893 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 1048689006894 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 1048689006895 Minor tail protein T; Region: Phage_tail_T; cl05636 1048689006896 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894 1048689006897 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 1048689006898 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 1048689006899 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 1048689006900 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 1048689006901 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 1048689006902 DNA packaging protein FI; Region: Packaging_FI; pfam14000 1048689006903 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 1048689006904 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 1048689006905 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 1048689006906 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1048689006907 tandem repeat interface [polypeptide binding]; other site 1048689006908 oligomer interface [polypeptide binding]; other site 1048689006909 active site residues [active] 1048689006910 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 1048689006911 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 1048689006912 gpW; Region: gpW; pfam02831 1048689006913 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 1048689006914 Phage DNA packaging protein, Nu1 subunit of terminase [DNA replication, recombination, and repair]; Region: COG4220 1048689006915 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 1048689006916 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1048689006917 catalytic residues [active] 1048689006918 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 1048689006919 Lysis protein S; Region: Lysis_S; pfam04971 1048689006920 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 1048689006921 Domain of unknown function (DUF303); Region: DUF303; pfam03629 1048689006922 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1048689006923 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1048689006924 CAAX protease self-immunity; Region: Abi; pfam02517 1048689006925 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 1048689006926 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 1048689006927 Protein of unknown function (DUF968); Region: DUF968; pfam06147 1048689006928 adenylosuccinate lyase; Provisional; Region: PRK09285 1048689006929 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1048689006930 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1048689006931 non-specific DNA binding site [nucleotide binding]; other site 1048689006932 salt bridge; other site 1048689006933 sequence-specific DNA binding site [nucleotide binding]; other site 1048689006934 Domain of unknown function (DUF955); Region: DUF955; cl01076 1048689006935 Hok/gef family; Region: HOK_GEF; pfam01848 1048689006936 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1048689006937 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 1048689006938 primosomal protein DnaI; Provisional; Region: PRK02854 1048689006939 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 1048689006940 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 1048689006941 transcriptional repressor DicA; Reviewed; Region: PRK09706 1048689006942 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1048689006943 non-specific DNA binding site [nucleotide binding]; other site 1048689006944 salt bridge; other site 1048689006945 sequence-specific DNA binding site [nucleotide binding]; other site 1048689006946 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 1048689006947 DicB protein; Region: DicB; pfam05358 1048689006948 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 1048689006949 exonuclease VIII; Reviewed; Region: PRK09709 1048689006950 Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630 1048689006951 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1048689006952 active site 1048689006953 substrate binding site [chemical binding]; other site 1048689006954 catalytic site [active] 1048689006955 Domain of unknown function (DUF4224); Region: DUF4224; pfam13986 1048689006956 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1048689006957 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1048689006958 active site 1048689006959 DNA binding site [nucleotide binding] 1048689006960 Int/Topo IB signature motif; other site 1048689006961 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 1048689006962 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 1048689006963 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 1048689006964 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 1048689006965 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1048689006966 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1048689006967 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1048689006968 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1048689006969 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1048689006970 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1048689006971 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1048689006972 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1048689006973 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 1048689006974 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 1048689006975 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 1048689006976 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1048689006977 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 1048689006978 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1048689006979 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1048689006980 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1048689006981 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1048689006982 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1048689006983 shikimate transporter; Provisional; Region: PRK09952 1048689006984 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689006985 putative substrate translocation pore; other site 1048689006986 AMP nucleosidase; Provisional; Region: PRK08292 1048689006987 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 1048689006988 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1048689006989 hypothetical protein; Provisional; Region: PRK12378 1048689006990 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 1048689006991 putative efflux protein, MATE family; Region: matE; TIGR00797 1048689006992 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 1048689006993 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1048689006994 The C-terminal substrate binding domain of LysR-type transcriptional regulator Cbl, which is required for expression of sulfate starvation-inducible (ssi) genes, contains the type 2 periplasmic binding fold; Region: PBP2_Cbl; cd08444 1048689006995 putative substrate binding site [chemical binding]; other site 1048689006996 dimerization interface [polypeptide binding]; other site 1048689006997 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 1048689006998 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1048689006999 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 1048689007000 putative dimerization interface [polypeptide binding]; other site 1048689007001 L,D-transpeptidase; Provisional; Region: PRK10190 1048689007002 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1048689007003 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1048689007004 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1048689007005 putative dimer interface [polypeptide binding]; other site 1048689007006 active site pocket [active] 1048689007007 putative cataytic base [active] 1048689007008 cobalamin 5'-phosphate synthase/cobalamin synthase; Region: cobS; TIGR00317 1048689007009 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1048689007010 homotrimer interface [polypeptide binding]; other site 1048689007011 Walker A motif; other site 1048689007012 GTP binding site [chemical binding]; other site 1048689007013 Walker B motif; other site 1048689007014 phage-like element CpLE1 1048689007015 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1048689007016 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1048689007017 N-terminal plug; other site 1048689007018 ligand-binding site [chemical binding]; other site 1048689007019 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1048689007020 ParB-like nuclease domain; Region: ParBc; cl02129 1048689007021 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 1048689007022 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1048689007023 Transposase; Region: HTH_Tnp_1; cl17663 1048689007024 HTH-like domain; Region: HTH_21; pfam13276 1048689007025 Integrase core domain; Region: rve; pfam00665 1048689007026 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1048689007027 Integrase core domain; Region: rve_3; pfam13683 1048689007028 Predicted GTPase [General function prediction only]; Region: COG3596 1048689007029 YfjP GTPase; Region: YfjP; cd11383 1048689007030 G1 box; other site 1048689007031 GTP/Mg2+ binding site [chemical binding]; other site 1048689007032 Switch I region; other site 1048689007033 G2 box; other site 1048689007034 Switch II region; other site 1048689007035 G3 box; other site 1048689007036 G4 box; other site 1048689007037 G5 box; other site 1048689007038 hypothetical protein; Provisional; Region: PRK09866 1048689007039 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1048689007040 G1 box; other site 1048689007041 GTP/Mg2+ binding site [chemical binding]; other site 1048689007042 G2 box; other site 1048689007043 Switch I region; other site 1048689007044 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1048689007045 G3 box; other site 1048689007046 Switch II region; other site 1048689007047 GTP/Mg2+ binding site [chemical binding]; other site 1048689007048 G4 box; other site 1048689007049 G5 box; other site 1048689007050 YjcZ-like protein; Region: YjcZ; pfam13990 1048689007051 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1048689007052 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1048689007053 nucleophile elbow; other site 1048689007054 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 1048689007055 Domain of unknown function (DUF932); Region: DUF932; pfam06067 1048689007056 Antirestriction protein; Region: Antirestrict; pfam03230 1048689007057 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 1048689007058 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1048689007059 MPN+ (JAMM) motif; other site 1048689007060 Zinc-binding site [ion binding]; other site 1048689007061 Protein of unknown function (DUF987); Region: DUF987; pfam06174 1048689007062 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 1048689007063 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 1048689007064 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1048689007065 Switch II region; other site 1048689007066 G4 box; other site 1048689007067 G5 box; other site 1048689007068 hypothetical protein; Provisional; Region: PRK05423 1048689007069 Predicted membrane protein [Function unknown]; Region: COG1289 1048689007070 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1048689007071 DNA gyrase inhibitor; Provisional; Region: PRK10016 1048689007072 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 1048689007073 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1048689007074 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1048689007075 exonuclease I; Provisional; Region: sbcB; PRK11779 1048689007076 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 1048689007077 active site 1048689007078 catalytic site [active] 1048689007079 substrate binding site [chemical binding]; other site 1048689007080 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 1048689007081 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1048689007082 CPxP motif; other site 1048689007083 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 1048689007084 Sulphur transport; Region: Sulf_transp; pfam04143 1048689007085 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1048689007086 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1048689007087 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1048689007088 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1048689007089 dimerization interface [polypeptide binding]; other site 1048689007090 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1048689007091 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 1048689007092 putative NAD(P) binding site [chemical binding]; other site 1048689007093 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 1048689007094 antitoxin YefM; Provisional; Region: PRK11409 1048689007095 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1048689007096 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1048689007097 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1048689007098 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 1048689007099 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1048689007100 NAD binding site [chemical binding]; other site 1048689007101 dimerization interface [polypeptide binding]; other site 1048689007102 product binding site; other site 1048689007103 substrate binding site [chemical binding]; other site 1048689007104 zinc binding site [ion binding]; other site 1048689007105 catalytic residues [active] 1048689007106 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 1048689007107 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1048689007108 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048689007109 homodimer interface [polypeptide binding]; other site 1048689007110 catalytic residue [active] 1048689007111 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 1048689007112 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1048689007113 active site 1048689007114 motif I; other site 1048689007115 motif II; other site 1048689007116 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1048689007117 putative active site pocket [active] 1048689007118 4-fold oligomerization interface [polypeptide binding]; other site 1048689007119 metal binding residues [ion binding]; metal-binding site 1048689007120 3-fold/trimer interface [polypeptide binding]; other site 1048689007121 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 1048689007122 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1048689007123 putative active site [active] 1048689007124 oxyanion strand; other site 1048689007125 catalytic triad [active] 1048689007126 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1048689007127 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1048689007128 catalytic residues [active] 1048689007129 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1048689007130 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1048689007131 substrate binding site [chemical binding]; other site 1048689007132 glutamase interaction surface [polypeptide binding]; other site 1048689007133 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 1048689007134 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1048689007135 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1048689007136 metal binding site [ion binding]; metal-binding site 1048689007137 chain length determinant protein WzzB; Provisional; Region: PRK15471 1048689007138 Chain length determinant protein; Region: Wzz; cl15801 1048689007139 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 1048689007140 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1048689007141 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1048689007142 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1048689007143 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1048689007144 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1048689007145 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1048689007146 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1048689007147 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 1048689007148 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1048689007149 inhibitor-cofactor binding pocket; inhibition site 1048689007150 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048689007151 catalytic residue [active] 1048689007152 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1048689007153 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 1048689007154 NAD(P) binding site [chemical binding]; other site 1048689007155 active site 1048689007156 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1048689007157 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1048689007158 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1048689007159 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1048689007160 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1048689007161 active site 1048689007162 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1048689007163 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1048689007164 active site 1048689007165 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1048689007166 Alpha-1,2-fucosyltransferase; Region: Fut1_Fut2_like; cd11301 1048689007167 GDP-Fucose binding site [chemical binding]; other site 1048689007168 phosphomannomutase CpsG; Provisional; Region: PRK15414 1048689007169 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1048689007170 active site 1048689007171 substrate binding site [chemical binding]; other site 1048689007172 metal binding site [ion binding]; metal-binding site 1048689007173 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 1048689007174 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1048689007175 Substrate binding site; other site 1048689007176 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 1048689007177 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 1048689007178 active site 1048689007179 GDP-Mannose binding site [chemical binding]; other site 1048689007180 dimer interface [polypeptide binding]; other site 1048689007181 modified nudix motif 1048689007182 metal binding site [ion binding]; metal-binding site 1048689007183 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1048689007184 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1048689007185 NADP-binding site; other site 1048689007186 homotetramer interface [polypeptide binding]; other site 1048689007187 substrate binding site [chemical binding]; other site 1048689007188 homodimer interface [polypeptide binding]; other site 1048689007189 active site 1048689007190 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1048689007191 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 1048689007192 putative ADP-binding pocket [chemical binding]; other site 1048689007193 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1048689007194 active site 1048689007195 tetramer interface; other site 1048689007196 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 1048689007197 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1048689007198 putative NAD(P) binding site [chemical binding]; other site 1048689007199 active site 1048689007200 putative substrate binding site [chemical binding]; other site 1048689007201 putative colanic acid biosynthesis protein; Provisional; Region: wcaM; PRK10123 1048689007202 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 1048689007203 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 1048689007204 putative ADP-binding pocket [chemical binding]; other site 1048689007205 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 1048689007206 colanic acid biosynthesis pyruvyl transferase WcaK; Region: wcaK; TIGR04006 1048689007207 colanic acid exporter; Provisional; Region: PRK10459 1048689007208 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1048689007209 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 1048689007210 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 1048689007211 phosphomannomutase CpsG; Provisional; Region: PRK15414 1048689007212 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1048689007213 active site 1048689007214 substrate binding site [chemical binding]; other site 1048689007215 metal binding site [ion binding]; metal-binding site 1048689007216 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 1048689007217 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1048689007218 Substrate binding site; other site 1048689007219 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 1048689007220 colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007 1048689007221 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1048689007222 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 1048689007223 active site 1048689007224 GDP-Mannose binding site [chemical binding]; other site 1048689007225 dimer interface [polypeptide binding]; other site 1048689007226 modified nudix motif 1048689007227 metal binding site [ion binding]; metal-binding site 1048689007228 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 1048689007229 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 1048689007230 NADP binding site [chemical binding]; other site 1048689007231 active site 1048689007232 putative substrate binding site [chemical binding]; other site 1048689007233 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1048689007234 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1048689007235 NADP-binding site; other site 1048689007236 homotetramer interface [polypeptide binding]; other site 1048689007237 substrate binding site [chemical binding]; other site 1048689007238 homodimer interface [polypeptide binding]; other site 1048689007239 active site 1048689007240 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 1048689007241 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 1048689007242 putative trimer interface [polypeptide binding]; other site 1048689007243 putative active site [active] 1048689007244 putative substrate binding site [chemical binding]; other site 1048689007245 putative CoA binding site [chemical binding]; other site 1048689007246 putative glycosyl transferase; Provisional; Region: PRK10063 1048689007247 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 1048689007248 metal-binding site 1048689007249 putative colanic acid polymerase WcaD; Region: WcaD; TIGR04010 1048689007250 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1048689007251 colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015 1048689007252 putative acyl transferase; Provisional; Region: PRK10191 1048689007253 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1048689007254 trimer interface [polypeptide binding]; other site 1048689007255 active site 1048689007256 substrate binding site [chemical binding]; other site 1048689007257 CoA binding site [chemical binding]; other site 1048689007258 putative glycosyl transferase; Provisional; Region: PRK10018 1048689007259 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1048689007260 active site 1048689007261 tyrosine kinase; Provisional; Region: PRK11519 1048689007262 Chain length determinant protein; Region: Wzz; pfam02706 1048689007263 Chain length determinant protein; Region: Wzz; cl15801 1048689007264 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1048689007265 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1048689007266 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1048689007267 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1048689007268 active site 1048689007269 polysaccharide export protein Wza; Provisional; Region: PRK15078 1048689007270 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1048689007271 SLBB domain; Region: SLBB; pfam10531 1048689007272 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1048689007273 FOG: CBS domain [General function prediction only]; Region: COG0517 1048689007274 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1048689007275 Transporter associated domain; Region: CorC_HlyC; smart01091 1048689007276 Phage-related protein [Function unknown]; Region: COG4679 1048689007277 Uncharacterized conserved small protein [Function unknown]; Region: COG5606 1048689007278 putative assembly protein; Provisional; Region: PRK10833 1048689007279 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1048689007280 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1048689007281 trimer interface [polypeptide binding]; other site 1048689007282 active site 1048689007283 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1048689007284 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1048689007285 ATP-binding site [chemical binding]; other site 1048689007286 Sugar specificity; other site 1048689007287 Pyrimidine base specificity; other site 1048689007288 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 1048689007289 putative diguanylate cyclase; Provisional; Region: PRK09776 1048689007290 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1048689007291 putative active site [active] 1048689007292 heme pocket [chemical binding]; other site 1048689007293 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1048689007294 putative active site [active] 1048689007295 heme pocket [chemical binding]; other site 1048689007296 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1048689007297 putative active site [active] 1048689007298 heme pocket [chemical binding]; other site 1048689007299 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1048689007300 metal binding site [ion binding]; metal-binding site 1048689007301 active site 1048689007302 I-site; other site 1048689007303 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1048689007304 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 1048689007305 AlkA N-terminal domain; Region: AlkA_N; smart01009 1048689007306 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1048689007307 minor groove reading motif; other site 1048689007308 helix-hairpin-helix signature motif; other site 1048689007309 substrate binding pocket [chemical binding]; other site 1048689007310 active site 1048689007311 putative chaperone; Provisional; Region: PRK11678 1048689007312 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 1048689007313 nucleotide binding site [chemical binding]; other site 1048689007314 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1048689007315 SBD interface [polypeptide binding]; other site 1048689007316 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248 1048689007317 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1048689007318 substrate binding site [chemical binding]; other site 1048689007319 activation loop (A-loop); other site 1048689007320 Protein phosphatase 2C; Region: PP2C_2; pfam13672 1048689007321 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 1048689007322 metal ion-dependent adhesion site (MIDAS); other site 1048689007323 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 1048689007324 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1048689007325 HlyD family secretion protein; Region: HlyD_3; pfam13437 1048689007326 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 1048689007327 Protein export membrane protein; Region: SecD_SecF; cl14618 1048689007328 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 1048689007329 putative transporter; Provisional; Region: PRK10504 1048689007330 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689007331 putative substrate translocation pore; other site 1048689007332 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689007333 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 1048689007334 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1048689007335 dimerization interface [polypeptide binding]; other site 1048689007336 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1048689007337 dimer interface [polypeptide binding]; other site 1048689007338 phosphorylation site [posttranslational modification] 1048689007339 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1048689007340 ATP binding site [chemical binding]; other site 1048689007341 Mg2+ binding site [ion binding]; other site 1048689007342 G-X-G motif; other site 1048689007343 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 1048689007344 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1048689007345 active site 1048689007346 phosphorylation site [posttranslational modification] 1048689007347 intermolecular recognition site; other site 1048689007348 dimerization interface [polypeptide binding]; other site 1048689007349 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1048689007350 DNA binding site [nucleotide binding] 1048689007351 Uncharacterized conserved protein [Function unknown]; Region: COG3422 1048689007352 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 1048689007353 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 1048689007354 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 1048689007355 putative protease; Provisional; Region: PRK15452 1048689007356 Peptidase family U32; Region: Peptidase_U32; pfam01136 1048689007357 lipid kinase; Reviewed; Region: PRK13054 1048689007358 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1048689007359 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 1048689007360 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1048689007361 motif II; other site 1048689007362 polyol permease family; Region: 2A0118; TIGR00897 1048689007363 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689007364 putative substrate translocation pore; other site 1048689007365 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1048689007366 N- and C-terminal domain interface [polypeptide binding]; other site 1048689007367 D-xylulose kinase; Region: XylB; TIGR01312 1048689007368 active site 1048689007369 MgATP binding site [chemical binding]; other site 1048689007370 catalytic site [active] 1048689007371 metal binding site [ion binding]; metal-binding site 1048689007372 xylulose binding site [chemical binding]; other site 1048689007373 homodimer interface [polypeptide binding]; other site 1048689007374 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1048689007375 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1048689007376 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1048689007377 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1048689007378 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 1048689007379 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1048689007380 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1048689007381 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1048689007382 DNA binding site [nucleotide binding] 1048689007383 domain linker motif; other site 1048689007384 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 1048689007385 dimerization interface [polypeptide binding]; other site 1048689007386 ligand binding site [chemical binding]; other site 1048689007387 potential frameshift: common BLAST hit: gi|291283334|ref|YP_003500152.1| ribitol dehydrogenase 1048689007388 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 1048689007389 FGGY-family pentulose kinase; Region: 5C_CHO_kinase; TIGR01315 1048689007390 N- and C-terminal domain interface [polypeptide binding]; other site 1048689007391 active site 1048689007392 MgATP binding site [chemical binding]; other site 1048689007393 catalytic site [active] 1048689007394 metal binding site [ion binding]; metal-binding site 1048689007395 carbohydrate binding site [chemical binding]; other site 1048689007396 putative homodimer interface [polypeptide binding]; other site 1048689007397 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1048689007398 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1048689007399 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1048689007400 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 1048689007401 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 1048689007402 putative NAD(P) binding site [chemical binding]; other site 1048689007403 catalytic Zn binding site [ion binding]; other site 1048689007404 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 1048689007405 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1048689007406 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1048689007407 active site 1048689007408 P-loop; other site 1048689007409 phosphorylation site [posttranslational modification] 1048689007410 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1048689007411 active site 1048689007412 phosphorylation site [posttranslational modification] 1048689007413 D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052 1048689007414 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1048689007415 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1048689007416 intersubunit interface [polypeptide binding]; other site 1048689007417 active site 1048689007418 zinc binding site [ion binding]; other site 1048689007419 Na+ binding site [ion binding]; other site 1048689007420 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 1048689007421 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1048689007422 putative active site; other site 1048689007423 catalytic residue [active] 1048689007424 nucleoside transporter; Region: 2A0110; TIGR00889 1048689007425 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689007426 putative substrate translocation pore; other site 1048689007427 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 1048689007428 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1048689007429 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1048689007430 substrate binding site [chemical binding]; other site 1048689007431 ATP binding site [chemical binding]; other site 1048689007432 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1048689007433 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1048689007434 DNA-binding site [nucleotide binding]; DNA binding site 1048689007435 UTRA domain; Region: UTRA; pfam07702 1048689007436 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 1048689007437 YegX is an uncharacterized bacterial protein with a glycosyl hydrolase family 25 (GH25) catalytic domain that is similar in sequence to the CH-type (Chalaropsis-type) lysozymes of the GH25 family of endolysins; Region: GH25_YegX-like; cd06524 1048689007438 active site 1048689007439 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1048689007440 dimer interface [polypeptide binding]; other site 1048689007441 substrate binding site [chemical binding]; other site 1048689007442 ATP binding site [chemical binding]; other site 1048689007443 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1048689007444 substrate binding site [chemical binding]; other site 1048689007445 multimerization interface [polypeptide binding]; other site 1048689007446 ATP binding site [chemical binding]; other site 1048689007447 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 1048689007448 putative metal binding site [ion binding]; other site 1048689007449 putative homodimer interface [polypeptide binding]; other site 1048689007450 putative homotetramer interface [polypeptide binding]; other site 1048689007451 putative homodimer-homodimer interface [polypeptide binding]; other site 1048689007452 putative allosteric switch controlling residues; other site 1048689007453 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 1048689007454 Predicted integral membrane protein [Function unknown]; Region: COG5455 1048689007455 putative fimbrial-like adhesin protein StcD; Provisional; Region: PRK15252 1048689007456 putative fimbrial biosynthesis regulatory protein; Provisional; Region: PRK15216 1048689007457 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1048689007458 PapC C-terminal domain; Region: PapC_C; pfam13953 1048689007459 PapC N-terminal domain; Region: PapC_N; pfam13954 1048689007460 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1048689007461 potential frameshift: common BLAST hit: gi|218695728|ref|YP_002403395.1| putative membrane-associated pilin chaperone 1048689007462 Fimbrial protein; Region: Fimbrial; cl01416 1048689007463 Protein of unknown function (DUF2574); Region: DUF2574; pfam10836 1048689007464 antiporter inner membrane protein; Provisional; Region: PRK11670 1048689007465 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1048689007466 Walker A motif; other site 1048689007467 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 1048689007468 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1048689007469 active site 1048689007470 HIGH motif; other site 1048689007471 KMSKS motif; other site 1048689007472 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1048689007473 tRNA binding surface [nucleotide binding]; other site 1048689007474 anticodon binding site; other site 1048689007475 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1048689007476 dimer interface [polypeptide binding]; other site 1048689007477 putative tRNA-binding site [nucleotide binding]; other site 1048689007478 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 1048689007479 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 1048689007480 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 1048689007481 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 1048689007482 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 1048689007483 MoxR-like ATPases [General function prediction only]; Region: COG0714 1048689007484 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1048689007485 Walker A motif; other site 1048689007486 ATP binding site [chemical binding]; other site 1048689007487 Walker B motif; other site 1048689007488 arginine finger; other site 1048689007489 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 1048689007490 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 1048689007491 metal ion-dependent adhesion site (MIDAS); other site 1048689007492 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 1048689007493 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 1048689007494 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1048689007495 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1048689007496 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 1048689007497 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1048689007498 active site 1048689007499 phosphorylation site [posttranslational modification] 1048689007500 intermolecular recognition site; other site 1048689007501 dimerization interface [polypeptide binding]; other site 1048689007502 LytTr DNA-binding domain; Region: LytTR; pfam04397 1048689007503 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1048689007504 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1048689007505 GAF domain; Region: GAF; pfam01590 1048689007506 Histidine kinase; Region: His_kinase; pfam06580 1048689007507 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1048689007508 ATP binding site [chemical binding]; other site 1048689007509 Mg2+ binding site [ion binding]; other site 1048689007510 G-X-G motif; other site 1048689007511 interrupted mlrA (yehV) gene; sequence interrupted by a prophage 1048689007512 prophage Cp10 1048689007513 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 1048689007514 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 1048689007515 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 1048689007516 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 1048689007517 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 1048689007518 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 1048689007519 Phage-related protein, tail component [Function unknown]; Region: COG4733 1048689007520 Putative phage tail protein; Region: Phage-tail_3; pfam13550 1048689007521 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 1048689007522 Fibronectin type III protein; Region: DUF3672; pfam12421 1048689007523 Phage-related protein, tail component [Function unknown]; Region: COG4723 1048689007524 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 1048689007525 MPN+ (JAMM) motif; other site 1048689007526 Zinc-binding site [ion binding]; other site 1048689007527 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1048689007528 NlpC/P60 family; Region: NLPC_P60; cl17555 1048689007529 Phage-related protein [Function unknown]; Region: gp18; COG4672 1048689007530 Phage-related protein [Function unknown]; Region: COG4718 1048689007531 Phage-related minor tail protein [Function unknown]; Region: COG5281 1048689007532 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 1048689007533 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 1048689007534 Minor tail protein T; Region: Phage_tail_T; cl05636 1048689007535 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894 1048689007536 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 1048689007537 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 1048689007538 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 1048689007539 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 1048689007540 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 1048689007541 DNA packaging protein FI; Region: Packaging_FI; pfam14000 1048689007542 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 1048689007543 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 1048689007544 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 1048689007545 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1048689007546 tandem repeat interface [polypeptide binding]; other site 1048689007547 oligomer interface [polypeptide binding]; other site 1048689007548 active site residues [active] 1048689007549 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 1048689007550 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 1048689007551 gpW; Region: gpW; pfam02831 1048689007552 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 1048689007553 Phage DNA packaging protein, Nu1 subunit of terminase [DNA replication, recombination, and repair]; Region: COG4220 1048689007554 PerC transcriptional activator; Region: PerC; pfam06069 1048689007555 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 1048689007556 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1048689007557 catalytic residues [active] 1048689007558 Lysis protein S; Region: Lysis_S; pfam04971 1048689007559 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 1048689007560 Domain of unknown function (DUF303); Region: DUF303; pfam03629 1048689007561 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1048689007562 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1048689007563 DNA methylase; Region: N6_N4_Mtase; pfam01555 1048689007564 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1048689007565 Protein of unknown function (DUF1133); Region: DUF1133; pfam06576 1048689007566 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 1048689007567 Protein of unknown function (DUF968); Region: DUF968; pfam06147 1048689007568 replicative DNA helicase; Region: DnaB; TIGR00665 1048689007569 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1048689007570 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1048689007571 Walker A motif; other site 1048689007572 ATP binding site [chemical binding]; other site 1048689007573 Walker B motif; other site 1048689007574 DNA binding loops [nucleotide binding] 1048689007575 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1048689007576 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1048689007577 Walker A motif; other site 1048689007578 ATP binding site [chemical binding]; other site 1048689007579 Walker B motif; other site 1048689007580 arginine finger; other site 1048689007581 Ash protein family; Region: Phage_ASH; pfam10554 1048689007582 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 1048689007583 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 1048689007584 Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197 1048689007585 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1048689007586 non-specific DNA binding site [nucleotide binding]; other site 1048689007587 Predicted transcriptional regulator [Transcription]; Region: COG2932 1048689007588 salt bridge; other site 1048689007589 sequence-specific DNA binding site [nucleotide binding]; other site 1048689007590 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1048689007591 Catalytic site [active] 1048689007592 MarR family; Region: MarR_2; pfam12802 1048689007593 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 1048689007594 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 1048689007595 Protein of unknown function (DUF551); Region: DUF551; pfam04448 1048689007596 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 1048689007597 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 1048689007598 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 1048689007599 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1048689007600 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1048689007601 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 1048689007602 Int/Topo IB signature motif; other site 1048689007603 transcriptional regulator MirA; Provisional; Region: PRK15043 1048689007604 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1048689007605 hypothetical protein; Provisional; Region: PRK13681 1048689007606 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1048689007607 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048689007608 dimer interface [polypeptide binding]; other site 1048689007609 conserved gate region; other site 1048689007610 putative PBP binding loops; other site 1048689007611 ABC-ATPase subunit interface; other site 1048689007612 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1048689007613 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1048689007614 Walker A/P-loop; other site 1048689007615 ATP binding site [chemical binding]; other site 1048689007616 Q-loop/lid; other site 1048689007617 ABC transporter signature motif; other site 1048689007618 Walker B; other site 1048689007619 D-loop; other site 1048689007620 H-loop/switch region; other site 1048689007621 CBS domain; Region: CBS; pfam00571 1048689007622 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048689007623 dimer interface [polypeptide binding]; other site 1048689007624 conserved gate region; other site 1048689007625 ABC-ATPase subunit interface; other site 1048689007626 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1048689007627 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 1048689007628 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1048689007629 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1048689007630 D-lactate dehydrogenase; Provisional; Region: PRK11183 1048689007631 FAD binding domain; Region: FAD_binding_4; pfam01565 1048689007632 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 1048689007633 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 1048689007634 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1048689007635 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 1048689007636 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1048689007637 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1048689007638 oxidoreductase; Provisional; Region: PRK12743 1048689007639 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1048689007640 NAD(P) binding site [chemical binding]; other site 1048689007641 active site 1048689007642 multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459 1048689007643 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 1048689007644 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1048689007645 FMN binding site [chemical binding]; other site 1048689007646 active site 1048689007647 catalytic residues [active] 1048689007648 substrate binding site [chemical binding]; other site 1048689007649 salicylate hydroxylase; Provisional; Region: PRK08163 1048689007650 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1048689007651 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 1048689007652 maleylacetoacetate isomerase; Region: maiA; TIGR01262 1048689007653 C-terminal domain interface [polypeptide binding]; other site 1048689007654 GSH binding site (G-site) [chemical binding]; other site 1048689007655 putative dimer interface [polypeptide binding]; other site 1048689007656 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 1048689007657 dimer interface [polypeptide binding]; other site 1048689007658 N-terminal domain interface [polypeptide binding]; other site 1048689007659 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 1048689007660 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1048689007661 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1048689007662 gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272 1048689007663 Cupin domain; Region: Cupin_2; pfam07883 1048689007664 Cupin domain; Region: Cupin_2; cl17218 1048689007665 benzoate transport; Region: 2A0115; TIGR00895 1048689007666 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689007667 putative substrate translocation pore; other site 1048689007668 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1048689007669 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1048689007670 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1048689007671 dimerization interface [polypeptide binding]; other site 1048689007672 hypothetical protein; Provisional; Region: PRK01821 1048689007673 hypothetical protein; Provisional; Region: PRK10711 1048689007674 cytidine deaminase; Provisional; Region: PRK09027 1048689007675 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1048689007676 active site 1048689007677 catalytic motif [active] 1048689007678 Zn binding site [ion binding]; other site 1048689007679 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1048689007680 active site 1048689007681 catalytic motif [active] 1048689007682 Zn binding site [ion binding]; other site 1048689007683 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1048689007684 putative active site [active] 1048689007685 Protein of unknown function (DUF2542); Region: DUF2542; pfam10808 1048689007686 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 1048689007687 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1048689007688 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1048689007689 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 1048689007690 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 1048689007691 homodimer interface [polypeptide binding]; other site 1048689007692 active site 1048689007693 FMN binding site [chemical binding]; other site 1048689007694 substrate binding site [chemical binding]; other site 1048689007695 4Fe-4S binding domain; Region: Fer4; pfam00037 1048689007696 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1048689007697 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1048689007698 TM-ABC transporter signature motif; other site 1048689007699 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1048689007700 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 1048689007701 Walker A/P-loop; other site 1048689007702 ATP binding site [chemical binding]; other site 1048689007703 Q-loop/lid; other site 1048689007704 ABC transporter signature motif; other site 1048689007705 Walker B; other site 1048689007706 D-loop; other site 1048689007707 H-loop/switch region; other site 1048689007708 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1048689007709 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 1048689007710 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 1048689007711 ligand binding site [chemical binding]; other site 1048689007712 calcium binding site [ion binding]; other site 1048689007713 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 1048689007714 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1048689007715 DNA binding site [nucleotide binding] 1048689007716 domain linker motif; other site 1048689007717 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1048689007718 dimerization interface (closed form) [polypeptide binding]; other site 1048689007719 ligand binding site [chemical binding]; other site 1048689007720 Predicted membrane protein [Function unknown]; Region: COG2311 1048689007721 hypothetical protein; Provisional; Region: PRK10835 1048689007722 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1048689007723 homodecamer interface [polypeptide binding]; other site 1048689007724 GTP cyclohydrolase I; Provisional; Region: PLN03044 1048689007725 active site 1048689007726 putative catalytic site residues [active] 1048689007727 zinc binding site [ion binding]; other site 1048689007728 GTP-CH-I/GFRP interaction surface; other site 1048689007729 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 1048689007730 S-formylglutathione hydrolase; Region: PLN02442 1048689007731 catecholate siderophore receptor CirA; Provisional; Region: PRK10064 1048689007732 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1048689007733 N-terminal plug; other site 1048689007734 ligand-binding site [chemical binding]; other site 1048689007735 lysine transporter; Provisional; Region: PRK10836 1048689007736 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 1048689007737 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1048689007738 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1048689007739 putative dimerization interface [polypeptide binding]; other site 1048689007740 conserved hypothetical integral membrane protein; Region: TIGR00698 1048689007741 endonuclease IV; Provisional; Region: PRK01060 1048689007742 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1048689007743 AP (apurinic/apyrimidinic) site pocket; other site 1048689007744 DNA interaction; other site 1048689007745 Metal-binding active site; metal-binding site 1048689007746 putative kinase; Provisional; Region: PRK09954 1048689007747 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1048689007748 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 1048689007749 substrate binding site [chemical binding]; other site 1048689007750 ATP binding site [chemical binding]; other site 1048689007751 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1048689007752 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1048689007753 Nucleoside recognition; Region: Gate; pfam07670 1048689007754 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1048689007755 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1048689007756 active site 1048689007757 tetramer interface [polypeptide binding]; other site 1048689007758 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 1048689007759 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1048689007760 ligand binding site [chemical binding]; other site 1048689007761 flexible hinge region; other site 1048689007762 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1048689007763 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1048689007764 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1048689007765 Nucleoside recognition; Region: Gate; pfam07670 1048689007766 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1048689007767 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 1048689007768 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 1048689007769 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1048689007770 substrate binding site [chemical binding]; other site 1048689007771 ATP binding site [chemical binding]; other site 1048689007772 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 1048689007773 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 1048689007774 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1048689007775 active site 1048689007776 P-loop; other site 1048689007777 phosphorylation site [posttranslational modification] 1048689007778 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 1048689007779 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1048689007780 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1048689007781 putative substrate binding site [chemical binding]; other site 1048689007782 putative ATP binding site [chemical binding]; other site 1048689007783 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 1048689007784 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1048689007785 active site 1048689007786 phosphorylation site [posttranslational modification] 1048689007787 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1048689007788 dimerization domain swap beta strand [polypeptide binding]; other site 1048689007789 regulatory protein interface [polypeptide binding]; other site 1048689007790 active site 1048689007791 regulatory phosphorylation site [posttranslational modification]; other site 1048689007792 sugar efflux transporter B; Provisional; Region: PRK15011 1048689007793 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689007794 putative substrate translocation pore; other site 1048689007795 Flagellin N-methylase; Region: FliB; pfam03692 1048689007796 elongation factor P; Provisional; Region: PRK04542 1048689007797 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1048689007798 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1048689007799 RNA binding site [nucleotide binding]; other site 1048689007800 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1048689007801 RNA binding site [nucleotide binding]; other site 1048689007802 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1048689007803 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1048689007804 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1048689007805 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1048689007806 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1048689007807 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1048689007808 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1048689007809 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1048689007810 active site 1048689007811 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 1048689007812 NlpC/P60 family; Region: NLPC_P60; pfam00877 1048689007813 phage resistance protein; Provisional; Region: PRK10551 1048689007814 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1048689007815 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1048689007816 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1048689007817 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1048689007818 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 1048689007819 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048689007820 dimer interface [polypeptide binding]; other site 1048689007821 conserved gate region; other site 1048689007822 putative PBP binding loops; other site 1048689007823 ABC-ATPase subunit interface; other site 1048689007824 microcin C ABC transporter permease; Provisional; Region: PRK15021 1048689007825 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048689007826 dimer interface [polypeptide binding]; other site 1048689007827 conserved gate region; other site 1048689007828 ABC-ATPase subunit interface; other site 1048689007829 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 1048689007830 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1048689007831 Walker A/P-loop; other site 1048689007832 ATP binding site [chemical binding]; other site 1048689007833 Q-loop/lid; other site 1048689007834 ABC transporter signature motif; other site 1048689007835 Walker B; other site 1048689007836 D-loop; other site 1048689007837 H-loop/switch region; other site 1048689007838 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1048689007839 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1048689007840 Walker A/P-loop; other site 1048689007841 ATP binding site [chemical binding]; other site 1048689007842 Q-loop/lid; other site 1048689007843 ABC transporter signature motif; other site 1048689007844 Walker B; other site 1048689007845 D-loop; other site 1048689007846 H-loop/switch region; other site 1048689007847 hypothetical protein; Provisional; Region: PRK11835 1048689007848 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689007849 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 1048689007850 putative substrate translocation pore; other site 1048689007851 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 1048689007852 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1048689007853 RNA binding surface [nucleotide binding]; other site 1048689007854 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1048689007855 active site 1048689007856 uracil binding [chemical binding]; other site 1048689007857 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1048689007858 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1048689007859 ATP binding site [chemical binding]; other site 1048689007860 putative Mg++ binding site [ion binding]; other site 1048689007861 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1048689007862 nucleotide binding region [chemical binding]; other site 1048689007863 ATP-binding site [chemical binding]; other site 1048689007864 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 1048689007865 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1048689007866 5S rRNA interface [nucleotide binding]; other site 1048689007867 CTC domain interface [polypeptide binding]; other site 1048689007868 L16 interface [polypeptide binding]; other site 1048689007869 Nucleoid-associated protein [General function prediction only]; Region: COG3081 1048689007870 nucleoid-associated protein NdpA; Validated; Region: PRK00378 1048689007871 hypothetical protein; Provisional; Region: PRK13689 1048689007872 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 1048689007873 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 1048689007874 Sulfatase; Region: Sulfatase; pfam00884 1048689007875 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 1048689007876 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 1048689007877 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1048689007878 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1048689007879 transcriptional regulator NarP; Provisional; Region: PRK10403 1048689007880 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1048689007881 active site 1048689007882 phosphorylation site [posttranslational modification] 1048689007883 intermolecular recognition site; other site 1048689007884 dimerization interface [polypeptide binding]; other site 1048689007885 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1048689007886 DNA binding residues [nucleotide binding] 1048689007887 dimerization interface [polypeptide binding]; other site 1048689007888 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 1048689007889 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 1048689007890 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1048689007891 binding surface 1048689007892 TPR motif; other site 1048689007893 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 1048689007894 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 1048689007895 catalytic residues [active] 1048689007896 central insert; other site 1048689007897 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 1048689007898 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 1048689007899 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 1048689007900 heme exporter protein CcmC; Region: ccmC; TIGR01191 1048689007901 heme exporter protein CcmB; Region: ccmB; TIGR01190 1048689007902 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 1048689007903 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 1048689007904 Walker A/P-loop; other site 1048689007905 ATP binding site [chemical binding]; other site 1048689007906 Q-loop/lid; other site 1048689007907 ABC transporter signature motif; other site 1048689007908 Walker B; other site 1048689007909 D-loop; other site 1048689007910 H-loop/switch region; other site 1048689007911 cytochrome c-type protein NapC; Provisional; Region: PRK10617 1048689007912 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 1048689007913 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 1048689007914 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 1048689007915 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1048689007916 4Fe-4S binding domain; Region: Fer4; cl02805 1048689007917 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 1048689007918 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 1048689007919 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1048689007920 [4Fe-4S] binding site [ion binding]; other site 1048689007921 molybdopterin cofactor binding site; other site 1048689007922 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1048689007923 molybdopterin cofactor binding site; other site 1048689007924 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 1048689007925 ferredoxin-type protein; Provisional; Region: PRK10194 1048689007926 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 1048689007927 secondary substrate binding site; other site 1048689007928 primary substrate binding site; other site 1048689007929 inhibition loop; other site 1048689007930 dimerization interface [polypeptide binding]; other site 1048689007931 malate:quinone oxidoreductase; Validated; Region: PRK05257 1048689007932 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1048689007933 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 1048689007934 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1048689007935 Walker A/P-loop; other site 1048689007936 ATP binding site [chemical binding]; other site 1048689007937 Q-loop/lid; other site 1048689007938 ABC transporter signature motif; other site 1048689007939 Walker B; other site 1048689007940 D-loop; other site 1048689007941 H-loop/switch region; other site 1048689007942 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 1048689007943 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 1048689007944 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1048689007945 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1048689007946 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1048689007947 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1048689007948 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1048689007949 DNA binding site [nucleotide binding] 1048689007950 active site 1048689007951 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 1048689007952 ApbE family; Region: ApbE; pfam02424 1048689007953 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1048689007954 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1048689007955 trimer interface [polypeptide binding]; other site 1048689007956 eyelet of channel; other site 1048689007957 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 1048689007958 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1048689007959 ATP binding site [chemical binding]; other site 1048689007960 G-X-G motif; other site 1048689007961 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1048689007962 putative binding surface; other site 1048689007963 active site 1048689007964 transcriptional regulator RcsB; Provisional; Region: PRK10840 1048689007965 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1048689007966 active site 1048689007967 phosphorylation site [posttranslational modification] 1048689007968 intermolecular recognition site; other site 1048689007969 dimerization interface [polypeptide binding]; other site 1048689007970 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1048689007971 DNA binding residues [nucleotide binding] 1048689007972 dimerization interface [polypeptide binding]; other site 1048689007973 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 1048689007974 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1048689007975 dimer interface [polypeptide binding]; other site 1048689007976 phosphorylation site [posttranslational modification] 1048689007977 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1048689007978 ATP binding site [chemical binding]; other site 1048689007979 Mg2+ binding site [ion binding]; other site 1048689007980 G-X-G motif; other site 1048689007981 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 1048689007982 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1048689007983 active site 1048689007984 phosphorylation site [posttranslational modification] 1048689007985 intermolecular recognition site; other site 1048689007986 dimerization interface [polypeptide binding]; other site 1048689007987 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 1048689007988 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 1048689007989 Predicted secreted protein [Function unknown]; Region: COG5445 1048689007990 Stage II sporulation protein; Region: SpoIID; pfam08486 1048689007991 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 1048689007992 Predicted secreted protein [Function unknown]; Region: COG5445 1048689007993 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 1048689007994 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 1048689007995 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1048689007996 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1048689007997 potential frameshift: common BLAST hit: gi|209398434|ref|YP_002271634.1| alpha-2-macroglobulin family protein 1048689007998 MG2 domain; Region: A2M_N; pfam01835 1048689007999 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 1048689008000 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 1048689008001 Alpha-2-macroglobulin family; Region: A2M; pfam00207 1048689008002 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 1048689008003 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3234 1048689008004 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4685 1048689008005 DNA gyrase subunit A; Validated; Region: PRK05560 1048689008006 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1048689008007 CAP-like domain; other site 1048689008008 active site 1048689008009 primary dimer interface [polypeptide binding]; other site 1048689008010 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1048689008011 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1048689008012 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1048689008013 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1048689008014 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1048689008015 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1048689008016 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 1048689008017 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1048689008018 S-adenosylmethionine binding site [chemical binding]; other site 1048689008019 adhesin; Provisional; Region: PRK09752 1048689008020 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 1048689008021 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1048689008022 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 1048689008023 ATP cone domain; Region: ATP-cone; pfam03477 1048689008024 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1048689008025 active site 1048689008026 dimer interface [polypeptide binding]; other site 1048689008027 catalytic residues [active] 1048689008028 effector binding site; other site 1048689008029 R2 peptide binding site; other site 1048689008030 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1048689008031 dimer interface [polypeptide binding]; other site 1048689008032 putative radical transfer pathway; other site 1048689008033 diiron center [ion binding]; other site 1048689008034 tyrosyl radical; other site 1048689008035 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1048689008036 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1048689008037 catalytic loop [active] 1048689008038 iron binding site [ion binding]; other site 1048689008039 hypothetical protein; Provisional; Region: PRK09902 1048689008040 potential frameshift: common BLAST hit: gi|254794129|ref|YP_003078966.1| putative antibiotic efflux protein 1048689008041 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1048689008042 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1048689008043 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1048689008044 dimerization interface [polypeptide binding]; other site 1048689008045 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 1048689008046 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 1048689008047 active site 1048689008048 catalytic site [active] 1048689008049 metal binding site [ion binding]; metal-binding site 1048689008050 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 1048689008051 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689008052 putative substrate translocation pore; other site 1048689008053 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 1048689008054 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1048689008055 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1048689008056 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 1048689008057 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 1048689008058 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 1048689008059 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1048689008060 Cysteine-rich domain; Region: CCG; pfam02754 1048689008061 Cysteine-rich domain; Region: CCG; pfam02754 1048689008062 hypothetical protein; Provisional; Region: PRK09956 1048689008063 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1048689008064 2-keto-3-deoxy-L-rhamnonate aldolase; Provisional; Region: PRK10128 1048689008065 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1048689008066 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689008067 putative substrate translocation pore; other site 1048689008068 L-rhamnonate dehydratase; Provisional; Region: PRK15440 1048689008069 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 1048689008070 putative active site pocket [active] 1048689008071 putative metal binding site [ion binding]; other site 1048689008072 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1048689008073 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1048689008074 Bacterial transcriptional regulator; Region: IclR; pfam01614 1048689008075 hypothetical protein; Provisional; Region: PRK03673 1048689008076 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1048689008077 putative MPT binding site; other site 1048689008078 Competence-damaged protein; Region: CinA; cl00666 1048689008079 YfaZ precursor; Region: YfaZ; pfam07437 1048689008080 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 1048689008081 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 1048689008082 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1048689008083 catalytic core [active] 1048689008084 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1048689008085 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1048689008086 inhibitor-cofactor binding pocket; inhibition site 1048689008087 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048689008088 catalytic residue [active] 1048689008089 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1048689008090 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1048689008091 Ligand binding site; other site 1048689008092 Putative Catalytic site; other site 1048689008093 DXD motif; other site 1048689008094 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 1048689008095 ArnA, N-terminal formyltransferase domain; Region: FMT_core_ArnA_N; cd08644 1048689008096 substrate binding site [chemical binding]; other site 1048689008097 cosubstrate binding site; other site 1048689008098 catalytic site [active] 1048689008099 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 1048689008100 active site 1048689008101 hexamer interface [polypeptide binding]; other site 1048689008102 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 1048689008103 NAD binding site [chemical binding]; other site 1048689008104 substrate binding site [chemical binding]; other site 1048689008105 active site 1048689008106 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 1048689008107 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 1048689008108 putative active site [active] 1048689008109 putative catalytic site [active] 1048689008110 putative Zn binding site [ion binding]; other site 1048689008111 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 1048689008112 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1048689008113 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 1048689008114 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 1048689008115 signal transduction protein PmrD; Provisional; Region: PRK15450 1048689008116 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 1048689008117 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1048689008118 acyl-activating enzyme (AAE) consensus motif; other site 1048689008119 putative AMP binding site [chemical binding]; other site 1048689008120 putative active site [active] 1048689008121 putative CoA binding site [chemical binding]; other site 1048689008122 O-succinylbenzoate synthase; Provisional; Region: PRK05105 1048689008123 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1048689008124 active site 1048689008125 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1048689008126 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1048689008127 substrate binding site [chemical binding]; other site 1048689008128 oxyanion hole (OAH) forming residues; other site 1048689008129 trimer interface [polypeptide binding]; other site 1048689008130 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 1048689008131 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1048689008132 nucleophilic elbow; other site 1048689008133 catalytic triad; other site 1048689008134 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1048689008135 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1048689008136 dimer interface [polypeptide binding]; other site 1048689008137 tetramer interface [polypeptide binding]; other site 1048689008138 PYR/PP interface [polypeptide binding]; other site 1048689008139 TPP binding site [chemical binding]; other site 1048689008140 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1048689008141 TPP-binding site; other site 1048689008142 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 1048689008143 isochorismate synthases; Region: isochor_syn; TIGR00543 1048689008144 hypothetical protein; Provisional; Region: PRK10404 1048689008145 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1048689008146 Coenzyme A binding pocket [chemical binding]; other site 1048689008147 ribonuclease BN; Region: true_RNase_BN; TIGR02649 1048689008148 potential frameshift: common BLAST hit: gi|254794165|ref|YP_003079002.1| deubiquitinase 1048689008149 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1048689008150 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 1048689008151 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1048689008152 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1048689008153 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1048689008154 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1048689008155 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1048689008156 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1048689008157 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1048689008158 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1048689008159 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1048689008160 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1048689008161 4Fe-4S binding domain; Region: Fer4; pfam00037 1048689008162 4Fe-4S binding domain; Region: Fer4; pfam00037 1048689008163 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1048689008164 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 1048689008165 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1048689008166 catalytic loop [active] 1048689008167 iron binding site [ion binding]; other site 1048689008168 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1048689008169 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 1048689008170 [4Fe-4S] binding site [ion binding]; other site 1048689008171 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 1048689008172 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 1048689008173 SLBB domain; Region: SLBB; pfam10531 1048689008174 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 1048689008175 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1048689008176 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1048689008177 putative dimer interface [polypeptide binding]; other site 1048689008178 [2Fe-2S] cluster binding site [ion binding]; other site 1048689008179 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 1048689008180 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1048689008181 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1048689008182 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 1048689008183 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 1048689008184 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 1048689008185 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1048689008186 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 1048689008187 putative dimerization interface [polypeptide binding]; other site 1048689008188 aminotransferase AlaT; Validated; Region: PRK09265 1048689008189 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1048689008190 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048689008191 homodimer interface [polypeptide binding]; other site 1048689008192 catalytic residue [active] 1048689008193 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1048689008194 Zn2+ binding site [ion binding]; other site 1048689008195 Mg2+ binding site [ion binding]; other site 1048689008196 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1048689008197 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1048689008198 TrkA-C domain; Region: TrkA_C; pfam02080 1048689008199 TrkA-C domain; Region: TrkA_C; pfam02080 1048689008200 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1048689008201 putative phosphatase; Provisional; Region: PRK11587 1048689008202 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1048689008203 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1048689008204 motif II; other site 1048689008205 hypothetical protein; Validated; Region: PRK05445 1048689008206 hypothetical protein; Provisional; Region: PRK01816 1048689008207 propionate/acetate kinase; Provisional; Region: PRK12379 1048689008208 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1048689008209 phosphate acetyltransferase; Reviewed; Region: PRK05632 1048689008210 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1048689008211 DRTGG domain; Region: DRTGG; pfam07085 1048689008212 phosphate acetyltransferase; Region: pta; TIGR00651 1048689008213 hypothetical protein; Provisional; Region: PRK11588 1048689008214 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1048689008215 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 1048689008216 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 1048689008217 nudix motif; other site 1048689008218 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1048689008219 active site 1048689008220 metal binding site [ion binding]; metal-binding site 1048689008221 homotetramer interface [polypeptide binding]; other site 1048689008222 glutathione S-transferase; Provisional; Region: PRK15113 1048689008223 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1048689008224 C-terminal domain interface [polypeptide binding]; other site 1048689008225 GSH binding site (G-site) [chemical binding]; other site 1048689008226 dimer interface [polypeptide binding]; other site 1048689008227 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 1048689008228 N-terminal domain interface [polypeptide binding]; other site 1048689008229 putative dimer interface [polypeptide binding]; other site 1048689008230 putative substrate binding pocket (H-site) [chemical binding]; other site 1048689008231 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 1048689008232 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1048689008233 C-terminal domain interface [polypeptide binding]; other site 1048689008234 GSH binding site (G-site) [chemical binding]; other site 1048689008235 dimer interface [polypeptide binding]; other site 1048689008236 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 1048689008237 N-terminal domain interface [polypeptide binding]; other site 1048689008238 putative dimer interface [polypeptide binding]; other site 1048689008239 active site 1048689008240 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1048689008241 homooctamer interface [polypeptide binding]; other site 1048689008242 active site 1048689008243 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1048689008244 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1048689008245 putative NAD(P) binding site [chemical binding]; other site 1048689008246 putative active site [active] 1048689008247 putative transposase; Provisional; Region: PRK09857 1048689008248 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1048689008249 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 1048689008250 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1048689008251 Walker A/P-loop; other site 1048689008252 ATP binding site [chemical binding]; other site 1048689008253 Q-loop/lid; other site 1048689008254 ABC transporter signature motif; other site 1048689008255 Walker B; other site 1048689008256 D-loop; other site 1048689008257 H-loop/switch region; other site 1048689008258 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048689008259 dimer interface [polypeptide binding]; other site 1048689008260 conserved gate region; other site 1048689008261 putative PBP binding loops; other site 1048689008262 ABC-ATPase subunit interface; other site 1048689008263 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1048689008264 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048689008265 dimer interface [polypeptide binding]; other site 1048689008266 conserved gate region; other site 1048689008267 putative PBP binding loops; other site 1048689008268 ABC-ATPase subunit interface; other site 1048689008269 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 1048689008270 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1048689008271 substrate binding pocket [chemical binding]; other site 1048689008272 membrane-bound complex binding site; other site 1048689008273 hinge residues; other site 1048689008274 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 1048689008275 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1048689008276 substrate binding pocket [chemical binding]; other site 1048689008277 membrane-bound complex binding site; other site 1048689008278 hinge residues; other site 1048689008279 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 1048689008280 Flavoprotein; Region: Flavoprotein; pfam02441 1048689008281 amidophosphoribosyltransferase; Provisional; Region: PRK09246 1048689008282 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1048689008283 active site 1048689008284 tetramer interface [polypeptide binding]; other site 1048689008285 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1048689008286 active site 1048689008287 colicin V production protein; Provisional; Region: PRK10845 1048689008288 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1048689008289 cell division protein DedD; Provisional; Region: PRK11633 1048689008290 Sporulation related domain; Region: SPOR; pfam05036 1048689008291 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 1048689008292 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1048689008293 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1048689008294 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1048689008295 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1048689008296 hypothetical protein; Provisional; Region: PRK10847 1048689008297 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1048689008298 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1048689008299 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1048689008300 dimerization interface 3.5A [polypeptide binding]; other site 1048689008301 active site 1048689008302 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 1048689008303 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1048689008304 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 1048689008305 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 1048689008306 ligand binding site [chemical binding]; other site 1048689008307 NAD binding site [chemical binding]; other site 1048689008308 catalytic site [active] 1048689008309 homodimer interface [polypeptide binding]; other site 1048689008310 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 1048689008311 putative transporter; Provisional; Region: PRK12382 1048689008312 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689008313 putative substrate translocation pore; other site 1048689008314 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 1048689008315 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1048689008316 dimer interface [polypeptide binding]; other site 1048689008317 active site 1048689008318 Uncharacterized conserved protein [Function unknown]; Region: COG4121 1048689008319 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 1048689008320 YfcL protein; Region: YfcL; pfam08891 1048689008321 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 1048689008322 hypothetical protein; Provisional; Region: PRK10621 1048689008323 Predicted permeases [General function prediction only]; Region: COG0730 1048689008324 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 1048689008325 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 1048689008326 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1048689008327 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1048689008328 Tetramer interface [polypeptide binding]; other site 1048689008329 active site 1048689008330 FMN-binding site [chemical binding]; other site 1048689008331 HemK family putative methylases; Region: hemK_fam; TIGR00536 1048689008332 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1048689008333 S-adenosylmethionine binding site [chemical binding]; other site 1048689008334 hypothetical protein; Provisional; Region: PRK04946 1048689008335 Smr domain; Region: Smr; pfam01713 1048689008336 Protein of unknown function (DUF2544); Region: DUF2544; pfam11245 1048689008337 Fimbrial protein; Region: Fimbrial; cl01416 1048689008338 Fimbrial protein; Region: Fimbrial; cl01416 1048689008339 Fimbrial protein; Region: Fimbrial; cl01416 1048689008340 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1048689008341 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1048689008342 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 1048689008343 PapC N-terminal domain; Region: PapC_N; pfam13954 1048689008344 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1048689008345 PapC C-terminal domain; Region: PapC_C; pfam13953 1048689008346 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1048689008347 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1048689008348 catalytic core [active] 1048689008349 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 1048689008350 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1048689008351 substrate binding site [chemical binding]; other site 1048689008352 oxyanion hole (OAH) forming residues; other site 1048689008353 trimer interface [polypeptide binding]; other site 1048689008354 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1048689008355 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1048689008356 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 1048689008357 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1048689008358 dimer interface [polypeptide binding]; other site 1048689008359 active site 1048689008360 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 1048689008361 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 1048689008362 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 1048689008363 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 1048689008364 prophage Cp11 1048689008365 integrase; Provisional; Region: PRK09692 1048689008366 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1048689008367 active site 1048689008368 Int/Topo IB signature motif; other site 1048689008369 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1048689008370 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 1048689008371 Protein of unknown function (DUF2824); Region: DUF2824; cl10279 1048689008372 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1048689008373 Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient...; Region: SR_Res_par; cd03767 1048689008374 catalytic residues [active] 1048689008375 catalytic nucleophile [active] 1048689008376 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 1048689008377 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689008378 putative substrate translocation pore; other site 1048689008379 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1048689008380 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1048689008381 putative substrate binding site [chemical binding]; other site 1048689008382 putative ATP binding site [chemical binding]; other site 1048689008383 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1048689008384 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1048689008385 substrate binding [chemical binding]; other site 1048689008386 active site 1048689008387 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1048689008388 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1048689008389 DNA binding site [nucleotide binding] 1048689008390 domain linker motif; other site 1048689008391 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 1048689008392 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 1048689008393 putative dimerization interface [polypeptide binding]; other site 1048689008394 putative ligand binding site [chemical binding]; other site 1048689008395 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1048689008396 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1048689008397 potential frameshift: common BLAST hit: gi|254794328|ref|YP_003079165.1| D-serine dehydratase 1048689008398 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1048689008399 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689008400 putative substrate translocation pore; other site 1048689008401 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689008402 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1048689008403 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1048689008404 HlyD family secretion protein; Region: HlyD_3; pfam13437 1048689008405 DNA-binding transcriptional activator EvgA; Provisional; Region: PRK09958 1048689008406 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1048689008407 active site 1048689008408 phosphorylation site [posttranslational modification] 1048689008409 intermolecular recognition site; other site 1048689008410 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1048689008411 DNA binding residues [nucleotide binding] 1048689008412 dimerization interface [polypeptide binding]; other site 1048689008413 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 1048689008414 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1048689008415 substrate binding pocket [chemical binding]; other site 1048689008416 membrane-bound complex binding site; other site 1048689008417 hinge residues; other site 1048689008418 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1048689008419 substrate binding pocket [chemical binding]; other site 1048689008420 membrane-bound complex binding site; other site 1048689008421 hinge residues; other site 1048689008422 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1048689008423 dimer interface [polypeptide binding]; other site 1048689008424 phosphorylation site [posttranslational modification] 1048689008425 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1048689008426 ATP binding site [chemical binding]; other site 1048689008427 Mg2+ binding site [ion binding]; other site 1048689008428 G-X-G motif; other site 1048689008429 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1048689008430 active site 1048689008431 phosphorylation site [posttranslational modification] 1048689008432 intermolecular recognition site; other site 1048689008433 dimerization interface [polypeptide binding]; other site 1048689008434 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1048689008435 putative binding surface; other site 1048689008436 active site 1048689008437 putative CoA-transferase; Provisional; Region: PRK11430 1048689008438 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1048689008439 putative transporter YfdV; Provisional; Region: PRK09903 1048689008440 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 1048689008441 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1048689008442 PYR/PP interface [polypeptide binding]; other site 1048689008443 dimer interface [polypeptide binding]; other site 1048689008444 TPP binding site [chemical binding]; other site 1048689008445 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1048689008446 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 1048689008447 TPP-binding site; other site 1048689008448 dimer interface [polypeptide binding]; other site 1048689008449 formyl-coenzyme A transferase; Provisional; Region: PRK05398 1048689008450 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1048689008451 hypothetical protein; Provisional; Region: PRK10316 1048689008452 YfdX protein; Region: YfdX; pfam10938 1048689008453 Protein of unknown function (DUF2545); Region: DUF2545; pfam10810 1048689008454 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1048689008455 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1048689008456 putative acyl-acceptor binding pocket; other site 1048689008457 aminotransferase; Validated; Region: PRK08175 1048689008458 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1048689008459 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048689008460 homodimer interface [polypeptide binding]; other site 1048689008461 catalytic residue [active] 1048689008462 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1048689008463 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1048689008464 GAF domain; Region: GAF; pfam01590 1048689008465 Histidine kinase; Region: His_kinase; pfam06580 1048689008466 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1048689008467 ATP binding site [chemical binding]; other site 1048689008468 Mg2+ binding site [ion binding]; other site 1048689008469 G-X-G motif; other site 1048689008470 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1048689008471 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1048689008472 active site 1048689008473 phosphorylation site [posttranslational modification] 1048689008474 intermolecular recognition site; other site 1048689008475 dimerization interface [polypeptide binding]; other site 1048689008476 LytTr DNA-binding domain; Region: LytTR; pfam04397 1048689008477 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1048689008478 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1048689008479 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1048689008480 dimerization domain swap beta strand [polypeptide binding]; other site 1048689008481 regulatory protein interface [polypeptide binding]; other site 1048689008482 active site 1048689008483 regulatory phosphorylation site [posttranslational modification]; other site 1048689008484 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1048689008485 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1048689008486 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1048689008487 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1048689008488 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1048689008489 active site 1048689008490 phosphorylation site [posttranslational modification] 1048689008491 exoaminopeptidase; Provisional; Region: PRK09961 1048689008492 M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638 1048689008493 oligomer interface [polypeptide binding]; other site 1048689008494 active site 1048689008495 metal binding site [ion binding]; metal-binding site 1048689008496 aminopeptidase; Provisional; Region: PRK09795 1048689008497 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1048689008498 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1048689008499 active site 1048689008500 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1048689008501 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1048689008502 active site 1048689008503 P-loop; other site 1048689008504 phosphorylation site [posttranslational modification] 1048689008505 glucokinase, proteobacterial type; Region: glk; TIGR00749 1048689008506 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1048689008507 nucleotide binding site [chemical binding]; other site 1048689008508 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1048689008509 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1048689008510 Cl- selectivity filter; other site 1048689008511 Cl- binding residues [ion binding]; other site 1048689008512 pore gating glutamate residue; other site 1048689008513 dimer interface [polypeptide binding]; other site 1048689008514 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 1048689008515 manganese transport protein MntH; Reviewed; Region: PRK00701 1048689008516 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1048689008517 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1048689008518 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1048689008519 Nucleoside recognition; Region: Gate; pfam07670 1048689008520 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1048689008521 MASE1; Region: MASE1; pfam05231 1048689008522 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1048689008523 diguanylate cyclase; Region: GGDEF; smart00267 1048689008524 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1048689008525 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 1048689008526 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1048689008527 salt bridge; other site 1048689008528 non-specific DNA binding site [nucleotide binding]; other site 1048689008529 sequence-specific DNA binding site [nucleotide binding]; other site 1048689008530 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1048689008531 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1048689008532 Probable transposase; Region: OrfB_IS605; pfam01385 1048689008533 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1048689008534 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1048689008535 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1048689008536 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1048689008537 active site 1048689008538 HIGH motif; other site 1048689008539 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1048689008540 active site 1048689008541 KMSKS motif; other site 1048689008542 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1048689008543 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1048689008544 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1048689008545 putative dimerization interface [polypeptide binding]; other site 1048689008546 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1048689008547 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 1048689008548 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 1048689008549 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1048689008550 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1048689008551 nucleotide binding pocket [chemical binding]; other site 1048689008552 K-X-D-G motif; other site 1048689008553 catalytic site [active] 1048689008554 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1048689008555 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1048689008556 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1048689008557 Dimer interface [polypeptide binding]; other site 1048689008558 BRCT sequence motif; other site 1048689008559 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 1048689008560 cell division protein ZipA; Provisional; Region: PRK03427 1048689008561 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 1048689008562 FtsZ protein binding site [polypeptide binding]; other site 1048689008563 putative sulfate transport protein CysZ; Validated; Region: PRK04949 1048689008564 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1048689008565 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1048689008566 dimer interface [polypeptide binding]; other site 1048689008567 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048689008568 catalytic residue [active] 1048689008569 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1048689008570 dimerization domain swap beta strand [polypeptide binding]; other site 1048689008571 regulatory protein interface [polypeptide binding]; other site 1048689008572 active site 1048689008573 regulatory phosphorylation site [posttranslational modification]; other site 1048689008574 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 1048689008575 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1048689008576 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1048689008577 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1048689008578 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1048689008579 HPr interaction site; other site 1048689008580 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1048689008581 active site 1048689008582 phosphorylation site [posttranslational modification] 1048689008583 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1048689008584 dimer interface [polypeptide binding]; other site 1048689008585 pyridoxamine kinase; Validated; Region: PRK05756 1048689008586 pyridoxal binding site [chemical binding]; other site 1048689008587 ATP binding site [chemical binding]; other site 1048689008588 hypothetical protein; Provisional; Region: PRK10318 1048689008589 cysteine synthase B; Region: cysM; TIGR01138 1048689008590 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1048689008591 dimer interface [polypeptide binding]; other site 1048689008592 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048689008593 catalytic residue [active] 1048689008594 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 1048689008595 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1048689008596 Walker A/P-loop; other site 1048689008597 ATP binding site [chemical binding]; other site 1048689008598 Q-loop/lid; other site 1048689008599 ABC transporter signature motif; other site 1048689008600 Walker B; other site 1048689008601 D-loop; other site 1048689008602 H-loop/switch region; other site 1048689008603 TOBE-like domain; Region: TOBE_3; pfam12857 1048689008604 sulfate transport protein; Provisional; Region: cysT; CHL00187 1048689008605 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048689008606 dimer interface [polypeptide binding]; other site 1048689008607 conserved gate region; other site 1048689008608 putative PBP binding loops; other site 1048689008609 ABC-ATPase subunit interface; other site 1048689008610 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1048689008611 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048689008612 dimer interface [polypeptide binding]; other site 1048689008613 conserved gate region; other site 1048689008614 putative PBP binding loops; other site 1048689008615 ABC-ATPase subunit interface; other site 1048689008616 thiosulfate transporter subunit; Provisional; Region: PRK10852 1048689008617 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1048689008618 short chain dehydrogenase; Provisional; Region: PRK08226 1048689008619 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 1048689008620 NAD binding site [chemical binding]; other site 1048689008621 homotetramer interface [polypeptide binding]; other site 1048689008622 homodimer interface [polypeptide binding]; other site 1048689008623 active site 1048689008624 transcriptional regulator MurR; Provisional; Region: PRK15482 1048689008625 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1048689008626 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1048689008627 putative active site [active] 1048689008628 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1048689008629 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1048689008630 putative active site [active] 1048689008631 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 1048689008632 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1048689008633 active site turn [active] 1048689008634 phosphorylation site [posttranslational modification] 1048689008635 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1048689008636 putative periplasmic esterase; Provisional; Region: PRK03642 1048689008637 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1048689008638 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 1048689008639 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 1048689008640 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 1048689008641 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 1048689008642 putative acetyltransferase; Provisional; Region: PRK03624 1048689008643 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1048689008644 Coenzyme A binding pocket [chemical binding]; other site 1048689008645 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 1048689008646 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1048689008647 active site 1048689008648 metal binding site [ion binding]; metal-binding site 1048689008649 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 1048689008650 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 1048689008651 transcriptional regulator EutR; Provisional; Region: PRK10130 1048689008652 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1048689008653 carboxysome structural protein EutK; Provisional; Region: PRK15466 1048689008654 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 1048689008655 Hexamer interface [polypeptide binding]; other site 1048689008656 Hexagonal pore residue; other site 1048689008657 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 1048689008658 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 1048689008659 putative hexamer interface [polypeptide binding]; other site 1048689008660 putative hexagonal pore; other site 1048689008661 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 1048689008662 putative hexamer interface [polypeptide binding]; other site 1048689008663 putative hexagonal pore; other site 1048689008664 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 1048689008665 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 1048689008666 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 1048689008667 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 1048689008668 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 1048689008669 ethanol dehydrogenase EutG; Provisional; Region: PRK15454 1048689008670 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 1048689008671 active site 1048689008672 metal binding site [ion binding]; metal-binding site 1048689008673 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 1048689008674 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1048689008675 nucleotide binding site [chemical binding]; other site 1048689008676 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 1048689008677 putative catalytic cysteine [active] 1048689008678 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 1048689008679 Hexamer/Pentamer interface [polypeptide binding]; other site 1048689008680 central pore; other site 1048689008681 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1048689008682 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 1048689008683 Hexamer interface [polypeptide binding]; other site 1048689008684 Putative hexagonal pore residue; other site 1048689008685 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1048689008686 ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020 1048689008687 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 1048689008688 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766 1048689008689 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1048689008690 G1 box; other site 1048689008691 GTP/Mg2+ binding site [chemical binding]; other site 1048689008692 G2 box; other site 1048689008693 Switch I region; other site 1048689008694 G3 box; other site 1048689008695 Switch II region; other site 1048689008696 G4 box; other site 1048689008697 G5 box; other site 1048689008698 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 1048689008699 putative hexamer interface [polypeptide binding]; other site 1048689008700 putative hexagonal pore; other site 1048689008701 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 1048689008702 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1048689008703 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1048689008704 putative NAD(P) binding site [chemical binding]; other site 1048689008705 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 1048689008706 transaldolase-like protein; Provisional; Region: PTZ00411 1048689008707 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1048689008708 active site 1048689008709 dimer interface [polypeptide binding]; other site 1048689008710 catalytic residue [active] 1048689008711 transketolase; Reviewed; Region: PRK12753 1048689008712 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1048689008713 TPP-binding site [chemical binding]; other site 1048689008714 dimer interface [polypeptide binding]; other site 1048689008715 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1048689008716 PYR/PP interface [polypeptide binding]; other site 1048689008717 dimer interface [polypeptide binding]; other site 1048689008718 TPP binding site [chemical binding]; other site 1048689008719 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1048689008720 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 1048689008721 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 1048689008722 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1048689008723 dimer interface [polypeptide binding]; other site 1048689008724 ADP-ribose binding site [chemical binding]; other site 1048689008725 active site 1048689008726 nudix motif; other site 1048689008727 metal binding site [ion binding]; metal-binding site 1048689008728 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 1048689008729 4Fe-4S binding domain; Region: Fer4; pfam00037 1048689008730 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1048689008731 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1048689008732 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 1048689008733 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1048689008734 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1048689008735 dimerization interface [polypeptide binding]; other site 1048689008736 Histidine kinase; Region: HisKA_3; pfam07730 1048689008737 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1048689008738 ATP binding site [chemical binding]; other site 1048689008739 Mg2+ binding site [ion binding]; other site 1048689008740 G-X-G motif; other site 1048689008741 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 1048689008742 Protein export membrane protein; Region: SecD_SecF; cl14618 1048689008743 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 1048689008744 ArsC family; Region: ArsC; pfam03960 1048689008745 putative catalytic residues [active] 1048689008746 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 1048689008747 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 1048689008748 metal binding site [ion binding]; metal-binding site 1048689008749 dimer interface [polypeptide binding]; other site 1048689008750 hypothetical protein; Provisional; Region: PRK13664 1048689008751 putative hydrolase; Provisional; Region: PRK11460 1048689008752 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 1048689008753 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 1048689008754 Helicase; Region: Helicase_RecD; pfam05127 1048689008755 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 1048689008756 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 1048689008757 Predicted metalloprotease [General function prediction only]; Region: COG2321 1048689008758 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1048689008759 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1048689008760 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1048689008761 ATP binding site [chemical binding]; other site 1048689008762 active site 1048689008763 substrate binding site [chemical binding]; other site 1048689008764 lipoprotein; Provisional; Region: PRK11679 1048689008765 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 1048689008766 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1048689008767 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1048689008768 dimer interface [polypeptide binding]; other site 1048689008769 active site 1048689008770 catalytic residue [active] 1048689008771 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 1048689008772 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 1048689008773 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1048689008774 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1048689008775 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1048689008776 catalytic triad [active] 1048689008777 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 1048689008778 4Fe-4S binding domain; Region: Fer4; pfam00037 1048689008779 hydrogenase 4 subunit B; Validated; Region: PRK06521 1048689008780 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1048689008781 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1048689008782 NADH dehydrogenase; Region: NADHdh; cl00469 1048689008783 hydrogenase 4 subunit D; Validated; Region: PRK06525 1048689008784 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1048689008785 hydrogenase 4 membrane subunit; Provisional; Region: hyfE; PRK11492 1048689008786 hydrogenase 4 subunit F; Validated; Region: PRK06458 1048689008787 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1048689008788 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 1048689008789 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 1048689008790 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1048689008791 hydrogenase 4 subunit H; Validated; Region: PRK08222 1048689008792 4Fe-4S binding domain; Region: Fer4; pfam00037 1048689008793 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 1048689008794 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 1048689008795 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 1048689008796 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1048689008797 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1048689008798 Walker A motif; other site 1048689008799 ATP binding site [chemical binding]; other site 1048689008800 Walker B motif; other site 1048689008801 arginine finger; other site 1048689008802 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1048689008803 putative formate transporter; Provisional; Region: focB; PRK09713 1048689008804 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1048689008805 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1048689008806 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 1048689008807 Peptidase family M48; Region: Peptidase_M48; cl12018 1048689008808 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1048689008809 ArsC family; Region: ArsC; pfam03960 1048689008810 catalytic residues [active] 1048689008811 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 1048689008812 DNA replication initiation factor; Provisional; Region: PRK08084 1048689008813 uracil transporter; Provisional; Region: PRK10720 1048689008814 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1048689008815 active site 1048689008816 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1048689008817 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1048689008818 dimerization interface [polypeptide binding]; other site 1048689008819 putative ATP binding site [chemical binding]; other site 1048689008820 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1048689008821 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1048689008822 active site 1048689008823 substrate binding site [chemical binding]; other site 1048689008824 cosubstrate binding site; other site 1048689008825 catalytic site [active] 1048689008826 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 1048689008827 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1048689008828 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1048689008829 Catalytic C-terminal domain, first repeat, of prokaryotic polyphosphate kinase 1 and similar proteins; Region: PLDc_PPK1_C1; cd09114 1048689008830 domain interface [polypeptide binding]; other site 1048689008831 active site 1048689008832 catalytic site [active] 1048689008833 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1048689008834 putative active site [active] 1048689008835 catalytic site [active] 1048689008836 exopolyphosphatase; Provisional; Region: PRK10854 1048689008837 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1048689008838 MASE1; Region: MASE1; pfam05231 1048689008839 diguanylate cyclase; Region: GGDEF; smart00267 1048689008840 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1048689008841 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1048689008842 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 1048689008843 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 1048689008844 GMP synthase; Reviewed; Region: guaA; PRK00074 1048689008845 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1048689008846 AMP/PPi binding site [chemical binding]; other site 1048689008847 candidate oxyanion hole; other site 1048689008848 catalytic triad [active] 1048689008849 potential glutamine specificity residues [chemical binding]; other site 1048689008850 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1048689008851 ATP Binding subdomain [chemical binding]; other site 1048689008852 Ligand Binding sites [chemical binding]; other site 1048689008853 Dimerization subdomain; other site 1048689008854 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1048689008855 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1048689008856 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1048689008857 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1048689008858 active site 1048689008859 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 1048689008860 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1048689008861 generic binding surface II; other site 1048689008862 generic binding surface I; other site 1048689008863 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 1048689008864 GTP-binding protein Der; Reviewed; Region: PRK00093 1048689008865 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1048689008866 G1 box; other site 1048689008867 GTP/Mg2+ binding site [chemical binding]; other site 1048689008868 Switch I region; other site 1048689008869 G2 box; other site 1048689008870 Switch II region; other site 1048689008871 G3 box; other site 1048689008872 G4 box; other site 1048689008873 G5 box; other site 1048689008874 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1048689008875 G1 box; other site 1048689008876 GTP/Mg2+ binding site [chemical binding]; other site 1048689008877 Switch I region; other site 1048689008878 G2 box; other site 1048689008879 G3 box; other site 1048689008880 Switch II region; other site 1048689008881 G4 box; other site 1048689008882 G5 box; other site 1048689008883 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 1048689008884 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cd00216 1048689008885 Trp docking motif [polypeptide binding]; other site 1048689008886 active site 1048689008887 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 1048689008888 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1048689008889 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1048689008890 dimer interface [polypeptide binding]; other site 1048689008891 motif 1; other site 1048689008892 active site 1048689008893 motif 2; other site 1048689008894 motif 3; other site 1048689008895 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1048689008896 anticodon binding site; other site 1048689008897 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1048689008898 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1048689008899 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1048689008900 cytoskeletal protein RodZ; Provisional; Region: PRK10856 1048689008901 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1048689008902 non-specific DNA binding site [nucleotide binding]; other site 1048689008903 salt bridge; other site 1048689008904 sequence-specific DNA binding site [nucleotide binding]; other site 1048689008905 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1048689008906 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 1048689008907 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1048689008908 FeS/SAM binding site; other site 1048689008909 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1048689008910 active site 1048689008911 multimer interface [polypeptide binding]; other site 1048689008912 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 1048689008913 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1048689008914 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 1048689008915 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1048689008916 4Fe-4S binding domain; Region: Fer4; pfam00037 1048689008917 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 1048689008918 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1048689008919 putative [Fe4-S4] binding site [ion binding]; other site 1048689008920 putative molybdopterin cofactor binding site [chemical binding]; other site 1048689008921 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1048689008922 putative molybdopterin cofactor binding site; other site 1048689008923 penicillin-binding protein 1C; Provisional; Region: PRK11240 1048689008924 Transglycosylase; Region: Transgly; pfam00912 1048689008925 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1048689008926 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 1048689008927 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 1048689008928 MG2 domain; Region: A2M_N; pfam01835 1048689008929 Alpha-2-macroglobulin family; Region: A2M; pfam00207 1048689008930 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 1048689008931 surface patch; other site 1048689008932 thioester region; other site 1048689008933 specificity defining residues; other site 1048689008934 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 1048689008935 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1048689008936 active site residue [active] 1048689008937 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1048689008938 active site residue [active] 1048689008939 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 1048689008940 aminopeptidase B; Provisional; Region: PRK05015 1048689008941 Peptidase; Region: DUF3663; pfam12404 1048689008942 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1048689008943 interface (dimer of trimers) [polypeptide binding]; other site 1048689008944 Substrate-binding/catalytic site; other site 1048689008945 Zn-binding sites [ion binding]; other site 1048689008946 hypothetical protein; Provisional; Region: PRK10721 1048689008947 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1048689008948 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1048689008949 catalytic loop [active] 1048689008950 iron binding site [ion binding]; other site 1048689008951 chaperone protein HscA; Provisional; Region: hscA; PRK05183 1048689008952 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 1048689008953 nucleotide binding site [chemical binding]; other site 1048689008954 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1048689008955 SBD interface [polypeptide binding]; other site 1048689008956 co-chaperone HscB; Provisional; Region: hscB; PRK05014 1048689008957 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1048689008958 HSP70 interaction site [polypeptide binding]; other site 1048689008959 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 1048689008960 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 1048689008961 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1048689008962 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1048689008963 trimerization site [polypeptide binding]; other site 1048689008964 active site 1048689008965 cysteine desulfurase; Provisional; Region: PRK14012 1048689008966 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1048689008967 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1048689008968 catalytic residue [active] 1048689008969 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 1048689008970 Rrf2 family protein; Region: rrf2_super; TIGR00738 1048689008971 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 1048689008972 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1048689008973 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1048689008974 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1048689008975 active site 1048689008976 dimerization interface [polypeptide binding]; other site 1048689008977 potential frameshift: common BLAST hit: gi|254162508|ref|YP_003045616.1| putative peptidase 1048689008978 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 1048689008979 PRD domain; Region: PRD; pfam00874 1048689008980 PRD domain; Region: PRD; pfam00874 1048689008981 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 1048689008982 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689008983 putative substrate translocation pore; other site 1048689008984 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1048689008985 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1048689008986 The C-terminal substrate binding domain of LysR-type transcriptional regulator HcaR in involved in 3-phenylpropionic acid catabolism, contains the type2 periplasmic binding fold; Region: PBP2_HcaR; cd08450 1048689008987 putative dimerization interface [polypeptide binding]; other site 1048689008988 putative substrate binding pocket [chemical binding]; other site 1048689008989 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1048689008990 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1048689008991 iron-sulfur cluster [ion binding]; other site 1048689008992 [2Fe-2S] cluster binding site [ion binding]; other site 1048689008993 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 1048689008994 beta subunit interface [polypeptide binding]; other site 1048689008995 alpha subunit interface [polypeptide binding]; other site 1048689008996 active site 1048689008997 substrate binding site [chemical binding]; other site 1048689008998 Fe binding site [ion binding]; other site 1048689008999 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 1048689009000 inter-subunit interface; other site 1048689009001 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 1048689009002 [2Fe-2S] cluster binding site [ion binding]; other site 1048689009003 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 1048689009004 cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase (BphB)-like, classical (c) SDRs; Region: BphB-like_SDR_c; cd05348 1048689009005 NAD binding site [chemical binding]; other site 1048689009006 active site 1048689009007 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1048689009008 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1048689009009 Predicted membrane protein [Function unknown]; Region: COG2259 1048689009010 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 1048689009011 active site 1048689009012 catalytic residues [active] 1048689009013 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1048689009014 L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239 1048689009015 putative NAD(P) binding site [chemical binding]; other site 1048689009016 catalytic Zn binding site [ion binding]; other site 1048689009017 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1048689009018 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1048689009019 TM-ABC transporter signature motif; other site 1048689009020 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1048689009021 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1048689009022 Walker A/P-loop; other site 1048689009023 ATP binding site [chemical binding]; other site 1048689009024 Q-loop/lid; other site 1048689009025 ABC transporter signature motif; other site 1048689009026 Walker B; other site 1048689009027 D-loop; other site 1048689009028 H-loop/switch region; other site 1048689009029 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1048689009030 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1048689009031 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1048689009032 ligand binding site [chemical binding]; other site 1048689009033 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1048689009034 TPR motif; other site 1048689009035 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1048689009036 binding surface 1048689009037 TPR repeat; Region: TPR_11; pfam13414 1048689009038 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1048689009039 TPR motif; other site 1048689009040 binding surface 1048689009041 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1048689009042 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1048689009043 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1048689009044 nucleotide binding site [chemical binding]; other site 1048689009045 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1048689009046 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1048689009047 dimer interface [polypeptide binding]; other site 1048689009048 active site 1048689009049 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1048689009050 folate binding site [chemical binding]; other site 1048689009051 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1048689009052 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1048689009053 heme-binding site [chemical binding]; other site 1048689009054 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1048689009055 FAD binding pocket [chemical binding]; other site 1048689009056 FAD binding motif [chemical binding]; other site 1048689009057 phosphate binding motif [ion binding]; other site 1048689009058 beta-alpha-beta structure motif; other site 1048689009059 NAD binding pocket [chemical binding]; other site 1048689009060 Heme binding pocket [chemical binding]; other site 1048689009061 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 1048689009062 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1048689009063 response regulator GlrR; Provisional; Region: PRK15115 1048689009064 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1048689009065 active site 1048689009066 phosphorylation site [posttranslational modification] 1048689009067 intermolecular recognition site; other site 1048689009068 dimerization interface [polypeptide binding]; other site 1048689009069 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1048689009070 Walker A motif; other site 1048689009071 ATP binding site [chemical binding]; other site 1048689009072 Walker B motif; other site 1048689009073 arginine finger; other site 1048689009074 hypothetical protein; Provisional; Region: PRK10722 1048689009075 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1048689009076 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1048689009077 dimer interface [polypeptide binding]; other site 1048689009078 phosphorylation site [posttranslational modification] 1048689009079 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1048689009080 ATP binding site [chemical binding]; other site 1048689009081 Mg2+ binding site [ion binding]; other site 1048689009082 G-X-G motif; other site 1048689009083 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 1048689009084 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1048689009085 dimerization interface [polypeptide binding]; other site 1048689009086 ATP binding site [chemical binding]; other site 1048689009087 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 1048689009088 dimerization interface [polypeptide binding]; other site 1048689009089 ATP binding site [chemical binding]; other site 1048689009090 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1048689009091 putative active site [active] 1048689009092 catalytic triad [active] 1048689009093 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 1048689009094 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1048689009095 substrate binding pocket [chemical binding]; other site 1048689009096 membrane-bound complex binding site; other site 1048689009097 hinge residues; other site 1048689009098 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1048689009099 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1048689009100 catalytic residue [active] 1048689009101 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1048689009102 nucleoside/Zn binding site; other site 1048689009103 dimer interface [polypeptide binding]; other site 1048689009104 catalytic motif [active] 1048689009105 hypothetical protein; Provisional; Region: PRK11590 1048689009106 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1048689009107 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1048689009108 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 1048689009109 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1048689009110 putative active site [active] 1048689009111 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1048689009112 holo-[acyl-carrier-protein] synthase; Region: acpS; TIGR00516 1048689009113 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 1048689009114 active site 1048689009115 hydrophilic channel; other site 1048689009116 dimerization interface [polypeptide binding]; other site 1048689009117 catalytic residues [active] 1048689009118 active site lid [active] 1048689009119 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1048689009120 Recombination protein O N terminal; Region: RecO_N; pfam11967 1048689009121 Recombination protein O C terminal; Region: RecO_C; pfam02565 1048689009122 GTPase Era; Reviewed; Region: era; PRK00089 1048689009123 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1048689009124 G1 box; other site 1048689009125 GTP/Mg2+ binding site [chemical binding]; other site 1048689009126 Switch I region; other site 1048689009127 G2 box; other site 1048689009128 Switch II region; other site 1048689009129 G3 box; other site 1048689009130 G4 box; other site 1048689009131 G5 box; other site 1048689009132 KH domain; Region: KH_2; pfam07650 1048689009133 ribonuclease III; Reviewed; Region: rnc; PRK00102 1048689009134 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1048689009135 dimerization interface [polypeptide binding]; other site 1048689009136 active site 1048689009137 metal binding site [ion binding]; metal-binding site 1048689009138 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1048689009139 dsRNA binding site [nucleotide binding]; other site 1048689009140 signal peptidase I; Provisional; Region: PRK10861 1048689009141 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1048689009142 Catalytic site [active] 1048689009143 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1048689009144 GTP-binding protein LepA; Provisional; Region: PRK05433 1048689009145 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1048689009146 G1 box; other site 1048689009147 putative GEF interaction site [polypeptide binding]; other site 1048689009148 GTP/Mg2+ binding site [chemical binding]; other site 1048689009149 Switch I region; other site 1048689009150 G2 box; other site 1048689009151 G3 box; other site 1048689009152 Switch II region; other site 1048689009153 G4 box; other site 1048689009154 G5 box; other site 1048689009155 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1048689009156 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1048689009157 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1048689009158 SoxR reducing system protein RseC; Provisional; Region: PRK10862 1048689009159 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 1048689009160 anti-sigma E factor; Provisional; Region: rseB; PRK09455 1048689009161 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 1048689009162 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 1048689009163 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 1048689009164 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 1048689009165 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1048689009166 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1048689009167 DNA binding residues [nucleotide binding] 1048689009168 L-aspartate oxidase; Provisional; Region: PRK09077 1048689009169 L-aspartate oxidase; Provisional; Region: PRK06175 1048689009170 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1048689009171 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1048689009172 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1048689009173 S-adenosylmethionine binding site [chemical binding]; other site 1048689009174 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 1048689009175 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1048689009176 ATP binding site [chemical binding]; other site 1048689009177 Mg++ binding site [ion binding]; other site 1048689009178 motif III; other site 1048689009179 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1048689009180 nucleotide binding region [chemical binding]; other site 1048689009181 ATP-binding site [chemical binding]; other site 1048689009182 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1048689009183 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1048689009184 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1048689009185 dimerization interface [polypeptide binding]; other site 1048689009186 cysteine/O-acetylserine exporter; Provisional; Region: PRK10323 1048689009187 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 1048689009188 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1048689009189 ligand binding site [chemical binding]; other site 1048689009190 active site 1048689009191 UGI interface [polypeptide binding]; other site 1048689009192 catalytic site [active] 1048689009193 putative methyltransferase; Provisional; Region: PRK10864 1048689009194 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1048689009195 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1048689009196 thioredoxin 2; Provisional; Region: PRK10996 1048689009197 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 1048689009198 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1048689009199 catalytic residues [active] 1048689009200 Uncharacterized conserved protein [Function unknown]; Region: COG3148 1048689009201 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 1048689009202 CoA binding domain; Region: CoA_binding_2; pfam13380 1048689009203 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1048689009204 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1048689009205 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1048689009206 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1048689009207 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 1048689009208 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 1048689009209 domain interface [polypeptide binding]; other site 1048689009210 putative active site [active] 1048689009211 catalytic site [active] 1048689009212 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 1048689009213 domain interface [polypeptide binding]; other site 1048689009214 putative active site [active] 1048689009215 catalytic site [active] 1048689009216 lipoprotein; Provisional; Region: PRK10759 1048689009217 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 1048689009218 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689009219 putative substrate translocation pore; other site 1048689009220 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1048689009221 protein disaggregation chaperone; Provisional; Region: PRK10865 1048689009222 Clp amino terminal domain; Region: Clp_N; pfam02861 1048689009223 Clp amino terminal domain; Region: Clp_N; pfam02861 1048689009224 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1048689009225 Walker A motif; other site 1048689009226 ATP binding site [chemical binding]; other site 1048689009227 Walker B motif; other site 1048689009228 arginine finger; other site 1048689009229 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1048689009230 Walker A motif; other site 1048689009231 ATP binding site [chemical binding]; other site 1048689009232 Walker B motif; other site 1048689009233 arginine finger; other site 1048689009234 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1048689009235 hypothetical protein; Provisional; Region: PRK10723 1048689009236 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1048689009237 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 1048689009238 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1048689009239 RNA binding surface [nucleotide binding]; other site 1048689009240 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1048689009241 active site 1048689009242 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 1048689009243 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 1048689009244 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1048689009245 30S subunit binding site; other site 1048689009246 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 1048689009247 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 1048689009248 Prephenate dehydratase; Region: PDT; pfam00800 1048689009249 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1048689009250 putative L-Phe binding site [chemical binding]; other site 1048689009251 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 1048689009252 Chorismate mutase type II; Region: CM_2; cl00693 1048689009253 prephenate dehydrogenase; Validated; Region: PRK08507 1048689009254 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 1048689009255 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1048689009256 lipoprotein; Provisional; Region: PRK11443 1048689009257 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 1048689009258 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 1048689009259 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 1048689009260 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1048689009261 metal binding site [ion binding]; metal-binding site 1048689009262 active site 1048689009263 I-site; other site 1048689009264 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 1048689009265 putative outer membrane lipoprotein; Provisional; Region: PRK09967 1048689009266 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1048689009267 ligand binding site [chemical binding]; other site 1048689009268 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1048689009269 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1048689009270 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1048689009271 RimM N-terminal domain; Region: RimM; pfam01782 1048689009272 PRC-barrel domain; Region: PRC; pfam05239 1048689009273 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1048689009274 signal recognition particle protein; Provisional; Region: PRK10867 1048689009275 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1048689009276 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1048689009277 P loop; other site 1048689009278 GTP binding site [chemical binding]; other site 1048689009279 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1048689009280 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 1048689009281 hypothetical protein; Provisional; Region: PRK11573 1048689009282 Domain of unknown function DUF21; Region: DUF21; pfam01595 1048689009283 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1048689009284 Transporter associated domain; Region: CorC_HlyC; smart01091 1048689009285 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1048689009286 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1048689009287 dimer interface [polypeptide binding]; other site 1048689009288 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1048689009289 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 1048689009290 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 1048689009291 recombination and repair protein; Provisional; Region: PRK10869 1048689009292 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1048689009293 Walker A/P-loop; other site 1048689009294 ATP binding site [chemical binding]; other site 1048689009295 Q-loop/lid; other site 1048689009296 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1048689009297 Q-loop/lid; other site 1048689009298 ABC transporter signature motif; other site 1048689009299 Walker B; other site 1048689009300 D-loop; other site 1048689009301 H-loop/switch region; other site 1048689009302 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 1048689009303 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 1048689009304 hypothetical protein; Validated; Region: PRK01777 1048689009305 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 1048689009306 putative coenzyme Q binding site [chemical binding]; other site 1048689009307 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1048689009308 SmpB-tmRNA interface; other site 1048689009309 prophage Cp12 1048689009310 integrase; Provisional; Region: PRK09692 1048689009311 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1048689009312 active site 1048689009313 Int/Topo IB signature motif; other site 1048689009314 sporadically distributed protein, TIGR04141 family; Region: TIGR04141 1048689009315 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1048689009316 His-Xaa-Ser system radical SAM maturase HxsC; Region: rSAM_pair_HxsC; TIGR03977 1048689009317 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1048689009318 FeS/SAM binding site; other site 1048689009319 His-Xaa-Ser system radical SAM maturase HxsB; Region: rSAM_paired_1; TIGR03978 1048689009320 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1048689009321 FeS/SAM binding site; other site 1048689009322 His-Xaa-Ser system protein HsxD; Region: chp_LLNDYxLRE; TIGR03976 1048689009323 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1048689009324 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1048689009325 AAA domain; Region: AAA_23; pfam13476 1048689009326 Walker A/P-loop; other site 1048689009327 ATP binding site [chemical binding]; other site 1048689009328 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 1048689009329 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1048689009330 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4688 1048689009331 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1048689009332 active site 1048689009333 catalytic residues [active] 1048689009334 DNA binding site [nucleotide binding] 1048689009335 Int/Topo IB signature motif; other site 1048689009336 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1048689009337 active site 1048689009338 catalytic residues [active] 1048689009339 DNA binding site [nucleotide binding] 1048689009340 Int/Topo IB signature motif; other site 1048689009341 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 1048689009342 potential frameshift: common BLAST hit: gi|254794598|ref|YP_003079435.1| adhesin-like autotransporter 1048689009343 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 1048689009344 substrate binding pocket [chemical binding]; other site 1048689009345 active site 1048689009346 iron coordination sites [ion binding]; other site 1048689009347 Predicted dehydrogenase [General function prediction only]; Region: COG0579 1048689009348 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1048689009349 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 1048689009350 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1048689009351 tetramerization interface [polypeptide binding]; other site 1048689009352 NAD(P) binding site [chemical binding]; other site 1048689009353 catalytic residues [active] 1048689009354 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 1048689009355 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1048689009356 inhibitor-cofactor binding pocket; inhibition site 1048689009357 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048689009358 catalytic residue [active] 1048689009359 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 1048689009360 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 1048689009361 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1048689009362 DNA-binding site [nucleotide binding]; DNA binding site 1048689009363 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1048689009364 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 1048689009365 bacterial OsmY and nodulation domain; Region: BON; smart00749 1048689009366 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1048689009367 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 1048689009368 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1048689009369 dimerization interface [polypeptide binding]; other site 1048689009370 putative DNA binding site [nucleotide binding]; other site 1048689009371 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1048689009372 putative Zn2+ binding site [ion binding]; other site 1048689009373 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YgaP, and similar uncharacterized putative rhodanese-related sulfurtransferases; Region: RHOD_YgaP; cd01527 1048689009374 active site residue [active] 1048689009375 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1048689009376 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 1048689009377 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 1048689009378 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 1048689009379 hypothetical protein; Provisional; Region: PRK10556 1048689009380 hypothetical protein; Provisional; Region: PRK10132 1048689009381 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1048689009382 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1048689009383 DNA-binding site [nucleotide binding]; DNA binding site 1048689009384 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1048689009385 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048689009386 homodimer interface [polypeptide binding]; other site 1048689009387 catalytic residue [active] 1048689009388 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1048689009389 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1048689009390 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1048689009391 catalytic residues [active] 1048689009392 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1048689009393 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 1048689009394 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1048689009395 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1048689009396 active site 1048689009397 dimer interface [polypeptide binding]; other site 1048689009398 catalytic residues [active] 1048689009399 effector binding site; other site 1048689009400 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1048689009401 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1048689009402 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1048689009403 dimer interface [polypeptide binding]; other site 1048689009404 putative radical transfer pathway; other site 1048689009405 diiron center [ion binding]; other site 1048689009406 tyrosyl radical; other site 1048689009407 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 1048689009408 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1048689009409 Walker A/P-loop; other site 1048689009410 ATP binding site [chemical binding]; other site 1048689009411 Q-loop/lid; other site 1048689009412 ABC transporter signature motif; other site 1048689009413 Walker B; other site 1048689009414 D-loop; other site 1048689009415 H-loop/switch region; other site 1048689009416 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1048689009417 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 1048689009418 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048689009419 dimer interface [polypeptide binding]; other site 1048689009420 conserved gate region; other site 1048689009421 putative PBP binding loops; other site 1048689009422 ABC-ATPase subunit interface; other site 1048689009423 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 1048689009424 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1048689009425 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1048689009426 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689009427 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1048689009428 putative L-valine exporter; Provisional; Region: PRK10408 1048689009429 transcriptional repressor MprA; Provisional; Region: PRK10870 1048689009430 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1048689009431 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 1048689009432 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1048689009433 HlyD family secretion protein; Region: HlyD_3; pfam13437 1048689009434 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1048689009435 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689009436 putative substrate translocation pore; other site 1048689009437 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689009438 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1048689009439 glutamate--cysteine ligase; Provisional; Region: PRK02107 1048689009440 Predicted membrane protein [Function unknown]; Region: COG1238 1048689009441 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 1048689009442 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1048689009443 motif II; other site 1048689009444 potential protein location (hypothetical protein ECO55CA74_15905 [Escherichia coli O55:H7 str. RM12579]) that overlaps RNA (tRNA-R) 1048689009445 carbon storage regulator; Provisional; Region: PRK01712 1048689009446 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1048689009447 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1048689009448 motif 1; other site 1048689009449 active site 1048689009450 motif 2; other site 1048689009451 motif 3; other site 1048689009452 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1048689009453 DHHA1 domain; Region: DHHA1; pfam02272 1048689009454 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1048689009455 recombinase A; Provisional; Region: recA; PRK09354 1048689009456 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1048689009457 hexamer interface [polypeptide binding]; other site 1048689009458 Walker A motif; other site 1048689009459 ATP binding site [chemical binding]; other site 1048689009460 Walker B motif; other site 1048689009461 hypothetical protein; Validated; Region: PRK03661 1048689009462 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1048689009463 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1048689009464 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1048689009465 PTS system, glucitol/sorbitol-specific, IIC component; Region: EII-GUT; TIGR00821 1048689009466 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 1048689009467 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 1048689009468 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 1048689009469 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 1048689009470 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 1048689009471 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 1048689009472 putative NAD(P) binding site [chemical binding]; other site 1048689009473 active site 1048689009474 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 1048689009475 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 1048689009476 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1048689009477 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1048689009478 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 1048689009479 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1048689009480 putative active site [active] 1048689009481 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1048689009482 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 1048689009483 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1048689009484 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1048689009485 Walker A motif; other site 1048689009486 ATP binding site [chemical binding]; other site 1048689009487 Walker B motif; other site 1048689009488 arginine finger; other site 1048689009489 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 1048689009490 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1048689009491 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1048689009492 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1048689009493 iron binding site [ion binding]; other site 1048689009494 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 1048689009495 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1048689009496 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 1048689009497 Acylphosphatase; Region: Acylphosphatase; pfam00708 1048689009498 HypF finger; Region: zf-HYPF; pfam07503 1048689009499 HypF finger; Region: zf-HYPF; pfam07503 1048689009500 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 1048689009501 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 1048689009502 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1048689009503 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1048689009504 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1048689009505 DNA binding site [nucleotide binding] 1048689009506 domain linker motif; other site 1048689009507 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1048689009508 dimerization interface (closed form) [polypeptide binding]; other site 1048689009509 ligand binding site [chemical binding]; other site 1048689009510 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 1048689009511 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1048689009512 active site turn [active] 1048689009513 phosphorylation site [posttranslational modification] 1048689009514 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 1048689009515 cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852 1048689009516 beta-galactosidase; Region: BGL; TIGR03356 1048689009517 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 1048689009518 nickel binding site [ion binding]; other site 1048689009519 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 1048689009520 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 1048689009521 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 1048689009522 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1048689009523 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 1048689009524 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 1048689009525 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1048689009526 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1048689009527 NADH dehydrogenase; Region: NADHdh; cl00469 1048689009528 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 1048689009529 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1048689009530 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 1048689009531 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 1048689009532 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 1048689009533 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 1048689009534 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 1048689009535 hydrogenase assembly chaperone; Provisional; Region: PRK10409 1048689009536 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 1048689009537 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 1048689009538 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 1048689009539 dimerization interface [polypeptide binding]; other site 1048689009540 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 1048689009541 ATP binding site [chemical binding]; other site 1048689009542 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 1048689009543 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1048689009544 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1048689009545 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1048689009546 Walker A motif; other site 1048689009547 ATP binding site [chemical binding]; other site 1048689009548 Walker B motif; other site 1048689009549 arginine finger; other site 1048689009550 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1048689009551 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 1048689009552 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1048689009553 MutS domain I; Region: MutS_I; pfam01624 1048689009554 MutS domain II; Region: MutS_II; pfam05188 1048689009555 MutS domain III; Region: MutS_III; pfam05192 1048689009556 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1048689009557 Walker A/P-loop; other site 1048689009558 ATP binding site [chemical binding]; other site 1048689009559 Q-loop/lid; other site 1048689009560 ABC transporter signature motif; other site 1048689009561 Walker B; other site 1048689009562 D-loop; other site 1048689009563 H-loop/switch region; other site 1048689009564 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 1048689009565 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1048689009566 active site 1048689009567 metal binding site [ion binding]; metal-binding site 1048689009568 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 1048689009569 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 1048689009570 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 1048689009571 Flavoprotein; Region: Flavoprotein; pfam02441 1048689009572 MarR family; Region: MarR_2; cl17246 1048689009573 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1048689009574 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 1048689009575 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1048689009576 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1048689009577 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1048689009578 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1048689009579 DNA binding residues [nucleotide binding] 1048689009580 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1048689009581 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1048689009582 Peptidase family M23; Region: Peptidase_M23; pfam01551 1048689009583 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 1048689009584 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1048689009585 S-adenosylmethionine binding site [chemical binding]; other site 1048689009586 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 1048689009587 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 1048689009588 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 1048689009589 Permutation of conserved domain; other site 1048689009590 active site 1048689009591 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1048689009592 homotrimer interaction site [polypeptide binding]; other site 1048689009593 zinc binding site [ion binding]; other site 1048689009594 CDP-binding sites; other site 1048689009595 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1048689009596 substrate binding site; other site 1048689009597 dimer interface; other site 1048689009598 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 1048689009599 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1048689009600 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 1048689009601 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1048689009602 ligand-binding site [chemical binding]; other site 1048689009603 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 1048689009604 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1048689009605 CysD dimerization site [polypeptide binding]; other site 1048689009606 G1 box; other site 1048689009607 putative GEF interaction site [polypeptide binding]; other site 1048689009608 GTP/Mg2+ binding site [chemical binding]; other site 1048689009609 Switch I region; other site 1048689009610 G2 box; other site 1048689009611 G3 box; other site 1048689009612 Switch II region; other site 1048689009613 G4 box; other site 1048689009614 G5 box; other site 1048689009615 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1048689009616 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1048689009617 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1048689009618 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1048689009619 Active Sites [active] 1048689009620 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 1048689009621 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 1048689009622 metal binding site [ion binding]; metal-binding site 1048689009623 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648 1048689009624 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 1048689009625 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09664 1048689009626 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 1048689009627 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 1048689009628 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cd09646 1048689009629 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09670 1048689009630 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09669 1048689009631 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1048689009632 CRISPR-associated helicase Cas3 [Defense mechanisms]; Region: COG1203 1048689009633 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1048689009634 Hok/gef family; Region: HOK_GEF; pfam01848 1048689009635 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1048689009636 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1048689009637 Active Sites [active] 1048689009638 sulfite reductase subunit beta; Provisional; Region: PRK13504 1048689009639 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1048689009640 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1048689009641 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 1048689009642 Flavodoxin; Region: Flavodoxin_1; pfam00258 1048689009643 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1048689009644 FAD binding pocket [chemical binding]; other site 1048689009645 FAD binding motif [chemical binding]; other site 1048689009646 catalytic residues [active] 1048689009647 NAD binding pocket [chemical binding]; other site 1048689009648 phosphate binding motif [ion binding]; other site 1048689009649 beta-alpha-beta structure motif; other site 1048689009650 6-pyruvoyl tetrahydropterin synthase (PTPS). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids, as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after uptake by a...; Region: PTPS; cd00470 1048689009651 homohexamer interface [polypeptide binding]; other site 1048689009652 putative substrate stabilizing pore; other site 1048689009653 pterin binding site; other site 1048689009654 putative oxidoreductase FixC; Provisional; Region: PRK10157 1048689009655 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 1048689009656 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 1048689009657 potential frameshift: common BLAST hit: gi|209920216|ref|YP_002294300.1| putative electron transfer flavoprotein 1048689009658 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1048689009659 Ligand binding site [chemical binding]; other site 1048689009660 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1048689009661 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 1048689009662 benzoate transport; Region: 2A0115; TIGR00895 1048689009663 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689009664 putative substrate translocation pore; other site 1048689009665 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1048689009666 FAD binding domain; Region: FAD_binding_4; pfam01565 1048689009667 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 1048689009668 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1048689009669 NADP binding site [chemical binding]; other site 1048689009670 homodimer interface [polypeptide binding]; other site 1048689009671 active site 1048689009672 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1048689009673 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689009674 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1048689009675 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1048689009676 nucleotide binding site [chemical binding]; other site 1048689009677 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 1048689009678 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 1048689009679 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 1048689009680 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 1048689009681 Repair protein; Region: Repair_PSII; pfam04536 1048689009682 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 1048689009683 Repair protein; Region: Repair_PSII; pfam04536 1048689009684 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 1048689009685 Repair protein; Region: Repair_PSII; pfam04536 1048689009686 enolase; Provisional; Region: eno; PRK00077 1048689009687 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1048689009688 dimer interface [polypeptide binding]; other site 1048689009689 metal binding site [ion binding]; metal-binding site 1048689009690 substrate binding pocket [chemical binding]; other site 1048689009691 CTP synthetase; Validated; Region: pyrG; PRK05380 1048689009692 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1048689009693 Catalytic site [active] 1048689009694 active site 1048689009695 UTP binding site [chemical binding]; other site 1048689009696 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1048689009697 active site 1048689009698 putative oxyanion hole; other site 1048689009699 catalytic triad [active] 1048689009700 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 1048689009701 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1048689009702 homodimer interface [polypeptide binding]; other site 1048689009703 metal binding site [ion binding]; metal-binding site 1048689009704 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1048689009705 homodimer interface [polypeptide binding]; other site 1048689009706 active site 1048689009707 putative chemical substrate binding site [chemical binding]; other site 1048689009708 metal binding site [ion binding]; metal-binding site 1048689009709 toxin MazF; Provisional; Region: PRK09907 1048689009710 antitoxin MazE; Provisional; Region: PRK09798 1048689009711 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 1048689009712 HD domain; Region: HD_4; pfam13328 1048689009713 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1048689009714 synthetase active site [active] 1048689009715 NTP binding site [chemical binding]; other site 1048689009716 metal binding site [ion binding]; metal-binding site 1048689009717 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1048689009718 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1048689009719 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 1048689009720 TRAM domain; Region: TRAM; pfam01938 1048689009721 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1048689009722 S-adenosylmethionine binding site [chemical binding]; other site 1048689009723 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 1048689009724 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 1048689009725 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1048689009726 dimerization interface [polypeptide binding]; other site 1048689009727 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1048689009728 dimer interface [polypeptide binding]; other site 1048689009729 phosphorylation site [posttranslational modification] 1048689009730 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1048689009731 ATP binding site [chemical binding]; other site 1048689009732 Mg2+ binding site [ion binding]; other site 1048689009733 G-X-G motif; other site 1048689009734 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 1048689009735 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1048689009736 active site 1048689009737 phosphorylation site [posttranslational modification] 1048689009738 intermolecular recognition site; other site 1048689009739 dimerization interface [polypeptide binding]; other site 1048689009740 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1048689009741 putative binding surface; other site 1048689009742 active site 1048689009743 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 1048689009744 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 1048689009745 active site 1048689009746 tetramer interface [polypeptide binding]; other site 1048689009747 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 1048689009748 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 1048689009749 active site 1048689009750 tetramer interface [polypeptide binding]; other site 1048689009751 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689009752 D-galactonate transporter; Region: 2A0114; TIGR00893 1048689009753 putative substrate translocation pore; other site 1048689009754 flavodoxin; Provisional; Region: PRK08105 1048689009755 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1048689009756 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 1048689009757 probable active site [active] 1048689009758 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 1048689009759 SecY interacting protein Syd; Provisional; Region: PRK04968 1048689009760 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 1048689009761 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 1048689009762 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 1048689009763 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1048689009764 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 1048689009765 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1048689009766 serine transporter; Region: stp; TIGR00814 1048689009767 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1048689009768 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1048689009769 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1048689009770 flap endonuclease-like protein; Provisional; Region: PRK09482 1048689009771 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1048689009772 active site 1048689009773 metal binding site 1 [ion binding]; metal-binding site 1048689009774 putative 5' ssDNA interaction site; other site 1048689009775 metal binding site 3; metal-binding site 1048689009776 metal binding site 2 [ion binding]; metal-binding site 1048689009777 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1048689009778 putative DNA binding site [nucleotide binding]; other site 1048689009779 putative metal binding site [ion binding]; other site 1048689009780 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 1048689009781 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 1048689009782 dimer interface [polypeptide binding]; other site 1048689009783 active site 1048689009784 metal binding site [ion binding]; metal-binding site 1048689009785 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1048689009786 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1048689009787 intersubunit interface [polypeptide binding]; other site 1048689009788 active site 1048689009789 Zn2+ binding site [ion binding]; other site 1048689009790 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1048689009791 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689009792 putative substrate translocation pore; other site 1048689009793 L-fucose isomerase; Provisional; Region: fucI; PRK10991 1048689009794 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 1048689009795 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1048689009796 trimer interface [polypeptide binding]; other site 1048689009797 substrate binding site [chemical binding]; other site 1048689009798 Mn binding site [ion binding]; other site 1048689009799 L-fuculokinase; Provisional; Region: PRK10331 1048689009800 L-fuculose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_FK; cd07773 1048689009801 putative N- and C-terminal domain interface [polypeptide binding]; other site 1048689009802 putative active site [active] 1048689009803 putative MgATP binding site [chemical binding]; other site 1048689009804 putative catalytic site [active] 1048689009805 metal binding site [ion binding]; metal-binding site 1048689009806 putative carbohydrate binding site [chemical binding]; other site 1048689009807 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 1048689009808 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 1048689009809 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1048689009810 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1048689009811 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 1048689009812 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1048689009813 hypothetical protein; Provisional; Region: PRK10873 1048689009814 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1048689009815 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1048689009816 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1048689009817 dimerization interface [polypeptide binding]; other site 1048689009818 substrate binding pocket [chemical binding]; other site 1048689009819 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1048689009820 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1048689009821 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1048689009822 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1048689009823 catalytic residue [active] 1048689009824 CsdA-binding activator; Provisional; Region: PRK15019 1048689009825 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 1048689009826 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1048689009827 putative ATP binding site [chemical binding]; other site 1048689009828 putative substrate interface [chemical binding]; other site 1048689009829 murein transglycosylase A; Provisional; Region: mltA; PRK11162 1048689009830 MltA specific insert domain; Region: MltA; pfam03562 1048689009831 3D domain; Region: 3D; pfam06725 1048689009832 AMIN domain; Region: AMIN; pfam11741 1048689009833 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1048689009834 active site 1048689009835 metal binding site [ion binding]; metal-binding site 1048689009836 N-acetylglutamate synthase; Validated; Region: PRK05279 1048689009837 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 1048689009838 putative feedback inhibition sensing region; other site 1048689009839 putative nucleotide binding site [chemical binding]; other site 1048689009840 putative substrate binding site [chemical binding]; other site 1048689009841 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1048689009842 Coenzyme A binding pocket [chemical binding]; other site 1048689009843 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 1048689009844 AAA domain; Region: AAA_30; pfam13604 1048689009845 Family description; Region: UvrD_C_2; pfam13538 1048689009846 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 1048689009847 protease3; Provisional; Region: PRK15101 1048689009848 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1048689009849 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1048689009850 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1048689009851 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1048689009852 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 1048689009853 hypothetical protein; Provisional; Region: PRK10332 1048689009854 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 1048689009855 hypothetical protein; Provisional; Region: PRK11521 1048689009856 hypothetical protein; Provisional; Region: PRK10557 1048689009857 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1048689009858 hypothetical protein; Provisional; Region: PRK10506 1048689009859 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1048689009860 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1048689009861 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1048689009862 dimerization interface [polypeptide binding]; other site 1048689009863 active site 1048689009864 prolipoprotein diacylglyceryl transferase; Region: lgt; TIGR00544 1048689009865 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 1048689009866 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1048689009867 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1048689009868 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1048689009869 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1048689009870 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 1048689009871 putative active site [active] 1048689009872 Ap4A binding site [chemical binding]; other site 1048689009873 nudix motif; other site 1048689009874 putative metal binding site [ion binding]; other site 1048689009875 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 1048689009876 putative DNA-binding cleft [nucleotide binding]; other site 1048689009877 putative DNA clevage site; other site 1048689009878 molecular lever; other site 1048689009879 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1048689009880 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1048689009881 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1048689009882 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1048689009883 active site 1048689009884 catalytic tetrad [active] 1048689009885 lysophospholipid transporter LplT; Provisional; Region: PRK11195 1048689009886 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689009887 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 1048689009888 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1048689009889 putative acyl-acceptor binding pocket; other site 1048689009890 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 1048689009891 acyl-activating enzyme (AAE) consensus motif; other site 1048689009892 putative AMP binding site [chemical binding]; other site 1048689009893 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 1048689009894 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1048689009895 DNA binding site [nucleotide binding] 1048689009896 domain linker motif; other site 1048689009897 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1048689009898 dimerization interface (closed form) [polypeptide binding]; other site 1048689009899 ligand binding site [chemical binding]; other site 1048689009900 diaminopimelate decarboxylase; Provisional; Region: PRK11165 1048689009901 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1048689009902 active site 1048689009903 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1048689009904 substrate binding site [chemical binding]; other site 1048689009905 catalytic residues [active] 1048689009906 dimer interface [polypeptide binding]; other site 1048689009907 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 1048689009908 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1048689009909 The C-terminal substrate binding domain of LysR, transcriptional regulator for lysine biosynthesis, contains the type 2 periplasmic binding fold; Region: PBP2_LysR; cd08456 1048689009910 putative dimerization interface [polypeptide binding]; other site 1048689009911 putative racemase; Provisional; Region: PRK10200 1048689009912 aspartate racemase; Region: asp_race; TIGR00035 1048689009913 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1048689009914 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689009915 putative substrate translocation pore; other site 1048689009916 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689009917 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 1048689009918 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1048689009919 NADP binding site [chemical binding]; other site 1048689009920 homodimer interface [polypeptide binding]; other site 1048689009921 active site 1048689009922 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 1048689009923 putative acyltransferase; Provisional; Region: PRK05790 1048689009924 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1048689009925 dimer interface [polypeptide binding]; other site 1048689009926 active site 1048689009927 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1048689009928 serine transporter; Region: stp; TIGR00814 1048689009929 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 1048689009930 DNA binding residues [nucleotide binding] 1048689009931 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 1048689009932 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 1048689009933 hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264 1048689009934 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 1048689009935 Tetratricopeptide repeat; Region: TPR_3; pfam07720 1048689009936 Tetratricopeptide repeat; Region: TPR_3; pfam07720 1048689009937 ATP synthase SpaL; Validated; Region: PRK08149 1048689009938 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 1048689009939 type III secretion system protein InvA; Provisional; Region: PRK15337 1048689009940 type III secretion system regulator InvE; Provisional; Region: PRK15338 1048689009941 HrpJ-like domain; Region: HrpJ; pfam07201 1048689009942 type III secretion system outer membrane pore InvG; Provisional; Region: PRK15339 1048689009943 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1048689009944 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1048689009945 transcriptional regulator InvF; Provisional; Region: PRK15340 1048689009946 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1048689009947 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 1048689009948 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1048689009949 Peptidase family M23; Region: Peptidase_M23; pfam01551 1048689009950 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 1048689009951 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 1048689009952 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1048689009953 xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971 1048689009954 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 1048689009955 xanthine dehydrogenase subunit XdhC; Provisional; Region: PRK09908 1048689009956 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1048689009957 catalytic loop [active] 1048689009958 iron binding site [ion binding]; other site 1048689009959 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1048689009960 GAF domain; Region: GAF; cl17456 1048689009961 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 1048689009962 PAS domain; Region: PAS; smart00091 1048689009963 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1048689009964 Walker A motif; other site 1048689009965 ATP binding site [chemical binding]; other site 1048689009966 Walker B motif; other site 1048689009967 arginine finger; other site 1048689009968 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1048689009969 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 1048689009970 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1048689009971 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1048689009972 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1048689009973 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 1048689009974 catalytic residue [active] 1048689009975 peptidase; Reviewed; Region: PRK13004 1048689009976 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 1048689009977 putative metal binding site [ion binding]; other site 1048689009978 putative dimer interface [polypeptide binding]; other site 1048689009979 D-hydantoinase; Region: D-hydantoinase; TIGR02033 1048689009980 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 1048689009981 tetramer interface [polypeptide binding]; other site 1048689009982 active site 1048689009983 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1048689009984 carbamate kinase; Reviewed; Region: PRK12686 1048689009985 putative substrate binding site [chemical binding]; other site 1048689009986 homodimer interface [polypeptide binding]; other site 1048689009987 nucleotide binding site [chemical binding]; other site 1048689009988 nucleotide binding site [chemical binding]; other site 1048689009989 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1048689009990 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1048689009991 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1048689009992 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 1048689009993 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1048689009994 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 1048689009995 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1048689009996 Ligand binding site; other site 1048689009997 metal-binding site 1048689009998 putative selenate reductase subunit YgfK; Provisional; Region: PRK09853 1048689009999 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1048689010000 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1048689010001 putative selenium metabolism protein SsnA; Region: Se_ssnA; TIGR03314 1048689010002 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1048689010003 active site 1048689010004 putative substrate binding pocket [chemical binding]; other site 1048689010005 probable selenate reductase, FAD-binding subunit; Region: Se_sel_red_FAD; TIGR03312 1048689010006 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 1048689010007 putative hypoxanthine oxidase; Provisional; Region: PRK09800 1048689010008 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1048689010009 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 1048689010010 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1048689010011 uracil-xanthine permease; Region: ncs2; TIGR00801 1048689010012 guanine deaminase; Provisional; Region: PRK09228 1048689010013 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 1048689010014 active site 1048689010015 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1048689010016 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 1048689010017 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12809 1048689010018 4Fe-4S binding domain; Region: Fer4; pfam00037 1048689010019 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1048689010020 xanthine permease; Region: pbuX; TIGR03173 1048689010021 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 1048689010022 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 1048689010023 active site 1048689010024 metal binding site [ion binding]; metal-binding site 1048689010025 nudix motif; other site 1048689010026 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1048689010027 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1048689010028 dimer interface [polypeptide binding]; other site 1048689010029 putative anticodon binding site; other site 1048689010030 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1048689010031 motif 1; other site 1048689010032 active site 1048689010033 motif 2; other site 1048689010034 motif 3; other site 1048689010035 peptide chain release factor 2; Provisional; Region: PRK08787 1048689010036 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1048689010037 RF-1 domain; Region: RF-1; pfam00472 1048689010038 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 1048689010039 DHH family; Region: DHH; pfam01368 1048689010040 DHHA1 domain; Region: DHHA1; pfam02272 1048689010041 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 1048689010042 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1048689010043 dimerization domain [polypeptide binding]; other site 1048689010044 dimer interface [polypeptide binding]; other site 1048689010045 catalytic residues [active] 1048689010046 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1048689010047 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1048689010048 active site 1048689010049 Int/Topo IB signature motif; other site 1048689010050 flavodoxin FldB; Provisional; Region: PRK12359 1048689010051 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 1048689010052 hypothetical protein; Provisional; Region: PRK10878 1048689010053 putative global regulator; Reviewed; Region: PRK09559 1048689010054 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1048689010055 hemolysin; Provisional; Region: PRK15087 1048689010056 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1048689010057 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 1048689010058 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 1048689010059 beta-galactosidase; Region: BGL; TIGR03356 1048689010060 glycine dehydrogenase; Provisional; Region: PRK05367 1048689010061 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1048689010062 tetramer interface [polypeptide binding]; other site 1048689010063 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048689010064 catalytic residue [active] 1048689010065 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1048689010066 tetramer interface [polypeptide binding]; other site 1048689010067 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048689010068 catalytic residue [active] 1048689010069 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1048689010070 lipoyl attachment site [posttranslational modification]; other site 1048689010071 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1048689010072 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1048689010073 oxidoreductase; Provisional; Region: PRK08013 1048689010074 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 1048689010075 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 1048689010076 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 1048689010077 proline aminopeptidase P II; Provisional; Region: PRK10879 1048689010078 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 1048689010079 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1048689010080 active site 1048689010081 hypothetical protein; Reviewed; Region: PRK01736 1048689010082 Z-ring-associated protein; Provisional; Region: PRK10972 1048689010083 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 1048689010084 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1048689010085 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1048689010086 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 1048689010087 ligand binding site [chemical binding]; other site 1048689010088 NAD binding site [chemical binding]; other site 1048689010089 tetramer interface [polypeptide binding]; other site 1048689010090 catalytic site [active] 1048689010091 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1048689010092 L-serine binding site [chemical binding]; other site 1048689010093 ACT domain interface; other site 1048689010094 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1048689010095 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1048689010096 active site 1048689010097 dimer interface [polypeptide binding]; other site 1048689010098 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1048689010099 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1048689010100 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 1048689010101 putative dimerization interface [polypeptide binding]; other site 1048689010102 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 1048689010103 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 1048689010104 active site 1048689010105 substrate binding site [chemical binding]; other site 1048689010106 coenzyme B12 binding site [chemical binding]; other site 1048689010107 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1048689010108 B12 binding site [chemical binding]; other site 1048689010109 cobalt ligand [ion binding]; other site 1048689010110 membrane ATPase/protein kinase; Provisional; Region: PRK09435 1048689010111 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1048689010112 Walker A; other site 1048689010113 methylmalonyl-CoA decarboxylase; Provisional; Region: PRK11423 1048689010114 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1048689010115 substrate binding site [chemical binding]; other site 1048689010116 oxyanion hole (OAH) forming residues; other site 1048689010117 trimer interface [polypeptide binding]; other site 1048689010118 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1048689010119 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 1048689010120 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1048689010121 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1048689010122 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1048689010123 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1048689010124 Uncharacterized conserved protein [Function unknown]; Region: COG2968 1048689010125 oxidative stress defense protein; Provisional; Region: PRK11087 1048689010126 arginine exporter protein; Provisional; Region: PRK09304 1048689010127 mechanosensitive channel MscS; Provisional; Region: PRK10334 1048689010128 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1048689010129 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1048689010130 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 1048689010131 active site 1048689010132 intersubunit interface [polypeptide binding]; other site 1048689010133 zinc binding site [ion binding]; other site 1048689010134 Na+ binding site [ion binding]; other site 1048689010135 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1048689010136 Phosphoglycerate kinase; Region: PGK; pfam00162 1048689010137 substrate binding site [chemical binding]; other site 1048689010138 hinge regions; other site 1048689010139 ADP binding site [chemical binding]; other site 1048689010140 catalytic site [active] 1048689010141 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 1048689010142 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1048689010143 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1048689010144 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 1048689010145 trimer interface [polypeptide binding]; other site 1048689010146 putative Zn binding site [ion binding]; other site 1048689010147 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1048689010148 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1048689010149 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1048689010150 Walker A/P-loop; other site 1048689010151 ATP binding site [chemical binding]; other site 1048689010152 Q-loop/lid; other site 1048689010153 ABC transporter signature motif; other site 1048689010154 Walker B; other site 1048689010155 D-loop; other site 1048689010156 H-loop/switch region; other site 1048689010157 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1048689010158 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1048689010159 Walker A/P-loop; other site 1048689010160 ATP binding site [chemical binding]; other site 1048689010161 Q-loop/lid; other site 1048689010162 ABC transporter signature motif; other site 1048689010163 Walker B; other site 1048689010164 D-loop; other site 1048689010165 H-loop/switch region; other site 1048689010166 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 1048689010167 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1048689010168 active site 1048689010169 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 1048689010170 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10022 1048689010171 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1048689010172 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1048689010173 putative active site [active] 1048689010174 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 1048689010175 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1048689010176 putative NAD(P) binding site [chemical binding]; other site 1048689010177 catalytic Zn binding site [ion binding]; other site 1048689010178 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 1048689010179 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1048689010180 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1048689010181 active site 1048689010182 P-loop; other site 1048689010183 phosphorylation site [posttranslational modification] 1048689010184 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1048689010185 active site 1048689010186 phosphorylation site [posttranslational modification] 1048689010187 transketolase; Reviewed; Region: PRK12753 1048689010188 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1048689010189 TPP-binding site [chemical binding]; other site 1048689010190 dimer interface [polypeptide binding]; other site 1048689010191 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1048689010192 PYR/PP interface [polypeptide binding]; other site 1048689010193 dimer interface [polypeptide binding]; other site 1048689010194 TPP binding site [chemical binding]; other site 1048689010195 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1048689010196 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1048689010197 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 1048689010198 agmatinase; Region: agmatinase; TIGR01230 1048689010199 oligomer interface [polypeptide binding]; other site 1048689010200 putative active site [active] 1048689010201 Mn binding site [ion binding]; other site 1048689010202 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 1048689010203 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 1048689010204 dimer interface [polypeptide binding]; other site 1048689010205 active site 1048689010206 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1048689010207 catalytic residues [active] 1048689010208 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1048689010209 Virulence promoting factor; Region: YqgB; pfam11036 1048689010210 Protein of unknown function (DUF2684); Region: DUF2684; pfam10885 1048689010211 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1048689010212 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1048689010213 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1048689010214 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1048689010215 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1048689010216 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689010217 putative substrate translocation pore; other site 1048689010218 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689010219 hypothetical protein; Provisional; Region: PRK04860 1048689010220 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 1048689010221 DNA-specific endonuclease I; Provisional; Region: PRK15137 1048689010222 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 1048689010223 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1048689010224 RNA methyltransferase, RsmE family; Region: TIGR00046 1048689010225 glutathione synthetase; Provisional; Region: PRK05246 1048689010226 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 1048689010227 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 1048689010228 hypothetical protein; Validated; Region: PRK00228 1048689010229 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1048689010230 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1048689010231 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 1048689010232 Walker A motif; other site 1048689010233 ATP binding site [chemical binding]; other site 1048689010234 Walker B motif; other site 1048689010235 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 1048689010236 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1048689010237 catalytic residue [active] 1048689010238 YGGT family; Region: YGGT; pfam02325 1048689010239 YGGT family; Region: YGGT; pfam02325 1048689010240 hypothetical protein; Validated; Region: PRK05090 1048689010241 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1048689010242 active site 1048689010243 dimerization interface [polypeptide binding]; other site 1048689010244 HemN family oxidoreductase; Provisional; Region: PRK05660 1048689010245 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1048689010246 FeS/SAM binding site; other site 1048689010247 HemN C-terminal domain; Region: HemN_C; pfam06969 1048689010248 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 1048689010249 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 1048689010250 homodimer interface [polypeptide binding]; other site 1048689010251 active site 1048689010252 hypothetical protein; Provisional; Region: PRK10626 1048689010253 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 1048689010254 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 1048689010255 hypothetical protein; Provisional; Region: PRK11702 1048689010256 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 1048689010257 adenine DNA glycosylase; Provisional; Region: PRK10880 1048689010258 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1048689010259 minor groove reading motif; other site 1048689010260 helix-hairpin-helix signature motif; other site 1048689010261 substrate binding pocket [chemical binding]; other site 1048689010262 active site 1048689010263 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1048689010264 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1048689010265 DNA binding and oxoG recognition site [nucleotide binding] 1048689010266 oxidative damage protection protein; Provisional; Region: PRK05408 1048689010267 murein transglycosylase C; Provisional; Region: mltC; PRK11671 1048689010268 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 1048689010269 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1048689010270 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1048689010271 catalytic residue [active] 1048689010272 nucleoside transporter; Region: 2A0110; TIGR00889 1048689010273 ornithine decarboxylase; Provisional; Region: PRK13578 1048689010274 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1048689010275 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1048689010276 homodimer interface [polypeptide binding]; other site 1048689010277 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048689010278 catalytic residue [active] 1048689010279 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1048689010280 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 1048689010281 integrase; Provisional; Region: PRK09692 1048689010282 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1048689010283 active site 1048689010284 Int/Topo IB signature motif; other site 1048689010285 phage-like element CpLE2 1048689010286 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1048689010287 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1048689010288 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1048689010289 Homeodomain-like domain; Region: HTH_23; pfam13384 1048689010290 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1048689010291 Transposase; Region: HTH_Tnp_1; pfam01527 1048689010292 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1048689010293 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1048689010294 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1048689010295 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1048689010296 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1048689010297 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1048689010298 Nuclease-related domain; Region: NERD; pfam08378 1048689010299 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 1048689010300 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 1048689010301 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 1048689010302 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 1048689010303 non-LEE encoded effector protein NleB; Provisional; Region: PRK15382 1048689010304 type III secretion system protein; Provisional; Region: PRK15384; cl14665 1048689010305 Homeodomain-like domain; Region: HTH_23; pfam13384 1048689010306 Winged helix-turn helix; Region: HTH_29; pfam13551 1048689010307 Homeodomain-like domain; Region: HTH_32; pfam13565 1048689010308 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1048689010309 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1048689010310 Block 172 1048689010311 potential frameshift: common BLAST hit: gi|260846954|ref|YP_003224732.1| Efa1/LifA-like protein 1048689010312 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1048689010313 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1048689010314 Transposase; Region: HTH_Tnp_1; pfam01527 1048689010315 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1048689010316 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1048689010317 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1048689010318 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1048689010319 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1048689010320 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1048689010321 Integrase core domain; Region: rve_2; pfam13333 1048689010322 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 1048689010323 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 1048689010324 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 1048689010325 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 1048689010326 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1048689010327 Haemolysin expression modulating protein; Region: HHA; cl11501 1048689010328 HTH-like domain; Region: HTH_21; pfam13276 1048689010329 Integrase core domain; Region: rve; pfam00665 1048689010330 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1048689010331 Integrase core domain; Region: rve_3; pfam13683 1048689010332 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1048689010333 Transposase; Region: HTH_Tnp_1; cl17663 1048689010334 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 1048689010335 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 1048689010336 hypothetical protein; Provisional; Region: PRK09945 1048689010337 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 1048689010338 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1048689010339 Autotransporter beta-domain; Region: Autotransporter; smart00869 1048689010340 Predicted GTPase [General function prediction only]; Region: COG3596 1048689010341 YfjP GTPase; Region: YfjP; cd11383 1048689010342 G1 box; other site 1048689010343 GTP/Mg2+ binding site [chemical binding]; other site 1048689010344 Switch I region; other site 1048689010345 G2 box; other site 1048689010346 Switch II region; other site 1048689010347 G3 box; other site 1048689010348 G4 box; other site 1048689010349 G5 box; other site 1048689010350 putative transposase OrfB; Reviewed; Region: PHA02517 1048689010351 HTH-like domain; Region: HTH_21; pfam13276 1048689010352 Integrase core domain; Region: rve; pfam00665 1048689010353 Integrase core domain; Region: rve_3; pfam13683 1048689010354 Transposase; Region: HTH_Tnp_1; cl17663 1048689010355 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 1048689010356 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1048689010357 Transposase; Region: HTH_Tnp_1; cl17663 1048689010358 HTH-like domain; Region: HTH_21; pfam13276 1048689010359 Integrase core domain; Region: rve; pfam00665 1048689010360 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1048689010361 Integrase core domain; Region: rve_3; pfam13683 1048689010362 Methyltransferase domain; Region: Methyltransf_27; pfam13708 1048689010363 putative general secretion pathway protein YghD; Provisional; Region: PRK09731 1048689010364 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 1048689010365 GspL-like protein; Provisional; Region: PRK09662 1048689010366 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 1048689010367 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1048689010368 type II secretion system protein J; Region: gspJ; TIGR01711 1048689010369 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 1048689010370 type II secretion system protein I; Region: gspI; TIGR01707 1048689010371 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 1048689010372 Prokaryotic N-terminal methylation motif; Region: N_methyl; pfam07963 1048689010373 Type II transport protein GspH; Region: GspH; pfam12019 1048689010374 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1048689010375 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 1048689010376 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1048689010377 type II secretion system protein F; Region: GspF; TIGR02120 1048689010378 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1048689010379 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1048689010380 type II secretion system protein E; Region: type_II_gspE; TIGR02533 1048689010381 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1048689010382 Walker A motif; other site 1048689010383 ATP binding site [chemical binding]; other site 1048689010384 Walker B motif; other site 1048689010385 type II secretion system protein D; Region: type_II_gspD; TIGR02517 1048689010386 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1048689010387 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1048689010388 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1048689010389 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1048689010390 putative type II secretion protein GspC; Provisional; Region: PRK09681 1048689010391 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 1048689010392 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1048689010393 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1048689010394 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1048689010395 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1048689010396 Domain of unknown function (DUF4092); Region: DUF4092; pfam13322 1048689010397 Peptidase M60-like family; Region: M60-like; pfam13402 1048689010398 glycolate transporter; Provisional; Region: PRK09695 1048689010399 L-lactate permease; Region: Lactate_perm; cl00701 1048689010400 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 1048689010401 active site 1048689010402 hypothetical protein; Provisional; Region: PRK09732 1048689010403 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 1048689010404 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1048689010405 Cysteine-rich domain; Region: CCG; pfam02754 1048689010406 Cysteine-rich domain; Region: CCG; pfam02754 1048689010407 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 1048689010408 FAD binding domain; Region: FAD_binding_4; pfam01565 1048689010409 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 1048689010410 FAD binding domain; Region: FAD_binding_4; pfam01565 1048689010411 DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990 1048689010412 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1048689010413 DNA-binding site [nucleotide binding]; DNA binding site 1048689010414 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1048689010415 acyl-CoA synthetase; Validated; Region: PRK09192 1048689010416 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1048689010417 acyl-activating enzyme (AAE) consensus motif; other site 1048689010418 active site 1048689010419 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1048689010420 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1048689010421 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1048689010422 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1048689010423 active site 1048689010424 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1048689010425 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1048689010426 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1048689010427 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1048689010428 catalytic residue [active] 1048689010429 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 1048689010430 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1048689010431 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1048689010432 Predicted permeases [General function prediction only]; Region: COG0795 1048689010433 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; pfam09695 1048689010434 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1048689010435 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1048689010436 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1048689010437 active site 1048689010438 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1048689010439 TMP-binding site; other site 1048689010440 ATP-binding site [chemical binding]; other site 1048689010441 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1048689010442 active site 1048689010443 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1048689010444 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1048689010445 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1048689010446 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 1048689010447 CHAP domain; Region: CHAP; pfam05257 1048689010448 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1048689010449 putative S-transferase; Provisional; Region: PRK11752 1048689010450 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1048689010451 C-terminal domain interface [polypeptide binding]; other site 1048689010452 GSH binding site (G-site) [chemical binding]; other site 1048689010453 dimer interface [polypeptide binding]; other site 1048689010454 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 1048689010455 dimer interface [polypeptide binding]; other site 1048689010456 N-terminal domain interface [polypeptide binding]; other site 1048689010457 active site 1048689010458 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 1048689010459 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 1048689010460 hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380 1048689010461 hydrogenase 2-specific chaperone; Provisional; Region: PRK10465 1048689010462 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 1048689010463 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 1048689010464 putative substrate-binding site; other site 1048689010465 nickel binding site [ion binding]; other site 1048689010466 hydrogenase 2 large subunit; Provisional; Region: PRK10467 1048689010467 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 1048689010468 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 1048689010469 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 1048689010470 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 1048689010471 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1048689010472 hydrogenase 2 small subunit; Provisional; Region: PRK10468 1048689010473 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 1048689010474 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 1048689010475 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 1048689010476 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1048689010477 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1048689010478 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1048689010479 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1048689010480 active site 1048689010481 catalytic tetrad [active] 1048689010482 hypothetical protein; Provisional; Region: PRK05208 1048689010483 oxidoreductase; Provisional; Region: PRK07985 1048689010484 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1048689010485 NAD binding site [chemical binding]; other site 1048689010486 metal binding site [ion binding]; metal-binding site 1048689010487 active site 1048689010488 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 1048689010489 biopolymer transport protein ExbD; Provisional; Region: PRK11267 1048689010490 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1048689010491 biopolymer transport protein ExbB; Provisional; Region: PRK10414 1048689010492 cystathionine beta-lyase; Provisional; Region: PRK08114 1048689010493 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1048689010494 homodimer interface [polypeptide binding]; other site 1048689010495 substrate-cofactor binding pocket; other site 1048689010496 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048689010497 catalytic residue [active] 1048689010498 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1048689010499 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1048689010500 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1048689010501 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1048689010502 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1048689010503 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1048689010504 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1048689010505 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1048689010506 dimer interface [polypeptide binding]; other site 1048689010507 active site 1048689010508 metal binding site [ion binding]; metal-binding site 1048689010509 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1048689010510 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1048689010511 active site 1048689010512 catalytic tetrad [active] 1048689010513 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 1048689010514 putative outer membrane lipoprotein; Provisional; Region: PRK09973 1048689010515 hypothetical protein; Provisional; Region: PRK01254 1048689010516 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 1048689010517 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 1048689010518 FtsI repressor; Provisional; Region: PRK10883 1048689010519 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1048689010520 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1048689010521 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 1048689010522 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1048689010523 putative acyl-acceptor binding pocket; other site 1048689010524 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 1048689010525 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1048689010526 CAP-like domain; other site 1048689010527 active site 1048689010528 primary dimer interface [polypeptide binding]; other site 1048689010529 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1048689010530 putative ABC transporter periplasmic-binding protein; Provisional; Region: PRK09755 1048689010531 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1048689010532 peptide binding site [polypeptide binding]; other site 1048689010533 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 1048689010534 TIGR00156 family protein; Region: TIGR00156 1048689010535 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 1048689010536 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1048689010537 active site 1048689010538 phosphorylation site [posttranslational modification] 1048689010539 intermolecular recognition site; other site 1048689010540 dimerization interface [polypeptide binding]; other site 1048689010541 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1048689010542 DNA binding site [nucleotide binding] 1048689010543 sensor protein QseC; Provisional; Region: PRK10337 1048689010544 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1048689010545 dimer interface [polypeptide binding]; other site 1048689010546 phosphorylation site [posttranslational modification] 1048689010547 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1048689010548 ATP binding site [chemical binding]; other site 1048689010549 Mg2+ binding site [ion binding]; other site 1048689010550 G-X-G motif; other site 1048689010551 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1048689010552 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1048689010553 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1048689010554 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1048689010555 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cd04795 1048689010556 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1048689010557 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1048689010558 siderophore binding site; other site 1048689010559 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1048689010560 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1048689010561 ABC-ATPase subunit interface; other site 1048689010562 dimer interface [polypeptide binding]; other site 1048689010563 putative PBP binding regions; other site 1048689010564 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1048689010565 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1048689010566 dimer interface [polypeptide binding]; other site 1048689010567 putative PBP binding regions; other site 1048689010568 ABC-ATPase subunit interface; other site 1048689010569 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1048689010570 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1048689010571 Walker A/P-loop; other site 1048689010572 ATP binding site [chemical binding]; other site 1048689010573 Q-loop/lid; other site 1048689010574 ABC transporter signature motif; other site 1048689010575 Walker B; other site 1048689010576 D-loop; other site 1048689010577 H-loop/switch region; other site 1048689010578 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1048689010579 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1048689010580 N-terminal plug; other site 1048689010581 ligand-binding site [chemical binding]; other site 1048689010582 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 1048689010583 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1048689010584 ATP binding site [chemical binding]; other site 1048689010585 Mg2+ binding site [ion binding]; other site 1048689010586 G-X-G motif; other site 1048689010587 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1048689010588 anchoring element; other site 1048689010589 dimer interface [polypeptide binding]; other site 1048689010590 ATP binding site [chemical binding]; other site 1048689010591 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1048689010592 active site 1048689010593 metal binding site [ion binding]; metal-binding site 1048689010594 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1048689010595 esterase YqiA; Provisional; Region: PRK11071 1048689010596 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1048689010597 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1048689010598 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1048689010599 active site 1048689010600 metal binding site [ion binding]; metal-binding site 1048689010601 hexamer interface [polypeptide binding]; other site 1048689010602 putative dehydrogenase; Provisional; Region: PRK11039 1048689010603 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 1048689010604 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1048689010605 dimer interface [polypeptide binding]; other site 1048689010606 ADP-ribose binding site [chemical binding]; other site 1048689010607 active site 1048689010608 nudix motif; other site 1048689010609 metal binding site [ion binding]; metal-binding site 1048689010610 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 1048689010611 hypothetical protein; Provisional; Region: PRK11653 1048689010612 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1048689010613 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1048689010614 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1048689010615 putative active site [active] 1048689010616 metal binding site [ion binding]; metal-binding site 1048689010617 zinc transporter ZupT; Provisional; Region: PRK04201 1048689010618 ZIP Zinc transporter; Region: Zip; pfam02535 1048689010619 Protein of unknown function (DUF4051); Region: DUF4051; pfam13260 1048689010620 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 1048689010621 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 1048689010622 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 1048689010623 glycogen synthesis protein GlgS; Provisional; Region: PRK02922 1048689010624 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 1048689010625 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 1048689010626 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 1048689010627 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 1048689010628 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 1048689010629 putative ribose interaction site [chemical binding]; other site 1048689010630 putative ADP binding site [chemical binding]; other site 1048689010631 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 1048689010632 active site 1048689010633 nucleotide binding site [chemical binding]; other site 1048689010634 HIGH motif; other site 1048689010635 KMSKS motif; other site 1048689010636 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 1048689010637 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1048689010638 metal binding triad; other site 1048689010639 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1048689010640 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1048689010641 metal binding triad; other site 1048689010642 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1048689010643 Uncharacterized conserved protein [Function unknown]; Region: COG3025 1048689010644 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 1048689010645 putative active site [active] 1048689010646 putative metal binding residues [ion binding]; other site 1048689010647 signature motif; other site 1048689010648 putative triphosphate binding site [ion binding]; other site 1048689010649 CHAD domain; Region: CHAD; pfam05235 1048689010650 SH3 domain-containing protein; Provisional; Region: PRK10884 1048689010651 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1048689010652 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 1048689010653 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1048689010654 active site 1048689010655 NTP binding site [chemical binding]; other site 1048689010656 metal binding triad [ion binding]; metal-binding site 1048689010657 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1048689010658 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1048689010659 Zn2+ binding site [ion binding]; other site 1048689010660 Mg2+ binding site [ion binding]; other site 1048689010661 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1048689010662 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1048689010663 homooctamer interface [polypeptide binding]; other site 1048689010664 active site 1048689010665 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1048689010666 transcriptional activator TtdR; Provisional; Region: PRK09801 1048689010667 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1048689010668 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 1048689010669 putative effector binding pocket; other site 1048689010670 putative dimerization interface [polypeptide binding]; other site 1048689010671 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 1048689010672 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 1048689010673 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1048689010674 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1048689010675 transmembrane helices; other site 1048689010676 UGMP family protein; Validated; Region: PRK09604 1048689010677 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1048689010678 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1048689010679 DNA primase; Validated; Region: dnaG; PRK05667 1048689010680 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1048689010681 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1048689010682 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1048689010683 active site 1048689010684 metal binding site [ion binding]; metal-binding site 1048689010685 interdomain interaction site; other site 1048689010686 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1048689010687 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 1048689010688 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 1048689010689 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1048689010690 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1048689010691 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 1048689010692 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1048689010693 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1048689010694 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1048689010695 DNA binding residues [nucleotide binding] 1048689010696 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 1048689010697 active site 1048689010698 SUMO-1 interface [polypeptide binding]; other site 1048689010699 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1048689010700 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1048689010701 FAD binding pocket [chemical binding]; other site 1048689010702 FAD binding motif [chemical binding]; other site 1048689010703 phosphate binding motif [ion binding]; other site 1048689010704 NAD binding pocket [chemical binding]; other site 1048689010705 Predicted transcriptional regulators [Transcription]; Region: COG1695 1048689010706 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1048689010707 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1048689010708 PAS fold; Region: PAS_3; pfam08447 1048689010709 putative active site [active] 1048689010710 heme pocket [chemical binding]; other site 1048689010711 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1048689010712 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1048689010713 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1048689010714 dimer interface [polypeptide binding]; other site 1048689010715 putative CheW interface [polypeptide binding]; other site 1048689010716 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 1048689010717 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1048689010718 inhibitor-cofactor binding pocket; inhibition site 1048689010719 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048689010720 catalytic residue [active] 1048689010721 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 1048689010722 dimer interface [polypeptide binding]; other site 1048689010723 putative tRNA-binding site [nucleotide binding]; other site 1048689010724 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 1048689010725 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1048689010726 DNA binding site [nucleotide binding] 1048689010727 domain linker motif; other site 1048689010728 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 1048689010729 putative dimerization interface [polypeptide binding]; other site 1048689010730 putative ligand binding site [chemical binding]; other site 1048689010731 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 1048689010732 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1048689010733 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1048689010734 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1048689010735 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 1048689010736 cryptic beta-D-galactosidase subunit beta; Reviewed; Region: ebgC; PRK10202 1048689010737 inner membrane transporter YjeM; Provisional; Region: PRK15238 1048689010738 alpha-glucosidase; Provisional; Region: PRK10137 1048689010739 Protein of unknown function, DUF608; Region: DUF608; pfam04685 1048689010740 Trehalase; Region: Trehalase; cl17346 1048689010741 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1048689010742 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 1048689010743 active site 1048689010744 FMN binding site [chemical binding]; other site 1048689010745 2,4-decadienoyl-CoA binding site; other site 1048689010746 catalytic residue [active] 1048689010747 4Fe-4S cluster binding site [ion binding]; other site 1048689010748 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1048689010749 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1048689010750 non-specific DNA binding site [nucleotide binding]; other site 1048689010751 salt bridge; other site 1048689010752 sequence-specific DNA binding site [nucleotide binding]; other site 1048689010753 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4680 1048689010754 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 1048689010755 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1048689010756 S-adenosylmethionine binding site [chemical binding]; other site 1048689010757 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 1048689010758 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1048689010759 putative active site [active] 1048689010760 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1048689010761 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1048689010762 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1048689010763 serine/threonine transporter SstT; Provisional; Region: PRK13628 1048689010764 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1048689010765 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 1048689010766 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1048689010767 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1048689010768 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1048689010769 Glucuronate isomerase; Region: UxaC; pfam02614 1048689010770 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1048689010771 D-galactonate transporter; Region: 2A0114; TIGR00893 1048689010772 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689010773 putative substrate translocation pore; other site 1048689010774 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 1048689010775 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1048689010776 DNA-binding site [nucleotide binding]; DNA binding site 1048689010777 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1048689010778 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1048689010779 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1048689010780 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 1048689010781 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 1048689010782 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 1048689010783 Predicted membrane protein [Function unknown]; Region: COG5393 1048689010784 YqjK-like protein; Region: YqjK; pfam13997 1048689010785 Predicted membrane protein [Function unknown]; Region: COG2259 1048689010786 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1048689010787 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 1048689010788 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1048689010789 putative dimer interface [polypeptide binding]; other site 1048689010790 N-terminal domain interface [polypeptide binding]; other site 1048689010791 putative substrate binding pocket (H-site) [chemical binding]; other site 1048689010792 Predicted membrane protein [Function unknown]; Region: COG3152 1048689010793 potential frameshift: common BLAST hit: gi|254795055|ref|YP_003079892.1| putative inner membrane protein 1048689010794 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1048689010795 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1048689010796 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1048689010797 dimerization interface [polypeptide binding]; other site 1048689010798 Pirin-related protein [General function prediction only]; Region: COG1741 1048689010799 Pirin; Region: Pirin; pfam02678 1048689010800 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 1048689010801 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1048689010802 serine transporter; Region: stp; TIGR00814 1048689010803 L-serine dehydratase TdcG; Provisional; Region: PRK15040 1048689010804 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1048689010805 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1048689010806 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1048689010807 homotrimer interaction site [polypeptide binding]; other site 1048689010808 putative active site [active] 1048689010809 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1048689010810 Pyruvate formate lyase 1; Region: PFL1; cd01678 1048689010811 coenzyme A binding site [chemical binding]; other site 1048689010812 active site 1048689010813 catalytic residues [active] 1048689010814 glycine loop; other site 1048689010815 propionate/acetate kinase; Provisional; Region: PRK12379 1048689010816 Acetokinase family; Region: Acetate_kinase; cl17229 1048689010817 threonine/serine transporter TdcC; Provisional; Region: PRK13629 1048689010818 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1048689010819 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1048689010820 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1048689010821 tetramer interface [polypeptide binding]; other site 1048689010822 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048689010823 catalytic residue [active] 1048689010824 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 1048689010825 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1048689010826 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 1048689010827 putative substrate binding pocket [chemical binding]; other site 1048689010828 putative dimerization interface [polypeptide binding]; other site 1048689010829 DNA-binding transcriptional activator TdcR; Provisional; Region: PRK11424 1048689010830 hypothetical protein; Provisional; Region: PRK09716 1048689010831 glycerate kinase I; Provisional; Region: PRK10342 1048689010832 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 1048689010833 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1048689010834 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 1048689010835 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689010836 D-galactonate transporter; Region: 2A0114; TIGR00893 1048689010837 putative substrate translocation pore; other site 1048689010838 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1048689010839 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1048689010840 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1048689010841 putative regulator PrlF; Provisional; Region: PRK09974 1048689010842 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1048689010843 Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663 1048689010844 DNA-binding transcriptional regulator AgaR; Provisional; Region: PRK09802 1048689010845 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1048689010846 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1048689010847 tagatose 6-phosphate aldolase subunit KbaZ; Provisional; Region: PRK15458 1048689010848 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1048689010849 active site 1048689010850 phosphorylation site [posttranslational modification] 1048689010851 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 1048689010852 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 1048689010853 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1048689010854 active pocket/dimerization site; other site 1048689010855 active site 1048689010856 phosphorylation site [posttranslational modification] 1048689010857 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1048689010858 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1048689010859 active site 1048689010860 dimer interface [polypeptide binding]; other site 1048689010861 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 1048689010862 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1048689010863 dimer interface [polypeptide binding]; other site 1048689010864 active site 1048689010865 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 1048689010866 putative active site [active] 1048689010867 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cd00453 1048689010868 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1048689010869 active site 1048689010870 intersubunit interface [polypeptide binding]; other site 1048689010871 zinc binding site [ion binding]; other site 1048689010872 Na+ binding site [ion binding]; other site 1048689010873 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1048689010874 active site 1048689010875 phosphorylation site [posttranslational modification] 1048689010876 PTS system N-acetylgalactosamine-specific transporter subunit IIC; Provisional; Region: PRK09757 1048689010877 PTS system N-acetylgalactosamine-specific transporter subunit IID; Provisional; Region: PRK09855 1048689010878 potential frameshift: common BLAST hit: gi|253772023|ref|YP_003034854.1| galactosamine-6-phosphate isomerase 1048689010879 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1048689010880 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1048689010881 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1048689010882 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1048689010883 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1048689010884 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1048689010885 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1048689010886 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1048689010887 PapC N-terminal domain; Region: PapC_N; pfam13954 1048689010888 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1048689010889 PapC C-terminal domain; Region: PapC_C; pfam13953 1048689010890 Fimbrial protein; Region: Fimbrial; pfam00419 1048689010891 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 1048689010892 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1048689010893 putative SAM binding site [chemical binding]; other site 1048689010894 putative homodimer interface [polypeptide binding]; other site 1048689010895 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1048689010896 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 1048689010897 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 1048689010898 putative ligand binding site [chemical binding]; other site 1048689010899 TIGR00252 family protein; Region: TIGR00252 1048689010900 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1048689010901 dimer interface [polypeptide binding]; other site 1048689010902 active site 1048689010903 outer membrane lipoprotein; Provisional; Region: PRK11023 1048689010904 BON domain; Region: BON; pfam04972 1048689010905 BON domain; Region: BON; pfam04972 1048689010906 Predicted permease; Region: DUF318; pfam03773 1048689010907 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 1048689010908 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1048689010909 NAD binding site [chemical binding]; other site 1048689010910 active site 1048689010911 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1048689010912 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1048689010913 proposed catalytic triad [active] 1048689010914 conserved cys residue [active] 1048689010915 hypothetical protein; Provisional; Region: PRK03467 1048689010916 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1048689010917 GIY-YIG motif/motif A; other site 1048689010918 putative active site [active] 1048689010919 putative metal binding site [ion binding]; other site 1048689010920 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1048689010921 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1048689010922 Coenzyme A binding pocket [chemical binding]; other site 1048689010923 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 1048689010924 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1048689010925 Peptidase family U32; Region: Peptidase_U32; pfam01136 1048689010926 putative protease; Provisional; Region: PRK15447 1048689010927 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1048689010928 hypothetical protein; Provisional; Region: PRK10508 1048689010929 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1048689010930 tryptophan permease; Provisional; Region: PRK10483 1048689010931 aromatic amino acid transport protein; Region: araaP; TIGR00837 1048689010932 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 1048689010933 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1048689010934 ATP binding site [chemical binding]; other site 1048689010935 Mg++ binding site [ion binding]; other site 1048689010936 motif III; other site 1048689010937 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1048689010938 nucleotide binding region [chemical binding]; other site 1048689010939 ATP-binding site [chemical binding]; other site 1048689010940 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 1048689010941 putative RNA binding site [nucleotide binding]; other site 1048689010942 lipoprotein NlpI; Provisional; Region: PRK11189 1048689010943 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1048689010944 binding surface 1048689010945 TPR motif; other site 1048689010946 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1048689010947 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1048689010948 RNase E interface [polypeptide binding]; other site 1048689010949 trimer interface [polypeptide binding]; other site 1048689010950 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1048689010951 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1048689010952 RNase E interface [polypeptide binding]; other site 1048689010953 trimer interface [polypeptide binding]; other site 1048689010954 active site 1048689010955 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1048689010956 putative nucleic acid binding region [nucleotide binding]; other site 1048689010957 G-X-X-G motif; other site 1048689010958 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1048689010959 RNA binding site [nucleotide binding]; other site 1048689010960 domain interface; other site 1048689010961 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1048689010962 16S/18S rRNA binding site [nucleotide binding]; other site 1048689010963 S13e-L30e interaction site [polypeptide binding]; other site 1048689010964 25S rRNA binding site [nucleotide binding]; other site 1048689010965 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 1048689010966 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1048689010967 RNA binding site [nucleotide binding]; other site 1048689010968 active site 1048689010969 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 1048689010970 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1048689010971 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1048689010972 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 1048689010973 translation initiation factor IF-2; Region: IF-2; TIGR00487 1048689010974 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1048689010975 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1048689010976 G1 box; other site 1048689010977 putative GEF interaction site [polypeptide binding]; other site 1048689010978 GTP/Mg2+ binding site [chemical binding]; other site 1048689010979 Switch I region; other site 1048689010980 G2 box; other site 1048689010981 G3 box; other site 1048689010982 Switch II region; other site 1048689010983 G4 box; other site 1048689010984 G5 box; other site 1048689010985 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1048689010986 Translation-initiation factor 2; Region: IF-2; pfam11987 1048689010987 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1048689010988 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 1048689010989 NusA N-terminal domain; Region: NusA_N; pfam08529 1048689010990 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1048689010991 RNA binding site [nucleotide binding]; other site 1048689010992 homodimer interface [polypeptide binding]; other site 1048689010993 NusA-like KH domain; Region: KH_5; pfam13184 1048689010994 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1048689010995 G-X-X-G motif; other site 1048689010996 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1048689010997 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1048689010998 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1048689010999 Sm and related proteins; Region: Sm_like; cl00259 1048689011000 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1048689011001 putative oligomer interface [polypeptide binding]; other site 1048689011002 putative RNA binding site [nucleotide binding]; other site 1048689011003 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1048689011004 ANP binding site [chemical binding]; other site 1048689011005 Substrate Binding Site II [chemical binding]; other site 1048689011006 Substrate Binding Site I [chemical binding]; other site 1048689011007 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 1048689011008 Sulfatase; Region: Sulfatase; pfam00884 1048689011009 Preprotein translocase SecG subunit; Region: SecG; pfam03840 1048689011010 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 1048689011011 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1048689011012 active site 1048689011013 substrate binding site [chemical binding]; other site 1048689011014 metal binding site [ion binding]; metal-binding site 1048689011015 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1048689011016 dihydropteroate synthase; Region: DHPS; TIGR01496 1048689011017 substrate binding pocket [chemical binding]; other site 1048689011018 dimer interface [polypeptide binding]; other site 1048689011019 inhibitor binding site; inhibition site 1048689011020 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 1048689011021 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1048689011022 Walker A motif; other site 1048689011023 ATP binding site [chemical binding]; other site 1048689011024 Walker B motif; other site 1048689011025 arginine finger; other site 1048689011026 Peptidase family M41; Region: Peptidase_M41; pfam01434 1048689011027 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 1048689011028 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1048689011029 S-adenosylmethionine binding site [chemical binding]; other site 1048689011030 RNA-binding protein YhbY; Provisional; Region: PRK10343 1048689011031 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1048689011032 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1048689011033 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1048689011034 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 1048689011035 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1048689011036 GTPase CgtA; Reviewed; Region: obgE; PRK12298 1048689011037 GTP1/OBG; Region: GTP1_OBG; pfam01018 1048689011038 Obg GTPase; Region: Obg; cd01898 1048689011039 G1 box; other site 1048689011040 GTP/Mg2+ binding site [chemical binding]; other site 1048689011041 Switch I region; other site 1048689011042 G2 box; other site 1048689011043 G3 box; other site 1048689011044 Switch II region; other site 1048689011045 G4 box; other site 1048689011046 G5 box; other site 1048689011047 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1048689011048 EamA-like transporter family; Region: EamA; pfam00892 1048689011049 EamA-like transporter family; Region: EamA; pfam00892 1048689011050 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1048689011051 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1048689011052 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1048689011053 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1048689011054 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1048689011055 substrate binding pocket [chemical binding]; other site 1048689011056 chain length determination region; other site 1048689011057 substrate-Mg2+ binding site; other site 1048689011058 catalytic residues [active] 1048689011059 aspartate-rich region 1; other site 1048689011060 active site lid residues [active] 1048689011061 aspartate-rich region 2; other site 1048689011062 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 1048689011063 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1048689011064 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1048689011065 hinge; other site 1048689011066 active site 1048689011067 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 1048689011068 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1048689011069 anti sigma factor interaction site; other site 1048689011070 regulatory phosphorylation site [posttranslational modification]; other site 1048689011071 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 1048689011072 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1048689011073 mce related protein; Region: MCE; pfam02470 1048689011074 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1048689011075 conserved hypothetical integral membrane protein; Region: TIGR00056 1048689011076 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 1048689011077 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1048689011078 Walker A/P-loop; other site 1048689011079 ATP binding site [chemical binding]; other site 1048689011080 Q-loop/lid; other site 1048689011081 ABC transporter signature motif; other site 1048689011082 Walker B; other site 1048689011083 D-loop; other site 1048689011084 H-loop/switch region; other site 1048689011085 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 1048689011086 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1048689011087 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1048689011088 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 1048689011089 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1048689011090 putative active site [active] 1048689011091 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1048689011092 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 1048689011093 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 1048689011094 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 1048689011095 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 1048689011096 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 1048689011097 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 1048689011098 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 1048689011099 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1048689011100 Walker A/P-loop; other site 1048689011101 ATP binding site [chemical binding]; other site 1048689011102 Q-loop/lid; other site 1048689011103 ABC transporter signature motif; other site 1048689011104 Walker B; other site 1048689011105 D-loop; other site 1048689011106 H-loop/switch region; other site 1048689011107 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1048689011108 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1048689011109 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1048689011110 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1048689011111 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1048689011112 30S subunit binding site; other site 1048689011113 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1048689011114 active site 1048689011115 phosphorylation site [posttranslational modification] 1048689011116 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 1048689011117 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1048689011118 dimerization domain swap beta strand [polypeptide binding]; other site 1048689011119 regulatory protein interface [polypeptide binding]; other site 1048689011120 active site 1048689011121 regulatory phosphorylation site [posttranslational modification]; other site 1048689011122 hypothetical protein; Provisional; Region: PRK10345 1048689011123 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 1048689011124 Transglycosylase; Region: Transgly; cl17702 1048689011125 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 1048689011126 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 1048689011127 conserved cys residue [active] 1048689011128 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 1048689011129 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1048689011130 putative active site [active] 1048689011131 heme pocket [chemical binding]; other site 1048689011132 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1048689011133 dimer interface [polypeptide binding]; other site 1048689011134 phosphorylation site [posttranslational modification] 1048689011135 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1048689011136 ATP binding site [chemical binding]; other site 1048689011137 Mg2+ binding site [ion binding]; other site 1048689011138 G-X-G motif; other site 1048689011139 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1048689011140 active site 1048689011141 phosphorylation site [posttranslational modification] 1048689011142 intermolecular recognition site; other site 1048689011143 dimerization interface [polypeptide binding]; other site 1048689011144 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1048689011145 putative binding surface; other site 1048689011146 active site 1048689011147 radical SAM protein, TIGR01212 family; Region: TIGR01212 1048689011148 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1048689011149 FeS/SAM binding site; other site 1048689011150 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1048689011151 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1048689011152 active site 1048689011153 dimer interface [polypeptide binding]; other site 1048689011154 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1048689011155 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1048689011156 active site 1048689011157 FMN binding site [chemical binding]; other site 1048689011158 substrate binding site [chemical binding]; other site 1048689011159 3Fe-4S cluster binding site [ion binding]; other site 1048689011160 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1048689011161 domain interface; other site 1048689011162 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 1048689011163 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1048689011164 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1048689011165 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 1048689011166 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 1048689011167 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 1048689011168 N-acetylmannosamine kinase; Provisional; Region: PRK05082 1048689011169 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1048689011170 nucleotide binding site [chemical binding]; other site 1048689011171 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1048689011172 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 1048689011173 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1048689011174 putative active site cavity [active] 1048689011175 putative sialic acid transporter; Provisional; Region: PRK03893 1048689011176 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689011177 putative substrate translocation pore; other site 1048689011178 N-acetylneuraminate lyase; Region: nanA; TIGR00683 1048689011179 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 1048689011180 inhibitor site; inhibition site 1048689011181 active site 1048689011182 dimer interface [polypeptide binding]; other site 1048689011183 catalytic residue [active] 1048689011184 transcriptional regulator NanR; Provisional; Region: PRK03837 1048689011185 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1048689011186 DNA-binding site [nucleotide binding]; DNA binding site 1048689011187 FCD domain; Region: FCD; pfam07729 1048689011188 putative cryptic C4-dicarboxylate transporter DcuD; Provisional; Region: PRK09804 1048689011189 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1048689011190 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 1048689011191 stringent starvation protein A; Provisional; Region: sspA; PRK09481 1048689011192 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 1048689011193 C-terminal domain interface [polypeptide binding]; other site 1048689011194 putative GSH binding site (G-site) [chemical binding]; other site 1048689011195 dimer interface [polypeptide binding]; other site 1048689011196 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 1048689011197 dimer interface [polypeptide binding]; other site 1048689011198 N-terminal domain interface [polypeptide binding]; other site 1048689011199 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1048689011200 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1048689011201 23S rRNA interface [nucleotide binding]; other site 1048689011202 L3 interface [polypeptide binding]; other site 1048689011203 Predicted ATPase [General function prediction only]; Region: COG1485 1048689011204 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 1048689011205 hypothetical protein; Provisional; Region: PRK11677 1048689011206 serine endoprotease; Provisional; Region: PRK10139 1048689011207 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1048689011208 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1048689011209 protein binding site [polypeptide binding]; other site 1048689011210 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1048689011211 serine endoprotease; Provisional; Region: PRK10898 1048689011212 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1048689011213 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1048689011214 malate dehydrogenase; Provisional; Region: PRK05086 1048689011215 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 1048689011216 NAD binding site [chemical binding]; other site 1048689011217 dimerization interface [polypeptide binding]; other site 1048689011218 Substrate binding site [chemical binding]; other site 1048689011219 arginine repressor; Provisional; Region: PRK05066 1048689011220 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1048689011221 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1048689011222 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1048689011223 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 1048689011224 RNAase interaction site [polypeptide binding]; other site 1048689011225 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 1048689011226 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1048689011227 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 1048689011228 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1048689011229 HlyD family secretion protein; Region: HlyD_3; pfam13437 1048689011230 efflux system membrane protein; Provisional; Region: PRK11594 1048689011231 transcriptional regulator; Provisional; Region: PRK10632 1048689011232 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1048689011233 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1048689011234 putative effector binding pocket; other site 1048689011235 dimerization interface [polypeptide binding]; other site 1048689011236 protease TldD; Provisional; Region: tldD; PRK10735 1048689011237 hypothetical protein; Provisional; Region: PRK10899 1048689011238 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1048689011239 ribonuclease G; Provisional; Region: PRK11712 1048689011240 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1048689011241 homodimer interface [polypeptide binding]; other site 1048689011242 oligonucleotide binding site [chemical binding]; other site 1048689011243 Maf-like protein; Region: Maf; pfam02545 1048689011244 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1048689011245 active site 1048689011246 dimer interface [polypeptide binding]; other site 1048689011247 rod shape-determining protein MreD; Provisional; Region: PRK11060 1048689011248 rod shape-determining protein MreC; Region: mreC; TIGR00219 1048689011249 rod shape-determining protein MreC; Region: MreC; pfam04085 1048689011250 rod shape-determining protein MreB; Provisional; Region: PRK13927 1048689011251 MreB and similar proteins; Region: MreB_like; cd10225 1048689011252 nucleotide binding site [chemical binding]; other site 1048689011253 Mg binding site [ion binding]; other site 1048689011254 putative protofilament interaction site [polypeptide binding]; other site 1048689011255 RodZ interaction site [polypeptide binding]; other site 1048689011256 regulatory protein CsrD; Provisional; Region: PRK11059 1048689011257 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1048689011258 metal binding site [ion binding]; metal-binding site 1048689011259 active site 1048689011260 I-site; other site 1048689011261 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1048689011262 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 1048689011263 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1048689011264 NADP binding site [chemical binding]; other site 1048689011265 dimer interface [polypeptide binding]; other site 1048689011266 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 1048689011267 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1048689011268 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1048689011269 carboxyltransferase (CT) interaction site; other site 1048689011270 biotinylation site [posttranslational modification]; other site 1048689011271 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1048689011272 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1048689011273 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1048689011274 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1048689011275 hypothetical protein; Provisional; Region: PRK10633 1048689011276 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 1048689011277 Na binding site [ion binding]; other site 1048689011278 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1048689011279 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1048689011280 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 1048689011281 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1048689011282 FMN binding site [chemical binding]; other site 1048689011283 active site 1048689011284 catalytic residues [active] 1048689011285 substrate binding site [chemical binding]; other site 1048689011286 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 1048689011287 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 1048689011288 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1048689011289 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1048689011290 DNA methylase; Region: N6_N4_Mtase; pfam01555 1048689011291 Protein of unknown function (DUF2556); Region: DUF2556; pfam10831 1048689011292 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 1048689011293 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1048689011294 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 1048689011295 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 1048689011296 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1048689011297 HlyD family secretion protein; Region: HlyD_3; pfam13437 1048689011298 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1048689011299 Protein export membrane protein; Region: SecD_SecF; cl14618 1048689011300 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1048689011301 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1048689011302 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1048689011303 substrate binding pocket [chemical binding]; other site 1048689011304 membrane-bound complex binding site; other site 1048689011305 hinge residues; other site 1048689011306 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 1048689011307 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048689011308 conserved gate region; other site 1048689011309 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048689011310 dimer interface [polypeptide binding]; other site 1048689011311 conserved gate region; other site 1048689011312 putative PBP binding loops; other site 1048689011313 ABC-ATPase subunit interface; other site 1048689011314 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1048689011315 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048689011316 dimer interface [polypeptide binding]; other site 1048689011317 conserved gate region; other site 1048689011318 putative PBP binding loops; other site 1048689011319 ABC-ATPase subunit interface; other site 1048689011320 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1048689011321 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1048689011322 Walker A/P-loop; other site 1048689011323 ATP binding site [chemical binding]; other site 1048689011324 Q-loop/lid; other site 1048689011325 ABC transporter signature motif; other site 1048689011326 Walker B; other site 1048689011327 D-loop; other site 1048689011328 H-loop/switch region; other site 1048689011329 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1048689011330 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1048689011331 trimer interface [polypeptide binding]; other site 1048689011332 putative metal binding site [ion binding]; other site 1048689011333 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 1048689011334 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 1048689011335 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1048689011336 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1048689011337 shikimate binding site; other site 1048689011338 NAD(P) binding site [chemical binding]; other site 1048689011339 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 1048689011340 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1048689011341 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 1048689011342 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1048689011343 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1048689011344 hypothetical protein; Validated; Region: PRK03430 1048689011345 hypothetical protein; Provisional; Region: PRK10736 1048689011346 DNA protecting protein DprA; Region: dprA; TIGR00732 1048689011347 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1048689011348 active site 1048689011349 catalytic residues [active] 1048689011350 metal binding site [ion binding]; metal-binding site 1048689011351 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1048689011352 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1048689011353 putative active site [active] 1048689011354 substrate binding site [chemical binding]; other site 1048689011355 putative cosubstrate binding site; other site 1048689011356 catalytic site [active] 1048689011357 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1048689011358 substrate binding site [chemical binding]; other site 1048689011359 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 1048689011360 putative RNA binding site [nucleotide binding]; other site 1048689011361 16S rRNA methyltransferase B; Provisional; Region: PRK10901 1048689011362 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1048689011363 S-adenosylmethionine binding site [chemical binding]; other site 1048689011364 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 1048689011365 TrkA-N domain; Region: TrkA_N; pfam02254 1048689011366 TrkA-C domain; Region: TrkA_C; pfam02080 1048689011367 TrkA-N domain; Region: TrkA_N; pfam02254 1048689011368 TrkA-C domain; Region: TrkA_C; pfam02080 1048689011369 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1048689011370 Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741 1048689011371 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 1048689011372 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 1048689011373 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 1048689011374 DNA binding residues [nucleotide binding] 1048689011375 dimer interface [polypeptide binding]; other site 1048689011376 metal binding site [ion binding]; metal-binding site 1048689011377 hypothetical protein; Provisional; Region: PRK10203 1048689011378 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1048689011379 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1048689011380 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1048689011381 alphaNTD homodimer interface [polypeptide binding]; other site 1048689011382 alphaNTD - beta interaction site [polypeptide binding]; other site 1048689011383 alphaNTD - beta' interaction site [polypeptide binding]; other site 1048689011384 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1048689011385 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1048689011386 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1048689011387 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1048689011388 RNA binding surface [nucleotide binding]; other site 1048689011389 30S ribosomal protein S11; Validated; Region: PRK05309 1048689011390 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1048689011391 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1048689011392 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 1048689011393 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1048689011394 SecY translocase; Region: SecY; pfam00344 1048689011395 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1048689011396 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1048689011397 23S rRNA binding site [nucleotide binding]; other site 1048689011398 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1048689011399 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1048689011400 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1048689011401 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1048689011402 23S rRNA interface [nucleotide binding]; other site 1048689011403 5S rRNA interface [nucleotide binding]; other site 1048689011404 L27 interface [polypeptide binding]; other site 1048689011405 L5 interface [polypeptide binding]; other site 1048689011406 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1048689011407 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1048689011408 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1048689011409 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1048689011410 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1048689011411 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1048689011412 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1048689011413 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1048689011414 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1048689011415 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1048689011416 RNA binding site [nucleotide binding]; other site 1048689011417 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1048689011418 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1048689011419 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1048689011420 23S rRNA interface [nucleotide binding]; other site 1048689011421 putative translocon interaction site; other site 1048689011422 signal recognition particle (SRP54) interaction site; other site 1048689011423 L23 interface [polypeptide binding]; other site 1048689011424 trigger factor interaction site; other site 1048689011425 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1048689011426 23S rRNA interface [nucleotide binding]; other site 1048689011427 5S rRNA interface [nucleotide binding]; other site 1048689011428 putative antibiotic binding site [chemical binding]; other site 1048689011429 L25 interface [polypeptide binding]; other site 1048689011430 L27 interface [polypeptide binding]; other site 1048689011431 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1048689011432 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1048689011433 G-X-X-G motif; other site 1048689011434 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1048689011435 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1048689011436 protein-rRNA interface [nucleotide binding]; other site 1048689011437 putative translocon binding site; other site 1048689011438 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1048689011439 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1048689011440 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1048689011441 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1048689011442 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1048689011443 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1048689011444 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 1048689011445 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1048689011446 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1048689011447 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1048689011448 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1048689011449 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1048689011450 heme binding site [chemical binding]; other site 1048689011451 ferroxidase pore; other site 1048689011452 ferroxidase diiron center [ion binding]; other site 1048689011453 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 1048689011454 elongation factor Tu; Reviewed; Region: PRK00049 1048689011455 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1048689011456 G1 box; other site 1048689011457 GEF interaction site [polypeptide binding]; other site 1048689011458 GTP/Mg2+ binding site [chemical binding]; other site 1048689011459 Switch I region; other site 1048689011460 G2 box; other site 1048689011461 G3 box; other site 1048689011462 Switch II region; other site 1048689011463 G4 box; other site 1048689011464 G5 box; other site 1048689011465 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1048689011466 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1048689011467 Antibiotic Binding Site [chemical binding]; other site 1048689011468 elongation factor G; Reviewed; Region: PRK00007 1048689011469 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1048689011470 G1 box; other site 1048689011471 putative GEF interaction site [polypeptide binding]; other site 1048689011472 GTP/Mg2+ binding site [chemical binding]; other site 1048689011473 Switch I region; other site 1048689011474 G2 box; other site 1048689011475 G3 box; other site 1048689011476 Switch II region; other site 1048689011477 G4 box; other site 1048689011478 G5 box; other site 1048689011479 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1048689011480 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1048689011481 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1048689011482 30S ribosomal protein S7; Validated; Region: PRK05302 1048689011483 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1048689011484 S17 interaction site [polypeptide binding]; other site 1048689011485 S8 interaction site; other site 1048689011486 16S rRNA interaction site [nucleotide binding]; other site 1048689011487 streptomycin interaction site [chemical binding]; other site 1048689011488 23S rRNA interaction site [nucleotide binding]; other site 1048689011489 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1048689011490 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 1048689011491 sulfur relay protein TusC; Validated; Region: PRK00211 1048689011492 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 1048689011493 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 1048689011494 YheO-like PAS domain; Region: PAS_6; pfam08348 1048689011495 HTH domain; Region: HTH_22; pfam13309 1048689011496 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 1048689011497 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1048689011498 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1048689011499 phi X174 lysis protein; Provisional; Region: PRK02793 1048689011500 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 1048689011501 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1048689011502 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 1048689011503 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 1048689011504 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 1048689011505 TrkA-N domain; Region: TrkA_N; pfam02254 1048689011506 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 1048689011507 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 1048689011508 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1048689011509 Walker A/P-loop; other site 1048689011510 ATP binding site [chemical binding]; other site 1048689011511 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1048689011512 ABC transporter signature motif; other site 1048689011513 Walker B; other site 1048689011514 D-loop; other site 1048689011515 ABC transporter; Region: ABC_tran_2; pfam12848 1048689011516 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1048689011517 putative hydrolase; Provisional; Region: PRK10985 1048689011518 hypothetical protein; Provisional; Region: PRK04966 1048689011519 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 1048689011520 active site 1048689011521 hypothetical protein; Provisional; Region: PRK10738 1048689011522 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 1048689011523 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1048689011524 ligand binding site [chemical binding]; other site 1048689011525 flexible hinge region; other site 1048689011526 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1048689011527 putative switch regulator; other site 1048689011528 non-specific DNA interactions [nucleotide binding]; other site 1048689011529 DNA binding site [nucleotide binding] 1048689011530 sequence specific DNA binding site [nucleotide binding]; other site 1048689011531 putative cAMP binding site [chemical binding]; other site 1048689011532 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 1048689011533 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1048689011534 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1048689011535 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 1048689011536 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1048689011537 inhibitor-cofactor binding pocket; inhibition site 1048689011538 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048689011539 catalytic residue [active] 1048689011540 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1048689011541 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1048689011542 glutamine binding [chemical binding]; other site 1048689011543 catalytic triad [active] 1048689011544 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 1048689011545 cell filamentation protein Fic; Provisional; Region: PRK10347 1048689011546 hypothetical protein; Provisional; Region: PRK10204 1048689011547 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 1048689011548 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1048689011549 substrate binding site [chemical binding]; other site 1048689011550 putative transporter; Provisional; Region: PRK03699 1048689011551 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689011552 putative substrate translocation pore; other site 1048689011553 nitrite reductase subunit NirD; Provisional; Region: PRK14989 1048689011554 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1048689011555 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1048689011556 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1048689011557 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1048689011558 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1048689011559 nitrite transporter NirC; Provisional; Region: PRK11562 1048689011560 siroheme synthase; Provisional; Region: cysG; PRK10637 1048689011561 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1048689011562 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 1048689011563 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1048689011564 active site 1048689011565 SAM binding site [chemical binding]; other site 1048689011566 homodimer interface [polypeptide binding]; other site 1048689011567 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 1048689011568 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 1048689011569 hypothetical protein; Provisional; Region: PHA02764 1048689011570 fructoselysine-6-P-deglycase; Provisional; Region: frlB; PRK11382 1048689011571 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1048689011572 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1048689011573 dimer interface [polypeptide binding]; other site 1048689011574 active site 1048689011575 fructoselysine 3-epimerase; Provisional; Region: PRK09856 1048689011576 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1048689011577 AP (apurinic/apyrimidinic) site pocket; other site 1048689011578 DNA interaction; other site 1048689011579 Metal-binding active site; metal-binding site 1048689011580 potential frameshift: common BLAST hit: gi|260846158|ref|YP_003223936.1| fructoselysine 6-kinase 1048689011581 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 1048689011582 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1048689011583 DNA-binding site [nucleotide binding]; DNA binding site 1048689011584 UTRA domain; Region: UTRA; pfam07702 1048689011585 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1048689011586 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1048689011587 active site 1048689011588 HIGH motif; other site 1048689011589 dimer interface [polypeptide binding]; other site 1048689011590 KMSKS motif; other site 1048689011591 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1048689011592 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1048689011593 motif II; other site 1048689011594 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1048689011595 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1048689011596 substrate binding site [chemical binding]; other site 1048689011597 hexamer interface [polypeptide binding]; other site 1048689011598 metal binding site [ion binding]; metal-binding site 1048689011599 DNA adenine methylase; Provisional; Region: PRK10904 1048689011600 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 1048689011601 cell division protein DamX; Validated; Region: PRK10905 1048689011602 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1048689011603 active site 1048689011604 dimer interface [polypeptide binding]; other site 1048689011605 metal binding site [ion binding]; metal-binding site 1048689011606 shikimate kinase; Reviewed; Region: aroK; PRK00131 1048689011607 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1048689011608 ADP binding site [chemical binding]; other site 1048689011609 magnesium binding site [ion binding]; other site 1048689011610 putative shikimate binding site; other site 1048689011611 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 1048689011612 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1048689011613 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1048689011614 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 1048689011615 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 1048689011616 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 1048689011617 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 1048689011618 Transglycosylase; Region: Transgly; pfam00912 1048689011619 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1048689011620 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 1048689011621 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1048689011622 ADP-ribose binding site [chemical binding]; other site 1048689011623 dimer interface [polypeptide binding]; other site 1048689011624 active site 1048689011625 nudix motif; other site 1048689011626 metal binding site [ion binding]; metal-binding site 1048689011627 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 1048689011628 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1048689011629 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1048689011630 motif II; other site 1048689011631 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1048689011632 RNA binding surface [nucleotide binding]; other site 1048689011633 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1048689011634 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1048689011635 dimerization interface [polypeptide binding]; other site 1048689011636 domain crossover interface; other site 1048689011637 redox-dependent activation switch; other site 1048689011638 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 1048689011639 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1048689011640 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1048689011641 active site 1048689011642 substrate-binding site [chemical binding]; other site 1048689011643 metal-binding site [ion binding] 1048689011644 ATP binding site [chemical binding]; other site 1048689011645 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 1048689011646 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1048689011647 dimerization interface [polypeptide binding]; other site 1048689011648 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1048689011649 dimer interface [polypeptide binding]; other site 1048689011650 phosphorylation site [posttranslational modification] 1048689011651 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1048689011652 ATP binding site [chemical binding]; other site 1048689011653 G-X-G motif; other site 1048689011654 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1048689011655 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1048689011656 active site 1048689011657 phosphorylation site [posttranslational modification] 1048689011658 intermolecular recognition site; other site 1048689011659 dimerization interface [polypeptide binding]; other site 1048689011660 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1048689011661 DNA binding site [nucleotide binding] 1048689011662 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 1048689011663 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1048689011664 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1048689011665 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1048689011666 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1048689011667 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1048689011668 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1048689011669 RNA binding site [nucleotide binding]; other site 1048689011670 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 1048689011671 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 1048689011672 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1048689011673 G1 box; other site 1048689011674 GTP/Mg2+ binding site [chemical binding]; other site 1048689011675 Switch I region; other site 1048689011676 G2 box; other site 1048689011677 G3 box; other site 1048689011678 Switch II region; other site 1048689011679 G4 box; other site 1048689011680 G5 box; other site 1048689011681 Nucleoside recognition; Region: Gate; pfam07670 1048689011682 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1048689011683 Nucleoside recognition; Region: Gate; pfam07670 1048689011684 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 1048689011685 putative transposase; Provisional; Region: PRK09857 1048689011686 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1048689011687 carboxylesterase BioH; Provisional; Region: PRK10349 1048689011688 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1048689011689 DNA utilization protein GntX; Provisional; Region: PRK11595 1048689011690 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1048689011691 active site 1048689011692 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 1048689011693 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1048689011694 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1048689011695 high-affinity gluconate transporter; Provisional; Region: PRK14984 1048689011696 gluconate transporter; Region: gntP; TIGR00791 1048689011697 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1048689011698 4-alpha-glucanotransferase; Region: malQ; TIGR00217 1048689011699 maltodextrin phosphorylase; Provisional; Region: PRK14985 1048689011700 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1048689011701 homodimer interface [polypeptide binding]; other site 1048689011702 active site pocket [active] 1048689011703 transcriptional regulator MalT; Provisional; Region: PRK04841 1048689011704 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1048689011705 DNA binding residues [nucleotide binding] 1048689011706 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 1048689011707 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1048689011708 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 1048689011709 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 1048689011710 putative active site [active] 1048689011711 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 1048689011712 hypothetical protein; Reviewed; Region: PRK09588 1048689011713 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 1048689011714 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 1048689011715 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1048689011716 Walker A motif; other site 1048689011717 ATP binding site [chemical binding]; other site 1048689011718 Walker B motif; other site 1048689011719 arginine finger; other site 1048689011720 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 1048689011721 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1048689011722 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1048689011723 intramembrane serine protease GlpG; Provisional; Region: PRK10907 1048689011724 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 1048689011725 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1048689011726 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 1048689011727 active site residue [active] 1048689011728 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 1048689011729 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 1048689011730 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 1048689011731 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 1048689011732 glycogen phosphorylase; Provisional; Region: PRK14986 1048689011733 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1048689011734 homodimer interface [polypeptide binding]; other site 1048689011735 active site pocket [active] 1048689011736 glycogen synthase; Provisional; Region: glgA; PRK00654 1048689011737 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1048689011738 ADP-binding pocket [chemical binding]; other site 1048689011739 homodimer interface [polypeptide binding]; other site 1048689011740 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 1048689011741 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1048689011742 ligand binding site; other site 1048689011743 oligomer interface; other site 1048689011744 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1048689011745 sulfate 1 binding site; other site 1048689011746 glycogen debranching enzyme; Provisional; Region: PRK03705 1048689011747 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1048689011748 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1048689011749 active site 1048689011750 catalytic site [active] 1048689011751 glycogen branching enzyme; Provisional; Region: PRK05402 1048689011752 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1048689011753 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1048689011754 active site 1048689011755 catalytic site [active] 1048689011756 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1048689011757 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 1048689011758 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1048689011759 putative antibiotic transporter; Provisional; Region: PRK10739 1048689011760 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 1048689011761 DNA protecting protein DprA; Region: dprA; TIGR00732 1048689011762 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1048689011763 non-specific DNA interactions [nucleotide binding]; other site 1048689011764 DNA binding site [nucleotide binding] 1048689011765 sequence specific DNA binding site [nucleotide binding]; other site 1048689011766 putative cAMP binding site [chemical binding]; other site 1048689011767 potential frameshift: common BLAST hit: gi|110643677|ref|YP_671407.1| DNA helicase 1048689011768 potential frameshift: common BLAST hit: gi|260846221|ref|YP_003223999.1| putative ATP-dependent DNA helicase 1048689011769 low affinity gluconate transporter; Provisional; Region: PRK10472 1048689011770 gluconate transporter; Region: gntP; TIGR00791 1048689011771 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1048689011772 ATP-binding site [chemical binding]; other site 1048689011773 Gluconate-6-phosphate binding site [chemical binding]; other site 1048689011774 Shikimate kinase; Region: SKI; pfam01202 1048689011775 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 1048689011776 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1048689011777 DNA binding site [nucleotide binding] 1048689011778 domain linker motif; other site 1048689011779 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1048689011780 putative ligand binding site [chemical binding]; other site 1048689011781 putative dimerization interface [polypeptide binding]; other site 1048689011782 Pirin-related protein [General function prediction only]; Region: COG1741 1048689011783 Pirin; Region: Pirin; pfam02678 1048689011784 putative oxidoreductase; Provisional; Region: PRK10206 1048689011785 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1048689011786 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1048689011787 putative acetyltransferase YhhY; Provisional; Region: PRK10140 1048689011788 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1048689011789 Coenzyme A binding pocket [chemical binding]; other site 1048689011790 Protein of unknown function (DUF4225); Region: DUF4225; pfam13988 1048689011791 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 1048689011792 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 1048689011793 hypothetical protein; Provisional; Region: PRK10350 1048689011794 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 1048689011795 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 1048689011796 putative active site [active] 1048689011797 catalytic site [active] 1048689011798 putative metal binding site [ion binding]; other site 1048689011799 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1048689011800 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1048689011801 Walker A/P-loop; other site 1048689011802 ATP binding site [chemical binding]; other site 1048689011803 Q-loop/lid; other site 1048689011804 ABC transporter signature motif; other site 1048689011805 Walker B; other site 1048689011806 D-loop; other site 1048689011807 H-loop/switch region; other site 1048689011808 TOBE domain; Region: TOBE_2; pfam08402 1048689011809 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1048689011810 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048689011811 dimer interface [polypeptide binding]; other site 1048689011812 conserved gate region; other site 1048689011813 putative PBP binding loops; other site 1048689011814 ABC-ATPase subunit interface; other site 1048689011815 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1048689011816 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048689011817 dimer interface [polypeptide binding]; other site 1048689011818 conserved gate region; other site 1048689011819 putative PBP binding loops; other site 1048689011820 ABC-ATPase subunit interface; other site 1048689011821 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 1048689011822 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1048689011823 Uncharacterized protein conserved in bacteria containing a divergent form of TPR repeats [Function unknown]; Region: COG4700 1048689011824 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1048689011825 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1048689011826 binding surface 1048689011827 TPR motif; other site 1048689011828 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 1048689011829 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1048689011830 Walker A/P-loop; other site 1048689011831 ATP binding site [chemical binding]; other site 1048689011832 Q-loop/lid; other site 1048689011833 ABC transporter signature motif; other site 1048689011834 Walker B; other site 1048689011835 D-loop; other site 1048689011836 H-loop/switch region; other site 1048689011837 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 1048689011838 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1048689011839 Walker A/P-loop; other site 1048689011840 ATP binding site [chemical binding]; other site 1048689011841 Q-loop/lid; other site 1048689011842 ABC transporter signature motif; other site 1048689011843 Walker B; other site 1048689011844 D-loop; other site 1048689011845 H-loop/switch region; other site 1048689011846 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 1048689011847 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 1048689011848 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1048689011849 TM-ABC transporter signature motif; other site 1048689011850 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1048689011851 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1048689011852 TM-ABC transporter signature motif; other site 1048689011853 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1048689011854 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1048689011855 dimerization interface [polypeptide binding]; other site 1048689011856 ligand binding site [chemical binding]; other site 1048689011857 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 1048689011858 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1048689011859 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 1048689011860 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1048689011861 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1048689011862 dimerization interface [polypeptide binding]; other site 1048689011863 ligand binding site [chemical binding]; other site 1048689011864 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 1048689011865 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1048689011866 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1048689011867 DNA binding residues [nucleotide binding] 1048689011868 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1048689011869 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 1048689011870 cell division protein FtsE; Provisional; Region: PRK10908 1048689011871 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1048689011872 Walker A/P-loop; other site 1048689011873 ATP binding site [chemical binding]; other site 1048689011874 Q-loop/lid; other site 1048689011875 ABC transporter signature motif; other site 1048689011876 Walker B; other site 1048689011877 D-loop; other site 1048689011878 H-loop/switch region; other site 1048689011879 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1048689011880 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1048689011881 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1048689011882 P loop; other site 1048689011883 GTP binding site [chemical binding]; other site 1048689011884 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1048689011885 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1048689011886 S-adenosylmethionine binding site [chemical binding]; other site 1048689011887 hypothetical protein; Provisional; Region: PRK10910 1048689011888 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 1048689011889 Predicted membrane protein [Function unknown]; Region: COG3714 1048689011890 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 1048689011891 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1048689011892 metal-binding site [ion binding] 1048689011893 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1048689011894 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 1048689011895 CPxP motif; other site 1048689011896 hypothetical protein; Provisional; Region: PRK11212 1048689011897 hypothetical protein; Provisional; Region: PRK11615 1048689011898 major facilitator superfamily transporter; Provisional; Region: PRK05122 1048689011899 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689011900 putative substrate translocation pore; other site 1048689011901 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1048689011902 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1048689011903 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 1048689011904 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1048689011905 S-adenosylmethionine binding site [chemical binding]; other site 1048689011906 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 1048689011907 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1048689011908 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1048689011909 putative acyl-acceptor binding pocket; other site 1048689011910 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1048689011911 acyl carrier protein; Provisional; Region: PRK05350 1048689011912 Predicted membrane protein [Function unknown]; Region: COG4648 1048689011913 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1048689011914 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1048689011915 acyl-activating enzyme (AAE) consensus motif; other site 1048689011916 active site 1048689011917 AMP binding site [chemical binding]; other site 1048689011918 CoA binding site [chemical binding]; other site 1048689011919 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases [Lipid metabolism]; Region: FabA; COG0764 1048689011920 active site 2 [active] 1048689011921 active site 1 [active] 1048689011922 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1048689011923 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1048689011924 Ligand binding site; other site 1048689011925 Putative Catalytic site; other site 1048689011926 DXD motif; other site 1048689011927 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1048689011928 putative acyl-acceptor binding pocket; other site 1048689011929 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1048689011930 active site 1048689011931 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 1048689011932 Predicted exporter [General function prediction only]; Region: COG4258 1048689011933 Protein of unknown function (DUF3261); Region: DUF3261; pfam11659 1048689011934 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 1048689011935 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1048689011936 dimer interface [polypeptide binding]; other site 1048689011937 active site 1048689011938 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 1048689011939 putative active site 1 [active] 1048689011940 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1048689011941 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 1048689011942 NAD(P) binding site [chemical binding]; other site 1048689011943 active site 1048689011944 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 1048689011945 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1048689011946 dimer interface [polypeptide binding]; other site 1048689011947 active site 1048689011948 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 1048689011949 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1048689011950 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1048689011951 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 1048689011952 substrate binding site [chemical binding]; other site 1048689011953 nickel transporter permease NikB; Provisional; Region: PRK10352 1048689011954 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048689011955 dimer interface [polypeptide binding]; other site 1048689011956 conserved gate region; other site 1048689011957 putative PBP binding loops; other site 1048689011958 ABC-ATPase subunit interface; other site 1048689011959 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 1048689011960 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048689011961 dimer interface [polypeptide binding]; other site 1048689011962 conserved gate region; other site 1048689011963 putative PBP binding loops; other site 1048689011964 ABC-ATPase subunit interface; other site 1048689011965 nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418 1048689011966 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1048689011967 Walker A/P-loop; other site 1048689011968 ATP binding site [chemical binding]; other site 1048689011969 Q-loop/lid; other site 1048689011970 ABC transporter signature motif; other site 1048689011971 Walker B; other site 1048689011972 D-loop; other site 1048689011973 H-loop/switch region; other site 1048689011974 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1048689011975 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 1048689011976 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1048689011977 Walker A/P-loop; other site 1048689011978 ATP binding site [chemical binding]; other site 1048689011979 Q-loop/lid; other site 1048689011980 ABC transporter signature motif; other site 1048689011981 Walker B; other site 1048689011982 D-loop; other site 1048689011983 H-loop/switch region; other site 1048689011984 nickel responsive regulator; Provisional; Region: PRK02967 1048689011985 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 1048689011986 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1048689011987 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1048689011988 DNA-binding site [nucleotide binding]; DNA binding site 1048689011989 UTRA domain; Region: UTRA; pfam07702 1048689011990 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1048689011991 active site 1048689011992 phosphorylation site [posttranslational modification] 1048689011993 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1048689011994 active site 1048689011995 P-loop; other site 1048689011996 phosphorylation site [posttranslational modification] 1048689011997 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 1048689011998 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1048689011999 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1048689012000 uncharacterized subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_1; cd07774 1048689012001 putative N- and C-terminal domain interface [polypeptide binding]; other site 1048689012002 putative active site [active] 1048689012003 putative MgATP binding site [chemical binding]; other site 1048689012004 catalytic site [active] 1048689012005 metal binding site [ion binding]; metal-binding site 1048689012006 putative carbohydrate binding site [chemical binding]; other site 1048689012007 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1048689012008 dimerization domain swap beta strand [polypeptide binding]; other site 1048689012009 regulatory protein interface [polypeptide binding]; other site 1048689012010 active site 1048689012011 regulatory phosphorylation site [posttranslational modification]; other site 1048689012012 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1048689012013 intersubunit interface [polypeptide binding]; other site 1048689012014 active site 1048689012015 zinc binding site [ion binding]; other site 1048689012016 Na+ binding site [ion binding]; other site 1048689012017 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 1048689012018 HicB family; Region: HicB; pfam05534 1048689012019 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1048689012020 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1048689012021 potential frameshift: common BLAST hit: gi|254795429|ref|YP_003080266.1| fused ribosome-associated ATPase: ATP-binding protein, ATP-binding 1048689012022 HlyD family secretion protein; Region: HlyD; pfam00529 1048689012023 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1048689012024 HlyD family secretion protein; Region: HlyD_3; pfam13437 1048689012025 Domain of unknown function (DUF4049); Region: DUF4049; pfam13258 1048689012026 Domain of unknown function (DUF4049); Region: DUF4049; pfam13258 1048689012027 Protein of unknown function (DUF2776); Region: DUF2776; pfam10951 1048689012028 Predicted flavoproteins [General function prediction only]; Region: COG2081 1048689012029 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1048689012030 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1048689012031 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1048689012032 universal stress protein UspB; Provisional; Region: PRK04960 1048689012033 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1048689012034 Ligand Binding Site [chemical binding]; other site 1048689012035 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 1048689012036 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689012037 POT family; Region: PTR2; pfam00854 1048689012038 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1048689012039 S-adenosylmethionine binding site [chemical binding]; other site 1048689012040 oligopeptidase A; Provisional; Region: PRK10911 1048689012041 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1048689012042 active site 1048689012043 Zn binding site [ion binding]; other site 1048689012044 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 1048689012045 glutathione reductase; Validated; Region: PRK06116 1048689012046 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1048689012047 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1048689012048 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1048689012049 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1048689012050 dimerization interface [polypeptide binding]; other site 1048689012051 putative DNA binding site [nucleotide binding]; other site 1048689012052 putative Zn2+ binding site [ion binding]; other site 1048689012053 arsenical pump membrane protein; Provisional; Region: PRK15445 1048689012054 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1048689012055 transmembrane helices; other site 1048689012056 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1048689012057 ArsC family; Region: ArsC; pfam03960 1048689012058 catalytic residues [active] 1048689012059 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 1048689012060 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1048689012061 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1048689012062 DNA binding residues [nucleotide binding] 1048689012063 dimerization interface [polypeptide binding]; other site 1048689012064 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 1048689012065 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 1048689012066 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 1048689012067 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 1048689012068 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1048689012069 N-terminal plug; other site 1048689012070 ligand-binding site [chemical binding]; other site 1048689012071 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 1048689012072 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 1048689012073 putative hemin binding site; other site 1048689012074 coproporphyrinogen III oxidase; Provisional; Region: PRK09058 1048689012075 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1048689012076 FeS/SAM binding site; other site 1048689012077 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugX; COG3721 1048689012078 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1048689012079 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1048689012080 NAD(P) binding site [chemical binding]; other site 1048689012081 putative active site [active] 1048689012082 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1048689012083 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1048689012084 ABC-ATPase subunit interface; other site 1048689012085 dimer interface [polypeptide binding]; other site 1048689012086 putative PBP binding regions; other site 1048689012087 ABC-type hemin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG4559 1048689012088 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1048689012089 Walker A/P-loop; other site 1048689012090 ATP binding site [chemical binding]; other site 1048689012091 Q-loop/lid; other site 1048689012092 ABC transporter signature motif; other site 1048689012093 Walker B; other site 1048689012094 D-loop; other site 1048689012095 H-loop/switch region; other site 1048689012096 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 1048689012097 MgtC family; Region: MgtC; pfam02308 1048689012098 acid-resistance protein; Provisional; Region: hdeB; PRK11566 1048689012099 acid-resistance protein; Provisional; Region: PRK10208 1048689012100 acid-resistance membrane protein; Provisional; Region: PRK10209 1048689012101 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1048689012102 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1048689012103 pyruvate kinase; Provisional; Region: PRK05826 1048689012104 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 1048689012105 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1048689012106 HlyD family secretion protein; Region: HlyD_3; pfam13437 1048689012107 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 1048689012108 Protein export membrane protein; Region: SecD_SecF; cl14618 1048689012109 transcriptional regulator YdeO; Provisional; Region: PRK09940 1048689012110 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1048689012111 DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978 1048689012112 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1048689012113 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1048689012114 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048689012115 catalytic residue [active] 1048689012116 Haem-binding domain; Region: Haem_bd; pfam14376 1048689012117 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 1048689012118 trehalase; Provisional; Region: treF; PRK13270 1048689012119 Trehalase; Region: Trehalase; pfam01204 1048689012120 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1048689012121 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1048689012122 DNA binding residues [nucleotide binding] 1048689012123 dimerization interface [polypeptide binding]; other site 1048689012124 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1048689012125 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1048689012126 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1048689012127 putative effector binding pocket; other site 1048689012128 putative dimerization interface [polypeptide binding]; other site 1048689012129 inner membrane protein YhjD; Region: TIGR00766 1048689012130 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689012131 metabolite-proton symporter; Region: 2A0106; TIGR00883 1048689012132 putative substrate translocation pore; other site 1048689012133 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 1048689012134 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1048689012135 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1048689012136 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1048689012137 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1048689012138 substrate binding site [chemical binding]; other site 1048689012139 ATP binding site [chemical binding]; other site 1048689012140 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1048689012141 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1048689012142 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1048689012143 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1048689012144 putative diguanylate cyclase; Provisional; Region: PRK13561 1048689012145 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1048689012146 metal binding site [ion binding]; metal-binding site 1048689012147 active site 1048689012148 I-site; other site 1048689012149 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1048689012150 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 1048689012151 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1048689012152 binding surface 1048689012153 TPR motif; other site 1048689012154 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 1048689012155 endo-1,4-D-glucanase; Provisional; Region: PRK11097 1048689012156 cellulose synthase regulator protein; Provisional; Region: PRK11114 1048689012157 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 1048689012158 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1048689012159 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 1048689012160 DXD motif; other site 1048689012161 PilZ domain; Region: PilZ; pfam07238 1048689012162 cell division protein; Provisional; Region: PRK10037 1048689012163 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 1048689012164 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 1048689012165 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 1048689012166 celllulose biosynthesis operon protein BcsF/YhjT; Region: cellullose_BcsF; TIGR03493 1048689012167 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 1048689012168 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 1048689012169 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1048689012170 serine transporter; Region: stp; TIGR00814 1048689012171 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1048689012172 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1048689012173 Walker A/P-loop; other site 1048689012174 ATP binding site [chemical binding]; other site 1048689012175 Q-loop/lid; other site 1048689012176 ABC transporter signature motif; other site 1048689012177 Walker B; other site 1048689012178 D-loop; other site 1048689012179 H-loop/switch region; other site 1048689012180 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1048689012181 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 1048689012182 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1048689012183 Walker A/P-loop; other site 1048689012184 ATP binding site [chemical binding]; other site 1048689012185 Q-loop/lid; other site 1048689012186 ABC transporter signature motif; other site 1048689012187 Walker B; other site 1048689012188 D-loop; other site 1048689012189 H-loop/switch region; other site 1048689012190 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1048689012191 dipeptide transporter; Provisional; Region: PRK10913 1048689012192 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1048689012193 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048689012194 dimer interface [polypeptide binding]; other site 1048689012195 conserved gate region; other site 1048689012196 putative PBP binding loops; other site 1048689012197 ABC-ATPase subunit interface; other site 1048689012198 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1048689012199 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048689012200 dimer interface [polypeptide binding]; other site 1048689012201 conserved gate region; other site 1048689012202 putative PBP binding loops; other site 1048689012203 ABC-ATPase subunit interface; other site 1048689012204 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1048689012205 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1048689012206 peptide binding site [polypeptide binding]; other site 1048689012207 phosphoethanolamine transferase; Provisional; Region: PRK11560 1048689012208 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1048689012209 Sulfatase; Region: Sulfatase; pfam00884 1048689012210 long polar fimbrial protein LpfE; Provisional; Region: PRK15205 1048689012211 Fimbrial protein; Region: Fimbrial; cl01416 1048689012212 long polar fimbrial outer membrane usher protein LpfC; Provisional; Region: PRK15207 1048689012213 PapC N-terminal domain; Region: PapC_N; pfam13954 1048689012214 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1048689012215 PapC C-terminal domain; Region: PapC_C; pfam13953 1048689012216 long polar fimbrial chaperone LpfB; Provisional; Region: PRK15208 1048689012217 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1048689012218 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1048689012219 long polar fimbrial protein LpfA; Provisional; Region: PRK15209 1048689012220 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 1048689012221 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689012222 putative substrate translocation pore; other site 1048689012223 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 1048689012224 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 1048689012225 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1048689012226 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1048689012227 Coenzyme A binding pocket [chemical binding]; other site 1048689012228 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1048689012229 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 1048689012230 molybdopterin cofactor binding site [chemical binding]; other site 1048689012231 substrate binding site [chemical binding]; other site 1048689012232 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 1048689012233 molybdopterin cofactor binding site; other site 1048689012234 putative outer membrane lipoprotein; Provisional; Region: PRK10510 1048689012235 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1048689012236 ligand binding site [chemical binding]; other site 1048689012237 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 1048689012238 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1048689012239 dimerization interface [polypeptide binding]; other site 1048689012240 ligand binding site [chemical binding]; other site 1048689012241 NADP binding site [chemical binding]; other site 1048689012242 catalytic site [active] 1048689012243 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 1048689012244 Predicted transcriptional regulator [Transcription]; Region: COG2944 1048689012245 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1048689012246 non-specific DNA binding site [nucleotide binding]; other site 1048689012247 salt bridge; other site 1048689012248 sequence-specific DNA binding site [nucleotide binding]; other site 1048689012249 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1048689012250 DNA-binding site [nucleotide binding]; DNA binding site 1048689012251 RNA-binding motif; other site 1048689012252 small toxic polypeptide; Provisional; Region: PRK09759 1048689012253 glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211 1048689012254 DALR anticodon binding domain; Region: DALR_1; pfam05746 1048689012255 anticodon binding site; other site 1048689012256 tRNA binding surface [nucleotide binding]; other site 1048689012257 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1048689012258 dimer interface [polypeptide binding]; other site 1048689012259 motif 1; other site 1048689012260 active site 1048689012261 motif 2; other site 1048689012262 motif 3; other site 1048689012263 YsaB-like lipoprotein; Region: YsaB; pfam13983 1048689012264 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 1048689012265 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1048689012266 hypothetical protein; Provisional; Region: PRK11383 1048689012267 yiaA/B two helix domain; Region: YiaAB; pfam05360 1048689012268 yiaA/B two helix domain; Region: YiaAB; pfam05360 1048689012269 hypothetical protein; Provisional; Region: PRK11403 1048689012270 yiaA/B two helix domain; Region: YiaAB; pfam05360 1048689012271 xylulokinase; Provisional; Region: PRK15027 1048689012272 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1048689012273 N- and C-terminal domain interface [polypeptide binding]; other site 1048689012274 active site 1048689012275 MgATP binding site [chemical binding]; other site 1048689012276 catalytic site [active] 1048689012277 metal binding site [ion binding]; metal-binding site 1048689012278 xylulose binding site [chemical binding]; other site 1048689012279 homodimer interface [polypeptide binding]; other site 1048689012280 xylose isomerase; Provisional; Region: PRK05474 1048689012281 xylose isomerase; Region: xylose_isom_A; TIGR02630 1048689012282 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 1048689012283 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 1048689012284 putative ligand binding site [chemical binding]; other site 1048689012285 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 1048689012286 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1048689012287 Walker A/P-loop; other site 1048689012288 ATP binding site [chemical binding]; other site 1048689012289 Q-loop/lid; other site 1048689012290 ABC transporter signature motif; other site 1048689012291 Walker B; other site 1048689012292 D-loop; other site 1048689012293 H-loop/switch region; other site 1048689012294 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1048689012295 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1048689012296 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1048689012297 TM-ABC transporter signature motif; other site 1048689012298 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 1048689012299 putative dimerization interface [polypeptide binding]; other site 1048689012300 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1048689012301 putative ligand binding site [chemical binding]; other site 1048689012302 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1048689012303 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1048689012304 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1048689012305 hypothetical protein; Provisional; Region: PRK10356 1048689012306 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 1048689012307 alpha-amylase; Reviewed; Region: malS; PRK09505 1048689012308 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1048689012309 active site 1048689012310 catalytic site [active] 1048689012311 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 1048689012312 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1048689012313 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048689012314 homodimer interface [polypeptide binding]; other site 1048689012315 catalytic residue [active] 1048689012316 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 1048689012317 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1048689012318 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1048689012319 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1048689012320 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1048689012321 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1048689012322 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1048689012323 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 1048689012324 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 1048689012325 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 1048689012326 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1048689012327 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1048689012328 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1048689012329 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1048689012330 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1048689012331 HlyD family secretion protein; Region: HlyD_3; pfam13437 1048689012332 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 1048689012333 FlxA-like protein; Region: FlxA; pfam14282 1048689012334 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 1048689012335 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1048689012336 NAD(P) binding site [chemical binding]; other site 1048689012337 catalytic residues [active] 1048689012338 Fic family protein [Function unknown]; Region: COG3177 1048689012339 Fic/DOC family; Region: Fic; pfam02661 1048689012340 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1048689012341 putative alcohol dehydrogenase; Provisional; Region: PRK09860 1048689012342 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 1048689012343 dimer interface [polypeptide binding]; other site 1048689012344 active site 1048689012345 metal binding site [ion binding]; metal-binding site 1048689012346 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 1048689012347 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 1048689012348 G1 box; other site 1048689012349 putative GEF interaction site [polypeptide binding]; other site 1048689012350 GTP/Mg2+ binding site [chemical binding]; other site 1048689012351 Switch I region; other site 1048689012352 G2 box; other site 1048689012353 G3 box; other site 1048689012354 Switch II region; other site 1048689012355 G4 box; other site 1048689012356 G5 box; other site 1048689012357 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 1048689012358 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 1048689012359 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 1048689012360 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 1048689012361 selenocysteine synthase; Provisional; Region: PRK04311 1048689012362 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 1048689012363 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 1048689012364 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1048689012365 catalytic residue [active] 1048689012366 putative glutathione S-transferase; Provisional; Region: PRK10357 1048689012367 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 1048689012368 putative C-terminal domain interface [polypeptide binding]; other site 1048689012369 putative GSH binding site (G-site) [chemical binding]; other site 1048689012370 putative dimer interface [polypeptide binding]; other site 1048689012371 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 1048689012372 dimer interface [polypeptide binding]; other site 1048689012373 N-terminal domain interface [polypeptide binding]; other site 1048689012374 putative substrate binding pocket (H-site) [chemical binding]; other site 1048689012375 PAAR motif; Region: PAAR_motif; cl15808 1048689012376 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1048689012377 RHS Repeat; Region: RHS_repeat; pfam05593 1048689012378 RHS Repeat; Region: RHS_repeat; pfam05593 1048689012379 RHS Repeat; Region: RHS_repeat; pfam05593 1048689012380 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1048689012381 RHS Repeat; Region: RHS_repeat; pfam05593 1048689012382 RHS Repeat; Region: RHS_repeat; pfam05593 1048689012383 RHS protein; Region: RHS; pfam03527 1048689012384 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1048689012385 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1048689012386 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1048689012387 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1048689012388 HlyD family secretion protein; Region: HlyD_3; pfam13437 1048689012389 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 1048689012390 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 1048689012391 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1048689012392 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1048689012393 active site 1048689012394 P-loop; other site 1048689012395 phosphorylation site [posttranslational modification] 1048689012396 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1048689012397 active site 1048689012398 phosphorylation site [posttranslational modification] 1048689012399 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 1048689012400 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1048689012401 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1048689012402 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 1048689012403 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 1048689012404 hypothetical protein; Provisional; Region: PRK11020 1048689012405 Protein of unknown function (DUF3251); Region: DUF3251; cl08186 1048689012406 potential frameshift: common BLAST hit: gi|254795560|ref|YP_003080397.1| putative adhesin 1048689012407 L-lactate permease; Provisional; Region: PRK10420 1048689012408 glycolate transporter; Provisional; Region: PRK09695 1048689012409 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 1048689012410 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1048689012411 DNA-binding site [nucleotide binding]; DNA binding site 1048689012412 FCD domain; Region: FCD; pfam07729 1048689012413 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 1048689012414 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1048689012415 phosphate binding site [ion binding]; other site 1048689012416 putative rRNA methylase; Provisional; Region: PRK10358 1048689012417 serine acetyltransferase; Provisional; Region: cysE; PRK11132 1048689012418 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 1048689012419 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1048689012420 trimer interface [polypeptide binding]; other site 1048689012421 active site 1048689012422 substrate binding site [chemical binding]; other site 1048689012423 CoA binding site [chemical binding]; other site 1048689012424 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1048689012425 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1048689012426 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1048689012427 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 1048689012428 SecA binding site; other site 1048689012429 Preprotein binding site; other site 1048689012430 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 1048689012431 GSH binding site [chemical binding]; other site 1048689012432 catalytic residues [active] 1048689012433 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1048689012434 active site residue [active] 1048689012435 phosphoglyceromutase; Provisional; Region: PRK05434 1048689012436 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 1048689012437 AmiB activator; Provisional; Region: PRK11637 1048689012438 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 1048689012439 Peptidase family M23; Region: Peptidase_M23; pfam01551 1048689012440 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 1048689012441 NodB motif; other site 1048689012442 putative active site [active] 1048689012443 putative catalytic site [active] 1048689012444 Zn binding site [ion binding]; other site 1048689012445 putative glycosyl transferase; Provisional; Region: PRK10073 1048689012446 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1048689012447 active site 1048689012448 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 1048689012449 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1048689012450 NAD(P) binding site [chemical binding]; other site 1048689012451 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1048689012452 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1048689012453 substrate-cofactor binding pocket; other site 1048689012454 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048689012455 catalytic residue [active] 1048689012456 hypothetical protein; Provisional; Region: PRK11346 1048689012457 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 1048689012458 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 1048689012459 NADP binding site [chemical binding]; other site 1048689012460 homopentamer interface [polypeptide binding]; other site 1048689012461 substrate binding site [chemical binding]; other site 1048689012462 active site 1048689012463 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1048689012464 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1048689012465 putative active site [active] 1048689012466 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1048689012467 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1048689012468 putative active site [active] 1048689012469 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1048689012470 O-antigen ligase RfaL; Provisional; Region: PRK15487 1048689012471 lipopolysaccharide 1,2-N-acetylglucosaminetransferase; Provisional; Region: PRK15484 1048689012472 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1048689012473 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1048689012474 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 1048689012475 Ligand binding site; other site 1048689012476 metal-binding site 1048689012477 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 1048689012478 Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; cl17526 1048689012479 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 1048689012480 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1048689012481 Ligand binding site; other site 1048689012482 metal-binding site 1048689012483 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 1048689012484 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 1048689012485 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1048689012486 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1048689012487 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 1048689012488 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1048689012489 putative active site [active] 1048689012490 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 1048689012491 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 1048689012492 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1048689012493 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1048689012494 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1048689012495 active site 1048689012496 (T/H)XGH motif; other site 1048689012497 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1048689012498 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1048689012499 DNA binding site [nucleotide binding] 1048689012500 catalytic residue [active] 1048689012501 H2TH interface [polypeptide binding]; other site 1048689012502 putative catalytic residues [active] 1048689012503 turnover-facilitating residue; other site 1048689012504 intercalation triad [nucleotide binding]; other site 1048689012505 8OG recognition residue [nucleotide binding]; other site 1048689012506 putative reading head residues; other site 1048689012507 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1048689012508 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1048689012509 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1048689012510 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1048689012511 hypothetical protein; Reviewed; Region: PRK00024 1048689012512 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1048689012513 MPN+ (JAMM) motif; other site 1048689012514 Zinc-binding site [ion binding]; other site 1048689012515 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1048689012516 Flavoprotein; Region: Flavoprotein; pfam02441 1048689012517 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1048689012518 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1048689012519 trimer interface [polypeptide binding]; other site 1048689012520 active site 1048689012521 division inhibitor protein; Provisional; Region: slmA; PRK09480 1048689012522 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1048689012523 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1048689012524 active site 1048689012525 ribonuclease PH; Reviewed; Region: rph; PRK00173 1048689012526 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1048689012527 hexamer interface [polypeptide binding]; other site 1048689012528 active site 1048689012529 hypothetical protein; Provisional; Region: PRK11820 1048689012530 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1048689012531 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1048689012532 DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525 1048689012533 BRO family, N-terminal domain; Region: Bro-N; pfam02498 1048689012534 Predicted membrane protein [Function unknown]; Region: COG2860 1048689012535 UPF0126 domain; Region: UPF0126; pfam03458 1048689012536 UPF0126 domain; Region: UPF0126; pfam03458 1048689012537 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 1048689012538 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 1048689012539 nucleotide binding pocket [chemical binding]; other site 1048689012540 K-X-D-G motif; other site 1048689012541 catalytic site [active] 1048689012542 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1048689012543 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1048689012544 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1048689012545 catalytic site [active] 1048689012546 G-X2-G-X-G-K; other site 1048689012547 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 1048689012548 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 1048689012549 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1048689012550 Zn2+ binding site [ion binding]; other site 1048689012551 Mg2+ binding site [ion binding]; other site 1048689012552 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1048689012553 synthetase active site [active] 1048689012554 NTP binding site [chemical binding]; other site 1048689012555 metal binding site [ion binding]; metal-binding site 1048689012556 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1048689012557 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1048689012558 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 1048689012559 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1048689012560 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 1048689012561 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1048689012562 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1048689012563 generic binding surface II; other site 1048689012564 ssDNA binding site; other site 1048689012565 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1048689012566 ATP binding site [chemical binding]; other site 1048689012567 putative Mg++ binding site [ion binding]; other site 1048689012568 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1048689012569 nucleotide binding region [chemical binding]; other site 1048689012570 ATP-binding site [chemical binding]; other site 1048689012571 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 1048689012572 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 1048689012573 AsmA family; Region: AsmA; pfam05170 1048689012574 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1048689012575 putative alpha-glucosidase; Provisional; Region: PRK10658 1048689012576 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1048689012577 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 1048689012578 active site 1048689012579 homotrimer interface [polypeptide binding]; other site 1048689012580 catalytic site [active] 1048689012581 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 1048689012582 putative transporter; Provisional; Region: PRK11462 1048689012583 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1048689012584 phage-like element CpLE3; locus of enterocyte effacement 1048689012585 integrase; Provisional; Region: PRK09692 1048689012586 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1048689012587 active site 1048689012588 Int/Topo IB signature motif; other site 1048689012589 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1048689012590 Transposase; Region: HTH_Tnp_1; cl17663 1048689012591 HTH-like domain; Region: HTH_21; pfam13276 1048689012592 Integrase core domain; Region: rve; pfam00665 1048689012593 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1048689012594 Integrase core domain; Region: rve_3; pfam13683 1048689012595 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 1048689012596 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 1048689012597 Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117 1048689012598 Methyltransferase domain; Region: Methyltransf_27; pfam13708 1048689012599 Methyltransferase domain; Region: Methyltransf_27; pfam13708 1048689012600 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 1048689012601 type III secretion system protein, SsaH family; Region: type_III_ssaH; TIGR02498 1048689012602 type III secretion apparatus needle protein; Region: III_needle; TIGR02105 1048689012603 pathogenicity island 2 effector protein SseE; Provisional; Region: PRK15360 1048689012604 Enterobacterial EspB protein; Region: EspB; pfam05802 1048689012605 Uncharacterized conserved protein [Function unknown]; Region: COG5613 1048689012606 EspA-like secreted protein; Region: EspA; pfam03433 1048689012607 HrpJ-like domain; Region: HrpJ; pfam07201 1048689012608 type III secretion effector delivery regulator, TyeA family; Region: type_III_tyeA; TIGR02511 1048689012609 type III secretion system protein SsaD; Provisional; Region: PRK15367 1048689012610 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 1048689012611 LysM domain; Region: LysM; pfam01476 1048689012612 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 1048689012613 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 1048689012614 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1048689012615 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 1048689012616 Intimin C-type lectin domain; Region: Intimin_C; pfam07979 1048689012617 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 1048689012618 Translocated intimin receptor (Tir) N-terminus; Region: Tir_receptor_N; pfam07490 1048689012619 Translocated intimin receptor (Tir) intimin-binding domain; Region: Tir_receptor_M; pfam03549 1048689012620 Translocated intimin receptor (Tir) C-terminus; Region: Tir_receptor_C; pfam07489 1048689012621 IpaB/EvcA family; Region: IpaB_EvcA; pfam03278 1048689012622 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 1048689012623 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 1048689012624 type III secretion apparatus H+-transporting two-sector ATPase; Region: III_secr_ATP; TIGR02546 1048689012625 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1048689012626 Walker A motif/ATP binding site; other site 1048689012627 Walker B motif; other site 1048689012628 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 1048689012629 FHIPEP family; Region: FHIPEP; pfam00771 1048689012630 SepZ; Region: SepZ; pfam06066 1048689012631 Type III secretory pathway, lipoprotein EscJ [Intracellular trafficking and secretion]; Region: EscJ; COG4669 1048689012632 outer membrane secretin SsaC; Provisional; Region: PRK15346 1048689012633 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1048689012634 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1048689012635 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 1048689012636 Tetratricopeptide repeat; Region: TPR_3; pfam07720 1048689012637 Protein of unknown function (DUF1401); Region: DUF1401; pfam07180 1048689012638 negative regulator GrlR; Provisional; Region: PRK14051 1048689012639 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1048689012640 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1048689012641 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1048689012642 catalytic residue [active] 1048689012643 secretion system apparatus protein SsaU; Reviewed; Region: PRK12721 1048689012644 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 1048689012645 type III secretion protein SpaR/YscT/HrcT; Region: fliR_like_III; TIGR01401 1048689012646 Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794 1048689012647 Type III secretory pathway, component EscR [Intracellular trafficking and secretion]; Region: EscR; COG4790 1048689012648 Type III secretion system subunit; Region: T3SS_LEE_assoc; pfam13327 1048689012649 Type III secretion system filament chaperone CesA; Region: CesA; pfam11439 1048689012650 type III secretion system protein, YseE family; Region: type_III_yscE; TIGR02501 1048689012651 DNA-binding protein H-NS [General function prediction only]; Region: Hns; COG2916 1048689012652 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 1048689012653 EspG protein; Region: EspG; pfam06872 1048689012654 SdiA-regulated; Region: SdiA-regulated; cd09971 1048689012655 SdiA-regulated; Region: SdiA-regulated; pfam06977 1048689012656 putative active site [active] 1048689012657 EamA-like transporter family; Region: EamA; pfam00892 1048689012658 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1048689012659 EamA-like transporter family; Region: EamA; pfam00892 1048689012660 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 1048689012661 lipoprotein, YaeC family; Region: TIGR00363 1048689012662 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 1048689012663 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689012664 putative substrate translocation pore; other site 1048689012665 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4737 1048689012666 Predicted transcriptional regulator [Transcription]; Region: COG2944 1048689012667 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1048689012668 non-specific DNA binding site [nucleotide binding]; other site 1048689012669 salt bridge; other site 1048689012670 sequence-specific DNA binding site [nucleotide binding]; other site 1048689012671 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 1048689012672 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1048689012673 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1048689012674 cryptic adenine deaminase; Provisional; Region: PRK10027 1048689012675 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1048689012676 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1048689012677 active site 1048689012678 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 1048689012679 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 1048689012680 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689012681 putative substrate translocation pore; other site 1048689012682 regulatory protein UhpC; Provisional; Region: PRK11663 1048689012683 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689012684 putative substrate translocation pore; other site 1048689012685 sensory histidine kinase UhpB; Provisional; Region: PRK11644 1048689012686 MASE1; Region: MASE1; pfam05231 1048689012687 Histidine kinase; Region: HisKA_3; pfam07730 1048689012688 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 1048689012689 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1048689012690 active site 1048689012691 phosphorylation site [posttranslational modification] 1048689012692 intermolecular recognition site; other site 1048689012693 dimerization interface [polypeptide binding]; other site 1048689012694 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1048689012695 DNA binding residues [nucleotide binding] 1048689012696 dimerization interface [polypeptide binding]; other site 1048689012697 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 1048689012698 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1048689012699 putative valine binding site [chemical binding]; other site 1048689012700 dimer interface [polypeptide binding]; other site 1048689012701 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 1048689012702 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1048689012703 PYR/PP interface [polypeptide binding]; other site 1048689012704 dimer interface [polypeptide binding]; other site 1048689012705 TPP binding site [chemical binding]; other site 1048689012706 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1048689012707 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1048689012708 TPP-binding site [chemical binding]; other site 1048689012709 dimer interface [polypeptide binding]; other site 1048689012710 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 1048689012711 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689012712 putative substrate translocation pore; other site 1048689012713 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 1048689012714 Domain of unknown function (DUF202); Region: DUF202; pfam02656 1048689012715 Predicted membrane protein [Function unknown]; Region: COG2149 1048689012716 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1048689012717 Sulfatase; Region: Sulfatase; pfam00884 1048689012718 putative transporter; Provisional; Region: PRK10484 1048689012719 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 1048689012720 Na binding site [ion binding]; other site 1048689012721 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1048689012722 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1048689012723 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1048689012724 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1048689012725 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 1048689012726 NAD binding site [chemical binding]; other site 1048689012727 sugar binding site [chemical binding]; other site 1048689012728 divalent metal binding site [ion binding]; other site 1048689012729 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1048689012730 dimer interface [polypeptide binding]; other site 1048689012731 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 1048689012732 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 1048689012733 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1048689012734 active site turn [active] 1048689012735 phosphorylation site [posttranslational modification] 1048689012736 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1048689012737 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1048689012738 DNA-binding site [nucleotide binding]; DNA binding site 1048689012739 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1048689012740 putative transporter; Validated; Region: PRK03818 1048689012741 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1048689012742 TrkA-C domain; Region: TrkA_C; pfam02080 1048689012743 TrkA-C domain; Region: TrkA_C; pfam02080 1048689012744 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 1048689012745 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1048689012746 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1048689012747 putative dimer interface [polypeptide binding]; other site 1048689012748 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1048689012749 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1048689012750 putative dimer interface [polypeptide binding]; other site 1048689012751 hypothetical protein; Provisional; Region: PRK11616 1048689012752 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 1048689012753 putative oxidoreductase; Provisional; Region: PRK11445 1048689012754 hypothetical protein; Provisional; Region: PRK07236 1048689012755 hypothetical protein; Provisional; Region: PRK10215 1048689012756 sugar phosphate phosphatase; Provisional; Region: PRK10513 1048689012757 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1048689012758 active site 1048689012759 motif I; other site 1048689012760 motif II; other site 1048689012761 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1048689012762 hypothetical protein; Provisional; Region: PRK11426 1048689012763 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 1048689012764 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1048689012765 Mg2+ binding site [ion binding]; other site 1048689012766 G-X-G motif; other site 1048689012767 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1048689012768 anchoring element; other site 1048689012769 dimer interface [polypeptide binding]; other site 1048689012770 ATP binding site [chemical binding]; other site 1048689012771 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1048689012772 active site 1048689012773 putative metal-binding site [ion binding]; other site 1048689012774 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1048689012775 recF protein; Region: recf; TIGR00611 1048689012776 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1048689012777 Walker A/P-loop; other site 1048689012778 ATP binding site [chemical binding]; other site 1048689012779 Q-loop/lid; other site 1048689012780 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1048689012781 ABC transporter signature motif; other site 1048689012782 Walker B; other site 1048689012783 D-loop; other site 1048689012784 H-loop/switch region; other site 1048689012785 DNA polymerase III subunit beta; Validated; Region: PRK05643 1048689012786 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1048689012787 putative DNA binding surface [nucleotide binding]; other site 1048689012788 dimer interface [polypeptide binding]; other site 1048689012789 beta-clamp/clamp loader binding surface; other site 1048689012790 beta-clamp/translesion DNA polymerase binding surface; other site 1048689012791 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1048689012792 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1048689012793 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1048689012794 Walker A motif; other site 1048689012795 ATP binding site [chemical binding]; other site 1048689012796 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1048689012797 Walker B motif; other site 1048689012798 arginine finger; other site 1048689012799 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1048689012800 DnaA box-binding interface [nucleotide binding]; other site 1048689012801 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 1048689012802 ribonuclease P; Reviewed; Region: rnpA; PRK01732 1048689012803 hypothetical protein; Validated; Region: PRK00041 1048689012804 membrane protein insertase; Provisional; Region: PRK01318 1048689012805 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1048689012806 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1048689012807 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1048689012808 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1048689012809 G1 box; other site 1048689012810 GTP/Mg2+ binding site [chemical binding]; other site 1048689012811 Switch I region; other site 1048689012812 G2 box; other site 1048689012813 Switch II region; other site 1048689012814 G3 box; other site 1048689012815 G4 box; other site 1048689012816 G5 box; other site 1048689012817 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1048689012818 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 1048689012819 tryptophanase, leader peptide-associated; Region: tnaA_trp_ase; TIGR02617 1048689012820 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1048689012821 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1048689012822 catalytic residue [active] 1048689012823 tryptophan permease TnaB; Provisional; Region: PRK09664 1048689012824 aromatic amino acid transport protein; Region: araaP; TIGR00837 1048689012825 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 1048689012826 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689012827 putative substrate translocation pore; other site 1048689012828 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 1048689012829 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1048689012830 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1048689012831 substrate binding pocket [chemical binding]; other site 1048689012832 dimerization interface [polypeptide binding]; other site 1048689012833 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1048689012834 Predicted flavoprotein [General function prediction only]; Region: COG0431 1048689012835 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1048689012836 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1048689012837 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 1048689012838 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1048689012839 active site 1048689012840 motif I; other site 1048689012841 motif II; other site 1048689012842 transcriptional regulator PhoU; Provisional; Region: PRK11115 1048689012843 PhoU domain; Region: PhoU; pfam01895 1048689012844 PhoU domain; Region: PhoU; pfam01895 1048689012845 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 1048689012846 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1048689012847 Walker A/P-loop; other site 1048689012848 ATP binding site [chemical binding]; other site 1048689012849 Q-loop/lid; other site 1048689012850 ABC transporter signature motif; other site 1048689012851 Walker B; other site 1048689012852 D-loop; other site 1048689012853 H-loop/switch region; other site 1048689012854 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 1048689012855 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048689012856 dimer interface [polypeptide binding]; other site 1048689012857 conserved gate region; other site 1048689012858 putative PBP binding loops; other site 1048689012859 ABC-ATPase subunit interface; other site 1048689012860 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 1048689012861 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048689012862 dimer interface [polypeptide binding]; other site 1048689012863 conserved gate region; other site 1048689012864 putative PBP binding loops; other site 1048689012865 ABC-ATPase subunit interface; other site 1048689012866 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1048689012867 Fimbrial protein; Region: Fimbrial; cl01416 1048689012868 Fimbrial protein; Region: Fimbrial; cl01416 1048689012869 potential frameshift: common BLAST hit: gi|254795730|ref|YP_003080567.1| fimbrial usher 1048689012870 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1048689012871 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1048689012872 fimbrial protein; Provisional; Region: lpfA; PRK15289 1048689012873 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1048689012874 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1048689012875 glutaminase active site [active] 1048689012876 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1048689012877 dimer interface [polypeptide binding]; other site 1048689012878 active site 1048689012879 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1048689012880 dimer interface [polypeptide binding]; other site 1048689012881 active site 1048689012882 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 1048689012883 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1048689012884 Substrate binding site; other site 1048689012885 Mg++ binding site; other site 1048689012886 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1048689012887 active site 1048689012888 substrate binding site [chemical binding]; other site 1048689012889 CoA binding site [chemical binding]; other site 1048689012890 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1048689012891 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1048689012892 gamma subunit interface [polypeptide binding]; other site 1048689012893 epsilon subunit interface [polypeptide binding]; other site 1048689012894 LBP interface [polypeptide binding]; other site 1048689012895 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1048689012896 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1048689012897 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1048689012898 alpha subunit interaction interface [polypeptide binding]; other site 1048689012899 Walker A motif; other site 1048689012900 ATP binding site [chemical binding]; other site 1048689012901 Walker B motif; other site 1048689012902 inhibitor binding site; inhibition site 1048689012903 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1048689012904 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1048689012905 core domain interface [polypeptide binding]; other site 1048689012906 delta subunit interface [polypeptide binding]; other site 1048689012907 epsilon subunit interface [polypeptide binding]; other site 1048689012908 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1048689012909 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1048689012910 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1048689012911 beta subunit interaction interface [polypeptide binding]; other site 1048689012912 Walker A motif; other site 1048689012913 ATP binding site [chemical binding]; other site 1048689012914 Walker B motif; other site 1048689012915 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1048689012916 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1048689012917 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1048689012918 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1048689012919 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1048689012920 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1048689012921 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1048689012922 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1048689012923 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 1048689012924 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1048689012925 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1048689012926 S-adenosylmethionine binding site [chemical binding]; other site 1048689012927 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1048689012928 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1048689012929 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1048689012930 FMN-binding protein MioC; Provisional; Region: PRK09004 1048689012931 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 1048689012932 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1048689012933 putative DNA binding site [nucleotide binding]; other site 1048689012934 putative Zn2+ binding site [ion binding]; other site 1048689012935 AsnC family; Region: AsnC_trans_reg; pfam01037 1048689012936 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 1048689012937 dimer interface [polypeptide binding]; other site 1048689012938 active site 1048689012939 hypothetical protein; Provisional; Region: yieM; PRK10997 1048689012940 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 1048689012941 metal ion-dependent adhesion site (MIDAS); other site 1048689012942 regulatory ATPase RavA; Provisional; Region: PRK13531 1048689012943 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1048689012944 Walker A motif; other site 1048689012945 ATP binding site [chemical binding]; other site 1048689012946 Walker B motif; other site 1048689012947 arginine finger; other site 1048689012948 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 1048689012949 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 1048689012950 potassium uptake protein; Region: kup; TIGR00794 1048689012951 D-ribose pyranase; Provisional; Region: PRK11797 1048689012952 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 1048689012953 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1048689012954 Walker A/P-loop; other site 1048689012955 ATP binding site [chemical binding]; other site 1048689012956 Q-loop/lid; other site 1048689012957 ABC transporter signature motif; other site 1048689012958 Walker B; other site 1048689012959 D-loop; other site 1048689012960 H-loop/switch region; other site 1048689012961 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1048689012962 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1048689012963 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1048689012964 TM-ABC transporter signature motif; other site 1048689012965 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 1048689012966 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1048689012967 ligand binding site [chemical binding]; other site 1048689012968 dimerization interface [polypeptide binding]; other site 1048689012969 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1048689012970 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1048689012971 substrate binding site [chemical binding]; other site 1048689012972 dimer interface [polypeptide binding]; other site 1048689012973 ATP binding site [chemical binding]; other site 1048689012974 transcriptional repressor RbsR; Provisional; Region: PRK10423 1048689012975 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1048689012976 DNA binding site [nucleotide binding] 1048689012977 domain linker motif; other site 1048689012978 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 1048689012979 dimerization interface [polypeptide binding]; other site 1048689012980 ligand binding site [chemical binding]; other site 1048689012981 putative transporter; Provisional; Region: PRK10504 1048689012982 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689012983 putative substrate translocation pore; other site 1048689012984 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689012985 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1048689012986 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1048689012987 DNA-binding site [nucleotide binding]; DNA binding site 1048689012988 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1048689012989 transcriptional regulator HdfR; Provisional; Region: PRK03601 1048689012990 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1048689012991 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1048689012992 dimerization interface [polypeptide binding]; other site 1048689012993 hypothetical protein; Provisional; Region: PRK11027 1048689012994 putative ATP-dependent protease; Provisional; Region: PRK09862 1048689012995 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1048689012996 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1048689012997 Walker A motif; other site 1048689012998 ATP binding site [chemical binding]; other site 1048689012999 Walker B motif; other site 1048689013000 arginine finger; other site 1048689013001 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1048689013002 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 1048689013003 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1048689013004 PYR/PP interface [polypeptide binding]; other site 1048689013005 dimer interface [polypeptide binding]; other site 1048689013006 TPP binding site [chemical binding]; other site 1048689013007 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1048689013008 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1048689013009 TPP-binding site [chemical binding]; other site 1048689013010 dimer interface [polypeptide binding]; other site 1048689013011 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 1048689013012 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1048689013013 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1048689013014 homodimer interface [polypeptide binding]; other site 1048689013015 substrate-cofactor binding pocket; other site 1048689013016 catalytic residue [active] 1048689013017 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1048689013018 threonine dehydratase; Reviewed; Region: PRK09224 1048689013019 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1048689013020 tetramer interface [polypeptide binding]; other site 1048689013021 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048689013022 catalytic residue [active] 1048689013023 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 1048689013024 putative Ile/Val binding site [chemical binding]; other site 1048689013025 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1048689013026 putative Ile/Val binding site [chemical binding]; other site 1048689013027 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1048689013028 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 1048689013029 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 1048689013030 putative dimerization interface [polypeptide binding]; other site 1048689013031 ketol-acid reductoisomerase; Validated; Region: PRK05225 1048689013032 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1048689013033 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1048689013034 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1048689013035 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 1048689013036 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 1048689013037 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3692 1048689013038 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 1048689013039 Part of AAA domain; Region: AAA_19; pfam13245 1048689013040 Family description; Region: UvrD_C_2; pfam13538 1048689013041 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 1048689013042 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1048689013043 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 1048689013044 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1048689013045 ATP binding site [chemical binding]; other site 1048689013046 Mg++ binding site [ion binding]; other site 1048689013047 motif III; other site 1048689013048 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1048689013049 nucleotide binding region [chemical binding]; other site 1048689013050 ATP-binding site [chemical binding]; other site 1048689013051 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1048689013052 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1048689013053 catalytic residues [active] 1048689013054 putative rho operon leader peptide; Provisional; Region: PRK09979 1048689013055 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1048689013056 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1048689013057 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1048689013058 RNA binding site [nucleotide binding]; other site 1048689013059 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1048689013060 multimer interface [polypeptide binding]; other site 1048689013061 Walker A motif; other site 1048689013062 ATP binding site [chemical binding]; other site 1048689013063 Walker B motif; other site 1048689013064 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 1048689013065 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1048689013066 Mg++ binding site [ion binding]; other site 1048689013067 putative catalytic motif [active] 1048689013068 substrate binding site [chemical binding]; other site 1048689013069 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 1048689013070 Chain length determinant protein; Region: Wzz; pfam02706 1048689013071 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 1048689013072 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1048689013073 active site 1048689013074 homodimer interface [polypeptide binding]; other site 1048689013075 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 1048689013076 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1048689013077 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1048689013078 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1048689013079 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 1048689013080 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1048689013081 NAD binding site [chemical binding]; other site 1048689013082 substrate binding site [chemical binding]; other site 1048689013083 homodimer interface [polypeptide binding]; other site 1048689013084 active site 1048689013085 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1048689013086 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1048689013087 substrate binding site; other site 1048689013088 tetramer interface; other site 1048689013089 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 1048689013090 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1048689013091 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1048689013092 inhibitor-cofactor binding pocket; inhibition site 1048689013093 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048689013094 catalytic residue [active] 1048689013095 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1048689013096 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 1048689013097 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 1048689013098 putative common antigen polymerase; Provisional; Region: PRK02975 1048689013099 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1048689013100 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1048689013101 putative transport protein YifK; Provisional; Region: PRK10746 1048689013102 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 1048689013103 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1048689013104 FeS/SAM binding site; other site 1048689013105 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1048689013106 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1048689013107 Sulfatase; Region: Sulfatase; pfam00884 1048689013108 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 1048689013109 HemY protein N-terminus; Region: HemY_N; pfam07219 1048689013110 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 1048689013111 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 1048689013112 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 1048689013113 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1048689013114 active site 1048689013115 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1048689013116 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1048689013117 domain interfaces; other site 1048689013118 active site 1048689013119 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 1048689013120 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 1048689013121 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 1048689013122 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 1048689013123 putative iron binding site [ion binding]; other site 1048689013124 hypothetical protein; Provisional; Region: PRK09807 1048689013125 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 1048689013126 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1048689013127 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1048689013128 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1048689013129 hypothetical protein; Provisional; Region: PRK10963 1048689013130 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 1048689013131 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1048689013132 active site 1048689013133 DNA binding site [nucleotide binding] 1048689013134 Int/Topo IB signature motif; other site 1048689013135 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 1048689013136 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1048689013137 motif II; other site 1048689013138 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 1048689013139 Part of AAA domain; Region: AAA_19; pfam13245 1048689013140 Family description; Region: UvrD_C_2; pfam13538 1048689013141 Uncharacterized conserved protein [Function unknown]; Region: COG1912 1048689013142 Predicted periplasmic protein [Function unknown]; Region: COG3698 1048689013143 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1048689013144 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1048689013145 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 1048689013146 Cl binding site [ion binding]; other site 1048689013147 oligomer interface [polypeptide binding]; other site 1048689013148 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 1048689013149 Protein of unknown function (DUF3289); Region: DUF3289; cl11840 1048689013150 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085 1048689013151 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1048689013152 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 1048689013153 EamA-like transporter family; Region: EamA; cl17759 1048689013154 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1048689013155 CoenzymeA binding site [chemical binding]; other site 1048689013156 subunit interaction site [polypeptide binding]; other site 1048689013157 PHB binding site; other site 1048689013158 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 1048689013159 dimerization interface [polypeptide binding]; other site 1048689013160 substrate binding site [chemical binding]; other site 1048689013161 active site 1048689013162 calcium binding site [ion binding]; other site 1048689013163 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 1048689013164 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1048689013165 ATP binding site [chemical binding]; other site 1048689013166 putative Mg++ binding site [ion binding]; other site 1048689013167 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1048689013168 nucleotide binding region [chemical binding]; other site 1048689013169 ATP-binding site [chemical binding]; other site 1048689013170 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1048689013171 Helicase and RNase D C-terminal; Region: HRDC; smart00341 1048689013172 threonine efflux system; Provisional; Region: PRK10229 1048689013173 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 1048689013174 lysophospholipase L2; Provisional; Region: PRK10749 1048689013175 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1048689013176 putative hydrolase; Provisional; Region: PRK10976 1048689013177 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1048689013178 active site 1048689013179 motif I; other site 1048689013180 motif II; other site 1048689013181 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1048689013182 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1048689013183 EamA-like transporter family; Region: EamA; pfam00892 1048689013184 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 1048689013185 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1048689013186 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 1048689013187 putative dimerization interface [polypeptide binding]; other site 1048689013188 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1048689013189 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1048689013190 THF binding site; other site 1048689013191 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1048689013192 substrate binding site [chemical binding]; other site 1048689013193 THF binding site; other site 1048689013194 zinc-binding site [ion binding]; other site 1048689013195 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1048689013196 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1048689013197 uridine phosphorylase; Provisional; Region: PRK11178 1048689013198 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 1048689013199 DNA recombination protein RmuC; Provisional; Region: PRK10361 1048689013200 RmuC family; Region: RmuC; pfam02646 1048689013201 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1048689013202 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1048689013203 S-adenosylmethionine binding site [chemical binding]; other site 1048689013204 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 1048689013205 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1048689013206 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 1048689013207 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1048689013208 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 1048689013209 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 1048689013210 sec-independent translocase; Provisional; Region: PRK01770 1048689013211 sec-independent translocase; Provisional; Region: tatB; PRK00404 1048689013212 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 1048689013213 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1048689013214 active site 1048689013215 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 1048689013216 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 1048689013217 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 1048689013218 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 1048689013219 FMN reductase; Validated; Region: fre; PRK08051 1048689013220 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 1048689013221 FAD binding pocket [chemical binding]; other site 1048689013222 FAD binding motif [chemical binding]; other site 1048689013223 phosphate binding motif [ion binding]; other site 1048689013224 beta-alpha-beta structure motif; other site 1048689013225 NAD binding pocket [chemical binding]; other site 1048689013226 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 1048689013227 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1048689013228 dimer interface [polypeptide binding]; other site 1048689013229 active site 1048689013230 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 1048689013231 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1048689013232 substrate binding site [chemical binding]; other site 1048689013233 oxyanion hole (OAH) forming residues; other site 1048689013234 trimer interface [polypeptide binding]; other site 1048689013235 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1048689013236 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1048689013237 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1048689013238 proline dipeptidase; Provisional; Region: PRK13607 1048689013239 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1048689013240 active site 1048689013241 hypothetical protein; Provisional; Region: PRK11568 1048689013242 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1048689013243 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1048689013244 potassium transporter; Provisional; Region: PRK10750 1048689013245 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1048689013246 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 1048689013247 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 1048689013248 Walker A motif; other site 1048689013249 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1048689013250 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1048689013251 GTP binding site; other site 1048689013252 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 1048689013253 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1048689013254 serine/threonine protein kinase; Provisional; Region: PRK11768 1048689013255 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 1048689013256 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1048689013257 catalytic residues [active] 1048689013258 hinge region; other site 1048689013259 alpha helical domain; other site 1048689013260 hypothetical protein; Provisional; Region: PRK11367 1048689013261 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 1048689013262 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1048689013263 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 1048689013264 putative acyl-acceptor binding pocket; other site 1048689013265 DNA polymerase I; Provisional; Region: PRK05755 1048689013266 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1048689013267 active site 1048689013268 metal binding site 1 [ion binding]; metal-binding site 1048689013269 putative 5' ssDNA interaction site; other site 1048689013270 metal binding site 3; metal-binding site 1048689013271 metal binding site 2 [ion binding]; metal-binding site 1048689013272 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1048689013273 putative DNA binding site [nucleotide binding]; other site 1048689013274 putative metal binding site [ion binding]; other site 1048689013275 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 1048689013276 active site 1048689013277 catalytic site [active] 1048689013278 substrate binding site [chemical binding]; other site 1048689013279 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1048689013280 active site 1048689013281 DNA binding site [nucleotide binding] 1048689013282 catalytic site [active] 1048689013283 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1048689013284 G1 box; other site 1048689013285 GTP/Mg2+ binding site [chemical binding]; other site 1048689013286 Switch I region; other site 1048689013287 G2 box; other site 1048689013288 G3 box; other site 1048689013289 Switch II region; other site 1048689013290 G4 box; other site 1048689013291 G5 box; other site 1048689013292 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078 1048689013293 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 1048689013294 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1048689013295 FeS/SAM binding site; other site 1048689013296 HemN C-terminal domain; Region: HemN_C; pfam06969 1048689013297 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 1048689013298 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1048689013299 active site 1048689013300 phosphorylation site [posttranslational modification] 1048689013301 intermolecular recognition site; other site 1048689013302 dimerization interface [polypeptide binding]; other site 1048689013303 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1048689013304 Walker A motif; other site 1048689013305 ATP binding site [chemical binding]; other site 1048689013306 Walker B motif; other site 1048689013307 arginine finger; other site 1048689013308 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1048689013309 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 1048689013310 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1048689013311 putative active site [active] 1048689013312 heme pocket [chemical binding]; other site 1048689013313 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1048689013314 dimer interface [polypeptide binding]; other site 1048689013315 phosphorylation site [posttranslational modification] 1048689013316 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1048689013317 ATP binding site [chemical binding]; other site 1048689013318 Mg2+ binding site [ion binding]; other site 1048689013319 G-X-G motif; other site 1048689013320 glutamine synthetase; Provisional; Region: glnA; PRK09469 1048689013321 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1048689013322 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1048689013323 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1048689013324 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1048689013325 G1 box; other site 1048689013326 putative GEF interaction site [polypeptide binding]; other site 1048689013327 GTP/Mg2+ binding site [chemical binding]; other site 1048689013328 Switch I region; other site 1048689013329 G2 box; other site 1048689013330 G3 box; other site 1048689013331 Switch II region; other site 1048689013332 G4 box; other site 1048689013333 G5 box; other site 1048689013334 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1048689013335 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1048689013336 transcriptional regulator protein; Region: phnR; TIGR03337 1048689013337 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1048689013338 DNA-binding site [nucleotide binding]; DNA binding site 1048689013339 UTRA domain; Region: UTRA; pfam07702 1048689013340 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1048689013341 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689013342 putative substrate translocation pore; other site 1048689013343 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1048689013344 outer membrane porin L; Provisional; Region: ompL; PRK09980 1048689013345 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1048689013346 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689013347 putative substrate translocation pore; other site 1048689013348 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1048689013349 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1048689013350 alpha-glucosidase; Provisional; Region: PRK10426 1048689013351 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1048689013352 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 1048689013353 putative active site [active] 1048689013354 putative catalytic site [active] 1048689013355 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1048689013356 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 1048689013357 active site 1048689013358 catalytic residues [active] 1048689013359 potential frameshift: common BLAST hit: gi|291285291|ref|YP_003502109.1| N-acylglucosamine 2-epimerase 1048689013360 Tagatose-1,6-bisphosphate aldolase [Carbohydrate transport and metabolism]; Region: LacD; COG3684 1048689013361 catalytic residue [active] 1048689013362 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 1048689013363 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1048689013364 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1048689013365 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 1048689013366 substrate binding site [chemical binding]; other site 1048689013367 ATP binding site [chemical binding]; other site 1048689013368 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1048689013369 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1048689013370 putative DNA binding site [nucleotide binding]; other site 1048689013371 putative Zn2+ binding site [ion binding]; other site 1048689013372 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1048689013373 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1048689013374 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1048689013375 motif II; other site 1048689013376 hypothetical protein; Reviewed; Region: PRK01637 1048689013377 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1048689013378 putative active site [active] 1048689013379 dimerization interface [polypeptide binding]; other site 1048689013380 putative tRNAtyr binding site [nucleotide binding]; other site 1048689013381 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1048689013382 Coenzyme A binding pocket [chemical binding]; other site 1048689013383 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 1048689013384 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1048689013385 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 1048689013386 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 1048689013387 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 1048689013388 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 1048689013389 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 1048689013390 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 1048689013391 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1048689013392 molybdopterin cofactor binding site; other site 1048689013393 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 1048689013394 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1048689013395 molybdopterin cofactor binding site; other site 1048689013396 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1048689013397 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1048689013398 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 1048689013399 putative frv operon regulatory protein; Provisional; Region: PRK09863 1048689013400 HTH domain; Region: HTH_11; pfam08279 1048689013401 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1048689013402 active site 1048689013403 phosphorylation site [posttranslational modification] 1048689013404 putative peptidase; Provisional; Region: PRK09864 1048689013405 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1048689013406 oligomer interface [polypeptide binding]; other site 1048689013407 active site 1048689013408 metal binding site [ion binding]; metal-binding site 1048689013409 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 1048689013410 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1048689013411 active site 1048689013412 P-loop; other site 1048689013413 phosphorylation site [posttranslational modification] 1048689013414 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1048689013415 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1048689013416 active site 1048689013417 phosphorylation site [posttranslational modification] 1048689013418 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 1048689013419 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1048689013420 intersubunit interface [polypeptide binding]; other site 1048689013421 active site 1048689013422 Zn2+ binding site [ion binding]; other site 1048689013423 L-rhamnose isomerase; Provisional; Region: PRK01076 1048689013424 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 1048689013425 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 1048689013426 N- and C-terminal domain interface [polypeptide binding]; other site 1048689013427 active site 1048689013428 putative catalytic site [active] 1048689013429 metal binding site [ion binding]; metal-binding site 1048689013430 ATP binding site [chemical binding]; other site 1048689013431 rhamnulokinase; Provisional; Region: rhaB; PRK10640 1048689013432 carbohydrate binding site [chemical binding]; other site 1048689013433 transcriptional activator RhaS; Provisional; Region: PRK13503 1048689013434 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1048689013435 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1048689013436 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1048689013437 transcriptional activator RhaR; Provisional; Region: PRK13500 1048689013438 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1048689013439 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1048689013440 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1048689013441 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 1048689013442 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 1048689013443 superoxide dismutase; Provisional; Region: PRK10925 1048689013444 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1048689013445 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1048689013446 2-keto-3-deoxygluconate transporter; Region: kdgT; TIGR00793 1048689013447 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 1048689013448 MOSC domain; Region: MOSC; pfam03473 1048689013449 3-alpha domain; Region: 3-alpha; pfam03475 1048689013450 two-component sensor protein; Provisional; Region: cpxA; PRK09470 1048689013451 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1048689013452 dimerization interface [polypeptide binding]; other site 1048689013453 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1048689013454 dimer interface [polypeptide binding]; other site 1048689013455 phosphorylation site [posttranslational modification] 1048689013456 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1048689013457 ATP binding site [chemical binding]; other site 1048689013458 Mg2+ binding site [ion binding]; other site 1048689013459 G-X-G motif; other site 1048689013460 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 1048689013461 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1048689013462 active site 1048689013463 intermolecular recognition site; other site 1048689013464 dimerization interface [polypeptide binding]; other site 1048689013465 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1048689013466 DNA binding site [nucleotide binding] 1048689013467 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1048689013468 dimer interface [polypeptide binding]; other site 1048689013469 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 1048689013470 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1048689013471 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 1048689013472 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1048689013473 active site 1048689013474 ADP/pyrophosphate binding site [chemical binding]; other site 1048689013475 dimerization interface [polypeptide binding]; other site 1048689013476 allosteric effector site; other site 1048689013477 fructose-1,6-bisphosphate binding site; other site 1048689013478 sulfate transporter subunit; Provisional; Region: PRK10752 1048689013479 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1048689013480 CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672 1048689013481 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1048689013482 triosephosphate isomerase; Provisional; Region: PRK14567 1048689013483 substrate binding site [chemical binding]; other site 1048689013484 dimer interface [polypeptide binding]; other site 1048689013485 catalytic triad [active] 1048689013486 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 1048689013487 Predicted membrane protein [Function unknown]; Region: COG3152 1048689013488 hypothetical protein; Provisional; Region: PRK09981 1048689013489 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1048689013490 Ligand Binding Site [chemical binding]; other site 1048689013491 ferredoxin-NADP reductase; Provisional; Region: PRK10926 1048689013492 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1048689013493 FAD binding pocket [chemical binding]; other site 1048689013494 FAD binding motif [chemical binding]; other site 1048689013495 phosphate binding motif [ion binding]; other site 1048689013496 beta-alpha-beta structure motif; other site 1048689013497 NAD binding pocket [chemical binding]; other site 1048689013498 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1048689013499 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1048689013500 putative active site [active] 1048689013501 glycerol kinase; Provisional; Region: glpK; PRK00047 1048689013502 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1048689013503 N- and C-terminal domain interface [polypeptide binding]; other site 1048689013504 active site 1048689013505 MgATP binding site [chemical binding]; other site 1048689013506 catalytic site [active] 1048689013507 metal binding site [ion binding]; metal-binding site 1048689013508 glycerol binding site [chemical binding]; other site 1048689013509 homotetramer interface [polypeptide binding]; other site 1048689013510 homodimer interface [polypeptide binding]; other site 1048689013511 FBP binding site [chemical binding]; other site 1048689013512 protein IIAGlc interface [polypeptide binding]; other site 1048689013513 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1048689013514 amphipathic channel; other site 1048689013515 Asn-Pro-Ala signature motifs; other site 1048689013516 septal ring assembly protein ZapB; Provisional; Region: PRK15422 1048689013517 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1048689013518 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 1048689013519 UbiA prenyltransferase family; Region: UbiA; pfam01040 1048689013520 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1048689013521 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1048689013522 Walker A motif; other site 1048689013523 ATP binding site [chemical binding]; other site 1048689013524 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1048689013525 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1048689013526 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1048689013527 active site 1048689013528 HslU subunit interaction site [polypeptide binding]; other site 1048689013529 essential cell division protein FtsN; Provisional; Region: PRK10927 1048689013530 cell division protein FtsN; Provisional; Region: PRK12757 1048689013531 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1048689013532 DNA binding site [nucleotide binding] 1048689013533 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 1048689013534 domain linker motif; other site 1048689013535 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 1048689013536 dimerization interface [polypeptide binding]; other site 1048689013537 ligand binding site [chemical binding]; other site 1048689013538 primosome assembly protein PriA; Validated; Region: PRK05580 1048689013539 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1048689013540 ATP binding site [chemical binding]; other site 1048689013541 putative Mg++ binding site [ion binding]; other site 1048689013542 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1048689013543 ATP-binding site [chemical binding]; other site 1048689013544 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1048689013545 PAAR motif; Region: PAAR_motif; cl15808 1048689013546 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1048689013547 RHS Repeat; Region: RHS_repeat; pfam05593 1048689013548 RHS Repeat; Region: RHS_repeat; pfam05593 1048689013549 RHS Repeat; Region: RHS_repeat; pfam05593 1048689013550 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1048689013551 RHS Repeat; Region: RHS_repeat; pfam05593 1048689013552 RHS Repeat; Region: RHS_repeat; pfam05593 1048689013553 RHS protein; Region: RHS; pfam03527 1048689013554 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1048689013555 Domain of unknown function (DUF4329); Region: DUF4329; pfam14220 1048689013556 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 1048689013557 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 1048689013558 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 1048689013559 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 1048689013560 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 1048689013561 hypothetical protein; Provisional; Region: PRK10030 1048689013562 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 1048689013563 dimerization interface [polypeptide binding]; other site 1048689013564 DNA binding site [nucleotide binding] 1048689013565 corepressor binding sites; other site 1048689013566 cystathionine gamma-synthase; Provisional; Region: PRK08045 1048689013567 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1048689013568 homodimer interface [polypeptide binding]; other site 1048689013569 substrate-cofactor binding pocket; other site 1048689013570 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048689013571 catalytic residue [active] 1048689013572 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 1048689013573 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 1048689013574 putative catalytic residues [active] 1048689013575 putative nucleotide binding site [chemical binding]; other site 1048689013576 putative aspartate binding site [chemical binding]; other site 1048689013577 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 1048689013578 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1048689013579 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1048689013580 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1048689013581 FAD binding site [chemical binding]; other site 1048689013582 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1048689013583 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 1048689013584 heme binding site [chemical binding]; other site 1048689013585 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1048689013586 EamA-like transporter family; Region: EamA; pfam00892 1048689013587 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1048689013588 EamA-like transporter family; Region: EamA; pfam00892 1048689013589 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738 1048689013590 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1048689013591 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 1048689013592 dimer interface [polypeptide binding]; other site 1048689013593 active site 1048689013594 metal binding site [ion binding]; metal-binding site 1048689013595 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1048689013596 active site 1048689013597 intersubunit interactions; other site 1048689013598 catalytic residue [active] 1048689013599 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1048689013600 dimerization domain swap beta strand [polypeptide binding]; other site 1048689013601 regulatory protein interface [polypeptide binding]; other site 1048689013602 active site 1048689013603 regulatory phosphorylation site [posttranslational modification]; other site 1048689013604 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1048689013605 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1048689013606 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1048689013607 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1048689013608 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1048689013609 active site 1048689013610 phosphorylation site [posttranslational modification] 1048689013611 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 1048689013612 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1048689013613 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1048689013614 active site 1048689013615 P-loop; other site 1048689013616 phosphorylation site [posttranslational modification] 1048689013617 putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983 1048689013618 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 1048689013619 dimer interface [polypeptide binding]; other site 1048689013620 active site 1048689013621 glycine loop; other site 1048689013622 pyruvate formate lyase II activase; Provisional; Region: PRK10076 1048689013623 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1048689013624 active site 1048689013625 P-loop; other site 1048689013626 phosphorylation site [posttranslational modification] 1048689013627 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1048689013628 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1048689013629 hypothetical protein; Provisional; Region: PRK10649 1048689013630 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1048689013631 Sulfatase; Region: Sulfatase; pfam00884 1048689013632 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 1048689013633 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1048689013634 acetylornithine deacetylase; Provisional; Region: PRK05111 1048689013635 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 1048689013636 metal binding site [ion binding]; metal-binding site 1048689013637 putative dimer interface [polypeptide binding]; other site 1048689013638 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1048689013639 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1048689013640 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 1048689013641 nucleotide binding site [chemical binding]; other site 1048689013642 N-acetyl-L-glutamate binding site [chemical binding]; other site 1048689013643 argininosuccinate lyase; Provisional; Region: PRK04833 1048689013644 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1048689013645 active sites [active] 1048689013646 tetramer interface [polypeptide binding]; other site 1048689013647 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1048689013648 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1048689013649 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1048689013650 dimerization interface [polypeptide binding]; other site 1048689013651 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1048689013652 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1048689013653 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1048689013654 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1048689013655 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 1048689013656 metal binding site [ion binding]; metal-binding site 1048689013657 putative dimer interface [polypeptide binding]; other site 1048689013658 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689013659 metabolite-proton symporter; Region: 2A0106; TIGR00883 1048689013660 putative substrate translocation pore; other site 1048689013661 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 1048689013662 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1048689013663 hypothetical protein; Provisional; Region: PRK11056 1048689013664 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 1048689013665 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1048689013666 S-adenosylmethionine binding site [chemical binding]; other site 1048689013667 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 1048689013668 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1048689013669 N-terminal plug; other site 1048689013670 ligand-binding site [chemical binding]; other site 1048689013671 glutamate racemase; Provisional; Region: PRK00865 1048689013672 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 1048689013673 FAD binding domain; Region: FAD_binding_4; pfam01565 1048689013674 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1048689013675 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1048689013676 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 1048689013677 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1048689013678 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1048689013679 pantothenate kinase; Provisional; Region: PRK05439 1048689013680 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1048689013681 ATP-binding site [chemical binding]; other site 1048689013682 CoA-binding site [chemical binding]; other site 1048689013683 Mg2+-binding site [ion binding]; other site 1048689013684 potential protein location (hypothetical protein ECO55CA74_22950 [Escherichia coli O55:H7 str. RM12579]) that overlaps RNA (tRNA-Y) 1048689013685 elongation factor Tu; Reviewed; Region: PRK00049 1048689013686 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1048689013687 G1 box; other site 1048689013688 GEF interaction site [polypeptide binding]; other site 1048689013689 GTP/Mg2+ binding site [chemical binding]; other site 1048689013690 Switch I region; other site 1048689013691 G2 box; other site 1048689013692 G3 box; other site 1048689013693 Switch II region; other site 1048689013694 G4 box; other site 1048689013695 G5 box; other site 1048689013696 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1048689013697 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1048689013698 Antibiotic Binding Site [chemical binding]; other site 1048689013699 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 1048689013700 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1048689013701 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1048689013702 putative homodimer interface [polypeptide binding]; other site 1048689013703 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1048689013704 heterodimer interface [polypeptide binding]; other site 1048689013705 homodimer interface [polypeptide binding]; other site 1048689013706 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1048689013707 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1048689013708 23S rRNA interface [nucleotide binding]; other site 1048689013709 L7/L12 interface [polypeptide binding]; other site 1048689013710 putative thiostrepton binding site; other site 1048689013711 L25 interface [polypeptide binding]; other site 1048689013712 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1048689013713 mRNA/rRNA interface [nucleotide binding]; other site 1048689013714 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1048689013715 23S rRNA interface [nucleotide binding]; other site 1048689013716 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1048689013717 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1048689013718 core dimer interface [polypeptide binding]; other site 1048689013719 peripheral dimer interface [polypeptide binding]; other site 1048689013720 L10 interface [polypeptide binding]; other site 1048689013721 L11 interface [polypeptide binding]; other site 1048689013722 putative EF-Tu interaction site [polypeptide binding]; other site 1048689013723 putative EF-G interaction site [polypeptide binding]; other site 1048689013724 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1048689013725 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1048689013726 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1048689013727 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1048689013728 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 1048689013729 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1048689013730 RPB3 interaction site [polypeptide binding]; other site 1048689013731 RPB1 interaction site [polypeptide binding]; other site 1048689013732 RPB11 interaction site [polypeptide binding]; other site 1048689013733 RPB10 interaction site [polypeptide binding]; other site 1048689013734 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1048689013735 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1048689013736 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1048689013737 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1048689013738 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1048689013739 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1048689013740 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1048689013741 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1048689013742 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1048689013743 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1048689013744 DNA binding site [nucleotide binding] 1048689013745 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1048689013746 stationary phase growth adaptation protein; Provisional; Region: PRK09717 1048689013747 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 1048689013748 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1048689013749 FeS/SAM binding site; other site 1048689013750 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1048689013751 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1048689013752 ThiS interaction site; other site 1048689013753 putative active site [active] 1048689013754 tetramer interface [polypeptide binding]; other site 1048689013755 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1048689013756 thiS-thiF/thiG interaction site; other site 1048689013757 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1048689013758 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 1048689013759 ATP binding site [chemical binding]; other site 1048689013760 substrate interface [chemical binding]; other site 1048689013761 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1048689013762 thiamine phosphate binding site [chemical binding]; other site 1048689013763 active site 1048689013764 pyrophosphate binding site [ion binding]; other site 1048689013765 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1048689013766 ThiC-associated domain; Region: ThiC-associated; pfam13667 1048689013767 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1048689013768 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 1048689013769 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 1048689013770 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1048689013771 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1048689013772 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1048689013773 putative NADH binding site [chemical binding]; other site 1048689013774 putative active site [active] 1048689013775 nudix motif; other site 1048689013776 putative metal binding site [ion binding]; other site 1048689013777 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1048689013778 substrate binding site [chemical binding]; other site 1048689013779 active site 1048689013780 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 1048689013781 Active_site [active] 1048689013782 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 1048689013783 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1048689013784 IHF dimer interface [polypeptide binding]; other site 1048689013785 IHF - DNA interface [nucleotide binding]; other site 1048689013786 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 1048689013787 zinc resistance protein; Provisional; Region: zraP; PRK11546 1048689013788 dimer interface [polypeptide binding]; other site 1048689013789 sensor protein ZraS; Provisional; Region: PRK10364 1048689013790 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1048689013791 dimer interface [polypeptide binding]; other site 1048689013792 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1048689013793 ATP binding site [chemical binding]; other site 1048689013794 Mg2+ binding site [ion binding]; other site 1048689013795 G-X-G motif; other site 1048689013796 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 1048689013797 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1048689013798 active site 1048689013799 phosphorylation site [posttranslational modification] 1048689013800 intermolecular recognition site; other site 1048689013801 dimerization interface [polypeptide binding]; other site 1048689013802 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1048689013803 Walker A motif; other site 1048689013804 ATP binding site [chemical binding]; other site 1048689013805 Walker B motif; other site 1048689013806 arginine finger; other site 1048689013807 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1048689013808 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1048689013809 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1048689013810 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1048689013811 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1048689013812 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1048689013813 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1048689013814 purine monophosphate binding site [chemical binding]; other site 1048689013815 dimer interface [polypeptide binding]; other site 1048689013816 putative catalytic residues [active] 1048689013817 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1048689013818 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1048689013819 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1048689013820 Coenzyme A binding pocket [chemical binding]; other site 1048689013821 homoserine O-succinyltransferase; Provisional; Region: PRK05368 1048689013822 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1048689013823 proposed active site lysine [active] 1048689013824 conserved cys residue [active] 1048689013825 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 1048689013826 malate synthase A; Region: malate_syn_A; TIGR01344 1048689013827 active site 1048689013828 isocitrate lyase; Provisional; Region: PRK15063 1048689013829 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1048689013830 tetramer interface [polypeptide binding]; other site 1048689013831 active site 1048689013832 Mg2+/Mn2+ binding site [ion binding]; other site 1048689013833 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 1048689013834 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 1048689013835 potential frameshift: common BLAST hit: gi|254796010|ref|YP_003080847.1| non-LEE-encoded type III secreted effector 1048689013836 transcriptional repressor IclR; Provisional; Region: PRK11569 1048689013837 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1048689013838 Bacterial transcriptional regulator; Region: IclR; pfam01614 1048689013839 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 1048689013840 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1048689013841 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1048689013842 substrate binding pocket [chemical binding]; other site 1048689013843 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1048689013844 B12 binding site [chemical binding]; other site 1048689013845 cobalt ligand [ion binding]; other site 1048689013846 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1048689013847 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1048689013848 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1048689013849 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1048689013850 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 1048689013851 active site pocket [active] 1048689013852 oxyanion hole [active] 1048689013853 catalytic triad [active] 1048689013854 active site nucleophile [active] 1048689013855 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 1048689013856 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 1048689013857 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1048689013858 putative NAD(P) binding site [chemical binding]; other site 1048689013859 catalytic Zn binding site [ion binding]; other site 1048689013860 PTS system, mannose/fructose/sorbose family, IID component; Region: EIID-AGA; TIGR00828 1048689013861 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 1048689013862 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1048689013863 active site 1048689013864 phosphorylation site [posttranslational modification] 1048689013865 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1048689013866 active pocket/dimerization site; other site 1048689013867 active site 1048689013868 phosphorylation site [posttranslational modification] 1048689013869 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 1048689013870 classical (c) SDRs; Region: SDR_c; cd05233 1048689013871 NAD(P) binding site [chemical binding]; other site 1048689013872 active site 1048689013873 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1048689013874 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1048689013875 putative DNA binding site [nucleotide binding]; other site 1048689013876 putative Zn2+ binding site [ion binding]; other site 1048689013877 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1048689013878 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 1048689013879 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1048689013880 RNA binding surface [nucleotide binding]; other site 1048689013881 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 1048689013882 probable active site [active] 1048689013883 hypothetical protein; Provisional; Region: PRK10515 1048689013884 aspartate kinase III; Validated; Region: PRK09084 1048689013885 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1048689013886 nucleotide binding site [chemical binding]; other site 1048689013887 substrate binding site [chemical binding]; other site 1048689013888 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 1048689013889 lysine allosteric regulatory site; other site 1048689013890 dimer interface [polypeptide binding]; other site 1048689013891 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 1048689013892 dimer interface [polypeptide binding]; other site 1048689013893 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1048689013894 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1048689013895 active site 1048689013896 dimer interface [polypeptide binding]; other site 1048689013897 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1048689013898 dimer interface [polypeptide binding]; other site 1048689013899 active site 1048689013900 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 1048689013901 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 1048689013902 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 1048689013903 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 1048689013904 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 1048689013905 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 1048689013906 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689013907 putative substrate translocation pore; other site 1048689013908 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689013909 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1048689013910 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048689013911 dimer interface [polypeptide binding]; other site 1048689013912 conserved gate region; other site 1048689013913 putative PBP binding loops; other site 1048689013914 ABC-ATPase subunit interface; other site 1048689013915 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048689013916 dimer interface [polypeptide binding]; other site 1048689013917 conserved gate region; other site 1048689013918 putative PBP binding loops; other site 1048689013919 ABC-ATPase subunit interface; other site 1048689013920 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 1048689013921 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 1048689013922 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1048689013923 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 1048689013924 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1048689013925 Walker A/P-loop; other site 1048689013926 ATP binding site [chemical binding]; other site 1048689013927 Q-loop/lid; other site 1048689013928 ABC transporter signature motif; other site 1048689013929 Walker B; other site 1048689013930 D-loop; other site 1048689013931 H-loop/switch region; other site 1048689013932 TOBE domain; Region: TOBE_2; pfam08402 1048689013933 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1048689013934 trimer interface; other site 1048689013935 sugar binding site [chemical binding]; other site 1048689013936 maltose regulon periplasmic protein; Provisional; Region: PRK10564 1048689013937 hypothetical protein; Validated; Region: PRK09718 1048689013938 SopA-like central domain; Region: SopA; pfam13981 1048689013939 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 1048689013940 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 1048689013941 UbiA prenyltransferase family; Region: UbiA; pfam01040 1048689013942 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 1048689013943 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1048689013944 putative acyl-acceptor binding pocket; other site 1048689013945 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1048689013946 LexA repressor; Validated; Region: PRK00215 1048689013947 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1048689013948 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1048689013949 Catalytic site [active] 1048689013950 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 1048689013951 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1048689013952 hypothetical protein; Provisional; Region: PRK10428 1048689013953 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1048689013954 metal binding site 2 [ion binding]; metal-binding site 1048689013955 putative DNA binding helix; other site 1048689013956 metal binding site 1 [ion binding]; metal-binding site 1048689013957 dimer interface [polypeptide binding]; other site 1048689013958 structural Zn2+ binding site [ion binding]; other site 1048689013959 Protein of unknown function (DUF2713); Region: DUF2713; pfam10897 1048689013960 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 1048689013961 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1048689013962 FMN binding site [chemical binding]; other site 1048689013963 active site 1048689013964 catalytic residues [active] 1048689013965 substrate binding site [chemical binding]; other site 1048689013966 phage shock protein G; Reviewed; Region: pspG; PRK09459 1048689013967 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1048689013968 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1048689013969 NADP binding site [chemical binding]; other site 1048689013970 dimer interface [polypeptide binding]; other site 1048689013971 replicative DNA helicase; Provisional; Region: PRK08006 1048689013972 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1048689013973 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1048689013974 Walker A motif; other site 1048689013975 ATP binding site [chemical binding]; other site 1048689013976 Walker B motif; other site 1048689013977 DNA binding loops [nucleotide binding] 1048689013978 alanine racemase; Reviewed; Region: alr; PRK00053 1048689013979 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1048689013980 active site 1048689013981 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1048689013982 substrate binding site [chemical binding]; other site 1048689013983 catalytic residues [active] 1048689013984 dimer interface [polypeptide binding]; other site 1048689013985 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1048689013986 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1048689013987 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048689013988 homodimer interface [polypeptide binding]; other site 1048689013989 catalytic residue [active] 1048689013990 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1048689013991 active site 1048689013992 motif I; other site 1048689013993 motif II; other site 1048689013994 secondary thiamine-phosphate synthase enzyme; Region: TIGR00149_YjbQ 1048689013995 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 1048689013996 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1048689013997 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1048689013998 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1048689013999 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1048689014000 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1048689014001 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1048689014002 dimer interface [polypeptide binding]; other site 1048689014003 ssDNA binding site [nucleotide binding]; other site 1048689014004 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1048689014005 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 1048689014006 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 1048689014007 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1048689014008 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1048689014009 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 1048689014010 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1048689014011 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 1048689014012 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 1048689014013 DNA binding residues [nucleotide binding] 1048689014014 dimer interface [polypeptide binding]; other site 1048689014015 [2Fe-2S] cluster binding site [ion binding]; other site 1048689014016 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1048689014017 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1048689014018 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1048689014019 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1048689014020 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1048689014021 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1048689014022 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1048689014023 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1048689014024 Na binding site [ion binding]; other site 1048689014025 Predicted membrane protein [Function unknown]; Region: COG3162 1048689014026 acetyl-CoA synthetase; Provisional; Region: PRK00174 1048689014027 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1048689014028 active site 1048689014029 CoA binding site [chemical binding]; other site 1048689014030 acyl-activating enzyme (AAE) consensus motif; other site 1048689014031 AMP binding site [chemical binding]; other site 1048689014032 acetate binding site [chemical binding]; other site 1048689014033 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 1048689014034 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 1048689014035 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 1048689014036 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 1048689014037 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 1048689014038 heme lyase subunit NrfE; Provisional; Region: PRK10369 1048689014039 formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144 1048689014040 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 1048689014041 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1048689014042 binding surface 1048689014043 TPR motif; other site 1048689014044 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 1048689014045 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1048689014046 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1048689014047 Sel1-like repeats; Region: SEL1; smart00671 1048689014048 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1048689014049 molybdopterin cofactor binding site; other site 1048689014050 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 1048689014051 molybdopterin cofactor binding site; other site 1048689014052 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1048689014053 putative outer membrane efflux protein MdtP; Provisional; Region: PRK09915 1048689014054 multidrug efflux system protein MdtO; Provisional; Region: PRK11427 1048689014055 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1048689014056 multidrug resistance protein MdtN; Provisional; Region: PRK10476 1048689014057 multidrug resistance protein MdtN; Provisional; Region: PRK10476 1048689014058 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1048689014059 HlyD family secretion protein; Region: HlyD_3; pfam13437 1048689014060 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 1048689014061 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1048689014062 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1048689014063 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1048689014064 active site 1048689014065 phosphorylation site [posttranslational modification] 1048689014066 intermolecular recognition site; other site 1048689014067 dimerization interface [polypeptide binding]; other site 1048689014068 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1048689014069 DNA binding site [nucleotide binding] 1048689014070 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 1048689014071 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1048689014072 substrate binding site [chemical binding]; other site 1048689014073 ATP binding site [chemical binding]; other site 1048689014074 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1048689014075 intersubunit interface [polypeptide binding]; other site 1048689014076 active site 1048689014077 zinc binding site [ion binding]; other site 1048689014078 Na+ binding site [ion binding]; other site 1048689014079 Protein of unknown function (DUF1498); Region: DUF1498; pfam07385 1048689014080 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 1048689014081 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1048689014082 putative ligand binding site [chemical binding]; other site 1048689014083 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1048689014084 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1048689014085 TM-ABC transporter signature motif; other site 1048689014086 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1048689014087 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1048689014088 Walker A/P-loop; other site 1048689014089 ATP binding site [chemical binding]; other site 1048689014090 Q-loop/lid; other site 1048689014091 ABC transporter signature motif; other site 1048689014092 Walker B; other site 1048689014093 D-loop; other site 1048689014094 H-loop/switch region; other site 1048689014095 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1048689014096 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1048689014097 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1048689014098 dimerization interface [polypeptide binding]; other site 1048689014099 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1048689014100 dimer interface [polypeptide binding]; other site 1048689014101 phosphorylation site [posttranslational modification] 1048689014102 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1048689014103 ATP binding site [chemical binding]; other site 1048689014104 Mg2+ binding site [ion binding]; other site 1048689014105 G-X-G motif; other site 1048689014106 Response regulator receiver domain; Region: Response_reg; pfam00072 1048689014107 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1048689014108 active site 1048689014109 phosphorylation site [posttranslational modification] 1048689014110 intermolecular recognition site; other site 1048689014111 dimerization interface [polypeptide binding]; other site 1048689014112 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 1048689014113 putative hydrolase; Provisional; Region: PRK02113 1048689014114 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1048689014115 Coenzyme A binding pocket [chemical binding]; other site 1048689014116 ribose 1,5-bisphosphokinase; Provisional; Region: PRK10078 1048689014117 AAA domain; Region: AAA_18; pfam13238 1048689014118 active site 1048689014119 Metal-dependent hydrolase involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3454 1048689014120 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1048689014121 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 1048689014122 active site 1048689014123 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 1048689014124 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1048689014125 Walker A/P-loop; other site 1048689014126 ATP binding site [chemical binding]; other site 1048689014127 Q-loop/lid; other site 1048689014128 ABC transporter signature motif; other site 1048689014129 Walker B; other site 1048689014130 D-loop; other site 1048689014131 H-loop/switch region; other site 1048689014132 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 1048689014133 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1048689014134 Walker A/P-loop; other site 1048689014135 ATP binding site [chemical binding]; other site 1048689014136 Q-loop/lid; other site 1048689014137 ABC transporter signature motif; other site 1048689014138 Walker B; other site 1048689014139 D-loop; other site 1048689014140 H-loop/switch region; other site 1048689014141 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1048689014142 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 1048689014143 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnI; COG3626 1048689014144 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnH; COG3625 1048689014145 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 1048689014146 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 1048689014147 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1048689014148 DNA-binding site [nucleotide binding]; DNA binding site 1048689014149 UTRA domain; Region: UTRA; pfam07702 1048689014150 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 1048689014151 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048689014152 dimer interface [polypeptide binding]; other site 1048689014153 conserved gate region; other site 1048689014154 putative PBP binding loops; other site 1048689014155 ABC-ATPase subunit interface; other site 1048689014156 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 1048689014157 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1048689014158 substrate binding pocket [chemical binding]; other site 1048689014159 membrane-bound complex binding site; other site 1048689014160 hinge residues; other site 1048689014161 phosphonate/organophosphate ester transporter subunit; Provisional; Region: PRK09984 1048689014162 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 1048689014163 Walker A/P-loop; other site 1048689014164 ATP binding site [chemical binding]; other site 1048689014165 Q-loop/lid; other site 1048689014166 ABC transporter signature motif; other site 1048689014167 Walker B; other site 1048689014168 D-loop; other site 1048689014169 H-loop/switch region; other site 1048689014170 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1048689014171 dimer interface [polypeptide binding]; other site 1048689014172 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1048689014173 hypothetical protein; Provisional; Region: PRK10220 1048689014174 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1048689014175 PhnA protein; Region: PhnA; pfam03831 1048689014176 hypothetical protein; Provisional; Region: PRK09866 1048689014177 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1048689014178 G1 box; other site 1048689014179 GTP/Mg2+ binding site [chemical binding]; other site 1048689014180 G2 box; other site 1048689014181 Switch I region; other site 1048689014182 G3 box; other site 1048689014183 Switch II region; other site 1048689014184 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1048689014185 G2 box; other site 1048689014186 Switch I region; other site 1048689014187 G3 box; other site 1048689014188 Switch II region; other site 1048689014189 G4 box; other site 1048689014190 G5 box; other site 1048689014191 YjcZ-like protein; Region: YjcZ; pfam13990 1048689014192 proline/glycine betaine transporter; Provisional; Region: PRK10642 1048689014193 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689014194 putative substrate translocation pore; other site 1048689014195 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 1048689014196 sensor protein BasS/PmrB; Provisional; Region: PRK10755 1048689014197 HAMP domain; Region: HAMP; pfam00672 1048689014198 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1048689014199 dimer interface [polypeptide binding]; other site 1048689014200 phosphorylation site [posttranslational modification] 1048689014201 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1048689014202 ATP binding site [chemical binding]; other site 1048689014203 Mg2+ binding site [ion binding]; other site 1048689014204 G-X-G motif; other site 1048689014205 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 1048689014206 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1048689014207 active site 1048689014208 phosphorylation site [posttranslational modification] 1048689014209 intermolecular recognition site; other site 1048689014210 dimerization interface [polypeptide binding]; other site 1048689014211 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1048689014212 DNA binding site [nucleotide binding] 1048689014213 putative metal dependent hydrolase; Provisional; Region: PRK11598 1048689014214 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1048689014215 Sulfatase; Region: Sulfatase; pfam00884 1048689014216 arginine:agmatin antiporter; Provisional; Region: PRK10644 1048689014217 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1048689014218 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1048689014219 arginine decarboxylase; Provisional; Region: PRK15029 1048689014220 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1048689014221 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1048689014222 homodimer interface [polypeptide binding]; other site 1048689014223 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048689014224 catalytic residue [active] 1048689014225 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1048689014226 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 1048689014227 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1048689014228 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1048689014229 alpha-galactosidase; Provisional; Region: PRK15076 1048689014230 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 1048689014231 NAD binding site [chemical binding]; other site 1048689014232 sugar binding site [chemical binding]; other site 1048689014233 divalent metal binding site [ion binding]; other site 1048689014234 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1048689014235 dimer interface [polypeptide binding]; other site 1048689014236 melibiose:sodium symporter; Provisional; Region: PRK10429 1048689014237 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1048689014238 hypothetical protein; Provisional; Region: PRK09867 1048689014239 fumarate hydratase; Provisional; Region: PRK15389 1048689014240 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 1048689014241 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1048689014242 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1048689014243 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 1048689014244 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 1048689014245 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1048689014246 active site 1048689014247 phosphorylation site [posttranslational modification] 1048689014248 intermolecular recognition site; other site 1048689014249 dimerization interface [polypeptide binding]; other site 1048689014250 Transcriptional regulator; Region: CitT; pfam12431 1048689014251 sensory histidine kinase DcuS; Provisional; Region: PRK11086 1048689014252 PAS domain; Region: PAS; smart00091 1048689014253 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1048689014254 ATP binding site [chemical binding]; other site 1048689014255 Mg2+ binding site [ion binding]; other site 1048689014256 G-X-G motif; other site 1048689014257 Uncharacterized conserved protein [Function unknown]; Region: COG3592 1048689014258 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1048689014259 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 1048689014260 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 1048689014261 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 1048689014262 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1048689014263 dimer interface [polypeptide binding]; other site 1048689014264 putative anticodon binding site; other site 1048689014265 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1048689014266 motif 1; other site 1048689014267 active site 1048689014268 motif 2; other site 1048689014269 motif 3; other site 1048689014270 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1048689014271 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689014272 putative substrate translocation pore; other site 1048689014273 POT family; Region: PTR2; pfam00854 1048689014274 lysine decarboxylase CadA; Provisional; Region: PRK15400 1048689014275 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1048689014276 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1048689014277 homodimer interface [polypeptide binding]; other site 1048689014278 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048689014279 catalytic residue [active] 1048689014280 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1048689014281 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 1048689014282 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 1048689014283 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1048689014284 DNA binding site [nucleotide binding] 1048689014285 putative transcriptional regulator; Provisional; Region: PRK11640 1048689014286 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1048689014287 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 1048689014288 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 1048689014289 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1048689014290 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1048689014291 DsbD alpha interface [polypeptide binding]; other site 1048689014292 catalytic residues [active] 1048689014293 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 1048689014294 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1048689014295 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 1048689014296 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1048689014297 Aspartase; Region: Aspartase; cd01357 1048689014298 active sites [active] 1048689014299 tetramer interface [polypeptide binding]; other site 1048689014300 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 1048689014301 putative transporter; Provisional; Region: PRK11021 1048689014302 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1048689014303 oligomerisation interface [polypeptide binding]; other site 1048689014304 mobile loop; other site 1048689014305 roof hairpin; other site 1048689014306 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1048689014307 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1048689014308 ring oligomerisation interface [polypeptide binding]; other site 1048689014309 ATP/Mg binding site [chemical binding]; other site 1048689014310 stacking interactions; other site 1048689014311 hinge regions; other site 1048689014312 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 1048689014313 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 1048689014314 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1048689014315 FeS/SAM binding site; other site 1048689014316 elongation factor P; Validated; Region: PRK00529 1048689014317 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1048689014318 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1048689014319 RNA binding site [nucleotide binding]; other site 1048689014320 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1048689014321 RNA binding site [nucleotide binding]; other site 1048689014322 entericidin A; Provisional; Region: PRK09810 1048689014323 entericidin B membrane lipoprotein; Provisional; Region: PRK10081 1048689014324 multidrug efflux system protein; Provisional; Region: PRK11431 1048689014325 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 1048689014326 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 1048689014327 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 1048689014328 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1048689014329 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 1048689014330 Iron-sulfur protein interface; other site 1048689014331 proximal quinone binding site [chemical binding]; other site 1048689014332 C-subunit interface; other site 1048689014333 distal quinone binding site; other site 1048689014334 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 1048689014335 D-subunit interface [polypeptide binding]; other site 1048689014336 Iron-sulfur protein interface; other site 1048689014337 proximal quinone binding site [chemical binding]; other site 1048689014338 distal quinone binding site [chemical binding]; other site 1048689014339 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 1048689014340 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1048689014341 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 1048689014342 L-aspartate oxidase; Provisional; Region: PRK06175 1048689014343 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1048689014344 poxB regulator PoxA; Provisional; Region: PRK09350 1048689014345 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1048689014346 motif 1; other site 1048689014347 dimer interface [polypeptide binding]; other site 1048689014348 active site 1048689014349 motif 2; other site 1048689014350 motif 3; other site 1048689014351 inner membrane transporter YjeM; Provisional; Region: PRK15238 1048689014352 putative mechanosensitive channel protein; Provisional; Region: PRK10929 1048689014353 linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated...; Region: H15; cl00073 1048689014354 DNA-binding site [nucleotide binding]; DNA binding site 1048689014355 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 1048689014356 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1048689014357 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 1048689014358 GTPase RsgA; Reviewed; Region: PRK12288 1048689014359 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1048689014360 RNA binding site [nucleotide binding]; other site 1048689014361 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1048689014362 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1048689014363 GTP/Mg2+ binding site [chemical binding]; other site 1048689014364 G4 box; other site 1048689014365 G5 box; other site 1048689014366 G1 box; other site 1048689014367 Switch I region; other site 1048689014368 G2 box; other site 1048689014369 G3 box; other site 1048689014370 Switch II region; other site 1048689014371 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1048689014372 catalytic site [active] 1048689014373 putative active site [active] 1048689014374 putative substrate binding site [chemical binding]; other site 1048689014375 dimer interface [polypeptide binding]; other site 1048689014376 epoxyqueuosine reductase; Region: TIGR00276 1048689014377 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1048689014378 putative carbohydrate kinase; Provisional; Region: PRK10565 1048689014379 yjeF N-terminal region; Region: yjeF_nterm; TIGR00197 1048689014380 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1048689014381 putative substrate binding site [chemical binding]; other site 1048689014382 putative ATP binding site [chemical binding]; other site 1048689014383 ADP-binding protein; Provisional; Region: PRK10646 1048689014384 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 1048689014385 AMIN domain; Region: AMIN; pfam11741 1048689014386 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1048689014387 active site 1048689014388 metal binding site [ion binding]; metal-binding site 1048689014389 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1048689014390 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1048689014391 ATP binding site [chemical binding]; other site 1048689014392 Mg2+ binding site [ion binding]; other site 1048689014393 G-X-G motif; other site 1048689014394 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 1048689014395 ATP binding site [chemical binding]; other site 1048689014396 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1048689014397 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1048689014398 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1048689014399 bacterial Hfq-like; Region: Hfq; cd01716 1048689014400 hexamer interface [polypeptide binding]; other site 1048689014401 Sm1 motif; other site 1048689014402 RNA binding site [nucleotide binding]; other site 1048689014403 Sm2 motif; other site 1048689014404 GTPase HflX; Provisional; Region: PRK11058 1048689014405 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1048689014406 HflX GTPase family; Region: HflX; cd01878 1048689014407 G1 box; other site 1048689014408 GTP/Mg2+ binding site [chemical binding]; other site 1048689014409 Switch I region; other site 1048689014410 G2 box; other site 1048689014411 G3 box; other site 1048689014412 Switch II region; other site 1048689014413 G4 box; other site 1048689014414 G5 box; other site 1048689014415 FtsH protease regulator HflK; Provisional; Region: PRK10930 1048689014416 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 1048689014417 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 1048689014418 FtsH protease regulator HflC; Provisional; Region: PRK11029 1048689014419 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1048689014420 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 1048689014421 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1048689014422 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1048689014423 GDP-binding site [chemical binding]; other site 1048689014424 ACT binding site; other site 1048689014425 IMP binding site; other site 1048689014426 Predicted transcriptional regulator [Transcription]; Region: COG1959 1048689014427 transcriptional repressor NsrR; Provisional; Region: PRK11014 1048689014428 exoribonuclease R; Provisional; Region: PRK11642 1048689014429 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 1048689014430 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1048689014431 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1048689014432 RNB domain; Region: RNB; pfam00773 1048689014433 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1048689014434 RNA binding site [nucleotide binding]; other site 1048689014435 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 1048689014436 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1048689014437 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1048689014438 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3789 1048689014439 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1048689014440 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 1048689014441 Predicted membrane protein [Function unknown]; Region: COG3766 1048689014442 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1048689014443 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1048689014444 Predicted integral membrane protein [Function unknown]; Region: COG5463 1048689014445 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1048689014446 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 1048689014447 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 1048689014448 FAD binding site [chemical binding]; other site 1048689014449 substrate binding site [chemical binding]; other site 1048689014450 catalytic residues [active] 1048689014451 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1048689014452 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 1048689014453 esterase; Provisional; Region: PRK10566 1048689014454 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1048689014455 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1048689014456 transcriptional repressor UlaR; Provisional; Region: PRK13509 1048689014457 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1048689014458 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1048689014459 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 1048689014460 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1048689014461 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 1048689014462 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 1048689014463 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1048689014464 active site 1048689014465 P-loop; other site 1048689014466 phosphorylation site [posttranslational modification] 1048689014467 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1048689014468 active site 1048689014469 phosphorylation site [posttranslational modification] 1048689014470 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1048689014471 active site 1048689014472 dimer interface [polypeptide binding]; other site 1048689014473 magnesium binding site [ion binding]; other site 1048689014474 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 1048689014475 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1048689014476 AP (apurinic/apyrimidinic) site pocket; other site 1048689014477 DNA interaction; other site 1048689014478 Metal-binding active site; metal-binding site 1048689014479 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1048689014480 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1048689014481 intersubunit interface [polypeptide binding]; other site 1048689014482 active site 1048689014483 Zn2+ binding site [ion binding]; other site 1048689014484 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1048689014485 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1048689014486 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1048689014487 dimer interface [polypeptide binding]; other site 1048689014488 ssDNA binding site [nucleotide binding]; other site 1048689014489 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1048689014490 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1048689014491 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1048689014492 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1048689014493 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1048689014494 Protein of unknown function (DUF2686); Region: DUF2686; pfam10887 1048689014495 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1048689014496 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1048689014497 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1048689014498 Probable transposase; Region: OrfB_IS605; pfam01385 1048689014499 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1048689014500 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 1048689014501 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 1048689014502 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 1048689014503 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1048689014504 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1048689014505 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1048689014506 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 1048689014507 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 1048689014508 Hemerythrin-like domain; Region: Hr-like; cd12108 1048689014509 Fe binding site [ion binding]; other site 1048689014510 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1048689014511 EamA-like transporter family; Region: EamA; pfam00892 1048689014512 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1048689014513 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1048689014514 NADP binding site [chemical binding]; other site 1048689014515 Predicted transcriptional regulators [Transcription]; Region: COG1733 1048689014516 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1048689014517 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 1048689014518 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1048689014519 active site 1048689014520 metal binding site [ion binding]; metal-binding site 1048689014521 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1048689014522 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1048689014523 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1048689014524 active site 1048689014525 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 1048689014526 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 1048689014527 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1048689014528 Domain of unknown function DUF21; Region: DUF21; pfam01595 1048689014529 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1048689014530 Transporter associated domain; Region: CorC_HlyC; smart01091 1048689014531 methionine sulfoxide reductase A; Provisional; Region: PRK00058 1048689014532 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 1048689014533 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1048689014534 Surface antigen; Region: Bac_surface_Ag; pfam01103 1048689014535 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 1048689014536 Family of unknown function (DUF490); Region: DUF490; pfam04357 1048689014537 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1048689014538 putative active site pocket [active] 1048689014539 dimerization interface [polypeptide binding]; other site 1048689014540 putative catalytic residue [active] 1048689014541 hypothetical protein; Provisional; Region: PRK09719 1048689014542 antitoxin ChpS; Provisional; Region: PRK11347 1048689014543 toxin ChpB; Provisional; Region: PRK09812 1048689014544 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1048689014545 dimer interface [polypeptide binding]; other site 1048689014546 substrate binding site [chemical binding]; other site 1048689014547 metal binding sites [ion binding]; metal-binding site 1048689014548 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 1048689014549 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1048689014550 putative ligand binding site [chemical binding]; other site 1048689014551 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1048689014552 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1048689014553 Walker A/P-loop; other site 1048689014554 ATP binding site [chemical binding]; other site 1048689014555 Q-loop/lid; other site 1048689014556 ABC transporter signature motif; other site 1048689014557 Walker B; other site 1048689014558 D-loop; other site 1048689014559 H-loop/switch region; other site 1048689014560 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1048689014561 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1048689014562 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1048689014563 TM-ABC transporter signature motif; other site 1048689014564 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1048689014565 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1048689014566 TM-ABC transporter signature motif; other site 1048689014567 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 1048689014568 AMP binding site [chemical binding]; other site 1048689014569 metal binding site [ion binding]; metal-binding site 1048689014570 active site 1048689014571 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 1048689014572 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1048689014573 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1048689014574 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1048689014575 hypothetical protein; Provisional; Region: PRK05255 1048689014576 peptidase PmbA; Provisional; Region: PRK11040 1048689014577 Cytochrome b562; Region: Cytochrom_B562; cl01546 1048689014578 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 1048689014579 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1048689014580 FeS/SAM binding site; other site 1048689014581 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 1048689014582 ATP cone domain; Region: ATP-cone; pfam03477 1048689014583 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1048689014584 effector binding site; other site 1048689014585 active site 1048689014586 Zn binding site [ion binding]; other site 1048689014587 glycine loop; other site 1048689014588 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 1048689014589 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1048689014590 Ca binding site [ion binding]; other site 1048689014591 active site 1048689014592 catalytic site [active] 1048689014593 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1048689014594 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 1048689014595 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1048689014596 active site turn [active] 1048689014597 phosphorylation site [posttranslational modification] 1048689014598 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1048689014599 trehalose repressor; Provisional; Region: treR; PRK09492 1048689014600 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1048689014601 DNA binding site [nucleotide binding] 1048689014602 domain linker motif; other site 1048689014603 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 1048689014604 dimerization interface [polypeptide binding]; other site 1048689014605 ligand binding site [chemical binding]; other site 1048689014606 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 1048689014607 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1048689014608 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1048689014609 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1048689014610 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1048689014611 motif II; other site 1048689014612 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1048689014613 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1048689014614 homotrimer interaction site [polypeptide binding]; other site 1048689014615 putative active site [active] 1048689014616 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 1048689014617 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 1048689014618 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 1048689014619 aspartate carbamoyltransferase; Region: asp_carb_tr; TIGR00670 1048689014620 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1048689014621 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1048689014622 PyrBI operon leader peptide; Region: PyrBI_leader; pfam08052 1048689014623 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 1048689014624 homotrimer interaction site [polypeptide binding]; other site 1048689014625 putative active site [active] 1048689014626 oxidoreductase; Provisional; Region: PRK12742 1048689014627 classical (c) SDRs; Region: SDR_c; cd05233 1048689014628 NAD(P) binding site [chemical binding]; other site 1048689014629 active site 1048689014630 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1048689014631 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1048689014632 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 1048689014633 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 1048689014634 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1048689014635 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1048689014636 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076 1048689014637 RNase E inhibitor protein; Provisional; Region: PRK11191 1048689014638 Predicted membrane protein [Function unknown]; Region: COG4269 1048689014639 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1048689014640 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1048689014641 HIGH motif; other site 1048689014642 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1048689014643 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1048689014644 active site 1048689014645 KMSKS motif; other site 1048689014646 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1048689014647 tRNA binding surface [nucleotide binding]; other site 1048689014648 anticodon binding site; other site 1048689014649 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1048689014650 DNA polymerase III subunit chi; Validated; Region: PRK05728 1048689014651 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1048689014652 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1048689014653 interface (dimer of trimers) [polypeptide binding]; other site 1048689014654 Substrate-binding/catalytic site; other site 1048689014655 Zn-binding sites [ion binding]; other site 1048689014656 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 1048689014657 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1048689014658 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 1048689014659 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1048689014660 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 1048689014661 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1048689014662 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1048689014663 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1048689014664 putative NAD(P) binding site [chemical binding]; other site 1048689014665 putative substrate binding site [chemical binding]; other site 1048689014666 catalytic Zn binding site [ion binding]; other site 1048689014667 structural Zn binding site [ion binding]; other site 1048689014668 dimer interface [polypeptide binding]; other site 1048689014669 potential protein location (hypothetical protein ECO55CA74_24435 [Escherichia coli O55:H7 str. RM12579]) that overlaps RNA (tRNA-L) 1048689014670 phage-like element CpLE4 1048689014671 integrase; Provisional; Region: PRK09692 1048689014672 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1048689014673 active site 1048689014674 Int/Topo IB signature motif; other site 1048689014675 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 1048689014676 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1048689014677 active site 1048689014678 catalytic residues [active] 1048689014679 DNA binding site [nucleotide binding] 1048689014680 Int/Topo IB signature motif; other site 1048689014681 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1048689014682 active site 1048689014683 catalytic residues [active] 1048689014684 DNA binding site [nucleotide binding] 1048689014685 Int/Topo IB signature motif; other site 1048689014686 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4688 1048689014687 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 1048689014688 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1048689014689 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1048689014690 phage-like element CpLE5 1048689014691 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1048689014692 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 1048689014693 HNH endonuclease; Region: HNH_2; pfam13391 1048689014694 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3055 1048689014695 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1048689014696 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1048689014697 active site 1048689014698 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1048689014699 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1048689014700 ligand binding site [chemical binding]; other site 1048689014701 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 1048689014702 Capsid triplex subunit 2; Provisional; Region: PHA03259 1048689014703 potential frameshift: common BLAST hit: gi|209400597|ref|YP_002273826.1| DEAD/DEAH box helicase domain protein 1048689014704 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1048689014705 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1048689014706 ATP binding site [chemical binding]; other site 1048689014707 putative Mg++ binding site [ion binding]; other site 1048689014708 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1048689014709 nucleotide binding region [chemical binding]; other site 1048689014710 ATP-binding site [chemical binding]; other site 1048689014711 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 1048689014712 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 1048689014713 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1048689014714 ATP binding site [chemical binding]; other site 1048689014715 putative Mg++ binding site [ion binding]; other site 1048689014716 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1048689014717 ATP-binding site [chemical binding]; other site 1048689014718 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1048689014719 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1048689014720 Part of AAA domain; Region: AAA_19; pfam13245 1048689014721 Family description; Region: UvrD_C_2; pfam13538 1048689014722 Domain of unknown function (DUF303); Region: DUF303; pfam03629 1048689014723 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 1048689014724 Kelch motif; Region: Kelch_1; pfam01344 1048689014725 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 1048689014726 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 1048689014727 Int/Topo IB signature motif; other site 1048689014728 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 1048689014729 Int/Topo IB signature motif; other site 1048689014730 Fimbrial protein; Region: Fimbrial; cl01416 1048689014731 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1048689014732 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 1048689014733 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1048689014734 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1048689014735 outer membrane usher protein; Provisional; Region: PRK15193 1048689014736 PapC N-terminal domain; Region: PapC_N; pfam13954 1048689014737 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1048689014738 PapC C-terminal domain; Region: PapC_C; pfam13953 1048689014739 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1048689014740 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1048689014741 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 1048689014742 mannosyl binding site [chemical binding]; other site 1048689014743 Fimbrial protein; Region: Fimbrial; pfam00419 1048689014744 fructuronate transporter; Provisional; Region: PRK10034 1048689014745 gluconate transporter; Region: gntP; TIGR00791 1048689014746 mannonate dehydratase; Region: uxuA; TIGR00695 1048689014747 mannonate dehydratase; Provisional; Region: PRK03906 1048689014748 D-mannonate oxidoreductase; Provisional; Region: PRK15037 1048689014749 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1048689014750 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1048689014751 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 1048689014752 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1048689014753 DNA-binding site [nucleotide binding]; DNA binding site 1048689014754 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1048689014755 Protein of unknown function (DUF2686); Region: DUF2686; pfam10887 1048689014756 DNA replication/recombination/repair protein; Provisional; Region: iraD; PRK14128 1048689014757 cell density-dependent motility repressor; Provisional; Region: PRK10082 1048689014758 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1048689014759 Isoaspartyl dipeptidase hydrolyzes the beta-L-isoaspartyl linkages in dipeptides, as part of the degradative pathway to eliminate proteins with beta-L-isoaspartyl peptide bonds, bonds whereby the beta-group of an aspartate forms the peptide link with the...; Region: Isoaspartyl-dipeptidase; cd01308 1048689014760 isoaspartyl dipeptidase IadA; Region: isoAsp_dipep; TIGR01975 1048689014761 dimer interface [polypeptide binding]; other site 1048689014762 active site 1048689014763 hypothetical protein; Provisional; Region: PRK10519 1048689014764 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 1048689014765 Nucleoside recognition; Region: Gate; pfam07670 1048689014766 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 1048689014767 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 1048689014768 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 1048689014769 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1048689014770 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1048689014771 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1048689014772 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1048689014773 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1048689014774 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1048689014775 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1048689014776 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1048689014777 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 1048689014778 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1048689014779 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689014780 putative substrate translocation pore; other site 1048689014781 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204 1048689014782 SdiA-regulated; Region: SdiA-regulated; cd09971 1048689014783 putative active site [active] 1048689014784 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1048689014785 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1048689014786 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1048689014787 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1048689014788 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1048689014789 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1048689014790 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 1048689014791 CoA-substrate-specific enzyme activase, putative; Region: CoA_E_activ; TIGR00241 1048689014792 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 1048689014793 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 1048689014794 Predicted membrane protein [Function unknown]; Region: COG2733 1048689014795 multidrug efflux system protein MdtM; Provisional; Region: PRK15403 1048689014796 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689014797 putative substrate translocation pore; other site 1048689014798 putative transposase; Provisional; Region: PRK09857 1048689014799 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1048689014800 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1048689014801 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1048689014802 DNA-binding site [nucleotide binding]; DNA binding site 1048689014803 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1048689014804 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048689014805 homodimer interface [polypeptide binding]; other site 1048689014806 catalytic residue [active] 1048689014807 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 1048689014808 endoribonuclease SymE; Provisional; Region: PRK13605 1048689014809 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 1048689014810 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1048689014811 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1048689014812 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1048689014813 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1048689014814 S-adenosylmethionine binding site [chemical binding]; other site 1048689014815 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 1048689014816 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 1048689014817 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1048689014818 ATP binding site [chemical binding]; other site 1048689014819 putative Mg++ binding site [ion binding]; other site 1048689014820 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 1048689014821 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 1048689014822 P-loop, Walker A motif; other site 1048689014823 Base recognition motif; other site 1048689014824 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1048689014825 Uncharacterized small protein [Function unknown]; Region: COG2879 1048689014826 carbon starvation protein A; Provisional; Region: PRK15015 1048689014827 Carbon starvation protein CstA; Region: CstA; pfam02554 1048689014828 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1048689014829 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 1048689014830 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1048689014831 dimer interface [polypeptide binding]; other site 1048689014832 ligand binding site [chemical binding]; other site 1048689014833 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1048689014834 dimerization interface [polypeptide binding]; other site 1048689014835 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1048689014836 dimer interface [polypeptide binding]; other site 1048689014837 putative CheW interface [polypeptide binding]; other site 1048689014838 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048689014839 D-galactonate transporter; Region: 2A0114; TIGR00893 1048689014840 putative substrate translocation pore; other site 1048689014841 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1048689014842 DNA-binding site [nucleotide binding]; DNA binding site 1048689014843 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1048689014844 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1048689014845 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1048689014846 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1048689014847 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 1048689014848 putative NAD(P) binding site [chemical binding]; other site 1048689014849 catalytic Zn binding site [ion binding]; other site 1048689014850 structural Zn binding site [ion binding]; other site 1048689014851 phosphoglycerol transferase I; Provisional; Region: PRK03776 1048689014852 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1048689014853 hypothetical protein; Provisional; Region: PRK11667 1048689014854 DNA replication protein DnaC; Validated; Region: PRK07952 1048689014855 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1048689014856 Walker A motif; other site 1048689014857 ATP binding site [chemical binding]; other site 1048689014858 Walker B motif; other site 1048689014859 primosomal protein DnaI; Provisional; Region: PRK02854 1048689014860 hypothetical protein; Provisional; Region: PRK09917 1048689014861 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1048689014862 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1048689014863 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1048689014864 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1048689014865 DNA binding residues [nucleotide binding] 1048689014866 dimerization interface [polypeptide binding]; other site 1048689014867 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 1048689014868 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1048689014869 DNA binding residues [nucleotide binding] 1048689014870 dimerization interface [polypeptide binding]; other site 1048689014871 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 1048689014872 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1048689014873 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1048689014874 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 1048689014875 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 1048689014876 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 1048689014877 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1048689014878 S-adenosylmethionine binding site [chemical binding]; other site 1048689014879 DNA polymerase III subunit psi; Validated; Region: PRK06856 1048689014880 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 1048689014881 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1048689014882 Coenzyme A binding pocket [chemical binding]; other site 1048689014883 dUMP phosphatase; Provisional; Region: PRK09449 1048689014884 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1048689014885 motif II; other site 1048689014886 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1048689014887 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1048689014888 G1 box; other site 1048689014889 putative GEF interaction site [polypeptide binding]; other site 1048689014890 GTP/Mg2+ binding site [chemical binding]; other site 1048689014891 Switch I region; other site 1048689014892 G2 box; other site 1048689014893 G3 box; other site 1048689014894 Switch II region; other site 1048689014895 G4 box; other site 1048689014896 G5 box; other site 1048689014897 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1048689014898 periplasmic protein; Provisional; Region: PRK10568 1048689014899 BON domain; Region: BON; pfam04972 1048689014900 BON domain; Region: BON; pfam04972 1048689014901 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 1048689014902 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 1048689014903 active site 1048689014904 nucleophile elbow; other site 1048689014905 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1048689014906 active site 1048689014907 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 1048689014908 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1048689014909 FeS/SAM binding site; other site 1048689014910 hypothetical protein; Provisional; Region: PRK10977 1048689014911 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1048689014912 intersubunit interface [polypeptide binding]; other site 1048689014913 active site 1048689014914 catalytic residue [active] 1048689014915 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 1048689014916 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1048689014917 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1048689014918 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1048689014919 phosphopentomutase; Provisional; Region: PRK05362 1048689014920 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1048689014921 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1048689014922 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1048689014923 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1048689014924 non-specific DNA binding site [nucleotide binding]; other site 1048689014925 salt bridge; other site 1048689014926 sequence-specific DNA binding site [nucleotide binding]; other site 1048689014927 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 1048689014928 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1048689014929 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1048689014930 hypothetical protein; Provisional; Region: PRK11246 1048689014931 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 1048689014932 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1048689014933 motif II; other site 1048689014934 DNA repair protein RadA; Region: sms; TIGR00416 1048689014935 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1048689014936 Walker A motif/ATP binding site; other site 1048689014937 ATP binding site [chemical binding]; other site 1048689014938 Walker B motif; other site 1048689014939 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1048689014940 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1048689014941 non-specific DNA binding site [nucleotide binding]; other site 1048689014942 salt bridge; other site 1048689014943 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 1048689014944 sequence-specific DNA binding site [nucleotide binding]; other site 1048689014945 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 1048689014946 active site 1048689014947 (T/H)XGH motif; other site 1048689014948 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 1048689014949 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1048689014950 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1048689014951 Walker A/P-loop; other site 1048689014952 ATP binding site [chemical binding]; other site 1048689014953 Q-loop/lid; other site 1048689014954 ABC transporter signature motif; other site 1048689014955 Walker B; other site 1048689014956 D-loop; other site 1048689014957 H-loop/switch region; other site 1048689014958 ABC transporter; Region: ABC_tran_2; pfam12848 1048689014959 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1048689014960 lytic murein transglycosylase; Provisional; Region: PRK11619 1048689014961 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1048689014962 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1048689014963 catalytic residue [active] 1048689014964 Trp operon repressor; Provisional; Region: PRK01381 1048689014965 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 1048689014966 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1048689014967 catalytic core [active] 1048689014968 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 1048689014969 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1048689014970 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 1048689014971 hypothetical protein; Provisional; Region: PRK10756 1048689014972 CreA protein; Region: CreA; pfam05981 1048689014973 DNA-binding response regulator CreB; Provisional; Region: PRK11083 1048689014974 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1048689014975 active site 1048689014976 phosphorylation site [posttranslational modification] 1048689014977 intermolecular recognition site; other site 1048689014978 dimerization interface [polypeptide binding]; other site 1048689014979 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1048689014980 DNA binding site [nucleotide binding] 1048689014981 sensory histidine kinase CreC; Provisional; Region: PRK11100 1048689014982 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1048689014983 dimerization interface [polypeptide binding]; other site 1048689014984 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1048689014985 dimer interface [polypeptide binding]; other site 1048689014986 phosphorylation site [posttranslational modification] 1048689014987 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1048689014988 ATP binding site [chemical binding]; other site 1048689014989 Mg2+ binding site [ion binding]; other site 1048689014990 G-X-G motif; other site 1048689014991 Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452 1048689014992 two-component response regulator; Provisional; Region: PRK11173 1048689014993 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1048689014994 active site 1048689014995 phosphorylation site [posttranslational modification] 1048689014996 intermolecular recognition site; other site 1048689014997 dimerization interface [polypeptide binding]; other site 1048689014998 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1048689014999 DNA binding site [nucleotide binding] 1048689015000 putative RNA methyltransferase; Provisional; Region: PRK10433 1048689015001 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050 1048689015002 Antirestriction protein; Region: Antirestrict; pfam03230 1048689015003 Protein of unknown function (DUF1380); Region: DUF1380; pfam07128 1048689015004 Domain of unknown function (DUF932); Region: DUF932; pfam06067 1048689015005 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 1048689015006 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1048689015007 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1048689015008 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1048689015009 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1048689015010 catalytic residue [active] 1048689015011 TraM protein; Region: Tra_M; pfam05261 1048689015012 conjugal transfer transcriptional regulator TraJ; Provisional; Region: PRK13719 1048689015013 conjugal transfer protein TraY; Provisional; Region: PRK13740 1048689015014 TraY domain; Region: TraY; cl17675 1048689015015 conjugal transfer pilin subunit TraA; Provisional; Region: PRK13734 1048689015016 conjugal transfer pilus assembly protein TraL; Provisional; Region: PRK13707 1048689015017 conjugal transfer pilus assembly protein TraE; Provisional; Region: PRK13726 1048689015018 conjugal transfer protein TraK; Provisional; Region: PRK13736; cl05878 1048689015019 TraK protein; Region: TraK; pfam06586 1048689015020 conjugal transfer nickase/helicase TraI; Provisional; Region: PRK14712 1048689015021 conjugal transfer nickase/helicase TraI; Provisional; Region: PRK14712 1048689015022 conjugal transfer pilus acetylation protein TraX; Provisional; Region: PRK13706 1048689015023 conjugal transfer protein TrbP; Provisional; Region: PRK13882 1048689015024 conjugal transfer fertility inhibition protein FinO; Provisional; Region: PRK13754 1048689015025 Fertility inhibition protein N terminal; Region: FinO_N; pfam12602 1048689015026 FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cd00236 1048689015027 putative RNA binding sites [nucleotide binding]; other site 1048689015028 Staphylococcal nuclease homologues; Region: SNc; smart00318 1048689015029 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1048689015030 Catalytic site; other site 1048689015031 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1048689015032 Transposase; Region: HTH_Tnp_1; cl17663 1048689015033 Integrase core domain; Region: rve; pfam00665 1048689015034 Peptidase M66; Region: Peptidase_M66; pfam10462 1048689015035 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 1048689015036 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1048689015037 type II secretion system protein D; Region: type_II_gspD; TIGR02517 1048689015038 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1048689015039 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1048689015040 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1048689015041 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1048689015042 type II secretion system protein E; Region: type_II_gspE; TIGR02533 1048689015043 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1048689015044 Walker A motif; other site 1048689015045 ATP binding site [chemical binding]; other site 1048689015046 Walker B motif; other site 1048689015047 type II secretion system protein F; Region: GspF; TIGR02120 1048689015048 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1048689015049 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1048689015050 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1048689015051 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 1048689015052 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1048689015053 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 1048689015054 type II secretion system protein I; Region: gspI; TIGR01707 1048689015055 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 1048689015056 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 1048689015057 type II secretion system protein J; Region: gspJ; TIGR01711 1048689015058 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 1048689015059 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 1048689015060 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 1048689015061 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 1048689015062 GspL periplasmic domain; Region: GspL_C; pfam12693 1048689015063 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 1048689015064 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1048689015065 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1048689015066 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1048689015067 lipoprotein, PulS/OutS family; Region: PulS_OutS; TIGR01004 1048689015068 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1048689015069 replication protein; Provisional; Region: PRK13702 1048689015070 RelB antitoxin; Region: RelB; cl01171 1048689015071 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 1048689015072 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 1048689015073 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1048689015074 trimer interface [polypeptide binding]; other site 1048689015075 active site 1048689015076 substrate binding site [chemical binding]; other site 1048689015077 CoA binding site [chemical binding]; other site 1048689015078 FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cd00236 1048689015079 putative kissing complex interaction region; other site 1048689015080 putative RNA binding sites [nucleotide binding]; other site 1048689015081 Colicin Ia; Region: Colicin_Ia; pfam11504 1048689015082 Colicin pore forming domain; Region: Colicin; pfam01024 1048689015083 Colicin E1 (microcin) immunity protein; Region: Microcin; pfam03526 1048689015084 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1048689015085 Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient...; Region: SR_Res_par; cd03767 1048689015086 catalytic residues [active] 1048689015087 catalytic nucleophile [active] 1048689015088 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 1048689015089 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 1048689015090 Transposase; Region: HTH_Tnp_1; pfam01527 1048689015091 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1048689015092 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1048689015093 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1048689015094 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1048689015095 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1048689015096 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1048689015097 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1048689015098 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1048689015099 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 1048689015100 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1048689015101 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1048689015102 salt bridge; other site 1048689015103 non-specific DNA binding site [nucleotide binding]; other site 1048689015104 sequence-specific DNA binding site [nucleotide binding]; other site 1048689015105 Integrase core domain; Region: rve; pfam00665 1048689015106 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1048689015107 DNA binding site [nucleotide binding] 1048689015108 active site 1048689015109 Int/Topo IB signature motif; other site 1048689015110 putative transposase OrfB; Reviewed; Region: PHA02517 1048689015111 HTH-like domain; Region: HTH_21; pfam13276 1048689015112 Integrase core domain; Region: rve; pfam00665 1048689015113 Integrase core domain; Region: rve_3; pfam13683 1048689015114 Transposase; Region: HTH_Tnp_1; cl17663 1048689015115 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1048689015116 3-deoxy-D-manno-octulosonic-acid kinase; Reviewed; Region: PRK01723 1048689015117 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1048689015118 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1048689015119 active site 1048689015120 catalytic residues [active] 1048689015121 DNA binding site [nucleotide binding] 1048689015122 Int/Topo IB signature motif; other site 1048689015123 Integrase core domain; Region: rve; pfam00665 1048689015124 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1048689015125 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1048689015126 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1048689015127 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1048689015128 P-loop; other site 1048689015129 Magnesium ion binding site [ion binding]; other site 1048689015130 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1048689015131 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1048689015132 ParB-like nuclease domain; Region: ParB; smart00470 1048689015133 ParB family; Region: ParB; pfam08775 1048689015134 Y-family of DNA polymerases; Region: PolY; cl12025 1048689015135 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1048689015136 Y-family of DNA polymerases; Region: PolY; cl12025 1048689015137 putative methylase; Provisional; Region: PRK13699 1048689015138 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1048689015139 Protein of unknown function (DUF1380); Region: DUF1380; pfam07128 1048689015140 dihydropteroate synthase; Region: DHPS; TIGR01496 1048689015141 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1048689015142 substrate binding pocket [chemical binding]; other site 1048689015143 dimer interface [polypeptide binding]; other site 1048689015144 inhibitor binding site; inhibition site 1048689015145 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 1048689015146 Phosphotransferase enzyme family; Region: APH; pfam01636 1048689015147 active site 1048689015148 ATP binding site [chemical binding]; other site 1048689015149 antibiotic binding site [chemical binding]; other site 1048689015150 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; pfam04655 1048689015151 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 1048689015152 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877