-- dump date 20140619_090337 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1072459000001 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 1072459000002 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 1072459000003 putative catalytic residues [active] 1072459000004 putative nucleotide binding site [chemical binding]; other site 1072459000005 putative aspartate binding site [chemical binding]; other site 1072459000006 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 1072459000007 dimer interface [polypeptide binding]; other site 1072459000008 putative threonine allosteric regulatory site; other site 1072459000009 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 1072459000010 putative threonine allosteric regulatory site; other site 1072459000011 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1072459000012 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1072459000013 homoserine kinase; Region: thrB; TIGR00191 1072459000014 Protein of unknown function; Region: YhfT; pfam10797 1072459000015 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1072459000016 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1072459000017 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1072459000018 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1072459000019 catalytic residue [active] 1072459000020 hypothetical protein; Validated; Region: PRK02101 1072459000021 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1072459000022 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 1072459000023 transaldolase-like protein; Provisional; Region: PTZ00411 1072459000024 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1072459000025 active site 1072459000026 dimer interface [polypeptide binding]; other site 1072459000027 catalytic residue [active] 1072459000028 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1072459000029 MPT binding site; other site 1072459000030 trimer interface [polypeptide binding]; other site 1072459000031 hypothetical protein; Provisional; Region: PRK10659 1072459000032 hypothetical protein; Provisional; Region: PRK10236 1072459000033 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 1072459000034 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 1072459000035 hypothetical protein; Provisional; Region: PRK10154 1072459000036 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1072459000037 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 1072459000038 nucleotide binding site [chemical binding]; other site 1072459000039 NEF interaction site [polypeptide binding]; other site 1072459000040 SBD interface [polypeptide binding]; other site 1072459000041 chaperone protein DnaJ; Provisional; Region: PRK10767 1072459000042 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1072459000043 HSP70 interaction site [polypeptide binding]; other site 1072459000044 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1072459000045 substrate binding site [polypeptide binding]; other site 1072459000046 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1072459000047 Zn binding sites [ion binding]; other site 1072459000048 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1072459000049 dimer interface [polypeptide binding]; other site 1072459000050 Hok/gef family; Region: HOK_GEF; pfam01848 1072459000051 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; pfam03502 1072459000052 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1072459000053 Sulfatase; Region: Sulfatase; pfam00884 1072459000054 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 1072459000055 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 1072459000056 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 1072459000057 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1072459000058 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 1072459000059 putative dimerization interface [polypeptide binding]; other site 1072459000060 putative fimbrial assembly chaperone protein StcB; Provisional; Region: PRK15253 1072459000061 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1072459000062 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1072459000063 Fimbrial protein; Region: Fimbrial; cl01416 1072459000064 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1072459000065 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1072459000066 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1072459000067 active site 1072459000068 Riboflavin kinase; Region: Flavokinase; smart00904 1072459000069 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1072459000070 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1072459000071 HIGH motif; other site 1072459000072 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1072459000073 active site 1072459000074 KMSKS motif; other site 1072459000075 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1072459000076 tRNA binding surface [nucleotide binding]; other site 1072459000077 anticodon binding site; other site 1072459000078 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1072459000079 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1072459000080 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 1072459000081 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1072459000082 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1072459000083 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1072459000084 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1072459000085 active site 1072459000086 tetramer interface [polypeptide binding]; other site 1072459000087 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 1072459000088 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1072459000089 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1072459000090 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1072459000091 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1072459000092 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1072459000093 catalytic site [active] 1072459000094 subunit interface [polypeptide binding]; other site 1072459000095 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1072459000096 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1072459000097 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1072459000098 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1072459000099 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1072459000100 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1072459000101 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1072459000102 IMP binding site; other site 1072459000103 dimer interface [polypeptide binding]; other site 1072459000104 interdomain contacts; other site 1072459000105 partial ornithine binding site; other site 1072459000106 DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476 1072459000107 carnitine operon protein CaiE; Provisional; Region: PRK13627 1072459000108 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 1072459000109 putative trimer interface [polypeptide binding]; other site 1072459000110 putative metal binding site [ion binding]; other site 1072459000111 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 1072459000112 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1072459000113 substrate binding site [chemical binding]; other site 1072459000114 oxyanion hole (OAH) forming residues; other site 1072459000115 trimer interface [polypeptide binding]; other site 1072459000116 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 1072459000117 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 1072459000118 acyl-activating enzyme (AAE) consensus motif; other site 1072459000119 putative AMP binding site [chemical binding]; other site 1072459000120 putative active site [active] 1072459000121 putative CoA binding site [chemical binding]; other site 1072459000122 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 1072459000123 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1072459000124 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 1072459000125 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1072459000126 active site 1072459000127 L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356 1072459000128 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1072459000129 Ligand binding site [chemical binding]; other site 1072459000130 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1072459000131 putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363 1072459000132 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985 1072459000133 Ligand binding site [chemical binding]; other site 1072459000134 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1072459000135 putative oxidoreductase FixC; Provisional; Region: PRK10157 1072459000136 ferredoxin-like protein FixX; Provisional; Region: PRK15449 1072459000137 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 1072459000138 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 1072459000139 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 1072459000140 TrkA-N domain; Region: TrkA_N; pfam02254 1072459000141 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1072459000142 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1072459000143 folate binding site [chemical binding]; other site 1072459000144 NADP+ binding site [chemical binding]; other site 1072459000145 Post-segregation antitoxin CcdA; Region: CcdA; pfam07362 1072459000146 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 1072459000147 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 1072459000148 active site 1072459000149 metal binding site [ion binding]; metal-binding site 1072459000150 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 1072459000151 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1072459000152 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1072459000153 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 1072459000154 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1072459000155 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 1072459000156 SurA N-terminal domain; Region: SurA_N; pfam09312 1072459000157 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1072459000158 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1072459000159 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 1072459000160 OstA-like protein; Region: OstA; pfam03968 1072459000161 Organic solvent tolerance protein; Region: OstA_C; pfam04453 1072459000162 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 1072459000163 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 1072459000164 putative metal binding site [ion binding]; other site 1072459000165 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1072459000166 HSP70 interaction site [polypeptide binding]; other site 1072459000167 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1072459000168 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1072459000169 active site 1072459000170 ATP-dependent helicase HepA; Validated; Region: PRK04914 1072459000171 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1072459000172 ATP binding site [chemical binding]; other site 1072459000173 putative Mg++ binding site [ion binding]; other site 1072459000174 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1072459000175 nucleotide binding region [chemical binding]; other site 1072459000176 ATP-binding site [chemical binding]; other site 1072459000177 DNA polymerase II; Reviewed; Region: PRK05762 1072459000178 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 1072459000179 active site 1072459000180 catalytic site [active] 1072459000181 substrate binding site [chemical binding]; other site 1072459000182 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 1072459000183 active site 1072459000184 metal-binding site 1072459000185 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1072459000186 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1072459000187 intersubunit interface [polypeptide binding]; other site 1072459000188 active site 1072459000189 Zn2+ binding site [ion binding]; other site 1072459000190 L-arabinose isomerase; Provisional; Region: PRK02929 1072459000191 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 1072459000192 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 1072459000193 trimer interface [polypeptide binding]; other site 1072459000194 putative substrate binding site [chemical binding]; other site 1072459000195 putative metal binding site [ion binding]; other site 1072459000196 ribulokinase; Provisional; Region: PRK04123 1072459000197 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1072459000198 N- and C-terminal domain interface [polypeptide binding]; other site 1072459000199 active site 1072459000200 MgATP binding site [chemical binding]; other site 1072459000201 catalytic site [active] 1072459000202 metal binding site [ion binding]; metal-binding site 1072459000203 carbohydrate binding site [chemical binding]; other site 1072459000204 homodimer interface [polypeptide binding]; other site 1072459000205 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 1072459000206 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1072459000207 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1072459000208 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1072459000209 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1072459000210 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1072459000211 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 1072459000212 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 1072459000213 Walker A/P-loop; other site 1072459000214 ATP binding site [chemical binding]; other site 1072459000215 Q-loop/lid; other site 1072459000216 ABC transporter signature motif; other site 1072459000217 Walker B; other site 1072459000218 D-loop; other site 1072459000219 H-loop/switch region; other site 1072459000220 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 1072459000221 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1072459000222 dimer interface [polypeptide binding]; other site 1072459000223 conserved gate region; other site 1072459000224 putative PBP binding loops; other site 1072459000225 ABC-ATPase subunit interface; other site 1072459000226 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1072459000227 dimer interface [polypeptide binding]; other site 1072459000228 conserved gate region; other site 1072459000229 putative PBP binding loops; other site 1072459000230 ABC-ATPase subunit interface; other site 1072459000231 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 1072459000232 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 1072459000233 transcriptional regulator SgrR; Provisional; Region: PRK13626 1072459000234 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1072459000235 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 1072459000236 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1072459000237 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1072459000238 substrate binding site [chemical binding]; other site 1072459000239 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1072459000240 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1072459000241 substrate binding site [chemical binding]; other site 1072459000242 ligand binding site [chemical binding]; other site 1072459000243 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1072459000244 tartrate dehydrogenase; Region: TTC; TIGR02089 1072459000245 2-isopropylmalate synthase; Validated; Region: PRK00915 1072459000246 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1072459000247 active site 1072459000248 catalytic residues [active] 1072459000249 metal binding site [ion binding]; metal-binding site 1072459000250 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1072459000251 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 1072459000252 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1072459000253 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 1072459000254 putative substrate binding pocket [chemical binding]; other site 1072459000255 putative dimerization interface [polypeptide binding]; other site 1072459000256 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 1072459000257 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1072459000258 PYR/PP interface [polypeptide binding]; other site 1072459000259 dimer interface [polypeptide binding]; other site 1072459000260 TPP binding site [chemical binding]; other site 1072459000261 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1072459000262 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1072459000263 TPP-binding site [chemical binding]; other site 1072459000264 dimer interface [polypeptide binding]; other site 1072459000265 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1072459000266 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1072459000267 putative valine binding site [chemical binding]; other site 1072459000268 dimer interface [polypeptide binding]; other site 1072459000269 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1072459000270 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 1072459000271 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1072459000272 DNA binding site [nucleotide binding] 1072459000273 domain linker motif; other site 1072459000274 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 1072459000275 dimerization interface [polypeptide binding]; other site 1072459000276 ligand binding site [chemical binding]; other site 1072459000277 mraZ protein; Region: TIGR00242 1072459000278 MraZ protein; Region: MraZ; pfam02381 1072459000279 MraZ protein; Region: MraZ; pfam02381 1072459000280 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 1072459000281 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1072459000282 cell division protein FtsL; Provisional; Region: PRK10772 1072459000283 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 1072459000284 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1072459000285 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1072459000286 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1072459000287 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1072459000288 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1072459000289 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1072459000290 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 1072459000291 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1072459000292 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1072459000293 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1072459000294 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1072459000295 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1072459000296 Mg++ binding site [ion binding]; other site 1072459000297 putative catalytic motif [active] 1072459000298 putative substrate binding site [chemical binding]; other site 1072459000299 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 1072459000300 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1072459000301 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1072459000302 cell division protein FtsW; Provisional; Region: PRK10774 1072459000303 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1072459000304 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1072459000305 active site 1072459000306 homodimer interface [polypeptide binding]; other site 1072459000307 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1072459000308 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1072459000309 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1072459000310 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1072459000311 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1072459000312 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1072459000313 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1072459000314 cell division protein FtsQ; Provisional; Region: PRK10775 1072459000315 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1072459000316 Cell division protein FtsQ; Region: FtsQ; pfam03799 1072459000317 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 1072459000318 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1072459000319 Cell division protein FtsA; Region: FtsA; pfam14450 1072459000320 cell division protein FtsZ; Validated; Region: PRK09330 1072459000321 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1072459000322 nucleotide binding site [chemical binding]; other site 1072459000323 SulA interaction site; other site 1072459000324 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 1072459000325 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1072459000326 SecA regulator SecM; Provisional; Region: PRK02943 1072459000327 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1072459000328 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1072459000329 SEC-C motif; Region: SEC-C; pfam02810 1072459000330 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1072459000331 active site 1072459000332 8-oxo-dGMP binding site [chemical binding]; other site 1072459000333 nudix motif; other site 1072459000334 metal binding site [ion binding]; metal-binding site 1072459000335 DNA gyrase inhibitor; Reviewed; Region: PRK00418 1072459000336 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 1072459000337 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1072459000338 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1072459000339 CoA-binding site [chemical binding]; other site 1072459000340 ATP-binding [chemical binding]; other site 1072459000341 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 1072459000342 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1072459000343 active site 1072459000344 type IV pilin biogenesis protein; Provisional; Region: PRK10573 1072459000345 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1072459000346 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1072459000347 hypothetical protein; Provisional; Region: PRK10436 1072459000348 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1072459000349 Walker A motif; other site 1072459000350 ATP binding site [chemical binding]; other site 1072459000351 Walker B motif; other site 1072459000352 putative major pilin subunit; Provisional; Region: PRK10574 1072459000353 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1072459000354 Pilin (bacterial filament); Region: Pilin; pfam00114 1072459000355 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 1072459000356 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1072459000357 dimerization interface [polypeptide binding]; other site 1072459000358 active site 1072459000359 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1072459000360 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1072459000361 amidase catalytic site [active] 1072459000362 Zn binding residues [ion binding]; other site 1072459000363 substrate binding site [chemical binding]; other site 1072459000364 regulatory protein AmpE; Provisional; Region: PRK10987 1072459000365 aromatic amino acid transporter; Provisional; Region: PRK10238 1072459000366 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1072459000367 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1072459000368 DNA-binding site [nucleotide binding]; DNA binding site 1072459000369 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1072459000370 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1072459000371 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1072459000372 dimer interface [polypeptide binding]; other site 1072459000373 TPP-binding site [chemical binding]; other site 1072459000374 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 1072459000375 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1072459000376 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1072459000377 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1072459000378 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 1072459000379 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 1072459000380 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 1072459000381 substrate binding site [chemical binding]; other site 1072459000382 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 1072459000383 substrate binding site [chemical binding]; other site 1072459000384 ligand binding site [chemical binding]; other site 1072459000385 hypothetical protein; Provisional; Region: PRK05248 1072459000386 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 1072459000387 spermidine synthase; Provisional; Region: PRK00811 1072459000388 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1072459000389 S-adenosylmethionine binding site [chemical binding]; other site 1072459000390 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 1072459000391 multicopper oxidase; Provisional; Region: PRK10965 1072459000392 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1072459000393 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1072459000394 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1072459000395 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 1072459000396 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 1072459000397 Trp docking motif [polypeptide binding]; other site 1072459000398 putative active site [active] 1072459000399 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1072459000400 active site 1072459000401 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 1072459000402 active site clefts [active] 1072459000403 zinc binding site [ion binding]; other site 1072459000404 dimer interface [polypeptide binding]; other site 1072459000405 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1072459000406 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1072459000407 Walker A/P-loop; other site 1072459000408 ATP binding site [chemical binding]; other site 1072459000409 Q-loop/lid; other site 1072459000410 ABC transporter signature motif; other site 1072459000411 Walker B; other site 1072459000412 D-loop; other site 1072459000413 H-loop/switch region; other site 1072459000414 inner membrane transport permease; Provisional; Region: PRK15066 1072459000415 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1072459000416 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1072459000417 active pocket/dimerization site; other site 1072459000418 active site 1072459000419 phosphorylation site [posttranslational modification] 1072459000420 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 1072459000421 putative active site [active] 1072459000422 putative metal binding site [ion binding]; other site 1072459000423 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1072459000424 tetramerization interface [polypeptide binding]; other site 1072459000425 active site 1072459000426 Uncharacterized conserved protein [Function unknown]; Region: COG5464 1072459000427 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1072459000428 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 1072459000429 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1072459000430 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1072459000431 active site 1072459000432 ATP-binding site [chemical binding]; other site 1072459000433 pantoate-binding site; other site 1072459000434 HXXH motif; other site 1072459000435 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1072459000436 oligomerization interface [polypeptide binding]; other site 1072459000437 active site 1072459000438 metal binding site [ion binding]; metal-binding site 1072459000439 putative transposase OrfB; Reviewed; Region: PHA02517 1072459000440 HTH-like domain; Region: HTH_21; pfam13276 1072459000441 Integrase core domain; Region: rve; pfam00665 1072459000442 Integrase core domain; Region: rve_3; pfam13683 1072459000443 putative fimbrial protein StaF; Provisional; Region: PRK15262 1072459000444 putative fimbrial protein StaE; Provisional; Region: PRK15263 1072459000445 Fimbrial protein; Region: Fimbrial; cl01416 1072459000446 putative fimbrial outer membrane usher protein; Provisional; Region: PRK09828 1072459000447 PapC N-terminal domain; Region: PapC_N; pfam13954 1072459000448 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1072459000449 PapC C-terminal domain; Region: PapC_C; pfam13953 1072459000450 putative chaperone protein EcpD; Provisional; Region: PRK09926 1072459000451 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1072459000452 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1072459000453 Fimbrial protein; Region: Fimbrial; cl01416 1072459000454 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1072459000455 catalytic center binding site [active] 1072459000456 ATP binding site [chemical binding]; other site 1072459000457 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 1072459000458 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1072459000459 active site 1072459000460 NTP binding site [chemical binding]; other site 1072459000461 metal binding triad [ion binding]; metal-binding site 1072459000462 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1072459000463 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 1072459000464 glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838 1072459000465 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 1072459000466 active site 1072459000467 nucleotide binding site [chemical binding]; other site 1072459000468 HIGH motif; other site 1072459000469 KMSKS motif; other site 1072459000470 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 1072459000471 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 1072459000472 2'-5' RNA ligase; Provisional; Region: PRK15124 1072459000473 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1072459000474 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1072459000475 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 1072459000476 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1072459000477 ATP binding site [chemical binding]; other site 1072459000478 putative Mg++ binding site [ion binding]; other site 1072459000479 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1072459000480 nucleotide binding region [chemical binding]; other site 1072459000481 ATP-binding site [chemical binding]; other site 1072459000482 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 1072459000483 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1072459000484 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 1072459000485 Transglycosylase; Region: Transgly; pfam00912 1072459000486 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1072459000487 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1072459000488 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1072459000489 N-terminal plug; other site 1072459000490 ligand-binding site [chemical binding]; other site 1072459000491 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 1072459000492 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1072459000493 Walker A/P-loop; other site 1072459000494 ATP binding site [chemical binding]; other site 1072459000495 Q-loop/lid; other site 1072459000496 ABC transporter signature motif; other site 1072459000497 Walker B; other site 1072459000498 D-loop; other site 1072459000499 H-loop/switch region; other site 1072459000500 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1072459000501 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1072459000502 siderophore binding site; other site 1072459000503 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1072459000504 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1072459000505 ABC-ATPase subunit interface; other site 1072459000506 dimer interface [polypeptide binding]; other site 1072459000507 putative PBP binding regions; other site 1072459000508 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1072459000509 ABC-ATPase subunit interface; other site 1072459000510 dimer interface [polypeptide binding]; other site 1072459000511 putative PBP binding regions; other site 1072459000512 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1072459000513 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1072459000514 inhibitor-cofactor binding pocket; inhibition site 1072459000515 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1072459000516 catalytic residue [active] 1072459000517 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1072459000518 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 1072459000519 Cl- selectivity filter; other site 1072459000520 Cl- binding residues [ion binding]; other site 1072459000521 pore gating glutamate residue; other site 1072459000522 dimer interface [polypeptide binding]; other site 1072459000523 H+/Cl- coupling transport residue; other site 1072459000524 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 1072459000525 hypothetical protein; Provisional; Region: PRK10578 1072459000526 UPF0126 domain; Region: UPF0126; pfam03458 1072459000527 UPF0126 domain; Region: UPF0126; pfam03458 1072459000528 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 1072459000529 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 1072459000530 cobalamin binding residues [chemical binding]; other site 1072459000531 putative BtuC binding residues; other site 1072459000532 dimer interface [polypeptide binding]; other site 1072459000533 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1072459000534 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1072459000535 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 1072459000536 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1072459000537 Zn2+ binding site [ion binding]; other site 1072459000538 Mg2+ binding site [ion binding]; other site 1072459000539 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1072459000540 serine endoprotease; Provisional; Region: PRK10942 1072459000541 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1072459000542 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1072459000543 protein binding site [polypeptide binding]; other site 1072459000544 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1072459000545 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 1072459000546 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1072459000547 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1072459000548 hypothetical protein; Provisional; Region: PRK13677 1072459000549 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 1072459000550 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1072459000551 trimer interface [polypeptide binding]; other site 1072459000552 active site 1072459000553 substrate binding site [chemical binding]; other site 1072459000554 CoA binding site [chemical binding]; other site 1072459000555 PII uridylyl-transferase; Provisional; Region: PRK05007 1072459000556 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1072459000557 metal binding triad; other site 1072459000558 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1072459000559 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1072459000560 Zn2+ binding site [ion binding]; other site 1072459000561 Mg2+ binding site [ion binding]; other site 1072459000562 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 1072459000563 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 1072459000564 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1072459000565 active site 1072459000566 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1072459000567 rRNA interaction site [nucleotide binding]; other site 1072459000568 S8 interaction site; other site 1072459000569 putative laminin-1 binding site; other site 1072459000570 elongation factor Ts; Provisional; Region: tsf; PRK09377 1072459000571 UBA/TS-N domain; Region: UBA; pfam00627 1072459000572 Elongation factor TS; Region: EF_TS; pfam00889 1072459000573 Elongation factor TS; Region: EF_TS; pfam00889 1072459000574 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1072459000575 putative nucleotide binding site [chemical binding]; other site 1072459000576 uridine monophosphate binding site [chemical binding]; other site 1072459000577 homohexameric interface [polypeptide binding]; other site 1072459000578 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1072459000579 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1072459000580 hinge region; other site 1072459000581 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1072459000582 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1072459000583 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1072459000584 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1072459000585 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1072459000586 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1072459000587 catalytic residue [active] 1072459000588 putative FPP diphosphate binding site; other site 1072459000589 putative FPP binding hydrophobic cleft; other site 1072459000590 dimer interface [polypeptide binding]; other site 1072459000591 putative IPP diphosphate binding site; other site 1072459000592 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 1072459000593 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1072459000594 zinc metallopeptidase RseP; Provisional; Region: PRK10779 1072459000595 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1072459000596 active site 1072459000597 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1072459000598 protein binding site [polypeptide binding]; other site 1072459000599 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1072459000600 putative substrate binding region [chemical binding]; other site 1072459000601 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 1072459000602 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1072459000603 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1072459000604 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1072459000605 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1072459000606 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1072459000607 Surface antigen; Region: Bac_surface_Ag; pfam01103 1072459000608 periplasmic chaperone; Provisional; Region: PRK10780 1072459000609 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 1072459000610 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1072459000611 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1072459000612 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1072459000613 trimer interface [polypeptide binding]; other site 1072459000614 active site 1072459000615 UDP-GlcNAc binding site [chemical binding]; other site 1072459000616 lipid binding site [chemical binding]; lipid-binding site 1072459000617 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1072459000618 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1072459000619 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1072459000620 active site 1072459000621 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1072459000622 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1072459000623 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1072459000624 RNA/DNA hybrid binding site [nucleotide binding]; other site 1072459000625 active site 1072459000626 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1072459000627 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 1072459000628 putative active site [active] 1072459000629 putative PHP Thumb interface [polypeptide binding]; other site 1072459000630 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1072459000631 generic binding surface II; other site 1072459000632 generic binding surface I; other site 1072459000633 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1072459000634 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1072459000635 lysine decarboxylase LdcC; Provisional; Region: PRK15399 1072459000636 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1072459000637 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1072459000638 homodimer interface [polypeptide binding]; other site 1072459000639 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1072459000640 catalytic residue [active] 1072459000641 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1072459000642 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 1072459000643 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1072459000644 putative metal binding site [ion binding]; other site 1072459000645 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 1072459000646 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1072459000647 Ligand Binding Site [chemical binding]; other site 1072459000648 TilS substrate binding domain; Region: TilS; pfam09179 1072459000649 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 1072459000650 Rho-binding antiterminator; Provisional; Region: PRK11625 1072459000651 hypothetical protein; Provisional; Region: PRK04964 1072459000652 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 1072459000653 hypothetical protein; Provisional; Region: PRK09256 1072459000654 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1072459000655 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 1072459000656 NlpE N-terminal domain; Region: NlpE; pfam04170 1072459000657 hypothetical protein; Provisional; Region: PRK11479 1072459000658 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 1072459000659 NlpC/P60 family; Region: NLPC_P60; cl17555 1072459000660 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1072459000661 Transposase; Region: HTH_Tnp_1; cl17663 1072459000662 HTH-like domain; Region: HTH_21; pfam13276 1072459000663 Integrase core domain; Region: rve; pfam00665 1072459000664 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1072459000665 Integrase core domain; Region: rve_3; pfam13683 1072459000666 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1072459000667 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1072459000668 dimer interface [polypeptide binding]; other site 1072459000669 motif 1; other site 1072459000670 active site 1072459000671 motif 2; other site 1072459000672 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1072459000673 putative deacylase active site [active] 1072459000674 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1072459000675 active site 1072459000676 motif 3; other site 1072459000677 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1072459000678 anticodon binding site; other site 1072459000679 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 1072459000680 homodimer interaction site [polypeptide binding]; other site 1072459000681 cofactor binding site; other site 1072459000682 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 1072459000683 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 1072459000684 lipoprotein, YaeC family; Region: TIGR00363 1072459000685 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1072459000686 dimer interface [polypeptide binding]; other site 1072459000687 conserved gate region; other site 1072459000688 ABC-ATPase subunit interface; other site 1072459000689 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1072459000690 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1072459000691 Walker A/P-loop; other site 1072459000692 ATP binding site [chemical binding]; other site 1072459000693 Q-loop/lid; other site 1072459000694 ABC transporter signature motif; other site 1072459000695 Walker B; other site 1072459000696 D-loop; other site 1072459000697 H-loop/switch region; other site 1072459000698 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1072459000699 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 1072459000700 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1072459000701 active site 1072459000702 motif I; other site 1072459000703 motif II; other site 1072459000704 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1072459000705 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1072459000706 active site 1072459000707 catalytic tetrad [active] 1072459000708 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1072459000709 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1072459000710 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 1072459000711 putative effector binding pocket; other site 1072459000712 dimerization interface [polypeptide binding]; other site 1072459000713 hypothetical protein; Provisional; Region: PRK05421 1072459000714 putative catalytic site [active] 1072459000715 putative metal binding site [ion binding]; other site 1072459000716 putative phosphate binding site [ion binding]; other site 1072459000717 putative catalytic site [active] 1072459000718 putative phosphate binding site [ion binding]; other site 1072459000719 putative metal binding site [ion binding]; other site 1072459000720 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1072459000721 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1072459000722 S-adenosylmethionine binding site [chemical binding]; other site 1072459000723 Flavivirus glycoprotein, central and dimerisation domains; Region: Flavi_glycoprot; pfam00869 1072459000724 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 1072459000725 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1072459000726 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1072459000727 catalytic residue [active] 1072459000728 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1072459000729 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1072459000730 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 1072459000731 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1072459000732 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1072459000733 RNA/DNA hybrid binding site [nucleotide binding]; other site 1072459000734 active site 1072459000735 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 1072459000736 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 1072459000737 active site 1072459000738 catalytic site [active] 1072459000739 substrate binding site [chemical binding]; other site 1072459000740 C-N hydrolase family amidase; Provisional; Region: PRK10438 1072459000741 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 1072459000742 putative active site [active] 1072459000743 catalytic triad [active] 1072459000744 dimer interface [polypeptide binding]; other site 1072459000745 multimer interface [polypeptide binding]; other site 1072459000746 C-lysozyme inhibitor; Provisional; Region: PRK09993 1072459000747 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 1072459000748 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1072459000749 active site 1072459000750 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 1072459000751 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1072459000752 dimer interface [polypeptide binding]; other site 1072459000753 active site 1072459000754 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 1072459000755 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1072459000756 putative active site [active] 1072459000757 putative dimer interface [polypeptide binding]; other site 1072459000758 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 1072459000759 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1072459000760 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041 1072459000761 RelB antitoxin; Region: RelB; pfam04221 1072459000762 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1072459000763 NlpC/P60 family; Region: NLPC_P60; pfam00877 1072459000764 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 1072459000765 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298 1072459000766 FHIPEP family; Region: FHIPEP; pfam00771 1072459000767 hypothetical protein; Validated; Region: PRK06778 1072459000768 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1072459000769 ligand binding site [chemical binding]; other site 1072459000770 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1072459000771 active site 1072459000772 DNA polymerase IV; Validated; Region: PRK02406 1072459000773 DNA binding site [nucleotide binding] 1072459000774 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1072459000775 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1072459000776 Coenzyme A binding pocket [chemical binding]; other site 1072459000777 hypothetical protein; Reviewed; Region: PRK09588 1072459000778 release factor H-coupled RctB family protein; Region: release_rtcB; TIGR03073 1072459000779 peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179 1072459000780 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1072459000781 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 1072459000782 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 1072459000783 metal binding site [ion binding]; metal-binding site 1072459000784 dimer interface [polypeptide binding]; other site 1072459000785 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1072459000786 active site 1072459000787 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 1072459000788 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 1072459000789 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1072459000790 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1072459000791 trimer interface [polypeptide binding]; other site 1072459000792 eyelet of channel; other site 1072459000793 gamma-glutamyl kinase; Provisional; Region: PRK05429 1072459000794 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1072459000795 nucleotide binding site [chemical binding]; other site 1072459000796 homotetrameric interface [polypeptide binding]; other site 1072459000797 putative phosphate binding site [ion binding]; other site 1072459000798 putative allosteric binding site; other site 1072459000799 PUA domain; Region: PUA; pfam01472 1072459000800 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1072459000801 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1072459000802 putative catalytic cysteine [active] 1072459000803 putative transposase OrfB; Reviewed; Region: PHA02517 1072459000804 Integrase core domain; Region: rve; pfam00665 1072459000805 Integrase core domain; Region: rve_3; pfam13683 1072459000806 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1072459000807 Transposase; Region: HTH_Tnp_1; pfam01527 1072459000808 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 1072459000809 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1072459000810 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1072459000811 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 1072459000812 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1072459000813 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1072459000814 DNA binding residues [nucleotide binding] 1072459000815 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 1072459000816 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1072459000817 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1072459000818 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 1072459000819 putative active site [active] 1072459000820 putative FMN binding site [chemical binding]; other site 1072459000821 putative substrate binding site [chemical binding]; other site 1072459000822 putative catalytic residue [active] 1072459000823 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1072459000824 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1072459000825 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1072459000826 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1072459000827 putative effector binding pocket; other site 1072459000828 putative dimerization interface [polypeptide binding]; other site 1072459000829 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1072459000830 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1072459000831 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1072459000832 putative effector binding pocket; other site 1072459000833 putative dimerization interface [polypeptide binding]; other site 1072459000834 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1072459000835 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1072459000836 active site 1072459000837 catalytic tetrad [active] 1072459000838 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1072459000839 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1072459000840 active site 1072459000841 catalytic tetrad [active] 1072459000842 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 1072459000843 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1072459000844 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1072459000845 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1072459000846 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1072459000847 active site 1072459000848 catalytic tetrad [active] 1072459000849 Predicted membrane protein [Function unknown]; Region: COG3059 1072459000850 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1072459000851 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010 1072459000852 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1072459000853 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1072459000854 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1072459000855 Cupin; Region: Cupin_6; pfam12852 1072459000856 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1072459000857 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1072459000858 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1072459000859 Cysteine-rich domain; Region: CCG; pfam02754 1072459000860 Cysteine-rich domain; Region: CCG; pfam02754 1072459000861 iron-sulfur cluster-binding protein; Region: TIGR00273 1072459000862 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1072459000863 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1072459000864 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 1072459000865 Uncharacterized conserved protein [Function unknown]; Region: COG1556 1072459000866 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1072459000867 choline dehydrogenase; Validated; Region: PRK02106 1072459000868 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1072459000869 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 1072459000870 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 1072459000871 tetrameric interface [polypeptide binding]; other site 1072459000872 NAD binding site [chemical binding]; other site 1072459000873 catalytic residues [active] 1072459000874 transcriptional regulator BetI; Validated; Region: PRK00767 1072459000875 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1072459000876 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1072459000877 choline transport protein BetT; Provisional; Region: PRK09928 1072459000878 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1072459000879 DNA binding residues [nucleotide binding] 1072459000880 dimerization interface [polypeptide binding]; other site 1072459000881 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1072459000882 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 1072459000883 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1072459000884 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1072459000885 dimerization interface [polypeptide binding]; other site 1072459000886 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 1072459000887 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1072459000888 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1072459000889 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1072459000890 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 1072459000891 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 1072459000892 CoA binding domain; Region: CoA_binding; pfam02629 1072459000893 CoA-ligase; Region: Ligase_CoA; pfam00549 1072459000894 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 1072459000895 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 1072459000896 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1072459000897 putative substrate binding site [chemical binding]; other site 1072459000898 nucleotide binding site [chemical binding]; other site 1072459000899 nucleotide binding site [chemical binding]; other site 1072459000900 homodimer interface [polypeptide binding]; other site 1072459000901 putative deaminase; Validated; Region: PRK06846 1072459000902 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1072459000903 active site 1072459000904 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 1072459000905 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 1072459000906 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1072459000907 ligand binding site [chemical binding]; other site 1072459000908 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1072459000909 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1072459000910 Walker A/P-loop; other site 1072459000911 ATP binding site [chemical binding]; other site 1072459000912 Q-loop/lid; other site 1072459000913 ABC transporter signature motif; other site 1072459000914 Walker B; other site 1072459000915 D-loop; other site 1072459000916 H-loop/switch region; other site 1072459000917 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1072459000918 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1072459000919 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1072459000920 TM-ABC transporter signature motif; other site 1072459000921 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1072459000922 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1072459000923 TM-ABC transporter signature motif; other site 1072459000924 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1072459000925 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1072459000926 putative NAD(P) binding site [chemical binding]; other site 1072459000927 putative substrate binding site [chemical binding]; other site 1072459000928 catalytic Zn binding site [ion binding]; other site 1072459000929 structural Zn binding site [ion binding]; other site 1072459000930 dimer interface [polypeptide binding]; other site 1072459000931 The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949 1072459000932 hypothetical protein; Provisional; Region: PRK09929 1072459000933 propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424 1072459000934 Propionate catabolism activator; Region: PrpR_N; pfam06506 1072459000935 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1072459000936 Walker A motif; other site 1072459000937 ATP binding site [chemical binding]; other site 1072459000938 Walker B motif; other site 1072459000939 arginine finger; other site 1072459000940 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1072459000941 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1072459000942 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1072459000943 tetramer interface [polypeptide binding]; other site 1072459000944 active site 1072459000945 Mg2+/Mn2+ binding site [ion binding]; other site 1072459000946 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1072459000947 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 1072459000948 dimer interface [polypeptide binding]; other site 1072459000949 active site 1072459000950 citrylCoA binding site [chemical binding]; other site 1072459000951 oxalacetate/citrate binding site [chemical binding]; other site 1072459000952 coenzyme A binding site [chemical binding]; other site 1072459000953 catalytic triad [active] 1072459000954 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 1072459000955 2-methylcitrate dehydratase; Region: prpD; TIGR02330 1072459000956 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 1072459000957 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 1072459000958 acyl-activating enzyme (AAE) consensus motif; other site 1072459000959 putative AMP binding site [chemical binding]; other site 1072459000960 putative active site [active] 1072459000961 putative CoA binding site [chemical binding]; other site 1072459000962 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 1072459000963 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1072459000964 Na binding site [ion binding]; other site 1072459000965 putative substrate binding site [chemical binding]; other site 1072459000966 cytosine deaminase; Provisional; Region: PRK09230 1072459000967 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1072459000968 active site 1072459000969 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 1072459000970 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1072459000971 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425 1072459000972 dimerization interface [polypeptide binding]; other site 1072459000973 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 1072459000974 active site clefts [active] 1072459000975 zinc binding site [ion binding]; other site 1072459000976 dimer interface [polypeptide binding]; other site 1072459000977 Cyanate lyase [Inorganic ion transport and metabolism]; Region: CynS; COG1513 1072459000978 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 1072459000979 oligomer interface [polypeptide binding]; other site 1072459000980 active site 1072459000981 putative cyanate transporter; Provisional; Region: cynX; PRK09705 1072459000982 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459000983 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 1072459000984 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1072459000985 active site 1072459000986 substrate binding site [chemical binding]; other site 1072459000987 trimer interface [polypeptide binding]; other site 1072459000988 CoA binding site [chemical binding]; other site 1072459000989 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 1072459000990 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459000991 putative substrate translocation pore; other site 1072459000992 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 1072459000993 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1072459000994 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1072459000995 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1072459000996 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 1072459000997 lac repressor; Reviewed; Region: lacI; PRK09526 1072459000998 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1072459000999 DNA binding site [nucleotide binding] 1072459001000 domain linker motif; other site 1072459001001 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 1072459001002 ligand binding site [chemical binding]; other site 1072459001003 dimerization interface (open form) [polypeptide binding]; other site 1072459001004 dimerization interface (closed form) [polypeptide binding]; other site 1072459001005 DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834 1072459001006 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1072459001007 Bacterial transcriptional regulator; Region: IclR; pfam01614 1072459001008 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 1072459001009 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1072459001010 Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB), which catalyzes the oxidization and subsequent ring-opening of 2,3-dihydroxyphenylpropionate; Region: MhpB_like; cd07365 1072459001011 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1072459001012 putative active site [active] 1072459001013 Fe(II) binding site [ion binding]; other site 1072459001014 putative dimer interface [polypeptide binding]; other site 1072459001015 putative tetramer interface [polypeptide binding]; other site 1072459001016 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 1072459001017 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1072459001018 nucleophilic elbow; other site 1072459001019 catalytic triad; other site 1072459001020 2-keto-4-pentenoate hydratase; Provisional; Region: mhpD; PRK11342 1072459001021 acetaldehyde dehydrogenase; Validated; Region: PRK08300 1072459001022 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1072459001023 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 1072459001024 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1072459001025 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 1072459001026 active site 1072459001027 catalytic residues [active] 1072459001028 metal binding site [ion binding]; metal-binding site 1072459001029 DmpG-like communication domain; Region: DmpG_comm; pfam07836 1072459001030 D-galactonate transporter; Region: 2A0114; TIGR00893 1072459001031 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459001032 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459001033 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 1072459001034 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 1072459001035 S-formylglutathione hydrolase; Region: PLN02442 1072459001036 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 1072459001037 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 1072459001038 substrate binding site [chemical binding]; other site 1072459001039 catalytic Zn binding site [ion binding]; other site 1072459001040 NAD binding site [chemical binding]; other site 1072459001041 structural Zn binding site [ion binding]; other site 1072459001042 dimer interface [polypeptide binding]; other site 1072459001043 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 1072459001044 putative metal binding site [ion binding]; other site 1072459001045 putative homodimer interface [polypeptide binding]; other site 1072459001046 putative homotetramer interface [polypeptide binding]; other site 1072459001047 putative homodimer-homodimer interface [polypeptide binding]; other site 1072459001048 putative allosteric switch controlling residues; other site 1072459001049 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1072459001050 putative trimer interface [polypeptide binding]; other site 1072459001051 putative CoA binding site [chemical binding]; other site 1072459001052 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1072459001053 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1072459001054 DXD motif; other site 1072459001055 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 1072459001056 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 1072459001057 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1072459001058 substrate binding pocket [chemical binding]; other site 1072459001059 membrane-bound complex binding site; other site 1072459001060 hinge residues; other site 1072459001061 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 1072459001062 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1072459001063 Walker A/P-loop; other site 1072459001064 ATP binding site [chemical binding]; other site 1072459001065 Q-loop/lid; other site 1072459001066 ABC transporter signature motif; other site 1072459001067 Walker B; other site 1072459001068 D-loop; other site 1072459001069 H-loop/switch region; other site 1072459001070 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1072459001071 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1072459001072 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 1072459001073 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1072459001074 dimer interface [polypeptide binding]; other site 1072459001075 active site 1072459001076 Schiff base residues; other site 1072459001077 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 1072459001078 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1072459001079 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1072459001080 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 1072459001081 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 1072459001082 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1072459001083 microcin B17 transporter; Reviewed; Region: PRK11098 1072459001084 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 1072459001085 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 1072459001086 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 1072459001087 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1072459001088 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1072459001089 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1072459001090 anti-RssB factor; Provisional; Region: PRK10244 1072459001091 alkaline phosphatase; Provisional; Region: PRK10518 1072459001092 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1072459001093 dimer interface [polypeptide binding]; other site 1072459001094 active site 1072459001095 hypothetical protein; Provisional; Region: PRK11505 1072459001096 psiF repeat; Region: PsiF_repeat; pfam07769 1072459001097 psiF repeat; Region: PsiF_repeat; pfam07769 1072459001098 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 1072459001099 MASE2 domain; Region: MASE2; pfam05230 1072459001100 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1072459001101 metal binding site [ion binding]; metal-binding site 1072459001102 active site 1072459001103 I-site; other site 1072459001104 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1072459001105 pyrroline-5-carboxylate reductase; Region: PLN02688 1072459001106 hypothetical protein; Validated; Region: PRK00124 1072459001107 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 1072459001108 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1072459001109 ADP binding site [chemical binding]; other site 1072459001110 magnesium binding site [ion binding]; other site 1072459001111 putative shikimate binding site; other site 1072459001112 hypothetical protein; Provisional; Region: PRK10380 1072459001113 hypothetical protein; Provisional; Region: PRK10481 1072459001114 hypothetical protein; Provisional; Region: PRK10579 1072459001115 Protein of unknown function (DUF2773); Region: DUF2773; pfam10971 1072459001116 DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974 1072459001117 fructokinase; Reviewed; Region: PRK09557 1072459001118 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1072459001119 nucleotide binding site [chemical binding]; other site 1072459001120 MFS transport protein AraJ; Provisional; Region: PRK10091 1072459001121 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459001122 putative substrate translocation pore; other site 1072459001123 exonuclease subunit SbcC; Provisional; Region: PRK10246 1072459001124 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1072459001125 Walker A/P-loop; other site 1072459001126 ATP binding site [chemical binding]; other site 1072459001127 Q-loop/lid; other site 1072459001128 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1072459001129 ABC transporter signature motif; other site 1072459001130 Walker B; other site 1072459001131 D-loop; other site 1072459001132 H-loop/switch region; other site 1072459001133 exonuclease subunit SbcD; Provisional; Region: PRK10966 1072459001134 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1072459001135 active site 1072459001136 metal binding site [ion binding]; metal-binding site 1072459001137 DNA binding site [nucleotide binding] 1072459001138 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1072459001139 transcriptional regulator PhoB; Provisional; Region: PRK10161 1072459001140 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1072459001141 active site 1072459001142 phosphorylation site [posttranslational modification] 1072459001143 intermolecular recognition site; other site 1072459001144 dimerization interface [polypeptide binding]; other site 1072459001145 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1072459001146 DNA binding site [nucleotide binding] 1072459001147 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 1072459001148 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 1072459001149 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1072459001150 putative active site [active] 1072459001151 heme pocket [chemical binding]; other site 1072459001152 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1072459001153 dimer interface [polypeptide binding]; other site 1072459001154 phosphorylation site [posttranslational modification] 1072459001155 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1072459001156 ATP binding site [chemical binding]; other site 1072459001157 Mg2+ binding site [ion binding]; other site 1072459001158 G-X-G motif; other site 1072459001159 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 1072459001160 putative proline-specific permease; Provisional; Region: proY; PRK10580 1072459001161 Spore germination protein; Region: Spore_permease; cl17796 1072459001162 maltodextrin glucosidase; Provisional; Region: PRK10785 1072459001163 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 1072459001164 homodimer interface [polypeptide binding]; other site 1072459001165 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1072459001166 active site 1072459001167 homodimer interface [polypeptide binding]; other site 1072459001168 catalytic site [active] 1072459001169 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 1072459001170 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1072459001171 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1072459001172 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1072459001173 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 1072459001174 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1072459001175 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 1072459001176 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1072459001177 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1072459001178 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1072459001179 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1072459001180 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1072459001181 Protein export membrane protein; Region: SecD_SecF; pfam02355 1072459001182 Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693 1072459001183 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1072459001184 active site 1072459001185 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 1072459001186 Protein of unknown function (DUF3251); Region: DUF3251; cl08186 1072459001187 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1072459001188 Probable transposase; Region: OrfB_IS605; pfam01385 1072459001189 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1072459001190 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 1072459001191 Protein of unknown function (DUF3251); Region: DUF3251; cl08186 1072459001192 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1072459001193 ATP cone domain; Region: ATP-cone; pfam03477 1072459001194 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 1072459001195 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1072459001196 catalytic motif [active] 1072459001197 Zn binding site [ion binding]; other site 1072459001198 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 1072459001199 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1072459001200 homopentamer interface [polypeptide binding]; other site 1072459001201 active site 1072459001202 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1072459001203 putative RNA binding site [nucleotide binding]; other site 1072459001204 thiamine monophosphate kinase; Provisional; Region: PRK05731 1072459001205 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1072459001206 ATP binding site [chemical binding]; other site 1072459001207 dimerization interface [polypeptide binding]; other site 1072459001208 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1072459001209 tetramer interfaces [polypeptide binding]; other site 1072459001210 binuclear metal-binding site [ion binding]; other site 1072459001211 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1072459001212 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1072459001213 active site 1072459001214 catalytic tetrad [active] 1072459001215 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 1072459001216 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1072459001217 TPP-binding site; other site 1072459001218 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1072459001219 PYR/PP interface [polypeptide binding]; other site 1072459001220 dimer interface [polypeptide binding]; other site 1072459001221 TPP binding site [chemical binding]; other site 1072459001222 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1072459001223 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1072459001224 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1072459001225 substrate binding pocket [chemical binding]; other site 1072459001226 chain length determination region; other site 1072459001227 substrate-Mg2+ binding site; other site 1072459001228 catalytic residues [active] 1072459001229 aspartate-rich region 1; other site 1072459001230 active site lid residues [active] 1072459001231 aspartate-rich region 2; other site 1072459001232 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1072459001233 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 1072459001234 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1072459001235 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1072459001236 Ligand Binding Site [chemical binding]; other site 1072459001237 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1072459001238 active site residue [active] 1072459001239 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 1072459001240 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 1072459001241 conserved cys residue [active] 1072459001242 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1072459001243 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1072459001244 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1072459001245 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1072459001246 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1072459001247 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459001248 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1072459001249 putative substrate translocation pore; other site 1072459001250 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1072459001251 Sel1 repeat; Region: Sel1; pfam08238 1072459001252 Sel1-like repeats; Region: SEL1; smart00671 1072459001253 Sel1-like repeats; Region: SEL1; smart00671 1072459001254 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1072459001255 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1072459001256 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 1072459001257 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 1072459001258 UbiA prenyltransferase family; Region: UbiA; pfam01040 1072459001259 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 1072459001260 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1072459001261 Subunit I/III interface [polypeptide binding]; other site 1072459001262 Subunit III/IV interface [polypeptide binding]; other site 1072459001263 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1072459001264 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1072459001265 D-pathway; other site 1072459001266 Putative ubiquinol binding site [chemical binding]; other site 1072459001267 Low-spin heme (heme b) binding site [chemical binding]; other site 1072459001268 Putative water exit pathway; other site 1072459001269 Binuclear center (heme o3/CuB) [ion binding]; other site 1072459001270 K-pathway; other site 1072459001271 Putative proton exit pathway; other site 1072459001272 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 1072459001273 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1072459001274 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1072459001275 muropeptide transporter; Reviewed; Region: ampG; PRK11902 1072459001276 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459001277 putative substrate translocation pore; other site 1072459001278 hypothetical protein; Provisional; Region: PRK11627 1072459001279 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 1072459001280 transcriptional regulator BolA; Provisional; Region: PRK11628 1072459001281 trigger factor; Provisional; Region: tig; PRK01490 1072459001282 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1072459001283 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1072459001284 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1072459001285 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1072459001286 oligomer interface [polypeptide binding]; other site 1072459001287 active site residues [active] 1072459001288 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1072459001289 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1072459001290 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1072459001291 Walker A motif; other site 1072459001292 ATP binding site [chemical binding]; other site 1072459001293 Walker B motif; other site 1072459001294 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1072459001295 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 1072459001296 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1072459001297 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1072459001298 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1072459001299 Walker A motif; other site 1072459001300 ATP binding site [chemical binding]; other site 1072459001301 Walker B motif; other site 1072459001302 arginine finger; other site 1072459001303 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1072459001304 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1072459001305 IHF dimer interface [polypeptide binding]; other site 1072459001306 IHF - DNA interface [nucleotide binding]; other site 1072459001307 periplasmic folding chaperone; Provisional; Region: PRK10788 1072459001308 SurA N-terminal domain; Region: SurA_N_3; cl07813 1072459001309 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1072459001310 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 1072459001311 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1072459001312 active site 1072459001313 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1072459001314 Ligand Binding Site [chemical binding]; other site 1072459001315 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 1072459001316 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1072459001317 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1072459001318 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 1072459001319 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1072459001320 active site 1072459001321 motif I; other site 1072459001322 motif II; other site 1072459001323 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1072459001324 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1072459001325 putative DNA binding site [nucleotide binding]; other site 1072459001326 putative Zn2+ binding site [ion binding]; other site 1072459001327 AsnC family; Region: AsnC_trans_reg; pfam01037 1072459001328 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1072459001329 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 1072459001330 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1072459001331 Walker A/P-loop; other site 1072459001332 ATP binding site [chemical binding]; other site 1072459001333 Q-loop/lid; other site 1072459001334 ABC transporter signature motif; other site 1072459001335 Walker B; other site 1072459001336 D-loop; other site 1072459001337 H-loop/switch region; other site 1072459001338 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 1072459001339 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1072459001340 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1072459001341 Walker A/P-loop; other site 1072459001342 ATP binding site [chemical binding]; other site 1072459001343 Q-loop/lid; other site 1072459001344 ABC transporter signature motif; other site 1072459001345 Walker B; other site 1072459001346 D-loop; other site 1072459001347 H-loop/switch region; other site 1072459001348 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 1072459001349 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1072459001350 ammonium transporter; Provisional; Region: PRK10666 1072459001351 acyl-CoA thioesterase II; Provisional; Region: PRK10526 1072459001352 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1072459001353 active site 1072459001354 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1072459001355 catalytic triad [active] 1072459001356 dimer interface [polypeptide binding]; other site 1072459001357 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 1072459001358 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1072459001359 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1072459001360 DNA binding site [nucleotide binding] 1072459001361 active site 1072459001362 Uncharacterized conserved protein [Function unknown]; Region: COG5507 1072459001363 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 1072459001364 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1072459001365 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1072459001366 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 1072459001367 maltose O-acetyltransferase; Provisional; Region: PRK10092 1072459001368 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1072459001369 active site 1072459001370 substrate binding site [chemical binding]; other site 1072459001371 trimer interface [polypeptide binding]; other site 1072459001372 CoA binding site [chemical binding]; other site 1072459001373 gene expression modulator; Provisional; Region: PRK10945 1072459001374 Biofilm formation regulator YbaJ; Region: YbaJ; pfam10757 1072459001375 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 1072459001376 Protein export membrane protein; Region: SecD_SecF; cl14618 1072459001377 Protein export membrane protein; Region: SecD_SecF; cl14618 1072459001378 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 1072459001379 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1072459001380 HlyD family secretion protein; Region: HlyD_3; pfam13437 1072459001381 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 1072459001382 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1072459001383 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 1072459001384 hypothetical protein; Provisional; Region: PRK11281 1072459001385 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 1072459001386 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 1072459001387 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1072459001388 hypothetical protein; Provisional; Region: PRK11038 1072459001389 primosomal replication protein N''; Provisional; Region: PRK10093 1072459001390 hypothetical protein; Provisional; Region: PRK10527 1072459001391 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1072459001392 active site 1072459001393 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 1072459001394 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1072459001395 Walker A motif; other site 1072459001396 ATP binding site [chemical binding]; other site 1072459001397 Walker B motif; other site 1072459001398 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1072459001399 arginine finger; other site 1072459001400 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1072459001401 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 1072459001402 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 1072459001403 hypothetical protein; Validated; Region: PRK00153 1072459001404 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecR; COG0353 1072459001405 RecR protein; Region: RecR; pfam02132 1072459001406 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1072459001407 putative active site [active] 1072459001408 putative metal-binding site [ion binding]; other site 1072459001409 tetramer interface [polypeptide binding]; other site 1072459001410 heat shock protein 90; Provisional; Region: PRK05218 1072459001411 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1072459001412 ATP binding site [chemical binding]; other site 1072459001413 Mg2+ binding site [ion binding]; other site 1072459001414 G-X-G motif; other site 1072459001415 adenylate kinase; Reviewed; Region: adk; PRK00279 1072459001416 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1072459001417 AMP-binding site [chemical binding]; other site 1072459001418 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1072459001419 ferrochelatase; Region: hemH; TIGR00109 1072459001420 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1072459001421 C-terminal domain interface [polypeptide binding]; other site 1072459001422 active site 1072459001423 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1072459001424 active site 1072459001425 N-terminal domain interface [polypeptide binding]; other site 1072459001426 acetyl esterase; Provisional; Region: PRK10162 1072459001427 inosine/guanosine kinase; Provisional; Region: PRK15074 1072459001428 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1072459001429 putative cation:proton antiport protein; Provisional; Region: PRK10669 1072459001430 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 1072459001431 TrkA-N domain; Region: TrkA_N; pfam02254 1072459001432 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459001433 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1072459001434 putative substrate translocation pore; other site 1072459001435 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 1072459001436 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 1072459001437 active site 1072459001438 metal binding site [ion binding]; metal-binding site 1072459001439 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1072459001440 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1072459001441 putative deacylase active site [active] 1072459001442 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 1072459001443 copper exporting ATPase; Provisional; Region: copA; PRK10671 1072459001444 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1072459001445 metal-binding site [ion binding] 1072459001446 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1072459001447 metal-binding site [ion binding] 1072459001448 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1072459001449 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1072459001450 motif II; other site 1072459001451 glutaminase; Reviewed; Region: PRK12356 1072459001452 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1072459001453 amino acid transporter; Region: 2A0306; TIGR00909 1072459001454 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1072459001455 potential frameshift: common BLAST hit: gi|218703771|ref|YP_002411290.1| adhesin for cattle intestine colonization 1072459001456 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1072459001457 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1072459001458 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1072459001459 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1072459001460 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1072459001461 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1072459001462 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1072459001463 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1072459001464 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1072459001465 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1072459001466 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1072459001467 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1072459001468 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1072459001469 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1072459001470 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1072459001471 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1072459001472 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1072459001473 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1072459001474 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1072459001475 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1072459001476 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1072459001477 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1072459001478 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1072459001479 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1072459001480 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1072459001481 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1072459001482 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1072459001483 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1072459001484 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1072459001485 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1072459001486 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1072459001487 Family description; Region: VCBS; pfam13517 1072459001488 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 1072459001489 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 1072459001490 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1072459001491 putative active site [active] 1072459001492 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1072459001493 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 1072459001494 Walker A/P-loop; other site 1072459001495 ATP binding site [chemical binding]; other site 1072459001496 Q-loop/lid; other site 1072459001497 ABC transporter signature motif; other site 1072459001498 Walker B; other site 1072459001499 D-loop; other site 1072459001500 H-loop/switch region; other site 1072459001501 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1072459001502 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 1072459001503 HlyD family secretion protein; Region: HlyD_3; pfam13437 1072459001504 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 1072459001505 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 1072459001506 DNA binding residues [nucleotide binding] 1072459001507 dimer interface [polypeptide binding]; other site 1072459001508 copper binding site [ion binding]; other site 1072459001509 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 1072459001510 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1072459001511 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1072459001512 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 1072459001513 YadA-like C-terminal region; Region: YadA; pfam03895 1072459001514 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1072459001515 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1072459001516 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1072459001517 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 1072459001518 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1072459001519 Walker A/P-loop; other site 1072459001520 ATP binding site [chemical binding]; other site 1072459001521 Q-loop/lid; other site 1072459001522 ABC transporter signature motif; other site 1072459001523 Walker B; other site 1072459001524 D-loop; other site 1072459001525 H-loop/switch region; other site 1072459001526 Uncharacterized protein family (UPF0014); Region: UPF0014; pfam03649 1072459001527 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1072459001528 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1072459001529 oxidoreductase; Provisional; Region: PRK08017 1072459001530 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1072459001531 NADP binding site [chemical binding]; other site 1072459001532 active site 1072459001533 steroid binding site; other site 1072459001534 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 1072459001535 active site 1072459001536 oxyanion hole [active] 1072459001537 switch loop; other site 1072459001538 catalytic triad [active] 1072459001539 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 1072459001540 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1072459001541 Walker A/P-loop; other site 1072459001542 ATP binding site [chemical binding]; other site 1072459001543 Q-loop/lid; other site 1072459001544 ABC transporter signature motif; other site 1072459001545 Walker B; other site 1072459001546 D-loop; other site 1072459001547 H-loop/switch region; other site 1072459001548 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 1072459001549 FtsX-like permease family; Region: FtsX; pfam02687 1072459001550 FtsX-like permease family; Region: FtsX; pfam02687 1072459001551 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 1072459001552 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 1072459001553 active site residue [active] 1072459001554 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 1072459001555 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1072459001556 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1072459001557 dimerization interface [polypeptide binding]; other site 1072459001558 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 1072459001559 ureidoglycolate hydrolase; Provisional; Region: PRK03606 1072459001560 DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163 1072459001561 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1072459001562 Bacterial transcriptional regulator; Region: IclR; pfam01614 1072459001563 glyoxylate carboligase; Provisional; Region: PRK11269 1072459001564 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1072459001565 PYR/PP interface [polypeptide binding]; other site 1072459001566 dimer interface [polypeptide binding]; other site 1072459001567 TPP binding site [chemical binding]; other site 1072459001568 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1072459001569 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 1072459001570 TPP-binding site [chemical binding]; other site 1072459001571 hydroxypyruvate isomerase; Provisional; Region: PRK09997 1072459001572 tartronate semialdehyde reductase; Provisional; Region: PRK15059 1072459001573 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1072459001574 nucleobase-cation-symport-1 (NCS1) transporters; solute-binding domain; Region: SLC-NCS1sbd; cd10323 1072459001575 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1072459001576 Na binding site [ion binding]; other site 1072459001577 substrate binding site [chemical binding]; other site 1072459001578 allantoinase; Provisional; Region: PRK08044 1072459001579 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 1072459001580 active site 1072459001581 putative uracil/xanthine transporter; Provisional; Region: PRK11412 1072459001582 glycerate kinase II; Provisional; Region: PRK09932 1072459001583 putative allantoin catabolism protein; Region: ura-cupin; TIGR03214 1072459001584 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 1072459001585 Cupin domain; Region: Cupin_2; cl17218 1072459001586 allantoate amidohydrolase; Region: AllC; TIGR03176 1072459001587 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1072459001588 active site 1072459001589 metal binding site [ion binding]; metal-binding site 1072459001590 dimer interface [polypeptide binding]; other site 1072459001591 ureidoglycolate dehydrogenase; Provisional; Region: PRK15025 1072459001592 membrane protein FdrA; Validated; Region: PRK06091 1072459001593 CoA binding domain; Region: CoA_binding; pfam02629 1072459001594 CoA-ligase; Region: Ligase_CoA; pfam00549 1072459001595 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 1072459001596 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 1072459001597 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 1072459001598 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1072459001599 putative substrate binding site [chemical binding]; other site 1072459001600 nucleotide binding site [chemical binding]; other site 1072459001601 nucleotide binding site [chemical binding]; other site 1072459001602 homodimer interface [polypeptide binding]; other site 1072459001603 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1072459001604 ATP-grasp domain; Region: ATP-grasp; pfam02222 1072459001605 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1072459001606 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1072459001607 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1072459001608 putative active site [active] 1072459001609 putative metal binding site [ion binding]; other site 1072459001610 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1072459001611 substrate binding site [chemical binding]; other site 1072459001612 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1072459001613 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1072459001614 active site 1072459001615 HIGH motif; other site 1072459001616 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1072459001617 KMSKS motif; other site 1072459001618 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 1072459001619 tRNA binding surface [nucleotide binding]; other site 1072459001620 anticodon binding site; other site 1072459001621 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1072459001622 ribosome-associated protein; Provisional; Region: PRK11507 1072459001623 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 1072459001624 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1072459001625 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1072459001626 homodimer interface [polypeptide binding]; other site 1072459001627 NADP binding site [chemical binding]; other site 1072459001628 substrate binding site [chemical binding]; other site 1072459001629 type-1 fimbrial protein subunit A; Provisional; Region: PRK15194 1072459001630 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 1072459001631 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1072459001632 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1072459001633 outer membrane usher protein FimD; Provisional; Region: PRK15198 1072459001634 PapC N-terminal domain; Region: PapC_N; pfam13954 1072459001635 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1072459001636 PapC C-terminal domain; Region: PapC_C; pfam13953 1072459001637 fimbrial-like adhesin; Provisional; Region: fimH; PRK15199 1072459001638 fimbrial-like adhesin protein SfmF; Provisional; Region: PRK09934 1072459001639 transcriptional regulator FimZ; Provisional; Region: PRK09935 1072459001640 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1072459001641 active site 1072459001642 phosphorylation site [posttranslational modification] 1072459001643 intermolecular recognition site; other site 1072459001644 dimerization interface [polypeptide binding]; other site 1072459001645 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1072459001646 DNA binding residues [nucleotide binding] 1072459001647 dimerization interface [polypeptide binding]; other site 1072459001648 putative transposase OrfB; Reviewed; Region: PHA02517 1072459001649 HTH-like domain; Region: HTH_21; pfam13276 1072459001650 Integrase core domain; Region: rve; pfam00665 1072459001651 Integrase core domain; Region: rve_3; pfam13683 1072459001652 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1072459001653 hypothetical protein; Provisional; Region: PRK09741 1072459001654 Protein of unknown function (DUF1364); Region: DUF1364; pfam07102 1072459001655 endodeoxyribonuclease RUS; Reviewed; Region: PRK09786 1072459001656 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 1072459001657 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 1072459001658 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 1072459001659 Protein of unknown function (DUF523); Region: DUF523; pfam04463 1072459001660 Uncharacterized conserved protein [Function unknown]; Region: COG3272 1072459001661 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 1072459001662 transcriptional regulator YdeO; Provisional; Region: PRK09940 1072459001663 Pleckstrin homology-like domain; Region: PH-like; cl17171 1072459001664 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1072459001665 Lysis protein S; Region: Lysis_S; pfam04971 1072459001666 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1072459001667 catalytic residues [active] 1072459001668 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 1072459001669 Bor protein; Region: Lambda_Bor; pfam06291 1072459001670 Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471 1072459001671 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 1072459001672 gpW; Region: gpW; pfam02831 1072459001673 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 1072459001674 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 1072459001675 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 1072459001676 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1072459001677 tandem repeat interface [polypeptide binding]; other site 1072459001678 oligomer interface [polypeptide binding]; other site 1072459001679 active site residues [active] 1072459001680 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 1072459001681 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 1072459001682 DNA packaging protein FI; Region: Packaging_FI; pfam14000 1072459001683 HTH-like domain; Region: HTH_21; pfam13276 1072459001684 Integrase core domain; Region: rve; pfam00665 1072459001685 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1072459001686 Integrase core domain; Region: rve_3; pfam13683 1072459001687 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1072459001688 Transposase; Region: HTH_Tnp_1; cl17663 1072459001689 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 1072459001690 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 1072459001691 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 1072459001692 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 1072459001693 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 1072459001694 phage minor tail protein G; Region: phage_lambda_G; TIGR01674 1072459001695 Minor tail protein T; Region: Phage_tail_T; pfam06223 1072459001696 Phage-related minor tail protein [Function unknown]; Region: COG5281 1072459001697 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 1072459001698 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 1072459001699 Phage-related protein [Function unknown]; Region: COG4718 1072459001700 Phage-related protein [Function unknown]; Region: gp18; COG4672 1072459001701 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 1072459001702 MPN+ (JAMM) motif; other site 1072459001703 Zinc-binding site [ion binding]; other site 1072459001704 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1072459001705 NlpC/P60 family; Region: NLPC_P60; cl17555 1072459001706 Phage-related protein, tail component [Function unknown]; Region: COG4723 1072459001707 Phage-related protein, tail component [Function unknown]; Region: COG4733 1072459001708 Putative phage tail protein; Region: Phage-tail_3; pfam13550 1072459001709 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 1072459001710 Fibronectin type III protein; Region: DUF3672; pfam12421 1072459001711 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 1072459001712 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 1072459001713 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1072459001714 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1072459001715 S-adenosylmethionine binding site [chemical binding]; other site 1072459001716 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1072459001717 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1072459001718 TAP-like protein; Region: Abhydrolase_4; pfam08386 1072459001719 outer membrane protease; Reviewed; Region: PRK10993 1072459001720 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1072459001721 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1072459001722 hypothetical protein; Provisional; Region: PRK09936 1072459001723 bacteriophage N4 receptor, outer membrane subunit; Provisional; Region: PRK09782 1072459001724 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1072459001725 TPR motif; other site 1072459001726 binding surface 1072459001727 Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283 1072459001728 bacteriophage N4 adsorption protein B; Provisional; Region: PRK14716 1072459001729 active site 1072459001730 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 1072459001731 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1072459001732 sensor kinase CusS; Provisional; Region: PRK09835 1072459001733 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1072459001734 dimerization interface [polypeptide binding]; other site 1072459001735 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1072459001736 dimer interface [polypeptide binding]; other site 1072459001737 phosphorylation site [posttranslational modification] 1072459001738 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1072459001739 ATP binding site [chemical binding]; other site 1072459001740 Mg2+ binding site [ion binding]; other site 1072459001741 G-X-G motif; other site 1072459001742 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 1072459001743 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1072459001744 active site 1072459001745 phosphorylation site [posttranslational modification] 1072459001746 intermolecular recognition site; other site 1072459001747 dimerization interface [polypeptide binding]; other site 1072459001748 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1072459001749 DNA binding site [nucleotide binding] 1072459001750 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 1072459001751 periplasmic copper-binding protein; Provisional; Region: PRK09838 1072459001752 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 1072459001753 HlyD family secretion protein; Region: HlyD_3; pfam13437 1072459001754 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 1072459001755 phenylalanine transporter; Provisional; Region: PRK10249 1072459001756 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1072459001757 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1072459001758 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1072459001759 dimer interface [polypeptide binding]; other site 1072459001760 FMN binding site [chemical binding]; other site 1072459001761 hypothetical protein; Provisional; Region: PRK10250 1072459001762 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 1072459001763 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 1072459001764 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1072459001765 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1072459001766 Hok/gef family; Region: HOK_GEF; pfam01848 1072459001767 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 1072459001768 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1072459001769 outer membrane receptor FepA; Provisional; Region: PRK13524 1072459001770 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1072459001771 N-terminal plug; other site 1072459001772 ligand-binding site [chemical binding]; other site 1072459001773 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 1072459001774 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 1072459001775 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1072459001776 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 1072459001777 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1072459001778 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1072459001779 acyl-activating enzyme (AAE) consensus motif; other site 1072459001780 AMP binding site [chemical binding]; other site 1072459001781 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1072459001782 LPS O-antigen length regulator; Provisional; Region: PRK10381 1072459001783 Chain length determinant protein; Region: Wzz; pfam02706 1072459001784 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1072459001785 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 1072459001786 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1072459001787 Walker A/P-loop; other site 1072459001788 ATP binding site [chemical binding]; other site 1072459001789 Q-loop/lid; other site 1072459001790 ABC transporter signature motif; other site 1072459001791 Walker B; other site 1072459001792 D-loop; other site 1072459001793 H-loop/switch region; other site 1072459001794 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1072459001795 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1072459001796 ABC-ATPase subunit interface; other site 1072459001797 dimer interface [polypeptide binding]; other site 1072459001798 putative PBP binding regions; other site 1072459001799 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1072459001800 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1072459001801 ABC-ATPase subunit interface; other site 1072459001802 dimer interface [polypeptide binding]; other site 1072459001803 putative PBP binding regions; other site 1072459001804 enterobactin exporter EntS; Provisional; Region: PRK10489 1072459001805 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459001806 putative substrate translocation pore; other site 1072459001807 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 1072459001808 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1072459001809 siderophore binding site; other site 1072459001810 isochorismate synthase EntC; Provisional; Region: PRK15016 1072459001811 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1072459001812 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 1072459001813 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1072459001814 acyl-activating enzyme (AAE) consensus motif; other site 1072459001815 active site 1072459001816 AMP binding site [chemical binding]; other site 1072459001817 substrate binding site [chemical binding]; other site 1072459001818 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 1072459001819 hydrophobic substrate binding pocket; other site 1072459001820 Isochorismatase family; Region: Isochorismatase; pfam00857 1072459001821 active site 1072459001822 conserved cis-peptide bond; other site 1072459001823 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1072459001824 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 1072459001825 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 1072459001826 putative NAD(P) binding site [chemical binding]; other site 1072459001827 active site 1072459001828 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1072459001829 CoenzymeA binding site [chemical binding]; other site 1072459001830 subunit interaction site [polypeptide binding]; other site 1072459001831 PHB binding site; other site 1072459001832 carbon starvation protein A; Provisional; Region: PRK15015 1072459001833 Carbon starvation protein CstA; Region: CstA; pfam02554 1072459001834 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1072459001835 Uncharacterized small protein [Function unknown]; Region: COG2879 1072459001836 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1072459001837 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 1072459001838 putative active site [active] 1072459001839 metal binding site [ion binding]; metal-binding site 1072459001840 methionine aminotransferase; Validated; Region: PRK09082 1072459001841 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1072459001842 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1072459001843 homodimer interface [polypeptide binding]; other site 1072459001844 catalytic residue [active] 1072459001845 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1072459001846 ParB-like nuclease domain; Region: ParBc; pfam02195 1072459001847 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 1072459001848 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1072459001849 Active Sites [active] 1072459001850 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 1072459001851 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 1072459001852 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1072459001853 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1072459001854 dimerization interface [polypeptide binding]; other site 1072459001855 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 1072459001856 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1072459001857 dimerization domain [polypeptide binding]; other site 1072459001858 dimer interface [polypeptide binding]; other site 1072459001859 catalytic residues [active] 1072459001860 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 1072459001861 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1072459001862 dimer interface [polypeptide binding]; other site 1072459001863 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1072459001864 catalytic triad [active] 1072459001865 peroxidatic and resolving cysteines [active] 1072459001866 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1072459001867 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1072459001868 catalytic residue [active] 1072459001869 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1072459001870 catalytic residues [active] 1072459001871 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1072459001872 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1072459001873 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1072459001874 Ligand Binding Site [chemical binding]; other site 1072459001875 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 1072459001876 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1072459001877 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 1072459001878 B1 nucleotide binding pocket [chemical binding]; other site 1072459001879 B2 nucleotide binding pocket [chemical binding]; other site 1072459001880 CAS motifs; other site 1072459001881 active site 1072459001882 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1072459001883 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1072459001884 transmembrane helices; other site 1072459001885 triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096 1072459001886 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 1072459001887 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 1072459001888 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1072459001889 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 1072459001890 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 1072459001891 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 1072459001892 putative active site [active] 1072459001893 (T/H)XGH motif; other site 1072459001894 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 1072459001895 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1072459001896 putative active site [active] 1072459001897 heme pocket [chemical binding]; other site 1072459001898 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1072459001899 ATP binding site [chemical binding]; other site 1072459001900 Mg2+ binding site [ion binding]; other site 1072459001901 G-X-G motif; other site 1072459001902 two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046 1072459001903 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1072459001904 active site 1072459001905 phosphorylation site [posttranslational modification] 1072459001906 intermolecular recognition site; other site 1072459001907 dimerization interface [polypeptide binding]; other site 1072459001908 Transcriptional regulator; Region: CitT; pfam12431 1072459001909 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 1072459001910 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1072459001911 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 1072459001912 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1072459001913 DNA-binding site [nucleotide binding]; DNA binding site 1072459001914 RNA-binding motif; other site 1072459001915 chromosome condensation membrane protein; Provisional; Region: PRK14196 1072459001916 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1072459001917 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 1072459001918 putative active site [active] 1072459001919 catalytic triad [active] 1072459001920 putative dimer interface [polypeptide binding]; other site 1072459001921 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 1072459001922 lipoyl synthase; Provisional; Region: PRK05481 1072459001923 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1072459001924 FeS/SAM binding site; other site 1072459001925 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 1072459001926 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1072459001927 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1072459001928 substrate binding pocket [chemical binding]; other site 1072459001929 dimerization interface [polypeptide binding]; other site 1072459001930 lipoate-protein ligase B; Provisional; Region: PRK14342 1072459001931 hypothetical protein; Provisional; Region: PRK04998 1072459001932 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 1072459001933 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1072459001934 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1072459001935 rare lipoprotein A; Provisional; Region: PRK10672 1072459001936 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1072459001937 Sporulation related domain; Region: SPOR; pfam05036 1072459001938 cell wall shape-determining protein; Provisional; Region: PRK10794 1072459001939 penicillin-binding protein 2; Provisional; Region: PRK10795 1072459001940 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1072459001941 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1072459001942 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 1072459001943 ribosome-associated protein; Provisional; Region: PRK11538 1072459001944 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1072459001945 catalytic core [active] 1072459001946 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1072459001947 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1072459001948 active site 1072459001949 (T/H)XGH motif; other site 1072459001950 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1072459001951 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1072459001952 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 1072459001953 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1072459001954 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1072459001955 HIGH motif; other site 1072459001956 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1072459001957 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1072459001958 active site 1072459001959 KMSKS motif; other site 1072459001960 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1072459001961 tRNA binding surface [nucleotide binding]; other site 1072459001962 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1072459001963 hypothetical protein; Provisional; Region: PRK11032 1072459001964 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 1072459001965 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1072459001966 active site 1072459001967 tetramer interface [polypeptide binding]; other site 1072459001968 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1072459001969 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1072459001970 Walker A/P-loop; other site 1072459001971 ATP binding site [chemical binding]; other site 1072459001972 Q-loop/lid; other site 1072459001973 ABC transporter signature motif; other site 1072459001974 Walker B; other site 1072459001975 D-loop; other site 1072459001976 H-loop/switch region; other site 1072459001977 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1072459001978 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1072459001979 dimer interface [polypeptide binding]; other site 1072459001980 conserved gate region; other site 1072459001981 putative PBP binding loops; other site 1072459001982 ABC-ATPase subunit interface; other site 1072459001983 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1072459001984 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1072459001985 dimer interface [polypeptide binding]; other site 1072459001986 conserved gate region; other site 1072459001987 putative PBP binding loops; other site 1072459001988 ABC-ATPase subunit interface; other site 1072459001989 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1072459001990 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1072459001991 substrate binding pocket [chemical binding]; other site 1072459001992 membrane-bound complex binding site; other site 1072459001993 hinge residues; other site 1072459001994 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1072459001995 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1072459001996 putative active site [active] 1072459001997 catalytic triad [active] 1072459001998 putative dimer interface [polypeptide binding]; other site 1072459001999 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 1072459002000 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1072459002001 Transporter associated domain; Region: CorC_HlyC; smart01091 1072459002002 metal-binding heat shock protein; Provisional; Region: PRK00016 1072459002003 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1072459002004 PhoH-like protein; Region: PhoH; pfam02562 1072459002005 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 1072459002006 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1072459002007 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1072459002008 FeS/SAM binding site; other site 1072459002009 TRAM domain; Region: TRAM; pfam01938 1072459002010 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 1072459002011 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1072459002012 asparagine synthetase B; Provisional; Region: asnB; PRK09431 1072459002013 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1072459002014 active site 1072459002015 dimer interface [polypeptide binding]; other site 1072459002016 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1072459002017 Ligand Binding Site [chemical binding]; other site 1072459002018 Molecular Tunnel; other site 1072459002019 UMP phosphatase; Provisional; Region: PRK10444 1072459002020 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1072459002021 active site 1072459002022 motif I; other site 1072459002023 motif II; other site 1072459002024 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1072459002025 MarR family; Region: MarR; pfam01047 1072459002026 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1072459002027 ROK family; Region: ROK; pfam00480 1072459002028 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 1072459002029 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1072459002030 active site 1072459002031 dimer interface [polypeptide binding]; other site 1072459002032 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1072459002033 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1072459002034 active site 1072459002035 trimer interface [polypeptide binding]; other site 1072459002036 allosteric site; other site 1072459002037 active site lid [active] 1072459002038 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1072459002039 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 1072459002040 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1072459002041 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1072459002042 active site turn [active] 1072459002043 phosphorylation site [posttranslational modification] 1072459002044 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1072459002045 HPr interaction site; other site 1072459002046 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1072459002047 active site 1072459002048 phosphorylation site [posttranslational modification] 1072459002049 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1072459002050 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1072459002051 active site 1072459002052 HIGH motif; other site 1072459002053 nucleotide binding site [chemical binding]; other site 1072459002054 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 1072459002055 KMSKS motif; other site 1072459002056 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1072459002057 outer membrane porin, OprD family; Region: OprD; pfam03573 1072459002058 YbfN-like lipoprotein; Region: YbfN; pfam13982 1072459002059 ferric uptake regulator; Provisional; Region: fur; PRK09462 1072459002060 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1072459002061 metal binding site 2 [ion binding]; metal-binding site 1072459002062 putative DNA binding helix; other site 1072459002063 metal binding site 1 [ion binding]; metal-binding site 1072459002064 dimer interface [polypeptide binding]; other site 1072459002065 structural Zn2+ binding site [ion binding]; other site 1072459002066 flavodoxin FldA; Validated; Region: PRK09267 1072459002067 LexA regulated protein; Provisional; Region: PRK11675 1072459002068 acyl-CoA esterase; Provisional; Region: PRK10673 1072459002069 PGAP1-like protein; Region: PGAP1; pfam07819 1072459002070 replication initiation regulator SeqA; Provisional; Region: PRK11187 1072459002071 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 1072459002072 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1072459002073 active site 1072459002074 substrate binding site [chemical binding]; other site 1072459002075 metal binding site [ion binding]; metal-binding site 1072459002076 Protein of unknown function DUF2625; Region: DUF2625; pfam10946 1072459002077 putrescine transporter; Provisional; Region: potE; PRK10655 1072459002078 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1072459002079 ornithine decarboxylase; Provisional; Region: PRK13578 1072459002080 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1072459002081 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1072459002082 homodimer interface [polypeptide binding]; other site 1072459002083 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1072459002084 catalytic residue [active] 1072459002085 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1072459002086 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1072459002087 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1072459002088 active site 1072459002089 phosphorylation site [posttranslational modification] 1072459002090 intermolecular recognition site; other site 1072459002091 dimerization interface [polypeptide binding]; other site 1072459002092 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1072459002093 DNA binding site [nucleotide binding] 1072459002094 sensor protein KdpD; Provisional; Region: PRK10490 1072459002095 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1072459002096 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1072459002097 Ligand Binding Site [chemical binding]; other site 1072459002098 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1072459002099 GAF domain; Region: GAF_3; pfam13492 1072459002100 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1072459002101 dimer interface [polypeptide binding]; other site 1072459002102 phosphorylation site [posttranslational modification] 1072459002103 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1072459002104 ATP binding site [chemical binding]; other site 1072459002105 Mg2+ binding site [ion binding]; other site 1072459002106 G-X-G motif; other site 1072459002107 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 1072459002108 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1072459002109 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1072459002110 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1072459002111 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 1072459002112 hypothetical protein; Provisional; Region: PRK10167 1072459002113 Uncharacterized conserved protein [Function unknown]; Region: COG3272 1072459002114 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 1072459002115 DNA photolyase; Region: DNA_photolyase; pfam00875 1072459002116 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1072459002117 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459002118 putative substrate translocation pore; other site 1072459002119 POT family; Region: PTR2; pfam00854 1072459002120 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1072459002121 metal-binding protein; Provisional; Region: PRK10799 1072459002122 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1072459002123 sensor histidine kinase inhibitor, KipI family; Region: TIGR00370 1072459002124 biotin-dependent carboxylase uncharacterized domain; Region: urea_amlyse_rel; TIGR00724 1072459002125 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 1072459002126 putative active site [active] 1072459002127 endonuclease VIII; Provisional; Region: PRK10445 1072459002128 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 1072459002129 DNA binding site [nucleotide binding] 1072459002130 catalytic residue [active] 1072459002131 putative catalytic residues [active] 1072459002132 H2TH interface [polypeptide binding]; other site 1072459002133 intercalation triad [nucleotide binding]; other site 1072459002134 substrate specificity determining residue; other site 1072459002135 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1072459002136 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1072459002137 Putative ammonia monooxygenase; Region: AmoA; pfam05145 1072459002138 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1072459002139 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1072459002140 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1072459002141 DNA-binding site [nucleotide binding]; DNA binding site 1072459002142 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1072459002143 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1072459002144 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 1072459002145 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 1072459002146 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1072459002147 putative NAD(P) binding site [chemical binding]; other site 1072459002148 catalytic Zn binding site [ion binding]; other site 1072459002149 structural Zn binding site [ion binding]; other site 1072459002150 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1072459002151 classical (c) SDRs; Region: SDR_c; cd05233 1072459002152 NAD(P) binding site [chemical binding]; other site 1072459002153 active site 1072459002154 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1072459002155 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1072459002156 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1072459002157 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1072459002158 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1072459002159 DctM-like transporters; Region: DctM; pfam06808 1072459002160 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1072459002161 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1072459002162 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1072459002163 dimer interface [polypeptide binding]; other site 1072459002164 active site 1072459002165 citrylCoA binding site [chemical binding]; other site 1072459002166 NADH binding [chemical binding]; other site 1072459002167 cationic pore residues; other site 1072459002168 oxalacetate/citrate binding site [chemical binding]; other site 1072459002169 coenzyme A binding site [chemical binding]; other site 1072459002170 catalytic triad [active] 1072459002171 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 1072459002172 Iron-sulfur protein interface; other site 1072459002173 proximal quinone binding site [chemical binding]; other site 1072459002174 SdhD (CybS) interface [polypeptide binding]; other site 1072459002175 proximal heme binding site [chemical binding]; other site 1072459002176 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 1072459002177 SdhC subunit interface [polypeptide binding]; other site 1072459002178 proximal heme binding site [chemical binding]; other site 1072459002179 cardiolipin binding site; other site 1072459002180 Iron-sulfur protein interface; other site 1072459002181 proximal quinone binding site [chemical binding]; other site 1072459002182 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 1072459002183 L-aspartate oxidase; Provisional; Region: PRK06175 1072459002184 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1072459002185 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1072459002186 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1072459002187 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1072459002188 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1072459002189 TPP-binding site [chemical binding]; other site 1072459002190 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1072459002191 dimer interface [polypeptide binding]; other site 1072459002192 PYR/PP interface [polypeptide binding]; other site 1072459002193 TPP binding site [chemical binding]; other site 1072459002194 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1072459002195 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1072459002196 E3 interaction surface; other site 1072459002197 lipoyl attachment site [posttranslational modification]; other site 1072459002198 e3 binding domain; Region: E3_binding; pfam02817 1072459002199 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1072459002200 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1072459002201 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1072459002202 CoA-ligase; Region: Ligase_CoA; pfam00549 1072459002203 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1072459002204 CoA binding domain; Region: CoA_binding; smart00881 1072459002205 CoA-ligase; Region: Ligase_CoA; pfam00549 1072459002206 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 1072459002207 urocanate hydratase; Provisional; Region: PRK05414 1072459002208 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1072459002209 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1072459002210 HutD; Region: HutD; pfam05962 1072459002211 imidazolonepropionase; Validated; Region: PRK09356 1072459002212 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1072459002213 active site 1072459002214 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 1072459002215 putative active site [active] 1072459002216 putative metal binding site [ion binding]; other site 1072459002217 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1072459002218 active sites [active] 1072459002219 tetramer interface [polypeptide binding]; other site 1072459002220 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1072459002221 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1072459002222 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1072459002223 dimerization interface [polypeptide binding]; other site 1072459002224 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1072459002225 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 1072459002226 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1072459002227 homodimer interface [polypeptide binding]; other site 1072459002228 Walker A motif; other site 1072459002229 ATP binding site [chemical binding]; other site 1072459002230 hydroxycobalamin binding site [chemical binding]; other site 1072459002231 Walker B motif; other site 1072459002232 putative fumarate hydratase; Provisional; Region: PRK15392 1072459002233 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 1072459002234 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1072459002235 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1072459002236 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1072459002237 Domain of unknown function (DUF4387); Region: DUF4387; pfam14330 1072459002238 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 1072459002239 Methylaspartate ammonia-lyase [Amino acid transport and metabolism]; Region: Mal; COG3799 1072459002240 Methylaspartate ammonia lyase (3-methylaspartase, MAL) is a homodimeric enzyme, catalyzing the magnesium-dependent reversible alpha,beta-elimination of ammonia from L-threo-(2S,3S)-3-methylaspartic acid to mesaconic acid. This reaction is part of the...; Region: MAL; cd03314 1072459002241 dimer interface [polypeptide binding]; other site 1072459002242 active site 1072459002243 Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to...; Region: Glm_e; cd00245 1072459002244 substrate binding site [chemical binding]; other site 1072459002245 B12 cofactor binding site [chemical binding]; other site 1072459002246 heterodimer (sigma-epsilon) interface [polypeptide binding]; other site 1072459002247 homodimer (epsilon-epsilon) interface [polypeptide binding]; other site 1072459002248 conserved hypothetical protein; Region: glmL_fam; TIGR01319 1072459002249 B12 binding domain of glutamate mutase (Glm). Glutamate mutase catalysis the conversion of (S)-glutamate with (2S,3S)-3-methylaspartate. The rearrangement reaction is initiated by the extraction of a hydrogen from the protein-bound substrate by a 5'...; Region: Glm_B12_BD; cd02072 1072459002250 B12 binding site [chemical binding]; other site 1072459002251 heterodimer interface [polypeptide binding]; other site 1072459002252 cobalt ligand [ion binding]; other site 1072459002253 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1072459002254 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 1072459002255 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 1072459002256 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 1072459002257 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 1072459002258 hypothetical protein; Provisional; Region: PRK10588 1072459002259 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1072459002260 active site 1072459002261 colicin uptake protein TolQ; Provisional; Region: PRK10801 1072459002262 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1072459002263 colicin uptake protein TolR; Provisional; Region: PRK11024 1072459002264 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 1072459002265 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 1072459002266 TolA C-terminal; Region: TolA; pfam06519 1072459002267 translocation protein TolB; Provisional; Region: tolB; PRK03629 1072459002268 TolB amino-terminal domain; Region: TolB_N; pfam04052 1072459002269 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1072459002270 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1072459002271 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1072459002272 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 1072459002273 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1072459002274 ligand binding site [chemical binding]; other site 1072459002275 tol-pal system protein YbgF; Provisional; Region: PRK10803 1072459002276 Tetratricopeptide repeat; Region: TPR_6; pfam13174 1072459002277 Tetratricopeptide repeat; Region: TPR_6; pfam13174 1072459002278 quinolinate synthetase; Provisional; Region: PRK09375 1072459002279 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 1072459002280 zinc transporter ZitB; Provisional; Region: PRK03557 1072459002281 YbgS-like protein; Region: YbgS; pfam13985 1072459002282 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1072459002283 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1072459002284 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1072459002285 catalytic core [active] 1072459002286 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1072459002287 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1072459002288 active site 1072459002289 catalytic residues [active] 1072459002290 galactokinase; Provisional; Region: PRK05101 1072459002291 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1072459002292 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1072459002293 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 1072459002294 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 1072459002295 dimer interface [polypeptide binding]; other site 1072459002296 active site 1072459002297 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 1072459002298 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1072459002299 NAD binding site [chemical binding]; other site 1072459002300 homodimer interface [polypeptide binding]; other site 1072459002301 active site 1072459002302 substrate binding site [chemical binding]; other site 1072459002303 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 1072459002304 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 1072459002305 Walker A/P-loop; other site 1072459002306 ATP binding site [chemical binding]; other site 1072459002307 Q-loop/lid; other site 1072459002308 ABC transporter signature motif; other site 1072459002309 Walker B; other site 1072459002310 D-loop; other site 1072459002311 H-loop/switch region; other site 1072459002312 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1072459002313 Walker A/P-loop; other site 1072459002314 ATP binding site [chemical binding]; other site 1072459002315 Q-loop/lid; other site 1072459002316 ABC transporter signature motif; other site 1072459002317 Walker B; other site 1072459002318 D-loop; other site 1072459002319 H-loop/switch region; other site 1072459002320 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 1072459002321 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 1072459002322 molybdenum-pterin binding domain; Region: Mop; TIGR00638 1072459002323 TOBE domain; Region: TOBE; pfam03459 1072459002324 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 1072459002325 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 1072459002326 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1072459002327 substrate binding pocket [chemical binding]; other site 1072459002328 membrane-bound complex binding site; other site 1072459002329 hinge residues; other site 1072459002330 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1072459002331 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1072459002332 dimer interface [polypeptide binding]; other site 1072459002333 conserved gate region; other site 1072459002334 putative PBP binding loops; other site 1072459002335 ABC-ATPase subunit interface; other site 1072459002336 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 1072459002337 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1072459002338 Walker A/P-loop; other site 1072459002339 ATP binding site [chemical binding]; other site 1072459002340 Q-loop/lid; other site 1072459002341 ABC transporter signature motif; other site 1072459002342 Walker B; other site 1072459002343 D-loop; other site 1072459002344 H-loop/switch region; other site 1072459002345 molybdenum-pterin binding domain; Region: Mop; TIGR00638 1072459002346 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 1072459002347 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1072459002348 motif II; other site 1072459002349 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1072459002350 6-phosphogluconolactonase; Provisional; Region: PRK11028 1072459002351 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1072459002352 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1072459002353 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1072459002354 putative dimerization interface [polypeptide binding]; other site 1072459002355 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 1072459002356 putative hydratase; Provisional; Region: PRK11413 1072459002357 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1072459002358 substrate binding site [chemical binding]; other site 1072459002359 ligand binding site [chemical binding]; other site 1072459002360 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 1072459002361 substrate binding site [chemical binding]; other site 1072459002362 acyl-CoA thioesterase; Provisional; Region: PRK10531 1072459002363 putative pectinesterase; Region: PLN02432; cl01911 1072459002364 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 1072459002365 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 1072459002366 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1072459002367 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 1072459002368 dimer interface [polypeptide binding]; other site 1072459002369 active site 1072459002370 Int/Topo IB signature motif; other site 1072459002371 Protein of unknown function (DUF551); Region: DUF551; pfam04448 1072459002372 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 1072459002373 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 1072459002374 Protein of unknown function (DUF2737); Region: DUF2737; pfam10930 1072459002375 Protein of unknown function (DUF2856); Region: DUF2856; pfam11043 1072459002376 AAA domain; Region: AAA_22; pfam13401 1072459002377 RNA helicase; Region: RNA_helicase; pfam00910 1072459002378 Bacteriophage lambda Kil protein; Region: Lambda_Kil; pfam06301 1072459002379 putative transposase OrfB; Reviewed; Region: PHA02517 1072459002380 HTH-like domain; Region: HTH_21; pfam13276 1072459002381 Integrase core domain; Region: rve; pfam00665 1072459002382 Integrase core domain; Region: rve_3; pfam13683 1072459002383 Mnt; Region: mnt; PHA01513 1072459002384 Arc-like DNA binding domain; Region: Arc; pfam03869 1072459002385 KilA-N domain; Region: KilA-N; pfam04383 1072459002386 Phage anti-repressor protein [Transcription]; Region: COG3561 1072459002387 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1072459002388 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1072459002389 trimer interface [polypeptide binding]; other site 1072459002390 active site 1072459002391 substrate binding site [chemical binding]; other site 1072459002392 CoA binding site [chemical binding]; other site 1072459002393 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1072459002394 substrate binding site [chemical binding]; other site 1072459002395 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 1072459002396 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1072459002397 inhibitor-cofactor binding pocket; inhibition site 1072459002398 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1072459002399 catalytic residue [active] 1072459002400 biotin synthase; Provisional; Region: PRK15108 1072459002401 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1072459002402 FeS/SAM binding site; other site 1072459002403 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 1072459002404 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1072459002405 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1072459002406 substrate-cofactor binding pocket; other site 1072459002407 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1072459002408 catalytic residue [active] 1072459002409 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 1072459002410 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1072459002411 S-adenosylmethionine binding site [chemical binding]; other site 1072459002412 AAA domain; Region: AAA_26; pfam13500 1072459002413 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1072459002414 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 1072459002415 ADP binding site [chemical binding]; other site 1072459002416 excinuclease ABC subunit B; Provisional; Region: PRK05298 1072459002417 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1072459002418 ATP binding site [chemical binding]; other site 1072459002419 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1072459002420 nucleotide binding region [chemical binding]; other site 1072459002421 ATP-binding site [chemical binding]; other site 1072459002422 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1072459002423 UvrB/uvrC motif; Region: UVR; pfam02151 1072459002424 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1072459002425 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1072459002426 putative substrate binding pocket [chemical binding]; other site 1072459002427 dimer interface [polypeptide binding]; other site 1072459002428 phosphate binding site [ion binding]; other site 1072459002429 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1072459002430 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1072459002431 FeS/SAM binding site; other site 1072459002432 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1072459002433 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1072459002434 MPT binding site; other site 1072459002435 trimer interface [polypeptide binding]; other site 1072459002436 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1072459002437 trimer interface [polypeptide binding]; other site 1072459002438 dimer interface [polypeptide binding]; other site 1072459002439 putative active site [active] 1072459002440 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1072459002441 MoaE interaction surface [polypeptide binding]; other site 1072459002442 MoeB interaction surface [polypeptide binding]; other site 1072459002443 thiocarboxylated glycine; other site 1072459002444 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1072459002445 MoaE homodimer interface [polypeptide binding]; other site 1072459002446 MoaD interaction [polypeptide binding]; other site 1072459002447 active site residues [active] 1072459002448 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1072459002449 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1072459002450 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1072459002451 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1072459002452 Predicted integral membrane protein [Function unknown]; Region: COG0392 1072459002453 cardiolipin synthase 2; Provisional; Region: PRK11263 1072459002454 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1072459002455 putative active site [active] 1072459002456 catalytic site [active] 1072459002457 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 1072459002458 putative active site [active] 1072459002459 catalytic site [active] 1072459002460 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 1072459002461 putative catalytic site [active] 1072459002462 putative metal binding site [ion binding]; other site 1072459002463 putative phosphate binding site [ion binding]; other site 1072459002464 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 1072459002465 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1072459002466 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1072459002467 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1072459002468 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1072459002469 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1072459002470 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1072459002471 Walker A/P-loop; other site 1072459002472 ATP binding site [chemical binding]; other site 1072459002473 Q-loop/lid; other site 1072459002474 ABC transporter signature motif; other site 1072459002475 Walker B; other site 1072459002476 D-loop; other site 1072459002477 H-loop/switch region; other site 1072459002478 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1072459002479 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1072459002480 Walker A/P-loop; other site 1072459002481 ATP binding site [chemical binding]; other site 1072459002482 Q-loop/lid; other site 1072459002483 ABC transporter signature motif; other site 1072459002484 Walker B; other site 1072459002485 D-loop; other site 1072459002486 H-loop/switch region; other site 1072459002487 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 1072459002488 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1072459002489 HlyD family secretion protein; Region: HlyD_3; pfam13437 1072459002490 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 1072459002491 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 1072459002492 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 1072459002493 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1072459002494 ATP binding site [chemical binding]; other site 1072459002495 Mg++ binding site [ion binding]; other site 1072459002496 motif III; other site 1072459002497 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1072459002498 nucleotide binding region [chemical binding]; other site 1072459002499 ATP-binding site [chemical binding]; other site 1072459002500 SopA-like central domain; Region: SopA; pfam13981 1072459002501 SopA-like catalytic domain; Region: SopA_C; pfam13979 1072459002502 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 1072459002503 DEAD_2; Region: DEAD_2; pfam06733 1072459002504 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1072459002505 glycosyl transferase family protein; Provisional; Region: PRK08136 1072459002506 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1072459002507 putative dehydrogenase; Provisional; Region: PRK10098 1072459002508 hypothetical protein; Provisional; Region: PRK10259 1072459002509 hypothetical protein; Provisional; Region: PRK11019 1072459002510 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 1072459002511 catecholate siderophore receptor Fiu; Provisional; Region: PRK09840 1072459002512 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1072459002513 N-terminal plug; other site 1072459002514 ligand-binding site [chemical binding]; other site 1072459002515 hypothetical protein; Provisional; Region: PRK10259 1072459002516 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 1072459002517 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 1072459002518 putative mechanosensitive channel protein; Provisional; Region: PRK11465 1072459002519 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1072459002520 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 1072459002521 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1072459002522 Walker A/P-loop; other site 1072459002523 ATP binding site [chemical binding]; other site 1072459002524 Q-loop/lid; other site 1072459002525 ABC transporter signature motif; other site 1072459002526 Walker B; other site 1072459002527 D-loop; other site 1072459002528 H-loop/switch region; other site 1072459002529 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1072459002530 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1072459002531 dimer interface [polypeptide binding]; other site 1072459002532 conserved gate region; other site 1072459002533 putative PBP binding loops; other site 1072459002534 ABC-ATPase subunit interface; other site 1072459002535 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 1072459002536 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1072459002537 substrate binding pocket [chemical binding]; other site 1072459002538 membrane-bound complex binding site; other site 1072459002539 hinge residues; other site 1072459002540 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1072459002541 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1072459002542 dimerization interface [polypeptide binding]; other site 1072459002543 DPS ferroxidase diiron center [ion binding]; other site 1072459002544 ion pore; other site 1072459002545 threonine and homoserine efflux system; Provisional; Region: PRK10532 1072459002546 EamA-like transporter family; Region: EamA; pfam00892 1072459002547 outer membrane protein X; Provisional; Region: ompX; PRK09408 1072459002548 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 1072459002549 Sulfatase; Region: Sulfatase; pfam00884 1072459002550 manganese transport regulator MntR; Provisional; Region: PRK11050 1072459002551 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1072459002552 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1072459002553 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1072459002554 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 1072459002555 transmembrane helices; other site 1072459002556 L,D-transpeptidase; Provisional; Region: PRK10260 1072459002557 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1072459002558 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1072459002559 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1072459002560 Walker A/P-loop; other site 1072459002561 ATP binding site [chemical binding]; other site 1072459002562 Q-loop/lid; other site 1072459002563 ABC transporter signature motif; other site 1072459002564 Walker B; other site 1072459002565 D-loop; other site 1072459002566 H-loop/switch region; other site 1072459002567 ABC transporter; Region: ABC_tran_2; pfam12848 1072459002568 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1072459002569 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 1072459002570 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 1072459002571 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1072459002572 active site 1072459002573 motif I; other site 1072459002574 motif II; other site 1072459002575 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1072459002576 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 1072459002577 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 1072459002578 dimer interface [polypeptide binding]; other site 1072459002579 active site 1072459002580 glycine loop; other site 1072459002581 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 1072459002582 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1072459002583 active site 1072459002584 intersubunit interactions; other site 1072459002585 catalytic residue [active] 1072459002586 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 1072459002587 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1072459002588 ATP binding site [chemical binding]; other site 1072459002589 substrate interface [chemical binding]; other site 1072459002590 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 1072459002591 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1072459002592 dimer interface [polypeptide binding]; other site 1072459002593 putative functional site; other site 1072459002594 putative MPT binding site; other site 1072459002595 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 1072459002596 catalytic nucleophile [active] 1072459002597 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 1072459002598 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1072459002599 Walker A/P-loop; other site 1072459002600 ATP binding site [chemical binding]; other site 1072459002601 Q-loop/lid; other site 1072459002602 ABC transporter signature motif; other site 1072459002603 Walker B; other site 1072459002604 D-loop; other site 1072459002605 H-loop/switch region; other site 1072459002606 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1072459002607 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1072459002608 Walker A/P-loop; other site 1072459002609 ATP binding site [chemical binding]; other site 1072459002610 Q-loop/lid; other site 1072459002611 ABC transporter signature motif; other site 1072459002612 Walker B; other site 1072459002613 D-loop; other site 1072459002614 H-loop/switch region; other site 1072459002615 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1072459002616 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 1072459002617 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 1072459002618 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 1072459002619 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1072459002620 dimer interface [polypeptide binding]; other site 1072459002621 conserved gate region; other site 1072459002622 putative PBP binding loops; other site 1072459002623 ABC-ATPase subunit interface; other site 1072459002624 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 1072459002625 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1072459002626 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1072459002627 dimer interface [polypeptide binding]; other site 1072459002628 conserved gate region; other site 1072459002629 putative PBP binding loops; other site 1072459002630 ABC-ATPase subunit interface; other site 1072459002631 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1072459002632 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1072459002633 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1072459002634 metal binding site [ion binding]; metal-binding site 1072459002635 active site 1072459002636 I-site; other site 1072459002637 Predicted transcriptional regulator [Transcription]; Region: COG2944 1072459002638 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1072459002639 non-specific DNA binding site [nucleotide binding]; other site 1072459002640 salt bridge; other site 1072459002641 sequence-specific DNA binding site [nucleotide binding]; other site 1072459002642 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4737 1072459002643 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 1072459002644 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1072459002645 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1072459002646 FeS/SAM binding site; other site 1072459002647 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 1072459002648 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1072459002649 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1072459002650 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1072459002651 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 1072459002652 putative C-terminal domain interface [polypeptide binding]; other site 1072459002653 putative GSH binding site (G-site) [chemical binding]; other site 1072459002654 putative dimer interface [polypeptide binding]; other site 1072459002655 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1072459002656 N-terminal domain interface [polypeptide binding]; other site 1072459002657 dimer interface [polypeptide binding]; other site 1072459002658 substrate binding pocket (H-site) [chemical binding]; other site 1072459002659 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 1072459002660 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1072459002661 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1072459002662 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 1072459002663 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1072459002664 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1072459002665 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 1072459002666 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1072459002667 active site 1072459002668 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 1072459002669 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459002670 putative substrate translocation pore; other site 1072459002671 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1072459002672 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1072459002673 active site 1072459002674 motif I; other site 1072459002675 motif II; other site 1072459002676 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1072459002677 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1072459002678 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459002679 putative substrate translocation pore; other site 1072459002680 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1072459002681 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1072459002682 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1072459002683 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1072459002684 putative transporter; Provisional; Region: PRK04972 1072459002685 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1072459002686 TrkA-C domain; Region: TrkA_C; pfam02080 1072459002687 TrkA-C domain; Region: TrkA_C; pfam02080 1072459002688 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 1072459002689 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 1072459002690 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 1072459002691 GSH binding site [chemical binding]; other site 1072459002692 catalytic residues [active] 1072459002693 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 1072459002694 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1072459002695 dimer interface [polypeptide binding]; other site 1072459002696 FMN binding site [chemical binding]; other site 1072459002697 NADPH bind site [chemical binding]; other site 1072459002698 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 1072459002699 RimK-like ATP-grasp domain; Region: RimK; pfam08443 1072459002700 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1072459002701 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1072459002702 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1072459002703 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 1072459002704 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1072459002705 Walker A/P-loop; other site 1072459002706 ATP binding site [chemical binding]; other site 1072459002707 Q-loop/lid; other site 1072459002708 ABC transporter signature motif; other site 1072459002709 Walker B; other site 1072459002710 D-loop; other site 1072459002711 H-loop/switch region; other site 1072459002712 TOBE domain; Region: TOBE_2; pfam08402 1072459002713 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1072459002714 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1072459002715 dimer interface [polypeptide binding]; other site 1072459002716 conserved gate region; other site 1072459002717 putative PBP binding loops; other site 1072459002718 ABC-ATPase subunit interface; other site 1072459002719 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1072459002720 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1072459002721 dimer interface [polypeptide binding]; other site 1072459002722 conserved gate region; other site 1072459002723 putative PBP binding loops; other site 1072459002724 ABC-ATPase subunit interface; other site 1072459002725 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 1072459002726 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 1072459002727 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1072459002728 S-adenosylmethionine binding site [chemical binding]; other site 1072459002729 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 1072459002730 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1072459002731 substrate binding pocket [chemical binding]; other site 1072459002732 membrane-bound complex binding site; other site 1072459002733 hinge residues; other site 1072459002734 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1072459002735 dimer interface [polypeptide binding]; other site 1072459002736 conserved gate region; other site 1072459002737 putative PBP binding loops; other site 1072459002738 ABC-ATPase subunit interface; other site 1072459002739 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1072459002740 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1072459002741 dimer interface [polypeptide binding]; other site 1072459002742 conserved gate region; other site 1072459002743 putative PBP binding loops; other site 1072459002744 ABC-ATPase subunit interface; other site 1072459002745 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 1072459002746 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1072459002747 substrate binding pocket [chemical binding]; other site 1072459002748 membrane-bound complex binding site; other site 1072459002749 hinge residues; other site 1072459002750 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 1072459002751 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1072459002752 Walker A/P-loop; other site 1072459002753 ATP binding site [chemical binding]; other site 1072459002754 Q-loop/lid; other site 1072459002755 ABC transporter signature motif; other site 1072459002756 Walker B; other site 1072459002757 D-loop; other site 1072459002758 H-loop/switch region; other site 1072459002759 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1072459002760 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1072459002761 hypothetical protein; Provisional; Region: PRK02877 1072459002762 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1072459002763 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1072459002764 amidase catalytic site [active] 1072459002765 Zn binding residues [ion binding]; other site 1072459002766 substrate binding site [chemical binding]; other site 1072459002767 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1072459002768 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1072459002769 NAD(P) binding site [chemical binding]; other site 1072459002770 active site 1072459002771 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1072459002772 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 1072459002773 putative NAD(P) binding site [chemical binding]; other site 1072459002774 putative active site [active] 1072459002775 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 1072459002776 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1072459002777 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 1072459002778 tetramer interface [polypeptide binding]; other site 1072459002779 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1072459002780 catalytic residue [active] 1072459002781 pyruvate dehydrogenase; Provisional; Region: PRK09124 1072459002782 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1072459002783 PYR/PP interface [polypeptide binding]; other site 1072459002784 dimer interface [polypeptide binding]; other site 1072459002785 tetramer interface [polypeptide binding]; other site 1072459002786 TPP binding site [chemical binding]; other site 1072459002787 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1072459002788 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1072459002789 TPP-binding site [chemical binding]; other site 1072459002790 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 1072459002791 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 1072459002792 FAD binding pocket [chemical binding]; other site 1072459002793 FAD binding motif [chemical binding]; other site 1072459002794 phosphate binding motif [ion binding]; other site 1072459002795 beta-alpha-beta structure motif; other site 1072459002796 NAD binding pocket [chemical binding]; other site 1072459002797 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1072459002798 catalytic loop [active] 1072459002799 iron binding site [ion binding]; other site 1072459002800 hybrid cluster protein; Provisional; Region: PRK05290 1072459002801 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1072459002802 ACS interaction site; other site 1072459002803 CODH interaction site; other site 1072459002804 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 1072459002805 hybrid metal cluster; other site 1072459002806 Predicted membrane protein [Function unknown]; Region: COG2431 1072459002807 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1072459002808 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1072459002809 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1072459002810 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1072459002811 amphipathic channel; other site 1072459002812 Asn-Pro-Ala signature motifs; other site 1072459002813 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 1072459002814 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 1072459002815 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 1072459002816 putative active site [active] 1072459002817 putative metal-binding site [ion binding]; other site 1072459002818 Protein of unknown function (DUF535); Region: DUF535; pfam04393 1072459002819 macrolide transporter subunit MacA; Provisional; Region: PRK11578 1072459002820 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1072459002821 HlyD family secretion protein; Region: HlyD_3; pfam13437 1072459002822 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 1072459002823 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1072459002824 Walker A/P-loop; other site 1072459002825 ATP binding site [chemical binding]; other site 1072459002826 Q-loop/lid; other site 1072459002827 ABC transporter signature motif; other site 1072459002828 Walker B; other site 1072459002829 D-loop; other site 1072459002830 H-loop/switch region; other site 1072459002831 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1072459002832 FtsX-like permease family; Region: FtsX; pfam02687 1072459002833 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1072459002834 DNA-binding site [nucleotide binding]; DNA binding site 1072459002835 RNA-binding motif; other site 1072459002836 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1072459002837 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 1072459002838 Clp amino terminal domain; Region: Clp_N; pfam02861 1072459002839 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1072459002840 Walker A motif; other site 1072459002841 ATP binding site [chemical binding]; other site 1072459002842 Walker B motif; other site 1072459002843 arginine finger; other site 1072459002844 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1072459002845 Walker A motif; other site 1072459002846 ATP binding site [chemical binding]; other site 1072459002847 Walker B motif; other site 1072459002848 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1072459002849 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1072459002850 rRNA binding site [nucleotide binding]; other site 1072459002851 predicted 30S ribosome binding site; other site 1072459002852 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 1072459002853 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 1072459002854 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1072459002855 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 1072459002856 Walker A/P-loop; other site 1072459002857 ATP binding site [chemical binding]; other site 1072459002858 Q-loop/lid; other site 1072459002859 ABC transporter signature motif; other site 1072459002860 Walker B; other site 1072459002861 D-loop; other site 1072459002862 H-loop/switch region; other site 1072459002863 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 1072459002864 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1072459002865 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1072459002866 Walker A/P-loop; other site 1072459002867 ATP binding site [chemical binding]; other site 1072459002868 Q-loop/lid; other site 1072459002869 ABC transporter signature motif; other site 1072459002870 Walker B; other site 1072459002871 D-loop; other site 1072459002872 H-loop/switch region; other site 1072459002873 thioredoxin reductase; Provisional; Region: PRK10262 1072459002874 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1072459002875 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1072459002876 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 1072459002877 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1072459002878 putative DNA binding site [nucleotide binding]; other site 1072459002879 putative Zn2+ binding site [ion binding]; other site 1072459002880 AsnC family; Region: AsnC_trans_reg; pfam01037 1072459002881 DNA translocase FtsK; Provisional; Region: PRK10263 1072459002882 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1072459002883 DNA translocase FtsK; Provisional; Region: PRK10263 1072459002884 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1072459002885 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1072459002886 periplasmic chaperone LolA; Region: lolA; TIGR00547 1072459002887 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 1072459002888 recombination factor protein RarA; Reviewed; Region: PRK13342 1072459002889 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1072459002890 Walker A motif; other site 1072459002891 ATP binding site [chemical binding]; other site 1072459002892 Walker B motif; other site 1072459002893 arginine finger; other site 1072459002894 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1072459002895 seryl-tRNA synthetase; Provisional; Region: PRK05431 1072459002896 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1072459002897 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1072459002898 dimer interface [polypeptide binding]; other site 1072459002899 active site 1072459002900 motif 1; other site 1072459002901 motif 2; other site 1072459002902 motif 3; other site 1072459002903 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 1072459002904 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1072459002905 putative [Fe4-S4] binding site [ion binding]; other site 1072459002906 putative molybdopterin cofactor binding site [chemical binding]; other site 1072459002907 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1072459002908 putative molybdopterin cofactor binding site; other site 1072459002909 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1072459002910 4Fe-4S binding domain; Region: Fer4; pfam00037 1072459002911 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 1072459002912 Isochorismatase family; Region: Isochorismatase; pfam00857 1072459002913 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1072459002914 catalytic triad [active] 1072459002915 dimer interface [polypeptide binding]; other site 1072459002916 conserved cis-peptide bond; other site 1072459002917 putative MFS family transporter protein; Provisional; Region: PRK03633 1072459002918 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459002919 putative substrate translocation pore; other site 1072459002920 Amino acid permease; Region: AA_permease_2; pfam13520 1072459002921 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1072459002922 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1072459002923 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1072459002924 putative effector binding pocket; other site 1072459002925 putative dimerization interface [polypeptide binding]; other site 1072459002926 hypothetical protein; Provisional; Region: PRK09739 1072459002927 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1072459002928 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 1072459002929 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1072459002930 FeS/SAM binding site; other site 1072459002931 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1072459002932 Pyruvate formate lyase 1; Region: PFL1; cd01678 1072459002933 coenzyme A binding site [chemical binding]; other site 1072459002934 active site 1072459002935 catalytic residues [active] 1072459002936 glycine loop; other site 1072459002937 formate transporter; Provisional; Region: PRK10805 1072459002938 uncharacterized domain; Region: TIGR00702 1072459002939 YcaO-like family; Region: YcaO; pfam02624 1072459002940 Predicted membrane protein [Function unknown]; Region: COG2323 1072459002941 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1072459002942 homodimer interface [polypeptide binding]; other site 1072459002943 substrate-cofactor binding pocket; other site 1072459002944 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1072459002945 catalytic residue [active] 1072459002946 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1072459002947 Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554 1072459002948 hinge; other site 1072459002949 active site 1072459002950 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 1072459002951 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1072459002952 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1072459002953 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1072459002954 cytidylate kinase; Provisional; Region: cmk; PRK00023 1072459002955 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1072459002956 CMP-binding site; other site 1072459002957 The sites determining sugar specificity; other site 1072459002958 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1072459002959 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1072459002960 RNA binding site [nucleotide binding]; other site 1072459002961 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1072459002962 RNA binding site [nucleotide binding]; other site 1072459002963 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 1072459002964 RNA binding site [nucleotide binding]; other site 1072459002965 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 1072459002966 RNA binding site [nucleotide binding]; other site 1072459002967 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 1072459002968 RNA binding site [nucleotide binding]; other site 1072459002969 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1072459002970 IHF dimer interface [polypeptide binding]; other site 1072459002971 IHF - DNA interface [nucleotide binding]; other site 1072459002972 ComEC family competence protein; Provisional; Region: PRK11539 1072459002973 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1072459002974 ComEC/Rec2-related protein; Region: ComEC_N-term; TIGR00360 1072459002975 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1072459002976 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 1072459002977 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1072459002978 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1072459002979 Walker A/P-loop; other site 1072459002980 ATP binding site [chemical binding]; other site 1072459002981 Q-loop/lid; other site 1072459002982 ABC transporter signature motif; other site 1072459002983 Walker B; other site 1072459002984 D-loop; other site 1072459002985 H-loop/switch region; other site 1072459002986 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 1072459002987 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 1072459002988 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1072459002989 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1072459002990 hypothetical protein; Provisional; Region: PRK11827 1072459002991 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1072459002992 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1072459002993 Ligand binding site; other site 1072459002994 oligomer interface; other site 1072459002995 hypothetical protein; Provisional; Region: PRK10593 1072459002996 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1072459002997 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1072459002998 putative active site [active] 1072459002999 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1072459003000 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1072459003001 S-adenosylmethionine binding site [chemical binding]; other site 1072459003002 condesin subunit F; Provisional; Region: PRK05260 1072459003003 condesin subunit E; Provisional; Region: PRK05256 1072459003004 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 1072459003005 MukB N-terminal; Region: MukB; pfam04310 1072459003006 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 1072459003007 murein L,D-transpeptidase; Provisional; Region: PRK10594 1072459003008 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1072459003009 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1072459003010 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1072459003011 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 1072459003012 Peptidase M15; Region: Peptidase_M15_3; cl01194 1072459003013 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1072459003014 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1072459003015 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1072459003016 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1072459003017 homodimer interface [polypeptide binding]; other site 1072459003018 catalytic residue [active] 1072459003019 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1072459003020 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1072459003021 trimer interface [polypeptide binding]; other site 1072459003022 eyelet of channel; other site 1072459003023 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1072459003024 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 1072459003025 putative dimer interface [polypeptide binding]; other site 1072459003026 putative anticodon binding site; other site 1072459003027 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1072459003028 homodimer interface [polypeptide binding]; other site 1072459003029 motif 1; other site 1072459003030 motif 2; other site 1072459003031 active site 1072459003032 motif 3; other site 1072459003033 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 1072459003034 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 1072459003035 active site 1072459003036 aminopeptidase N; Provisional; Region: pepN; PRK14015 1072459003037 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 1072459003038 active site 1072459003039 Zn binding site [ion binding]; other site 1072459003040 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 1072459003041 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1072459003042 Walker A/P-loop; other site 1072459003043 ATP binding site [chemical binding]; other site 1072459003044 Q-loop/lid; other site 1072459003045 ABC transporter signature motif; other site 1072459003046 Walker B; other site 1072459003047 D-loop; other site 1072459003048 H-loop/switch region; other site 1072459003049 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1072459003050 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1072459003051 dimer interface [polypeptide binding]; other site 1072459003052 conserved gate region; other site 1072459003053 putative PBP binding loops; other site 1072459003054 ABC-ATPase subunit interface; other site 1072459003055 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1072459003056 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1072459003057 active site 1072459003058 dimer interface [polypeptide binding]; other site 1072459003059 non-prolyl cis peptide bond; other site 1072459003060 insertion regions; other site 1072459003061 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1072459003062 substrate binding pocket [chemical binding]; other site 1072459003063 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1072459003064 membrane-bound complex binding site; other site 1072459003065 hinge residues; other site 1072459003066 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 1072459003067 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1072459003068 Fimbrial protein; Region: Fimbrial; cl01416 1072459003069 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1072459003070 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1072459003071 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1072459003072 outer membrane usher protein; Provisional; Region: PRK15193 1072459003073 PapC N-terminal domain; Region: PapC_N; pfam13954 1072459003074 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1072459003075 PapC C-terminal domain; Region: PapC_C; pfam13953 1072459003076 Fimbrial protein; Region: Fimbrial; cl01416 1072459003077 Fimbrial protein; Region: Fimbrial; cl01416 1072459003078 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1072459003079 putativi pili assembly chaperone; Provisional; Region: PRK11385 1072459003080 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1072459003081 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1072459003082 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1072459003083 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1072459003084 quinone interaction residues [chemical binding]; other site 1072459003085 active site 1072459003086 catalytic residues [active] 1072459003087 FMN binding site [chemical binding]; other site 1072459003088 substrate binding site [chemical binding]; other site 1072459003089 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 1072459003090 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 1072459003091 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 1072459003092 MOSC domain; Region: MOSC; pfam03473 1072459003093 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1072459003094 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1072459003095 catalytic loop [active] 1072459003096 iron binding site [ion binding]; other site 1072459003097 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 1072459003098 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1072459003099 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 1072459003100 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1072459003101 S-adenosylmethionine binding site [chemical binding]; other site 1072459003102 ABC transporter ATPase component; Reviewed; Region: PRK11147 1072459003103 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1072459003104 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1072459003105 Walker A/P-loop; other site 1072459003106 Walker A/P-loop; other site 1072459003107 ATP binding site [chemical binding]; other site 1072459003108 ATP binding site [chemical binding]; other site 1072459003109 Q-loop/lid; other site 1072459003110 Q-loop/lid; other site 1072459003111 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1072459003112 ABC transporter signature motif; other site 1072459003113 Walker B; other site 1072459003114 D-loop; other site 1072459003115 ABC transporter; Region: ABC_tran_2; pfam12848 1072459003116 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1072459003117 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 1072459003118 Paraquat-inducible protein A; Region: PqiA; pfam04403 1072459003119 Paraquat-inducible protein A; Region: PqiA; pfam04403 1072459003120 paraquat-inducible protein B; Provisional; Region: PRK10807 1072459003121 mce related protein; Region: MCE; pfam02470 1072459003122 mce related protein; Region: MCE; pfam02470 1072459003123 mce related protein; Region: MCE; pfam02470 1072459003124 DASH complex subunit Duo1; Region: DASH_Duo1; pfam08651 1072459003125 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 1072459003126 Protein of unknown function (DUF330); Region: DUF330; pfam03886 1072459003127 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 1072459003128 active site 1 [active] 1072459003129 dimer interface [polypeptide binding]; other site 1072459003130 active site 2 [active] 1072459003131 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 1072459003132 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1072459003133 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 1072459003134 outer membrane protein A; Reviewed; Region: PRK10808 1072459003135 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 1072459003136 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1072459003137 ligand binding site [chemical binding]; other site 1072459003138 cell division inhibitor SulA; Region: sula; TIGR00623 1072459003139 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 1072459003140 TfoX C-terminal domain; Region: TfoX_C; pfam04994 1072459003141 TIGR01666 family membrane protein; Region: YCCS 1072459003142 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1072459003143 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1072459003144 Predicted membrane protein [Function unknown]; Region: COG3304 1072459003145 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1072459003146 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1072459003147 DNA helicase IV; Provisional; Region: helD; PRK11054 1072459003148 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 1072459003149 Part of AAA domain; Region: AAA_19; pfam13245 1072459003150 Family description; Region: UvrD_C_2; pfam13538 1072459003151 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1072459003152 active site 1072459003153 dimer interfaces [polypeptide binding]; other site 1072459003154 catalytic residues [active] 1072459003155 hypothetical protein; Provisional; Region: PRK03641 1072459003156 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110 1072459003157 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1072459003158 heat shock protein HspQ; Provisional; Region: PRK14129 1072459003159 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 1072459003160 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 1072459003161 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1072459003162 putative RNA binding site [nucleotide binding]; other site 1072459003163 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1072459003164 S-adenosylmethionine binding site [chemical binding]; other site 1072459003165 Acylphosphatase; Region: Acylphosphatase; cl00551 1072459003166 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 1072459003167 sulfur transfer protein TusE; Provisional; Region: PRK11508 1072459003168 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1072459003169 YccA-like proteins; Region: YccA_like; cd10433 1072459003170 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 1072459003171 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 1072459003172 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 1072459003173 hydrogenase 1 large subunit; Provisional; Region: PRK10170 1072459003174 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 1072459003175 hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171 1072459003176 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 1072459003177 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 1072459003178 putative substrate-binding site; other site 1072459003179 nickel binding site [ion binding]; other site 1072459003180 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 1072459003181 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 1072459003182 cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035 1072459003183 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1072459003184 cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028 1072459003185 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1072459003186 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 1072459003187 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1072459003188 catalytic core [active] 1072459003189 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1072459003190 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1072459003191 DNA-binding site [nucleotide binding]; DNA binding site 1072459003192 RNA-binding motif; other site 1072459003193 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1072459003194 DNA-binding site [nucleotide binding]; DNA binding site 1072459003195 RNA-binding motif; other site 1072459003196 GnsA/GnsB family; Region: GnsAB; pfam08178 1072459003197 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 1072459003198 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1072459003199 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1072459003200 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1072459003201 hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466 1072459003202 HAMP domain; Region: HAMP; pfam00672 1072459003203 dimerization interface [polypeptide binding]; other site 1072459003204 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1072459003205 dimer interface [polypeptide binding]; other site 1072459003206 phosphorylation site [posttranslational modification] 1072459003207 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1072459003208 ATP binding site [chemical binding]; other site 1072459003209 Mg2+ binding site [ion binding]; other site 1072459003210 G-X-G motif; other site 1072459003211 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1072459003212 active site 1072459003213 phosphorylation site [posttranslational modification] 1072459003214 intermolecular recognition site; other site 1072459003215 dimerization interface [polypeptide binding]; other site 1072459003216 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1072459003217 putative binding surface; other site 1072459003218 active site 1072459003219 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 1072459003220 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1072459003221 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; pfam02899 1072459003222 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 1072459003223 dimer interface [polypeptide binding]; other site 1072459003224 active site 1072459003225 Int/Topo IB signature motif; other site 1072459003226 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 1072459003227 Protein of unknown function (DUF550); Region: DUF550; pfam04447 1072459003228 Protein of unknown function (DUF551); Region: DUF551; pfam04448 1072459003229 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 1072459003230 Protein of unknown function (DUF2737); Region: DUF2737; pfam10930 1072459003231 Protein of unknown function (DUF2856); Region: DUF2856; pfam11043 1072459003232 AAA domain; Region: AAA_22; pfam13401 1072459003233 RNA helicase; Region: RNA_helicase; pfam00910 1072459003234 Bacteriophage lambda Kil protein; Region: Lambda_Kil; pfam06301 1072459003235 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1072459003236 non-specific DNA binding site [nucleotide binding]; other site 1072459003237 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1072459003238 salt bridge; other site 1072459003239 sequence-specific DNA binding site [nucleotide binding]; other site 1072459003240 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1072459003241 Catalytic site [active] 1072459003242 Cro; Region: Cro; pfam09048 1072459003243 Bacteriophage CII protein; Region: Phage_CII; pfam05269 1072459003244 Helix-turn-helix domain; Region: HTH_36; pfam13730 1072459003245 helix_turn_helix, Arsenical Resistance Operon Repressor; Region: HTH_ARSR; smart00418 1072459003246 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 1072459003247 active site 1072459003248 metal binding site [ion binding]; metal-binding site 1072459003249 interdomain interaction site; other site 1072459003250 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1072459003251 Walker A motif; other site 1072459003252 ATP binding site [chemical binding]; other site 1072459003253 AAA domain; Region: AAA_25; pfam13481 1072459003254 Walker B motif; other site 1072459003255 NinB protein; Region: NinB; pfam05772 1072459003256 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 1072459003257 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 1072459003258 Protein of unknown function (DUF1364); Region: DUF1364; pfam07102 1072459003259 Endodeoxyribonuclease RusA; Region: RusA; cl01885 1072459003260 Lysis protein S; Region: Lysis_S; pfam04971 1072459003261 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 1072459003262 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1072459003263 catalytic residues [active] 1072459003264 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 1072459003265 YfbU domain; Region: YfbU; cl01137 1072459003266 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1072459003267 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1072459003268 active site 1072459003269 Phage terminase, small subunit; Region: Terminase_4; pfam05119 1072459003270 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 1072459003271 Phage portal protein; Region: Phage_portal; pfam04860 1072459003272 Phage-related protein [Function unknown]; Region: COG4695 1072459003273 Phage head maturation protease [General function prediction only]; Region: COG3740 1072459003274 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1072459003275 Phage capsid family; Region: Phage_capsid; pfam05065 1072459003276 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 1072459003277 oligomerization interface [polypeptide binding]; other site 1072459003278 Bacteriophage head-tail adaptor [General function prediction only]; Region: COG5614 1072459003279 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 1072459003280 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 1072459003281 Immunoglobulin domain; Region: Ig; cl11960 1072459003282 Phage tail assembly chaperone; Region: Phage_TAC; pfam06222 1072459003283 Protein of unknown function (DUF4035); Region: DUF4035; pfam13227 1072459003284 Phage-related minor tail protein [Function unknown]; Region: COG5281 1072459003285 tape measure domain; Region: tape_meas_nterm; TIGR02675 1072459003286 Tail length tape measure protein; Region: Phage_HK97_TLTM; pfam06120 1072459003287 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 1072459003288 Phage minor tail protein; Region: Phage_min_tail; pfam05939 1072459003289 Phage-related protein [Function unknown]; Region: gp18; COG4672 1072459003290 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 1072459003291 MPN+ (JAMM) motif; other site 1072459003292 Zinc-binding site [ion binding]; other site 1072459003293 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1072459003294 NlpC/P60 family; Region: NLPC_P60; cl17555 1072459003295 Phage-related protein, tail component [Function unknown]; Region: COG4723 1072459003296 Phage-related protein, tail component [Function unknown]; Region: COG4733 1072459003297 Putative phage tail protein; Region: Phage-tail_3; pfam13550 1072459003298 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1072459003299 Interdomain contacts; other site 1072459003300 Cytokine receptor motif; other site 1072459003301 Archaeal/vacuolar-type H+-ATPase subunit H [Energy production and conversion]; Region: NtpF; COG2811 1072459003302 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 1072459003303 Fibronectin type III protein; Region: DUF3672; pfam12421 1072459003304 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 1072459003305 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 1072459003306 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 1072459003307 TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306 1072459003308 putative ligand binding site [chemical binding]; other site 1072459003309 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 1072459003310 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1072459003311 active site 1072459003312 phosphorylation site [posttranslational modification] 1072459003313 intermolecular recognition site; other site 1072459003314 dimerization interface [polypeptide binding]; other site 1072459003315 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1072459003316 DNA binding site [nucleotide binding] 1072459003317 trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032 1072459003318 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 1072459003319 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 1072459003320 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1072459003321 molybdopterin cofactor binding site [chemical binding]; other site 1072459003322 substrate binding site [chemical binding]; other site 1072459003323 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 1072459003324 molybdopterin cofactor binding site; other site 1072459003325 chaperone protein TorD; Validated; Region: torD; PRK04976 1072459003326 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 1072459003327 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 1072459003328 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 1072459003329 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1072459003330 HSP70 interaction site [polypeptide binding]; other site 1072459003331 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1072459003332 substrate binding site [polypeptide binding]; other site 1072459003333 dimer interface [polypeptide binding]; other site 1072459003334 hypothetical protein; Provisional; Region: PRK09784 1072459003335 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 1072459003336 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1072459003337 catalytic core [active] 1072459003338 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1072459003339 hypothetical protein; Provisional; Region: PRK10174 1072459003340 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 1072459003341 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1072459003342 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 1072459003343 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 1072459003344 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 1072459003345 putative FMN binding site [chemical binding]; other site 1072459003346 pyrimidine utilization protein D; Region: RutD; TIGR03611 1072459003347 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1072459003348 homotrimer interaction site [polypeptide binding]; other site 1072459003349 putative active site [active] 1072459003350 Isochorismatase family; Region: Isochorismatase; pfam00857 1072459003351 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1072459003352 catalytic triad [active] 1072459003353 conserved cis-peptide bond; other site 1072459003354 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1072459003355 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1072459003356 active site 1072459003357 dimer interface [polypeptide binding]; other site 1072459003358 non-prolyl cis peptide bond; other site 1072459003359 insertion regions; other site 1072459003360 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 1072459003361 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1072459003362 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 1072459003363 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 1072459003364 Predicted transcriptional regulator [Transcription]; Region: COG3905 1072459003365 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 1072459003366 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 1072459003367 Glutamate binding site [chemical binding]; other site 1072459003368 NAD binding site [chemical binding]; other site 1072459003369 catalytic residues [active] 1072459003370 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1072459003371 Na binding site [ion binding]; other site 1072459003372 FTR1 family protein; Region: TIGR00145 1072459003373 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 1072459003374 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 1072459003375 Imelysin; Region: Peptidase_M75; pfam09375 1072459003376 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 1072459003377 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 1072459003378 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1072459003379 hypothetical protein; Provisional; Region: PRK10536 1072459003380 putative PGA biosynthesis protein; Provisional; Region: pgaD; PRK14585 1072459003381 N-glycosyltransferase; Provisional; Region: PRK11204 1072459003382 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1072459003383 DXD motif; other site 1072459003384 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 1072459003385 outer membrane N-deacetylase; Provisional; Region: pgaB; PRK14582 1072459003386 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 1072459003387 putative active site [active] 1072459003388 putative metal binding site [ion binding]; other site 1072459003389 outer membrane protein PgaA; Provisional; Region: pgaA; PRK10049 1072459003390 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1072459003391 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1072459003392 metal binding site [ion binding]; metal-binding site 1072459003393 active site 1072459003394 I-site; other site 1072459003395 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 1072459003396 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 1072459003397 putative ligand binding site [chemical binding]; other site 1072459003398 NAD binding site [chemical binding]; other site 1072459003399 dimerization interface [polypeptide binding]; other site 1072459003400 catalytic site [active] 1072459003401 putative hydrolase; Validated; Region: PRK09248 1072459003402 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 1072459003403 active site 1072459003404 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 1072459003405 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 1072459003406 curli production assembly/transport protein CsgG; Provisional; Region: PRK15184 1072459003407 curli assembly protein CsgF; Provisional; Region: PRK10050 1072459003408 curli assembly protein CsgE; Provisional; Region: PRK10386 1072459003409 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 1072459003410 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1072459003411 DNA binding residues [nucleotide binding] 1072459003412 dimerization interface [polypeptide binding]; other site 1072459003413 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 1072459003414 Curlin associated repeat; Region: Curlin_rpt; pfam07012 1072459003415 Curlin associated repeat; Region: Curlin_rpt; pfam07012 1072459003416 major curlin subunit; Provisional; Region: csgA; PRK10051 1072459003417 Curlin associated repeat; Region: Curlin_rpt; pfam07012 1072459003418 Curlin associated repeat; Region: Curlin_rpt; pfam07012 1072459003419 curli assembly protein CsgC; Provisional; Region: csgC; PRK10102 1072459003420 Fimbrial protein; Region: Fimbrial; cl01416 1072459003421 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 1072459003422 putative ADP-ribose binding site [chemical binding]; other site 1072459003423 putative active site [active] 1072459003424 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 1072459003425 PLD-like domain; Region: PLDc_2; pfam13091 1072459003426 putative active site [active] 1072459003427 catalytic site [active] 1072459003428 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 1072459003429 PLD-like domain; Region: PLDc_2; pfam13091 1072459003430 putative active site [active] 1072459003431 catalytic site [active] 1072459003432 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 1072459003433 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1072459003434 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 1072459003435 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349 1072459003436 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1072459003437 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 1072459003438 Ligand binding site; other site 1072459003439 DXD motif; other site 1072459003440 lipoprotein; Provisional; Region: PRK10175 1072459003441 secY/secA suppressor protein; Provisional; Region: PRK11467 1072459003442 drug efflux system protein MdtG; Provisional; Region: PRK09874 1072459003443 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459003444 putative substrate translocation pore; other site 1072459003445 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1072459003446 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1072459003447 putative acyl-acceptor binding pocket; other site 1072459003448 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1072459003449 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1072459003450 active site residue [active] 1072459003451 hypothetical protein; Provisional; Region: PRK03757 1072459003452 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1072459003453 Protein of unknown function (DUF2770); Region: DUF2770; pfam10968 1072459003454 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 1072459003455 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1072459003456 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 1072459003457 DNA damage-inducible protein I; Provisional; Region: PRK10597 1072459003458 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 1072459003459 active site 1072459003460 substrate binding pocket [chemical binding]; other site 1072459003461 dimer interface [polypeptide binding]; other site 1072459003462 lipoprotein; Provisional; Region: PRK10598 1072459003463 glutaredoxin 2; Provisional; Region: PRK10387 1072459003464 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 1072459003465 C-terminal domain interface [polypeptide binding]; other site 1072459003466 GSH binding site (G-site) [chemical binding]; other site 1072459003467 catalytic residues [active] 1072459003468 putative dimer interface [polypeptide binding]; other site 1072459003469 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 1072459003470 N-terminal domain interface [polypeptide binding]; other site 1072459003471 multidrug resistance protein MdtH; Provisional; Region: PRK11646 1072459003472 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459003473 putative substrate translocation pore; other site 1072459003474 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 1072459003475 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1072459003476 hypothetical protein; Provisional; Region: PRK11239 1072459003477 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 1072459003478 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1072459003479 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1072459003480 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1072459003481 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1072459003482 MviN-like protein; Region: MVIN; pfam03023 1072459003483 flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459 1072459003484 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 1072459003485 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 1072459003486 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1072459003487 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 1072459003488 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 1072459003489 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1072459003490 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1072459003491 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1072459003492 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1072459003493 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 1072459003494 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1072459003495 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1072459003496 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 1072459003497 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1072459003498 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1072459003499 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1072459003500 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787 1072459003501 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1072459003502 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 1072459003503 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 1072459003504 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1072459003505 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1072459003506 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 1072459003507 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 1072459003508 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 1072459003509 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 1072459003510 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 1072459003511 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 1072459003512 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1072459003513 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 1072459003514 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1072459003515 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 1072459003516 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 1072459003517 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1072459003518 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1072459003519 Coenzyme A binding pocket [chemical binding]; other site 1072459003520 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 1072459003521 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1072459003522 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1072459003523 homodimer interface [polypeptide binding]; other site 1072459003524 oligonucleotide binding site [chemical binding]; other site 1072459003525 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 1072459003526 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 1072459003527 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1072459003528 RNA binding surface [nucleotide binding]; other site 1072459003529 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1072459003530 active site 1072459003531 Maf-like protein; Region: Maf; pfam02545 1072459003532 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1072459003533 active site 1072459003534 dimer interface [polypeptide binding]; other site 1072459003535 hypothetical protein; Provisional; Region: PRK11193 1072459003536 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1072459003537 putative phosphate acyltransferase; Provisional; Region: PRK05331 1072459003538 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1072459003539 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1072459003540 dimer interface [polypeptide binding]; other site 1072459003541 active site 1072459003542 CoA binding pocket [chemical binding]; other site 1072459003543 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1072459003544 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1072459003545 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1072459003546 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1072459003547 NAD(P) binding site [chemical binding]; other site 1072459003548 homotetramer interface [polypeptide binding]; other site 1072459003549 homodimer interface [polypeptide binding]; other site 1072459003550 active site 1072459003551 acyl carrier protein; Provisional; Region: acpP; PRK00982 1072459003552 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 1072459003553 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1072459003554 dimer interface [polypeptide binding]; other site 1072459003555 active site 1072459003556 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1072459003557 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1072459003558 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1072459003559 catalytic residue [active] 1072459003560 conserved hypothetical protein, YceG family; Region: TIGR00247 1072459003561 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1072459003562 dimerization interface [polypeptide binding]; other site 1072459003563 thymidylate kinase; Validated; Region: tmk; PRK00698 1072459003564 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1072459003565 TMP-binding site; other site 1072459003566 ATP-binding site [chemical binding]; other site 1072459003567 DNA polymerase III subunit delta'; Validated; Region: PRK07993 1072459003568 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 1072459003569 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1072459003570 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1072459003571 active site 1072459003572 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 1072459003573 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1072459003574 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1072459003575 active site turn [active] 1072459003576 phosphorylation site [posttranslational modification] 1072459003577 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1072459003578 N-terminal plug; other site 1072459003579 ligand-binding site [chemical binding]; other site 1072459003580 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1072459003581 nucleotide binding site/active site [active] 1072459003582 HIT family signature motif; other site 1072459003583 catalytic residue [active] 1072459003584 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 1072459003585 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 1072459003586 putative dimer interface [polypeptide binding]; other site 1072459003587 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 1072459003588 thiamine kinase; Region: ycfN_thiK; TIGR02721 1072459003589 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1072459003590 active site 1072459003591 substrate binding site [chemical binding]; other site 1072459003592 ATP binding site [chemical binding]; other site 1072459003593 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1072459003594 beta-hexosaminidase; Provisional; Region: PRK05337 1072459003595 hypothetical protein; Provisional; Region: PRK04940 1072459003596 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1072459003597 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1072459003598 hypothetical protein; Provisional; Region: PRK11280 1072459003599 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1072459003600 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1072459003601 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1072459003602 L,D-transpeptidase; Provisional; Region: PRK10260 1072459003603 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1072459003604 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1072459003605 transcription-repair coupling factor; Provisional; Region: PRK10689 1072459003606 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1072459003607 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1072459003608 ATP binding site [chemical binding]; other site 1072459003609 putative Mg++ binding site [ion binding]; other site 1072459003610 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1072459003611 nucleotide binding region [chemical binding]; other site 1072459003612 ATP-binding site [chemical binding]; other site 1072459003613 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1072459003614 Predicted membrane protein [Function unknown]; Region: COG4763 1072459003615 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1072459003616 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 1072459003617 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1072459003618 FtsX-like permease family; Region: FtsX; pfam02687 1072459003619 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 1072459003620 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1072459003621 Walker A/P-loop; other site 1072459003622 ATP binding site [chemical binding]; other site 1072459003623 Q-loop/lid; other site 1072459003624 ABC transporter signature motif; other site 1072459003625 Walker B; other site 1072459003626 D-loop; other site 1072459003627 H-loop/switch region; other site 1072459003628 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 1072459003629 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1072459003630 FtsX-like permease family; Region: FtsX; pfam02687 1072459003631 fructokinase; Reviewed; Region: PRK09557 1072459003632 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1072459003633 nucleotide binding site [chemical binding]; other site 1072459003634 NAD-dependent deacetylase; Provisional; Region: PRK00481 1072459003635 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1072459003636 NAD+ binding site [chemical binding]; other site 1072459003637 substrate binding site [chemical binding]; other site 1072459003638 Zn binding site [ion binding]; other site 1072459003639 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1072459003640 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 1072459003641 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 1072459003642 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1072459003643 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1072459003644 dimer interface [polypeptide binding]; other site 1072459003645 conserved gate region; other site 1072459003646 putative PBP binding loops; other site 1072459003647 ABC-ATPase subunit interface; other site 1072459003648 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1072459003649 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1072459003650 dimer interface [polypeptide binding]; other site 1072459003651 conserved gate region; other site 1072459003652 putative PBP binding loops; other site 1072459003653 ABC-ATPase subunit interface; other site 1072459003654 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 1072459003655 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1072459003656 Walker A/P-loop; other site 1072459003657 ATP binding site [chemical binding]; other site 1072459003658 Q-loop/lid; other site 1072459003659 ABC transporter signature motif; other site 1072459003660 Walker B; other site 1072459003661 D-loop; other site 1072459003662 H-loop/switch region; other site 1072459003663 TOBE domain; Region: TOBE_2; pfam08402 1072459003664 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 1072459003665 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1072459003666 metal binding site [ion binding]; metal-binding site 1072459003667 dimer interface [polypeptide binding]; other site 1072459003668 Uncharacterized conserved protein [Function unknown]; Region: COG2850 1072459003669 Cupin-like domain; Region: Cupin_8; pfam13621 1072459003670 integrase; Provisional; Region: PRK09692 1072459003671 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1072459003672 active site 1072459003673 Int/Topo IB signature motif; other site 1072459003674 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 1072459003675 D5 N terminal like; Region: D5_N; smart00885 1072459003676 Phage associated DNA primase [General function prediction only]; Region: COG3378 1072459003677 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 1072459003678 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1072459003679 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1072459003680 ssDNA binding site [nucleotide binding]; other site 1072459003681 dimer interface [polypeptide binding]; other site 1072459003682 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1072459003683 Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653 1072459003684 Phage capsid family; Region: Phage_capsid; pfam05065 1072459003685 Phage head maturation protease [General function prediction only]; Region: COG3740 1072459003686 Phage-related protein [Function unknown]; Region: COG4695 1072459003687 Phage portal protein; Region: Phage_portal; pfam04860 1072459003688 Bacteriophage head-tail adaptor [General function prediction only]; Region: COG5614 1072459003689 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 1072459003690 oligomerization interface [polypeptide binding]; other site 1072459003691 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1072459003692 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1072459003693 active site 1072459003694 Phage terminase, small subunit; Region: Terminase_4; cl01525 1072459003695 Phage Terminase; Region: Terminase_1; pfam03354 1072459003696 sensor protein PhoQ; Provisional; Region: PRK10815 1072459003697 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 1072459003698 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1072459003699 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 1072459003700 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1072459003701 ATP binding site [chemical binding]; other site 1072459003702 Mg2+ binding site [ion binding]; other site 1072459003703 G-X-G motif; other site 1072459003704 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 1072459003705 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1072459003706 active site 1072459003707 phosphorylation site [posttranslational modification] 1072459003708 intermolecular recognition site; other site 1072459003709 dimerization interface [polypeptide binding]; other site 1072459003710 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1072459003711 DNA binding site [nucleotide binding] 1072459003712 adenylosuccinate lyase; Provisional; Region: PRK09285 1072459003713 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 1072459003714 tetramer interface [polypeptide binding]; other site 1072459003715 active site 1072459003716 putative lysogenization regulator; Reviewed; Region: PRK00218 1072459003717 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1072459003718 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 1072459003719 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 1072459003720 nudix motif; other site 1072459003721 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 1072459003722 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 1072459003723 probable active site [active] 1072459003724 isocitrate dehydrogenase; Validated; Region: PRK07362 1072459003725 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1072459003726 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 1072459003727 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1072459003728 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 1072459003729 dimer interface [polypeptide binding]; other site 1072459003730 active site 1072459003731 Int/Topo IB signature motif; other site 1072459003732 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 1072459003733 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 1072459003734 phage recombination protein Bet; Region: bet_lambda; TIGR01913 1072459003735 Host-nuclease inhibitor protein Gam; Region: Gam; pfam06064 1072459003736 Bacteriophage lambda Kil protein; Region: Lambda_Kil; pfam06301 1072459003737 Protein of unknown function (DUF2528); Region: DUF2528; pfam10800 1072459003738 putative transposase OrfB; Reviewed; Region: PHA02517 1072459003739 HTH-like domain; Region: HTH_21; pfam13276 1072459003740 Integrase core domain; Region: rve; pfam00665 1072459003741 Integrase core domain; Region: rve_3; pfam13683 1072459003742 Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471 1072459003743 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 1072459003744 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1072459003745 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1072459003746 catalytic residues [active] 1072459003747 catalytic nucleophile [active] 1072459003748 Presynaptic Site I dimer interface [polypeptide binding]; other site 1072459003749 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1072459003750 Synaptic Flat tetramer interface [polypeptide binding]; other site 1072459003751 Synaptic Site I dimer interface [polypeptide binding]; other site 1072459003752 DNA binding site [nucleotide binding] 1072459003753 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1072459003754 DNA-binding interface [nucleotide binding]; DNA binding site 1072459003755 Phage Tail Collar Domain; Region: Collar; pfam07484 1072459003756 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1072459003757 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; pfam09684 1072459003758 Baseplate J-like protein; Region: Baseplate_J; cl01294 1072459003759 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 1072459003760 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 1072459003761 Phage protein D [General function prediction only]; Region: COG3500 1072459003762 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 1072459003763 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 1072459003764 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 1072459003765 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 1072459003766 Phage tail tube protein FII; Region: Phage_tube; cl01390 1072459003767 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 1072459003768 Gp37 protein; Region: Gp37; pfam09646 1072459003769 Protein of unknown function (DUF1320); Region: DUF1320; pfam07030 1072459003770 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 1072459003771 Phage Mu protein F like protein; Region: Phage_Mu_F; pfam04233 1072459003772 Protein of unknown function (DUF935); Region: DUF935; pfam06074 1072459003773 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 1072459003774 Protein of unknown function (DUF3486); Region: DUF3486; pfam11985 1072459003775 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06476 1072459003776 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048 1072459003777 phage lambda Rz-like lysis protein; Region: PHA00276 1072459003778 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 1072459003779 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1072459003780 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1072459003781 catalytic residue [active] 1072459003782 Protein of unknown function (DUF4063); Region: DUF4063; pfam13272 1072459003783 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1072459003784 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 1072459003785 phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111 1072459003786 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1072459003787 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cl00198 1072459003788 Integrase core domain; Region: rve; pfam00665 1072459003789 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 1072459003790 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1072459003791 Walker A/P-loop; other site 1072459003792 ATP binding site [chemical binding]; other site 1072459003793 Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; cl01825 1072459003794 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u2; cd11539 1072459003795 metal binding site [ion binding]; metal-binding site 1072459003796 HTH-like domain; Region: HTH_21; pfam13276 1072459003797 Integrase core domain; Region: rve; pfam00665 1072459003798 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1072459003799 Integrase core domain; Region: rve_3; pfam13683 1072459003800 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1072459003801 Transposase; Region: HTH_Tnp_1; cl17663 1072459003802 Protein of unknown function (DUF1018); Region: DUF1018; pfam06252 1072459003803 Mor transcription activator family; Region: Mor; pfam08765 1072459003804 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 1072459003805 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 1072459003806 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1072459003807 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1072459003808 ABC-ATPase subunit interface; other site 1072459003809 dimer interface [polypeptide binding]; other site 1072459003810 putative PBP binding regions; other site 1072459003811 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1072459003812 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1072459003813 ABC-ATPase subunit interface; other site 1072459003814 dimer interface [polypeptide binding]; other site 1072459003815 putative PBP binding regions; other site 1072459003816 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 1072459003817 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1072459003818 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1072459003819 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1072459003820 metal binding site [ion binding]; metal-binding site 1072459003821 Protein of unknown function (DUF1398); Region: DUF1398; pfam07166 1072459003822 transcriptional regulator MirA; Provisional; Region: PRK15043 1072459003823 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 1072459003824 DNA binding residues [nucleotide binding] 1072459003825 putative transposase OrfB; Reviewed; Region: PHA02517 1072459003826 HTH-like domain; Region: HTH_21; pfam13276 1072459003827 Integrase core domain; Region: rve; pfam00665 1072459003828 Integrase core domain; Region: rve_3; pfam13683 1072459003829 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 1072459003830 putative transposase OrfB; Reviewed; Region: PHA02517 1072459003831 HTH-like domain; Region: HTH_21; pfam13276 1072459003832 Integrase core domain; Region: rve; pfam00665 1072459003833 Integrase core domain; Region: rve_3; pfam13683 1072459003834 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1072459003835 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1072459003836 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 1072459003837 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1072459003838 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1072459003839 Autotransporter beta-domain; Region: Autotransporter; smart00869 1072459003840 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 1072459003841 cell division inhibitor MinD; Provisional; Region: PRK10818 1072459003842 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1072459003843 Switch I; other site 1072459003844 Switch II; other site 1072459003845 septum formation inhibitor; Reviewed; Region: minC; PRK03511 1072459003846 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 1072459003847 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1072459003848 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 1072459003849 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 1072459003850 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 1072459003851 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1072459003852 hypothetical protein; Provisional; Region: PRK10691 1072459003853 hypothetical protein; Provisional; Region: PRK05170 1072459003854 Haemolysin E (HlyE); Region: HlyE; cl11627 1072459003855 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1072459003856 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1072459003857 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 1072459003858 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1072459003859 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1072459003860 Catalytic site [active] 1072459003861 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 1072459003862 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1072459003863 active site 1072459003864 DNA binding site [nucleotide binding] 1072459003865 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1072459003866 disulfide bond formation protein B; Provisional; Region: PRK01749 1072459003867 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1072459003868 transmembrane helices; other site 1072459003869 fatty acid metabolism regulator; Provisional; Region: PRK04984 1072459003870 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1072459003871 DNA-binding site [nucleotide binding]; DNA binding site 1072459003872 FadR C-terminal domain; Region: FadR_C; pfam07840 1072459003873 SpoVR family protein; Provisional; Region: PRK11767 1072459003874 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1072459003875 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1072459003876 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1072459003877 alanine racemase; Reviewed; Region: dadX; PRK03646 1072459003878 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1072459003879 active site 1072459003880 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1072459003881 substrate binding site [chemical binding]; other site 1072459003882 catalytic residues [active] 1072459003883 dimer interface [polypeptide binding]; other site 1072459003884 putative transposase OrfB; Reviewed; Region: PHA02517 1072459003885 HTH-like domain; Region: HTH_21; pfam13276 1072459003886 Integrase core domain; Region: rve; pfam00665 1072459003887 Integrase core domain; Region: rve_3; pfam13683 1072459003888 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 1072459003889 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1072459003890 TrkA-C domain; Region: TrkA_C; pfam02080 1072459003891 Transporter associated domain; Region: CorC_HlyC; smart01091 1072459003892 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1072459003893 dimer interface [polypeptide binding]; other site 1072459003894 catalytic triad [active] 1072459003895 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 1072459003896 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1072459003897 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1072459003898 catalytic residue [active] 1072459003899 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 1072459003900 Flagellar regulator YcgR; Region: YcgR; pfam07317 1072459003901 PilZ domain; Region: PilZ; pfam07238 1072459003902 hypothetical protein; Provisional; Region: PRK10457 1072459003903 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1072459003904 N-terminal plug; other site 1072459003905 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 1072459003906 ligand-binding site [chemical binding]; other site 1072459003907 molybdenum transport protein ModD; Provisional; Region: PRK06096 1072459003908 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 1072459003909 dimerization interface [polypeptide binding]; other site 1072459003910 active site 1072459003911 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1072459003912 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1072459003913 S-adenosylmethionine binding site [chemical binding]; other site 1072459003914 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1072459003915 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1072459003916 Walker A/P-loop; other site 1072459003917 ATP binding site [chemical binding]; other site 1072459003918 Q-loop/lid; other site 1072459003919 ABC transporter signature motif; other site 1072459003920 Walker B; other site 1072459003921 D-loop; other site 1072459003922 H-loop/switch region; other site 1072459003923 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1072459003924 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1072459003925 ABC-ATPase subunit interface; other site 1072459003926 dimer interface [polypeptide binding]; other site 1072459003927 putative PBP binding regions; other site 1072459003928 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1072459003929 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 1072459003930 putative metal binding site [ion binding]; other site 1072459003931 trehalase; Provisional; Region: treA; PRK13271 1072459003932 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 1072459003933 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 1072459003934 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3412 1072459003935 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1072459003936 dimerization domain swap beta strand [polypeptide binding]; other site 1072459003937 regulatory protein interface [polypeptide binding]; other site 1072459003938 active site 1072459003939 regulatory phosphorylation site [posttranslational modification]; other site 1072459003940 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1072459003941 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1072459003942 dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005 1072459003943 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 1072459003944 Dak1 domain; Region: Dak1; pfam02733 1072459003945 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 1072459003946 PAS domain; Region: PAS; smart00091 1072459003947 putative active site [active] 1072459003948 heme pocket [chemical binding]; other site 1072459003949 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1072459003950 Walker A motif; other site 1072459003951 ATP binding site [chemical binding]; other site 1072459003952 Walker B motif; other site 1072459003953 arginine finger; other site 1072459003954 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1072459003955 GTP-binding protein YchF; Reviewed; Region: PRK09601 1072459003956 YchF GTPase; Region: YchF; cd01900 1072459003957 G1 box; other site 1072459003958 GTP/Mg2+ binding site [chemical binding]; other site 1072459003959 Switch I region; other site 1072459003960 G2 box; other site 1072459003961 Switch II region; other site 1072459003962 G3 box; other site 1072459003963 G4 box; other site 1072459003964 G5 box; other site 1072459003965 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1072459003966 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1072459003967 putative active site [active] 1072459003968 catalytic residue [active] 1072459003969 hypothetical protein; Provisional; Region: PRK10692 1072459003970 putative transporter; Provisional; Region: PRK11660 1072459003971 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1072459003972 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1072459003973 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1072459003974 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1072459003975 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1072459003976 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1072459003977 active site 1072459003978 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 1072459003979 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1072459003980 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1072459003981 outer membrane lipoprotein LolB; Region: lolB; TIGR00548 1072459003982 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 1072459003983 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1072459003984 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1072459003985 tRNA; other site 1072459003986 putative tRNA binding site [nucleotide binding]; other site 1072459003987 putative NADP binding site [chemical binding]; other site 1072459003988 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1072459003989 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1072459003990 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1072459003991 RF-1 domain; Region: RF-1; pfam00472 1072459003992 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1072459003993 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1072459003994 hypothetical protein; Provisional; Region: PRK10278 1072459003995 hypothetical protein; Provisional; Region: PRK10941 1072459003996 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 1072459003997 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 1072459003998 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1072459003999 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 1072459004000 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 1072459004001 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 1072459004002 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1072459004003 cation transport regulator; Reviewed; Region: chaB; PRK09582 1072459004004 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 1072459004005 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1072459004006 putative active site pocket [active] 1072459004007 dimerization interface [polypeptide binding]; other site 1072459004008 putative catalytic residue [active] 1072459004009 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 1072459004010 putative invasin; Provisional; Region: PRK10177 1072459004011 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 1072459004012 transcriptional regulator NarL; Provisional; Region: PRK10651 1072459004013 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1072459004014 active site 1072459004015 phosphorylation site [posttranslational modification] 1072459004016 intermolecular recognition site; other site 1072459004017 dimerization interface [polypeptide binding]; other site 1072459004018 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1072459004019 DNA binding residues [nucleotide binding] 1072459004020 dimerization interface [polypeptide binding]; other site 1072459004021 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 1072459004022 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1072459004023 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1072459004024 dimerization interface [polypeptide binding]; other site 1072459004025 Histidine kinase; Region: HisKA_3; pfam07730 1072459004026 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1072459004027 ATP binding site [chemical binding]; other site 1072459004028 Mg2+ binding site [ion binding]; other site 1072459004029 G-X-G motif; other site 1072459004030 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 1072459004031 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 1072459004032 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1072459004033 [4Fe-4S] binding site [ion binding]; other site 1072459004034 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1072459004035 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1072459004036 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1072459004037 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1072459004038 molybdopterin cofactor binding site; other site 1072459004039 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1072459004040 4Fe-4S binding domain; Region: Fer4; cl02805 1072459004041 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1072459004042 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 1072459004043 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1072459004044 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1072459004045 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1072459004046 putative active site [active] 1072459004047 putative substrate binding site [chemical binding]; other site 1072459004048 putative cosubstrate binding site; other site 1072459004049 catalytic site [active] 1072459004050 SEC-C motif; Region: SEC-C; pfam02810 1072459004051 hypothetical protein; Provisional; Region: PRK04233 1072459004052 hypothetical protein; Provisional; Region: PRK10279 1072459004053 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 1072459004054 active site 1072459004055 nucleophile elbow; other site 1072459004056 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1072459004057 active site 1072459004058 response regulator of RpoS; Provisional; Region: PRK10693 1072459004059 phosphorylation site [posttranslational modification] 1072459004060 intermolecular recognition site; other site 1072459004061 dimerization interface [polypeptide binding]; other site 1072459004062 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1072459004063 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1072459004064 active site 1072459004065 tetramer interface; other site 1072459004066 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 1072459004067 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 1072459004068 Thymidine kinase [Nucleotide transport and metabolism]; Region: Tdk; COG1435 1072459004069 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 1072459004070 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1072459004071 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1072459004072 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1072459004073 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1072459004074 putative catalytic cysteine [active] 1072459004075 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1072459004076 putative active site [active] 1072459004077 metal binding site [ion binding]; metal-binding site 1072459004078 hypothetical protein; Provisional; Region: PRK11111 1072459004079 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 1072459004080 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1072459004081 peptide binding site [polypeptide binding]; other site 1072459004082 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 1072459004083 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1072459004084 dimer interface [polypeptide binding]; other site 1072459004085 conserved gate region; other site 1072459004086 putative PBP binding loops; other site 1072459004087 ABC-ATPase subunit interface; other site 1072459004088 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 1072459004089 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1072459004090 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1072459004091 dimer interface [polypeptide binding]; other site 1072459004092 conserved gate region; other site 1072459004093 putative PBP binding loops; other site 1072459004094 ABC-ATPase subunit interface; other site 1072459004095 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 1072459004096 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1072459004097 Walker A/P-loop; other site 1072459004098 ATP binding site [chemical binding]; other site 1072459004099 Q-loop/lid; other site 1072459004100 ABC transporter signature motif; other site 1072459004101 Walker B; other site 1072459004102 D-loop; other site 1072459004103 H-loop/switch region; other site 1072459004104 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1072459004105 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 1072459004106 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1072459004107 Walker A/P-loop; other site 1072459004108 ATP binding site [chemical binding]; other site 1072459004109 Q-loop/lid; other site 1072459004110 ABC transporter signature motif; other site 1072459004111 Walker B; other site 1072459004112 D-loop; other site 1072459004113 H-loop/switch region; other site 1072459004114 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1072459004115 dsDNA-mimic protein; Reviewed; Region: PRK05094 1072459004116 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1072459004117 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1072459004118 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 1072459004119 putative active site [active] 1072459004120 catalytic site [active] 1072459004121 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 1072459004122 putative active site [active] 1072459004123 catalytic site [active] 1072459004124 voltage-gated potassium channel; Provisional; Region: PRK10537 1072459004125 Ion channel; Region: Ion_trans_2; pfam07885 1072459004126 TrkA-N domain; Region: TrkA_N; pfam02254 1072459004127 YciI-like protein; Reviewed; Region: PRK11370 1072459004128 transport protein TonB; Provisional; Region: PRK10819 1072459004129 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1072459004130 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1072459004131 intracellular septation protein A; Reviewed; Region: PRK00259 1072459004132 hypothetical protein; Provisional; Region: PRK02868 1072459004133 outer membrane protein W; Provisional; Region: PRK10959 1072459004134 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 1072459004135 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1072459004136 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 1072459004137 dimer interface [polypeptide binding]; other site 1072459004138 active site 1072459004139 Int/Topo IB signature motif; other site 1072459004140 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 1072459004141 DicB protein; Region: DicB; pfam05358 1072459004142 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 1072459004143 transcriptional repressor DicA; Reviewed; Region: PRK09706 1072459004144 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 1072459004145 Helix-turn-helix domain; Region: HTH_36; pfam13730 1072459004146 primosomal protein DnaI; Provisional; Region: PRK02854 1072459004147 putative replication protein; Provisional; Region: PRK12377 1072459004148 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1072459004149 Walker A motif; other site 1072459004150 ATP binding site [chemical binding]; other site 1072459004151 Walker B motif; other site 1072459004152 arginine finger; other site 1072459004153 Protein of unknown function (DUF1627); Region: DUF1627; pfam07789 1072459004154 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 1072459004155 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 1072459004156 Protein of unknown function (DUF968); Region: DUF968; pfam06147 1072459004157 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 1072459004158 Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323 1072459004159 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1072459004160 DNA methylase; Region: N6_N4_Mtase; pfam01555 1072459004161 DNA methylase; Region: N6_N4_Mtase; pfam01555 1072459004162 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1072459004163 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 1072459004164 Domain of unknown function (DUF303); Region: DUF303; pfam03629 1072459004165 Lysis protein S; Region: Lysis_S; pfam04971 1072459004166 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 1072459004167 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1072459004168 catalytic residues [active] 1072459004169 putative transposase OrfB; Reviewed; Region: PHA02517 1072459004170 HTH-like domain; Region: HTH_21; pfam13276 1072459004171 Integrase core domain; Region: rve; pfam00665 1072459004172 Integrase core domain; Region: rve_3; pfam13683 1072459004173 Phage DNA packaging protein, Nu1 subunit of terminase [DNA replication, recombination, and repair]; Region: COG4220 1072459004174 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 1072459004175 gpW; Region: gpW; pfam02831 1072459004176 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 1072459004177 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 1072459004178 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 1072459004179 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1072459004180 tandem repeat interface [polypeptide binding]; other site 1072459004181 oligomer interface [polypeptide binding]; other site 1072459004182 active site residues [active] 1072459004183 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 1072459004184 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 1072459004185 DNA packaging protein FI; Region: Packaging_FI; pfam14000 1072459004186 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 1072459004187 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 1072459004188 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 1072459004189 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 1072459004190 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 1072459004191 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894 1072459004192 Minor tail protein T; Region: Phage_tail_T; cl05636 1072459004193 Phage-related minor tail protein [Function unknown]; Region: COG5281 1072459004194 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 1072459004195 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 1072459004196 Phage-related protein [Function unknown]; Region: COG4718 1072459004197 Phage-related protein [Function unknown]; Region: gp18; COG4672 1072459004198 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 1072459004199 MPN+ (JAMM) motif; other site 1072459004200 Zinc-binding site [ion binding]; other site 1072459004201 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1072459004202 NlpC/P60 family; Region: NLPC_P60; cl17555 1072459004203 Phage-related protein, tail component [Function unknown]; Region: COG4723 1072459004204 Phage-related protein, tail component [Function unknown]; Region: COG4733 1072459004205 Putative phage tail protein; Region: Phage-tail_3; pfam13550 1072459004206 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1072459004207 Interdomain contacts; other site 1072459004208 Cytokine receptor motif; other site 1072459004209 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 1072459004210 Fibronectin type III protein; Region: DUF3672; pfam12421 1072459004211 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 1072459004212 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 1072459004213 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 1072459004214 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 1072459004215 dimerization interface [polypeptide binding]; other site 1072459004216 metal binding site [ion binding]; metal-binding site 1072459004217 General stress protein [General function prediction only]; Region: GsiB; COG3729 1072459004218 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1072459004219 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1072459004220 substrate binding site [chemical binding]; other site 1072459004221 active site 1072459004222 catalytic residues [active] 1072459004223 heterodimer interface [polypeptide binding]; other site 1072459004224 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1072459004225 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1072459004226 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1072459004227 catalytic residue [active] 1072459004228 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 1072459004229 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1072459004230 active site 1072459004231 ribulose/triose binding site [chemical binding]; other site 1072459004232 phosphate binding site [ion binding]; other site 1072459004233 substrate (anthranilate) binding pocket [chemical binding]; other site 1072459004234 product (indole) binding pocket [chemical binding]; other site 1072459004235 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1072459004236 active site 1072459004237 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 1072459004238 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1072459004239 glutamine binding [chemical binding]; other site 1072459004240 catalytic triad [active] 1072459004241 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1072459004242 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1072459004243 anthranilate synthase component I; Provisional; Region: PRK13564 1072459004244 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1072459004245 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1072459004246 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1072459004247 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1072459004248 active site 1072459004249 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1072459004250 hypothetical protein; Provisional; Region: PRK11630 1072459004251 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 1072459004252 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 1072459004253 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1072459004254 RNA binding surface [nucleotide binding]; other site 1072459004255 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 1072459004256 probable active site [active] 1072459004257 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1072459004258 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1072459004259 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 1072459004260 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1072459004261 homodimer interface [polypeptide binding]; other site 1072459004262 Walker A motif; other site 1072459004263 ATP binding site [chemical binding]; other site 1072459004264 hydroxycobalamin binding site [chemical binding]; other site 1072459004265 Walker B motif; other site 1072459004266 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 1072459004267 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 1072459004268 NADP binding site [chemical binding]; other site 1072459004269 homodimer interface [polypeptide binding]; other site 1072459004270 active site 1072459004271 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 1072459004272 putative inner membrane peptidase; Provisional; Region: PRK11778 1072459004273 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1072459004274 tandem repeat interface [polypeptide binding]; other site 1072459004275 oligomer interface [polypeptide binding]; other site 1072459004276 active site residues [active] 1072459004277 hypothetical protein; Provisional; Region: PRK11037 1072459004278 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1072459004279 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1072459004280 active site 1072459004281 interdomain interaction site; other site 1072459004282 putative metal-binding site [ion binding]; other site 1072459004283 nucleotide binding site [chemical binding]; other site 1072459004284 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1072459004285 domain I; other site 1072459004286 DNA binding groove [nucleotide binding] 1072459004287 phosphate binding site [ion binding]; other site 1072459004288 domain II; other site 1072459004289 domain III; other site 1072459004290 nucleotide binding site [chemical binding]; other site 1072459004291 catalytic site [active] 1072459004292 domain IV; other site 1072459004293 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1072459004294 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1072459004295 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1072459004296 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1072459004297 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 1072459004298 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1072459004299 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 1072459004300 substrate binding site [chemical binding]; other site 1072459004301 putative dimerization interface [polypeptide binding]; other site 1072459004302 aconitate hydratase; Validated; Region: PRK09277 1072459004303 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1072459004304 substrate binding site [chemical binding]; other site 1072459004305 ligand binding site [chemical binding]; other site 1072459004306 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1072459004307 substrate binding site [chemical binding]; other site 1072459004308 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1072459004309 dimerization interface [polypeptide binding]; other site 1072459004310 active site 1072459004311 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1072459004312 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1072459004313 active site 1072459004314 Predicted membrane protein [Function unknown]; Region: COG3771 1072459004315 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 1072459004316 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1072459004317 TPR motif; other site 1072459004318 binding surface 1072459004319 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1072459004320 binding surface 1072459004321 TPR motif; other site 1072459004322 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1072459004323 active site 1072459004324 dimer interface [polypeptide binding]; other site 1072459004325 translation initiation factor Sui1; Validated; Region: PRK06824 1072459004326 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 1072459004327 putative rRNA binding site [nucleotide binding]; other site 1072459004328 lipoprotein; Provisional; Region: PRK10540 1072459004329 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1072459004330 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1072459004331 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1072459004332 hypothetical protein; Provisional; Region: PRK13658 1072459004333 RNase II stability modulator; Provisional; Region: PRK10060 1072459004334 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1072459004335 putative active site [active] 1072459004336 heme pocket [chemical binding]; other site 1072459004337 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1072459004338 metal binding site [ion binding]; metal-binding site 1072459004339 active site 1072459004340 I-site; other site 1072459004341 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1072459004342 exoribonuclease II; Provisional; Region: PRK05054 1072459004343 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1072459004344 RNB domain; Region: RNB; pfam00773 1072459004345 S1 RNA binding domain; Region: S1; pfam00575 1072459004346 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 1072459004347 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1072459004348 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 1072459004349 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1072459004350 NAD binding site [chemical binding]; other site 1072459004351 homotetramer interface [polypeptide binding]; other site 1072459004352 homodimer interface [polypeptide binding]; other site 1072459004353 substrate binding site [chemical binding]; other site 1072459004354 active site 1072459004355 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1072459004356 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1072459004357 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 1072459004358 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1072459004359 HlyD family secretion protein; Region: HlyD_3; pfam13437 1072459004360 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1072459004361 Protein export membrane protein; Region: SecD_SecF; cl14618 1072459004362 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1072459004363 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1072459004364 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459004365 putative substrate translocation pore; other site 1072459004366 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 1072459004367 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1072459004368 Walker A/P-loop; other site 1072459004369 ATP binding site [chemical binding]; other site 1072459004370 Q-loop/lid; other site 1072459004371 ABC transporter signature motif; other site 1072459004372 Walker B; other site 1072459004373 D-loop; other site 1072459004374 H-loop/switch region; other site 1072459004375 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 1072459004376 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1072459004377 Walker A/P-loop; other site 1072459004378 ATP binding site [chemical binding]; other site 1072459004379 Q-loop/lid; other site 1072459004380 ABC transporter signature motif; other site 1072459004381 Walker B; other site 1072459004382 D-loop; other site 1072459004383 H-loop/switch region; other site 1072459004384 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1072459004385 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 1072459004386 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1072459004387 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1072459004388 dimer interface [polypeptide binding]; other site 1072459004389 conserved gate region; other site 1072459004390 putative PBP binding loops; other site 1072459004391 ABC-ATPase subunit interface; other site 1072459004392 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 1072459004393 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1072459004394 dimer interface [polypeptide binding]; other site 1072459004395 conserved gate region; other site 1072459004396 putative PBP binding loops; other site 1072459004397 ABC-ATPase subunit interface; other site 1072459004398 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1072459004399 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1072459004400 peptide binding site [polypeptide binding]; other site 1072459004401 Protein of unknown function (DUF2543); Region: DUF2543; pfam10820 1072459004402 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1072459004403 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1072459004404 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1072459004405 gamma-glutamyl-gamma-aminobutyrate hydrolase; Provisional; Region: puuD; PRK11366 1072459004406 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1072459004407 catalytic triad [active] 1072459004408 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1072459004409 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1072459004410 non-specific DNA binding site [nucleotide binding]; other site 1072459004411 salt bridge; other site 1072459004412 sequence-specific DNA binding site [nucleotide binding]; other site 1072459004413 Cupin domain; Region: Cupin_2; pfam07883 1072459004414 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1072459004415 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1072459004416 4-aminobutyrate transaminase; Provisional; Region: PRK09792 1072459004417 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1072459004418 inhibitor-cofactor binding pocket; inhibition site 1072459004419 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1072459004420 catalytic residue [active] 1072459004421 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 1072459004422 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1072459004423 Walker A motif; other site 1072459004424 ATP binding site [chemical binding]; other site 1072459004425 Walker B motif; other site 1072459004426 arginine finger; other site 1072459004427 phage shock protein PspA; Provisional; Region: PRK10698 1072459004428 phage shock protein B; Provisional; Region: pspB; PRK09458 1072459004429 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 1072459004430 phage shock protein C; Region: phageshock_pspC; TIGR02978 1072459004431 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 1072459004432 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1072459004433 active site residue [active] 1072459004434 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 1072459004435 sucrose phosphorylase; Provisional; Region: PRK13840 1072459004436 active site 1072459004437 homodimer interface [polypeptide binding]; other site 1072459004438 catalytic site [active] 1072459004439 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1072459004440 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1072459004441 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1072459004442 dimer interface [polypeptide binding]; other site 1072459004443 conserved gate region; other site 1072459004444 putative PBP binding loops; other site 1072459004445 ABC-ATPase subunit interface; other site 1072459004446 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1072459004447 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1072459004448 dimer interface [polypeptide binding]; other site 1072459004449 conserved gate region; other site 1072459004450 putative PBP binding loops; other site 1072459004451 ABC-ATPase subunit interface; other site 1072459004452 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1072459004453 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 1072459004454 putative NAD(P) binding site [chemical binding]; other site 1072459004455 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1072459004456 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1072459004457 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1072459004458 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1072459004459 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1072459004460 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1072459004461 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1072459004462 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1072459004463 beta-phosphoglucomutase; Region: bPGM; TIGR01990 1072459004464 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1072459004465 motif II; other site 1072459004466 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1072459004467 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1072459004468 Walker A/P-loop; other site 1072459004469 ATP binding site [chemical binding]; other site 1072459004470 Q-loop/lid; other site 1072459004471 ABC transporter signature motif; other site 1072459004472 Walker B; other site 1072459004473 D-loop; other site 1072459004474 H-loop/switch region; other site 1072459004475 TOBE domain; Region: TOBE_2; pfam08402 1072459004476 Outer membrane protein G (OmpG); Region: Porin_OmpG; pfam09381 1072459004477 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1072459004478 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1072459004479 DNA binding site [nucleotide binding] 1072459004480 domain linker motif; other site 1072459004481 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 1072459004482 putative dimerization interface [polypeptide binding]; other site 1072459004483 putative ligand binding site [chemical binding]; other site 1072459004484 Predicted ATPase [General function prediction only]; Region: COG3106 1072459004485 hypothetical protein; Provisional; Region: PRK05415 1072459004486 TIGR01620 family protein; Region: hyp_HI0043 1072459004487 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 1072459004488 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 1072459004489 putative aromatic amino acid binding site; other site 1072459004490 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1072459004491 Walker A motif; other site 1072459004492 ATP binding site [chemical binding]; other site 1072459004493 Walker B motif; other site 1072459004494 arginine finger; other site 1072459004495 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1072459004496 dimer interface [polypeptide binding]; other site 1072459004497 catalytic triad [active] 1072459004498 peroxidatic and resolving cysteines [active] 1072459004499 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 1072459004500 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1072459004501 active site 1072459004502 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 1072459004503 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 1072459004504 putative active site [active] 1072459004505 Zn binding site [ion binding]; other site 1072459004506 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 1072459004507 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1072459004508 peptide binding site [polypeptide binding]; other site 1072459004509 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1072459004510 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1072459004511 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 1072459004512 universal stress protein UspE; Provisional; Region: PRK11175 1072459004513 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1072459004514 Ligand Binding Site [chemical binding]; other site 1072459004515 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1072459004516 Ligand Binding Site [chemical binding]; other site 1072459004517 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 1072459004518 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1072459004519 ligand binding site [chemical binding]; other site 1072459004520 flexible hinge region; other site 1072459004521 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1072459004522 putative switch regulator; other site 1072459004523 non-specific DNA interactions [nucleotide binding]; other site 1072459004524 DNA binding site [nucleotide binding] 1072459004525 sequence specific DNA binding site [nucleotide binding]; other site 1072459004526 putative cAMP binding site [chemical binding]; other site 1072459004527 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 1072459004528 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1072459004529 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1072459004530 DNA binding site [nucleotide binding] 1072459004531 active site 1072459004532 putative aminobenzoyl-glutamate transporter; Provisional; Region: abgT; PRK11339 1072459004533 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 1072459004534 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 1072459004535 putative metal binding site [ion binding]; other site 1072459004536 M20 Peptidases Aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase from bacteria and archaea; Region: M20_Acy1_IAAspH_bact; cd05665 1072459004537 amidohydrolase; Region: amidohydrolases; TIGR01891 1072459004538 putative metal binding site [ion binding]; other site 1072459004539 dimer interface [polypeptide binding]; other site 1072459004540 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1072459004541 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1072459004542 dimerization interface [polypeptide binding]; other site 1072459004543 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 1072459004544 Smr domain; Region: Smr; pfam01713 1072459004545 PAS domain S-box; Region: sensory_box; TIGR00229 1072459004546 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1072459004547 putative active site [active] 1072459004548 heme pocket [chemical binding]; other site 1072459004549 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1072459004550 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1072459004551 metal binding site [ion binding]; metal-binding site 1072459004552 active site 1072459004553 I-site; other site 1072459004554 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1072459004555 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 1072459004556 Cl binding site [ion binding]; other site 1072459004557 oligomer interface [polypeptide binding]; other site 1072459004558 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 1072459004559 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1072459004560 ATP binding site [chemical binding]; other site 1072459004561 Mg++ binding site [ion binding]; other site 1072459004562 motif III; other site 1072459004563 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1072459004564 nucleotide binding region [chemical binding]; other site 1072459004565 ATP-binding site [chemical binding]; other site 1072459004566 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 1072459004567 putative RNA binding site [nucleotide binding]; other site 1072459004568 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 1072459004569 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 1072459004570 Ligand Binding Site [chemical binding]; other site 1072459004571 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1072459004572 Ligand Binding Site [chemical binding]; other site 1072459004573 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1072459004574 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1072459004575 trimer interface [polypeptide binding]; other site 1072459004576 eyelet of channel; other site 1072459004577 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 1072459004578 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1072459004579 dimer interface [polypeptide binding]; other site 1072459004580 PYR/PP interface [polypeptide binding]; other site 1072459004581 TPP binding site [chemical binding]; other site 1072459004582 substrate binding site [chemical binding]; other site 1072459004583 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1072459004584 Domain of unknown function; Region: EKR; smart00890 1072459004585 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1072459004586 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1072459004587 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 1072459004588 TPP-binding site [chemical binding]; other site 1072459004589 dimer interface [polypeptide binding]; other site 1072459004590 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 1072459004591 Domain of unknown function (DUF333); Region: DUF333; pfam03891 1072459004592 heat-inducible protein; Provisional; Region: PRK10449 1072459004593 putative transposase OrfB; Reviewed; Region: PHA02517 1072459004594 HTH-like domain; Region: HTH_21; pfam13276 1072459004595 Integrase core domain; Region: rve; pfam00665 1072459004596 Integrase core domain; Region: rve_3; pfam13683 1072459004597 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 1072459004598 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1072459004599 putative ligand binding site [chemical binding]; other site 1072459004600 putative NAD binding site [chemical binding]; other site 1072459004601 catalytic site [active] 1072459004602 hypothetical protein; Provisional; Region: PRK10695 1072459004603 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 1072459004604 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 1072459004605 putative transposase OrfB; Reviewed; Region: PHA02517 1072459004606 HTH-like domain; Region: HTH_21; pfam13276 1072459004607 Integrase core domain; Region: rve; pfam00665 1072459004608 Integrase core domain; Region: rve_3; pfam13683 1072459004609 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1072459004610 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1072459004611 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1072459004612 active site 1072459004613 catalytic tetrad [active] 1072459004614 Protein of unknown function (DUF2773); Region: DUF2773; pfam10971 1072459004615 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1072459004616 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 1072459004617 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1072459004618 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1072459004619 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1072459004620 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1072459004621 S-adenosylmethionine binding site [chemical binding]; other site 1072459004622 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 1072459004623 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1072459004624 active site 1072459004625 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1072459004626 active site 1072459004627 catalytic residues [active] 1072459004628 azoreductase; Reviewed; Region: PRK00170 1072459004629 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1072459004630 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 1072459004631 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1072459004632 ATP binding site [chemical binding]; other site 1072459004633 putative Mg++ binding site [ion binding]; other site 1072459004634 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1072459004635 nucleotide binding region [chemical binding]; other site 1072459004636 ATP-binding site [chemical binding]; other site 1072459004637 Helicase associated domain (HA2); Region: HA2; pfam04408 1072459004638 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1072459004639 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1072459004640 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1072459004641 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1072459004642 putative active site [active] 1072459004643 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 1072459004644 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1072459004645 NAD binding site [chemical binding]; other site 1072459004646 catalytic residues [active] 1072459004647 substrate binding site [chemical binding]; other site 1072459004648 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1072459004649 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1072459004650 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1072459004651 cytochrome b561; Provisional; Region: PRK11513 1072459004652 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 1072459004653 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1072459004654 dimer interface [polypeptide binding]; other site 1072459004655 ligand binding site [chemical binding]; other site 1072459004656 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1072459004657 dimerization interface [polypeptide binding]; other site 1072459004658 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1072459004659 dimer interface [polypeptide binding]; other site 1072459004660 putative CheW interface [polypeptide binding]; other site 1072459004661 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1072459004662 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1072459004663 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1072459004664 dimerization interface [polypeptide binding]; other site 1072459004665 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 1072459004666 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 1072459004667 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 1072459004668 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 1072459004669 hypothetical protein; Provisional; Region: PRK11415 1072459004670 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1072459004671 putative trimer interface [polypeptide binding]; other site 1072459004672 putative CoA binding site [chemical binding]; other site 1072459004673 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 1072459004674 putative trimer interface [polypeptide binding]; other site 1072459004675 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1072459004676 putative CoA binding site [chemical binding]; other site 1072459004677 putative trimer interface [polypeptide binding]; other site 1072459004678 putative CoA binding site [chemical binding]; other site 1072459004679 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 1072459004680 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 1072459004681 gating phenylalanine in ion channel; other site 1072459004682 tellurite resistance protein TehB; Provisional; Region: PRK11207 1072459004683 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1072459004684 S-adenosylmethionine binding site [chemical binding]; other site 1072459004685 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 1072459004686 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 1072459004687 benzoate transporter; Region: benE; TIGR00843 1072459004688 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1072459004689 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1072459004690 non-specific DNA binding site [nucleotide binding]; other site 1072459004691 salt bridge; other site 1072459004692 sequence-specific DNA binding site [nucleotide binding]; other site 1072459004693 Cupin domain; Region: Cupin_2; pfam07883 1072459004694 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1072459004695 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1072459004696 Peptidase family U32; Region: Peptidase_U32; pfam01136 1072459004697 Collagenase; Region: DUF3656; pfam12392 1072459004698 Protein of unknown function (DUF2554); Region: DUF2554; pfam10829 1072459004699 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1072459004700 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1072459004701 DNA-binding site [nucleotide binding]; DNA binding site 1072459004702 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1072459004703 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1072459004704 homodimer interface [polypeptide binding]; other site 1072459004705 catalytic residue [active] 1072459004706 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1072459004707 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1072459004708 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1072459004709 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1072459004710 Walker A/P-loop; other site 1072459004711 ATP binding site [chemical binding]; other site 1072459004712 Q-loop/lid; other site 1072459004713 ABC transporter signature motif; other site 1072459004714 Walker B; other site 1072459004715 D-loop; other site 1072459004716 H-loop/switch region; other site 1072459004717 TOBE domain; Region: TOBE_2; pfam08402 1072459004718 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1072459004719 dimer interface [polypeptide binding]; other site 1072459004720 conserved gate region; other site 1072459004721 putative PBP binding loops; other site 1072459004722 ABC-ATPase subunit interface; other site 1072459004723 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1072459004724 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1072459004725 ABC-ATPase subunit interface; other site 1072459004726 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 1072459004727 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 1072459004728 tetrameric interface [polypeptide binding]; other site 1072459004729 NAD binding site [chemical binding]; other site 1072459004730 catalytic residues [active] 1072459004731 substrate binding site [chemical binding]; other site 1072459004732 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 1072459004733 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 1072459004734 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 1072459004735 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1072459004736 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1072459004737 Coenzyme A binding pocket [chemical binding]; other site 1072459004738 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1072459004739 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1072459004740 NAD(P) binding site [chemical binding]; other site 1072459004741 substrate binding site [chemical binding]; other site 1072459004742 dimer interface [polypeptide binding]; other site 1072459004743 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 1072459004744 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1072459004745 DNA-binding site [nucleotide binding]; DNA binding site 1072459004746 FCD domain; Region: FCD; pfam07729 1072459004747 PQQ-like domain; Region: PQQ_2; pfam13360 1072459004748 L-asparagine permease; Provisional; Region: PRK15049 1072459004749 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1072459004750 C-terminal domain interface [polypeptide binding]; other site 1072459004751 GSH binding site (G-site) [chemical binding]; other site 1072459004752 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1072459004753 dimer interface [polypeptide binding]; other site 1072459004754 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1072459004755 N-terminal domain interface [polypeptide binding]; other site 1072459004756 dimer interface [polypeptide binding]; other site 1072459004757 substrate binding pocket (H-site) [chemical binding]; other site 1072459004758 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1072459004759 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1072459004760 metal binding site [ion binding]; metal-binding site 1072459004761 active site 1072459004762 I-site; other site 1072459004763 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 1072459004764 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1072459004765 SCP-2 sterol transfer family; Region: SCP2; cl01225 1072459004766 4-oxalocrotonate tautomerase; Provisional; Region: PRK01271 1072459004767 active site 1 [active] 1072459004768 dimer interface [polypeptide binding]; other site 1072459004769 hexamer interface [polypeptide binding]; other site 1072459004770 active site 2 [active] 1072459004771 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1072459004772 N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047 1072459004773 hypothetical protein; Provisional; Region: PRK10281 1072459004774 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 1072459004775 nitrate reductase 2 subunit delta; Provisional; Region: PRK15054 1072459004776 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1072459004777 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1072459004778 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1072459004779 [4Fe-4S] binding site [ion binding]; other site 1072459004780 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1072459004781 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1072459004782 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1072459004783 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1072459004784 molybdopterin cofactor binding site; other site 1072459004785 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 1072459004786 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 1072459004787 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1072459004788 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1072459004789 trimer interface [polypeptide binding]; other site 1072459004790 eyelet of channel; other site 1072459004791 aromatic amino acid exporter; Provisional; Region: PRK11689 1072459004792 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 1072459004793 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 1072459004794 [4Fe-4S] binding site [ion binding]; other site 1072459004795 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1072459004796 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 1072459004797 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1072459004798 molybdopterin cofactor binding site; other site 1072459004799 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 1072459004800 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 1072459004801 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 1072459004802 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 1072459004803 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 1072459004804 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1072459004805 non-specific DNA binding site [nucleotide binding]; other site 1072459004806 salt bridge; other site 1072459004807 sequence-specific DNA binding site [nucleotide binding]; other site 1072459004808 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 1072459004809 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1072459004810 NAD binding site [chemical binding]; other site 1072459004811 substrate binding site [chemical binding]; other site 1072459004812 catalytic Zn binding site [ion binding]; other site 1072459004813 tetramer interface [polypeptide binding]; other site 1072459004814 structural Zn binding site [ion binding]; other site 1072459004815 malate dehydrogenase; Provisional; Region: PRK13529 1072459004816 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1072459004817 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1072459004818 NAD(P) binding site [chemical binding]; other site 1072459004819 30S ribosomal subunit S22; Reviewed; Region: rpsV; PRK10057 1072459004820 Putative biofilm-dependent modulation protein; Region: BDM; cl11581 1072459004821 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 1072459004822 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1072459004823 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1072459004824 Walker A/P-loop; other site 1072459004825 ATP binding site [chemical binding]; other site 1072459004826 Q-loop/lid; other site 1072459004827 ABC transporter signature motif; other site 1072459004828 Walker B; other site 1072459004829 D-loop; other site 1072459004830 H-loop/switch region; other site 1072459004831 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1072459004832 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1072459004833 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1072459004834 Walker A/P-loop; other site 1072459004835 ATP binding site [chemical binding]; other site 1072459004836 Q-loop/lid; other site 1072459004837 ABC transporter signature motif; other site 1072459004838 Walker B; other site 1072459004839 D-loop; other site 1072459004840 H-loop/switch region; other site 1072459004841 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1072459004842 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 1072459004843 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1072459004844 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1072459004845 dimer interface [polypeptide binding]; other site 1072459004846 conserved gate region; other site 1072459004847 putative PBP binding loops; other site 1072459004848 ABC-ATPase subunit interface; other site 1072459004849 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1072459004850 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1072459004851 dimer interface [polypeptide binding]; other site 1072459004852 conserved gate region; other site 1072459004853 putative PBP binding loops; other site 1072459004854 ABC-ATPase subunit interface; other site 1072459004855 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1072459004856 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 1072459004857 D-alanyl-D-alanine dipeptidase; Provisional; Region: PRK10178 1072459004858 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 1072459004859 heme-binding site [chemical binding]; other site 1072459004860 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1072459004861 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1072459004862 metal binding site [ion binding]; metal-binding site 1072459004863 active site 1072459004864 I-site; other site 1072459004865 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 1072459004866 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1072459004867 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 1072459004868 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1072459004869 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1072459004870 catalytic residue [active] 1072459004871 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1072459004872 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1072459004873 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1072459004874 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1072459004875 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1072459004876 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1072459004877 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1072459004878 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 1072459004879 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 1072459004880 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 1072459004881 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 1072459004882 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1072459004883 FeS/SAM binding site; other site 1072459004884 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1072459004885 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1072459004886 Sulfatase; Region: Sulfatase; pfam00884 1072459004887 transcriptional regulator YdeO; Provisional; Region: PRK09940 1072459004888 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1072459004889 putative oxidoreductase; Provisional; Region: PRK09939 1072459004890 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1072459004891 putative molybdopterin cofactor binding site [chemical binding]; other site 1072459004892 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1072459004893 putative molybdopterin cofactor binding site; other site 1072459004894 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 1072459004895 mannosyl binding site [chemical binding]; other site 1072459004896 Fimbrial protein; Region: Fimbrial; cl01416 1072459004897 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1072459004898 IS2 repressor TnpA; Reviewed; Region: PRK09413 1072459004899 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1072459004900 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1072459004901 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1072459004902 non-specific DNA binding site [nucleotide binding]; other site 1072459004903 salt bridge; other site 1072459004904 sequence-specific DNA binding site [nucleotide binding]; other site 1072459004905 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 1072459004906 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 1072459004907 putative N- and C-terminal domain interface [polypeptide binding]; other site 1072459004908 putative active site [active] 1072459004909 putative MgATP binding site [chemical binding]; other site 1072459004910 catalytic site [active] 1072459004911 metal binding site [ion binding]; metal-binding site 1072459004912 putative carbohydrate binding site [chemical binding]; other site 1072459004913 transcriptional regulator LsrR; Provisional; Region: PRK15418 1072459004914 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1072459004915 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1072459004916 autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439 1072459004917 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1072459004918 Walker A/P-loop; other site 1072459004919 ATP binding site [chemical binding]; other site 1072459004920 Q-loop/lid; other site 1072459004921 ABC transporter signature motif; other site 1072459004922 Walker B; other site 1072459004923 D-loop; other site 1072459004924 H-loop/switch region; other site 1072459004925 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1072459004926 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1072459004927 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1072459004928 TM-ABC transporter signature motif; other site 1072459004929 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1072459004930 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1072459004931 TM-ABC transporter signature motif; other site 1072459004932 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 1072459004933 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 1072459004934 ligand binding site [chemical binding]; other site 1072459004935 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 1072459004936 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1072459004937 putative active site; other site 1072459004938 catalytic residue [active] 1072459004939 autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486 1072459004940 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 1072459004941 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1072459004942 S-adenosylmethionine binding site [chemical binding]; other site 1072459004943 Predicted membrane protein [Function unknown]; Region: COG3781 1072459004944 altronate oxidoreductase; Provisional; Region: PRK03643 1072459004945 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1072459004946 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1072459004947 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1072459004948 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1072459004949 metal binding site [ion binding]; metal-binding site 1072459004950 active site 1072459004951 I-site; other site 1072459004952 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 1072459004953 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1072459004954 glutaminase; Provisional; Region: PRK00971 1072459004955 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 1072459004956 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1072459004957 NAD(P) binding site [chemical binding]; other site 1072459004958 catalytic residues [active] 1072459004959 DNA-binding transcriptional regulator; Provisional; Region: PRK09678 1072459004960 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 1072459004961 tail protein; Provisional; Region: D; PHA02561 1072459004962 Phage protein U [General function prediction only]; Region: COG3499 1072459004963 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1072459004964 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 1072459004965 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 1072459004966 major tail tube protein; Provisional; Region: FII; PHA02600 1072459004967 major tail sheath protein; Provisional; Region: FI; PHA02560 1072459004968 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1072459004969 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1072459004970 catalytic residues [active] 1072459004971 catalytic nucleophile [active] 1072459004972 Presynaptic Site I dimer interface [polypeptide binding]; other site 1072459004973 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1072459004974 Synaptic Flat tetramer interface [polypeptide binding]; other site 1072459004975 Synaptic Site I dimer interface [polypeptide binding]; other site 1072459004976 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1072459004977 DNA-binding interface [nucleotide binding]; DNA binding site 1072459004978 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1072459004979 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1072459004980 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 1072459004981 Phage Tail Collar Domain; Region: Collar; pfam07484 1072459004982 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 1072459004983 baseplate assembly protein; Provisional; Region: J; PHA02568 1072459004984 baseplate wedge subunit; Provisional; Region: W; PHA02516 1072459004985 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 1072459004986 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 1072459004987 Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069 1072459004988 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 1072459004989 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 1072459004990 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1072459004991 catalytic residues [active] 1072459004992 P2-like prophage tail protein X [General function prediction only]; Region: COG5004 1072459004993 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 1072459004994 terminase endonuclease subunit; Provisional; Region: M; PHA02537 1072459004995 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 1072459004996 capsid protein; Provisional; Region: N; PHA02538 1072459004997 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; pfam05929 1072459004998 terminase ATPase subunit; Provisional; Region: P; PHA02535 1072459004999 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 1072459005000 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 1072459005001 portal vertex protein; Provisional; Region: Q; PHA02536 1072459005002 Phage portal protein; Region: Phage_portal; pfam04860 1072459005003 putative transposase OrfB; Reviewed; Region: PHA02517 1072459005004 HTH-like domain; Region: HTH_21; pfam13276 1072459005005 Integrase core domain; Region: rve; pfam00665 1072459005006 Integrase core domain; Region: rve_3; pfam13683 1072459005007 Predicted transcriptional regulator [Transcription]; Region: COG2932 1072459005008 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 1072459005009 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1072459005010 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1072459005011 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 1072459005012 integrase; Provisional; Region: int; PHA02601 1072459005013 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1072459005014 active site 1072459005015 DNA binding site [nucleotide binding] 1072459005016 Int/Topo IB signature motif; other site 1072459005017 putative arabinose transporter; Provisional; Region: PRK03545 1072459005018 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459005019 putative substrate translocation pore; other site 1072459005020 inner membrane protein; Provisional; Region: PRK10995 1072459005021 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 1072459005022 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1072459005023 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 1072459005024 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1072459005025 MarB protein; Region: MarB; cl08087 1072459005026 6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589 1072459005027 beta-galactosidase; Region: BGL; TIGR03356 1072459005028 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 1072459005029 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1072459005030 trimer interface; other site 1072459005031 sugar binding site [chemical binding]; other site 1072459005032 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1072459005033 active site 1072459005034 methionine cluster; other site 1072459005035 phosphorylation site [posttranslational modification] 1072459005036 metal binding site [ion binding]; metal-binding site 1072459005037 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1072459005038 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1072459005039 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1072459005040 active site 1072459005041 P-loop; other site 1072459005042 phosphorylation site [posttranslational modification] 1072459005043 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1072459005044 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1072459005045 DNA-binding site [nucleotide binding]; DNA binding site 1072459005046 UTRA domain; Region: UTRA; pfam07702 1072459005047 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 1072459005048 EamA-like transporter family; Region: EamA; pfam00892 1072459005049 putative transporter; Provisional; Region: PRK10054 1072459005050 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459005051 putative substrate translocation pore; other site 1072459005052 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 1072459005053 active site residue [active] 1072459005054 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1072459005055 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1072459005056 conserved cys residue [active] 1072459005057 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1072459005058 diguanylate cyclase; Provisional; Region: PRK09894 1072459005059 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 1072459005060 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1072459005061 metal binding site [ion binding]; metal-binding site 1072459005062 active site 1072459005063 I-site; other site 1072459005064 hypothetical protein; Provisional; Region: PRK10053 1072459005065 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 1072459005066 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1072459005067 active site 1072459005068 Zn binding site [ion binding]; other site 1072459005069 malonic semialdehyde reductase; Provisional; Region: PRK10538 1072459005070 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 1072459005071 putative NAD(P) binding site [chemical binding]; other site 1072459005072 homodimer interface [polypeptide binding]; other site 1072459005073 homotetramer interface [polypeptide binding]; other site 1072459005074 active site 1072459005075 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1072459005076 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1072459005077 DNA-binding site [nucleotide binding]; DNA binding site 1072459005078 FCD domain; Region: FCD; pfam07729 1072459005079 putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318 1072459005080 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1072459005081 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1072459005082 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1072459005083 metabolite-proton symporter; Region: 2A0106; TIGR00883 1072459005084 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459005085 putative substrate translocation pore; other site 1072459005086 putative transposase OrfB; Reviewed; Region: PHA02517 1072459005087 HTH-like domain; Region: HTH_21; pfam13276 1072459005088 Integrase core domain; Region: rve; pfam00665 1072459005089 Integrase core domain; Region: rve_3; pfam13683 1072459005090 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 1072459005091 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 1072459005092 Phage-related protein, tail component [Function unknown]; Region: COG4733 1072459005093 Putative phage tail protein; Region: Phage-tail_3; pfam13550 1072459005094 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 1072459005095 Fibronectin type III protein; Region: DUF3672; pfam12421 1072459005096 Phage-related protein, tail component [Function unknown]; Region: COG4723 1072459005097 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 1072459005098 MPN+ (JAMM) motif; other site 1072459005099 Zinc-binding site [ion binding]; other site 1072459005100 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1072459005101 NlpC/P60 family; Region: NLPC_P60; cl17555 1072459005102 Phage-related protein [Function unknown]; Region: gp18; COG4672 1072459005103 Phage-related protein [Function unknown]; Region: COG4718 1072459005104 Phage-related minor tail protein [Function unknown]; Region: COG5281 1072459005105 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 1072459005106 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 1072459005107 Minor tail protein T; Region: Phage_tail_T; pfam06223 1072459005108 phage minor tail protein G; Region: phage_lambda_G; TIGR01674 1072459005109 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 1072459005110 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 1072459005111 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 1072459005112 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 1072459005113 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 1072459005114 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1072459005115 Transposase; Region: HTH_Tnp_1; cl17663 1072459005116 HTH-like domain; Region: HTH_21; pfam13276 1072459005117 Integrase core domain; Region: rve; pfam00665 1072459005118 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1072459005119 Integrase core domain; Region: rve_3; pfam13683 1072459005120 DNA packaging protein FI; Region: Packaging_FI; pfam14000 1072459005121 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 1072459005122 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 1072459005123 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 1072459005124 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1072459005125 tandem repeat interface [polypeptide binding]; other site 1072459005126 oligomer interface [polypeptide binding]; other site 1072459005127 active site residues [active] 1072459005128 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 1072459005129 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 1072459005130 gpW; Region: gpW; pfam02831 1072459005131 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 1072459005132 Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471 1072459005133 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 1072459005134 GnsA/GnsB family; Region: GnsAB; pfam08178 1072459005135 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 1072459005136 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1072459005137 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1072459005138 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1072459005139 DNA-binding site [nucleotide binding]; DNA binding site 1072459005140 RNA-binding motif; other site 1072459005141 Protein of unknown function (DUF2514); Region: DUF2514; pfam10721 1072459005142 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1072459005143 catalytic residues [active] 1072459005144 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 1072459005145 Lysis protein S; Region: Lysis_S; pfam04971 1072459005146 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1072459005147 DNA-binding site [nucleotide binding]; DNA binding site 1072459005148 RNA-binding motif; other site 1072459005149 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1072459005150 DNA-binding site [nucleotide binding]; DNA binding site 1072459005151 RNA-binding motif; other site 1072459005152 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1072459005153 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1072459005154 DNA-binding interface [nucleotide binding]; DNA binding site 1072459005155 Integrase core domain; Region: rve; pfam00665 1072459005156 transposase/IS protein; Provisional; Region: PRK09183 1072459005157 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1072459005158 Walker A motif; other site 1072459005159 ATP binding site [chemical binding]; other site 1072459005160 Walker B motif; other site 1072459005161 putative transposase OrfB; Reviewed; Region: PHA02517 1072459005162 Integrase core domain; Region: rve; pfam00665 1072459005163 Integrase core domain; Region: rve_3; pfam13683 1072459005164 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1072459005165 Transposase; Region: HTH_Tnp_1; pfam01527 1072459005166 Protein of unknown function (DUF968); Region: DUF968; pfam06147 1072459005167 bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235 1072459005168 putative transposase OrfB; Reviewed; Region: PHA02517 1072459005169 HTH-like domain; Region: HTH_21; pfam13276 1072459005170 Integrase core domain; Region: rve; pfam00665 1072459005171 Integrase core domain; Region: rve_3; pfam13683 1072459005172 putative transposase OrfB; Reviewed; Region: PHA02517 1072459005173 Integrase core domain; Region: rve; pfam00665 1072459005174 Integrase core domain; Region: rve_3; pfam13683 1072459005175 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1072459005176 Transposase; Region: HTH_Tnp_1; pfam01527 1072459005177 Homeodomain-like domain; Region: HTH_23; pfam13384 1072459005178 Winged helix-turn helix; Region: HTH_29; pfam13551 1072459005179 Homeodomain-like domain; Region: HTH_32; pfam13565 1072459005180 Integrase core domain; Region: rve; pfam00665 1072459005181 Integrase core domain; Region: rve_3; cl15866 1072459005182 Methyltransferase domain; Region: Methyltransf_25; pfam13649 1072459005183 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 1072459005184 primosomal protein DnaI; Provisional; Region: PRK02854 1072459005185 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 1072459005186 putative transposase OrfB; Reviewed; Region: PHA02517 1072459005187 HTH-like domain; Region: HTH_21; pfam13276 1072459005188 Integrase core domain; Region: rve; pfam00665 1072459005189 Integrase core domain; Region: rve_3; pfam13683 1072459005190 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 1072459005191 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1072459005192 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 1072459005193 Int/Topo IB signature motif; other site 1072459005194 putative oxidoreductase; Provisional; Region: PRK10083 1072459005195 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 1072459005196 putative NAD(P) binding site [chemical binding]; other site 1072459005197 catalytic Zn binding site [ion binding]; other site 1072459005198 structural Zn binding site [ion binding]; other site 1072459005199 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 1072459005200 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 1072459005201 putative active site pocket [active] 1072459005202 putative metal binding site [ion binding]; other site 1072459005203 hypothetical protein; Provisional; Region: PRK02237 1072459005204 hypothetical protein; Provisional; Region: PRK13659 1072459005205 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 1072459005206 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1072459005207 Coenzyme A binding pocket [chemical binding]; other site 1072459005208 Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788 1072459005209 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 1072459005210 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 1072459005211 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1072459005212 putative [Fe4-S4] binding site [ion binding]; other site 1072459005213 putative molybdopterin cofactor binding site [chemical binding]; other site 1072459005214 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1072459005215 putative molybdopterin cofactor binding site; other site 1072459005216 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 1072459005217 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1072459005218 putative [Fe4-S4] binding site [ion binding]; other site 1072459005219 putative molybdopterin cofactor binding site [chemical binding]; other site 1072459005220 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1072459005221 putative molybdopterin cofactor binding site; other site 1072459005222 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1072459005223 4Fe-4S binding domain; Region: Fer4; cl02805 1072459005224 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 1072459005225 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 1072459005226 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1072459005227 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1072459005228 Cl- selectivity filter; other site 1072459005229 Cl- binding residues [ion binding]; other site 1072459005230 pore gating glutamate residue; other site 1072459005231 dimer interface [polypeptide binding]; other site 1072459005232 putative dithiobiotin synthetase; Provisional; Region: PRK12374 1072459005233 AAA domain; Region: AAA_26; pfam13500 1072459005234 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1072459005235 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1072459005236 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1072459005237 nucleotide binding site [chemical binding]; other site 1072459005238 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1072459005239 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1072459005240 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1072459005241 dimerization interface [polypeptide binding]; other site 1072459005242 substrate binding pocket [chemical binding]; other site 1072459005243 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1072459005244 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459005245 putative substrate translocation pore; other site 1072459005246 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1072459005247 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 1072459005248 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 1072459005249 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 1072459005250 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1072459005251 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 1072459005252 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1072459005253 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 1072459005254 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1072459005255 ligand binding site [chemical binding]; other site 1072459005256 homodimer interface [polypeptide binding]; other site 1072459005257 NAD(P) binding site [chemical binding]; other site 1072459005258 trimer interface B [polypeptide binding]; other site 1072459005259 trimer interface A [polypeptide binding]; other site 1072459005260 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1072459005261 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1072459005262 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1072459005263 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1072459005264 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 1072459005265 Spore germination protein; Region: Spore_permease; cl17796 1072459005266 dihydromonapterin reductase; Provisional; Region: PRK06483 1072459005267 pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357 1072459005268 NADP binding site [chemical binding]; other site 1072459005269 substrate binding pocket [chemical binding]; other site 1072459005270 active site 1072459005271 GlpM protein; Region: GlpM; pfam06942 1072459005272 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 1072459005273 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1072459005274 active site 1072459005275 phosphorylation site [posttranslational modification] 1072459005276 intermolecular recognition site; other site 1072459005277 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1072459005278 DNA binding site [nucleotide binding] 1072459005279 sensor protein RstB; Provisional; Region: PRK10604 1072459005280 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1072459005281 dimerization interface [polypeptide binding]; other site 1072459005282 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1072459005283 dimer interface [polypeptide binding]; other site 1072459005284 phosphorylation site [posttranslational modification] 1072459005285 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1072459005286 ATP binding site [chemical binding]; other site 1072459005287 Mg2+ binding site [ion binding]; other site 1072459005288 G-X-G motif; other site 1072459005289 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 1072459005290 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1072459005291 Class II fumarases; Region: Fumarase_classII; cd01362 1072459005292 active site 1072459005293 tetramer interface [polypeptide binding]; other site 1072459005294 fumarate hydratase; Provisional; Region: PRK15389 1072459005295 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 1072459005296 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1072459005297 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 1072459005298 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1072459005299 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1072459005300 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 1072459005301 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 1072459005302 putative outer membrane porin protein; Provisional; Region: PRK11379 1072459005303 glucuronide transporter; Provisional; Region: PRK09848 1072459005304 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459005305 putative substrate translocation pore; other site 1072459005306 beta-D-glucuronidase; Provisional; Region: PRK10150 1072459005307 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1072459005308 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1072459005309 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1072459005310 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1072459005311 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1072459005312 7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113 1072459005313 7 alpha-hydroxysteroid dehydrogenase (7 alpha-HSDH), classical (c) SDRs; Region: 7_alpha_HSDH_SDR_c; cd05365 1072459005314 NAD binding site [chemical binding]; other site 1072459005315 substrate binding site [chemical binding]; other site 1072459005316 homotetramer interface [polypeptide binding]; other site 1072459005317 homodimer interface [polypeptide binding]; other site 1072459005318 active site 1072459005319 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 1072459005320 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1072459005321 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1072459005322 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 1072459005323 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1072459005324 DNA binding site [nucleotide binding] 1072459005325 domain linker motif; other site 1072459005326 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 1072459005327 putative dimerization interface [polypeptide binding]; other site 1072459005328 putative ligand binding site [chemical binding]; other site 1072459005329 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 1072459005330 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 1072459005331 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1072459005332 active site turn [active] 1072459005333 phosphorylation site [posttranslational modification] 1072459005334 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1072459005335 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1072459005336 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1072459005337 homodimer interface [polypeptide binding]; other site 1072459005338 catalytic residue [active] 1072459005339 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1072459005340 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 1072459005341 active site 1072459005342 purine riboside binding site [chemical binding]; other site 1072459005343 putative oxidoreductase; Provisional; Region: PRK11579 1072459005344 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1072459005345 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1072459005346 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 1072459005347 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 1072459005348 electron transport complex protein RsxA; Provisional; Region: PRK05151 1072459005349 electron transport complex protein RnfB; Provisional; Region: PRK05113 1072459005350 Putative Fe-S cluster; Region: FeS; pfam04060 1072459005351 4Fe-4S binding domain; Region: Fer4; pfam00037 1072459005352 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 1072459005353 SLBB domain; Region: SLBB; pfam10531 1072459005354 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1072459005355 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 1072459005356 electron transport complex protein RnfG; Validated; Region: PRK01908 1072459005357 electron transport complex RsxE subunit; Provisional; Region: PRK12405 1072459005358 endonuclease III; Provisional; Region: PRK10702 1072459005359 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1072459005360 minor groove reading motif; other site 1072459005361 helix-hairpin-helix signature motif; other site 1072459005362 substrate binding pocket [chemical binding]; other site 1072459005363 active site 1072459005364 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1072459005365 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1072459005366 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459005367 putative substrate translocation pore; other site 1072459005368 POT family; Region: PTR2; pfam00854 1072459005369 glutathionine S-transferase; Provisional; Region: PRK10542 1072459005370 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1072459005371 C-terminal domain interface [polypeptide binding]; other site 1072459005372 GSH binding site (G-site) [chemical binding]; other site 1072459005373 dimer interface [polypeptide binding]; other site 1072459005374 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1072459005375 N-terminal domain interface [polypeptide binding]; other site 1072459005376 dimer interface [polypeptide binding]; other site 1072459005377 substrate binding pocket (H-site) [chemical binding]; other site 1072459005378 pyridoxamine kinase; Validated; Region: PRK05756 1072459005379 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1072459005380 dimer interface [polypeptide binding]; other site 1072459005381 pyridoxal binding site [chemical binding]; other site 1072459005382 ATP binding site [chemical binding]; other site 1072459005383 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1072459005384 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1072459005385 active site 1072459005386 HIGH motif; other site 1072459005387 dimer interface [polypeptide binding]; other site 1072459005388 KMSKS motif; other site 1072459005389 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1072459005390 RNA binding surface [nucleotide binding]; other site 1072459005391 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 1072459005392 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1072459005393 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1072459005394 lysozyme inhibitor; Provisional; Region: PRK11372 1072459005395 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 1072459005396 Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702 1072459005397 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 1072459005398 transcriptional regulator SlyA; Provisional; Region: PRK03573 1072459005399 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1072459005400 Protein of unknown function (DUF1656); Region: DUF1656; cl11658 1072459005401 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1072459005402 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1072459005403 HlyD family secretion protein; Region: HlyD_3; pfam13437 1072459005404 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1072459005405 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1072459005406 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1072459005407 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1072459005408 E-class dimer interface [polypeptide binding]; other site 1072459005409 P-class dimer interface [polypeptide binding]; other site 1072459005410 active site 1072459005411 Cu2+ binding site [ion binding]; other site 1072459005412 Zn2+ binding site [ion binding]; other site 1072459005413 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1072459005414 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1072459005415 active site 1072459005416 catalytic tetrad [active] 1072459005417 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1072459005418 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1072459005419 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1072459005420 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1072459005421 dimer interface [polypeptide binding]; other site 1072459005422 active site 1072459005423 metal binding site [ion binding]; metal-binding site 1072459005424 glutathione binding site [chemical binding]; other site 1072459005425 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1072459005426 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 1072459005427 dimer interface [polypeptide binding]; other site 1072459005428 catalytic site [active] 1072459005429 putative active site [active] 1072459005430 putative substrate binding site [chemical binding]; other site 1072459005431 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1072459005432 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 1072459005433 ATP binding site [chemical binding]; other site 1072459005434 putative Mg++ binding site [ion binding]; other site 1072459005435 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1072459005436 nucleotide binding region [chemical binding]; other site 1072459005437 ATP-binding site [chemical binding]; other site 1072459005438 DEAD/H associated; Region: DEAD_assoc; pfam08494 1072459005439 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1072459005440 putative GSH binding site [chemical binding]; other site 1072459005441 catalytic residues [active] 1072459005442 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1072459005443 NlpC/P60 family; Region: NLPC_P60; pfam00877 1072459005444 superoxide dismutase; Provisional; Region: PRK10543 1072459005445 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1072459005446 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1072459005447 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459005448 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1072459005449 putative substrate translocation pore; other site 1072459005450 hypothetical protein; Provisional; Region: PRK14756 1072459005451 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 1072459005452 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1072459005453 DNA binding site [nucleotide binding] 1072459005454 domain linker motif; other site 1072459005455 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 1072459005456 dimerization interface [polypeptide binding]; other site 1072459005457 ligand binding site [chemical binding]; other site 1072459005458 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1072459005459 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1072459005460 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1072459005461 dimerization interface [polypeptide binding]; other site 1072459005462 putative transporter; Provisional; Region: PRK11043 1072459005463 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459005464 putative substrate translocation pore; other site 1072459005465 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 1072459005466 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1072459005467 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1072459005468 S-adenosylmethionine binding site [chemical binding]; other site 1072459005469 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 1072459005470 Lumazine binding domain; Region: Lum_binding; pfam00677 1072459005471 Lumazine binding domain; Region: Lum_binding; pfam00677 1072459005472 multidrug efflux protein; Reviewed; Region: PRK01766 1072459005473 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1072459005474 cation binding site [ion binding]; other site 1072459005475 hypothetical protein; Provisional; Region: PRK09945 1072459005476 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 1072459005477 putative monooxygenase; Provisional; Region: PRK11118 1072459005478 hypothetical protein; Provisional; Region: PRK09897 1072459005479 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1072459005480 hypothetical protein; Provisional; Region: PRK09946 1072459005481 thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006 1072459005482 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 1072459005483 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 1072459005484 hypothetical protein; Provisional; Region: PRK09947 1072459005485 putative oxidoreductase; Provisional; Region: PRK09849 1072459005486 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 1072459005487 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 1072459005488 hypothetical protein; Provisional; Region: PRK09898 1072459005489 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1072459005490 hypothetical protein; Provisional; Region: PRK10292 1072459005491 pyruvate kinase; Provisional; Region: PRK09206 1072459005492 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 1072459005493 domain interfaces; other site 1072459005494 active site 1072459005495 murein lipoprotein; Provisional; Region: PRK15396 1072459005496 L,D-transpeptidase; Provisional; Region: PRK10190 1072459005497 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1072459005498 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1072459005499 cysteine desufuration protein SufE; Provisional; Region: PRK09296 1072459005500 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1072459005501 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1072459005502 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1072459005503 catalytic residue [active] 1072459005504 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 1072459005505 FeS assembly protein SufD; Region: sufD; TIGR01981 1072459005506 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 1072459005507 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1072459005508 Walker A/P-loop; other site 1072459005509 ATP binding site [chemical binding]; other site 1072459005510 Q-loop/lid; other site 1072459005511 ABC transporter signature motif; other site 1072459005512 Walker B; other site 1072459005513 D-loop; other site 1072459005514 H-loop/switch region; other site 1072459005515 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 1072459005516 putative ABC transporter; Region: ycf24; CHL00085 1072459005517 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 1072459005518 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1072459005519 CoenzymeA binding site [chemical binding]; other site 1072459005520 subunit interaction site [polypeptide binding]; other site 1072459005521 PHB binding site; other site 1072459005522 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1072459005523 FAD binding domain; Region: FAD_binding_4; pfam01565 1072459005524 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1072459005525 putative inner membrane protein; Provisional; Region: PRK10983 1072459005526 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1072459005527 Domain of unknown function (DUF1870); Region: DUF1870; pfam08965 1072459005528 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459005529 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1072459005530 putative substrate translocation pore; other site 1072459005531 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459005532 putative substrate translocation pore; other site 1072459005533 quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749 1072459005534 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1072459005535 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1072459005536 shikimate binding site; other site 1072459005537 NAD(P) binding site [chemical binding]; other site 1072459005538 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 1072459005539 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1072459005540 active site 1072459005541 catalytic residue [active] 1072459005542 dimer interface [polypeptide binding]; other site 1072459005543 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 1072459005544 Coenzyme A transferase; Region: CoA_trans; smart00882 1072459005545 Coenzyme A transferase; Region: CoA_trans; cl17247 1072459005546 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 1072459005547 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1072459005548 active site 1072459005549 Cupin domain; Region: Cupin_2; pfam07883 1072459005550 Winged helix DNA-binding domain (DUF1495); Region: DUF1495; cl01336 1072459005551 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1072459005552 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1072459005553 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1072459005554 Ligand binding site [chemical binding]; other site 1072459005555 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1072459005556 electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916 1072459005557 Electron transfer flavoprotein domain; Region: ETF; smart00893 1072459005558 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1072459005559 oxidoreductase; Provisional; Region: PRK10015 1072459005560 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 1072459005561 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 1072459005562 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 1072459005563 acyl-activating enzyme (AAE) consensus motif; other site 1072459005564 putative AMP binding site [chemical binding]; other site 1072459005565 putative active site [active] 1072459005566 putative CoA binding site [chemical binding]; other site 1072459005567 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1072459005568 classical (c) SDRs; Region: SDR_c; cd05233 1072459005569 NAD(P) binding site [chemical binding]; other site 1072459005570 active site 1072459005571 Domain of unknown function (DUF386); Region: DUF386; cl01047 1072459005572 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1072459005573 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 1072459005574 putative ligand binding site [chemical binding]; other site 1072459005575 NAD binding site [chemical binding]; other site 1072459005576 catalytic site [active] 1072459005577 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1072459005578 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1072459005579 transmembrane helices; other site 1072459005580 phosphoenolpyruvate synthase; Validated; Region: PRK06464 1072459005581 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1072459005582 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1072459005583 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1072459005584 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1072459005585 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 1072459005586 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1072459005587 Hemin uptake protein [Inorganic ion transport and metabolism]; Region: HemP; COG4256 1072459005588 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1072459005589 hypothetical protein; Validated; Region: PRK00029 1072459005590 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 1072459005591 NlpC/P60 family; Region: NLPC_P60; pfam00877 1072459005592 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 1072459005593 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1072459005594 Walker A/P-loop; other site 1072459005595 ATP binding site [chemical binding]; other site 1072459005596 Q-loop/lid; other site 1072459005597 ABC transporter signature motif; other site 1072459005598 Walker B; other site 1072459005599 D-loop; other site 1072459005600 H-loop/switch region; other site 1072459005601 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1072459005602 catalytic residues [active] 1072459005603 dimer interface [polypeptide binding]; other site 1072459005604 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1072459005605 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1072459005606 ABC-ATPase subunit interface; other site 1072459005607 dimer interface [polypeptide binding]; other site 1072459005608 putative PBP binding regions; other site 1072459005609 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1072459005610 IHF dimer interface [polypeptide binding]; other site 1072459005611 IHF - DNA interface [nucleotide binding]; other site 1072459005612 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1072459005613 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1072459005614 putative tRNA-binding site [nucleotide binding]; other site 1072459005615 B3/4 domain; Region: B3_4; pfam03483 1072459005616 tRNA synthetase B5 domain; Region: B5; smart00874 1072459005617 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1072459005618 dimer interface [polypeptide binding]; other site 1072459005619 motif 1; other site 1072459005620 motif 3; other site 1072459005621 motif 2; other site 1072459005622 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1072459005623 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1072459005624 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1072459005625 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1072459005626 dimer interface [polypeptide binding]; other site 1072459005627 motif 1; other site 1072459005628 active site 1072459005629 motif 2; other site 1072459005630 motif 3; other site 1072459005631 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1072459005632 23S rRNA binding site [nucleotide binding]; other site 1072459005633 L21 binding site [polypeptide binding]; other site 1072459005634 L13 binding site [polypeptide binding]; other site 1072459005635 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1072459005636 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1072459005637 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1072459005638 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1072459005639 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1072459005640 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1072459005641 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1072459005642 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1072459005643 active site 1072459005644 dimer interface [polypeptide binding]; other site 1072459005645 motif 1; other site 1072459005646 motif 2; other site 1072459005647 motif 3; other site 1072459005648 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1072459005649 anticodon binding site; other site 1072459005650 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 1072459005651 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 1072459005652 6-phosphofructokinase 2; Provisional; Region: PRK10294 1072459005653 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1072459005654 putative substrate binding site [chemical binding]; other site 1072459005655 putative ATP binding site [chemical binding]; other site 1072459005656 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 1072459005657 Phosphotransferase enzyme family; Region: APH; pfam01636 1072459005658 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1072459005659 active site 1072459005660 ATP binding site [chemical binding]; other site 1072459005661 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1072459005662 YniB-like protein; Region: YniB; pfam14002 1072459005663 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 1072459005664 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1072459005665 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1072459005666 motif II; other site 1072459005667 inner membrane protein; Provisional; Region: PRK11648 1072459005668 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1072459005669 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1072459005670 cell division modulator; Provisional; Region: PRK10113 1072459005671 hydroperoxidase II; Provisional; Region: katE; PRK11249 1072459005672 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 1072459005673 tetramer interface [polypeptide binding]; other site 1072459005674 heme binding pocket [chemical binding]; other site 1072459005675 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1072459005676 domain interactions; other site 1072459005677 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1072459005678 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1072459005679 NAD binding site [chemical binding]; other site 1072459005680 sugar binding site [chemical binding]; other site 1072459005681 divalent metal binding site [ion binding]; other site 1072459005682 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1072459005683 dimer interface [polypeptide binding]; other site 1072459005684 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 1072459005685 Cupin domain; Region: Cupin_2; pfam07883 1072459005686 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1072459005687 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1072459005688 methionine cluster; other site 1072459005689 active site 1072459005690 phosphorylation site [posttranslational modification] 1072459005691 metal binding site [ion binding]; metal-binding site 1072459005692 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 1072459005693 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1072459005694 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1072459005695 active site 1072459005696 P-loop; other site 1072459005697 phosphorylation site [posttranslational modification] 1072459005698 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 1072459005699 NAD+ synthetase; Region: nadE; TIGR00552 1072459005700 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1072459005701 homodimer interface [polypeptide binding]; other site 1072459005702 NAD binding pocket [chemical binding]; other site 1072459005703 ATP binding pocket [chemical binding]; other site 1072459005704 Mg binding site [ion binding]; other site 1072459005705 active-site loop [active] 1072459005706 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 1072459005707 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1072459005708 GIY-YIG motif/motif A; other site 1072459005709 active site 1072459005710 catalytic site [active] 1072459005711 putative DNA binding site [nucleotide binding]; other site 1072459005712 metal binding site [ion binding]; metal-binding site 1072459005713 hypothetical protein; Provisional; Region: PRK11396 1072459005714 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1072459005715 dimer interface [polypeptide binding]; other site 1072459005716 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 1072459005717 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 1072459005718 putative active site [active] 1072459005719 Zn binding site [ion binding]; other site 1072459005720 succinylarginine dihydrolase; Provisional; Region: PRK13281 1072459005721 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 1072459005722 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 1072459005723 NAD(P) binding site [chemical binding]; other site 1072459005724 catalytic residues [active] 1072459005725 arginine succinyltransferase; Provisional; Region: PRK10456 1072459005726 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 1072459005727 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 1072459005728 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1072459005729 inhibitor-cofactor binding pocket; inhibition site 1072459005730 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1072459005731 catalytic residue [active] 1072459005732 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1072459005733 putative catalytic site [active] 1072459005734 putative phosphate binding site [ion binding]; other site 1072459005735 active site 1072459005736 metal binding site A [ion binding]; metal-binding site 1072459005737 DNA binding site [nucleotide binding] 1072459005738 putative AP binding site [nucleotide binding]; other site 1072459005739 putative metal binding site B [ion binding]; other site 1072459005740 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1072459005741 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1072459005742 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1072459005743 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1072459005744 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1072459005745 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1072459005746 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 1072459005747 hypothetical protein; Provisional; Region: PRK11622 1072459005748 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135 1072459005749 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1072459005750 dimer interface [polypeptide binding]; other site 1072459005751 conserved gate region; other site 1072459005752 putative PBP binding loops; other site 1072459005753 ABC-ATPase subunit interface; other site 1072459005754 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 1072459005755 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1072459005756 Walker A/P-loop; other site 1072459005757 ATP binding site [chemical binding]; other site 1072459005758 Q-loop/lid; other site 1072459005759 ABC transporter signature motif; other site 1072459005760 Walker B; other site 1072459005761 D-loop; other site 1072459005762 H-loop/switch region; other site 1072459005763 Rhodanese Homology Domain; Region: RHOD; smart00450 1072459005764 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1072459005765 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1072459005766 active site residue [active] 1072459005767 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1072459005768 active site residue [active] 1072459005769 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1072459005770 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1072459005771 active site 1072459005772 8-oxo-dGMP binding site [chemical binding]; other site 1072459005773 nudix motif; other site 1072459005774 metal binding site [ion binding]; metal-binding site 1072459005775 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 1072459005776 glutamate dehydrogenase; Provisional; Region: PRK09414 1072459005777 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1072459005778 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1072459005779 NAD(P) binding site [chemical binding]; other site 1072459005780 DNA topoisomerase III; Provisional; Region: PRK07726 1072459005781 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1072459005782 active site 1072459005783 putative interdomain interaction site [polypeptide binding]; other site 1072459005784 putative metal-binding site [ion binding]; other site 1072459005785 putative nucleotide binding site [chemical binding]; other site 1072459005786 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1072459005787 domain I; other site 1072459005788 DNA binding groove [nucleotide binding] 1072459005789 phosphate binding site [ion binding]; other site 1072459005790 domain II; other site 1072459005791 domain III; other site 1072459005792 nucleotide binding site [chemical binding]; other site 1072459005793 catalytic site [active] 1072459005794 domain IV; other site 1072459005795 selenophosphate synthetase; Provisional; Region: PRK00943 1072459005796 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 1072459005797 dimerization interface [polypeptide binding]; other site 1072459005798 putative ATP binding site [chemical binding]; other site 1072459005799 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1072459005800 putative FMN binding site [chemical binding]; other site 1072459005801 protease 4; Provisional; Region: PRK10949 1072459005802 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 1072459005803 tandem repeat interface [polypeptide binding]; other site 1072459005804 oligomer interface [polypeptide binding]; other site 1072459005805 active site residues [active] 1072459005806 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 1072459005807 tandem repeat interface [polypeptide binding]; other site 1072459005808 oligomer interface [polypeptide binding]; other site 1072459005809 active site residues [active] 1072459005810 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1072459005811 active site 1072459005812 homodimer interface [polypeptide binding]; other site 1072459005813 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1072459005814 Isochorismatase family; Region: Isochorismatase; pfam00857 1072459005815 catalytic triad [active] 1072459005816 metal binding site [ion binding]; metal-binding site 1072459005817 conserved cis-peptide bond; other site 1072459005818 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1072459005819 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459005820 putative substrate translocation pore; other site 1072459005821 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459005822 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1072459005823 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1072459005824 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1072459005825 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1072459005826 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1072459005827 active site 1072459005828 catalytic tetrad [active] 1072459005829 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1072459005830 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1072459005831 substrate binding site [chemical binding]; other site 1072459005832 ATP binding site [chemical binding]; other site 1072459005833 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1072459005834 intersubunit interface [polypeptide binding]; other site 1072459005835 active site 1072459005836 zinc binding site [ion binding]; other site 1072459005837 Na+ binding site [ion binding]; other site 1072459005838 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1072459005839 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 1072459005840 inhibitor binding site; inhibition site 1072459005841 catalytic Zn binding site [ion binding]; other site 1072459005842 structural Zn binding site [ion binding]; other site 1072459005843 NADP binding site [chemical binding]; other site 1072459005844 tetramer interface [polypeptide binding]; other site 1072459005845 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459005846 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459005847 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1072459005848 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 1072459005849 putative NAD(P) binding site [chemical binding]; other site 1072459005850 catalytic Zn binding site [ion binding]; other site 1072459005851 structural Zn binding site [ion binding]; other site 1072459005852 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 1072459005853 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1072459005854 SelR domain; Region: SelR; pfam01641 1072459005855 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 1072459005856 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1072459005857 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1072459005858 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 1072459005859 active site 1072459005860 phosphate binding residues; other site 1072459005861 catalytic residues [active] 1072459005862 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1072459005863 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1072459005864 active site 1072459005865 catalytic tetrad [active] 1072459005866 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 1072459005867 PrkA family serine protein kinase; Provisional; Region: PRK15455 1072459005868 AAA ATPase domain; Region: AAA_16; pfam13191 1072459005869 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1072459005870 hypothetical protein; Provisional; Region: PRK05325 1072459005871 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1072459005872 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1072459005873 metal binding site [ion binding]; metal-binding site 1072459005874 active site 1072459005875 I-site; other site 1072459005876 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1072459005877 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1072459005878 metal binding site [ion binding]; metal-binding site 1072459005879 active site 1072459005880 I-site; other site 1072459005881 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 1072459005882 putative deacylase active site [active] 1072459005883 Predicted membrane protein [Function unknown]; Region: COG2707 1072459005884 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1072459005885 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1072459005886 cyanate transporter; Region: CynX; TIGR00896 1072459005887 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459005888 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1072459005889 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 1072459005890 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1072459005891 Domain of unknown function (DUF333); Region: DUF333; pfam03891 1072459005892 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1072459005893 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1072459005894 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1072459005895 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1072459005896 metal binding site [ion binding]; metal-binding site 1072459005897 active site 1072459005898 I-site; other site 1072459005899 hypothetical protein; Provisional; Region: PRK10457 1072459005900 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 1072459005901 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 1072459005902 leucine export protein LeuE; Provisional; Region: PRK10958 1072459005903 transcriptional activator TtdR; Provisional; Region: PRK09801 1072459005904 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1072459005905 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 1072459005906 putative effector binding pocket; other site 1072459005907 putative dimerization interface [polypeptide binding]; other site 1072459005908 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1072459005909 tartrate dehydrogenase; Region: TTC; TIGR02089 1072459005910 putative transporter; Provisional; Region: PRK09950 1072459005911 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1072459005912 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1072459005913 [2Fe-2S] cluster binding site [ion binding]; other site 1072459005914 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_2; cd08886 1072459005915 putative alpha subunit interface [polypeptide binding]; other site 1072459005916 putative active site [active] 1072459005917 putative substrate binding site [chemical binding]; other site 1072459005918 Fe binding site [ion binding]; other site 1072459005919 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1072459005920 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1072459005921 FMN-binding pocket [chemical binding]; other site 1072459005922 flavin binding motif; other site 1072459005923 phosphate binding motif [ion binding]; other site 1072459005924 beta-alpha-beta structure motif; other site 1072459005925 NAD binding pocket [chemical binding]; other site 1072459005926 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1072459005927 catalytic loop [active] 1072459005928 iron binding site [ion binding]; other site 1072459005929 ribonuclease D; Provisional; Region: PRK10829 1072459005930 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1072459005931 catalytic site [active] 1072459005932 putative active site [active] 1072459005933 putative substrate binding site [chemical binding]; other site 1072459005934 Helicase and RNase D C-terminal; Region: HRDC; smart00341 1072459005935 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 1072459005936 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1072459005937 acyl-activating enzyme (AAE) consensus motif; other site 1072459005938 putative AMP binding site [chemical binding]; other site 1072459005939 putative active site [active] 1072459005940 putative CoA binding site [chemical binding]; other site 1072459005941 Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065 1072459005942 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 1072459005943 Glycoprotease family; Region: Peptidase_M22; pfam00814 1072459005944 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1072459005945 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1072459005946 DEAD_2; Region: DEAD_2; pfam06733 1072459005947 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1072459005948 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 1072459005949 homotrimer interaction site [polypeptide binding]; other site 1072459005950 putative active site [active] 1072459005951 Domain of unknown function (DUF1889); Region: DUF1889; pfam08986 1072459005952 hypothetical protein; Provisional; Region: PRK05114 1072459005953 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 1072459005954 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1072459005955 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 1072459005956 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1072459005957 putative active site [active] 1072459005958 putative CoA binding site [chemical binding]; other site 1072459005959 nudix motif; other site 1072459005960 metal binding site [ion binding]; metal-binding site 1072459005961 L-serine deaminase; Provisional; Region: PRK15023 1072459005962 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1072459005963 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1072459005964 phage resistance protein; Provisional; Region: PRK10551 1072459005965 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1072459005966 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1072459005967 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1072459005968 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1072459005969 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1072459005970 Transporter associated domain; Region: CorC_HlyC; smart01091 1072459005971 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 1072459005972 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1072459005973 active pocket/dimerization site; other site 1072459005974 active site 1072459005975 phosphorylation site [posttranslational modification] 1072459005976 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1072459005977 active site 1072459005978 phosphorylation site [posttranslational modification] 1072459005979 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 1072459005980 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 1072459005981 Predicted membrane protein [Function unknown]; Region: COG4811 1072459005982 hypothetical protein; Provisional; Region: PRK11469 1072459005983 Domain of unknown function DUF; Region: DUF204; pfam02659 1072459005984 Domain of unknown function DUF; Region: DUF204; pfam02659 1072459005985 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1072459005986 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1072459005987 S-adenosylmethionine binding site [chemical binding]; other site 1072459005988 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1072459005989 DNA-binding site [nucleotide binding]; DNA binding site 1072459005990 RNA-binding motif; other site 1072459005991 Protein of unknown function (DUF2627); Region: DUF2527; pfam10736 1072459005992 YebO-like protein; Region: YebO; pfam13974 1072459005993 PhoPQ regulatory protein; Provisional; Region: PRK10299 1072459005994 YobH-like protein; Region: YobH; pfam13996 1072459005995 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 1072459005996 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1072459005997 dimerization interface [polypeptide binding]; other site 1072459005998 putative Zn2+ binding site [ion binding]; other site 1072459005999 putative DNA binding site [nucleotide binding]; other site 1072459006000 Bacterial transcriptional regulator; Region: IclR; pfam01614 1072459006001 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459006002 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1072459006003 putative substrate translocation pore; other site 1072459006004 heat shock protein HtpX; Provisional; Region: PRK05457 1072459006005 carboxy-terminal protease; Provisional; Region: PRK11186 1072459006006 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1072459006007 protein binding site [polypeptide binding]; other site 1072459006008 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1072459006009 Catalytic dyad [active] 1072459006010 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 1072459006011 ProP expression regulator; Provisional; Region: PRK04950 1072459006012 ProQ/FINO family; Region: ProQ; pfam04352 1072459006013 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1072459006014 GAF domain; Region: GAF_2; pfam13185 1072459006015 integral membrane protein, PqiA family; Region: pqiA_fam; TIGR00155 1072459006016 Paraquat-inducible protein A; Region: PqiA; pfam04403 1072459006017 Paraquat-inducible protein A; Region: PqiA; pfam04403 1072459006018 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 1072459006019 mce related protein; Region: MCE; pfam02470 1072459006020 mce related protein; Region: MCE; pfam02470 1072459006021 mce related protein; Region: MCE; pfam02470 1072459006022 mce related protein; Region: MCE; pfam02470 1072459006023 mce related protein; Region: MCE; pfam02470 1072459006024 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 1072459006025 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1072459006026 S-adenosylmethionine binding site [chemical binding]; other site 1072459006027 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 1072459006028 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 1072459006029 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 1072459006030 serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439 1072459006031 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1072459006032 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 1072459006033 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 1072459006034 hypothetical protein; Provisional; Region: PRK10301 1072459006035 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 1072459006036 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1072459006037 Carbon-nitrogen hydrolase; Region: CN_hydrolase; pfam00795 1072459006038 exodeoxyribonuclease X; Provisional; Region: PRK07983 1072459006039 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1072459006040 active site 1072459006041 catalytic site [active] 1072459006042 substrate binding site [chemical binding]; other site 1072459006043 protease 2; Provisional; Region: PRK10115 1072459006044 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1072459006045 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 1072459006046 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 1072459006047 putative metal binding site [ion binding]; other site 1072459006048 hypothetical protein; Provisional; Region: PRK13680 1072459006049 DNA damage-inducible protein YebG; Provisional; Region: PRK10061 1072459006050 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1072459006051 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1072459006052 ATP-grasp domain; Region: ATP-grasp; pfam02222 1072459006053 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 1072459006054 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1072459006055 active site 1072459006056 intersubunit interface [polypeptide binding]; other site 1072459006057 catalytic residue [active] 1072459006058 phosphogluconate dehydratase; Validated; Region: PRK09054 1072459006059 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1072459006060 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1072459006061 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1072459006062 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1072459006063 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 1072459006064 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1072459006065 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1072459006066 putative active site [active] 1072459006067 pyruvate kinase; Provisional; Region: PRK05826 1072459006068 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 1072459006069 domain interfaces; other site 1072459006070 active site 1072459006071 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1072459006072 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1072459006073 putative acyl-acceptor binding pocket; other site 1072459006074 putative peptidase; Provisional; Region: PRK11649 1072459006075 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 1072459006076 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1072459006077 Peptidase family M23; Region: Peptidase_M23; pfam01551 1072459006078 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 1072459006079 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 1072459006080 metal binding site [ion binding]; metal-binding site 1072459006081 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 1072459006082 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1072459006083 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1072459006084 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1072459006085 ABC-ATPase subunit interface; other site 1072459006086 dimer interface [polypeptide binding]; other site 1072459006087 putative PBP binding regions; other site 1072459006088 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1072459006089 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1072459006090 Walker A motif; other site 1072459006091 ATP binding site [chemical binding]; other site 1072459006092 Walker B motif; other site 1072459006093 arginine finger; other site 1072459006094 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1072459006095 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1072459006096 RuvA N terminal domain; Region: RuvA_N; pfam01330 1072459006097 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1072459006098 hypothetical protein; Provisional; Region: PRK11470 1072459006099 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1072459006100 active site 1072459006101 putative DNA-binding cleft [nucleotide binding]; other site 1072459006102 dimer interface [polypeptide binding]; other site 1072459006103 hypothetical protein; Validated; Region: PRK00110 1072459006104 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 1072459006105 nudix motif; other site 1072459006106 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1072459006107 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1072459006108 dimer interface [polypeptide binding]; other site 1072459006109 anticodon binding site; other site 1072459006110 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1072459006111 homodimer interface [polypeptide binding]; other site 1072459006112 motif 1; other site 1072459006113 active site 1072459006114 motif 2; other site 1072459006115 GAD domain; Region: GAD; pfam02938 1072459006116 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1072459006117 active site 1072459006118 motif 3; other site 1072459006119 Isochorismatase family; Region: Isochorismatase; pfam00857 1072459006120 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1072459006121 catalytic triad [active] 1072459006122 conserved cis-peptide bond; other site 1072459006123 hypothetical protein; Provisional; Region: PRK10302 1072459006124 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 1072459006125 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1072459006126 S-adenosylmethionine binding site [chemical binding]; other site 1072459006127 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1072459006128 S-adenosylmethionine binding site [chemical binding]; other site 1072459006129 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 1072459006130 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1072459006131 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 1072459006132 molybdopterin cofactor binding site [chemical binding]; other site 1072459006133 substrate binding site [chemical binding]; other site 1072459006134 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 1072459006135 molybdopterin cofactor binding site; other site 1072459006136 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 1072459006137 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 1072459006138 copper homeostasis protein CutC; Provisional; Region: PRK11572 1072459006139 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 1072459006140 putative metal binding site [ion binding]; other site 1072459006141 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1072459006142 arginyl-tRNA synthetase; Region: argS; TIGR00456 1072459006143 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1072459006144 active site 1072459006145 HIGH motif; other site 1072459006146 KMSK motif region; other site 1072459006147 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1072459006148 tRNA binding surface [nucleotide binding]; other site 1072459006149 anticodon binding site; other site 1072459006150 Flagellar protein FlhE; Region: FlhE; pfam06366 1072459006151 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1072459006152 FHIPEP family; Region: FHIPEP; pfam00771 1072459006153 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1072459006154 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1072459006155 chemotaxis regulator CheZ; Provisional; Region: PRK11166 1072459006156 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 1072459006157 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1072459006158 active site 1072459006159 phosphorylation site [posttranslational modification] 1072459006160 intermolecular recognition site; other site 1072459006161 dimerization interface [polypeptide binding]; other site 1072459006162 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1072459006163 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1072459006164 active site 1072459006165 phosphorylation site [posttranslational modification] 1072459006166 intermolecular recognition site; other site 1072459006167 dimerization interface [polypeptide binding]; other site 1072459006168 CheB methylesterase; Region: CheB_methylest; pfam01339 1072459006169 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 1072459006170 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1072459006171 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1072459006172 S-adenosylmethionine binding site [chemical binding]; other site 1072459006173 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 1072459006174 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1072459006175 dimer interface [polypeptide binding]; other site 1072459006176 ligand binding site [chemical binding]; other site 1072459006177 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1072459006178 dimerization interface [polypeptide binding]; other site 1072459006179 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1072459006180 dimer interface [polypeptide binding]; other site 1072459006181 putative CheW interface [polypeptide binding]; other site 1072459006182 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1072459006183 putative CheA interaction surface; other site 1072459006184 chemotaxis protein CheA; Provisional; Region: PRK10547 1072459006185 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1072459006186 putative binding surface; other site 1072459006187 active site 1072459006188 CheY binding; Region: CheY-binding; pfam09078 1072459006189 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1072459006190 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1072459006191 ATP binding site [chemical binding]; other site 1072459006192 Mg2+ binding site [ion binding]; other site 1072459006193 G-X-G motif; other site 1072459006194 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1072459006195 flagellar motor protein MotB; Validated; Region: motB; PRK09041 1072459006196 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1072459006197 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1072459006198 ligand binding site [chemical binding]; other site 1072459006199 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1072459006200 flagellar motor protein MotA; Validated; Region: PRK09110 1072459006201 transcriptional activator FlhC; Provisional; Region: PRK12722 1072459006202 transcriptional activator FlhD; Provisional; Region: PRK02909 1072459006203 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1072459006204 Ligand Binding Site [chemical binding]; other site 1072459006205 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 1072459006206 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1072459006207 active site 1072459006208 homotetramer interface [polypeptide binding]; other site 1072459006209 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187 1072459006210 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 1072459006211 putative transposase OrfB; Reviewed; Region: PHA02517 1072459006212 HTH-like domain; Region: HTH_21; pfam13276 1072459006213 Integrase core domain; Region: rve; pfam00665 1072459006214 Integrase core domain; Region: rve_3; pfam13683 1072459006215 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 1072459006216 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1072459006217 Walker A/P-loop; other site 1072459006218 ATP binding site [chemical binding]; other site 1072459006219 Q-loop/lid; other site 1072459006220 ABC transporter signature motif; other site 1072459006221 Walker B; other site 1072459006222 D-loop; other site 1072459006223 H-loop/switch region; other site 1072459006224 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1072459006225 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 1072459006226 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 1072459006227 ligand binding site [chemical binding]; other site 1072459006228 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1072459006229 Ferritin-like domain; Region: Ferritin; pfam00210 1072459006230 ferroxidase diiron center [ion binding]; other site 1072459006231 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 1072459006232 YecR-like lipoprotein; Region: YecR; pfam13992 1072459006233 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1072459006234 Ferritin-like domain; Region: Ferritin; pfam00210 1072459006235 ferroxidase diiron center [ion binding]; other site 1072459006236 probable metal-binding protein; Region: matur_matur; TIGR03853 1072459006237 tyrosine transporter TyrP; Provisional; Region: PRK15132 1072459006238 aromatic amino acid transport protein; Region: araaP; TIGR00837 1072459006239 hypothetical protein; Provisional; Region: PRK10396 1072459006240 yecA family protein; Region: ygfB_yecA; TIGR02292 1072459006241 SEC-C motif; Region: SEC-C; pfam02810 1072459006242 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 1072459006243 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1072459006244 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1072459006245 GIY-YIG motif/motif A; other site 1072459006246 active site 1072459006247 catalytic site [active] 1072459006248 putative DNA binding site [nucleotide binding]; other site 1072459006249 metal binding site [ion binding]; metal-binding site 1072459006250 UvrB/uvrC motif; Region: UVR; pfam02151 1072459006251 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1072459006252 Helix-hairpin-helix motif; Region: HHH; pfam00633 1072459006253 response regulator; Provisional; Region: PRK09483 1072459006254 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1072459006255 active site 1072459006256 phosphorylation site [posttranslational modification] 1072459006257 intermolecular recognition site; other site 1072459006258 dimerization interface [polypeptide binding]; other site 1072459006259 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1072459006260 DNA binding residues [nucleotide binding] 1072459006261 dimerization interface [polypeptide binding]; other site 1072459006262 hypothetical protein; Provisional; Region: PRK10613 1072459006263 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 1072459006264 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1072459006265 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1072459006266 DNA binding residues [nucleotide binding] 1072459006267 dimerization interface [polypeptide binding]; other site 1072459006268 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 1072459006269 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1072459006270 Walker A/P-loop; other site 1072459006271 ATP binding site [chemical binding]; other site 1072459006272 Q-loop/lid; other site 1072459006273 ABC transporter signature motif; other site 1072459006274 Walker B; other site 1072459006275 D-loop; other site 1072459006276 H-loop/switch region; other site 1072459006277 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1072459006278 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1072459006279 dimer interface [polypeptide binding]; other site 1072459006280 conserved gate region; other site 1072459006281 putative PBP binding loops; other site 1072459006282 ABC-ATPase subunit interface; other site 1072459006283 D-cysteine desulfhydrase; Validated; Region: PRK03910 1072459006284 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 1072459006285 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1072459006286 catalytic residue [active] 1072459006287 cystine transporter subunit; Provisional; Region: PRK11260 1072459006288 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1072459006289 substrate binding pocket [chemical binding]; other site 1072459006290 membrane-bound complex binding site; other site 1072459006291 hinge residues; other site 1072459006292 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 1072459006293 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 1072459006294 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1072459006295 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1072459006296 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1072459006297 DNA binding residues [nucleotide binding] 1072459006298 flagellin; Validated; Region: PRK08026 1072459006299 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1072459006300 Flagellin protein; Region: FliC; pfam12445 1072459006301 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1072459006302 flagellar capping protein; Reviewed; Region: fliD; PRK08032 1072459006303 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1072459006304 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1072459006305 Flagellar protein FliS; Region: FliS; cl00654 1072459006306 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 1072459006307 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 1072459006308 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 1072459006309 active site 1072459006310 Na/Ca binding site [ion binding]; other site 1072459006311 catalytic site [active] 1072459006312 lipoprotein; Provisional; Region: PRK10397 1072459006313 putative inner membrane protein; Provisional; Region: PRK11099 1072459006314 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 1072459006315 CPxP motif; other site 1072459006316 hypothetical protein; Provisional; Region: PRK09951 1072459006317 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1072459006318 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1072459006319 Coenzyme A binding pocket [chemical binding]; other site 1072459006320 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 1072459006321 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 1072459006322 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 1072459006323 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1072459006324 flagellar motor switch protein FliG; Region: fliG; TIGR00207 1072459006325 FliG C-terminal domain; Region: FliG_C; pfam01706 1072459006326 flagellar assembly protein H; Validated; Region: fliH; PRK05687 1072459006327 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 1072459006328 Flagellar assembly protein FliH; Region: FliH; pfam02108 1072459006329 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 1072459006330 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1072459006331 Walker A motif/ATP binding site; other site 1072459006332 Walker B motif; other site 1072459006333 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 1072459006334 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 1072459006335 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 1072459006336 flagellar hook-length control protein; Provisional; Region: PRK10118 1072459006337 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 1072459006338 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1072459006339 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1072459006340 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 1072459006341 flagellar motor switch protein; Validated; Region: fliN; PRK05698 1072459006342 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 1072459006343 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1072459006344 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1072459006345 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1072459006346 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 1072459006347 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1072459006348 DNA binding residues [nucleotide binding] 1072459006349 dimerization interface [polypeptide binding]; other site 1072459006350 hypothetical protein; Provisional; Region: PRK10708 1072459006351 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 1072459006352 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 1072459006353 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1072459006354 active site 1072459006355 motif I; other site 1072459006356 motif II; other site 1072459006357 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 1072459006358 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1072459006359 metal binding site [ion binding]; metal-binding site 1072459006360 active site 1072459006361 I-site; other site 1072459006362 Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293 1072459006363 hypothetical protein; Provisional; Region: PRK10062 1072459006364 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 1072459006365 EamA-like transporter family; Region: EamA; pfam00892 1072459006366 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 1072459006367 additional DNA contacts [nucleotide binding]; other site 1072459006368 mismatch recognition site; other site 1072459006369 active site 1072459006370 zinc binding site [ion binding]; other site 1072459006371 DNA intercalation site [nucleotide binding]; other site 1072459006372 DNA cytosine methylase; Provisional; Region: PRK10458 1072459006373 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1072459006374 cofactor binding site; other site 1072459006375 DNA binding site [nucleotide binding] 1072459006376 substrate interaction site [chemical binding]; other site 1072459006377 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1072459006378 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1072459006379 Zn2+ binding site [ion binding]; other site 1072459006380 Mg2+ binding site [ion binding]; other site 1072459006381 chaperone protein HchA; Provisional; Region: PRK04155 1072459006382 Type 1 glutamine amidotransferase (GATase1)-like domain found in Escherichia coli Hsp31 protein (EcHsp31); Region: GATase1_EcHsp31_like; cd03148 1072459006383 dimer interface [polypeptide binding]; other site 1072459006384 metal binding site [ion binding]; metal-binding site 1072459006385 potential oxyanion hole; other site 1072459006386 potential catalytic triad [active] 1072459006387 conserved cys residue [active] 1072459006388 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1072459006389 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1072459006390 dimer interface [polypeptide binding]; other site 1072459006391 phosphorylation site [posttranslational modification] 1072459006392 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1072459006393 ATP binding site [chemical binding]; other site 1072459006394 Mg2+ binding site [ion binding]; other site 1072459006395 G-X-G motif; other site 1072459006396 transcriptional regulatory protein YedW; Provisional; Region: PRK11517 1072459006397 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1072459006398 active site 1072459006399 phosphorylation site [posttranslational modification] 1072459006400 intermolecular recognition site; other site 1072459006401 dimerization interface [polypeptide binding]; other site 1072459006402 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1072459006403 DNA binding site [nucleotide binding] 1072459006404 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1072459006405 active site 1072459006406 homotetramer interface [polypeptide binding]; other site 1072459006407 TMAO/DMSO reductase; Reviewed; Region: PRK05363 1072459006408 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 1072459006409 Moco binding site; other site 1072459006410 metal coordination site [ion binding]; other site 1072459006411 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 1072459006412 zinc/cadmium-binding protein; Provisional; Region: PRK10306 1072459006413 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 1072459006414 integrase; Provisional; Region: PRK09692 1072459006415 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1072459006416 active site 1072459006417 Int/Topo IB signature motif; other site 1072459006418 salicylate synthase Irp9; Reviewed; Region: PRK06772 1072459006419 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1072459006420 muropeptide transporter; Validated; Region: ampG; cl17669 1072459006421 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1072459006422 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1072459006423 Walker A/P-loop; other site 1072459006424 ATP binding site [chemical binding]; other site 1072459006425 Q-loop/lid; other site 1072459006426 ABC transporter signature motif; other site 1072459006427 Walker B; other site 1072459006428 D-loop; other site 1072459006429 H-loop/switch region; other site 1072459006430 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1072459006431 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1072459006432 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1072459006433 Walker A/P-loop; other site 1072459006434 ATP binding site [chemical binding]; other site 1072459006435 Q-loop/lid; other site 1072459006436 ABC transporter signature motif; other site 1072459006437 Walker B; other site 1072459006438 D-loop; other site 1072459006439 H-loop/switch region; other site 1072459006440 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1072459006441 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1072459006442 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1072459006443 Condensation domain; Region: Condensation; pfam00668 1072459006444 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1072459006445 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1072459006446 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 1072459006447 acyl-activating enzyme (AAE) consensus motif; other site 1072459006448 AMP binding site [chemical binding]; other site 1072459006449 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1072459006450 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1072459006451 S-adenosylmethionine binding site [chemical binding]; other site 1072459006452 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1072459006453 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1072459006454 Condensation domain; Region: Condensation; pfam00668 1072459006455 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1072459006456 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1072459006457 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1072459006458 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1072459006459 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1072459006460 active site 1072459006461 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1072459006462 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1072459006463 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1072459006464 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 1072459006465 KR domain; Region: KR; pfam08659 1072459006466 NADP binding site [chemical binding]; other site 1072459006467 active site 1072459006468 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1072459006469 Condensation domain; Region: Condensation; pfam00668 1072459006470 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1072459006471 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1072459006472 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1072459006473 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1072459006474 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1072459006475 Oxidoreductase (NAD-binding), involved in siderophore biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PchG; COG4693 1072459006476 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1072459006477 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1072459006478 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 1072459006479 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1072459006480 acyl-activating enzyme (AAE) consensus motif; other site 1072459006481 active site 1072459006482 AMP binding site [chemical binding]; other site 1072459006483 substrate binding site [chemical binding]; other site 1072459006484 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1072459006485 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1072459006486 N-terminal plug; other site 1072459006487 ligand-binding site [chemical binding]; other site 1072459006488 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 1072459006489 potential frameshift: common BLAST hit: gi|254161980|ref|YP_003045088.1| adhesin 1072459006490 potential frameshift: common BLAST hit: gi|117624169|ref|YP_853082.1| autotransporter 1072459006491 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 1072459006492 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 1072459006493 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 1072459006494 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 1072459006495 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1072459006496 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1072459006497 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1072459006498 shikimate transporter; Provisional; Region: PRK09952 1072459006499 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459006500 putative substrate translocation pore; other site 1072459006501 AMP nucleosidase; Provisional; Region: PRK08292 1072459006502 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 1072459006503 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1072459006504 hypothetical protein; Provisional; Region: PRK12378 1072459006505 MATE family multidrug exporter; Provisional; Region: PRK10189 1072459006506 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 1072459006507 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 1072459006508 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1072459006509 The C-terminal substrate binding domain of LysR-type transcriptional regulator Cbl, which is required for expression of sulfate starvation-inducible (ssi) genes, contains the type 2 periplasmic binding fold; Region: PBP2_Cbl; cd08444 1072459006510 putative substrate binding site [chemical binding]; other site 1072459006511 dimerization interface [polypeptide binding]; other site 1072459006512 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 1072459006513 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1072459006514 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 1072459006515 putative dimerization interface [polypeptide binding]; other site 1072459006516 L,D-transpeptidase; Provisional; Region: PRK10190 1072459006517 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1072459006518 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1072459006519 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1072459006520 putative dimer interface [polypeptide binding]; other site 1072459006521 active site pocket [active] 1072459006522 putative cataytic base [active] 1072459006523 cobalamin 5'-phosphate synthase/cobalamin synthase; Region: cobS; TIGR00317 1072459006524 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1072459006525 homotrimer interface [polypeptide binding]; other site 1072459006526 Walker A motif; other site 1072459006527 GTP binding site [chemical binding]; other site 1072459006528 Walker B motif; other site 1072459006529 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1072459006530 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1072459006531 N-terminal plug; other site 1072459006532 ligand-binding site [chemical binding]; other site 1072459006533 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1072459006534 ParB-like nuclease domain; Region: ParBc; cl02129 1072459006535 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 1072459006536 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1072459006537 Active Sites [active] 1072459006538 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 1072459006539 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 1072459006540 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1072459006541 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1072459006542 DXD motif; other site 1072459006543 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1072459006544 putative trimer interface [polypeptide binding]; other site 1072459006545 putative CoA binding site [chemical binding]; other site 1072459006546 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1072459006547 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1072459006548 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1072459006549 substrate binding site [chemical binding]; other site 1072459006550 dimer interface [polypeptide binding]; other site 1072459006551 ATP binding site [chemical binding]; other site 1072459006552 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1072459006553 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 1072459006554 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1072459006555 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1072459006556 Transposase; Region: HTH_Tnp_1; pfam01527 1072459006557 putative transposase OrfB; Reviewed; Region: PHA02517 1072459006558 Integrase core domain; Region: rve; pfam00665 1072459006559 Integrase core domain; Region: rve_3; pfam13683 1072459006560 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1072459006561 Transposase; Region: HTH_Tnp_1; cl17663 1072459006562 HTH-like domain; Region: HTH_21; pfam13276 1072459006563 Integrase core domain; Region: rve; pfam00665 1072459006564 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1072459006565 Integrase core domain; Region: rve_3; pfam13683 1072459006566 Predicted GTPase [General function prediction only]; Region: COG3596 1072459006567 YfjP GTPase; Region: YfjP; cd11383 1072459006568 G1 box; other site 1072459006569 GTP/Mg2+ binding site [chemical binding]; other site 1072459006570 Switch I region; other site 1072459006571 G2 box; other site 1072459006572 Switch II region; other site 1072459006573 G3 box; other site 1072459006574 G4 box; other site 1072459006575 G5 box; other site 1072459006576 hypothetical protein; Provisional; Region: PRK09866 1072459006577 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1072459006578 G1 box; other site 1072459006579 GTP/Mg2+ binding site [chemical binding]; other site 1072459006580 G2 box; other site 1072459006581 Switch I region; other site 1072459006582 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1072459006583 G3 box; other site 1072459006584 Switch II region; other site 1072459006585 G4 box; other site 1072459006586 YjcZ-like protein; Region: YjcZ; pfam13990 1072459006587 YjcZ-like protein; Region: YjcZ; pfam13990 1072459006588 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1072459006589 nucleophile elbow; other site 1072459006590 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 1072459006591 Domain of unknown function (DUF932); Region: DUF932; pfam06067 1072459006592 Antirestriction protein; Region: Antirestrict; pfam03230 1072459006593 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 1072459006594 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1072459006595 MPN+ (JAMM) motif; other site 1072459006596 Zinc-binding site [ion binding]; other site 1072459006597 Protein of unknown function (DUF987); Region: DUF987; pfam06174 1072459006598 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 1072459006599 hypothetical protein; Provisional; Region: PRK05423 1072459006600 Predicted membrane protein [Function unknown]; Region: COG1289 1072459006601 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1072459006602 DNA gyrase inhibitor; Provisional; Region: PRK10016 1072459006603 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 1072459006604 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1072459006605 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1072459006606 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 1072459006607 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1072459006608 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1072459006609 exonuclease I; Provisional; Region: sbcB; PRK11779 1072459006610 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 1072459006611 active site 1072459006612 catalytic site [active] 1072459006613 substrate binding site [chemical binding]; other site 1072459006614 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 1072459006615 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1072459006616 CPxP motif; other site 1072459006617 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 1072459006618 Sulphur transport; Region: Sulf_transp; pfam04143 1072459006619 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1072459006620 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1072459006621 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1072459006622 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1072459006623 dimerization interface [polypeptide binding]; other site 1072459006624 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1072459006625 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 1072459006626 putative NAD(P) binding site [chemical binding]; other site 1072459006627 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1072459006628 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1072459006629 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1072459006630 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 1072459006631 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1072459006632 NAD binding site [chemical binding]; other site 1072459006633 dimerization interface [polypeptide binding]; other site 1072459006634 product binding site; other site 1072459006635 substrate binding site [chemical binding]; other site 1072459006636 zinc binding site [ion binding]; other site 1072459006637 catalytic residues [active] 1072459006638 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 1072459006639 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1072459006640 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1072459006641 homodimer interface [polypeptide binding]; other site 1072459006642 catalytic residue [active] 1072459006643 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 1072459006644 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1072459006645 active site 1072459006646 motif I; other site 1072459006647 motif II; other site 1072459006648 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1072459006649 putative active site pocket [active] 1072459006650 4-fold oligomerization interface [polypeptide binding]; other site 1072459006651 metal binding residues [ion binding]; metal-binding site 1072459006652 3-fold/trimer interface [polypeptide binding]; other site 1072459006653 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 1072459006654 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1072459006655 putative active site [active] 1072459006656 oxyanion strand; other site 1072459006657 catalytic triad [active] 1072459006658 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1072459006659 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1072459006660 catalytic residues [active] 1072459006661 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1072459006662 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1072459006663 substrate binding site [chemical binding]; other site 1072459006664 glutamase interaction surface [polypeptide binding]; other site 1072459006665 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 1072459006666 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1072459006667 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1072459006668 metal binding site [ion binding]; metal-binding site 1072459006669 chain length determinant protein WzzB; Provisional; Region: PRK15471 1072459006670 Chain length determinant protein; Region: Wzz; pfam02706 1072459006671 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 1072459006672 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1072459006673 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1072459006674 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1072459006675 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1072459006676 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1072459006677 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1072459006678 phosphomannomutase CpsG; Provisional; Region: PRK15414 1072459006679 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1072459006680 active site 1072459006681 substrate binding site [chemical binding]; other site 1072459006682 metal binding site [ion binding]; metal-binding site 1072459006683 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 1072459006684 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1072459006685 Substrate binding site; other site 1072459006686 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 1072459006687 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1072459006688 GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis; Region: GT2_AmsE_like; cd04195 1072459006689 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1072459006690 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1072459006691 ornithine decarboxylase SpeF; Region: ODC_inducible; TIGR04301 1072459006692 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1072459006693 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1072459006694 inhibitor-cofactor binding pocket; inhibition site 1072459006695 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1072459006696 catalytic residue [active] 1072459006697 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1072459006698 colanic acid exporter; Provisional; Region: PRK10459 1072459006699 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 1072459006700 glucose-1-phosphate thymidylyltransferase RfbA; Provisional; Region: PRK15480 1072459006701 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1072459006702 substrate binding site; other site 1072459006703 tetramer interface; other site 1072459006704 dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987 1072459006705 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1072459006706 NADP binding site [chemical binding]; other site 1072459006707 active site 1072459006708 putative substrate binding site [chemical binding]; other site 1072459006709 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 1072459006710 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1072459006711 NAD binding site [chemical binding]; other site 1072459006712 substrate binding site [chemical binding]; other site 1072459006713 homodimer interface [polypeptide binding]; other site 1072459006714 active site 1072459006715 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1072459006716 active site 1072459006717 tetramer interface; other site 1072459006718 putative colanic acid biosynthesis protein; Provisional; Region: wcaM; PRK10123 1072459006719 colanic acid biosynthesis glycosyltransferase WcaL; Region: wcaL; TIGR04005 1072459006720 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 1072459006721 putative ADP-binding pocket [chemical binding]; other site 1072459006722 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 1072459006723 colanic acid biosynthesis pyruvyl transferase WcaK; Region: wcaK; TIGR04006 1072459006724 colanic acid exporter; Provisional; Region: PRK10459 1072459006725 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1072459006726 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 1072459006727 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 1072459006728 phosphomannomutase CpsG; Provisional; Region: PRK15414 1072459006729 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1072459006730 active site 1072459006731 substrate binding site [chemical binding]; other site 1072459006732 metal binding site [ion binding]; metal-binding site 1072459006733 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 1072459006734 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1072459006735 Substrate binding site; other site 1072459006736 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 1072459006737 colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007 1072459006738 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1072459006739 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 1072459006740 active site 1072459006741 GDP-Mannose binding site [chemical binding]; other site 1072459006742 dimer interface [polypeptide binding]; other site 1072459006743 modified nudix motif 1072459006744 metal binding site [ion binding]; metal-binding site 1072459006745 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 1072459006746 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 1072459006747 NADP binding site [chemical binding]; other site 1072459006748 active site 1072459006749 putative substrate binding site [chemical binding]; other site 1072459006750 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1072459006751 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1072459006752 NADP-binding site; other site 1072459006753 homotetramer interface [polypeptide binding]; other site 1072459006754 substrate binding site [chemical binding]; other site 1072459006755 homodimer interface [polypeptide binding]; other site 1072459006756 active site 1072459006757 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 1072459006758 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 1072459006759 putative trimer interface [polypeptide binding]; other site 1072459006760 putative active site [active] 1072459006761 putative substrate binding site [chemical binding]; other site 1072459006762 putative CoA binding site [chemical binding]; other site 1072459006763 putative glycosyl transferase; Provisional; Region: PRK10063 1072459006764 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 1072459006765 metal-binding site 1072459006766 putative colanic acid polymerase WcaD; Region: WcaD; TIGR04010 1072459006767 colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015 1072459006768 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1072459006769 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1072459006770 putative acyl transferase; Provisional; Region: PRK10191 1072459006771 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1072459006772 trimer interface [polypeptide binding]; other site 1072459006773 active site 1072459006774 substrate binding site [chemical binding]; other site 1072459006775 CoA binding site [chemical binding]; other site 1072459006776 putative glycosyl transferase; Provisional; Region: PRK10018 1072459006777 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1072459006778 active site 1072459006779 tyrosine kinase; Provisional; Region: PRK11519 1072459006780 Chain length determinant protein; Region: Wzz; pfam02706 1072459006781 Chain length determinant protein; Region: Wzz; cl15801 1072459006782 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1072459006783 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1072459006784 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1072459006785 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1072459006786 active site 1072459006787 polysaccharide export protein Wza; Provisional; Region: PRK15078 1072459006788 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1072459006789 SLBB domain; Region: SLBB; pfam10531 1072459006790 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1072459006791 FOG: CBS domain [General function prediction only]; Region: COG0517 1072459006792 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1072459006793 Transporter associated domain; Region: CorC_HlyC; smart01091 1072459006794 Phage-related protein [Function unknown]; Region: COG4679 1072459006795 Uncharacterized conserved small protein [Function unknown]; Region: COG5606 1072459006796 putative assembly protein; Provisional; Region: PRK10833 1072459006797 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1072459006798 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1072459006799 trimer interface [polypeptide binding]; other site 1072459006800 active site 1072459006801 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1072459006802 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1072459006803 ATP-binding site [chemical binding]; other site 1072459006804 Sugar specificity; other site 1072459006805 Pyrimidine base specificity; other site 1072459006806 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 1072459006807 putative diguanylate cyclase; Provisional; Region: PRK09776 1072459006808 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1072459006809 putative active site [active] 1072459006810 heme pocket [chemical binding]; other site 1072459006811 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1072459006812 putative active site [active] 1072459006813 heme pocket [chemical binding]; other site 1072459006814 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1072459006815 putative active site [active] 1072459006816 heme pocket [chemical binding]; other site 1072459006817 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1072459006818 metal binding site [ion binding]; metal-binding site 1072459006819 active site 1072459006820 I-site; other site 1072459006821 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 1072459006822 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 1072459006823 AlkA N-terminal domain; Region: AlkA_N; smart01009 1072459006824 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1072459006825 minor groove reading motif; other site 1072459006826 helix-hairpin-helix signature motif; other site 1072459006827 substrate binding pocket [chemical binding]; other site 1072459006828 active site 1072459006829 putative chaperone; Provisional; Region: PRK11678 1072459006830 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 1072459006831 nucleotide binding site [chemical binding]; other site 1072459006832 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1072459006833 SBD interface [polypeptide binding]; other site 1072459006834 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248 1072459006835 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1072459006836 substrate binding site [chemical binding]; other site 1072459006837 activation loop (A-loop); other site 1072459006838 Protein phosphatase 2C; Region: PP2C_2; pfam13672 1072459006839 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 1072459006840 metal ion-dependent adhesion site (MIDAS); other site 1072459006841 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 1072459006842 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1072459006843 HlyD family secretion protein; Region: HlyD_3; pfam13437 1072459006844 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 1072459006845 Protein export membrane protein; Region: SecD_SecF; cl14618 1072459006846 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 1072459006847 putative transporter; Provisional; Region: PRK10504 1072459006848 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459006849 putative substrate translocation pore; other site 1072459006850 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459006851 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 1072459006852 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1072459006853 dimerization interface [polypeptide binding]; other site 1072459006854 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1072459006855 dimer interface [polypeptide binding]; other site 1072459006856 phosphorylation site [posttranslational modification] 1072459006857 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1072459006858 ATP binding site [chemical binding]; other site 1072459006859 Mg2+ binding site [ion binding]; other site 1072459006860 G-X-G motif; other site 1072459006861 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 1072459006862 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1072459006863 active site 1072459006864 phosphorylation site [posttranslational modification] 1072459006865 intermolecular recognition site; other site 1072459006866 dimerization interface [polypeptide binding]; other site 1072459006867 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1072459006868 DNA binding site [nucleotide binding] 1072459006869 Uncharacterized conserved protein [Function unknown]; Region: COG3422 1072459006870 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 1072459006871 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 1072459006872 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 1072459006873 putative protease; Provisional; Region: PRK15452 1072459006874 Peptidase family U32; Region: Peptidase_U32; pfam01136 1072459006875 lipid kinase; Reviewed; Region: PRK13054 1072459006876 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1072459006877 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1072459006878 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1072459006879 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1072459006880 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 1072459006881 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 1072459006882 putative NAD(P) binding site [chemical binding]; other site 1072459006883 catalytic Zn binding site [ion binding]; other site 1072459006884 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 1072459006885 PTS system, galactitol-specific IIC component; Region: EIIC-GAT; TIGR00827 1072459006886 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1072459006887 active site 1072459006888 P-loop; other site 1072459006889 phosphorylation site [posttranslational modification] 1072459006890 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1072459006891 active site 1072459006892 phosphorylation site [posttranslational modification] 1072459006893 D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052 1072459006894 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1072459006895 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1072459006896 intersubunit interface [polypeptide binding]; other site 1072459006897 active site 1072459006898 zinc binding site [ion binding]; other site 1072459006899 Na+ binding site [ion binding]; other site 1072459006900 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 1072459006901 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1072459006902 putative active site; other site 1072459006903 catalytic residue [active] 1072459006904 nucleoside transporter; Region: 2A0110; TIGR00889 1072459006905 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459006906 putative substrate translocation pore; other site 1072459006907 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 1072459006908 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1072459006909 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1072459006910 substrate binding site [chemical binding]; other site 1072459006911 ATP binding site [chemical binding]; other site 1072459006912 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1072459006913 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1072459006914 DNA-binding site [nucleotide binding]; DNA binding site 1072459006915 UTRA domain; Region: UTRA; pfam07702 1072459006916 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 1072459006917 YegX is an uncharacterized bacterial protein with a glycosyl hydrolase family 25 (GH25) catalytic domain that is similar in sequence to the CH-type (Chalaropsis-type) lysozymes of the GH25 family of endolysins; Region: GH25_YegX-like; cd06524 1072459006918 active site 1072459006919 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1072459006920 dimer interface [polypeptide binding]; other site 1072459006921 substrate binding site [chemical binding]; other site 1072459006922 ATP binding site [chemical binding]; other site 1072459006923 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1072459006924 substrate binding site [chemical binding]; other site 1072459006925 multimerization interface [polypeptide binding]; other site 1072459006926 ATP binding site [chemical binding]; other site 1072459006927 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 1072459006928 putative metal binding site [ion binding]; other site 1072459006929 putative homodimer interface [polypeptide binding]; other site 1072459006930 putative homotetramer interface [polypeptide binding]; other site 1072459006931 putative homodimer-homodimer interface [polypeptide binding]; other site 1072459006932 putative allosteric switch controlling residues; other site 1072459006933 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 1072459006934 Predicted integral membrane protein [Function unknown]; Region: COG5455 1072459006935 putative fimbrial-like adhesin protein StcD; Provisional; Region: PRK15252 1072459006936 putative fimbrial biosynthesis regulatory protein; Provisional; Region: PRK15216 1072459006937 fimbrial outer membrane usher protein; Provisional; Region: PRK15217 1072459006938 PapC N-terminal domain; Region: PapC_N; pfam13954 1072459006939 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1072459006940 PapC C-terminal domain; Region: PapC_C; pfam13953 1072459006941 putative fimbrial assembly chaperone protein StcB; Provisional; Region: PRK15253 1072459006942 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1072459006943 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1072459006944 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1072459006945 antiporter inner membrane protein; Provisional; Region: PRK11670 1072459006946 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1072459006947 Walker A motif; other site 1072459006948 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 1072459006949 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1072459006950 active site 1072459006951 HIGH motif; other site 1072459006952 KMSKS motif; other site 1072459006953 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1072459006954 tRNA binding surface [nucleotide binding]; other site 1072459006955 anticodon binding site; other site 1072459006956 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1072459006957 dimer interface [polypeptide binding]; other site 1072459006958 putative tRNA-binding site [nucleotide binding]; other site 1072459006959 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 1072459006960 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 1072459006961 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 1072459006962 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 1072459006963 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 1072459006964 MoxR-like ATPases [General function prediction only]; Region: COG0714 1072459006965 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1072459006966 Walker A motif; other site 1072459006967 ATP binding site [chemical binding]; other site 1072459006968 Walker B motif; other site 1072459006969 arginine finger; other site 1072459006970 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 1072459006971 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 1072459006972 metal ion-dependent adhesion site (MIDAS); other site 1072459006973 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 1072459006974 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 1072459006975 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1072459006976 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1072459006977 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 1072459006978 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1072459006979 active site 1072459006980 phosphorylation site [posttranslational modification] 1072459006981 intermolecular recognition site; other site 1072459006982 dimerization interface [polypeptide binding]; other site 1072459006983 LytTr DNA-binding domain; Region: LytTR; pfam04397 1072459006984 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1072459006985 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1072459006986 GAF domain; Region: GAF; pfam01590 1072459006987 Histidine kinase; Region: His_kinase; pfam06580 1072459006988 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1072459006989 ATP binding site [chemical binding]; other site 1072459006990 Mg2+ binding site [ion binding]; other site 1072459006991 G-X-G motif; other site 1072459006992 Protein of unknown function (DUF4035); Region: DUF4035; pfam13227 1072459006993 Phage tail assembly chaperone; Region: Phage_TAC; pfam06222 1072459006994 Immunoglobulin I-set domain; Region: I-set; pfam07679 1072459006995 Immunoglobulin domain; Region: Ig_2; pfam13895 1072459006996 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 1072459006997 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 1072459006998 Bacteriophage head-tail adaptor [General function prediction only]; Region: COG5614 1072459006999 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 1072459007000 Phage-related protein [Function unknown]; Region: COG4695 1072459007001 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 1072459007002 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 1072459007003 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1072459007004 Phage capsid family; Region: Phage_capsid; pfam05065 1072459007005 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 1072459007006 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1072459007007 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1072459007008 active site 1072459007009 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 1072459007010 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1072459007011 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 1072459007012 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1072459007013 catalytic residues [active] 1072459007014 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 1072459007015 Lysis protein S; Region: Lysis_S; pfam04971 1072459007016 Protein of unknown function (DUF826); Region: DUF826; pfam05696 1072459007017 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 1072459007018 Domain of unknown function (DUF303); Region: DUF303; pfam03629 1072459007019 TolA C-terminal; Region: TolA; pfam06519 1072459007020 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 1072459007021 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1072459007022 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1072459007023 trimer interface [polypeptide binding]; other site 1072459007024 eyelet of channel; other site 1072459007025 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 1072459007026 Protein of unknown function (DUF968); Region: DUF968; pfam06147 1072459007027 replicative DNA helicase; Region: DnaB; TIGR00665 1072459007028 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1072459007029 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1072459007030 Walker A motif; other site 1072459007031 ATP binding site [chemical binding]; other site 1072459007032 Walker B motif; other site 1072459007033 DNA binding loops [nucleotide binding] 1072459007034 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1072459007035 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1072459007036 Walker A motif; other site 1072459007037 ATP binding site [chemical binding]; other site 1072459007038 Walker B motif; other site 1072459007039 arginine finger; other site 1072459007040 Ash protein family; Region: Phage_ASH; pfam10554 1072459007041 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 1072459007042 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 1072459007043 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1072459007044 non-specific DNA binding site [nucleotide binding]; other site 1072459007045 Predicted transcriptional regulator [Transcription]; Region: COG2932 1072459007046 salt bridge; other site 1072459007047 sequence-specific DNA binding site [nucleotide binding]; other site 1072459007048 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1072459007049 Catalytic site [active] 1072459007050 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1072459007051 non-specific DNA binding site [nucleotide binding]; other site 1072459007052 salt bridge; other site 1072459007053 sequence-specific DNA binding site [nucleotide binding]; other site 1072459007054 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 1072459007055 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 1072459007056 Protein of unknown function (DUF551); Region: DUF551; pfam04448 1072459007057 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 1072459007058 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 1072459007059 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 1072459007060 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1072459007061 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 1072459007062 Int/Topo IB signature motif; other site 1072459007063 transcriptional regulator MirA; Provisional; Region: PRK15043 1072459007064 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1072459007065 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1072459007066 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1072459007067 dimer interface [polypeptide binding]; other site 1072459007068 conserved gate region; other site 1072459007069 putative PBP binding loops; other site 1072459007070 ABC-ATPase subunit interface; other site 1072459007071 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1072459007072 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1072459007073 Walker A/P-loop; other site 1072459007074 ATP binding site [chemical binding]; other site 1072459007075 Q-loop/lid; other site 1072459007076 ABC transporter signature motif; other site 1072459007077 Walker B; other site 1072459007078 D-loop; other site 1072459007079 H-loop/switch region; other site 1072459007080 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1072459007081 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1072459007082 dimer interface [polypeptide binding]; other site 1072459007083 conserved gate region; other site 1072459007084 ABC-ATPase subunit interface; other site 1072459007085 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1072459007086 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 1072459007087 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1072459007088 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1072459007089 D-lactate dehydrogenase; Provisional; Region: PRK11183 1072459007090 FAD binding domain; Region: FAD_binding_4; pfam01565 1072459007091 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 1072459007092 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 1072459007093 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1072459007094 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 1072459007095 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1072459007096 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1072459007097 oxidoreductase; Provisional; Region: PRK12743 1072459007098 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1072459007099 NAD(P) binding site [chemical binding]; other site 1072459007100 active site 1072459007101 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1072459007102 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1072459007103 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1072459007104 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 1072459007105 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1072459007106 FMN binding site [chemical binding]; other site 1072459007107 active site 1072459007108 catalytic residues [active] 1072459007109 substrate binding site [chemical binding]; other site 1072459007110 hypothetical protein; Provisional; Region: PRK01821 1072459007111 hypothetical protein; Provisional; Region: PRK10711 1072459007112 cytidine deaminase; Provisional; Region: PRK09027 1072459007113 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1072459007114 active site 1072459007115 catalytic motif [active] 1072459007116 Zn binding site [ion binding]; other site 1072459007117 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1072459007118 active site 1072459007119 catalytic motif [active] 1072459007120 Zn binding site [ion binding]; other site 1072459007121 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1072459007122 putative active site [active] 1072459007123 Protein of unknown function (DUF2542); Region: DUF2542; pfam10808 1072459007124 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 1072459007125 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1072459007126 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1072459007127 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 1072459007128 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 1072459007129 homodimer interface [polypeptide binding]; other site 1072459007130 active site 1072459007131 FMN binding site [chemical binding]; other site 1072459007132 substrate binding site [chemical binding]; other site 1072459007133 4Fe-4S binding domain; Region: Fer4; pfam00037 1072459007134 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1072459007135 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1072459007136 TM-ABC transporter signature motif; other site 1072459007137 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1072459007138 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 1072459007139 Walker A/P-loop; other site 1072459007140 ATP binding site [chemical binding]; other site 1072459007141 Q-loop/lid; other site 1072459007142 ABC transporter signature motif; other site 1072459007143 Walker B; other site 1072459007144 D-loop; other site 1072459007145 H-loop/switch region; other site 1072459007146 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1072459007147 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 1072459007148 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 1072459007149 ligand binding site [chemical binding]; other site 1072459007150 calcium binding site [ion binding]; other site 1072459007151 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 1072459007152 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1072459007153 DNA binding site [nucleotide binding] 1072459007154 domain linker motif; other site 1072459007155 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1072459007156 dimerization interface (closed form) [polypeptide binding]; other site 1072459007157 ligand binding site [chemical binding]; other site 1072459007158 Predicted membrane protein [Function unknown]; Region: COG2311 1072459007159 hypothetical protein; Provisional; Region: PRK10835 1072459007160 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1072459007161 homodecamer interface [polypeptide binding]; other site 1072459007162 GTP cyclohydrolase I; Provisional; Region: PLN03044 1072459007163 active site 1072459007164 putative catalytic site residues [active] 1072459007165 zinc binding site [ion binding]; other site 1072459007166 GTP-CH-I/GFRP interaction surface; other site 1072459007167 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 1072459007168 S-formylglutathione hydrolase; Region: PLN02442 1072459007169 lysine transporter; Provisional; Region: PRK10836 1072459007170 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 1072459007171 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1072459007172 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1072459007173 putative dimerization interface [polypeptide binding]; other site 1072459007174 conserved hypothetical integral membrane protein; Region: TIGR00698 1072459007175 endonuclease IV; Provisional; Region: PRK01060 1072459007176 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1072459007177 AP (apurinic/apyrimidinic) site pocket; other site 1072459007178 DNA interaction; other site 1072459007179 Metal-binding active site; metal-binding site 1072459007180 putative kinase; Provisional; Region: PRK09954 1072459007181 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1072459007182 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 1072459007183 substrate binding site [chemical binding]; other site 1072459007184 ATP binding site [chemical binding]; other site 1072459007185 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1072459007186 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1072459007187 Nucleoside recognition; Region: Gate; pfam07670 1072459007188 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1072459007189 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1072459007190 active site 1072459007191 tetramer interface [polypeptide binding]; other site 1072459007192 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 1072459007193 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1072459007194 ligand binding site [chemical binding]; other site 1072459007195 flexible hinge region; other site 1072459007196 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1072459007197 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1072459007198 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1072459007199 Nucleoside recognition; Region: Gate; pfam07670 1072459007200 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1072459007201 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 1072459007202 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 1072459007203 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1072459007204 substrate binding site [chemical binding]; other site 1072459007205 ATP binding site [chemical binding]; other site 1072459007206 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 1072459007207 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 1072459007208 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1072459007209 active site 1072459007210 P-loop; other site 1072459007211 phosphorylation site [posttranslational modification] 1072459007212 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 1072459007213 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1072459007214 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1072459007215 putative substrate binding site [chemical binding]; other site 1072459007216 putative ATP binding site [chemical binding]; other site 1072459007217 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 1072459007218 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1072459007219 active site 1072459007220 phosphorylation site [posttranslational modification] 1072459007221 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1072459007222 dimerization domain swap beta strand [polypeptide binding]; other site 1072459007223 regulatory protein interface [polypeptide binding]; other site 1072459007224 active site 1072459007225 regulatory phosphorylation site [posttranslational modification]; other site 1072459007226 sugar efflux transporter B; Provisional; Region: PRK15011 1072459007227 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459007228 putative substrate translocation pore; other site 1072459007229 Flagellin N-methylase; Region: FliB; pfam03692 1072459007230 elongation factor P; Provisional; Region: PRK04542 1072459007231 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1072459007232 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1072459007233 RNA binding site [nucleotide binding]; other site 1072459007234 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1072459007235 RNA binding site [nucleotide binding]; other site 1072459007236 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1072459007237 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1072459007238 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1072459007239 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1072459007240 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1072459007241 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1072459007242 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1072459007243 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1072459007244 active site 1072459007245 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 1072459007246 NlpC/P60 family; Region: NLPC_P60; pfam00877 1072459007247 phage resistance protein; Provisional; Region: PRK10551 1072459007248 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1072459007249 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1072459007250 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1072459007251 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1072459007252 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 1072459007253 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1072459007254 dimer interface [polypeptide binding]; other site 1072459007255 conserved gate region; other site 1072459007256 putative PBP binding loops; other site 1072459007257 ABC-ATPase subunit interface; other site 1072459007258 microcin C ABC transporter permease; Provisional; Region: PRK15021 1072459007259 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1072459007260 dimer interface [polypeptide binding]; other site 1072459007261 conserved gate region; other site 1072459007262 ABC-ATPase subunit interface; other site 1072459007263 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 1072459007264 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1072459007265 Walker A/P-loop; other site 1072459007266 ATP binding site [chemical binding]; other site 1072459007267 Q-loop/lid; other site 1072459007268 ABC transporter signature motif; other site 1072459007269 Walker B; other site 1072459007270 D-loop; other site 1072459007271 H-loop/switch region; other site 1072459007272 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1072459007273 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1072459007274 Walker A/P-loop; other site 1072459007275 ATP binding site [chemical binding]; other site 1072459007276 Q-loop/lid; other site 1072459007277 ABC transporter signature motif; other site 1072459007278 Walker B; other site 1072459007279 D-loop; other site 1072459007280 H-loop/switch region; other site 1072459007281 hypothetical protein; Provisional; Region: PRK11835 1072459007282 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459007283 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 1072459007284 putative substrate translocation pore; other site 1072459007285 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 1072459007286 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1072459007287 RNA binding surface [nucleotide binding]; other site 1072459007288 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1072459007289 active site 1072459007290 uracil binding [chemical binding]; other site 1072459007291 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1072459007292 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1072459007293 ATP binding site [chemical binding]; other site 1072459007294 putative Mg++ binding site [ion binding]; other site 1072459007295 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1072459007296 nucleotide binding region [chemical binding]; other site 1072459007297 ATP-binding site [chemical binding]; other site 1072459007298 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 1072459007299 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1072459007300 5S rRNA interface [nucleotide binding]; other site 1072459007301 CTC domain interface [polypeptide binding]; other site 1072459007302 L16 interface [polypeptide binding]; other site 1072459007303 Nucleoid-associated protein [General function prediction only]; Region: COG3081 1072459007304 nucleoid-associated protein NdpA; Validated; Region: PRK00378 1072459007305 hypothetical protein; Provisional; Region: PRK13689 1072459007306 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 1072459007307 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 1072459007308 Sulfatase; Region: Sulfatase; pfam00884 1072459007309 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 1072459007310 hypothetical protein; Provisional; Region: PRK09945 1072459007311 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 1072459007312 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1072459007313 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1072459007314 transcriptional regulator NarP; Provisional; Region: PRK10403 1072459007315 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1072459007316 active site 1072459007317 phosphorylation site [posttranslational modification] 1072459007318 intermolecular recognition site; other site 1072459007319 dimerization interface [polypeptide binding]; other site 1072459007320 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1072459007321 DNA binding residues [nucleotide binding] 1072459007322 dimerization interface [polypeptide binding]; other site 1072459007323 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 1072459007324 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 1072459007325 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1072459007326 binding surface 1072459007327 TPR motif; other site 1072459007328 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 1072459007329 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 1072459007330 catalytic residues [active] 1072459007331 central insert; other site 1072459007332 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 1072459007333 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 1072459007334 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 1072459007335 heme exporter protein CcmC; Region: ccmC; TIGR01191 1072459007336 heme exporter protein CcmB; Region: ccmB; TIGR01190 1072459007337 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 1072459007338 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 1072459007339 Walker A/P-loop; other site 1072459007340 ATP binding site [chemical binding]; other site 1072459007341 Q-loop/lid; other site 1072459007342 ABC transporter signature motif; other site 1072459007343 Walker B; other site 1072459007344 D-loop; other site 1072459007345 H-loop/switch region; other site 1072459007346 cytochrome c-type protein NapC; Provisional; Region: PRK10617 1072459007347 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 1072459007348 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 1072459007349 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 1072459007350 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1072459007351 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1072459007352 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 1072459007353 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 1072459007354 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1072459007355 [4Fe-4S] binding site [ion binding]; other site 1072459007356 molybdopterin cofactor binding site; other site 1072459007357 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1072459007358 molybdopterin cofactor binding site; other site 1072459007359 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 1072459007360 ferredoxin-type protein; Provisional; Region: PRK10194 1072459007361 tRNA synthetases class I (R); Region: tRNA-synt_1d; pfam00750 1072459007362 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 1072459007363 secondary substrate binding site; other site 1072459007364 primary substrate binding site; other site 1072459007365 inhibition loop; other site 1072459007366 dimerization interface [polypeptide binding]; other site 1072459007367 malate:quinone oxidoreductase; Validated; Region: PRK05257 1072459007368 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1072459007369 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 1072459007370 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1072459007371 Walker A/P-loop; other site 1072459007372 ATP binding site [chemical binding]; other site 1072459007373 Q-loop/lid; other site 1072459007374 ABC transporter signature motif; other site 1072459007375 Walker B; other site 1072459007376 D-loop; other site 1072459007377 H-loop/switch region; other site 1072459007378 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 1072459007379 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 1072459007380 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1072459007381 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1072459007382 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1072459007383 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1072459007384 DNA binding site [nucleotide binding] 1072459007385 active site 1072459007386 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 1072459007387 ApbE family; Region: ApbE; pfam02424 1072459007388 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1072459007389 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1072459007390 trimer interface [polypeptide binding]; other site 1072459007391 eyelet of channel; other site 1072459007392 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 1072459007393 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1072459007394 ATP binding site [chemical binding]; other site 1072459007395 G-X-G motif; other site 1072459007396 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1072459007397 putative binding surface; other site 1072459007398 active site 1072459007399 transcriptional regulator RcsB; Provisional; Region: PRK10840 1072459007400 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1072459007401 active site 1072459007402 phosphorylation site [posttranslational modification] 1072459007403 intermolecular recognition site; other site 1072459007404 dimerization interface [polypeptide binding]; other site 1072459007405 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1072459007406 DNA binding residues [nucleotide binding] 1072459007407 dimerization interface [polypeptide binding]; other site 1072459007408 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 1072459007409 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1072459007410 dimer interface [polypeptide binding]; other site 1072459007411 phosphorylation site [posttranslational modification] 1072459007412 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1072459007413 ATP binding site [chemical binding]; other site 1072459007414 Mg2+ binding site [ion binding]; other site 1072459007415 G-X-G motif; other site 1072459007416 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 1072459007417 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1072459007418 active site 1072459007419 phosphorylation site [posttranslational modification] 1072459007420 intermolecular recognition site; other site 1072459007421 dimerization interface [polypeptide binding]; other site 1072459007422 sensory histidine kinase AtoS; Provisional; Region: PRK11360 1072459007423 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1072459007424 putative active site [active] 1072459007425 heme pocket [chemical binding]; other site 1072459007426 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1072459007427 dimer interface [polypeptide binding]; other site 1072459007428 phosphorylation site [posttranslational modification] 1072459007429 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1072459007430 ATP binding site [chemical binding]; other site 1072459007431 Mg2+ binding site [ion binding]; other site 1072459007432 G-X-G motif; other site 1072459007433 acetoacetate metabolism regulatory protein AtoC; Provisional; Region: PRK11361 1072459007434 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1072459007435 active site 1072459007436 phosphorylation site [posttranslational modification] 1072459007437 intermolecular recognition site; other site 1072459007438 dimerization interface [polypeptide binding]; other site 1072459007439 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1072459007440 Walker A motif; other site 1072459007441 ATP binding site [chemical binding]; other site 1072459007442 Walker B motif; other site 1072459007443 arginine finger; other site 1072459007444 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1072459007445 acetyl-CoA:acetoacetyl-CoA transferase subunit alpha; Provisional; Region: PRK09920 1072459007446 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1072459007447 Short chain fatty acid transporter; Region: SCFA_trans; pfam02667 1072459007448 putative acyltransferase; Provisional; Region: PRK05790 1072459007449 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1072459007450 dimer interface [polypeptide binding]; other site 1072459007451 active site 1072459007452 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 1072459007453 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 1072459007454 Predicted secreted protein [Function unknown]; Region: COG5445 1072459007455 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 1072459007456 Predicted secreted protein [Function unknown]; Region: COG5445 1072459007457 Stage II sporulation protein; Region: SpoIID; pfam08486 1072459007458 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 1072459007459 MG2 domain; Region: A2M_N; pfam01835 1072459007460 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 1072459007461 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 1072459007462 Alpha-2-macroglobulin family; Region: A2M; pfam00207 1072459007463 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 1072459007464 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3234 1072459007465 DNA gyrase subunit A; Validated; Region: PRK05560 1072459007466 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1072459007467 CAP-like domain; other site 1072459007468 active site 1072459007469 primary dimer interface [polypeptide binding]; other site 1072459007470 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1072459007471 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1072459007472 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1072459007473 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1072459007474 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1072459007475 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1072459007476 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1072459007477 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1072459007478 active site pocket [active] 1072459007479 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1072459007480 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459007481 putative substrate translocation pore; other site 1072459007482 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1072459007483 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1072459007484 DNA-binding site [nucleotide binding]; DNA binding site 1072459007485 FCD domain; Region: FCD; pfam07729 1072459007486 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 1072459007487 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1072459007488 S-adenosylmethionine binding site [chemical binding]; other site 1072459007489 adhesin; Provisional; Region: PRK09752 1072459007490 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 1072459007491 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1072459007492 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 1072459007493 ATP cone domain; Region: ATP-cone; pfam03477 1072459007494 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1072459007495 active site 1072459007496 dimer interface [polypeptide binding]; other site 1072459007497 catalytic residues [active] 1072459007498 effector binding site; other site 1072459007499 R2 peptide binding site; other site 1072459007500 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1072459007501 dimer interface [polypeptide binding]; other site 1072459007502 putative radical transfer pathway; other site 1072459007503 diiron center [ion binding]; other site 1072459007504 tyrosyl radical; other site 1072459007505 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1072459007506 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1072459007507 catalytic loop [active] 1072459007508 iron binding site [ion binding]; other site 1072459007509 hypothetical protein; Provisional; Region: PRK09902 1072459007510 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1072459007511 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459007512 putative substrate translocation pore; other site 1072459007513 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1072459007514 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1072459007515 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1072459007516 dimerization interface [polypeptide binding]; other site 1072459007517 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 1072459007518 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 1072459007519 active site 1072459007520 catalytic site [active] 1072459007521 metal binding site [ion binding]; metal-binding site 1072459007522 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 1072459007523 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459007524 putative substrate translocation pore; other site 1072459007525 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 1072459007526 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1072459007527 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1072459007528 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 1072459007529 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 1072459007530 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 1072459007531 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1072459007532 Cysteine-rich domain; Region: CCG; pfam02754 1072459007533 Cysteine-rich domain; Region: CCG; pfam02754 1072459007534 hypothetical protein; Provisional; Region: PRK09956 1072459007535 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1072459007536 hypothetical protein; Provisional; Region: PRK09956 1072459007537 2-keto-3-deoxy-L-rhamnonate aldolase; Provisional; Region: PRK10128 1072459007538 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1072459007539 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459007540 putative substrate translocation pore; other site 1072459007541 putative transposase OrfB; Reviewed; Region: PHA02517 1072459007542 HTH-like domain; Region: HTH_21; pfam13276 1072459007543 Integrase core domain; Region: rve; pfam00665 1072459007544 Integrase core domain; Region: rve_3; pfam13683 1072459007545 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 1072459007546 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1072459007547 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1072459007548 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1072459007549 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1072459007550 Bacterial transcriptional regulator; Region: IclR; pfam01614 1072459007551 hypothetical protein; Provisional; Region: PRK03673 1072459007552 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1072459007553 putative MPT binding site; other site 1072459007554 Competence-damaged protein; Region: CinA; cl00666 1072459007555 YfaZ precursor; Region: YfaZ; pfam07437 1072459007556 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 1072459007557 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 1072459007558 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1072459007559 catalytic core [active] 1072459007560 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1072459007561 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1072459007562 inhibitor-cofactor binding pocket; inhibition site 1072459007563 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1072459007564 catalytic residue [active] 1072459007565 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1072459007566 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1072459007567 Ligand binding site; other site 1072459007568 Putative Catalytic site; other site 1072459007569 DXD motif; other site 1072459007570 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 1072459007571 ArnA, N-terminal formyltransferase domain; Region: FMT_core_ArnA_N; cd08644 1072459007572 substrate binding site [chemical binding]; other site 1072459007573 cosubstrate binding site; other site 1072459007574 catalytic site [active] 1072459007575 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 1072459007576 active site 1072459007577 hexamer interface [polypeptide binding]; other site 1072459007578 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 1072459007579 NAD binding site [chemical binding]; other site 1072459007580 substrate binding site [chemical binding]; other site 1072459007581 active site 1072459007582 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 1072459007583 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 1072459007584 putative active site [active] 1072459007585 putative catalytic site [active] 1072459007586 putative Zn binding site [ion binding]; other site 1072459007587 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 1072459007588 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1072459007589 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 1072459007590 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 1072459007591 signal transduction protein PmrD; Provisional; Region: PRK15450 1072459007592 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 1072459007593 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1072459007594 acyl-activating enzyme (AAE) consensus motif; other site 1072459007595 putative AMP binding site [chemical binding]; other site 1072459007596 putative active site [active] 1072459007597 putative CoA binding site [chemical binding]; other site 1072459007598 O-succinylbenzoate synthase; Provisional; Region: PRK05105 1072459007599 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1072459007600 active site 1072459007601 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1072459007602 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1072459007603 substrate binding site [chemical binding]; other site 1072459007604 oxyanion hole (OAH) forming residues; other site 1072459007605 trimer interface [polypeptide binding]; other site 1072459007606 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 1072459007607 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1072459007608 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1072459007609 dimer interface [polypeptide binding]; other site 1072459007610 tetramer interface [polypeptide binding]; other site 1072459007611 PYR/PP interface [polypeptide binding]; other site 1072459007612 TPP binding site [chemical binding]; other site 1072459007613 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1072459007614 TPP-binding site; other site 1072459007615 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 1072459007616 isochorismate synthases; Region: isochor_syn; TIGR00543 1072459007617 hypothetical protein; Provisional; Region: PRK10404 1072459007618 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1072459007619 Coenzyme A binding pocket [chemical binding]; other site 1072459007620 ribonuclease BN; Region: true_RNase_BN; TIGR02649 1072459007621 deubiquitinase; Provisional; Region: PRK11836 1072459007622 von Willebrand factor; Region: vWF_A; pfam12450 1072459007623 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1072459007624 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 1072459007625 metal ion-dependent adhesion site (MIDAS); other site 1072459007626 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 1072459007627 M28 Zn-Peptidases; Region: M28_like_1; cd05640 1072459007628 Peptidase family M28; Region: Peptidase_M28; pfam04389 1072459007629 metal binding site [ion binding]; metal-binding site 1072459007630 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 1072459007631 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1072459007632 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1072459007633 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1072459007634 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1072459007635 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1072459007636 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1072459007637 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1072459007638 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1072459007639 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1072459007640 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1072459007641 4Fe-4S binding domain; Region: Fer4; pfam00037 1072459007642 4Fe-4S binding domain; Region: Fer4; pfam00037 1072459007643 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1072459007644 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 1072459007645 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1072459007646 catalytic loop [active] 1072459007647 iron binding site [ion binding]; other site 1072459007648 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1072459007649 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 1072459007650 [4Fe-4S] binding site [ion binding]; other site 1072459007651 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 1072459007652 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 1072459007653 SLBB domain; Region: SLBB; pfam10531 1072459007654 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 1072459007655 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1072459007656 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1072459007657 putative dimer interface [polypeptide binding]; other site 1072459007658 [2Fe-2S] cluster binding site [ion binding]; other site 1072459007659 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 1072459007660 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1072459007661 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1072459007662 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 1072459007663 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 1072459007664 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 1072459007665 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1072459007666 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 1072459007667 putative dimerization interface [polypeptide binding]; other site 1072459007668 aminotransferase AlaT; Validated; Region: PRK09265 1072459007669 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1072459007670 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1072459007671 homodimer interface [polypeptide binding]; other site 1072459007672 catalytic residue [active] 1072459007673 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1072459007674 Zn2+ binding site [ion binding]; other site 1072459007675 Mg2+ binding site [ion binding]; other site 1072459007676 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1072459007677 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1072459007678 TrkA-C domain; Region: TrkA_C; pfam02080 1072459007679 TrkA-C domain; Region: TrkA_C; pfam02080 1072459007680 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1072459007681 putative phosphatase; Provisional; Region: PRK11587 1072459007682 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1072459007683 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1072459007684 motif II; other site 1072459007685 hypothetical protein; Validated; Region: PRK05445 1072459007686 hypothetical protein; Provisional; Region: PRK01816 1072459007687 propionate/acetate kinase; Provisional; Region: PRK12379 1072459007688 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1072459007689 phosphate acetyltransferase; Reviewed; Region: PRK05632 1072459007690 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1072459007691 DRTGG domain; Region: DRTGG; pfam07085 1072459007692 phosphate acetyltransferase; Region: pta; TIGR00651 1072459007693 hypothetical protein; Provisional; Region: PRK11588 1072459007694 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1072459007695 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 1072459007696 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 1072459007697 nudix motif; other site 1072459007698 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1072459007699 active site 1072459007700 metal binding site [ion binding]; metal-binding site 1072459007701 homotetramer interface [polypeptide binding]; other site 1072459007702 glutathione S-transferase; Provisional; Region: PRK15113 1072459007703 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1072459007704 C-terminal domain interface [polypeptide binding]; other site 1072459007705 GSH binding site (G-site) [chemical binding]; other site 1072459007706 dimer interface [polypeptide binding]; other site 1072459007707 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 1072459007708 N-terminal domain interface [polypeptide binding]; other site 1072459007709 putative dimer interface [polypeptide binding]; other site 1072459007710 putative substrate binding pocket (H-site) [chemical binding]; other site 1072459007711 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 1072459007712 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1072459007713 C-terminal domain interface [polypeptide binding]; other site 1072459007714 GSH binding site (G-site) [chemical binding]; other site 1072459007715 dimer interface [polypeptide binding]; other site 1072459007716 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 1072459007717 N-terminal domain interface [polypeptide binding]; other site 1072459007718 putative dimer interface [polypeptide binding]; other site 1072459007719 active site 1072459007720 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1072459007721 homooctamer interface [polypeptide binding]; other site 1072459007722 active site 1072459007723 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1072459007724 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1072459007725 putative NAD(P) binding site [chemical binding]; other site 1072459007726 putative active site [active] 1072459007727 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1072459007728 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 1072459007729 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1072459007730 homodimer interface [polypeptide binding]; other site 1072459007731 substrate-cofactor binding pocket; other site 1072459007732 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1072459007733 catalytic residue [active] 1072459007734 putative transposase; Provisional; Region: PRK09857 1072459007735 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1072459007736 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 1072459007737 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1072459007738 Walker A/P-loop; other site 1072459007739 ATP binding site [chemical binding]; other site 1072459007740 Q-loop/lid; other site 1072459007741 ABC transporter signature motif; other site 1072459007742 Walker B; other site 1072459007743 D-loop; other site 1072459007744 H-loop/switch region; other site 1072459007745 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1072459007746 dimer interface [polypeptide binding]; other site 1072459007747 conserved gate region; other site 1072459007748 putative PBP binding loops; other site 1072459007749 ABC-ATPase subunit interface; other site 1072459007750 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1072459007751 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1072459007752 dimer interface [polypeptide binding]; other site 1072459007753 conserved gate region; other site 1072459007754 putative PBP binding loops; other site 1072459007755 ABC-ATPase subunit interface; other site 1072459007756 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 1072459007757 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1072459007758 substrate binding pocket [chemical binding]; other site 1072459007759 membrane-bound complex binding site; other site 1072459007760 hinge residues; other site 1072459007761 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 1072459007762 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1072459007763 substrate binding pocket [chemical binding]; other site 1072459007764 membrane-bound complex binding site; other site 1072459007765 hinge residues; other site 1072459007766 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 1072459007767 Flavoprotein; Region: Flavoprotein; pfam02441 1072459007768 amidophosphoribosyltransferase; Provisional; Region: PRK09246 1072459007769 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1072459007770 active site 1072459007771 tetramer interface [polypeptide binding]; other site 1072459007772 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1072459007773 active site 1072459007774 colicin V production protein; Provisional; Region: PRK10845 1072459007775 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1072459007776 cell division protein DedD; Provisional; Region: PRK11633 1072459007777 Sporulation related domain; Region: SPOR; pfam05036 1072459007778 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 1072459007779 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1072459007780 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1072459007781 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1072459007782 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1072459007783 hypothetical protein; Provisional; Region: PRK10847 1072459007784 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1072459007785 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1072459007786 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1072459007787 dimerization interface 3.5A [polypeptide binding]; other site 1072459007788 active site 1072459007789 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 1072459007790 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1072459007791 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 1072459007792 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 1072459007793 ligand binding site [chemical binding]; other site 1072459007794 NAD binding site [chemical binding]; other site 1072459007795 catalytic site [active] 1072459007796 homodimer interface [polypeptide binding]; other site 1072459007797 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 1072459007798 putative transporter; Provisional; Region: PRK12382 1072459007799 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459007800 putative substrate translocation pore; other site 1072459007801 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 1072459007802 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1072459007803 dimer interface [polypeptide binding]; other site 1072459007804 active site 1072459007805 Uncharacterized conserved protein [Function unknown]; Region: COG4121 1072459007806 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 1072459007807 YfcL protein; Region: YfcL; pfam08891 1072459007808 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 1072459007809 hypothetical protein; Provisional; Region: PRK10621 1072459007810 Predicted permeases [General function prediction only]; Region: COG0730 1072459007811 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 1072459007812 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 1072459007813 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1072459007814 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1072459007815 Tetramer interface [polypeptide binding]; other site 1072459007816 active site 1072459007817 FMN-binding site [chemical binding]; other site 1072459007818 HemK family putative methylases; Region: hemK_fam; TIGR00536 1072459007819 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1072459007820 S-adenosylmethionine binding site [chemical binding]; other site 1072459007821 hypothetical protein; Provisional; Region: PRK04946 1072459007822 Smr domain; Region: Smr; pfam01713 1072459007823 Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950 1072459007824 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1072459007825 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1072459007826 Walker A/P-loop; other site 1072459007827 Walker A/P-loop; other site 1072459007828 ATP binding site [chemical binding]; other site 1072459007829 ATP binding site [chemical binding]; other site 1072459007830 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1072459007831 ABC transporter signature motif; other site 1072459007832 Walker B; other site 1072459007833 D-loop; other site 1072459007834 H-loop/switch region; other site 1072459007835 TIGR02646 family protein; Region: TIGR02646 1072459007836 Protein of unknown function (DUF2544); Region: DUF2544; pfam11245 1072459007837 Fimbrial protein; Region: Fimbrial; cl01416 1072459007838 Fimbrial protein; Region: Fimbrial; cl01416 1072459007839 Fimbrial protein; Region: Fimbrial; cl01416 1072459007840 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1072459007841 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1072459007842 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 1072459007843 PapC N-terminal domain; Region: PapC_N; pfam13954 1072459007844 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1072459007845 PapC C-terminal domain; Region: PapC_C; pfam13953 1072459007846 Fimbrial protein; Region: Fimbrial; cl01416 1072459007847 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1072459007848 catalytic core [active] 1072459007849 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 1072459007850 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1072459007851 substrate binding site [chemical binding]; other site 1072459007852 oxyanion hole (OAH) forming residues; other site 1072459007853 trimer interface [polypeptide binding]; other site 1072459007854 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1072459007855 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1072459007856 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 1072459007857 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1072459007858 dimer interface [polypeptide binding]; other site 1072459007859 active site 1072459007860 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 1072459007861 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 1072459007862 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 1072459007863 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 1072459007864 integrase; Provisional; Region: PRK09692 1072459007865 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1072459007866 active site 1072459007867 Int/Topo IB signature motif; other site 1072459007868 putative transposase OrfB; Reviewed; Region: PHA02517 1072459007869 HTH-like domain; Region: HTH_21; pfam13276 1072459007870 Integrase core domain; Region: rve; pfam00665 1072459007871 Integrase core domain; Region: rve_3; pfam13683 1072459007872 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1072459007873 active site 1072459007874 DNA binding site [nucleotide binding] 1072459007875 Int/Topo IB signature motif; other site 1072459007876 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 1072459007877 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1072459007878 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1072459007879 dimerization interface [polypeptide binding]; other site 1072459007880 substrate binding pocket [chemical binding]; other site 1072459007881 permease DsdX; Provisional; Region: PRK09921 1072459007882 gluconate transporter; Region: gntP; TIGR00791 1072459007883 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 1072459007884 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1072459007885 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1072459007886 catalytic residue [active] 1072459007887 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1072459007888 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459007889 putative substrate translocation pore; other site 1072459007890 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459007891 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1072459007892 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1072459007893 HlyD family secretion protein; Region: HlyD_3; pfam13437 1072459007894 DNA-binding transcriptional activator EvgA; Provisional; Region: PRK09958 1072459007895 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1072459007896 active site 1072459007897 phosphorylation site [posttranslational modification] 1072459007898 intermolecular recognition site; other site 1072459007899 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1072459007900 DNA binding residues [nucleotide binding] 1072459007901 dimerization interface [polypeptide binding]; other site 1072459007902 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 1072459007903 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1072459007904 substrate binding pocket [chemical binding]; other site 1072459007905 membrane-bound complex binding site; other site 1072459007906 hinge residues; other site 1072459007907 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1072459007908 substrate binding pocket [chemical binding]; other site 1072459007909 membrane-bound complex binding site; other site 1072459007910 hinge residues; other site 1072459007911 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1072459007912 dimer interface [polypeptide binding]; other site 1072459007913 phosphorylation site [posttranslational modification] 1072459007914 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1072459007915 ATP binding site [chemical binding]; other site 1072459007916 Mg2+ binding site [ion binding]; other site 1072459007917 G-X-G motif; other site 1072459007918 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1072459007919 active site 1072459007920 phosphorylation site [posttranslational modification] 1072459007921 intermolecular recognition site; other site 1072459007922 dimerization interface [polypeptide binding]; other site 1072459007923 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1072459007924 putative binding surface; other site 1072459007925 active site 1072459007926 putative CoA-transferase; Provisional; Region: PRK11430 1072459007927 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1072459007928 putative transporter YfdV; Provisional; Region: PRK09903 1072459007929 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 1072459007930 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1072459007931 PYR/PP interface [polypeptide binding]; other site 1072459007932 dimer interface [polypeptide binding]; other site 1072459007933 TPP binding site [chemical binding]; other site 1072459007934 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1072459007935 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 1072459007936 TPP-binding site; other site 1072459007937 dimer interface [polypeptide binding]; other site 1072459007938 formyl-coenzyme A transferase; Provisional; Region: PRK05398 1072459007939 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1072459007940 hypothetical protein; Provisional; Region: PRK10316 1072459007941 YfdX protein; Region: YfdX; pfam10938 1072459007942 Protein of unknown function (DUF2545); Region: DUF2545; pfam10810 1072459007943 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1072459007944 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1072459007945 putative acyl-acceptor binding pocket; other site 1072459007946 aminotransferase; Validated; Region: PRK08175 1072459007947 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1072459007948 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1072459007949 homodimer interface [polypeptide binding]; other site 1072459007950 catalytic residue [active] 1072459007951 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1072459007952 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1072459007953 GAF domain; Region: GAF; pfam01590 1072459007954 Histidine kinase; Region: His_kinase; pfam06580 1072459007955 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1072459007956 ATP binding site [chemical binding]; other site 1072459007957 Mg2+ binding site [ion binding]; other site 1072459007958 G-X-G motif; other site 1072459007959 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1072459007960 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1072459007961 active site 1072459007962 phosphorylation site [posttranslational modification] 1072459007963 intermolecular recognition site; other site 1072459007964 dimerization interface [polypeptide binding]; other site 1072459007965 LytTr DNA-binding domain; Region: LytTR; pfam04397 1072459007966 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1072459007967 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1072459007968 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1072459007969 dimerization domain swap beta strand [polypeptide binding]; other site 1072459007970 regulatory protein interface [polypeptide binding]; other site 1072459007971 active site 1072459007972 regulatory phosphorylation site [posttranslational modification]; other site 1072459007973 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1072459007974 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1072459007975 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1072459007976 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1072459007977 exoaminopeptidase; Provisional; Region: PRK09961 1072459007978 M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638 1072459007979 oligomer interface [polypeptide binding]; other site 1072459007980 active site 1072459007981 metal binding site [ion binding]; metal-binding site 1072459007982 aminopeptidase; Provisional; Region: PRK09795 1072459007983 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1072459007984 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1072459007985 active site 1072459007986 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1072459007987 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1072459007988 active site 1072459007989 P-loop; other site 1072459007990 phosphorylation site [posttranslational modification] 1072459007991 glucokinase, proteobacterial type; Region: glk; TIGR00749 1072459007992 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1072459007993 nucleotide binding site [chemical binding]; other site 1072459007994 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1072459007995 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1072459007996 Cl- selectivity filter; other site 1072459007997 Cl- binding residues [ion binding]; other site 1072459007998 pore gating glutamate residue; other site 1072459007999 dimer interface [polypeptide binding]; other site 1072459008000 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 1072459008001 manganese transport protein MntH; Reviewed; Region: PRK00701 1072459008002 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1072459008003 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1072459008004 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1072459008005 Nucleoside recognition; Region: Gate; pfam07670 1072459008006 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1072459008007 MASE1; Region: MASE1; pfam05231 1072459008008 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1072459008009 diguanylate cyclase; Region: GGDEF; smart00267 1072459008010 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1072459008011 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 1072459008012 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1072459008013 salt bridge; other site 1072459008014 non-specific DNA binding site [nucleotide binding]; other site 1072459008015 sequence-specific DNA binding site [nucleotide binding]; other site 1072459008016 potential frameshift: common BLAST hit: gi|378712630|ref|YP_005277523.1| transposase, IS605 OrfB family 1072459008017 Probable transposase; Region: OrfB_IS605; pfam01385 1072459008018 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1072459008019 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 1072459008020 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1072459008021 Transposase IS200 like; Region: Y1_Tnp; cl00848 1072459008022 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 1072459008023 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1072459008024 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1072459008025 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1072459008026 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1072459008027 active site 1072459008028 HIGH motif; other site 1072459008029 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1072459008030 active site 1072459008031 KMSKS motif; other site 1072459008032 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1072459008033 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1072459008034 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 1072459008035 putative dimerization interface [polypeptide binding]; other site 1072459008036 putative substrate binding pocket [chemical binding]; other site 1072459008037 nucleoside transporter; Region: 2A0110; TIGR00889 1072459008038 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1072459008039 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 1072459008040 nucleoside transporter; Region: 2A0110; TIGR00889 1072459008041 hypothetical protein; Provisional; Region: PRK11528 1072459008042 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1072459008043 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 1072459008044 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 1072459008045 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1072459008046 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1072459008047 nucleotide binding pocket [chemical binding]; other site 1072459008048 K-X-D-G motif; other site 1072459008049 catalytic site [active] 1072459008050 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1072459008051 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1072459008052 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1072459008053 Dimer interface [polypeptide binding]; other site 1072459008054 BRCT sequence motif; other site 1072459008055 cell division protein ZipA; Provisional; Region: PRK03427 1072459008056 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 1072459008057 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 1072459008058 FtsZ protein binding site [polypeptide binding]; other site 1072459008059 putative sulfate transport protein CysZ; Validated; Region: PRK04949 1072459008060 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1072459008061 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1072459008062 dimer interface [polypeptide binding]; other site 1072459008063 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1072459008064 catalytic residue [active] 1072459008065 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1072459008066 dimerization domain swap beta strand [polypeptide binding]; other site 1072459008067 regulatory protein interface [polypeptide binding]; other site 1072459008068 active site 1072459008069 regulatory phosphorylation site [posttranslational modification]; other site 1072459008070 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 1072459008071 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1072459008072 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1072459008073 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1072459008074 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1072459008075 HPr interaction site; other site 1072459008076 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1072459008077 active site 1072459008078 phosphorylation site [posttranslational modification] 1072459008079 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1072459008080 dimer interface [polypeptide binding]; other site 1072459008081 pyridoxamine kinase; Validated; Region: PRK05756 1072459008082 pyridoxal binding site [chemical binding]; other site 1072459008083 ATP binding site [chemical binding]; other site 1072459008084 hypothetical protein; Provisional; Region: PRK10318 1072459008085 cysteine synthase B; Region: cysM; TIGR01138 1072459008086 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1072459008087 dimer interface [polypeptide binding]; other site 1072459008088 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1072459008089 catalytic residue [active] 1072459008090 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 1072459008091 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1072459008092 Walker A/P-loop; other site 1072459008093 ATP binding site [chemical binding]; other site 1072459008094 Q-loop/lid; other site 1072459008095 ABC transporter signature motif; other site 1072459008096 Walker B; other site 1072459008097 D-loop; other site 1072459008098 H-loop/switch region; other site 1072459008099 TOBE-like domain; Region: TOBE_3; pfam12857 1072459008100 sulfate transport protein; Provisional; Region: cysT; CHL00187 1072459008101 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1072459008102 dimer interface [polypeptide binding]; other site 1072459008103 conserved gate region; other site 1072459008104 putative PBP binding loops; other site 1072459008105 ABC-ATPase subunit interface; other site 1072459008106 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1072459008107 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1072459008108 dimer interface [polypeptide binding]; other site 1072459008109 conserved gate region; other site 1072459008110 putative PBP binding loops; other site 1072459008111 ABC-ATPase subunit interface; other site 1072459008112 thiosulfate transporter subunit; Provisional; Region: PRK10852 1072459008113 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1072459008114 short chain dehydrogenase; Provisional; Region: PRK08226 1072459008115 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 1072459008116 NAD binding site [chemical binding]; other site 1072459008117 homotetramer interface [polypeptide binding]; other site 1072459008118 homodimer interface [polypeptide binding]; other site 1072459008119 active site 1072459008120 transcriptional regulator MurR; Provisional; Region: PRK15482 1072459008121 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1072459008122 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1072459008123 putative active site [active] 1072459008124 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1072459008125 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1072459008126 putative active site [active] 1072459008127 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 1072459008128 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1072459008129 active site turn [active] 1072459008130 phosphorylation site [posttranslational modification] 1072459008131 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1072459008132 putative periplasmic esterase; Provisional; Region: PRK03642 1072459008133 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1072459008134 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 1072459008135 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 1072459008136 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 1072459008137 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 1072459008138 putative acetyltransferase; Provisional; Region: PRK03624 1072459008139 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1072459008140 Coenzyme A binding pocket [chemical binding]; other site 1072459008141 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 1072459008142 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1072459008143 active site 1072459008144 metal binding site [ion binding]; metal-binding site 1072459008145 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 1072459008146 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 1072459008147 transcriptional regulator EutR; Provisional; Region: PRK10130 1072459008148 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1072459008149 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1072459008150 carboxysome structural protein EutK; Provisional; Region: PRK15466 1072459008151 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 1072459008152 Hexamer interface [polypeptide binding]; other site 1072459008153 Hexagonal pore residue; other site 1072459008154 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 1072459008155 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 1072459008156 putative hexamer interface [polypeptide binding]; other site 1072459008157 putative hexagonal pore; other site 1072459008158 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 1072459008159 putative hexamer interface [polypeptide binding]; other site 1072459008160 putative hexagonal pore; other site 1072459008161 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 1072459008162 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 1072459008163 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 1072459008164 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 1072459008165 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 1072459008166 ethanol dehydrogenase EutG; Provisional; Region: PRK15454 1072459008167 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 1072459008168 active site 1072459008169 metal binding site [ion binding]; metal-binding site 1072459008170 ethanolamine utilization protein EutJ; Provisional; Region: PRK15080 1072459008171 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1072459008172 nucleotide binding site [chemical binding]; other site 1072459008173 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 1072459008174 putative catalytic cysteine [active] 1072459008175 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 1072459008176 Hexamer/Pentamer interface [polypeptide binding]; other site 1072459008177 central pore; other site 1072459008178 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1072459008179 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 1072459008180 Hexamer interface [polypeptide binding]; other site 1072459008181 Putative hexagonal pore residue; other site 1072459008182 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1072459008183 ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020 1072459008184 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 1072459008185 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766 1072459008186 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1072459008187 G1 box; other site 1072459008188 GTP/Mg2+ binding site [chemical binding]; other site 1072459008189 G2 box; other site 1072459008190 Switch I region; other site 1072459008191 G3 box; other site 1072459008192 Switch II region; other site 1072459008193 G4 box; other site 1072459008194 G5 box; other site 1072459008195 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 1072459008196 putative hexamer interface [polypeptide binding]; other site 1072459008197 putative hexagonal pore; other site 1072459008198 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 1072459008199 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1072459008200 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1072459008201 putative NAD(P) binding site [chemical binding]; other site 1072459008202 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 1072459008203 transaldolase-like protein; Provisional; Region: PTZ00411 1072459008204 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1072459008205 active site 1072459008206 dimer interface [polypeptide binding]; other site 1072459008207 catalytic residue [active] 1072459008208 transketolase; Reviewed; Region: PRK12753 1072459008209 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1072459008210 TPP-binding site [chemical binding]; other site 1072459008211 dimer interface [polypeptide binding]; other site 1072459008212 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1072459008213 PYR/PP interface [polypeptide binding]; other site 1072459008214 dimer interface [polypeptide binding]; other site 1072459008215 TPP binding site [chemical binding]; other site 1072459008216 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1072459008217 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 1072459008218 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 1072459008219 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1072459008220 dimer interface [polypeptide binding]; other site 1072459008221 ADP-ribose binding site [chemical binding]; other site 1072459008222 active site 1072459008223 nudix motif; other site 1072459008224 metal binding site [ion binding]; metal-binding site 1072459008225 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 1072459008226 4Fe-4S binding domain; Region: Fer4; pfam00037 1072459008227 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1072459008228 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1072459008229 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 1072459008230 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1072459008231 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1072459008232 dimerization interface [polypeptide binding]; other site 1072459008233 Histidine kinase; Region: HisKA_3; pfam07730 1072459008234 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1072459008235 ATP binding site [chemical binding]; other site 1072459008236 Mg2+ binding site [ion binding]; other site 1072459008237 G-X-G motif; other site 1072459008238 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 1072459008239 Protein export membrane protein; Region: SecD_SecF; cl14618 1072459008240 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 1072459008241 ArsC family; Region: ArsC; pfam03960 1072459008242 putative catalytic residues [active] 1072459008243 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 1072459008244 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 1072459008245 metal binding site [ion binding]; metal-binding site 1072459008246 dimer interface [polypeptide binding]; other site 1072459008247 hypothetical protein; Provisional; Region: PRK13664 1072459008248 putative hydrolase; Provisional; Region: PRK11460 1072459008249 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 1072459008250 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 1072459008251 Helicase; Region: Helicase_RecD; pfam05127 1072459008252 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 1072459008253 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 1072459008254 Predicted metalloprotease [General function prediction only]; Region: COG2321 1072459008255 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1072459008256 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1072459008257 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1072459008258 ATP binding site [chemical binding]; other site 1072459008259 active site 1072459008260 substrate binding site [chemical binding]; other site 1072459008261 lipoprotein; Provisional; Region: PRK11679 1072459008262 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 1072459008263 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1072459008264 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1072459008265 dimer interface [polypeptide binding]; other site 1072459008266 active site 1072459008267 catalytic residue [active] 1072459008268 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 1072459008269 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 1072459008270 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1072459008271 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1072459008272 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1072459008273 catalytic triad [active] 1072459008274 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 1072459008275 4Fe-4S binding domain; Region: Fer4; pfam00037 1072459008276 hydrogenase 4 subunit B; Validated; Region: PRK06521 1072459008277 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1072459008278 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1072459008279 NADH dehydrogenase; Region: NADHdh; cl00469 1072459008280 hydrogenase 4 subunit D; Validated; Region: PRK06525 1072459008281 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1072459008282 hydrogenase 4 membrane subunit; Provisional; Region: hyfE; PRK11492 1072459008283 hydrogenase 4 subunit F; Validated; Region: PRK06458 1072459008284 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1072459008285 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 1072459008286 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 1072459008287 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1072459008288 hydrogenase 4 subunit H; Validated; Region: PRK08222 1072459008289 4Fe-4S binding domain; Region: Fer4; pfam00037 1072459008290 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 1072459008291 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 1072459008292 putative formate transporter; Provisional; Region: focB; PRK09713 1072459008293 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1072459008294 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1072459008295 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 1072459008296 Peptidase family M48; Region: Peptidase_M48; cl12018 1072459008297 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1072459008298 ArsC family; Region: ArsC; pfam03960 1072459008299 catalytic residues [active] 1072459008300 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 1072459008301 DNA replication initiation factor; Provisional; Region: PRK08084 1072459008302 uracil transporter; Provisional; Region: PRK10720 1072459008303 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1072459008304 active site 1072459008305 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1072459008306 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1072459008307 dimerization interface [polypeptide binding]; other site 1072459008308 putative ATP binding site [chemical binding]; other site 1072459008309 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1072459008310 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1072459008311 active site 1072459008312 substrate binding site [chemical binding]; other site 1072459008313 cosubstrate binding site; other site 1072459008314 catalytic site [active] 1072459008315 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 1072459008316 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1072459008317 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1072459008318 Catalytic C-terminal domain, first repeat, of prokaryotic polyphosphate kinase 1 and similar proteins; Region: PLDc_PPK1_C1; cd09114 1072459008319 domain interface [polypeptide binding]; other site 1072459008320 active site 1072459008321 catalytic site [active] 1072459008322 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1072459008323 putative active site [active] 1072459008324 catalytic site [active] 1072459008325 exopolyphosphatase; Provisional; Region: PRK10854 1072459008326 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1072459008327 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 1072459008328 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 1072459008329 putative transposase OrfB; Reviewed; Region: PHA02517 1072459008330 HTH-like domain; Region: HTH_21; pfam13276 1072459008331 Integrase core domain; Region: rve; pfam00665 1072459008332 Integrase core domain; Region: rve_3; pfam13683 1072459008333 Protein of unknown function (DUF2514); Region: DUF2514; pfam10721 1072459008334 Predicted chitinase [General function prediction only]; Region: COG3179 1072459008335 catalytic residue [active] 1072459008336 N terminal extension of bacteriophage endosialidase; Region: End_N_terminal; pfam12218 1072459008337 Catalytic beta propeller domain of bacteriophage endosialidase; Region: End_beta_propel; cl12167 1072459008338 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 1072459008339 Asp-box motif; other site 1072459008340 catalytic site [active] 1072459008341 Catalytic domain of bacteriophage endosialidase; Region: End_tail_spike; pfam12219 1072459008342 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 1072459008343 structural protein; Region: PHA01972 1072459008344 virion protein; Provisional; Region: V; PHA02564 1072459008345 hypothetical protein; Region: PHA01733 1072459008346 hypothetical protein; Region: PHA00661 1072459008347 hypothetical protein; Region: PHA00662 1072459008348 hypothetical protein; Region: PHA00669 1072459008349 hypothetical protein; Region: PHA00664 1072459008350 major capsid protein; Region: PHA00665 1072459008351 putative protease; Region: PHA00666 1072459008352 hypothetical protein; Region: PHA00670 1072459008353 Bacteriophage head to tail connecting protein; Region: Head-tail_con; pfam12236 1072459008354 Terminase small subunit; Region: Terminase_2; pfam03592 1072459008355 Protein of unknown function (DUF551); Region: DUF551; pfam04448 1072459008356 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 1072459008357 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 1072459008358 Replication protein P; Region: Phage_lambda_P; pfam06992 1072459008359 Pyocin large subunit [General function prediction only]; Region: COG5529 1072459008360 Helix-turn-helix domain; Region: HTH_36; pfam13730 1072459008361 primosomal protein DnaI; Provisional; Region: PRK02854 1072459008362 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1072459008363 sequence-specific DNA binding site [nucleotide binding]; other site 1072459008364 salt bridge; other site 1072459008365 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 1072459008366 recombination and repair protein RecT; Reviewed; Region: recT; PRK09846 1072459008367 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 1072459008368 MT-A70; Region: MT-A70; cl01947 1072459008369 Protein of unknown function (DUF1382); Region: DUF1382; pfam07131 1072459008370 integrase; Provisional; Region: PRK09692 1072459008371 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1072459008372 active site 1072459008373 Int/Topo IB signature motif; other site 1072459008374 GMP synthase; Reviewed; Region: guaA; PRK00074 1072459008375 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1072459008376 AMP/PPi binding site [chemical binding]; other site 1072459008377 candidate oxyanion hole; other site 1072459008378 catalytic triad [active] 1072459008379 potential glutamine specificity residues [chemical binding]; other site 1072459008380 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1072459008381 ATP Binding subdomain [chemical binding]; other site 1072459008382 Ligand Binding sites [chemical binding]; other site 1072459008383 Dimerization subdomain; other site 1072459008384 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1072459008385 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1072459008386 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1072459008387 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1072459008388 active site 1072459008389 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 1072459008390 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1072459008391 generic binding surface II; other site 1072459008392 generic binding surface I; other site 1072459008393 RatA-like protein; Provisional; Region: PRK15316 1072459008394 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1072459008395 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1072459008396 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1072459008397 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1072459008398 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1072459008399 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1072459008400 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1072459008401 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1072459008402 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1072459008403 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1072459008404 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1072459008405 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1072459008406 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1072459008407 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1072459008408 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1072459008409 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1072459008410 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1072459008411 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1072459008412 intimin-like protein SinH; Provisional; Region: PRK15318 1072459008413 intimin-like protein SinH; Provisional; Region: PRK15318 1072459008414 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 1072459008415 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 1072459008416 GTP-binding protein Der; Reviewed; Region: PRK00093 1072459008417 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1072459008418 G1 box; other site 1072459008419 GTP/Mg2+ binding site [chemical binding]; other site 1072459008420 Switch I region; other site 1072459008421 G2 box; other site 1072459008422 Switch II region; other site 1072459008423 G3 box; other site 1072459008424 G4 box; other site 1072459008425 G5 box; other site 1072459008426 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1072459008427 G1 box; other site 1072459008428 GTP/Mg2+ binding site [chemical binding]; other site 1072459008429 Switch I region; other site 1072459008430 G2 box; other site 1072459008431 G3 box; other site 1072459008432 Switch II region; other site 1072459008433 G4 box; other site 1072459008434 G5 box; other site 1072459008435 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 1072459008436 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cd00216 1072459008437 Trp docking motif [polypeptide binding]; other site 1072459008438 active site 1072459008439 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 1072459008440 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 1072459008441 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1072459008442 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1072459008443 dimer interface [polypeptide binding]; other site 1072459008444 motif 1; other site 1072459008445 active site 1072459008446 motif 2; other site 1072459008447 motif 3; other site 1072459008448 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1072459008449 anticodon binding site; other site 1072459008450 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1072459008451 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1072459008452 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1072459008453 cytoskeletal protein RodZ; Provisional; Region: PRK10856 1072459008454 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1072459008455 non-specific DNA binding site [nucleotide binding]; other site 1072459008456 salt bridge; other site 1072459008457 sequence-specific DNA binding site [nucleotide binding]; other site 1072459008458 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1072459008459 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 1072459008460 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1072459008461 FeS/SAM binding site; other site 1072459008462 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1072459008463 active site 1072459008464 multimer interface [polypeptide binding]; other site 1072459008465 penicillin-binding protein 1C; Provisional; Region: PRK11240 1072459008466 Transglycosylase; Region: Transgly; pfam00912 1072459008467 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1072459008468 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 1072459008469 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 1072459008470 MG2 domain; Region: A2M_N; pfam01835 1072459008471 Alpha-2-macroglobulin family; Region: A2M; pfam00207 1072459008472 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 1072459008473 surface patch; other site 1072459008474 thioester region; other site 1072459008475 specificity defining residues; other site 1072459008476 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 1072459008477 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1072459008478 active site residue [active] 1072459008479 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1072459008480 active site residue [active] 1072459008481 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 1072459008482 aminopeptidase B; Provisional; Region: PRK05015 1072459008483 Peptidase; Region: DUF3663; pfam12404 1072459008484 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1072459008485 interface (dimer of trimers) [polypeptide binding]; other site 1072459008486 Substrate-binding/catalytic site; other site 1072459008487 Zn-binding sites [ion binding]; other site 1072459008488 hypothetical protein; Provisional; Region: PRK10721 1072459008489 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1072459008490 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1072459008491 catalytic loop [active] 1072459008492 iron binding site [ion binding]; other site 1072459008493 chaperone protein HscA; Provisional; Region: hscA; PRK05183 1072459008494 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 1072459008495 nucleotide binding site [chemical binding]; other site 1072459008496 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1072459008497 SBD interface [polypeptide binding]; other site 1072459008498 co-chaperone HscB; Provisional; Region: hscB; PRK05014 1072459008499 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1072459008500 HSP70 interaction site [polypeptide binding]; other site 1072459008501 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 1072459008502 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 1072459008503 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1072459008504 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1072459008505 trimerization site [polypeptide binding]; other site 1072459008506 active site 1072459008507 cysteine desulfurase; Provisional; Region: PRK14012 1072459008508 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1072459008509 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1072459008510 catalytic residue [active] 1072459008511 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 1072459008512 Rrf2 family protein; Region: rrf2_super; TIGR00738 1072459008513 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 1072459008514 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1072459008515 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1072459008516 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1072459008517 active site 1072459008518 dimerization interface [polypeptide binding]; other site 1072459008519 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1072459008520 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1072459008521 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 1072459008522 PRD domain; Region: PRD; pfam00874 1072459008523 PRD domain; Region: PRD; pfam00874 1072459008524 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 1072459008525 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459008526 putative substrate translocation pore; other site 1072459008527 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1072459008528 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1072459008529 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1072459008530 dimerization interface [polypeptide binding]; other site 1072459008531 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1072459008532 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1072459008533 iron-sulfur cluster [ion binding]; other site 1072459008534 [2Fe-2S] cluster binding site [ion binding]; other site 1072459008535 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 1072459008536 beta subunit interface [polypeptide binding]; other site 1072459008537 alpha subunit interface [polypeptide binding]; other site 1072459008538 active site 1072459008539 substrate binding site [chemical binding]; other site 1072459008540 Fe binding site [ion binding]; other site 1072459008541 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 1072459008542 inter-subunit interface; other site 1072459008543 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 1072459008544 [2Fe-2S] cluster binding site [ion binding]; other site 1072459008545 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 1072459008546 cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase (BphB)-like, classical (c) SDRs; Region: BphB-like_SDR_c; cd05348 1072459008547 NAD binding site [chemical binding]; other site 1072459008548 active site 1072459008549 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1072459008550 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1072459008551 Predicted membrane protein [Function unknown]; Region: COG2259 1072459008552 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 1072459008553 active site 1072459008554 catalytic residues [active] 1072459008555 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1072459008556 L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239 1072459008557 putative NAD(P) binding site [chemical binding]; other site 1072459008558 catalytic Zn binding site [ion binding]; other site 1072459008559 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1072459008560 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1072459008561 TM-ABC transporter signature motif; other site 1072459008562 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1072459008563 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1072459008564 Walker A/P-loop; other site 1072459008565 ATP binding site [chemical binding]; other site 1072459008566 Q-loop/lid; other site 1072459008567 ABC transporter signature motif; other site 1072459008568 Walker B; other site 1072459008569 D-loop; other site 1072459008570 H-loop/switch region; other site 1072459008571 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1072459008572 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1072459008573 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1072459008574 ligand binding site [chemical binding]; other site 1072459008575 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1072459008576 TPR motif; other site 1072459008577 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1072459008578 binding surface 1072459008579 TPR repeat; Region: TPR_11; pfam13414 1072459008580 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1072459008581 TPR motif; other site 1072459008582 binding surface 1072459008583 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1072459008584 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1072459008585 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1072459008586 nucleotide binding site [chemical binding]; other site 1072459008587 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1072459008588 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1072459008589 dimer interface [polypeptide binding]; other site 1072459008590 active site 1072459008591 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1072459008592 folate binding site [chemical binding]; other site 1072459008593 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1072459008594 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1072459008595 heme-binding site [chemical binding]; other site 1072459008596 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1072459008597 FAD binding pocket [chemical binding]; other site 1072459008598 FAD binding motif [chemical binding]; other site 1072459008599 phosphate binding motif [ion binding]; other site 1072459008600 beta-alpha-beta structure motif; other site 1072459008601 NAD binding pocket [chemical binding]; other site 1072459008602 Heme binding pocket [chemical binding]; other site 1072459008603 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 1072459008604 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1072459008605 response regulator GlrR; Provisional; Region: PRK15115 1072459008606 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1072459008607 active site 1072459008608 phosphorylation site [posttranslational modification] 1072459008609 intermolecular recognition site; other site 1072459008610 dimerization interface [polypeptide binding]; other site 1072459008611 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1072459008612 Walker A motif; other site 1072459008613 ATP binding site [chemical binding]; other site 1072459008614 Walker B motif; other site 1072459008615 arginine finger; other site 1072459008616 hypothetical protein; Provisional; Region: PRK10722 1072459008617 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1072459008618 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1072459008619 dimer interface [polypeptide binding]; other site 1072459008620 phosphorylation site [posttranslational modification] 1072459008621 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1072459008622 ATP binding site [chemical binding]; other site 1072459008623 Mg2+ binding site [ion binding]; other site 1072459008624 G-X-G motif; other site 1072459008625 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 1072459008626 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1072459008627 dimerization interface [polypeptide binding]; other site 1072459008628 ATP binding site [chemical binding]; other site 1072459008629 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 1072459008630 dimerization interface [polypeptide binding]; other site 1072459008631 ATP binding site [chemical binding]; other site 1072459008632 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1072459008633 putative active site [active] 1072459008634 catalytic triad [active] 1072459008635 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 1072459008636 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1072459008637 substrate binding pocket [chemical binding]; other site 1072459008638 membrane-bound complex binding site; other site 1072459008639 hinge residues; other site 1072459008640 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1072459008641 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1072459008642 catalytic residue [active] 1072459008643 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1072459008644 nucleoside/Zn binding site; other site 1072459008645 dimer interface [polypeptide binding]; other site 1072459008646 catalytic motif [active] 1072459008647 hypothetical protein; Provisional; Region: PRK11590 1072459008648 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1072459008649 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1072459008650 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 1072459008651 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1072459008652 putative active site [active] 1072459008653 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1072459008654 holo-[acyl-carrier-protein] synthase; Region: acpS; TIGR00516 1072459008655 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 1072459008656 active site 1072459008657 hydrophilic channel; other site 1072459008658 dimerization interface [polypeptide binding]; other site 1072459008659 catalytic residues [active] 1072459008660 active site lid [active] 1072459008661 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1072459008662 Recombination protein O N terminal; Region: RecO_N; pfam11967 1072459008663 Recombination protein O C terminal; Region: RecO_C; pfam02565 1072459008664 GTPase Era; Reviewed; Region: era; PRK00089 1072459008665 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1072459008666 G1 box; other site 1072459008667 GTP/Mg2+ binding site [chemical binding]; other site 1072459008668 Switch I region; other site 1072459008669 G2 box; other site 1072459008670 Switch II region; other site 1072459008671 G3 box; other site 1072459008672 G4 box; other site 1072459008673 G5 box; other site 1072459008674 KH domain; Region: KH_2; pfam07650 1072459008675 ribonuclease III; Reviewed; Region: rnc; PRK00102 1072459008676 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1072459008677 dimerization interface [polypeptide binding]; other site 1072459008678 active site 1072459008679 metal binding site [ion binding]; metal-binding site 1072459008680 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1072459008681 dsRNA binding site [nucleotide binding]; other site 1072459008682 signal peptidase I; Provisional; Region: PRK10861 1072459008683 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1072459008684 Catalytic site [active] 1072459008685 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1072459008686 GTP-binding protein LepA; Provisional; Region: PRK05433 1072459008687 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1072459008688 G1 box; other site 1072459008689 putative GEF interaction site [polypeptide binding]; other site 1072459008690 GTP/Mg2+ binding site [chemical binding]; other site 1072459008691 Switch I region; other site 1072459008692 G2 box; other site 1072459008693 G3 box; other site 1072459008694 Switch II region; other site 1072459008695 G4 box; other site 1072459008696 G5 box; other site 1072459008697 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1072459008698 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1072459008699 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1072459008700 SoxR reducing system protein RseC; Provisional; Region: PRK10862 1072459008701 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 1072459008702 anti-sigma E factor; Provisional; Region: rseB; PRK09455 1072459008703 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 1072459008704 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 1072459008705 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 1072459008706 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 1072459008707 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1072459008708 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1072459008709 DNA binding residues [nucleotide binding] 1072459008710 L-aspartate oxidase; Provisional; Region: PRK09077 1072459008711 L-aspartate oxidase; Provisional; Region: PRK06175 1072459008712 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1072459008713 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1072459008714 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1072459008715 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 1072459008716 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1072459008717 ATP binding site [chemical binding]; other site 1072459008718 Mg++ binding site [ion binding]; other site 1072459008719 motif III; other site 1072459008720 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1072459008721 nucleotide binding region [chemical binding]; other site 1072459008722 ATP-binding site [chemical binding]; other site 1072459008723 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1072459008724 Helix-turn-helix domain; Region: HTH_28; pfam13518 1072459008725 Helix-turn-helix domain; Region: HTH_28; pfam13518 1072459008726 Integrase core domain; Region: rve; pfam00665 1072459008727 Integrase core domain; Region: rve_2; pfam13333 1072459008728 cysteine/O-acetylserine exporter; Provisional; Region: PRK10323 1072459008729 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 1072459008730 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1072459008731 ligand binding site [chemical binding]; other site 1072459008732 active site 1072459008733 UGI interface [polypeptide binding]; other site 1072459008734 catalytic site [active] 1072459008735 putative methyltransferase; Provisional; Region: PRK10864 1072459008736 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1072459008737 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1072459008738 thioredoxin 2; Provisional; Region: PRK10996 1072459008739 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 1072459008740 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1072459008741 catalytic residues [active] 1072459008742 Uncharacterized conserved protein [Function unknown]; Region: COG3148 1072459008743 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 1072459008744 CoA binding domain; Region: CoA_binding_2; pfam13380 1072459008745 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1072459008746 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1072459008747 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1072459008748 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1072459008749 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 1072459008750 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 1072459008751 domain interface [polypeptide binding]; other site 1072459008752 putative active site [active] 1072459008753 catalytic site [active] 1072459008754 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 1072459008755 domain interface [polypeptide binding]; other site 1072459008756 putative active site [active] 1072459008757 catalytic site [active] 1072459008758 lipoprotein; Provisional; Region: PRK10759 1072459008759 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 1072459008760 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459008761 putative substrate translocation pore; other site 1072459008762 protein disaggregation chaperone; Provisional; Region: PRK10865 1072459008763 Clp amino terminal domain; Region: Clp_N; pfam02861 1072459008764 Clp amino terminal domain; Region: Clp_N; pfam02861 1072459008765 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1072459008766 Walker A motif; other site 1072459008767 ATP binding site [chemical binding]; other site 1072459008768 Walker B motif; other site 1072459008769 arginine finger; other site 1072459008770 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1072459008771 Walker A motif; other site 1072459008772 ATP binding site [chemical binding]; other site 1072459008773 Walker B motif; other site 1072459008774 arginine finger; other site 1072459008775 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1072459008776 hypothetical protein; Provisional; Region: PRK10723 1072459008777 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1072459008778 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 1072459008779 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1072459008780 RNA binding surface [nucleotide binding]; other site 1072459008781 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1072459008782 active site 1072459008783 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 1072459008784 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 1072459008785 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 1072459008786 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1072459008787 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1072459008788 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1072459008789 30S subunit binding site; other site 1072459008790 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 1072459008791 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 1072459008792 Prephenate dehydratase; Region: PDT; pfam00800 1072459008793 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1072459008794 putative L-Phe binding site [chemical binding]; other site 1072459008795 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 1072459008796 Chorismate mutase type II; Region: CM_2; cl00693 1072459008797 prephenate dehydrogenase; Validated; Region: PRK08507 1072459008798 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 1072459008799 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1072459008800 lipoprotein; Provisional; Region: PRK11443 1072459008801 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 1072459008802 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 1072459008803 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 1072459008804 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1072459008805 metal binding site [ion binding]; metal-binding site 1072459008806 active site 1072459008807 I-site; other site 1072459008808 putative outer membrane lipoprotein; Provisional; Region: PRK09967 1072459008809 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1072459008810 ligand binding site [chemical binding]; other site 1072459008811 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1072459008812 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1072459008813 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1072459008814 RimM N-terminal domain; Region: RimM; pfam01782 1072459008815 PRC-barrel domain; Region: PRC; pfam05239 1072459008816 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1072459008817 signal recognition particle protein; Provisional; Region: PRK10867 1072459008818 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1072459008819 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1072459008820 P loop; other site 1072459008821 GTP binding site [chemical binding]; other site 1072459008822 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1072459008823 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 1072459008824 hypothetical protein; Provisional; Region: PRK11573 1072459008825 Domain of unknown function DUF21; Region: DUF21; pfam01595 1072459008826 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1072459008827 Transporter associated domain; Region: CorC_HlyC; smart01091 1072459008828 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1072459008829 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1072459008830 dimer interface [polypeptide binding]; other site 1072459008831 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1072459008832 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 1072459008833 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 1072459008834 recombination and repair protein; Provisional; Region: PRK10869 1072459008835 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1072459008836 Walker A/P-loop; other site 1072459008837 ATP binding site [chemical binding]; other site 1072459008838 Q-loop/lid; other site 1072459008839 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1072459008840 Q-loop/lid; other site 1072459008841 ABC transporter signature motif; other site 1072459008842 Walker B; other site 1072459008843 D-loop; other site 1072459008844 H-loop/switch region; other site 1072459008845 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 1072459008846 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 1072459008847 hypothetical protein; Validated; Region: PRK01777 1072459008848 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 1072459008849 putative coenzyme Q binding site [chemical binding]; other site 1072459008850 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1072459008851 SmpB-tmRNA interface; other site 1072459008852 N-terminal domain of type IIE restriction endonuclease EcoRII and similar proteins; Region: EcoRII_N; cd10016 1072459008853 DNA binding site [nucleotide binding] 1072459008854 EcoRII C terminal; Region: EcoRII-C; pfam09019 1072459008855 DNA cytosine methylase; Provisional; Region: PRK10458 1072459008856 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1072459008857 cofactor binding site; other site 1072459008858 DNA binding site [nucleotide binding] 1072459008859 substrate interaction site [chemical binding]; other site 1072459008860 GIY-YIG domain of uncharacterized proteins from bacteria and their eukaryotic homologs; Region: GIY-YIG_COG3680; cd10440 1072459008861 GIY-YIG motif/motif A; other site 1072459008862 putative active site [active] 1072459008863 putative metal binding site [ion binding]; other site 1072459008864 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1072459008865 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1072459008866 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3778 1072459008867 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 1072459008868 Phage protein GP46; Region: GP46; pfam07409 1072459008869 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 1072459008870 Bacteriophage Mu Gp45 protein; Region: Phage_Mu_Gp45; pfam06890 1072459008871 Mu-like prophage tail protein gpP [General function prediction only]; Region: COG4379 1072459008872 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1072459008873 Mu-like prophage DNA circulation protein [General function prediction only]; Region: COG4228 1072459008874 DNA circulation protein N-terminus; Region: DNA_circ_N; pfam07157 1072459008875 CE10_3066; tail protein from Bacteriophage,fragment 1072459008876 putative transposase OrfB; Reviewed; Region: PHA02517 1072459008877 HTH-like domain; Region: HTH_21; pfam13276 1072459008878 Integrase core domain; Region: rve; pfam00665 1072459008879 Integrase core domain; Region: rve_3; pfam13683 1072459008880 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac1_AmyA; cd11315 1072459008881 active site 1072459008882 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1072459008883 Ca binding site [ion binding]; other site 1072459008884 catalytic site [active] 1072459008885 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1072459008886 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 1072459008887 substrate binding pocket [chemical binding]; other site 1072459008888 active site 1072459008889 iron coordination sites [ion binding]; other site 1072459008890 Predicted dehydrogenase [General function prediction only]; Region: COG0579 1072459008891 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1072459008892 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 1072459008893 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1072459008894 tetramerization interface [polypeptide binding]; other site 1072459008895 NAD(P) binding site [chemical binding]; other site 1072459008896 catalytic residues [active] 1072459008897 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 1072459008898 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1072459008899 inhibitor-cofactor binding pocket; inhibition site 1072459008900 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1072459008901 catalytic residue [active] 1072459008902 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 1072459008903 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 1072459008904 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1072459008905 DNA-binding site [nucleotide binding]; DNA binding site 1072459008906 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1072459008907 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 1072459008908 bacterial OsmY and nodulation domain; Region: BON; smart00749 1072459008909 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1072459008910 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 1072459008911 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1072459008912 dimerization interface [polypeptide binding]; other site 1072459008913 putative DNA binding site [nucleotide binding]; other site 1072459008914 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1072459008915 putative Zn2+ binding site [ion binding]; other site 1072459008916 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YgaP, and similar uncharacterized putative rhodanese-related sulfurtransferases; Region: RHOD_YgaP; cd01527 1072459008917 active site residue [active] 1072459008918 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1072459008919 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 1072459008920 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 1072459008921 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 1072459008922 hypothetical protein; Provisional; Region: PRK10556 1072459008923 hypothetical protein; Provisional; Region: PRK10132 1072459008924 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1072459008925 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1072459008926 DNA-binding site [nucleotide binding]; DNA binding site 1072459008927 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1072459008928 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1072459008929 homodimer interface [polypeptide binding]; other site 1072459008930 catalytic residue [active] 1072459008931 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1072459008932 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1072459008933 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1072459008934 catalytic residues [active] 1072459008935 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1072459008936 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 1072459008937 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1072459008938 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1072459008939 active site 1072459008940 dimer interface [polypeptide binding]; other site 1072459008941 catalytic residues [active] 1072459008942 effector binding site; other site 1072459008943 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1072459008944 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1072459008945 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1072459008946 dimer interface [polypeptide binding]; other site 1072459008947 putative radical transfer pathway; other site 1072459008948 diiron center [ion binding]; other site 1072459008949 tyrosyl radical; other site 1072459008950 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 1072459008951 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1072459008952 Walker A/P-loop; other site 1072459008953 ATP binding site [chemical binding]; other site 1072459008954 Q-loop/lid; other site 1072459008955 ABC transporter signature motif; other site 1072459008956 Walker B; other site 1072459008957 D-loop; other site 1072459008958 H-loop/switch region; other site 1072459008959 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1072459008960 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 1072459008961 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1072459008962 dimer interface [polypeptide binding]; other site 1072459008963 conserved gate region; other site 1072459008964 putative PBP binding loops; other site 1072459008965 ABC-ATPase subunit interface; other site 1072459008966 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 1072459008967 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1072459008968 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1072459008969 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459008970 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1072459008971 putative L-valine exporter; Provisional; Region: PRK10408 1072459008972 transcriptional repressor MprA; Provisional; Region: PRK10870 1072459008973 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1072459008974 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 1072459008975 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1072459008976 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1072459008977 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 1072459008978 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1072459008979 HlyD family secretion protein; Region: HlyD_3; pfam13437 1072459008980 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1072459008981 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459008982 putative substrate translocation pore; other site 1072459008983 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459008984 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1072459008985 glutamate--cysteine ligase; Provisional; Region: PRK02107 1072459008986 Predicted membrane protein [Function unknown]; Region: COG1238 1072459008987 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 1072459008988 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1072459008989 motif II; other site 1072459008990 carbon storage regulator; Provisional; Region: PRK01712 1072459008991 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1072459008992 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1072459008993 motif 1; other site 1072459008994 active site 1072459008995 motif 2; other site 1072459008996 motif 3; other site 1072459008997 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1072459008998 DHHA1 domain; Region: DHHA1; pfam02272 1072459008999 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1072459009000 recombinase A; Provisional; Region: recA; PRK09354 1072459009001 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1072459009002 hexamer interface [polypeptide binding]; other site 1072459009003 Walker A motif; other site 1072459009004 ATP binding site [chemical binding]; other site 1072459009005 Walker B motif; other site 1072459009006 hypothetical protein; Validated; Region: PRK03661 1072459009007 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1072459009008 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1072459009009 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1072459009010 PTS system, glucitol/sorbitol-specific, IIC component; Region: EII-GUT; TIGR00821 1072459009011 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 1072459009012 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 1072459009013 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 1072459009014 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 1072459009015 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 1072459009016 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 1072459009017 putative NAD(P) binding site [chemical binding]; other site 1072459009018 active site 1072459009019 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 1072459009020 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 1072459009021 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1072459009022 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1072459009023 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 1072459009024 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1072459009025 putative active site [active] 1072459009026 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1072459009027 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 1072459009028 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1072459009029 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1072459009030 Walker A motif; other site 1072459009031 ATP binding site [chemical binding]; other site 1072459009032 Walker B motif; other site 1072459009033 arginine finger; other site 1072459009034 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 1072459009035 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1072459009036 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1072459009037 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1072459009038 iron binding site [ion binding]; other site 1072459009039 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 1072459009040 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1072459009041 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 1072459009042 Acylphosphatase; Region: Acylphosphatase; pfam00708 1072459009043 HypF finger; Region: zf-HYPF; pfam07503 1072459009044 HypF finger; Region: zf-HYPF; pfam07503 1072459009045 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 1072459009046 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 1072459009047 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1072459009048 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1072459009049 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1072459009050 DNA binding site [nucleotide binding] 1072459009051 domain linker motif; other site 1072459009052 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1072459009053 dimerization interface (closed form) [polypeptide binding]; other site 1072459009054 ligand binding site [chemical binding]; other site 1072459009055 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 1072459009056 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1072459009057 active site turn [active] 1072459009058 phosphorylation site [posttranslational modification] 1072459009059 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 1072459009060 cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852 1072459009061 beta-galactosidase; Region: BGL; TIGR03356 1072459009062 Integrase core domain; Region: rve; pfam00665 1072459009063 Integrase core domain; Region: rve_2; pfam13333 1072459009064 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1072459009065 Helix-turn-helix domain; Region: HTH_28; pfam13518 1072459009066 Helix-turn-helix domain; Region: HTH_28; pfam13518 1072459009067 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 1072459009068 nickel binding site [ion binding]; other site 1072459009069 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 1072459009070 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 1072459009071 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 1072459009072 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1072459009073 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 1072459009074 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 1072459009075 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1072459009076 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1072459009077 NADH dehydrogenase; Region: NADHdh; cl00469 1072459009078 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 1072459009079 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1072459009080 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 1072459009081 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 1072459009082 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 1072459009083 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 1072459009084 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 1072459009085 hydrogenase assembly chaperone; Provisional; Region: PRK10409 1072459009086 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 1072459009087 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 1072459009088 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 1072459009089 dimerization interface [polypeptide binding]; other site 1072459009090 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 1072459009091 ATP binding site [chemical binding]; other site 1072459009092 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 1072459009093 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1072459009094 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1072459009095 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1072459009096 Walker A motif; other site 1072459009097 ATP binding site [chemical binding]; other site 1072459009098 Walker B motif; other site 1072459009099 arginine finger; other site 1072459009100 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1072459009101 molybdenum-pterin binding domain; Region: Mop; TIGR00638 1072459009102 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 1072459009103 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 1072459009104 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1072459009105 MutS domain I; Region: MutS_I; pfam01624 1072459009106 MutS domain II; Region: MutS_II; pfam05188 1072459009107 MutS domain III; Region: MutS_III; pfam05192 1072459009108 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1072459009109 Walker A/P-loop; other site 1072459009110 ATP binding site [chemical binding]; other site 1072459009111 Q-loop/lid; other site 1072459009112 ABC transporter signature motif; other site 1072459009113 Walker B; other site 1072459009114 D-loop; other site 1072459009115 H-loop/switch region; other site 1072459009116 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 1072459009117 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1072459009118 active site 1072459009119 metal binding site [ion binding]; metal-binding site 1072459009120 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 1072459009121 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 1072459009122 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 1072459009123 Flavoprotein; Region: Flavoprotein; pfam02441 1072459009124 MarR family; Region: MarR_2; cl17246 1072459009125 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1072459009126 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 1072459009127 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1072459009128 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1072459009129 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1072459009130 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1072459009131 DNA binding residues [nucleotide binding] 1072459009132 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1072459009133 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1072459009134 Peptidase family M23; Region: Peptidase_M23; pfam01551 1072459009135 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 1072459009136 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1072459009137 S-adenosylmethionine binding site [chemical binding]; other site 1072459009138 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 1072459009139 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 1072459009140 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 1072459009141 Permutation of conserved domain; other site 1072459009142 active site 1072459009143 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1072459009144 homotrimer interaction site [polypeptide binding]; other site 1072459009145 zinc binding site [ion binding]; other site 1072459009146 CDP-binding sites; other site 1072459009147 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1072459009148 substrate binding site; other site 1072459009149 dimer interface; other site 1072459009150 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 1072459009151 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1072459009152 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 1072459009153 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1072459009154 ligand-binding site [chemical binding]; other site 1072459009155 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 1072459009156 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1072459009157 CysD dimerization site [polypeptide binding]; other site 1072459009158 G1 box; other site 1072459009159 putative GEF interaction site [polypeptide binding]; other site 1072459009160 GTP/Mg2+ binding site [chemical binding]; other site 1072459009161 Switch I region; other site 1072459009162 G2 box; other site 1072459009163 G3 box; other site 1072459009164 Switch II region; other site 1072459009165 G4 box; other site 1072459009166 G5 box; other site 1072459009167 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1072459009168 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1072459009169 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1072459009170 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1072459009171 Active Sites [active] 1072459009172 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 1072459009173 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 1072459009174 metal binding site [ion binding]; metal-binding site 1072459009175 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1072459009176 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1072459009177 Active Sites [active] 1072459009178 sulfite reductase subunit beta; Provisional; Region: PRK13504 1072459009179 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1072459009180 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1072459009181 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 1072459009182 Flavodoxin; Region: Flavodoxin_1; pfam00258 1072459009183 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1072459009184 FAD binding pocket [chemical binding]; other site 1072459009185 FAD binding motif [chemical binding]; other site 1072459009186 catalytic residues [active] 1072459009187 NAD binding pocket [chemical binding]; other site 1072459009188 phosphate binding motif [ion binding]; other site 1072459009189 beta-alpha-beta structure motif; other site 1072459009190 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1072459009191 active site 1072459009192 putative oxidoreductase FixC; Provisional; Region: PRK10157 1072459009193 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 1072459009194 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 1072459009195 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1072459009196 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1072459009197 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1072459009198 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1072459009199 Ligand binding site [chemical binding]; other site 1072459009200 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1072459009201 benzoate transport; Region: 2A0115; TIGR00895 1072459009202 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459009203 putative substrate translocation pore; other site 1072459009204 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1072459009205 FAD binding domain; Region: FAD_binding_4; pfam01565 1072459009206 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 1072459009207 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1072459009208 NADP binding site [chemical binding]; other site 1072459009209 homodimer interface [polypeptide binding]; other site 1072459009210 active site 1072459009211 putative transposase OrfB; Reviewed; Region: PHA02517 1072459009212 HTH-like domain; Region: HTH_21; pfam13276 1072459009213 Integrase core domain; Region: rve; pfam00665 1072459009214 Integrase core domain; Region: rve_3; pfam13683 1072459009215 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1072459009216 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1072459009217 nucleotide binding site [chemical binding]; other site 1072459009218 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1072459009219 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1072459009220 putative substrate binding site [chemical binding]; other site 1072459009221 putative ATP binding site [chemical binding]; other site 1072459009222 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1072459009223 trimer interface; other site 1072459009224 sugar binding site [chemical binding]; other site 1072459009225 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1072459009226 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1072459009227 active site turn [active] 1072459009228 phosphorylation site [posttranslational modification] 1072459009229 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1072459009230 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 1072459009231 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1072459009232 substrate binding [chemical binding]; other site 1072459009233 active site 1072459009234 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1072459009235 D-fructose-responsive transcription factor; Region: fruct_sucro_rep; TIGR02417 1072459009236 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1072459009237 DNA binding site [nucleotide binding] 1072459009238 domain linker motif; other site 1072459009239 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 1072459009240 dimerization interface [polypeptide binding]; other site 1072459009241 ligand binding site [chemical binding]; other site 1072459009242 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 1072459009243 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 1072459009244 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 1072459009245 Repair protein; Region: Repair_PSII; pfam04536 1072459009246 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 1072459009247 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1072459009248 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1072459009249 enolase; Provisional; Region: eno; PRK00077 1072459009250 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1072459009251 dimer interface [polypeptide binding]; other site 1072459009252 metal binding site [ion binding]; metal-binding site 1072459009253 substrate binding pocket [chemical binding]; other site 1072459009254 CTP synthetase; Validated; Region: pyrG; PRK05380 1072459009255 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1072459009256 Catalytic site [active] 1072459009257 active site 1072459009258 UTP binding site [chemical binding]; other site 1072459009259 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1072459009260 active site 1072459009261 putative oxyanion hole; other site 1072459009262 catalytic triad [active] 1072459009263 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 1072459009264 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1072459009265 homodimer interface [polypeptide binding]; other site 1072459009266 metal binding site [ion binding]; metal-binding site 1072459009267 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1072459009268 homodimer interface [polypeptide binding]; other site 1072459009269 active site 1072459009270 putative chemical substrate binding site [chemical binding]; other site 1072459009271 metal binding site [ion binding]; metal-binding site 1072459009272 toxin MazF; Provisional; Region: PRK09907 1072459009273 antitoxin MazE; Provisional; Region: PRK09798 1072459009274 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 1072459009275 HD domain; Region: HD_4; pfam13328 1072459009276 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1072459009277 synthetase active site [active] 1072459009278 NTP binding site [chemical binding]; other site 1072459009279 metal binding site [ion binding]; metal-binding site 1072459009280 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1072459009281 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1072459009282 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 1072459009283 TRAM domain; Region: TRAM; pfam01938 1072459009284 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1072459009285 S-adenosylmethionine binding site [chemical binding]; other site 1072459009286 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 1072459009287 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 1072459009288 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1072459009289 dimerization interface [polypeptide binding]; other site 1072459009290 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1072459009291 dimer interface [polypeptide binding]; other site 1072459009292 phosphorylation site [posttranslational modification] 1072459009293 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1072459009294 ATP binding site [chemical binding]; other site 1072459009295 Mg2+ binding site [ion binding]; other site 1072459009296 G-X-G motif; other site 1072459009297 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 1072459009298 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1072459009299 active site 1072459009300 phosphorylation site [posttranslational modification] 1072459009301 intermolecular recognition site; other site 1072459009302 dimerization interface [polypeptide binding]; other site 1072459009303 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1072459009304 putative binding surface; other site 1072459009305 active site 1072459009306 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 1072459009307 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 1072459009308 active site 1072459009309 tetramer interface [polypeptide binding]; other site 1072459009310 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 1072459009311 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 1072459009312 active site 1072459009313 tetramer interface [polypeptide binding]; other site 1072459009314 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459009315 D-galactonate transporter; Region: 2A0114; TIGR00893 1072459009316 putative substrate translocation pore; other site 1072459009317 flavodoxin; Provisional; Region: PRK08105 1072459009318 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1072459009319 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 1072459009320 probable active site [active] 1072459009321 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 1072459009322 SecY interacting protein Syd; Provisional; Region: PRK04968 1072459009323 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 1072459009324 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 1072459009325 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 1072459009326 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1072459009327 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 1072459009328 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1072459009329 serine transporter; Region: stp; TIGR00814 1072459009330 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1072459009331 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1072459009332 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1072459009333 flap endonuclease-like protein; Provisional; Region: PRK09482 1072459009334 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1072459009335 active site 1072459009336 metal binding site 1 [ion binding]; metal-binding site 1072459009337 putative 5' ssDNA interaction site; other site 1072459009338 metal binding site 3; metal-binding site 1072459009339 metal binding site 2 [ion binding]; metal-binding site 1072459009340 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1072459009341 putative DNA binding site [nucleotide binding]; other site 1072459009342 putative metal binding site [ion binding]; other site 1072459009343 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 1072459009344 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 1072459009345 dimer interface [polypeptide binding]; other site 1072459009346 active site 1072459009347 metal binding site [ion binding]; metal-binding site 1072459009348 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1072459009349 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1072459009350 intersubunit interface [polypeptide binding]; other site 1072459009351 active site 1072459009352 Zn2+ binding site [ion binding]; other site 1072459009353 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1072459009354 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459009355 putative substrate translocation pore; other site 1072459009356 L-fucose isomerase; Provisional; Region: fucI; PRK10991 1072459009357 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 1072459009358 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1072459009359 trimer interface [polypeptide binding]; other site 1072459009360 substrate binding site [chemical binding]; other site 1072459009361 Mn binding site [ion binding]; other site 1072459009362 L-fuculokinase; Provisional; Region: PRK10331 1072459009363 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1072459009364 nucleotide binding site [chemical binding]; other site 1072459009365 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 1072459009366 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 1072459009367 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1072459009368 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1072459009369 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 1072459009370 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1072459009371 hypothetical protein; Provisional; Region: PRK10873 1072459009372 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1072459009373 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1072459009374 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1072459009375 dimerization interface [polypeptide binding]; other site 1072459009376 substrate binding pocket [chemical binding]; other site 1072459009377 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1072459009378 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1072459009379 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1072459009380 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1072459009381 catalytic residue [active] 1072459009382 CsdA-binding activator; Provisional; Region: PRK15019 1072459009383 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 1072459009384 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1072459009385 putative ATP binding site [chemical binding]; other site 1072459009386 putative substrate interface [chemical binding]; other site 1072459009387 murein transglycosylase A; Provisional; Region: mltA; PRK11162 1072459009388 MltA specific insert domain; Region: MltA; pfam03562 1072459009389 3D domain; Region: 3D; pfam06725 1072459009390 AMIN domain; Region: AMIN; pfam11741 1072459009391 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1072459009392 active site 1072459009393 metal binding site [ion binding]; metal-binding site 1072459009394 N-acetylglutamate synthase; Validated; Region: PRK05279 1072459009395 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 1072459009396 putative feedback inhibition sensing region; other site 1072459009397 putative nucleotide binding site [chemical binding]; other site 1072459009398 putative substrate binding site [chemical binding]; other site 1072459009399 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1072459009400 Coenzyme A binding pocket [chemical binding]; other site 1072459009401 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 1072459009402 AAA domain; Region: AAA_30; pfam13604 1072459009403 Family description; Region: UvrD_C_2; pfam13538 1072459009404 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 1072459009405 protease3; Provisional; Region: PRK15101 1072459009406 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1072459009407 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1072459009408 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1072459009409 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1072459009410 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 1072459009411 hypothetical protein; Provisional; Region: PRK10332 1072459009412 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 1072459009413 hypothetical protein; Provisional; Region: PRK11521 1072459009414 hypothetical protein; Provisional; Region: PRK10557 1072459009415 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1072459009416 hypothetical protein; Provisional; Region: PRK10506 1072459009417 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1072459009418 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1072459009419 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1072459009420 dimerization interface [polypeptide binding]; other site 1072459009421 active site 1072459009422 prolipoprotein diacylglyceryl transferase; Region: lgt; TIGR00544 1072459009423 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 1072459009424 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1072459009425 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1072459009426 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1072459009427 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1072459009428 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 1072459009429 putative active site [active] 1072459009430 Ap4A binding site [chemical binding]; other site 1072459009431 nudix motif; other site 1072459009432 putative metal binding site [ion binding]; other site 1072459009433 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 1072459009434 putative DNA-binding cleft [nucleotide binding]; other site 1072459009435 putative DNA clevage site; other site 1072459009436 molecular lever; other site 1072459009437 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1072459009438 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1072459009439 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1072459009440 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1072459009441 active site 1072459009442 catalytic tetrad [active] 1072459009443 lysophospholipid transporter LplT; Provisional; Region: PRK11195 1072459009444 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459009445 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 1072459009446 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1072459009447 putative acyl-acceptor binding pocket; other site 1072459009448 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 1072459009449 acyl-activating enzyme (AAE) consensus motif; other site 1072459009450 putative AMP binding site [chemical binding]; other site 1072459009451 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 1072459009452 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1072459009453 DNA binding site [nucleotide binding] 1072459009454 domain linker motif; other site 1072459009455 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1072459009456 dimerization interface (closed form) [polypeptide binding]; other site 1072459009457 ligand binding site [chemical binding]; other site 1072459009458 diaminopimelate decarboxylase; Provisional; Region: PRK11165 1072459009459 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1072459009460 active site 1072459009461 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1072459009462 substrate binding site [chemical binding]; other site 1072459009463 catalytic residues [active] 1072459009464 dimer interface [polypeptide binding]; other site 1072459009465 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 1072459009466 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1072459009467 The C-terminal substrate binding domain of LysR, transcriptional regulator for lysine biosynthesis, contains the type 2 periplasmic binding fold; Region: PBP2_LysR; cd08456 1072459009468 putative dimerization interface [polypeptide binding]; other site 1072459009469 putative racemase; Provisional; Region: PRK10200 1072459009470 aspartate racemase; Region: asp_race; TIGR00035 1072459009471 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1072459009472 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459009473 putative substrate translocation pore; other site 1072459009474 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459009475 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 1072459009476 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1072459009477 NADP binding site [chemical binding]; other site 1072459009478 homodimer interface [polypeptide binding]; other site 1072459009479 active site 1072459009480 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 1072459009481 putative acyltransferase; Provisional; Region: PRK05790 1072459009482 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1072459009483 dimer interface [polypeptide binding]; other site 1072459009484 active site 1072459009485 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1072459009486 serine transporter; Region: stp; TIGR00814 1072459009487 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 1072459009488 DNA binding residues [nucleotide binding] 1072459009489 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 1072459009490 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 1072459009491 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 1072459009492 Tetratricopeptide repeat; Region: TPR_3; pfam07720 1072459009493 Tetratricopeptide repeat; Region: TPR_3; pfam07720 1072459009494 transcriptional regulator; Provisional; Region: PRK11906 1072459009495 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1072459009496 DNA binding site [nucleotide binding] 1072459009497 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1072459009498 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1072459009499 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1072459009500 catalytic residue [active] 1072459009501 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1072459009502 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1072459009503 DNA binding residues [nucleotide binding] 1072459009504 dimerization interface [polypeptide binding]; other site 1072459009505 invasion protein OrgB; Provisional; Region: PRK15322 1072459009506 Type III secretory pathway, lipoprotein EscJ [Intracellular trafficking and secretion]; Region: EscJ; COG4669 1072459009507 type III secretion system needle complex protein PrgJ; Provisional; Region: PRK15325 1072459009508 Type III secretion needle MxiH like; Region: MxiH; cl09641 1072459009509 type III secretion system needle complex protein PrgH; Provisional; Region: PRK15327; cl12363 1072459009510 Type III secretion system protein PrgH-EprH (PrgH); Region: PrgH; pfam09480 1072459009511 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 1072459009512 type III secretion protein SpaR/YscT/HrcT; Region: fliR_like_III; TIGR01401 1072459009513 type III secretion system protein SpaQ; Provisional; Region: PRK15333 1072459009514 type III secretion system protein SpaP; Provisional; Region: spaP; PRK12796 1072459009515 Surface presentation of antigens protein; Region: SPAN; pfam02510 1072459009516 Salmonella surface presentation of antigen gene type M protein; Region: SPAM; cl03442 1072459009517 ATP synthase SpaL; Validated; Region: PRK08149 1072459009518 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1072459009519 Walker A motif; other site 1072459009520 ATP binding site [chemical binding]; other site 1072459009521 Walker B motif; other site 1072459009522 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 1072459009523 type III secretion system protein InvA; Provisional; Region: PRK15337 1072459009524 type III secretion system regulator InvE; Provisional; Region: PRK15338 1072459009525 HrpJ-like domain; Region: HrpJ; pfam07201 1072459009526 type III secretion system outer membrane pore InvG; Provisional; Region: PRK15339 1072459009527 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1072459009528 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1072459009529 transcriptional regulator InvF; Provisional; Region: PRK15340 1072459009530 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1072459009531 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1072459009532 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1072459009533 Peptidase family M23; Region: Peptidase_M23; pfam01551 1072459009534 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 1072459009535 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 1072459009536 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1072459009537 xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971 1072459009538 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 1072459009539 xanthine dehydrogenase subunit XdhC; Provisional; Region: PRK09908 1072459009540 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1072459009541 catalytic loop [active] 1072459009542 iron binding site [ion binding]; other site 1072459009543 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1072459009544 GAF domain; Region: GAF; cl17456 1072459009545 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 1072459009546 PAS domain; Region: PAS; smart00091 1072459009547 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1072459009548 Walker A motif; other site 1072459009549 ATP binding site [chemical binding]; other site 1072459009550 Walker B motif; other site 1072459009551 arginine finger; other site 1072459009552 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1072459009553 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 1072459009554 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1072459009555 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1072459009556 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1072459009557 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 1072459009558 catalytic residue [active] 1072459009559 peptidase; Reviewed; Region: PRK13004 1072459009560 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 1072459009561 putative metal binding site [ion binding]; other site 1072459009562 putative dimer interface [polypeptide binding]; other site 1072459009563 D-hydantoinase; Region: D-hydantoinase; TIGR02033 1072459009564 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 1072459009565 tetramer interface [polypeptide binding]; other site 1072459009566 active site 1072459009567 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1072459009568 carbamate kinase; Reviewed; Region: PRK12686 1072459009569 putative substrate binding site [chemical binding]; other site 1072459009570 homodimer interface [polypeptide binding]; other site 1072459009571 nucleotide binding site [chemical binding]; other site 1072459009572 nucleotide binding site [chemical binding]; other site 1072459009573 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1072459009574 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1072459009575 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1072459009576 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 1072459009577 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1072459009578 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 1072459009579 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1072459009580 Ligand binding site; other site 1072459009581 metal-binding site 1072459009582 putative selenate reductase subunit YgfK; Provisional; Region: PRK09853 1072459009583 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1072459009584 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1072459009585 putative selenium metabolism protein SsnA; Region: Se_ssnA; TIGR03314 1072459009586 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1072459009587 active site 1072459009588 putative substrate binding pocket [chemical binding]; other site 1072459009589 probable selenate reductase, FAD-binding subunit; Region: Se_sel_red_FAD; TIGR03312 1072459009590 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 1072459009591 putative hypoxanthine oxidase; Provisional; Region: PRK09800 1072459009592 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1072459009593 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 1072459009594 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1072459009595 uracil-xanthine permease; Region: ncs2; TIGR00801 1072459009596 guanine deaminase; Provisional; Region: PRK09228 1072459009597 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 1072459009598 active site 1072459009599 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1072459009600 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 1072459009601 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12809 1072459009602 4Fe-4S binding domain; Region: Fer4; pfam00037 1072459009603 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1072459009604 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1072459009605 xanthine permease; Region: pbuX; TIGR03173 1072459009606 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 1072459009607 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 1072459009608 active site 1072459009609 metal binding site [ion binding]; metal-binding site 1072459009610 nudix motif; other site 1072459009611 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1072459009612 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1072459009613 dimer interface [polypeptide binding]; other site 1072459009614 putative anticodon binding site; other site 1072459009615 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1072459009616 motif 1; other site 1072459009617 active site 1072459009618 motif 2; other site 1072459009619 motif 3; other site 1072459009620 peptide chain release factor 2; Provisional; Region: PRK08787 1072459009621 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1072459009622 RF-1 domain; Region: RF-1; pfam00472 1072459009623 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 1072459009624 DHH family; Region: DHH; pfam01368 1072459009625 DHHA1 domain; Region: DHHA1; pfam02272 1072459009626 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 1072459009627 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1072459009628 dimerization domain [polypeptide binding]; other site 1072459009629 dimer interface [polypeptide binding]; other site 1072459009630 catalytic residues [active] 1072459009631 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1072459009632 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1072459009633 active site 1072459009634 Int/Topo IB signature motif; other site 1072459009635 flavodoxin FldB; Provisional; Region: PRK12359 1072459009636 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 1072459009637 hypothetical protein; Provisional; Region: PRK10878 1072459009638 putative global regulator; Reviewed; Region: PRK09559 1072459009639 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1072459009640 hemolysin; Provisional; Region: PRK15087 1072459009641 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1072459009642 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 1072459009643 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 1072459009644 beta-galactosidase; Region: BGL; TIGR03356 1072459009645 glycine dehydrogenase; Provisional; Region: PRK05367 1072459009646 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1072459009647 tetramer interface [polypeptide binding]; other site 1072459009648 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1072459009649 catalytic residue [active] 1072459009650 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1072459009651 tetramer interface [polypeptide binding]; other site 1072459009652 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1072459009653 catalytic residue [active] 1072459009654 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1072459009655 lipoyl attachment site [posttranslational modification]; other site 1072459009656 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1072459009657 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1072459009658 oxidoreductase; Provisional; Region: PRK08013 1072459009659 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 1072459009660 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 1072459009661 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 1072459009662 proline aminopeptidase P II; Provisional; Region: PRK10879 1072459009663 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 1072459009664 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1072459009665 active site 1072459009666 hypothetical protein; Reviewed; Region: PRK01736 1072459009667 Z-ring-associated protein; Provisional; Region: PRK10972 1072459009668 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1072459009669 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 1072459009670 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1072459009671 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 1072459009672 ligand binding site [chemical binding]; other site 1072459009673 NAD binding site [chemical binding]; other site 1072459009674 tetramer interface [polypeptide binding]; other site 1072459009675 catalytic site [active] 1072459009676 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1072459009677 L-serine binding site [chemical binding]; other site 1072459009678 ACT domain interface; other site 1072459009679 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1072459009680 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1072459009681 active site 1072459009682 dimer interface [polypeptide binding]; other site 1072459009683 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1072459009684 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1072459009685 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 1072459009686 putative dimerization interface [polypeptide binding]; other site 1072459009687 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 1072459009688 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 1072459009689 active site 1072459009690 substrate binding site [chemical binding]; other site 1072459009691 coenzyme B12 binding site [chemical binding]; other site 1072459009692 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1072459009693 B12 binding site [chemical binding]; other site 1072459009694 cobalt ligand [ion binding]; other site 1072459009695 membrane ATPase/protein kinase; Provisional; Region: PRK09435 1072459009696 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1072459009697 Walker A; other site 1072459009698 methylmalonyl-CoA decarboxylase; Provisional; Region: PRK11423 1072459009699 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1072459009700 substrate binding site [chemical binding]; other site 1072459009701 oxyanion hole (OAH) forming residues; other site 1072459009702 trimer interface [polypeptide binding]; other site 1072459009703 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1072459009704 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 1072459009705 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1072459009706 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1072459009707 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1072459009708 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1072459009709 dimerization interface [polypeptide binding]; other site 1072459009710 Uncharacterized conserved protein [Function unknown]; Region: COG2968 1072459009711 oxidative stress defense protein; Provisional; Region: PRK11087 1072459009712 arginine exporter protein; Provisional; Region: PRK09304 1072459009713 mechanosensitive channel MscS; Provisional; Region: PRK10334 1072459009714 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1072459009715 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1072459009716 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 1072459009717 active site 1072459009718 intersubunit interface [polypeptide binding]; other site 1072459009719 zinc binding site [ion binding]; other site 1072459009720 Na+ binding site [ion binding]; other site 1072459009721 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1072459009722 Phosphoglycerate kinase; Region: PGK; pfam00162 1072459009723 substrate binding site [chemical binding]; other site 1072459009724 hinge regions; other site 1072459009725 ADP binding site [chemical binding]; other site 1072459009726 catalytic site [active] 1072459009727 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 1072459009728 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1072459009729 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1072459009730 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 1072459009731 trimer interface [polypeptide binding]; other site 1072459009732 putative Zn binding site [ion binding]; other site 1072459009733 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1072459009734 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1072459009735 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1072459009736 Walker A/P-loop; other site 1072459009737 ATP binding site [chemical binding]; other site 1072459009738 Q-loop/lid; other site 1072459009739 ABC transporter signature motif; other site 1072459009740 Walker B; other site 1072459009741 D-loop; other site 1072459009742 H-loop/switch region; other site 1072459009743 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1072459009744 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1072459009745 Walker A/P-loop; other site 1072459009746 ATP binding site [chemical binding]; other site 1072459009747 Q-loop/lid; other site 1072459009748 ABC transporter signature motif; other site 1072459009749 Walker B; other site 1072459009750 D-loop; other site 1072459009751 H-loop/switch region; other site 1072459009752 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 1072459009753 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1072459009754 active site 1072459009755 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 1072459009756 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10022 1072459009757 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1072459009758 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1072459009759 putative active site [active] 1072459009760 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 1072459009761 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1072459009762 putative NAD(P) binding site [chemical binding]; other site 1072459009763 catalytic Zn binding site [ion binding]; other site 1072459009764 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 1072459009765 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1072459009766 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1072459009767 active site 1072459009768 P-loop; other site 1072459009769 phosphorylation site [posttranslational modification] 1072459009770 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1072459009771 active site 1072459009772 phosphorylation site [posttranslational modification] 1072459009773 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1072459009774 SPFH domain / Band 7 family; Region: Band_7; pfam01145 1072459009775 transketolase; Reviewed; Region: PRK12753 1072459009776 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1072459009777 TPP-binding site [chemical binding]; other site 1072459009778 dimer interface [polypeptide binding]; other site 1072459009779 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1072459009780 PYR/PP interface [polypeptide binding]; other site 1072459009781 dimer interface [polypeptide binding]; other site 1072459009782 TPP binding site [chemical binding]; other site 1072459009783 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1072459009784 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1072459009785 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 1072459009786 agmatinase; Region: agmatinase; TIGR01230 1072459009787 oligomer interface [polypeptide binding]; other site 1072459009788 putative active site [active] 1072459009789 Mn binding site [ion binding]; other site 1072459009790 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 1072459009791 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 1072459009792 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 1072459009793 dimer interface [polypeptide binding]; other site 1072459009794 active site 1072459009795 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1072459009796 catalytic residues [active] 1072459009797 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1072459009798 Virulence promoting factor; Region: YqgB; pfam11036 1072459009799 Protein of unknown function (DUF2684); Region: DUF2684; pfam10885 1072459009800 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1072459009801 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1072459009802 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1072459009803 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1072459009804 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1072459009805 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459009806 putative substrate translocation pore; other site 1072459009807 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459009808 hypothetical protein; Provisional; Region: PRK04860 1072459009809 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 1072459009810 DNA-specific endonuclease I; Provisional; Region: PRK15137 1072459009811 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 1072459009812 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1072459009813 RNA methyltransferase, RsmE family; Region: TIGR00046 1072459009814 glutathione synthetase; Provisional; Region: PRK05246 1072459009815 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 1072459009816 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 1072459009817 hypothetical protein; Validated; Region: PRK00228 1072459009818 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1072459009819 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1072459009820 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 1072459009821 Walker A motif; other site 1072459009822 ATP binding site [chemical binding]; other site 1072459009823 Walker B motif; other site 1072459009824 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 1072459009825 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1072459009826 catalytic residue [active] 1072459009827 YGGT family; Region: YGGT; pfam02325 1072459009828 YGGT family; Region: YGGT; pfam02325 1072459009829 hypothetical protein; Validated; Region: PRK05090 1072459009830 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1072459009831 active site 1072459009832 dimerization interface [polypeptide binding]; other site 1072459009833 HemN family oxidoreductase; Provisional; Region: PRK05660 1072459009834 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1072459009835 FeS/SAM binding site; other site 1072459009836 HemN C-terminal domain; Region: HemN_C; pfam06969 1072459009837 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1072459009838 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 1072459009839 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1072459009840 putative transposase OrfB; Reviewed; Region: PHA02517 1072459009841 HTH-like domain; Region: HTH_21; pfam13276 1072459009842 Integrase core domain; Region: rve; pfam00665 1072459009843 Integrase core domain; Region: rve_3; pfam13683 1072459009844 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 1072459009845 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 1072459009846 homodimer interface [polypeptide binding]; other site 1072459009847 active site 1072459009848 hypothetical protein; Provisional; Region: PRK10626 1072459009849 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 1072459009850 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 1072459009851 hypothetical protein; Provisional; Region: PRK11702 1072459009852 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 1072459009853 adenine DNA glycosylase; Provisional; Region: PRK10880 1072459009854 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1072459009855 minor groove reading motif; other site 1072459009856 helix-hairpin-helix signature motif; other site 1072459009857 substrate binding pocket [chemical binding]; other site 1072459009858 active site 1072459009859 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1072459009860 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1072459009861 DNA binding and oxoG recognition site [nucleotide binding] 1072459009862 oxidative damage protection protein; Provisional; Region: PRK05408 1072459009863 murein transglycosylase C; Provisional; Region: mltC; PRK11671 1072459009864 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 1072459009865 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1072459009866 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1072459009867 catalytic residue [active] 1072459009868 nucleoside transporter; Region: 2A0110; TIGR00889 1072459009869 ornithine decarboxylase; Provisional; Region: PRK13578 1072459009870 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1072459009871 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1072459009872 homodimer interface [polypeptide binding]; other site 1072459009873 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1072459009874 catalytic residue [active] 1072459009875 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1072459009876 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 1072459009877 integrase; Provisional; Region: PRK09692 1072459009878 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1072459009879 active site 1072459009880 Int/Topo IB signature motif; other site 1072459009881 DNA primase; Validated; Region: dnaG; PRK05667 1072459009882 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 1072459009883 MarR family; Region: MarR_2; cl17246 1072459009884 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1072459009885 Integrase core domain; Region: rve_3; cl15866 1072459009886 putative transposase OrfB; Reviewed; Region: PHA02517 1072459009887 Transposase; Region: HTH_Tnp_1; cl17663 1072459009888 Fimbrial protein; Region: Fimbrial; pfam00419 1072459009889 Fimbrial protein; Region: Fimbrial; pfam00419 1072459009890 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 1072459009891 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1072459009892 FaeA-like protein; Region: FaeA; pfam04703 1072459009893 HTH-like domain; Region: HTH_21; pfam13276 1072459009894 Integrase core domain; Region: rve; pfam00665 1072459009895 Integrase core domain; Region: rve_3; pfam13683 1072459009896 CE10_3433; putative transposase,fragment 1072459009897 CE10_3434; putative transposase,fragment 1072459009898 transposase/IS protein; Provisional; Region: PRK09183 1072459009899 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1072459009900 Walker A motif; other site 1072459009901 ATP binding site [chemical binding]; other site 1072459009902 Walker B motif; other site 1072459009903 arginine finger; other site 1072459009904 CE10_3436; putative transposase B, IS3411, fragment 1072459009905 CE10_3439; putative transposase, fragment 1072459009906 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1072459009907 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1072459009908 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1072459009909 Protein of unknown function, DUF417; Region: DUF417; pfam04224 1072459009910 Transposase; Region: HTH_Tnp_1; cl17663 1072459009911 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1072459009912 IS2 transposase TnpB; Reviewed; Region: PRK09409 1072459009913 HTH-like domain; Region: HTH_21; pfam13276 1072459009914 Integrase core domain; Region: rve; pfam00665 1072459009915 Integrase core domain; Region: rve_3; pfam13683 1072459009916 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459009917 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1072459009918 putative substrate translocation pore; other site 1072459009919 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1072459009920 IucA / IucC family; Region: IucA_IucC; pfam04183 1072459009921 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1072459009922 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1072459009923 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1072459009924 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1072459009925 IucA / IucC family; Region: IucA_IucC; pfam04183 1072459009926 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1072459009927 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 1072459009928 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1072459009929 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1072459009930 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1072459009931 N-terminal plug; other site 1072459009932 ligand-binding site [chemical binding]; other site 1072459009933 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 1072459009934 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 1072459009935 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 1072459009936 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1072459009937 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1072459009938 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1072459009939 Transposase; Region: HTH_Tnp_1; pfam01527 1072459009940 putative transposase OrfB; Reviewed; Region: PHA02517 1072459009941 HTH-like domain; Region: HTH_21; pfam13276 1072459009942 Integrase core domain; Region: rve; pfam00665 1072459009943 Integrase core domain; Region: rve_3; pfam13683 1072459009944 Integrase core domain; Region: rve; pfam00665 1072459009945 Integrase core domain; Region: rve_2; pfam13333 1072459009946 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1072459009947 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1072459009948 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1072459009949 Transposase; Region: HTH_Tnp_1; cl17663 1072459009950 HTH-like domain; Region: HTH_21; pfam13276 1072459009951 Integrase core domain; Region: rve; pfam00665 1072459009952 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1072459009953 Integrase core domain; Region: rve_3; pfam13683 1072459009954 bifunctional enterobactin receptor/adhesin protein; Provisional; Region: PRK13486 1072459009955 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1072459009956 N-terminal plug; other site 1072459009957 ligand-binding site [chemical binding]; other site 1072459009958 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1072459009959 Transposase; Region: HTH_Tnp_1; pfam01527 1072459009960 putative transposase OrfB; Reviewed; Region: PHA02517 1072459009961 Integrase core domain; Region: rve; pfam00665 1072459009962 Integrase core domain; Region: rve_3; pfam13683 1072459009963 KpsF/GutQ family protein; Region: kpsF; TIGR00393 1072459009964 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1072459009965 putative active site [active] 1072459009966 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1072459009967 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 1072459009968 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 1072459009969 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1072459009970 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1072459009971 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1072459009972 Ligand binding site; other site 1072459009973 oligomer interface; other site 1072459009974 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 1072459009975 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 1072459009976 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 1072459009977 Alpha-2,8-polysialyltransferase (POLYST); Region: A-2_8-polyST; pfam07388 1072459009978 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 1072459009979 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1072459009980 active site 1072459009981 homodimer interface [polypeptide binding]; other site 1072459009982 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 1072459009983 NeuB family; Region: NeuB; pfam03102 1072459009984 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 1072459009985 NeuB binding interface [polypeptide binding]; other site 1072459009986 putative substrate binding site [chemical binding]; other site 1072459009987 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1072459009988 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1072459009989 Walker A/P-loop; other site 1072459009990 ATP binding site [chemical binding]; other site 1072459009991 Q-loop/lid; other site 1072459009992 ABC transporter signature motif; other site 1072459009993 Walker B; other site 1072459009994 D-loop; other site 1072459009995 H-loop/switch region; other site 1072459009996 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1072459009997 putative general secretion pathway protein YghD; Provisional; Region: PRK09731 1072459009998 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 1072459009999 GspL-like protein; Provisional; Region: PRK09662 1072459010000 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 1072459010001 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1072459010002 type II secretion system protein J; Region: gspJ; TIGR01711 1072459010003 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 1072459010004 type II secretion system protein I; Region: gspI; TIGR01707 1072459010005 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 1072459010006 Prokaryotic N-terminal methylation motif; Region: N_methyl; pfam07963 1072459010007 Type II transport protein GspH; Region: GspH; pfam12019 1072459010008 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1072459010009 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 1072459010010 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1072459010011 type II secretion system protein F; Region: GspF; TIGR02120 1072459010012 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1072459010013 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1072459010014 type II secretion system protein E; Region: type_II_gspE; TIGR02533 1072459010015 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1072459010016 Walker A motif; other site 1072459010017 ATP binding site [chemical binding]; other site 1072459010018 Walker B motif; other site 1072459010019 type II secretion system protein D; Region: type_II_gspD; TIGR02517 1072459010020 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1072459010021 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1072459010022 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1072459010023 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1072459010024 putative type II secretion protein GspC; Provisional; Region: PRK09681 1072459010025 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 1072459010026 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1072459010027 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1072459010028 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1072459010029 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1072459010030 Domain of unknown function (DUF4092); Region: DUF4092; pfam13322 1072459010031 Peptidase M60-like family; Region: M60-like; pfam13402 1072459010032 glycolate transporter; Provisional; Region: PRK09695 1072459010033 L-lactate permease; Region: Lactate_perm; cl00701 1072459010034 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 1072459010035 active site 1072459010036 hypothetical protein; Provisional; Region: PRK09732 1072459010037 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 1072459010038 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1072459010039 Cysteine-rich domain; Region: CCG; pfam02754 1072459010040 Cysteine-rich domain; Region: CCG; pfam02754 1072459010041 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 1072459010042 FAD binding domain; Region: FAD_binding_4; pfam01565 1072459010043 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 1072459010044 FAD binding domain; Region: FAD_binding_4; pfam01565 1072459010045 DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990 1072459010046 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1072459010047 DNA-binding site [nucleotide binding]; DNA binding site 1072459010048 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1072459010049 acyl-CoA synthetase; Validated; Region: PRK09192 1072459010050 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1072459010051 acyl-activating enzyme (AAE) consensus motif; other site 1072459010052 active site 1072459010053 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1072459010054 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1072459010055 NAD(P) binding site [chemical binding]; other site 1072459010056 active site 1072459010057 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1072459010058 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1072459010059 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1072459010060 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1072459010061 catalytic residue [active] 1072459010062 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 1072459010063 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1072459010064 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1072459010065 Predicted permeases [General function prediction only]; Region: COG0795 1072459010066 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; pfam09695 1072459010067 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1072459010068 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1072459010069 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 1072459010070 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1072459010071 active site 1072459010072 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1072459010073 TMP-binding site; other site 1072459010074 ATP-binding site [chemical binding]; other site 1072459010075 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 1072459010076 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1072459010077 TMP-binding site; other site 1072459010078 ATP-binding site [chemical binding]; other site 1072459010079 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1072459010080 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1072459010081 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 1072459010082 CHAP domain; Region: CHAP; pfam05257 1072459010083 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1072459010084 putative S-transferase; Provisional; Region: PRK11752 1072459010085 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1072459010086 C-terminal domain interface [polypeptide binding]; other site 1072459010087 GSH binding site (G-site) [chemical binding]; other site 1072459010088 dimer interface [polypeptide binding]; other site 1072459010089 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 1072459010090 dimer interface [polypeptide binding]; other site 1072459010091 N-terminal domain interface [polypeptide binding]; other site 1072459010092 active site 1072459010093 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 1072459010094 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 1072459010095 hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380 1072459010096 hydrogenase 2-specific chaperone; Provisional; Region: PRK10465 1072459010097 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 1072459010098 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 1072459010099 putative substrate-binding site; other site 1072459010100 nickel binding site [ion binding]; other site 1072459010101 hydrogenase 2 large subunit; Provisional; Region: PRK10467 1072459010102 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 1072459010103 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 1072459010104 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 1072459010105 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 1072459010106 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1072459010107 hydrogenase 2 small subunit; Provisional; Region: PRK10468 1072459010108 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 1072459010109 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 1072459010110 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 1072459010111 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1072459010112 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1072459010113 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1072459010114 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1072459010115 active site 1072459010116 catalytic tetrad [active] 1072459010117 hypothetical protein; Provisional; Region: PRK05208 1072459010118 oxidoreductase; Provisional; Region: PRK07985 1072459010119 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1072459010120 NAD binding site [chemical binding]; other site 1072459010121 metal binding site [ion binding]; metal-binding site 1072459010122 active site 1072459010123 biopolymer transport protein ExbD; Provisional; Region: PRK11267 1072459010124 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1072459010125 biopolymer transport protein ExbB; Provisional; Region: PRK10414 1072459010126 cystathionine beta-lyase; Provisional; Region: PRK08114 1072459010127 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1072459010128 homodimer interface [polypeptide binding]; other site 1072459010129 substrate-cofactor binding pocket; other site 1072459010130 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1072459010131 catalytic residue [active] 1072459010132 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1072459010133 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1072459010134 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1072459010135 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1072459010136 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1072459010137 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1072459010138 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1072459010139 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1072459010140 dimer interface [polypeptide binding]; other site 1072459010141 active site 1072459010142 metal binding site [ion binding]; metal-binding site 1072459010143 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1072459010144 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1072459010145 active site 1072459010146 catalytic tetrad [active] 1072459010147 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 1072459010148 putative outer membrane lipoprotein; Provisional; Region: PRK09973 1072459010149 hypothetical protein; Provisional; Region: PRK01254 1072459010150 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 1072459010151 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 1072459010152 FtsI repressor; Provisional; Region: PRK10883 1072459010153 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1072459010154 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1072459010155 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 1072459010156 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1072459010157 putative acyl-acceptor binding pocket; other site 1072459010158 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 1072459010159 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1072459010160 CAP-like domain; other site 1072459010161 active site 1072459010162 primary dimer interface [polypeptide binding]; other site 1072459010163 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1072459010164 putative ABC transporter periplasmic-binding protein; Provisional; Region: PRK09755 1072459010165 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1072459010166 peptide binding site [polypeptide binding]; other site 1072459010167 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 1072459010168 toxin interface [polypeptide binding]; other site 1072459010169 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 1072459010170 Zn binding site [ion binding]; other site 1072459010171 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1072459010172 non-specific DNA binding site [nucleotide binding]; other site 1072459010173 salt bridge; other site 1072459010174 sequence-specific DNA binding site [nucleotide binding]; other site 1072459010175 Motility quorum-sensing regulator (MqsR); Region: MqsR; cd12869 1072459010176 peptide binding site [polypeptide binding]; other site 1072459010177 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 1072459010178 TIGR00156 family protein; Region: TIGR00156 1072459010179 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 1072459010180 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1072459010181 active site 1072459010182 phosphorylation site [posttranslational modification] 1072459010183 intermolecular recognition site; other site 1072459010184 dimerization interface [polypeptide binding]; other site 1072459010185 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1072459010186 DNA binding site [nucleotide binding] 1072459010187 sensor protein QseC; Provisional; Region: PRK10337 1072459010188 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1072459010189 dimer interface [polypeptide binding]; other site 1072459010190 phosphorylation site [posttranslational modification] 1072459010191 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1072459010192 ATP binding site [chemical binding]; other site 1072459010193 Mg2+ binding site [ion binding]; other site 1072459010194 G-X-G motif; other site 1072459010195 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1072459010196 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1072459010197 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 1072459010198 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1072459010199 ATP binding site [chemical binding]; other site 1072459010200 Mg2+ binding site [ion binding]; other site 1072459010201 G-X-G motif; other site 1072459010202 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1072459010203 anchoring element; other site 1072459010204 dimer interface [polypeptide binding]; other site 1072459010205 ATP binding site [chemical binding]; other site 1072459010206 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1072459010207 active site 1072459010208 metal binding site [ion binding]; metal-binding site 1072459010209 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1072459010210 esterase YqiA; Provisional; Region: PRK11071 1072459010211 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1072459010212 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1072459010213 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1072459010214 active site 1072459010215 metal binding site [ion binding]; metal-binding site 1072459010216 hexamer interface [polypeptide binding]; other site 1072459010217 putative dehydrogenase; Provisional; Region: PRK11039 1072459010218 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 1072459010219 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1072459010220 dimer interface [polypeptide binding]; other site 1072459010221 ADP-ribose binding site [chemical binding]; other site 1072459010222 active site 1072459010223 nudix motif; other site 1072459010224 metal binding site [ion binding]; metal-binding site 1072459010225 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 1072459010226 hypothetical protein; Provisional; Region: PRK11653 1072459010227 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1072459010228 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1072459010229 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1072459010230 putative active site [active] 1072459010231 metal binding site [ion binding]; metal-binding site 1072459010232 zinc transporter ZupT; Provisional; Region: PRK04201 1072459010233 ZIP Zinc transporter; Region: Zip; pfam02535 1072459010234 Protein of unknown function (DUF4051); Region: DUF4051; pfam13260 1072459010235 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 1072459010236 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 1072459010237 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 1072459010238 putative fimbrial protein; Provisional; Region: PRK09733 1072459010239 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1072459010240 PapC N-terminal domain; Region: PapC_N; pfam13954 1072459010241 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1072459010242 PapC C-terminal domain; Region: PapC_C; pfam13953 1072459010243 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1072459010244 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1072459010245 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1072459010246 Fimbrial protein; Region: Fimbrial; pfam00419 1072459010247 glycogen synthesis protein GlgS; Provisional; Region: PRK02922 1072459010248 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 1072459010249 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 1072459010250 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 1072459010251 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 1072459010252 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 1072459010253 putative ribose interaction site [chemical binding]; other site 1072459010254 putative ADP binding site [chemical binding]; other site 1072459010255 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 1072459010256 active site 1072459010257 nucleotide binding site [chemical binding]; other site 1072459010258 HIGH motif; other site 1072459010259 KMSKS motif; other site 1072459010260 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 1072459010261 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1072459010262 metal binding triad; other site 1072459010263 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1072459010264 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1072459010265 metal binding triad; other site 1072459010266 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1072459010267 Uncharacterized conserved protein [Function unknown]; Region: COG3025 1072459010268 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 1072459010269 putative active site [active] 1072459010270 putative metal binding residues [ion binding]; other site 1072459010271 signature motif; other site 1072459010272 putative triphosphate binding site [ion binding]; other site 1072459010273 CHAD domain; Region: CHAD; pfam05235 1072459010274 SH3 domain-containing protein; Provisional; Region: PRK10884 1072459010275 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1072459010276 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 1072459010277 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1072459010278 active site 1072459010279 NTP binding site [chemical binding]; other site 1072459010280 metal binding triad [ion binding]; metal-binding site 1072459010281 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1072459010282 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1072459010283 Zn2+ binding site [ion binding]; other site 1072459010284 Mg2+ binding site [ion binding]; other site 1072459010285 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1072459010286 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1072459010287 homooctamer interface [polypeptide binding]; other site 1072459010288 active site 1072459010289 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1072459010290 transcriptional activator TtdR; Provisional; Region: PRK09801 1072459010291 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1072459010292 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 1072459010293 putative effector binding pocket; other site 1072459010294 putative dimerization interface [polypeptide binding]; other site 1072459010295 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 1072459010296 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 1072459010297 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1072459010298 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1072459010299 transmembrane helices; other site 1072459010300 UGMP family protein; Validated; Region: PRK09604 1072459010301 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1072459010302 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1072459010303 DNA primase; Validated; Region: dnaG; PRK05667 1072459010304 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1072459010305 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1072459010306 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1072459010307 active site 1072459010308 metal binding site [ion binding]; metal-binding site 1072459010309 interdomain interaction site; other site 1072459010310 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1072459010311 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 1072459010312 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 1072459010313 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1072459010314 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1072459010315 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 1072459010316 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1072459010317 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1072459010318 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1072459010319 DNA binding residues [nucleotide binding] 1072459010320 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 1072459010321 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1072459010322 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1072459010323 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 1072459010324 active site 1072459010325 SUMO-1 interface [polypeptide binding]; other site 1072459010326 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1072459010327 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1072459010328 FAD binding pocket [chemical binding]; other site 1072459010329 FAD binding motif [chemical binding]; other site 1072459010330 phosphate binding motif [ion binding]; other site 1072459010331 NAD binding pocket [chemical binding]; other site 1072459010332 Predicted transcriptional regulators [Transcription]; Region: COG1695 1072459010333 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1072459010334 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1072459010335 PAS fold; Region: PAS_3; pfam08447 1072459010336 putative active site [active] 1072459010337 heme pocket [chemical binding]; other site 1072459010338 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1072459010339 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1072459010340 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1072459010341 dimer interface [polypeptide binding]; other site 1072459010342 putative CheW interface [polypeptide binding]; other site 1072459010343 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 1072459010344 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1072459010345 inhibitor-cofactor binding pocket; inhibition site 1072459010346 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1072459010347 catalytic residue [active] 1072459010348 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 1072459010349 dimer interface [polypeptide binding]; other site 1072459010350 putative tRNA-binding site [nucleotide binding]; other site 1072459010351 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 1072459010352 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1072459010353 DNA binding site [nucleotide binding] 1072459010354 domain linker motif; other site 1072459010355 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 1072459010356 putative dimerization interface [polypeptide binding]; other site 1072459010357 putative ligand binding site [chemical binding]; other site 1072459010358 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 1072459010359 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1072459010360 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1072459010361 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1072459010362 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 1072459010363 cryptic beta-D-galactosidase subunit beta; Reviewed; Region: ebgC; PRK10202 1072459010364 inner membrane transporter YjeM; Provisional; Region: PRK15238 1072459010365 alpha-glucosidase; Provisional; Region: PRK10137 1072459010366 Protein of unknown function, DUF608; Region: DUF608; pfam04685 1072459010367 Trehalase; Region: Trehalase; cl17346 1072459010368 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1072459010369 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 1072459010370 active site 1072459010371 FMN binding site [chemical binding]; other site 1072459010372 2,4-decadienoyl-CoA binding site; other site 1072459010373 catalytic residue [active] 1072459010374 4Fe-4S cluster binding site [ion binding]; other site 1072459010375 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1072459010376 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 1072459010377 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1072459010378 S-adenosylmethionine binding site [chemical binding]; other site 1072459010379 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 1072459010380 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1072459010381 putative active site [active] 1072459010382 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1072459010383 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1072459010384 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1072459010385 serine/threonine transporter SstT; Provisional; Region: PRK13628 1072459010386 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1072459010387 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 1072459010388 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1072459010389 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1072459010390 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1072459010391 Glucuronate isomerase; Region: UxaC; pfam02614 1072459010392 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1072459010393 D-galactonate transporter; Region: 2A0114; TIGR00893 1072459010394 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459010395 putative substrate translocation pore; other site 1072459010396 CblD like pilus biogenesis initiator; Region: CblD; cl06460 1072459010397 fimbrial outer membrane usher protein TcfC; Provisional; Region: PRK15310 1072459010398 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1072459010399 CS1 type fimbrial major subunit; Region: Fimbrial_CS1; pfam04449 1072459010400 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1072459010401 putative fimbrial protein TcfA; Provisional; Region: PRK15308 1072459010402 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 1072459010403 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1072459010404 DNA-binding site [nucleotide binding]; DNA binding site 1072459010405 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1072459010406 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1072459010407 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1072459010408 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 1072459010409 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 1072459010410 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 1072459010411 Predicted membrane protein [Function unknown]; Region: COG5393 1072459010412 YqjK-like protein; Region: YqjK; pfam13997 1072459010413 Predicted membrane protein [Function unknown]; Region: COG2259 1072459010414 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1072459010415 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 1072459010416 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1072459010417 putative dimer interface [polypeptide binding]; other site 1072459010418 N-terminal domain interface [polypeptide binding]; other site 1072459010419 putative substrate binding pocket (H-site) [chemical binding]; other site 1072459010420 Predicted membrane protein [Function unknown]; Region: COG3152 1072459010421 Predicted membrane protein [Function unknown]; Region: COG3152 1072459010422 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1072459010423 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1072459010424 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1072459010425 dimerization interface [polypeptide binding]; other site 1072459010426 Pirin-related protein [General function prediction only]; Region: COG1741 1072459010427 Pirin; Region: Pirin; pfam02678 1072459010428 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 1072459010429 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1072459010430 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 1072459010431 L-serine dehydratase TdcG; Provisional; Region: PRK15040 1072459010432 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1072459010433 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1072459010434 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1072459010435 homotrimer interaction site [polypeptide binding]; other site 1072459010436 putative active site [active] 1072459010437 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1072459010438 Pyruvate formate lyase 1; Region: PFL1; cd01678 1072459010439 coenzyme A binding site [chemical binding]; other site 1072459010440 active site 1072459010441 catalytic residues [active] 1072459010442 glycine loop; other site 1072459010443 propionate/acetate kinase; Provisional; Region: PRK12379 1072459010444 Acetokinase family; Region: Acetate_kinase; cl17229 1072459010445 threonine/serine transporter TdcC; Provisional; Region: PRK13629 1072459010446 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1072459010447 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1072459010448 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1072459010449 tetramer interface [polypeptide binding]; other site 1072459010450 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1072459010451 catalytic residue [active] 1072459010452 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 1072459010453 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1072459010454 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 1072459010455 putative substrate binding pocket [chemical binding]; other site 1072459010456 putative dimerization interface [polypeptide binding]; other site 1072459010457 DNA-binding transcriptional activator TdcR; Provisional; Region: PRK11424 1072459010458 hypothetical protein; Provisional; Region: PRK09716 1072459010459 glycerate kinase I; Provisional; Region: PRK10342 1072459010460 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 1072459010461 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1072459010462 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 1072459010463 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1072459010464 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1072459010465 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1072459010466 putative regulator PrlF; Provisional; Region: PRK09974 1072459010467 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1072459010468 Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663 1072459010469 DNA-binding transcriptional regulator AgaR; Provisional; Region: PRK09802 1072459010470 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1072459010471 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1072459010472 tagatose 6-phosphate aldolase subunit KbaZ; Provisional; Region: PRK15458 1072459010473 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1072459010474 active site 1072459010475 phosphorylation site [posttranslational modification] 1072459010476 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 1072459010477 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 1072459010478 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1072459010479 active pocket/dimerization site; other site 1072459010480 active site 1072459010481 phosphorylation site [posttranslational modification] 1072459010482 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1072459010483 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1072459010484 active site 1072459010485 dimer interface [polypeptide binding]; other site 1072459010486 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 1072459010487 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1072459010488 dimer interface [polypeptide binding]; other site 1072459010489 active site 1072459010490 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 1072459010491 putative active site [active] 1072459010492 tagatose-bisphosphate aldolase; Reviewed; Region: kbaY; PRK12738 1072459010493 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1072459010494 active site 1072459010495 intersubunit interface [polypeptide binding]; other site 1072459010496 zinc binding site [ion binding]; other site 1072459010497 Na+ binding site [ion binding]; other site 1072459010498 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1072459010499 active site 1072459010500 phosphorylation site [posttranslational modification] 1072459010501 PTS system N-acetylgalactosamine-specific transporter subunit IIC; Provisional; Region: PRK09757 1072459010502 PTS system N-acetylgalactosamine-specific transporter subunit IID; Provisional; Region: PRK09855 1072459010503 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1072459010504 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1072459010505 active site 1072459010506 trimer interface [polypeptide binding]; other site 1072459010507 allosteric site; other site 1072459010508 active site lid [active] 1072459010509 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1072459010510 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 1072459010511 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1072459010512 putative SAM binding site [chemical binding]; other site 1072459010513 putative homodimer interface [polypeptide binding]; other site 1072459010514 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1072459010515 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 1072459010516 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 1072459010517 putative ligand binding site [chemical binding]; other site 1072459010518 TIGR00252 family protein; Region: TIGR00252 1072459010519 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1072459010520 dimer interface [polypeptide binding]; other site 1072459010521 active site 1072459010522 outer membrane lipoprotein; Provisional; Region: PRK11023 1072459010523 BON domain; Region: BON; pfam04972 1072459010524 BON domain; Region: BON; pfam04972 1072459010525 Predicted permease; Region: DUF318; pfam03773 1072459010526 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 1072459010527 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1072459010528 NAD binding site [chemical binding]; other site 1072459010529 active site 1072459010530 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1072459010531 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1072459010532 proposed catalytic triad [active] 1072459010533 conserved cys residue [active] 1072459010534 hypothetical protein; Provisional; Region: PRK03467 1072459010535 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1072459010536 GIY-YIG motif/motif A; other site 1072459010537 putative active site [active] 1072459010538 putative metal binding site [ion binding]; other site 1072459010539 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1072459010540 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1072459010541 Coenzyme A binding pocket [chemical binding]; other site 1072459010542 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 1072459010543 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1072459010544 Peptidase family U32; Region: Peptidase_U32; pfam01136 1072459010545 putative protease; Provisional; Region: PRK15447 1072459010546 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1072459010547 hypothetical protein; Provisional; Region: PRK10508 1072459010548 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1072459010549 tryptophan permease; Provisional; Region: PRK10483 1072459010550 aromatic amino acid transport protein; Region: araaP; TIGR00837 1072459010551 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 1072459010552 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1072459010553 ATP binding site [chemical binding]; other site 1072459010554 Mg++ binding site [ion binding]; other site 1072459010555 motif III; other site 1072459010556 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1072459010557 nucleotide binding region [chemical binding]; other site 1072459010558 ATP-binding site [chemical binding]; other site 1072459010559 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 1072459010560 putative RNA binding site [nucleotide binding]; other site 1072459010561 lipoprotein NlpI; Provisional; Region: PRK11189 1072459010562 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1072459010563 binding surface 1072459010564 TPR motif; other site 1072459010565 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1072459010566 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1072459010567 RNase E interface [polypeptide binding]; other site 1072459010568 trimer interface [polypeptide binding]; other site 1072459010569 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1072459010570 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1072459010571 RNase E interface [polypeptide binding]; other site 1072459010572 trimer interface [polypeptide binding]; other site 1072459010573 active site 1072459010574 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1072459010575 putative nucleic acid binding region [nucleotide binding]; other site 1072459010576 G-X-X-G motif; other site 1072459010577 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1072459010578 RNA binding site [nucleotide binding]; other site 1072459010579 domain interface; other site 1072459010580 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1072459010581 16S/18S rRNA binding site [nucleotide binding]; other site 1072459010582 S13e-L30e interaction site [polypeptide binding]; other site 1072459010583 25S rRNA binding site [nucleotide binding]; other site 1072459010584 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 1072459010585 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1072459010586 RNA binding site [nucleotide binding]; other site 1072459010587 active site 1072459010588 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 1072459010589 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1072459010590 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1072459010591 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 1072459010592 translation initiation factor IF-2; Region: IF-2; TIGR00487 1072459010593 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1072459010594 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1072459010595 G1 box; other site 1072459010596 putative GEF interaction site [polypeptide binding]; other site 1072459010597 GTP/Mg2+ binding site [chemical binding]; other site 1072459010598 Switch I region; other site 1072459010599 G2 box; other site 1072459010600 G3 box; other site 1072459010601 Switch II region; other site 1072459010602 G4 box; other site 1072459010603 G5 box; other site 1072459010604 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1072459010605 Translation-initiation factor 2; Region: IF-2; pfam11987 1072459010606 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1072459010607 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 1072459010608 NusA N-terminal domain; Region: NusA_N; pfam08529 1072459010609 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1072459010610 RNA binding site [nucleotide binding]; other site 1072459010611 homodimer interface [polypeptide binding]; other site 1072459010612 NusA-like KH domain; Region: KH_5; pfam13184 1072459010613 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1072459010614 G-X-X-G motif; other site 1072459010615 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1072459010616 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1072459010617 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1072459010618 Sm and related proteins; Region: Sm_like; cl00259 1072459010619 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1072459010620 putative oligomer interface [polypeptide binding]; other site 1072459010621 putative RNA binding site [nucleotide binding]; other site 1072459010622 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1072459010623 ANP binding site [chemical binding]; other site 1072459010624 Substrate Binding Site II [chemical binding]; other site 1072459010625 Substrate Binding Site I [chemical binding]; other site 1072459010626 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 1072459010627 Sulfatase; Region: Sulfatase; pfam00884 1072459010628 Preprotein translocase SecG subunit; Region: SecG; pfam03840 1072459010629 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 1072459010630 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1072459010631 active site 1072459010632 substrate binding site [chemical binding]; other site 1072459010633 metal binding site [ion binding]; metal-binding site 1072459010634 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1072459010635 dihydropteroate synthase; Region: DHPS; TIGR01496 1072459010636 substrate binding pocket [chemical binding]; other site 1072459010637 dimer interface [polypeptide binding]; other site 1072459010638 inhibitor binding site; inhibition site 1072459010639 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 1072459010640 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1072459010641 Walker A motif; other site 1072459010642 ATP binding site [chemical binding]; other site 1072459010643 Walker B motif; other site 1072459010644 arginine finger; other site 1072459010645 Peptidase family M41; Region: Peptidase_M41; pfam01434 1072459010646 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 1072459010647 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1072459010648 S-adenosylmethionine binding site [chemical binding]; other site 1072459010649 RNA-binding protein YhbY; Provisional; Region: PRK10343 1072459010650 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1072459010651 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1072459010652 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1072459010653 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 1072459010654 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1072459010655 GTPase CgtA; Reviewed; Region: obgE; PRK12298 1072459010656 GTP1/OBG; Region: GTP1_OBG; pfam01018 1072459010657 Obg GTPase; Region: Obg; cd01898 1072459010658 G1 box; other site 1072459010659 GTP/Mg2+ binding site [chemical binding]; other site 1072459010660 Switch I region; other site 1072459010661 G2 box; other site 1072459010662 G3 box; other site 1072459010663 Switch II region; other site 1072459010664 G4 box; other site 1072459010665 G5 box; other site 1072459010666 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1072459010667 EamA-like transporter family; Region: EamA; pfam00892 1072459010668 EamA-like transporter family; Region: EamA; pfam00892 1072459010669 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1072459010670 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1072459010671 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1072459010672 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1072459010673 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1072459010674 substrate binding pocket [chemical binding]; other site 1072459010675 chain length determination region; other site 1072459010676 substrate-Mg2+ binding site; other site 1072459010677 catalytic residues [active] 1072459010678 aspartate-rich region 1; other site 1072459010679 active site lid residues [active] 1072459010680 aspartate-rich region 2; other site 1072459010681 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 1072459010682 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1072459010683 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1072459010684 hinge; other site 1072459010685 active site 1072459010686 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 1072459010687 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1072459010688 anti sigma factor interaction site; other site 1072459010689 regulatory phosphorylation site [posttranslational modification]; other site 1072459010690 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 1072459010691 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1072459010692 mce related protein; Region: MCE; pfam02470 1072459010693 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1072459010694 conserved hypothetical integral membrane protein; Region: TIGR00056 1072459010695 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 1072459010696 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1072459010697 Walker A/P-loop; other site 1072459010698 ATP binding site [chemical binding]; other site 1072459010699 Q-loop/lid; other site 1072459010700 ABC transporter signature motif; other site 1072459010701 Walker B; other site 1072459010702 D-loop; other site 1072459010703 H-loop/switch region; other site 1072459010704 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 1072459010705 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1072459010706 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1072459010707 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 1072459010708 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1072459010709 putative active site [active] 1072459010710 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1072459010711 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 1072459010712 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 1072459010713 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 1072459010714 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 1072459010715 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 1072459010716 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 1072459010717 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 1072459010718 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1072459010719 Walker A/P-loop; other site 1072459010720 ATP binding site [chemical binding]; other site 1072459010721 Q-loop/lid; other site 1072459010722 ABC transporter signature motif; other site 1072459010723 Walker B; other site 1072459010724 D-loop; other site 1072459010725 H-loop/switch region; other site 1072459010726 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1072459010727 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1072459010728 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1072459010729 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1072459010730 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1072459010731 30S subunit binding site; other site 1072459010732 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1072459010733 active site 1072459010734 phosphorylation site [posttranslational modification] 1072459010735 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 1072459010736 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1072459010737 dimerization domain swap beta strand [polypeptide binding]; other site 1072459010738 regulatory protein interface [polypeptide binding]; other site 1072459010739 active site 1072459010740 regulatory phosphorylation site [posttranslational modification]; other site 1072459010741 hypothetical protein; Provisional; Region: PRK10345 1072459010742 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 1072459010743 Transglycosylase; Region: Transgly; cl17702 1072459010744 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 1072459010745 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 1072459010746 conserved cys residue [active] 1072459010747 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 1072459010748 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1072459010749 putative active site [active] 1072459010750 heme pocket [chemical binding]; other site 1072459010751 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1072459010752 dimer interface [polypeptide binding]; other site 1072459010753 phosphorylation site [posttranslational modification] 1072459010754 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1072459010755 ATP binding site [chemical binding]; other site 1072459010756 Mg2+ binding site [ion binding]; other site 1072459010757 G-X-G motif; other site 1072459010758 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1072459010759 active site 1072459010760 phosphorylation site [posttranslational modification] 1072459010761 intermolecular recognition site; other site 1072459010762 dimerization interface [polypeptide binding]; other site 1072459010763 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1072459010764 putative binding surface; other site 1072459010765 active site 1072459010766 radical SAM protein, TIGR01212 family; Region: TIGR01212 1072459010767 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1072459010768 FeS/SAM binding site; other site 1072459010769 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1072459010770 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1072459010771 active site 1072459010772 dimer interface [polypeptide binding]; other site 1072459010773 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1072459010774 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1072459010775 active site 1072459010776 FMN binding site [chemical binding]; other site 1072459010777 substrate binding site [chemical binding]; other site 1072459010778 3Fe-4S cluster binding site [ion binding]; other site 1072459010779 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1072459010780 domain interface; other site 1072459010781 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 1072459010782 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1072459010783 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1072459010784 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 1072459010785 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 1072459010786 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 1072459010787 N-acetylmannosamine kinase; Provisional; Region: PRK05082 1072459010788 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1072459010789 nucleotide binding site [chemical binding]; other site 1072459010790 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1072459010791 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 1072459010792 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1072459010793 putative active site cavity [active] 1072459010794 putative sialic acid transporter; Provisional; Region: PRK03893 1072459010795 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459010796 putative substrate translocation pore; other site 1072459010797 N-acetylneuraminate lyase; Region: nanA; TIGR00683 1072459010798 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 1072459010799 inhibitor site; inhibition site 1072459010800 active site 1072459010801 dimer interface [polypeptide binding]; other site 1072459010802 catalytic residue [active] 1072459010803 transcriptional regulator NanR; Provisional; Region: PRK03837 1072459010804 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1072459010805 DNA-binding site [nucleotide binding]; DNA binding site 1072459010806 FCD domain; Region: FCD; pfam07729 1072459010807 putative cryptic C4-dicarboxylate transporter DcuD; Provisional; Region: PRK09804 1072459010808 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1072459010809 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 1072459010810 stringent starvation protein A; Provisional; Region: sspA; PRK09481 1072459010811 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 1072459010812 C-terminal domain interface [polypeptide binding]; other site 1072459010813 putative GSH binding site (G-site) [chemical binding]; other site 1072459010814 dimer interface [polypeptide binding]; other site 1072459010815 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 1072459010816 dimer interface [polypeptide binding]; other site 1072459010817 N-terminal domain interface [polypeptide binding]; other site 1072459010818 Family of unknown function (DUF695); Region: DUF695; pfam05117 1072459010819 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 1072459010820 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1072459010821 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1072459010822 23S rRNA interface [nucleotide binding]; other site 1072459010823 L3 interface [polypeptide binding]; other site 1072459010824 Predicted ATPase [General function prediction only]; Region: COG1485 1072459010825 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 1072459010826 hypothetical protein; Provisional; Region: PRK11677 1072459010827 serine endoprotease; Provisional; Region: PRK10139 1072459010828 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1072459010829 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1072459010830 protein binding site [polypeptide binding]; other site 1072459010831 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1072459010832 serine endoprotease; Provisional; Region: PRK10898 1072459010833 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1072459010834 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1072459010835 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 1072459010836 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1072459010837 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1072459010838 malate dehydrogenase; Provisional; Region: PRK05086 1072459010839 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 1072459010840 NAD binding site [chemical binding]; other site 1072459010841 dimerization interface [polypeptide binding]; other site 1072459010842 Substrate binding site [chemical binding]; other site 1072459010843 arginine repressor; Provisional; Region: PRK05066 1072459010844 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1072459010845 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1072459010846 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1072459010847 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 1072459010848 RNAase interaction site [polypeptide binding]; other site 1072459010849 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 1072459010850 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1072459010851 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 1072459010852 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1072459010853 HlyD family secretion protein; Region: HlyD_3; pfam13437 1072459010854 efflux system membrane protein; Provisional; Region: PRK11594 1072459010855 transcriptional regulator; Provisional; Region: PRK10632 1072459010856 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1072459010857 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1072459010858 putative effector binding pocket; other site 1072459010859 dimerization interface [polypeptide binding]; other site 1072459010860 protease TldD; Provisional; Region: tldD; PRK10735 1072459010861 hypothetical protein; Provisional; Region: PRK10899 1072459010862 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1072459010863 ribonuclease G; Provisional; Region: PRK11712 1072459010864 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1072459010865 homodimer interface [polypeptide binding]; other site 1072459010866 oligonucleotide binding site [chemical binding]; other site 1072459010867 Maf-like protein; Region: Maf; pfam02545 1072459010868 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1072459010869 active site 1072459010870 dimer interface [polypeptide binding]; other site 1072459010871 rod shape-determining protein MreD; Provisional; Region: PRK11060 1072459010872 rod shape-determining protein MreC; Region: mreC; TIGR00219 1072459010873 rod shape-determining protein MreC; Region: MreC; pfam04085 1072459010874 rod shape-determining protein MreB; Provisional; Region: PRK13927 1072459010875 MreB and similar proteins; Region: MreB_like; cd10225 1072459010876 nucleotide binding site [chemical binding]; other site 1072459010877 Mg binding site [ion binding]; other site 1072459010878 putative protofilament interaction site [polypeptide binding]; other site 1072459010879 RodZ interaction site [polypeptide binding]; other site 1072459010880 regulatory protein CsrD; Provisional; Region: PRK11059 1072459010881 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1072459010882 metal binding site [ion binding]; metal-binding site 1072459010883 active site 1072459010884 I-site; other site 1072459010885 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1072459010886 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 1072459010887 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1072459010888 NADP binding site [chemical binding]; other site 1072459010889 dimer interface [polypeptide binding]; other site 1072459010890 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1072459010891 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1072459010892 carboxyltransferase (CT) interaction site; other site 1072459010893 biotinylation site [posttranslational modification]; other site 1072459010894 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1072459010895 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1072459010896 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1072459010897 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1072459010898 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 1072459010899 active site 1072459010900 catalytic residues [active] 1072459010901 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1072459010902 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1072459010903 substrate binding site [chemical binding]; other site 1072459010904 ATP binding site [chemical binding]; other site 1072459010905 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1072459010906 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1072459010907 TM-ABC transporter signature motif; other site 1072459010908 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1072459010909 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1072459010910 Walker A/P-loop; other site 1072459010911 ATP binding site [chemical binding]; other site 1072459010912 Q-loop/lid; other site 1072459010913 ABC transporter signature motif; other site 1072459010914 Walker B; other site 1072459010915 D-loop; other site 1072459010916 H-loop/switch region; other site 1072459010917 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1072459010918 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1072459010919 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_12; cd06322 1072459010920 putative ligand binding site [chemical binding]; other site 1072459010921 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1072459010922 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1072459010923 intersubunit interface [polypeptide binding]; other site 1072459010924 active site 1072459010925 zinc binding site [ion binding]; other site 1072459010926 Na+ binding site [ion binding]; other site 1072459010927 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1072459010928 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1072459010929 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1072459010930 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1072459010931 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1072459010932 substrate binding site [chemical binding]; other site 1072459010933 ATP binding site [chemical binding]; other site 1072459010934 hypothetical protein; Provisional; Region: PRK10633 1072459010935 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 1072459010936 Na binding site [ion binding]; other site 1072459010937 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1072459010938 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1072459010939 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 1072459010940 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1072459010941 FMN binding site [chemical binding]; other site 1072459010942 active site 1072459010943 catalytic residues [active] 1072459010944 substrate binding site [chemical binding]; other site 1072459010945 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 1072459010946 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 1072459010947 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1072459010948 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1072459010949 DNA methylase; Region: N6_N4_Mtase; pfam01555 1072459010950 Protein of unknown function (DUF2556); Region: DUF2556; pfam10831 1072459010951 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 1072459010952 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1072459010953 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 1072459010954 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 1072459010955 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1072459010956 HlyD family secretion protein; Region: HlyD_3; pfam13437 1072459010957 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1072459010958 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1072459010959 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1072459010960 substrate binding pocket [chemical binding]; other site 1072459010961 membrane-bound complex binding site; other site 1072459010962 hinge residues; other site 1072459010963 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 1072459010964 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1072459010965 conserved gate region; other site 1072459010966 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1072459010967 dimer interface [polypeptide binding]; other site 1072459010968 conserved gate region; other site 1072459010969 putative PBP binding loops; other site 1072459010970 ABC-ATPase subunit interface; other site 1072459010971 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1072459010972 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1072459010973 dimer interface [polypeptide binding]; other site 1072459010974 conserved gate region; other site 1072459010975 putative PBP binding loops; other site 1072459010976 ABC-ATPase subunit interface; other site 1072459010977 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1072459010978 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1072459010979 Walker A/P-loop; other site 1072459010980 ATP binding site [chemical binding]; other site 1072459010981 Q-loop/lid; other site 1072459010982 ABC transporter signature motif; other site 1072459010983 Walker B; other site 1072459010984 D-loop; other site 1072459010985 H-loop/switch region; other site 1072459010986 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1072459010987 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1072459010988 trimer interface [polypeptide binding]; other site 1072459010989 putative metal binding site [ion binding]; other site 1072459010990 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 1072459010991 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 1072459010992 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1072459010993 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1072459010994 shikimate binding site; other site 1072459010995 NAD(P) binding site [chemical binding]; other site 1072459010996 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 1072459010997 hypothetical protein; Validated; Region: PRK03430 1072459010998 hypothetical protein; Provisional; Region: PRK10736 1072459010999 DNA protecting protein DprA; Region: dprA; TIGR00732 1072459011000 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1072459011001 active site 1072459011002 catalytic residues [active] 1072459011003 metal binding site [ion binding]; metal-binding site 1072459011004 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1072459011005 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1072459011006 putative active site [active] 1072459011007 substrate binding site [chemical binding]; other site 1072459011008 putative cosubstrate binding site; other site 1072459011009 catalytic site [active] 1072459011010 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1072459011011 substrate binding site [chemical binding]; other site 1072459011012 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 1072459011013 putative RNA binding site [nucleotide binding]; other site 1072459011014 16S rRNA methyltransferase B; Provisional; Region: PRK10901 1072459011015 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1072459011016 S-adenosylmethionine binding site [chemical binding]; other site 1072459011017 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 1072459011018 TrkA-N domain; Region: TrkA_N; pfam02254 1072459011019 TrkA-C domain; Region: TrkA_C; pfam02080 1072459011020 TrkA-N domain; Region: TrkA_N; pfam02254 1072459011021 TrkA-C domain; Region: TrkA_C; pfam02080 1072459011022 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1072459011023 Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741 1072459011024 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 1072459011025 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 1072459011026 DNA binding residues [nucleotide binding] 1072459011027 dimer interface [polypeptide binding]; other site 1072459011028 metal binding site [ion binding]; metal-binding site 1072459011029 hypothetical protein; Provisional; Region: PRK10203 1072459011030 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1072459011031 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1072459011032 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1072459011033 alphaNTD homodimer interface [polypeptide binding]; other site 1072459011034 alphaNTD - beta interaction site [polypeptide binding]; other site 1072459011035 alphaNTD - beta' interaction site [polypeptide binding]; other site 1072459011036 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1072459011037 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1072459011038 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1072459011039 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1072459011040 RNA binding surface [nucleotide binding]; other site 1072459011041 30S ribosomal protein S11; Validated; Region: PRK05309 1072459011042 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1072459011043 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1072459011044 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 1072459011045 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1072459011046 SecY translocase; Region: SecY; pfam00344 1072459011047 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1072459011048 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1072459011049 23S rRNA binding site [nucleotide binding]; other site 1072459011050 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1072459011051 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1072459011052 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1072459011053 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1072459011054 23S rRNA interface [nucleotide binding]; other site 1072459011055 5S rRNA interface [nucleotide binding]; other site 1072459011056 L27 interface [polypeptide binding]; other site 1072459011057 L5 interface [polypeptide binding]; other site 1072459011058 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1072459011059 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1072459011060 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1072459011061 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1072459011062 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1072459011063 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1072459011064 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1072459011065 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1072459011066 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1072459011067 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1072459011068 RNA binding site [nucleotide binding]; other site 1072459011069 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1072459011070 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1072459011071 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1072459011072 23S rRNA interface [nucleotide binding]; other site 1072459011073 putative translocon interaction site; other site 1072459011074 signal recognition particle (SRP54) interaction site; other site 1072459011075 L23 interface [polypeptide binding]; other site 1072459011076 trigger factor interaction site; other site 1072459011077 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1072459011078 23S rRNA interface [nucleotide binding]; other site 1072459011079 5S rRNA interface [nucleotide binding]; other site 1072459011080 putative antibiotic binding site [chemical binding]; other site 1072459011081 L25 interface [polypeptide binding]; other site 1072459011082 L27 interface [polypeptide binding]; other site 1072459011083 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1072459011084 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1072459011085 G-X-X-G motif; other site 1072459011086 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1072459011087 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1072459011088 protein-rRNA interface [nucleotide binding]; other site 1072459011089 putative translocon binding site; other site 1072459011090 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1072459011091 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1072459011092 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1072459011093 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1072459011094 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1072459011095 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1072459011096 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 1072459011097 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1072459011098 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1072459011099 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1072459011100 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1072459011101 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1072459011102 heme binding site [chemical binding]; other site 1072459011103 ferroxidase pore; other site 1072459011104 ferroxidase diiron center [ion binding]; other site 1072459011105 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 1072459011106 elongation factor Tu; Reviewed; Region: PRK00049 1072459011107 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1072459011108 G1 box; other site 1072459011109 GEF interaction site [polypeptide binding]; other site 1072459011110 GTP/Mg2+ binding site [chemical binding]; other site 1072459011111 Switch I region; other site 1072459011112 G2 box; other site 1072459011113 G3 box; other site 1072459011114 Switch II region; other site 1072459011115 G4 box; other site 1072459011116 G5 box; other site 1072459011117 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1072459011118 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1072459011119 Antibiotic Binding Site [chemical binding]; other site 1072459011120 elongation factor G; Reviewed; Region: PRK00007 1072459011121 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1072459011122 G1 box; other site 1072459011123 putative GEF interaction site [polypeptide binding]; other site 1072459011124 GTP/Mg2+ binding site [chemical binding]; other site 1072459011125 Switch I region; other site 1072459011126 G2 box; other site 1072459011127 G3 box; other site 1072459011128 Switch II region; other site 1072459011129 G4 box; other site 1072459011130 G5 box; other site 1072459011131 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1072459011132 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1072459011133 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1072459011134 30S ribosomal protein S7; Validated; Region: PRK05302 1072459011135 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1072459011136 S17 interaction site [polypeptide binding]; other site 1072459011137 S8 interaction site; other site 1072459011138 16S rRNA interaction site [nucleotide binding]; other site 1072459011139 streptomycin interaction site [chemical binding]; other site 1072459011140 23S rRNA interaction site [nucleotide binding]; other site 1072459011141 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1072459011142 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 1072459011143 sulfur relay protein TusC; Validated; Region: PRK00211 1072459011144 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 1072459011145 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 1072459011146 YheO-like PAS domain; Region: PAS_6; pfam08348 1072459011147 HTH domain; Region: HTH_22; pfam13309 1072459011148 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 1072459011149 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1072459011150 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1072459011151 phi X174 lysis protein; Provisional; Region: PRK02793 1072459011152 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 1072459011153 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1072459011154 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 1072459011155 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 1072459011156 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 1072459011157 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1072459011158 Walker A/P-loop; other site 1072459011159 ATP binding site [chemical binding]; other site 1072459011160 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1072459011161 ABC transporter signature motif; other site 1072459011162 Walker B; other site 1072459011163 D-loop; other site 1072459011164 ABC transporter; Region: ABC_tran_2; pfam12848 1072459011165 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1072459011166 putative hydrolase; Provisional; Region: PRK10985 1072459011167 hypothetical protein; Provisional; Region: PRK04966 1072459011168 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 1072459011169 active site 1072459011170 hypothetical protein; Provisional; Region: PRK10738 1072459011171 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 1072459011172 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1072459011173 ligand binding site [chemical binding]; other site 1072459011174 flexible hinge region; other site 1072459011175 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1072459011176 putative switch regulator; other site 1072459011177 non-specific DNA interactions [nucleotide binding]; other site 1072459011178 DNA binding site [nucleotide binding] 1072459011179 sequence specific DNA binding site [nucleotide binding]; other site 1072459011180 putative cAMP binding site [chemical binding]; other site 1072459011181 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 1072459011182 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1072459011183 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1072459011184 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 1072459011185 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1072459011186 inhibitor-cofactor binding pocket; inhibition site 1072459011187 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1072459011188 catalytic residue [active] 1072459011189 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1072459011190 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1072459011191 glutamine binding [chemical binding]; other site 1072459011192 catalytic triad [active] 1072459011193 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 1072459011194 cell filamentation protein Fic; Provisional; Region: PRK10347 1072459011195 hypothetical protein; Provisional; Region: PRK10204 1072459011196 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 1072459011197 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1072459011198 substrate binding site [chemical binding]; other site 1072459011199 putative transporter; Provisional; Region: PRK03699 1072459011200 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459011201 putative substrate translocation pore; other site 1072459011202 nitrite reductase subunit NirD; Provisional; Region: PRK14989 1072459011203 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1072459011204 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1072459011205 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1072459011206 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1072459011207 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1072459011208 nitrite transporter NirC; Provisional; Region: PRK11562 1072459011209 siroheme synthase; Provisional; Region: cysG; PRK10637 1072459011210 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1072459011211 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 1072459011212 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1072459011213 active site 1072459011214 SAM binding site [chemical binding]; other site 1072459011215 homodimer interface [polypeptide binding]; other site 1072459011216 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 1072459011217 DNA topoisomerase III, bacteria and conjugative plasmid; Region: topB; TIGR01056 1072459011218 Protein of unknown function; Region: YhfT; pfam10797 1072459011219 Protein of unknown function DUF2620; Region: DUF2620; pfam10941 1072459011220 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1072459011221 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 1072459011222 active site 1072459011223 substrate binding pocket [chemical binding]; other site 1072459011224 homodimer interaction site [polypeptide binding]; other site 1072459011225 putative mutase; Provisional; Region: PRK12383 1072459011226 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; COG1015 1072459011227 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme yhfX; Region: PLPDE_III_yhfX_like; cd06811 1072459011228 dimer interface [polypeptide binding]; other site 1072459011229 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 1072459011230 active site 1072459011231 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1072459011232 substrate binding site [chemical binding]; other site 1072459011233 catalytic residue [active] 1072459011234 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 1072459011235 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1072459011236 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1072459011237 active site 1072459011238 HIGH motif; other site 1072459011239 dimer interface [polypeptide binding]; other site 1072459011240 KMSKS motif; other site 1072459011241 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1072459011242 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1072459011243 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1072459011244 motif II; other site 1072459011245 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1072459011246 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1072459011247 substrate binding site [chemical binding]; other site 1072459011248 hexamer interface [polypeptide binding]; other site 1072459011249 metal binding site [ion binding]; metal-binding site 1072459011250 DNA adenine methylase; Provisional; Region: PRK10904 1072459011251 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 1072459011252 cell division protein DamX; Validated; Region: PRK10905 1072459011253 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1072459011254 active site 1072459011255 dimer interface [polypeptide binding]; other site 1072459011256 metal binding site [ion binding]; metal-binding site 1072459011257 shikimate kinase; Reviewed; Region: aroK; PRK00131 1072459011258 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1072459011259 ADP binding site [chemical binding]; other site 1072459011260 magnesium binding site [ion binding]; other site 1072459011261 putative shikimate binding site; other site 1072459011262 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 1072459011263 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1072459011264 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1072459011265 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 1072459011266 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 1072459011267 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 1072459011268 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 1072459011269 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 1072459011270 Transglycosylase; Region: Transgly; pfam00912 1072459011271 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1072459011272 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 1072459011273 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1072459011274 ADP-ribose binding site [chemical binding]; other site 1072459011275 dimer interface [polypeptide binding]; other site 1072459011276 active site 1072459011277 nudix motif; other site 1072459011278 metal binding site [ion binding]; metal-binding site 1072459011279 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 1072459011280 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1072459011281 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1072459011282 motif II; other site 1072459011283 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1072459011284 RNA binding surface [nucleotide binding]; other site 1072459011285 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1072459011286 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1072459011287 dimerization interface [polypeptide binding]; other site 1072459011288 domain crossover interface; other site 1072459011289 redox-dependent activation switch; other site 1072459011290 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 1072459011291 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1072459011292 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1072459011293 active site 1072459011294 substrate-binding site [chemical binding]; other site 1072459011295 metal-binding site [ion binding] 1072459011296 ATP binding site [chemical binding]; other site 1072459011297 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 1072459011298 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1072459011299 non-specific DNA binding site [nucleotide binding]; other site 1072459011300 salt bridge; other site 1072459011301 sequence-specific DNA binding site [nucleotide binding]; other site 1072459011302 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 1072459011303 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1072459011304 dimerization interface [polypeptide binding]; other site 1072459011305 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1072459011306 dimer interface [polypeptide binding]; other site 1072459011307 phosphorylation site [posttranslational modification] 1072459011308 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1072459011309 ATP binding site [chemical binding]; other site 1072459011310 G-X-G motif; other site 1072459011311 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1072459011312 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1072459011313 active site 1072459011314 phosphorylation site [posttranslational modification] 1072459011315 intermolecular recognition site; other site 1072459011316 dimerization interface [polypeptide binding]; other site 1072459011317 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1072459011318 DNA binding site [nucleotide binding] 1072459011319 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 1072459011320 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1072459011321 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1072459011322 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1072459011323 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1072459011324 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1072459011325 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1072459011326 RNA binding site [nucleotide binding]; other site 1072459011327 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 1072459011328 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 1072459011329 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1072459011330 G1 box; other site 1072459011331 GTP/Mg2+ binding site [chemical binding]; other site 1072459011332 Switch I region; other site 1072459011333 G2 box; other site 1072459011334 G3 box; other site 1072459011335 Switch II region; other site 1072459011336 G4 box; other site 1072459011337 G5 box; other site 1072459011338 Nucleoside recognition; Region: Gate; pfam07670 1072459011339 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1072459011340 Nucleoside recognition; Region: Gate; pfam07670 1072459011341 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 1072459011342 putative transposase; Provisional; Region: PRK09857 1072459011343 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1072459011344 carboxylesterase BioH; Provisional; Region: PRK10349 1072459011345 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1072459011346 DNA utilization protein GntX; Provisional; Region: PRK11595 1072459011347 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1072459011348 active site 1072459011349 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 1072459011350 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1072459011351 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1072459011352 high-affinity gluconate transporter; Provisional; Region: PRK14984 1072459011353 gluconate transporter; Region: gntP; TIGR00791 1072459011354 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1072459011355 4-alpha-glucanotransferase; Region: malQ; TIGR00217 1072459011356 maltodextrin phosphorylase; Provisional; Region: PRK14985 1072459011357 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1072459011358 homodimer interface [polypeptide binding]; other site 1072459011359 active site pocket [active] 1072459011360 transcriptional regulator MalT; Provisional; Region: PRK04841 1072459011361 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1072459011362 DNA binding residues [nucleotide binding] 1072459011363 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 1072459011364 RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine...; Region: RNA_Cyclase_Class_II; cd00874 1072459011365 putative active site [active] 1072459011366 adenylation catalytic residue [active] 1072459011367 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 1072459011368 hypothetical protein; Reviewed; Region: PRK09588 1072459011369 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 1072459011370 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 1072459011371 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1072459011372 Walker A motif; other site 1072459011373 ATP binding site [chemical binding]; other site 1072459011374 Walker B motif; other site 1072459011375 arginine finger; other site 1072459011376 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 1072459011377 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1072459011378 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1072459011379 intramembrane serine protease GlpG; Provisional; Region: PRK10907 1072459011380 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 1072459011381 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1072459011382 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 1072459011383 active site residue [active] 1072459011384 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 1072459011385 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 1072459011386 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 1072459011387 glycogen phosphorylase; Provisional; Region: PRK14986 1072459011388 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1072459011389 homodimer interface [polypeptide binding]; other site 1072459011390 active site pocket [active] 1072459011391 glycogen synthase; Provisional; Region: glgA; PRK00654 1072459011392 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1072459011393 ADP-binding pocket [chemical binding]; other site 1072459011394 homodimer interface [polypeptide binding]; other site 1072459011395 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 1072459011396 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1072459011397 ligand binding site; other site 1072459011398 oligomer interface; other site 1072459011399 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1072459011400 sulfate 1 binding site; other site 1072459011401 glycogen debranching enzyme; Provisional; Region: PRK03705 1072459011402 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1072459011403 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1072459011404 active site 1072459011405 catalytic site [active] 1072459011406 glycogen branching enzyme; Provisional; Region: PRK05402 1072459011407 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1072459011408 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1072459011409 active site 1072459011410 catalytic site [active] 1072459011411 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1072459011412 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 1072459011413 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1072459011414 putative antibiotic transporter; Provisional; Region: PRK10739 1072459011415 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 1072459011416 DNA protecting protein DprA; Region: dprA; TIGR00732 1072459011417 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1072459011418 non-specific DNA interactions [nucleotide binding]; other site 1072459011419 DNA binding site [nucleotide binding] 1072459011420 sequence specific DNA binding site [nucleotide binding]; other site 1072459011421 putative cAMP binding site [chemical binding]; other site 1072459011422 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1072459011423 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1072459011424 ATP binding site [chemical binding]; other site 1072459011425 putative Mg++ binding site [ion binding]; other site 1072459011426 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1072459011427 nucleotide binding region [chemical binding]; other site 1072459011428 ATP-binding site [chemical binding]; other site 1072459011429 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1072459011430 active site 1072459011431 low affinity gluconate transporter; Provisional; Region: PRK10472 1072459011432 gluconate transporter; Region: gntP; TIGR00791 1072459011433 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1072459011434 ATP-binding site [chemical binding]; other site 1072459011435 Gluconate-6-phosphate binding site [chemical binding]; other site 1072459011436 Shikimate kinase; Region: SKI; pfam01202 1072459011437 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 1072459011438 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1072459011439 DNA binding site [nucleotide binding] 1072459011440 domain linker motif; other site 1072459011441 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1072459011442 putative ligand binding site [chemical binding]; other site 1072459011443 putative dimerization interface [polypeptide binding]; other site 1072459011444 Pirin-related protein [General function prediction only]; Region: COG1741 1072459011445 Pirin; Region: Pirin; pfam02678 1072459011446 putative oxidoreductase; Provisional; Region: PRK10206 1072459011447 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1072459011448 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1072459011449 putative acetyltransferase YhhY; Provisional; Region: PRK10140 1072459011450 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1072459011451 Coenzyme A binding pocket [chemical binding]; other site 1072459011452 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 1072459011453 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 1072459011454 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 1072459011455 hypothetical protein; Provisional; Region: PRK10350 1072459011456 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 1072459011457 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 1072459011458 putative active site [active] 1072459011459 catalytic site [active] 1072459011460 putative metal binding site [ion binding]; other site 1072459011461 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1072459011462 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1072459011463 Walker A/P-loop; other site 1072459011464 ATP binding site [chemical binding]; other site 1072459011465 Q-loop/lid; other site 1072459011466 ABC transporter signature motif; other site 1072459011467 Walker B; other site 1072459011468 D-loop; other site 1072459011469 H-loop/switch region; other site 1072459011470 TOBE domain; Region: TOBE_2; pfam08402 1072459011471 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1072459011472 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1072459011473 dimer interface [polypeptide binding]; other site 1072459011474 conserved gate region; other site 1072459011475 putative PBP binding loops; other site 1072459011476 ABC-ATPase subunit interface; other site 1072459011477 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1072459011478 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1072459011479 dimer interface [polypeptide binding]; other site 1072459011480 conserved gate region; other site 1072459011481 putative PBP binding loops; other site 1072459011482 ABC-ATPase subunit interface; other site 1072459011483 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 1072459011484 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1072459011485 Uncharacterized protein conserved in bacteria containing a divergent form of TPR repeats [Function unknown]; Region: COG4700 1072459011486 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1072459011487 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1072459011488 binding surface 1072459011489 TPR motif; other site 1072459011490 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 1072459011491 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1072459011492 Walker A/P-loop; other site 1072459011493 ATP binding site [chemical binding]; other site 1072459011494 Q-loop/lid; other site 1072459011495 ABC transporter signature motif; other site 1072459011496 Walker B; other site 1072459011497 D-loop; other site 1072459011498 H-loop/switch region; other site 1072459011499 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 1072459011500 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1072459011501 Walker A/P-loop; other site 1072459011502 ATP binding site [chemical binding]; other site 1072459011503 Q-loop/lid; other site 1072459011504 ABC transporter signature motif; other site 1072459011505 Walker B; other site 1072459011506 D-loop; other site 1072459011507 H-loop/switch region; other site 1072459011508 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 1072459011509 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 1072459011510 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1072459011511 TM-ABC transporter signature motif; other site 1072459011512 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1072459011513 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1072459011514 TM-ABC transporter signature motif; other site 1072459011515 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1072459011516 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1072459011517 dimerization interface [polypeptide binding]; other site 1072459011518 ligand binding site [chemical binding]; other site 1072459011519 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 1072459011520 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1072459011521 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1072459011522 dimerization interface [polypeptide binding]; other site 1072459011523 ligand binding site [chemical binding]; other site 1072459011524 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 1072459011525 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1072459011526 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1072459011527 DNA binding residues [nucleotide binding] 1072459011528 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1072459011529 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 1072459011530 cell division protein FtsE; Provisional; Region: PRK10908 1072459011531 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1072459011532 Walker A/P-loop; other site 1072459011533 ATP binding site [chemical binding]; other site 1072459011534 Q-loop/lid; other site 1072459011535 ABC transporter signature motif; other site 1072459011536 Walker B; other site 1072459011537 D-loop; other site 1072459011538 H-loop/switch region; other site 1072459011539 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1072459011540 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1072459011541 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1072459011542 P loop; other site 1072459011543 GTP binding site [chemical binding]; other site 1072459011544 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1072459011545 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1072459011546 S-adenosylmethionine binding site [chemical binding]; other site 1072459011547 hypothetical protein; Provisional; Region: PRK10910 1072459011548 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 1072459011549 Predicted membrane protein [Function unknown]; Region: COG3714 1072459011550 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 1072459011551 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1072459011552 metal-binding site [ion binding] 1072459011553 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1072459011554 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1072459011555 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 1072459011556 CPxP motif; other site 1072459011557 hypothetical protein; Provisional; Region: PRK11212 1072459011558 hypothetical protein; Provisional; Region: PRK11615 1072459011559 major facilitator superfamily transporter; Provisional; Region: PRK05122 1072459011560 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459011561 putative substrate translocation pore; other site 1072459011562 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1072459011563 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1072459011564 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 1072459011565 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1072459011566 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1072459011567 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 1072459011568 substrate binding site [chemical binding]; other site 1072459011569 nickel transporter permease NikB; Provisional; Region: PRK10352 1072459011570 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1072459011571 dimer interface [polypeptide binding]; other site 1072459011572 conserved gate region; other site 1072459011573 putative PBP binding loops; other site 1072459011574 ABC-ATPase subunit interface; other site 1072459011575 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 1072459011576 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1072459011577 dimer interface [polypeptide binding]; other site 1072459011578 conserved gate region; other site 1072459011579 putative PBP binding loops; other site 1072459011580 ABC-ATPase subunit interface; other site 1072459011581 nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418 1072459011582 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1072459011583 Walker A/P-loop; other site 1072459011584 ATP binding site [chemical binding]; other site 1072459011585 Q-loop/lid; other site 1072459011586 ABC transporter signature motif; other site 1072459011587 Walker B; other site 1072459011588 D-loop; other site 1072459011589 H-loop/switch region; other site 1072459011590 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1072459011591 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 1072459011592 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1072459011593 Walker A/P-loop; other site 1072459011594 ATP binding site [chemical binding]; other site 1072459011595 Q-loop/lid; other site 1072459011596 ABC transporter signature motif; other site 1072459011597 Walker B; other site 1072459011598 D-loop; other site 1072459011599 H-loop/switch region; other site 1072459011600 nickel responsive regulator; Provisional; Region: PRK02967 1072459011601 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 1072459011602 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1072459011603 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1072459011604 DNA-binding site [nucleotide binding]; DNA binding site 1072459011605 UTRA domain; Region: UTRA; pfam07702 1072459011606 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1072459011607 active site 1072459011608 phosphorylation site [posttranslational modification] 1072459011609 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1072459011610 active site 1072459011611 P-loop; other site 1072459011612 phosphorylation site [posttranslational modification] 1072459011613 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 1072459011614 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1072459011615 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1072459011616 uncharacterized subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_1; cd07774 1072459011617 putative N- and C-terminal domain interface [polypeptide binding]; other site 1072459011618 putative active site [active] 1072459011619 putative MgATP binding site [chemical binding]; other site 1072459011620 catalytic site [active] 1072459011621 metal binding site [ion binding]; metal-binding site 1072459011622 putative carbohydrate binding site [chemical binding]; other site 1072459011623 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1072459011624 dimerization domain swap beta strand [polypeptide binding]; other site 1072459011625 regulatory protein interface [polypeptide binding]; other site 1072459011626 active site 1072459011627 regulatory phosphorylation site [posttranslational modification]; other site 1072459011628 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1072459011629 intersubunit interface [polypeptide binding]; other site 1072459011630 active site 1072459011631 zinc binding site [ion binding]; other site 1072459011632 Na+ binding site [ion binding]; other site 1072459011633 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 1072459011634 HicB family; Region: HicB; pfam05534 1072459011635 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1072459011636 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1072459011637 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1072459011638 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1072459011639 Walker A/P-loop; other site 1072459011640 ATP binding site [chemical binding]; other site 1072459011641 Q-loop/lid; other site 1072459011642 ABC transporter signature motif; other site 1072459011643 Walker B; other site 1072459011644 D-loop; other site 1072459011645 H-loop/switch region; other site 1072459011646 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1072459011647 Walker A/P-loop; other site 1072459011648 ATP binding site [chemical binding]; other site 1072459011649 Q-loop/lid; other site 1072459011650 ABC transporter signature motif; other site 1072459011651 Walker B; other site 1072459011652 D-loop; other site 1072459011653 H-loop/switch region; other site 1072459011654 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1072459011655 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1072459011656 HlyD family secretion protein; Region: HlyD; pfam00529 1072459011657 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1072459011658 HlyD family secretion protein; Region: HlyD_3; pfam13437 1072459011659 Domain of unknown function (DUF4049); Region: DUF4049; pfam13258 1072459011660 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 1072459011661 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1072459011662 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1072459011663 Domain of unknown function (DUF4049); Region: DUF4049; pfam13258 1072459011664 Protein of unknown function (DUF2776); Region: DUF2776; pfam10951 1072459011665 Predicted flavoproteins [General function prediction only]; Region: COG2081 1072459011666 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1072459011667 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1072459011668 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1072459011669 universal stress protein UspB; Provisional; Region: PRK04960 1072459011670 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1072459011671 Ligand Binding Site [chemical binding]; other site 1072459011672 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 1072459011673 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459011674 POT family; Region: PTR2; pfam00854 1072459011675 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1072459011676 S-adenosylmethionine binding site [chemical binding]; other site 1072459011677 oligopeptidase A; Provisional; Region: PRK10911 1072459011678 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1072459011679 active site 1072459011680 Zn binding site [ion binding]; other site 1072459011681 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 1072459011682 glutathione reductase; Validated; Region: PRK06116 1072459011683 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1072459011684 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1072459011685 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1072459011686 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1072459011687 dimerization interface [polypeptide binding]; other site 1072459011688 putative DNA binding site [nucleotide binding]; other site 1072459011689 putative Zn2+ binding site [ion binding]; other site 1072459011690 arsenical pump membrane protein; Provisional; Region: PRK15445 1072459011691 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1072459011692 transmembrane helices; other site 1072459011693 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1072459011694 ArsC family; Region: ArsC; pfam03960 1072459011695 catalytic residues [active] 1072459011696 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1072459011697 dimerization interface [polypeptide binding]; other site 1072459011698 putative DNA binding site [nucleotide binding]; other site 1072459011699 putative Zn2+ binding site [ion binding]; other site 1072459011700 Predicted permeases [General function prediction only]; Region: COG0701 1072459011701 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 1072459011702 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1072459011703 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1072459011704 DNA binding residues [nucleotide binding] 1072459011705 dimerization interface [polypeptide binding]; other site 1072459011706 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 1072459011707 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 1072459011708 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 1072459011709 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 1072459011710 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1072459011711 N-terminal plug; other site 1072459011712 ligand-binding site [chemical binding]; other site 1072459011713 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 1072459011714 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 1072459011715 putative hemin binding site; other site 1072459011716 coproporphyrinogen III oxidase; Provisional; Region: PRK09058 1072459011717 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1072459011718 FeS/SAM binding site; other site 1072459011719 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugX; COG3721 1072459011720 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1072459011721 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1072459011722 NAD(P) binding site [chemical binding]; other site 1072459011723 putative active site [active] 1072459011724 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1072459011725 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1072459011726 ABC-ATPase subunit interface; other site 1072459011727 dimer interface [polypeptide binding]; other site 1072459011728 putative PBP binding regions; other site 1072459011729 ABC-type hemin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG4559 1072459011730 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1072459011731 Walker A/P-loop; other site 1072459011732 ATP binding site [chemical binding]; other site 1072459011733 Q-loop/lid; other site 1072459011734 ABC transporter signature motif; other site 1072459011735 Walker B; other site 1072459011736 D-loop; other site 1072459011737 H-loop/switch region; other site 1072459011738 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 1072459011739 MgtC family; Region: MgtC; pfam02308 1072459011740 acid-resistance protein; Provisional; Region: hdeB; PRK11566 1072459011741 acid-resistance protein; Provisional; Region: PRK10208 1072459011742 acid-resistance membrane protein; Provisional; Region: PRK10209 1072459011743 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1072459011744 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1072459011745 pyruvate kinase; Provisional; Region: PRK05826 1072459011746 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 1072459011747 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1072459011748 HlyD family secretion protein; Region: HlyD_3; pfam13437 1072459011749 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 1072459011750 Protein export membrane protein; Region: SecD_SecF; cl14618 1072459011751 transcriptional regulator YdeO; Provisional; Region: PRK09940 1072459011752 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1072459011753 DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978 1072459011754 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1072459011755 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1072459011756 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1072459011757 catalytic residue [active] 1072459011758 Haem-binding domain; Region: Haem_bd; pfam14376 1072459011759 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 1072459011760 CHASE domain; Region: CHASE; cl01369 1072459011761 trehalase; Provisional; Region: treF; PRK13270 1072459011762 Trehalase; Region: Trehalase; pfam01204 1072459011763 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1072459011764 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1072459011765 DNA binding residues [nucleotide binding] 1072459011766 dimerization interface [polypeptide binding]; other site 1072459011767 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1072459011768 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1072459011769 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1072459011770 putative effector binding pocket; other site 1072459011771 putative dimerization interface [polypeptide binding]; other site 1072459011772 inner membrane protein YhjD; Region: TIGR00766 1072459011773 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459011774 metabolite-proton symporter; Region: 2A0106; TIGR00883 1072459011775 putative substrate translocation pore; other site 1072459011776 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 1072459011777 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1072459011778 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1072459011779 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1072459011780 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1072459011781 substrate binding site [chemical binding]; other site 1072459011782 ATP binding site [chemical binding]; other site 1072459011783 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1072459011784 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1072459011785 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1072459011786 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1072459011787 putative diguanylate cyclase; Provisional; Region: PRK13561 1072459011788 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1072459011789 metal binding site [ion binding]; metal-binding site 1072459011790 active site 1072459011791 I-site; other site 1072459011792 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1072459011793 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 1072459011794 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1072459011795 binding surface 1072459011796 TPR motif; other site 1072459011797 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1072459011798 binding surface 1072459011799 TPR motif; other site 1072459011800 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 1072459011801 endo-1,4-D-glucanase; Provisional; Region: PRK11097 1072459011802 cellulose synthase regulator protein; Provisional; Region: PRK11114 1072459011803 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 1072459011804 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1072459011805 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 1072459011806 DXD motif; other site 1072459011807 PilZ domain; Region: PilZ; pfam07238 1072459011808 cell division protein; Provisional; Region: PRK10037 1072459011809 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 1072459011810 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 1072459011811 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 1072459011812 celllulose biosynthesis operon protein BcsF/YhjT; Region: cellullose_BcsF; TIGR03493 1072459011813 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 1072459011814 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1072459011815 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1072459011816 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 1072459011817 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 1072459011818 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1072459011819 serine transporter; Region: stp; TIGR00814 1072459011820 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1072459011821 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1072459011822 Walker A/P-loop; other site 1072459011823 ATP binding site [chemical binding]; other site 1072459011824 Q-loop/lid; other site 1072459011825 ABC transporter signature motif; other site 1072459011826 Walker B; other site 1072459011827 D-loop; other site 1072459011828 H-loop/switch region; other site 1072459011829 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1072459011830 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 1072459011831 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1072459011832 Walker A/P-loop; other site 1072459011833 ATP binding site [chemical binding]; other site 1072459011834 Q-loop/lid; other site 1072459011835 ABC transporter signature motif; other site 1072459011836 Walker B; other site 1072459011837 D-loop; other site 1072459011838 H-loop/switch region; other site 1072459011839 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1072459011840 dipeptide transporter; Provisional; Region: PRK10913 1072459011841 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1072459011842 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1072459011843 dimer interface [polypeptide binding]; other site 1072459011844 conserved gate region; other site 1072459011845 putative PBP binding loops; other site 1072459011846 ABC-ATPase subunit interface; other site 1072459011847 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1072459011848 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1072459011849 dimer interface [polypeptide binding]; other site 1072459011850 conserved gate region; other site 1072459011851 putative PBP binding loops; other site 1072459011852 ABC-ATPase subunit interface; other site 1072459011853 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1072459011854 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1072459011855 peptide binding site [polypeptide binding]; other site 1072459011856 phosphoethanolamine transferase; Provisional; Region: PRK11560 1072459011857 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1072459011858 Sulfatase; Region: Sulfatase; pfam00884 1072459011859 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 1072459011860 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459011861 putative substrate translocation pore; other site 1072459011862 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 1072459011863 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 1072459011864 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1072459011865 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1072459011866 Coenzyme A binding pocket [chemical binding]; other site 1072459011867 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 1072459011868 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1072459011869 molybdopterin cofactor binding site [chemical binding]; other site 1072459011870 substrate binding site [chemical binding]; other site 1072459011871 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 1072459011872 molybdopterin cofactor binding site; other site 1072459011873 putative outer membrane lipoprotein; Provisional; Region: PRK10510 1072459011874 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1072459011875 ligand binding site [chemical binding]; other site 1072459011876 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 1072459011877 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1072459011878 dimerization interface [polypeptide binding]; other site 1072459011879 ligand binding site [chemical binding]; other site 1072459011880 NADP binding site [chemical binding]; other site 1072459011881 catalytic site [active] 1072459011882 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 1072459011883 Predicted transcriptional regulator [Transcription]; Region: COG2944 1072459011884 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1072459011885 non-specific DNA binding site [nucleotide binding]; other site 1072459011886 salt bridge; other site 1072459011887 sequence-specific DNA binding site [nucleotide binding]; other site 1072459011888 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1072459011889 DNA-binding site [nucleotide binding]; DNA binding site 1072459011890 RNA-binding motif; other site 1072459011891 small toxic polypeptide; Provisional; Region: PRK09759 1072459011892 putative transposase OrfB; Reviewed; Region: PHA02517 1072459011893 HTH-like domain; Region: HTH_21; pfam13276 1072459011894 Integrase core domain; Region: rve; pfam00665 1072459011895 Integrase core domain; Region: rve_2; pfam13333 1072459011896 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1072459011897 Helix-turn-helix domain; Region: HTH_28; pfam13518 1072459011898 Helix-turn-helix domain; Region: HTH_28; pfam13518 1072459011899 glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211 1072459011900 DALR anticodon binding domain; Region: DALR_1; pfam05746 1072459011901 anticodon binding site; other site 1072459011902 tRNA binding surface [nucleotide binding]; other site 1072459011903 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1072459011904 dimer interface [polypeptide binding]; other site 1072459011905 motif 1; other site 1072459011906 active site 1072459011907 motif 2; other site 1072459011908 motif 3; other site 1072459011909 YsaB-like lipoprotein; Region: YsaB; pfam13983 1072459011910 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 1072459011911 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1072459011912 hypothetical protein; Provisional; Region: PRK11383 1072459011913 yiaA/B two helix domain; Region: YiaAB; pfam05360 1072459011914 yiaA/B two helix domain; Region: YiaAB; pfam05360 1072459011915 xylulokinase; Provisional; Region: PRK15027 1072459011916 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1072459011917 N- and C-terminal domain interface [polypeptide binding]; other site 1072459011918 active site 1072459011919 MgATP binding site [chemical binding]; other site 1072459011920 catalytic site [active] 1072459011921 metal binding site [ion binding]; metal-binding site 1072459011922 xylulose binding site [chemical binding]; other site 1072459011923 homodimer interface [polypeptide binding]; other site 1072459011924 xylose isomerase; Provisional; Region: PRK05474 1072459011925 xylose isomerase; Region: xylose_isom_A; TIGR02630 1072459011926 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 1072459011927 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 1072459011928 putative ligand binding site [chemical binding]; other site 1072459011929 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 1072459011930 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1072459011931 Walker A/P-loop; other site 1072459011932 ATP binding site [chemical binding]; other site 1072459011933 Q-loop/lid; other site 1072459011934 ABC transporter signature motif; other site 1072459011935 Walker B; other site 1072459011936 D-loop; other site 1072459011937 H-loop/switch region; other site 1072459011938 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1072459011939 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1072459011940 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1072459011941 TM-ABC transporter signature motif; other site 1072459011942 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 1072459011943 putative dimerization interface [polypeptide binding]; other site 1072459011944 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1072459011945 putative ligand binding site [chemical binding]; other site 1072459011946 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1072459011947 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1072459011948 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1072459011949 hypothetical protein; Provisional; Region: PRK10356 1072459011950 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 1072459011951 alpha-amylase; Reviewed; Region: malS; PRK09505 1072459011952 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1072459011953 active site 1072459011954 catalytic site [active] 1072459011955 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 1072459011956 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1072459011957 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1072459011958 homodimer interface [polypeptide binding]; other site 1072459011959 catalytic residue [active] 1072459011960 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 1072459011961 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1072459011962 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1072459011963 Bacterial transcriptional regulator; Region: IclR; pfam01614 1072459011964 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 1072459011965 uncharacterized protein, YhcH/YjgK/YiaL family; Region: TIGR00022 1072459011966 2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM; Provisional; Region: PRK09877 1072459011967 L-dehydroascorbate transporter large permease subunit; Provisional; Region: PRK15060 1072459011968 DctM-like transporters; Region: DctM; pfam06808 1072459011969 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1072459011970 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 1072459011971 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1072459011972 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 1072459011973 putative N- and C-terminal domain interface [polypeptide binding]; other site 1072459011974 putative active site [active] 1072459011975 MgATP binding site [chemical binding]; other site 1072459011976 catalytic site [active] 1072459011977 metal binding site [ion binding]; metal-binding site 1072459011978 putative xylulose binding site [chemical binding]; other site 1072459011979 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1072459011980 active site 1072459011981 dimer interface [polypeptide binding]; other site 1072459011982 magnesium binding site [ion binding]; other site 1072459011983 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 1072459011984 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1072459011985 AP (apurinic/apyrimidinic) site pocket; other site 1072459011986 DNA interaction; other site 1072459011987 Metal-binding active site; metal-binding site 1072459011988 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1072459011989 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1072459011990 intersubunit interface [polypeptide binding]; other site 1072459011991 active site 1072459011992 Zn2+ binding site [ion binding]; other site 1072459011993 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1072459011994 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1072459011995 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1072459011996 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1072459011997 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1072459011998 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 1072459011999 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 1072459012000 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 1072459012001 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 1072459012002 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1072459012003 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1072459012004 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1072459012005 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1072459012006 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1072459012007 HlyD family secretion protein; Region: HlyD_3; pfam13437 1072459012008 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 1072459012009 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 1072459012010 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1072459012011 NAD(P) binding site [chemical binding]; other site 1072459012012 catalytic residues [active] 1072459012013 Fic family protein [Function unknown]; Region: COG3177 1072459012014 Fic/DOC family; Region: Fic; pfam02661 1072459012015 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1072459012016 putative alcohol dehydrogenase; Provisional; Region: PRK09860 1072459012017 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 1072459012018 dimer interface [polypeptide binding]; other site 1072459012019 active site 1072459012020 metal binding site [ion binding]; metal-binding site 1072459012021 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 1072459012022 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 1072459012023 G1 box; other site 1072459012024 putative GEF interaction site [polypeptide binding]; other site 1072459012025 GTP/Mg2+ binding site [chemical binding]; other site 1072459012026 Switch I region; other site 1072459012027 G2 box; other site 1072459012028 G3 box; other site 1072459012029 Switch II region; other site 1072459012030 G4 box; other site 1072459012031 G5 box; other site 1072459012032 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 1072459012033 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 1072459012034 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 1072459012035 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 1072459012036 selenocysteine synthase; Provisional; Region: PRK04311 1072459012037 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 1072459012038 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 1072459012039 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1072459012040 catalytic residue [active] 1072459012041 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 1072459012042 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 1072459012043 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1072459012044 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1072459012045 active site 1072459012046 P-loop; other site 1072459012047 phosphorylation site [posttranslational modification] 1072459012048 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1072459012049 active site 1072459012050 phosphorylation site [posttranslational modification] 1072459012051 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 1072459012052 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1072459012053 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1072459012054 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 1072459012055 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 1072459012056 hypothetical protein; Provisional; Region: PRK11020 1072459012057 Protein of unknown function (DUF3251); Region: DUF3251; cl08186 1072459012058 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 1072459012059 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 1072459012060 trimer interface [polypeptide binding]; other site 1072459012061 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 1072459012062 trimer interface [polypeptide binding]; other site 1072459012063 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 1072459012064 Haemagglutinin; Region: HIM; pfam05662 1072459012065 Haemagglutinin; Region: HIM; pfam05662 1072459012066 YadA-like C-terminal region; Region: YadA; pfam03895 1072459012067 L-lactate permease; Provisional; Region: PRK10420 1072459012068 glycolate transporter; Provisional; Region: PRK09695 1072459012069 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 1072459012070 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1072459012071 DNA-binding site [nucleotide binding]; DNA binding site 1072459012072 FCD domain; Region: FCD; pfam07729 1072459012073 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 1072459012074 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1072459012075 phosphate binding site [ion binding]; other site 1072459012076 putative rRNA methylase; Provisional; Region: PRK10358 1072459012077 serine acetyltransferase; Provisional; Region: cysE; PRK11132 1072459012078 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 1072459012079 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1072459012080 trimer interface [polypeptide binding]; other site 1072459012081 active site 1072459012082 substrate binding site [chemical binding]; other site 1072459012083 CoA binding site [chemical binding]; other site 1072459012084 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1072459012085 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1072459012086 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1072459012087 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 1072459012088 SecA binding site; other site 1072459012089 Preprotein binding site; other site 1072459012090 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 1072459012091 GSH binding site [chemical binding]; other site 1072459012092 catalytic residues [active] 1072459012093 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1072459012094 active site residue [active] 1072459012095 phosphoglyceromutase; Provisional; Region: PRK05434 1072459012096 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 1072459012097 AmiB activator; Provisional; Region: PRK11637 1072459012098 Peptidase family M23; Region: Peptidase_M23; pfam01551 1072459012099 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 1072459012100 NodB motif; other site 1072459012101 putative active site [active] 1072459012102 putative catalytic site [active] 1072459012103 Zn binding site [ion binding]; other site 1072459012104 putative glycosyl transferase; Provisional; Region: PRK10073 1072459012105 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1072459012106 active site 1072459012107 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 1072459012108 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1072459012109 NAD(P) binding site [chemical binding]; other site 1072459012110 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1072459012111 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1072459012112 substrate-cofactor binding pocket; other site 1072459012113 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1072459012114 catalytic residue [active] 1072459012115 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 1072459012116 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 1072459012117 NADP binding site [chemical binding]; other site 1072459012118 homopentamer interface [polypeptide binding]; other site 1072459012119 substrate binding site [chemical binding]; other site 1072459012120 active site 1072459012121 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1072459012122 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1072459012123 putative active site [active] 1072459012124 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1072459012125 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1072459012126 putative active site [active] 1072459012127 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1072459012128 O-Antigen ligase; Region: Wzy_C; pfam04932 1072459012129 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1072459012130 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1072459012131 active site 1072459012132 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 1072459012133 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1072459012134 Ligand binding site; other site 1072459012135 metal-binding site 1072459012136 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 1072459012137 Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; pfam06176 1072459012138 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 1072459012139 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1072459012140 Ligand binding site; other site 1072459012141 metal-binding site 1072459012142 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 1072459012143 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 1072459012144 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1072459012145 Ligand binding site; other site 1072459012146 metal-binding site 1072459012147 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 1072459012148 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 1072459012149 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1072459012150 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1072459012151 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 1072459012152 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1072459012153 putative active site [active] 1072459012154 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 1072459012155 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 1072459012156 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1072459012157 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1072459012158 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1072459012159 active site 1072459012160 (T/H)XGH motif; other site 1072459012161 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1072459012162 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1072459012163 DNA binding site [nucleotide binding] 1072459012164 catalytic residue [active] 1072459012165 H2TH interface [polypeptide binding]; other site 1072459012166 putative catalytic residues [active] 1072459012167 turnover-facilitating residue; other site 1072459012168 intercalation triad [nucleotide binding]; other site 1072459012169 8OG recognition residue [nucleotide binding]; other site 1072459012170 putative reading head residues; other site 1072459012171 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1072459012172 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1072459012173 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1072459012174 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1072459012175 hypothetical protein; Reviewed; Region: PRK00024 1072459012176 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1072459012177 MPN+ (JAMM) motif; other site 1072459012178 Zinc-binding site [ion binding]; other site 1072459012179 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1072459012180 Flavoprotein; Region: Flavoprotein; pfam02441 1072459012181 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1072459012182 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1072459012183 trimer interface [polypeptide binding]; other site 1072459012184 active site 1072459012185 division inhibitor protein; Provisional; Region: slmA; PRK09480 1072459012186 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1072459012187 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1072459012188 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 1072459012189 putative active site [active] 1072459012190 putative NTP binding site [chemical binding]; other site 1072459012191 putative nucleic acid binding site [nucleotide binding]; other site 1072459012192 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1072459012193 active site 1072459012194 ribonuclease PH; Reviewed; Region: rph; PRK00173 1072459012195 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1072459012196 hexamer interface [polypeptide binding]; other site 1072459012197 active site 1072459012198 hypothetical protein; Provisional; Region: PRK11820 1072459012199 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1072459012200 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1072459012201 DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525 1072459012202 BRO family, N-terminal domain; Region: Bro-N; pfam02498 1072459012203 Predicted membrane protein [Function unknown]; Region: COG2860 1072459012204 UPF0126 domain; Region: UPF0126; pfam03458 1072459012205 UPF0126 domain; Region: UPF0126; pfam03458 1072459012206 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 1072459012207 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 1072459012208 nucleotide binding pocket [chemical binding]; other site 1072459012209 K-X-D-G motif; other site 1072459012210 catalytic site [active] 1072459012211 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1072459012212 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1072459012213 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1072459012214 catalytic site [active] 1072459012215 G-X2-G-X-G-K; other site 1072459012216 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 1072459012217 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 1072459012218 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1072459012219 Zn2+ binding site [ion binding]; other site 1072459012220 Mg2+ binding site [ion binding]; other site 1072459012221 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1072459012222 synthetase active site [active] 1072459012223 NTP binding site [chemical binding]; other site 1072459012224 metal binding site [ion binding]; metal-binding site 1072459012225 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1072459012226 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1072459012227 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 1072459012228 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1072459012229 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 1072459012230 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1072459012231 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1072459012232 generic binding surface II; other site 1072459012233 ssDNA binding site; other site 1072459012234 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1072459012235 ATP binding site [chemical binding]; other site 1072459012236 putative Mg++ binding site [ion binding]; other site 1072459012237 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1072459012238 nucleotide binding region [chemical binding]; other site 1072459012239 ATP-binding site [chemical binding]; other site 1072459012240 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 1072459012241 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 1072459012242 AsmA family; Region: AsmA; pfam05170 1072459012243 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1072459012244 Protein of unknown function (DUF1498); Region: DUF1498; pfam07385 1072459012245 fructokinase; Reviewed; Region: PRK09557 1072459012246 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1072459012247 nucleotide binding site [chemical binding]; other site 1072459012248 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1072459012249 intersubunit interface [polypeptide binding]; other site 1072459012250 active site 1072459012251 zinc binding site [ion binding]; other site 1072459012252 Na+ binding site [ion binding]; other site 1072459012253 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1072459012254 intersubunit interface [polypeptide binding]; other site 1072459012255 active site 1072459012256 zinc binding site [ion binding]; other site 1072459012257 Na+ binding site [ion binding]; other site 1072459012258 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1072459012259 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1072459012260 active site 1072459012261 P-loop; other site 1072459012262 phosphorylation site [posttranslational modification] 1072459012263 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1072459012264 active site 1072459012265 phosphorylation site [posttranslational modification] 1072459012266 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1072459012267 HTH domain; Region: HTH_11; pfam08279 1072459012268 Mga helix-turn-helix domain; Region: Mga; pfam05043 1072459012269 PRD domain; Region: PRD; pfam00874 1072459012270 PRD domain; Region: PRD; pfam00874 1072459012271 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1072459012272 active site 1072459012273 P-loop; other site 1072459012274 phosphorylation site [posttranslational modification] 1072459012275 putative alpha-glucosidase; Provisional; Region: PRK10658 1072459012276 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1072459012277 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 1072459012278 active site 1072459012279 homotrimer interface [polypeptide binding]; other site 1072459012280 catalytic site [active] 1072459012281 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 1072459012282 putative transporter; Provisional; Region: PRK11462 1072459012283 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1072459012284 integrase; Provisional; Region: PRK09692 1072459012285 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1072459012286 active site 1072459012287 Int/Topo IB signature motif; other site 1072459012288 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1072459012289 TPR motif; other site 1072459012290 binding surface 1072459012291 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 1072459012292 Sulfatase; Region: Sulfatase; cl17466 1072459012293 putative transposase OrfB; Reviewed; Region: PHA02517 1072459012294 HTH-like domain; Region: HTH_21; pfam13276 1072459012295 Integrase core domain; Region: rve; pfam00665 1072459012296 Integrase core domain; Region: rve_3; pfam13683 1072459012297 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1072459012298 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1072459012299 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1072459012300 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1072459012301 homodimer interface [polypeptide binding]; other site 1072459012302 catalytic residue [active] 1072459012303 HTH-like domain; Region: HTH_21; pfam13276 1072459012304 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 1072459012305 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1072459012306 putative active site [active] 1072459012307 putative NTP binding site [chemical binding]; other site 1072459012308 putative nucleic acid binding site [nucleotide binding]; other site 1072459012309 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1072459012310 CE10_4238; putative transposase B, IS1203, fragment 1072459012311 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1072459012312 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1072459012313 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1072459012314 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1072459012315 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 1072459012316 Hexamer interface [polypeptide binding]; other site 1072459012317 Hexagonal pore residue; other site 1072459012318 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1072459012319 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 1072459012320 Hexamer interface [polypeptide binding]; other site 1072459012321 Hexagonal pore residue; other site 1072459012322 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1072459012323 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 1072459012324 Hexamer interface [polypeptide binding]; other site 1072459012325 Hexagonal pore residue; other site 1072459012326 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1072459012327 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1072459012328 putative catalytic cysteine [active] 1072459012329 Ethanolamine utilisation protein EutN/carboxysome; Region: EutN_CcmL; pfam03319 1072459012330 Hexamer/Pentamer interface [polypeptide binding]; other site 1072459012331 central pore; other site 1072459012332 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1072459012333 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 1072459012334 putative active site [active] 1072459012335 metal binding site [ion binding]; metal-binding site 1072459012336 Pyruvate formate lyase; Region: PFL; pfam02901 1072459012337 Pyruvate formate lyase; Region: PFL; pfam02901 1072459012338 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 1072459012339 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 1072459012340 dimer interface [polypeptide binding]; other site 1072459012341 active site 1072459012342 glycine loop; other site 1072459012343 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 1072459012344 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1072459012345 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1072459012346 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 1072459012347 Hexamer interface [polypeptide binding]; other site 1072459012348 Hexagonal pore residue; other site 1072459012349 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 1072459012350 Propanediol utilisation protein PduL; Region: PduL; pfam06130 1072459012351 Propanediol utilisation protein PduL; Region: PduL; pfam06130 1072459012352 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1072459012353 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1072459012354 CE10_4255; putative transposase B, IS3411, fragment 1072459012355 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 1072459012356 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1072459012357 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1072459012358 dimerization interface [polypeptide binding]; other site 1072459012359 substrate binding pocket [chemical binding]; other site 1072459012360 permease DsdX; Provisional; Region: PRK09921 1072459012361 gluconate transporter; Region: gntP; TIGR00791 1072459012362 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 1072459012363 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1072459012364 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1072459012365 catalytic residue [active] 1072459012366 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 1072459012367 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 1072459012368 putative kinase; Provisional; Region: PRK09954 1072459012369 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1072459012370 putative DNA binding site [nucleotide binding]; other site 1072459012371 putative Zn2+ binding site [ion binding]; other site 1072459012372 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 1072459012373 substrate binding site [chemical binding]; other site 1072459012374 ATP binding site [chemical binding]; other site 1072459012375 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1072459012376 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1072459012377 Nucleoside recognition; Region: Gate; pfam07670 1072459012378 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1072459012379 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 1072459012380 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 1072459012381 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1072459012382 substrate binding site [chemical binding]; other site 1072459012383 ATP binding site [chemical binding]; other site 1072459012384 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 1072459012385 putative trimer interface [polypeptide binding]; other site 1072459012386 putative active site [active] 1072459012387 putative substrate binding site [chemical binding]; other site 1072459012388 putative CoA binding site [chemical binding]; other site 1072459012389 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 1072459012390 Predicted GTPase [General function prediction only]; Region: COG3596 1072459012391 YfjP GTPase; Region: YfjP; cd11383 1072459012392 G1 box; other site 1072459012393 GTP/Mg2+ binding site [chemical binding]; other site 1072459012394 Switch I region; other site 1072459012395 G2 box; other site 1072459012396 Switch II region; other site 1072459012397 G3 box; other site 1072459012398 G4 box; other site 1072459012399 G5 box; other site 1072459012400 HTH domain; Region: HTH_11; cl17392 1072459012401 WYL domain; Region: WYL; pfam13280 1072459012402 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 1072459012403 Domain of unknown function (DUF932); Region: DUF932; pfam06067 1072459012404 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1072459012405 Transposase; Region: HTH_Tnp_1; cl17663 1072459012406 HTH-like domain; Region: HTH_21; pfam13276 1072459012407 Integrase core domain; Region: rve; pfam00665 1072459012408 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1072459012409 Integrase core domain; Region: rve_3; pfam13683 1072459012410 Antirestriction protein; Region: Antirestrict; pfam03230 1072459012411 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 1072459012412 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1072459012413 MPN+ (JAMM) motif; other site 1072459012414 Zinc-binding site [ion binding]; other site 1072459012415 Protein of unknown function (DUF987); Region: DUF987; pfam06174 1072459012416 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 1072459012417 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 1072459012418 Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117 1072459012419 Methyltransferase domain; Region: Methyltransf_27; pfam13708 1072459012420 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 1072459012421 sugar efflux transporter; Region: 2A0120; TIGR00899 1072459012422 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459012423 putative substrate translocation pore; other site 1072459012424 EamA-like transporter family; Region: EamA; pfam00892 1072459012425 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1072459012426 EamA-like transporter family; Region: EamA; pfam00892 1072459012427 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 1072459012428 lipoprotein, YaeC family; Region: TIGR00363 1072459012429 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 1072459012430 Tetratricopeptide repeat; Region: TPR_3; pfam07720 1072459012431 Tetratricopeptide repeat; Region: TPR_3; pfam07720 1072459012432 pathogenicity island 1 effector protein SipB; Provisional; Region: PRK15374 1072459012433 Invasion plasmid antigen IpaD; Region: IpaD; cl05827 1072459012434 invasion protein regulator; Provisional; Region: PRK12370 1072459012435 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1072459012436 DNA binding site [nucleotide binding] 1072459012437 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1072459012438 TPR motif; other site 1072459012439 binding surface 1072459012440 potential frameshift: common BLAST hit: gi|218702502|ref|YP_002410131.1| putative invasin/intimin protein 1072459012441 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 1072459012442 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 1072459012443 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1072459012444 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1072459012445 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1072459012446 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1072459012447 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1072459012448 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 1072459012449 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 1072459012450 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459012451 putative substrate translocation pore; other site 1072459012452 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 1072459012453 Predicted transcriptional regulator [Transcription]; Region: COG2944 1072459012454 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1072459012455 non-specific DNA binding site [nucleotide binding]; other site 1072459012456 salt bridge; other site 1072459012457 sequence-specific DNA binding site [nucleotide binding]; other site 1072459012458 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 1072459012459 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1072459012460 cryptic adenine deaminase; Provisional; Region: PRK10027 1072459012461 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1072459012462 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1072459012463 active site 1072459012464 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 1072459012465 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 1072459012466 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459012467 putative substrate translocation pore; other site 1072459012468 regulatory protein UhpC; Provisional; Region: PRK11663 1072459012469 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459012470 putative substrate translocation pore; other site 1072459012471 sensory histidine kinase UhpB; Provisional; Region: PRK11644 1072459012472 MASE1; Region: MASE1; pfam05231 1072459012473 Histidine kinase; Region: HisKA_3; pfam07730 1072459012474 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 1072459012475 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1072459012476 active site 1072459012477 phosphorylation site [posttranslational modification] 1072459012478 intermolecular recognition site; other site 1072459012479 dimerization interface [polypeptide binding]; other site 1072459012480 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1072459012481 DNA binding residues [nucleotide binding] 1072459012482 dimerization interface [polypeptide binding]; other site 1072459012483 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 1072459012484 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1072459012485 putative valine binding site [chemical binding]; other site 1072459012486 dimer interface [polypeptide binding]; other site 1072459012487 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 1072459012488 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1072459012489 PYR/PP interface [polypeptide binding]; other site 1072459012490 dimer interface [polypeptide binding]; other site 1072459012491 TPP binding site [chemical binding]; other site 1072459012492 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1072459012493 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1072459012494 TPP-binding site [chemical binding]; other site 1072459012495 dimer interface [polypeptide binding]; other site 1072459012496 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 1072459012497 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459012498 putative substrate translocation pore; other site 1072459012499 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 1072459012500 Domain of unknown function (DUF202); Region: DUF202; pfam02656 1072459012501 Predicted membrane protein [Function unknown]; Region: COG2149 1072459012502 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1072459012503 Sulfatase; Region: Sulfatase; pfam00884 1072459012504 putative transporter; Provisional; Region: PRK10484 1072459012505 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 1072459012506 Na binding site [ion binding]; other site 1072459012507 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1072459012508 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1072459012509 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1072459012510 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1072459012511 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1072459012512 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 1072459012513 NAD binding site [chemical binding]; other site 1072459012514 sugar binding site [chemical binding]; other site 1072459012515 divalent metal binding site [ion binding]; other site 1072459012516 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1072459012517 dimer interface [polypeptide binding]; other site 1072459012518 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 1072459012519 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 1072459012520 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1072459012521 active site turn [active] 1072459012522 phosphorylation site [posttranslational modification] 1072459012523 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1072459012524 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1072459012525 DNA-binding site [nucleotide binding]; DNA binding site 1072459012526 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1072459012527 putative transporter; Validated; Region: PRK03818 1072459012528 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1072459012529 TrkA-C domain; Region: TrkA_C; pfam02080 1072459012530 TrkA-C domain; Region: TrkA_C; pfam02080 1072459012531 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 1072459012532 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1072459012533 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1072459012534 putative dimer interface [polypeptide binding]; other site 1072459012535 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1072459012536 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1072459012537 putative dimer interface [polypeptide binding]; other site 1072459012538 hypothetical protein; Provisional; Region: PRK11616 1072459012539 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 1072459012540 putative oxidoreductase; Provisional; Region: PRK11445 1072459012541 hypothetical protein; Provisional; Region: PRK07236 1072459012542 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459012543 D-galactonate transporter; Region: 2A0114; TIGR00893 1072459012544 putative substrate translocation pore; other site 1072459012545 galactonate dehydratase; Provisional; Region: PRK14017 1072459012546 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 1072459012547 putative active site pocket [active] 1072459012548 putative metal binding site [ion binding]; other site 1072459012549 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 1072459012550 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1072459012551 active site 1072459012552 intersubunit interface [polypeptide binding]; other site 1072459012553 catalytic residue [active] 1072459012554 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 1072459012555 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 1072459012556 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1072459012557 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1072459012558 DNA-binding site [nucleotide binding]; DNA binding site 1072459012559 FCD domain; Region: FCD; pfam07729 1072459012560 hypothetical protein; Provisional; Region: PRK10215 1072459012561 sugar phosphate phosphatase; Provisional; Region: PRK10513 1072459012562 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1072459012563 active site 1072459012564 motif I; other site 1072459012565 motif II; other site 1072459012566 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1072459012567 hypothetical protein; Provisional; Region: PRK11426 1072459012568 HTH-like domain; Region: HTH_21; pfam13276 1072459012569 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1072459012570 Integrase core domain; Region: rve; pfam00665 1072459012571 Integrase core domain; Region: rve_2; pfam13333 1072459012572 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1072459012573 Helix-turn-helix domain; Region: HTH_28; pfam13518 1072459012574 Helix-turn-helix domain; Region: HTH_28; pfam13518 1072459012575 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 1072459012576 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1072459012577 Mg2+ binding site [ion binding]; other site 1072459012578 G-X-G motif; other site 1072459012579 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1072459012580 anchoring element; other site 1072459012581 dimer interface [polypeptide binding]; other site 1072459012582 ATP binding site [chemical binding]; other site 1072459012583 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1072459012584 active site 1072459012585 putative metal-binding site [ion binding]; other site 1072459012586 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1072459012587 recF protein; Region: recf; TIGR00611 1072459012588 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1072459012589 Walker A/P-loop; other site 1072459012590 ATP binding site [chemical binding]; other site 1072459012591 Q-loop/lid; other site 1072459012592 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1072459012593 ABC transporter signature motif; other site 1072459012594 Walker B; other site 1072459012595 D-loop; other site 1072459012596 H-loop/switch region; other site 1072459012597 DNA polymerase III subunit beta; Validated; Region: PRK05643 1072459012598 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1072459012599 putative DNA binding surface [nucleotide binding]; other site 1072459012600 dimer interface [polypeptide binding]; other site 1072459012601 beta-clamp/clamp loader binding surface; other site 1072459012602 beta-clamp/translesion DNA polymerase binding surface; other site 1072459012603 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1072459012604 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1072459012605 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1072459012606 Walker A motif; other site 1072459012607 ATP binding site [chemical binding]; other site 1072459012608 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1072459012609 Walker B motif; other site 1072459012610 arginine finger; other site 1072459012611 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1072459012612 DnaA box-binding interface [nucleotide binding]; other site 1072459012613 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 1072459012614 ribonuclease P; Reviewed; Region: rnpA; PRK01732 1072459012615 membrane protein insertase; Provisional; Region: PRK01318 1072459012616 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1072459012617 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1072459012618 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1072459012619 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1072459012620 G1 box; other site 1072459012621 GTP/Mg2+ binding site [chemical binding]; other site 1072459012622 Switch I region; other site 1072459012623 G2 box; other site 1072459012624 Switch II region; other site 1072459012625 G3 box; other site 1072459012626 G4 box; other site 1072459012627 G5 box; other site 1072459012628 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1072459012629 tryptophanase, leader peptide-associated; Region: tnaA_trp_ase; TIGR02617 1072459012630 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1072459012631 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1072459012632 catalytic residue [active] 1072459012633 tryptophan permease TnaB; Provisional; Region: PRK09664 1072459012634 aromatic amino acid transport protein; Region: araaP; TIGR00837 1072459012635 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 1072459012636 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459012637 putative substrate translocation pore; other site 1072459012638 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 1072459012639 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1072459012640 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1072459012641 substrate binding pocket [chemical binding]; other site 1072459012642 dimerization interface [polypeptide binding]; other site 1072459012643 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1072459012644 Predicted flavoprotein [General function prediction only]; Region: COG0431 1072459012645 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1072459012646 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1072459012647 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 1072459012648 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1072459012649 active site 1072459012650 motif I; other site 1072459012651 motif II; other site 1072459012652 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1072459012653 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1072459012654 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 1072459012655 transcriptional regulator PhoU; Provisional; Region: PRK11115 1072459012656 PhoU domain; Region: PhoU; pfam01895 1072459012657 PhoU domain; Region: PhoU; pfam01895 1072459012658 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 1072459012659 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1072459012660 Walker A/P-loop; other site 1072459012661 ATP binding site [chemical binding]; other site 1072459012662 Q-loop/lid; other site 1072459012663 ABC transporter signature motif; other site 1072459012664 Walker B; other site 1072459012665 D-loop; other site 1072459012666 H-loop/switch region; other site 1072459012667 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 1072459012668 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1072459012669 dimer interface [polypeptide binding]; other site 1072459012670 conserved gate region; other site 1072459012671 putative PBP binding loops; other site 1072459012672 ABC-ATPase subunit interface; other site 1072459012673 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 1072459012674 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1072459012675 dimer interface [polypeptide binding]; other site 1072459012676 conserved gate region; other site 1072459012677 putative PBP binding loops; other site 1072459012678 ABC-ATPase subunit interface; other site 1072459012679 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1072459012680 Fimbrial protein; Region: Fimbrial; cl01416 1072459012681 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1072459012682 PapC N-terminal domain; Region: PapC_N; pfam13954 1072459012683 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1072459012684 PapC C-terminal domain; Region: PapC_C; pfam13953 1072459012685 fimbrial chaperone protein; Provisional; Region: lfpB; PRK15290 1072459012686 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1072459012687 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1072459012688 fimbrial protein; Provisional; Region: lpfA; PRK15289 1072459012689 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1072459012690 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1072459012691 glutaminase active site [active] 1072459012692 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1072459012693 dimer interface [polypeptide binding]; other site 1072459012694 active site 1072459012695 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1072459012696 dimer interface [polypeptide binding]; other site 1072459012697 active site 1072459012698 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 1072459012699 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1072459012700 Substrate binding site; other site 1072459012701 Mg++ binding site; other site 1072459012702 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1072459012703 active site 1072459012704 substrate binding site [chemical binding]; other site 1072459012705 CoA binding site [chemical binding]; other site 1072459012706 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1072459012707 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1072459012708 gamma subunit interface [polypeptide binding]; other site 1072459012709 epsilon subunit interface [polypeptide binding]; other site 1072459012710 LBP interface [polypeptide binding]; other site 1072459012711 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1072459012712 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1072459012713 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1072459012714 alpha subunit interaction interface [polypeptide binding]; other site 1072459012715 Walker A motif; other site 1072459012716 ATP binding site [chemical binding]; other site 1072459012717 Walker B motif; other site 1072459012718 inhibitor binding site; inhibition site 1072459012719 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1072459012720 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1072459012721 core domain interface [polypeptide binding]; other site 1072459012722 delta subunit interface [polypeptide binding]; other site 1072459012723 epsilon subunit interface [polypeptide binding]; other site 1072459012724 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1072459012725 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1072459012726 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1072459012727 beta subunit interaction interface [polypeptide binding]; other site 1072459012728 Walker A motif; other site 1072459012729 ATP binding site [chemical binding]; other site 1072459012730 Walker B motif; other site 1072459012731 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1072459012732 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1072459012733 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1072459012734 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1072459012735 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1072459012736 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1072459012737 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1072459012738 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1072459012739 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 1072459012740 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1072459012741 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1072459012742 S-adenosylmethionine binding site [chemical binding]; other site 1072459012743 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1072459012744 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1072459012745 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1072459012746 FMN-binding protein MioC; Provisional; Region: PRK09004 1072459012747 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 1072459012748 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1072459012749 putative DNA binding site [nucleotide binding]; other site 1072459012750 putative Zn2+ binding site [ion binding]; other site 1072459012751 AsnC family; Region: AsnC_trans_reg; pfam01037 1072459012752 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 1072459012753 dimer interface [polypeptide binding]; other site 1072459012754 active site 1072459012755 hypothetical protein; Provisional; Region: yieM; PRK10997 1072459012756 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 1072459012757 metal ion-dependent adhesion site (MIDAS); other site 1072459012758 regulatory ATPase RavA; Provisional; Region: PRK13531 1072459012759 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1072459012760 Walker A motif; other site 1072459012761 ATP binding site [chemical binding]; other site 1072459012762 Walker B motif; other site 1072459012763 arginine finger; other site 1072459012764 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 1072459012765 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 1072459012766 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1072459012767 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1072459012768 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 1072459012769 potassium uptake protein; Region: kup; TIGR00794 1072459012770 D-ribose pyranase; Provisional; Region: PRK11797 1072459012771 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 1072459012772 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1072459012773 Walker A/P-loop; other site 1072459012774 ATP binding site [chemical binding]; other site 1072459012775 Q-loop/lid; other site 1072459012776 ABC transporter signature motif; other site 1072459012777 Walker B; other site 1072459012778 D-loop; other site 1072459012779 H-loop/switch region; other site 1072459012780 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1072459012781 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1072459012782 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1072459012783 TM-ABC transporter signature motif; other site 1072459012784 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 1072459012785 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1072459012786 ligand binding site [chemical binding]; other site 1072459012787 dimerization interface [polypeptide binding]; other site 1072459012788 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1072459012789 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1072459012790 substrate binding site [chemical binding]; other site 1072459012791 dimer interface [polypeptide binding]; other site 1072459012792 ATP binding site [chemical binding]; other site 1072459012793 transcriptional repressor RbsR; Provisional; Region: PRK10423 1072459012794 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1072459012795 DNA binding site [nucleotide binding] 1072459012796 domain linker motif; other site 1072459012797 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 1072459012798 dimerization interface [polypeptide binding]; other site 1072459012799 ligand binding site [chemical binding]; other site 1072459012800 putative transporter; Provisional; Region: PRK10504 1072459012801 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459012802 putative substrate translocation pore; other site 1072459012803 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459012804 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1072459012805 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1072459012806 DNA-binding site [nucleotide binding]; DNA binding site 1072459012807 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1072459012808 transcriptional regulator HdfR; Provisional; Region: PRK03601 1072459012809 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1072459012810 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1072459012811 dimerization interface [polypeptide binding]; other site 1072459012812 hypothetical protein; Provisional; Region: PRK11027 1072459012813 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1072459012814 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1072459012815 Walker A motif; other site 1072459012816 ATP binding site [chemical binding]; other site 1072459012817 Walker B motif; other site 1072459012818 arginine finger; other site 1072459012819 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1072459012820 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 1072459012821 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1072459012822 PYR/PP interface [polypeptide binding]; other site 1072459012823 dimer interface [polypeptide binding]; other site 1072459012824 TPP binding site [chemical binding]; other site 1072459012825 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1072459012826 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1072459012827 TPP-binding site [chemical binding]; other site 1072459012828 dimer interface [polypeptide binding]; other site 1072459012829 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 1072459012830 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1072459012831 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1072459012832 homodimer interface [polypeptide binding]; other site 1072459012833 substrate-cofactor binding pocket; other site 1072459012834 catalytic residue [active] 1072459012835 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1072459012836 threonine dehydratase; Reviewed; Region: PRK09224 1072459012837 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1072459012838 tetramer interface [polypeptide binding]; other site 1072459012839 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1072459012840 catalytic residue [active] 1072459012841 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 1072459012842 putative Ile/Val binding site [chemical binding]; other site 1072459012843 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1072459012844 putative Ile/Val binding site [chemical binding]; other site 1072459012845 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1072459012846 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 1072459012847 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 1072459012848 putative dimerization interface [polypeptide binding]; other site 1072459012849 ketol-acid reductoisomerase; Validated; Region: PRK05225 1072459012850 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1072459012851 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1072459012852 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1072459012853 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 1072459012854 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 1072459012855 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3692 1072459012856 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 1072459012857 Part of AAA domain; Region: AAA_19; pfam13245 1072459012858 Family description; Region: UvrD_C_2; pfam13538 1072459012859 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 1072459012860 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1072459012861 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 1072459012862 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1072459012863 ATP binding site [chemical binding]; other site 1072459012864 Mg++ binding site [ion binding]; other site 1072459012865 motif III; other site 1072459012866 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1072459012867 nucleotide binding region [chemical binding]; other site 1072459012868 ATP-binding site [chemical binding]; other site 1072459012869 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1072459012870 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1072459012871 catalytic residues [active] 1072459012872 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1072459012873 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1072459012874 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1072459012875 RNA binding site [nucleotide binding]; other site 1072459012876 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1072459012877 multimer interface [polypeptide binding]; other site 1072459012878 Walker A motif; other site 1072459012879 ATP binding site [chemical binding]; other site 1072459012880 Walker B motif; other site 1072459012881 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 1072459012882 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1072459012883 Mg++ binding site [ion binding]; other site 1072459012884 putative catalytic motif [active] 1072459012885 substrate binding site [chemical binding]; other site 1072459012886 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 1072459012887 Chain length determinant protein; Region: Wzz; pfam02706 1072459012888 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 1072459012889 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1072459012890 active site 1072459012891 homodimer interface [polypeptide binding]; other site 1072459012892 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 1072459012893 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1072459012894 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1072459012895 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1072459012896 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 1072459012897 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1072459012898 NAD binding site [chemical binding]; other site 1072459012899 substrate binding site [chemical binding]; other site 1072459012900 homodimer interface [polypeptide binding]; other site 1072459012901 active site 1072459012902 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1072459012903 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1072459012904 substrate binding site; other site 1072459012905 tetramer interface; other site 1072459012906 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 1072459012907 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1072459012908 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1072459012909 inhibitor-cofactor binding pocket; inhibition site 1072459012910 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1072459012911 catalytic residue [active] 1072459012912 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1072459012913 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 1072459012914 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 1072459012915 putative common antigen polymerase; Provisional; Region: PRK02975 1072459012916 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1072459012917 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1072459012918 putative transport protein YifK; Provisional; Region: PRK10746 1072459012919 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 1072459012920 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1072459012921 FeS/SAM binding site; other site 1072459012922 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1072459012923 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1072459012924 Sulfatase; Region: Sulfatase; pfam00884 1072459012925 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 1072459012926 HemY protein N-terminus; Region: HemY_N; pfam07219 1072459012927 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 1072459012928 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 1072459012929 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 1072459012930 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1072459012931 active site 1072459012932 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1072459012933 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1072459012934 domain interfaces; other site 1072459012935 active site 1072459012936 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 1072459012937 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 1072459012938 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 1072459012939 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 1072459012940 putative iron binding site [ion binding]; other site 1072459012941 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 1072459012942 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 1072459012943 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1072459012944 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1072459012945 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1072459012946 hypothetical protein; Provisional; Region: PRK10963 1072459012947 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 1072459012948 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1072459012949 active site 1072459012950 DNA binding site [nucleotide binding] 1072459012951 Int/Topo IB signature motif; other site 1072459012952 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 1072459012953 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1072459012954 motif II; other site 1072459012955 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 1072459012956 Part of AAA domain; Region: AAA_19; pfam13245 1072459012957 Family description; Region: UvrD_C_2; pfam13538 1072459012958 Uncharacterized conserved protein [Function unknown]; Region: COG1912 1072459012959 Predicted periplasmic protein [Function unknown]; Region: COG3698 1072459012960 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1072459012961 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1072459012962 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 1072459012963 Cl binding site [ion binding]; other site 1072459012964 oligomer interface [polypeptide binding]; other site 1072459012965 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 1072459012966 Protein of unknown function (DUF3289); Region: DUF3289; cl11840 1072459012967 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 1072459012968 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 1072459012969 EamA-like transporter family; Region: EamA; cl17759 1072459012970 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1072459012971 CoenzymeA binding site [chemical binding]; other site 1072459012972 subunit interaction site [polypeptide binding]; other site 1072459012973 PHB binding site; other site 1072459012974 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 1072459012975 dimerization interface [polypeptide binding]; other site 1072459012976 substrate binding site [chemical binding]; other site 1072459012977 active site 1072459012978 calcium binding site [ion binding]; other site 1072459012979 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 1072459012980 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1072459012981 ATP binding site [chemical binding]; other site 1072459012982 putative Mg++ binding site [ion binding]; other site 1072459012983 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1072459012984 nucleotide binding region [chemical binding]; other site 1072459012985 ATP-binding site [chemical binding]; other site 1072459012986 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1072459012987 Helicase and RNase D C-terminal; Region: HRDC; smart00341 1072459012988 threonine efflux system; Provisional; Region: PRK10229 1072459012989 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 1072459012990 lysophospholipase L2; Provisional; Region: PRK10749 1072459012991 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1072459012992 putative hydrolase; Provisional; Region: PRK10976 1072459012993 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1072459012994 active site 1072459012995 motif I; other site 1072459012996 motif II; other site 1072459012997 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1072459012998 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1072459012999 EamA-like transporter family; Region: EamA; pfam00892 1072459013000 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1072459013001 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1072459013002 THF binding site; other site 1072459013003 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1072459013004 substrate binding site [chemical binding]; other site 1072459013005 THF binding site; other site 1072459013006 zinc-binding site [ion binding]; other site 1072459013007 Transposase; Region: HTH_Tnp_1; cl17663 1072459013008 IS2 transposase TnpB; Reviewed; Region: PRK09409 1072459013009 HTH-like domain; Region: HTH_21; pfam13276 1072459013010 Integrase core domain; Region: rve; pfam00665 1072459013011 Integrase core domain; Region: rve_3; pfam13683 1072459013012 putative transposase OrfB; Reviewed; Region: PHA02517 1072459013013 HTH-like domain; Region: HTH_21; pfam13276 1072459013014 Integrase core domain; Region: rve; pfam00665 1072459013015 Integrase core domain; Region: rve_3; pfam13683 1072459013016 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1072459013017 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1072459013018 uridine phosphorylase; Provisional; Region: PRK11178 1072459013019 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 1072459013020 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 1072459013021 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1072459013022 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1072459013023 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 1072459013024 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 1072459013025 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1072459013026 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1072459013027 Bacterial transcriptional regulator; Region: IclR; pfam01614 1072459013028 DNA recombination protein RmuC; Provisional; Region: PRK10361 1072459013029 RmuC family; Region: RmuC; pfam02646 1072459013030 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1072459013031 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1072459013032 S-adenosylmethionine binding site [chemical binding]; other site 1072459013033 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 1072459013034 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1072459013035 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 1072459013036 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1072459013037 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 1072459013038 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 1072459013039 sec-independent translocase; Provisional; Region: PRK01770 1072459013040 sec-independent translocase; Provisional; Region: tatB; PRK00404 1072459013041 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 1072459013042 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1072459013043 active site 1072459013044 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 1072459013045 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 1072459013046 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 1072459013047 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 1072459013048 FMN reductase; Validated; Region: fre; PRK08051 1072459013049 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 1072459013050 FAD binding pocket [chemical binding]; other site 1072459013051 FAD binding motif [chemical binding]; other site 1072459013052 phosphate binding motif [ion binding]; other site 1072459013053 beta-alpha-beta structure motif; other site 1072459013054 NAD binding pocket [chemical binding]; other site 1072459013055 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 1072459013056 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1072459013057 dimer interface [polypeptide binding]; other site 1072459013058 active site 1072459013059 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 1072459013060 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1072459013061 substrate binding site [chemical binding]; other site 1072459013062 oxyanion hole (OAH) forming residues; other site 1072459013063 trimer interface [polypeptide binding]; other site 1072459013064 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1072459013065 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1072459013066 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1072459013067 proline dipeptidase; Provisional; Region: PRK13607 1072459013068 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1072459013069 active site 1072459013070 hypothetical protein; Provisional; Region: PRK11568 1072459013071 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1072459013072 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1072459013073 potassium transporter; Provisional; Region: PRK10750 1072459013074 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1072459013075 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 1072459013076 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 1072459013077 Walker A motif; other site 1072459013078 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1072459013079 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1072459013080 GTP binding site; other site 1072459013081 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 1072459013082 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1072459013083 serine/threonine protein kinase; Provisional; Region: PRK11768 1072459013084 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 1072459013085 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1072459013086 catalytic residues [active] 1072459013087 hinge region; other site 1072459013088 alpha helical domain; other site 1072459013089 hypothetical protein; Provisional; Region: PRK11367 1072459013090 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 1072459013091 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1072459013092 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 1072459013093 putative acyl-acceptor binding pocket; other site 1072459013094 DNA polymerase I; Provisional; Region: PRK05755 1072459013095 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1072459013096 active site 1072459013097 metal binding site 1 [ion binding]; metal-binding site 1072459013098 putative 5' ssDNA interaction site; other site 1072459013099 metal binding site 3; metal-binding site 1072459013100 metal binding site 2 [ion binding]; metal-binding site 1072459013101 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1072459013102 putative DNA binding site [nucleotide binding]; other site 1072459013103 putative metal binding site [ion binding]; other site 1072459013104 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 1072459013105 active site 1072459013106 catalytic site [active] 1072459013107 substrate binding site [chemical binding]; other site 1072459013108 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1072459013109 active site 1072459013110 DNA binding site [nucleotide binding] 1072459013111 catalytic site [active] 1072459013112 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1072459013113 G1 box; other site 1072459013114 GTP/Mg2+ binding site [chemical binding]; other site 1072459013115 Switch I region; other site 1072459013116 G2 box; other site 1072459013117 G3 box; other site 1072459013118 Switch II region; other site 1072459013119 G4 box; other site 1072459013120 G5 box; other site 1072459013121 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078 1072459013122 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 1072459013123 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1072459013124 FeS/SAM binding site; other site 1072459013125 HemN C-terminal domain; Region: HemN_C; pfam06969 1072459013126 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 1072459013127 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1072459013128 active site 1072459013129 phosphorylation site [posttranslational modification] 1072459013130 intermolecular recognition site; other site 1072459013131 dimerization interface [polypeptide binding]; other site 1072459013132 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1072459013133 Walker A motif; other site 1072459013134 ATP binding site [chemical binding]; other site 1072459013135 Walker B motif; other site 1072459013136 arginine finger; other site 1072459013137 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1072459013138 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 1072459013139 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1072459013140 putative active site [active] 1072459013141 heme pocket [chemical binding]; other site 1072459013142 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1072459013143 dimer interface [polypeptide binding]; other site 1072459013144 phosphorylation site [posttranslational modification] 1072459013145 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1072459013146 ATP binding site [chemical binding]; other site 1072459013147 Mg2+ binding site [ion binding]; other site 1072459013148 G-X-G motif; other site 1072459013149 glutamine synthetase; Provisional; Region: glnA; PRK09469 1072459013150 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1072459013151 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1072459013152 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1072459013153 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1072459013154 G1 box; other site 1072459013155 putative GEF interaction site [polypeptide binding]; other site 1072459013156 GTP/Mg2+ binding site [chemical binding]; other site 1072459013157 Switch I region; other site 1072459013158 G2 box; other site 1072459013159 G3 box; other site 1072459013160 Switch II region; other site 1072459013161 G4 box; other site 1072459013162 G5 box; other site 1072459013163 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1072459013164 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1072459013165 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 1072459013166 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1072459013167 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1072459013168 transcriptional regulator protein; Region: phnR; TIGR03337 1072459013169 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1072459013170 DNA-binding site [nucleotide binding]; DNA binding site 1072459013171 UTRA domain; Region: UTRA; pfam07702 1072459013172 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1072459013173 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459013174 putative substrate translocation pore; other site 1072459013175 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 1072459013176 outer membrane porin L; Provisional; Region: ompL; PRK09980 1072459013177 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1072459013178 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459013179 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1072459013180 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1072459013181 alpha-glucosidase; Provisional; Region: PRK10426 1072459013182 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1072459013183 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 1072459013184 putative active site [active] 1072459013185 putative catalytic site [active] 1072459013186 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 1072459013187 active site 1072459013188 catalytic residues [active] 1072459013189 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 1072459013190 dimerization interface [polypeptide binding]; other site 1072459013191 putative active cleft [active] 1072459013192 Tagatose-1,6-bisphosphate aldolase [Carbohydrate transport and metabolism]; Region: LacD; COG3684 1072459013193 catalytic residue [active] 1072459013194 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 1072459013195 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1072459013196 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1072459013197 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 1072459013198 substrate binding site [chemical binding]; other site 1072459013199 ATP binding site [chemical binding]; other site 1072459013200 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1072459013201 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1072459013202 putative DNA binding site [nucleotide binding]; other site 1072459013203 putative Zn2+ binding site [ion binding]; other site 1072459013204 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1072459013205 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1072459013206 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1072459013207 motif II; other site 1072459013208 hypothetical protein; Reviewed; Region: PRK01637 1072459013209 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1072459013210 putative active site [active] 1072459013211 dimerization interface [polypeptide binding]; other site 1072459013212 putative tRNAtyr binding site [nucleotide binding]; other site 1072459013213 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1072459013214 Coenzyme A binding pocket [chemical binding]; other site 1072459013215 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 1072459013216 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1072459013217 LexA regulated protein; Provisional; Region: PRK11675 1072459013218 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 1072459013219 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 1072459013220 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 1072459013221 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 1072459013222 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 1072459013223 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 1072459013224 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 1072459013225 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 1072459013226 [4Fe-4S] binding site [ion binding]; other site 1072459013227 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1072459013228 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 1072459013229 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1072459013230 molybdopterin cofactor binding site; other site 1072459013231 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1072459013232 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 1072459013233 putative frv operon regulatory protein; Provisional; Region: PRK09863 1072459013234 HTH domain; Region: HTH_11; pfam08279 1072459013235 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1072459013236 active site 1072459013237 phosphorylation site [posttranslational modification] 1072459013238 putative peptidase; Provisional; Region: PRK09864 1072459013239 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1072459013240 oligomer interface [polypeptide binding]; other site 1072459013241 active site 1072459013242 metal binding site [ion binding]; metal-binding site 1072459013243 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 1072459013244 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1072459013245 active site 1072459013246 P-loop; other site 1072459013247 phosphorylation site [posttranslational modification] 1072459013248 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1072459013249 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1072459013250 active site 1072459013251 phosphorylation site [posttranslational modification] 1072459013252 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 1072459013253 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1072459013254 intersubunit interface [polypeptide binding]; other site 1072459013255 active site 1072459013256 Zn2+ binding site [ion binding]; other site 1072459013257 L-rhamnose isomerase; Provisional; Region: PRK01076 1072459013258 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 1072459013259 N- and C-terminal domain interface [polypeptide binding]; other site 1072459013260 active site 1072459013261 putative catalytic site [active] 1072459013262 metal binding site [ion binding]; metal-binding site 1072459013263 ATP binding site [chemical binding]; other site 1072459013264 rhamnulokinase; Provisional; Region: rhaB; PRK10640 1072459013265 carbohydrate binding site [chemical binding]; other site 1072459013266 transcriptional activator RhaS; Provisional; Region: PRK13503 1072459013267 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1072459013268 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1072459013269 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1072459013270 transcriptional activator RhaR; Provisional; Region: PRK13500 1072459013271 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1072459013272 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1072459013273 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1072459013274 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 1072459013275 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 1072459013276 superoxide dismutase; Provisional; Region: PRK10925 1072459013277 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1072459013278 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1072459013279 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 1072459013280 2-keto-3-deoxygluconate transporter; Region: kdgT; TIGR00793 1072459013281 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 1072459013282 MOSC domain; Region: MOSC; pfam03473 1072459013283 3-alpha domain; Region: 3-alpha; pfam03475 1072459013284 two-component sensor protein; Provisional; Region: cpxA; PRK09470 1072459013285 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1072459013286 dimerization interface [polypeptide binding]; other site 1072459013287 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1072459013288 dimer interface [polypeptide binding]; other site 1072459013289 phosphorylation site [posttranslational modification] 1072459013290 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1072459013291 ATP binding site [chemical binding]; other site 1072459013292 Mg2+ binding site [ion binding]; other site 1072459013293 G-X-G motif; other site 1072459013294 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 1072459013295 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1072459013296 active site 1072459013297 intermolecular recognition site; other site 1072459013298 dimerization interface [polypeptide binding]; other site 1072459013299 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1072459013300 DNA binding site [nucleotide binding] 1072459013301 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1072459013302 dimer interface [polypeptide binding]; other site 1072459013303 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 1072459013304 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1072459013305 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 1072459013306 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1072459013307 active site 1072459013308 ADP/pyrophosphate binding site [chemical binding]; other site 1072459013309 dimerization interface [polypeptide binding]; other site 1072459013310 allosteric effector site; other site 1072459013311 fructose-1,6-bisphosphate binding site; other site 1072459013312 sulfate transporter subunit; Provisional; Region: PRK10752 1072459013313 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1072459013314 CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672 1072459013315 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1072459013316 triosephosphate isomerase; Provisional; Region: PRK14567 1072459013317 substrate binding site [chemical binding]; other site 1072459013318 dimer interface [polypeptide binding]; other site 1072459013319 catalytic triad [active] 1072459013320 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 1072459013321 Predicted membrane protein [Function unknown]; Region: COG3152 1072459013322 hypothetical protein; Provisional; Region: PRK09981 1072459013323 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1072459013324 Ligand Binding Site [chemical binding]; other site 1072459013325 ferredoxin-NADP reductase; Provisional; Region: PRK10926 1072459013326 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1072459013327 FAD binding pocket [chemical binding]; other site 1072459013328 FAD binding motif [chemical binding]; other site 1072459013329 phosphate binding motif [ion binding]; other site 1072459013330 beta-alpha-beta structure motif; other site 1072459013331 NAD binding pocket [chemical binding]; other site 1072459013332 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1072459013333 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1072459013334 putative active site [active] 1072459013335 glycerol kinase; Provisional; Region: glpK; PRK00047 1072459013336 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1072459013337 N- and C-terminal domain interface [polypeptide binding]; other site 1072459013338 active site 1072459013339 MgATP binding site [chemical binding]; other site 1072459013340 catalytic site [active] 1072459013341 metal binding site [ion binding]; metal-binding site 1072459013342 glycerol binding site [chemical binding]; other site 1072459013343 homotetramer interface [polypeptide binding]; other site 1072459013344 homodimer interface [polypeptide binding]; other site 1072459013345 FBP binding site [chemical binding]; other site 1072459013346 protein IIAGlc interface [polypeptide binding]; other site 1072459013347 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1072459013348 amphipathic channel; other site 1072459013349 Asn-Pro-Ala signature motifs; other site 1072459013350 septal ring assembly protein ZapB; Provisional; Region: PRK15422 1072459013351 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1072459013352 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 1072459013353 UbiA prenyltransferase family; Region: UbiA; pfam01040 1072459013354 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1072459013355 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1072459013356 Walker A motif; other site 1072459013357 ATP binding site [chemical binding]; other site 1072459013358 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1072459013359 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1072459013360 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1072459013361 active site 1072459013362 HslU subunit interaction site [polypeptide binding]; other site 1072459013363 essential cell division protein FtsN; Provisional; Region: PRK10927 1072459013364 cell division protein FtsN; Provisional; Region: PRK12757 1072459013365 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1072459013366 DNA binding site [nucleotide binding] 1072459013367 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 1072459013368 domain linker motif; other site 1072459013369 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 1072459013370 dimerization interface [polypeptide binding]; other site 1072459013371 ligand binding site [chemical binding]; other site 1072459013372 primosome assembly protein PriA; Validated; Region: PRK05580 1072459013373 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1072459013374 ATP binding site [chemical binding]; other site 1072459013375 putative Mg++ binding site [ion binding]; other site 1072459013376 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1072459013377 ATP-binding site [chemical binding]; other site 1072459013378 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1072459013379 hypothetical protein; Provisional; Region: PRK10030 1072459013380 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 1072459013381 dimerization interface [polypeptide binding]; other site 1072459013382 DNA binding site [nucleotide binding] 1072459013383 corepressor binding sites; other site 1072459013384 cystathionine gamma-synthase; Provisional; Region: PRK08045 1072459013385 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1072459013386 homodimer interface [polypeptide binding]; other site 1072459013387 substrate-cofactor binding pocket; other site 1072459013388 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1072459013389 catalytic residue [active] 1072459013390 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 1072459013391 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 1072459013392 putative catalytic residues [active] 1072459013393 putative nucleotide binding site [chemical binding]; other site 1072459013394 putative aspartate binding site [chemical binding]; other site 1072459013395 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 1072459013396 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1072459013397 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1072459013398 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 1072459013399 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1072459013400 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1072459013401 active site 1072459013402 metal binding site [ion binding]; metal-binding site 1072459013403 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1072459013404 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1072459013405 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1072459013406 active site 1072459013407 metal binding site [ion binding]; metal-binding site 1072459013408 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1072459013409 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1072459013410 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1072459013411 active site 1072459013412 metal binding site [ion binding]; metal-binding site 1072459013413 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1072459013414 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1072459013415 FAD binding site [chemical binding]; other site 1072459013416 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1072459013417 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 1072459013418 heme binding site [chemical binding]; other site 1072459013419 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1072459013420 EamA-like transporter family; Region: EamA; pfam00892 1072459013421 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1072459013422 EamA-like transporter family; Region: EamA; pfam00892 1072459013423 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738 1072459013424 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1072459013425 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 1072459013426 dimer interface [polypeptide binding]; other site 1072459013427 active site 1072459013428 metal binding site [ion binding]; metal-binding site 1072459013429 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1072459013430 active site 1072459013431 intersubunit interactions; other site 1072459013432 catalytic residue [active] 1072459013433 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1072459013434 dimerization domain swap beta strand [polypeptide binding]; other site 1072459013435 regulatory protein interface [polypeptide binding]; other site 1072459013436 active site 1072459013437 regulatory phosphorylation site [posttranslational modification]; other site 1072459013438 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1072459013439 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1072459013440 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1072459013441 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1072459013442 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1072459013443 active site 1072459013444 phosphorylation site [posttranslational modification] 1072459013445 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 1072459013446 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1072459013447 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1072459013448 active site 1072459013449 P-loop; other site 1072459013450 phosphorylation site [posttranslational modification] 1072459013451 putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983 1072459013452 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 1072459013453 dimer interface [polypeptide binding]; other site 1072459013454 active site 1072459013455 glycine loop; other site 1072459013456 pyruvate formate lyase II activase; Provisional; Region: PRK10076 1072459013457 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1072459013458 active site 1072459013459 P-loop; other site 1072459013460 phosphorylation site [posttranslational modification] 1072459013461 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1072459013462 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1072459013463 hypothetical protein; Provisional; Region: PRK10649 1072459013464 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1072459013465 Sulfatase; Region: Sulfatase; pfam00884 1072459013466 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 1072459013467 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1072459013468 acetylornithine deacetylase; Provisional; Region: PRK05111 1072459013469 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 1072459013470 metal binding site [ion binding]; metal-binding site 1072459013471 putative dimer interface [polypeptide binding]; other site 1072459013472 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1072459013473 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1072459013474 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 1072459013475 nucleotide binding site [chemical binding]; other site 1072459013476 N-acetyl-L-glutamate binding site [chemical binding]; other site 1072459013477 argininosuccinate lyase; Provisional; Region: PRK04833 1072459013478 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1072459013479 active sites [active] 1072459013480 tetramer interface [polypeptide binding]; other site 1072459013481 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1072459013482 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1072459013483 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1072459013484 dimerization interface [polypeptide binding]; other site 1072459013485 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1072459013486 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1072459013487 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1072459013488 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 1072459013489 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1072459013490 hypothetical protein; Provisional; Region: PRK11056 1072459013491 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 1072459013492 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1072459013493 S-adenosylmethionine binding site [chemical binding]; other site 1072459013494 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 1072459013495 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1072459013496 N-terminal plug; other site 1072459013497 ligand-binding site [chemical binding]; other site 1072459013498 glutamate racemase; Provisional; Region: PRK00865 1072459013499 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 1072459013500 FAD binding domain; Region: FAD_binding_4; pfam01565 1072459013501 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1072459013502 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1072459013503 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 1072459013504 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1072459013505 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1072459013506 pantothenate kinase; Provisional; Region: PRK05439 1072459013507 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1072459013508 ATP-binding site [chemical binding]; other site 1072459013509 CoA-binding site [chemical binding]; other site 1072459013510 Mg2+-binding site [ion binding]; other site 1072459013511 elongation factor Tu; Reviewed; Region: PRK00049 1072459013512 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1072459013513 G1 box; other site 1072459013514 GEF interaction site [polypeptide binding]; other site 1072459013515 GTP/Mg2+ binding site [chemical binding]; other site 1072459013516 Switch I region; other site 1072459013517 G2 box; other site 1072459013518 G3 box; other site 1072459013519 Switch II region; other site 1072459013520 G4 box; other site 1072459013521 G5 box; other site 1072459013522 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1072459013523 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1072459013524 Antibiotic Binding Site [chemical binding]; other site 1072459013525 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 1072459013526 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1072459013527 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1072459013528 putative homodimer interface [polypeptide binding]; other site 1072459013529 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1072459013530 heterodimer interface [polypeptide binding]; other site 1072459013531 homodimer interface [polypeptide binding]; other site 1072459013532 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1072459013533 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1072459013534 23S rRNA interface [nucleotide binding]; other site 1072459013535 L7/L12 interface [polypeptide binding]; other site 1072459013536 putative thiostrepton binding site; other site 1072459013537 L25 interface [polypeptide binding]; other site 1072459013538 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1072459013539 mRNA/rRNA interface [nucleotide binding]; other site 1072459013540 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1072459013541 23S rRNA interface [nucleotide binding]; other site 1072459013542 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1072459013543 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1072459013544 core dimer interface [polypeptide binding]; other site 1072459013545 peripheral dimer interface [polypeptide binding]; other site 1072459013546 L10 interface [polypeptide binding]; other site 1072459013547 L11 interface [polypeptide binding]; other site 1072459013548 putative EF-Tu interaction site [polypeptide binding]; other site 1072459013549 putative EF-G interaction site [polypeptide binding]; other site 1072459013550 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1072459013551 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1072459013552 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1072459013553 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1072459013554 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 1072459013555 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1072459013556 RPB3 interaction site [polypeptide binding]; other site 1072459013557 RPB1 interaction site [polypeptide binding]; other site 1072459013558 RPB11 interaction site [polypeptide binding]; other site 1072459013559 RPB10 interaction site [polypeptide binding]; other site 1072459013560 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1072459013561 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1072459013562 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1072459013563 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1072459013564 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1072459013565 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1072459013566 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1072459013567 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1072459013568 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1072459013569 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1072459013570 DNA binding site [nucleotide binding] 1072459013571 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1072459013572 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1072459013573 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1072459013574 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1072459013575 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1072459013576 substrate binding site [chemical binding]; other site 1072459013577 dimer interface [polypeptide binding]; other site 1072459013578 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1072459013579 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1072459013580 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 1072459013581 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1072459013582 FeS/SAM binding site; other site 1072459013583 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1072459013584 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1072459013585 ThiS interaction site; other site 1072459013586 putative active site [active] 1072459013587 tetramer interface [polypeptide binding]; other site 1072459013588 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1072459013589 thiS-thiF/thiG interaction site; other site 1072459013590 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1072459013591 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 1072459013592 ATP binding site [chemical binding]; other site 1072459013593 substrate interface [chemical binding]; other site 1072459013594 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1072459013595 thiamine phosphate binding site [chemical binding]; other site 1072459013596 active site 1072459013597 pyrophosphate binding site [ion binding]; other site 1072459013598 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1072459013599 ThiC-associated domain; Region: ThiC-associated; pfam13667 1072459013600 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1072459013601 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 1072459013602 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 1072459013603 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1072459013604 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1072459013605 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1072459013606 putative NADH binding site [chemical binding]; other site 1072459013607 putative active site [active] 1072459013608 nudix motif; other site 1072459013609 putative metal binding site [ion binding]; other site 1072459013610 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1072459013611 substrate binding site [chemical binding]; other site 1072459013612 active site 1072459013613 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 1072459013614 Active_site [active] 1072459013615 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 1072459013616 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1072459013617 IHF dimer interface [polypeptide binding]; other site 1072459013618 IHF - DNA interface [nucleotide binding]; other site 1072459013619 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 1072459013620 zinc resistance protein; Provisional; Region: zraP; PRK11546 1072459013621 dimer interface [polypeptide binding]; other site 1072459013622 sensor protein ZraS; Provisional; Region: PRK10364 1072459013623 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1072459013624 dimer interface [polypeptide binding]; other site 1072459013625 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1072459013626 ATP binding site [chemical binding]; other site 1072459013627 Mg2+ binding site [ion binding]; other site 1072459013628 G-X-G motif; other site 1072459013629 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 1072459013630 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1072459013631 active site 1072459013632 phosphorylation site [posttranslational modification] 1072459013633 intermolecular recognition site; other site 1072459013634 dimerization interface [polypeptide binding]; other site 1072459013635 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1072459013636 Walker A motif; other site 1072459013637 ATP binding site [chemical binding]; other site 1072459013638 Walker B motif; other site 1072459013639 arginine finger; other site 1072459013640 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1072459013641 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1072459013642 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1072459013643 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1072459013644 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1072459013645 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1072459013646 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1072459013647 purine monophosphate binding site [chemical binding]; other site 1072459013648 dimer interface [polypeptide binding]; other site 1072459013649 putative catalytic residues [active] 1072459013650 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1072459013651 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1072459013652 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1072459013653 Coenzyme A binding pocket [chemical binding]; other site 1072459013654 homoserine O-succinyltransferase; Provisional; Region: PRK05368 1072459013655 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1072459013656 proposed active site lysine [active] 1072459013657 conserved cys residue [active] 1072459013658 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 1072459013659 malate synthase A; Region: malate_syn_A; TIGR01344 1072459013660 active site 1072459013661 isocitrate lyase; Provisional; Region: PRK15063 1072459013662 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1072459013663 tetramer interface [polypeptide binding]; other site 1072459013664 active site 1072459013665 Mg2+/Mn2+ binding site [ion binding]; other site 1072459013666 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 1072459013667 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 1072459013668 transcriptional repressor IclR; Provisional; Region: PRK11569 1072459013669 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1072459013670 Bacterial transcriptional regulator; Region: IclR; pfam01614 1072459013671 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 1072459013672 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1072459013673 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1072459013674 substrate binding pocket [chemical binding]; other site 1072459013675 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1072459013676 B12 binding site [chemical binding]; other site 1072459013677 cobalt ligand [ion binding]; other site 1072459013678 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1072459013679 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1072459013680 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1072459013681 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1072459013682 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 1072459013683 active site pocket [active] 1072459013684 oxyanion hole [active] 1072459013685 catalytic triad [active] 1072459013686 active site nucleophile [active] 1072459013687 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 1072459013688 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1072459013689 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1072459013690 shikimate binding site; other site 1072459013691 NAD(P) binding site [chemical binding]; other site 1072459013692 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 1072459013693 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1072459013694 putative NAD(P) binding site [chemical binding]; other site 1072459013695 catalytic Zn binding site [ion binding]; other site 1072459013696 PTS system, mannose/fructose/sorbose family, IID component; Region: EIID-AGA; TIGR00828 1072459013697 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 1072459013698 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1072459013699 active site 1072459013700 phosphorylation site [posttranslational modification] 1072459013701 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1072459013702 active pocket/dimerization site; other site 1072459013703 active site 1072459013704 phosphorylation site [posttranslational modification] 1072459013705 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 1072459013706 classical (c) SDRs; Region: SDR_c; cd05233 1072459013707 NAD(P) binding site [chemical binding]; other site 1072459013708 active site 1072459013709 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1072459013710 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1072459013711 putative DNA binding site [nucleotide binding]; other site 1072459013712 putative Zn2+ binding site [ion binding]; other site 1072459013713 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1072459013714 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 1072459013715 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1072459013716 RNA binding surface [nucleotide binding]; other site 1072459013717 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 1072459013718 probable active site [active] 1072459013719 hypothetical protein; Provisional; Region: PRK10515 1072459013720 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1072459013721 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1072459013722 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 1072459013723 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1072459013724 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 1072459013725 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 1072459013726 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 1072459013727 Phage Tail Collar Domain; Region: Collar; pfam07484 1072459013728 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 1072459013729 Baseplate J-like protein; Region: Baseplate_J; cl01294 1072459013730 Phage baseplate assembly protein W [General function prediction only]; Region: COG3628 1072459013731 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 1072459013732 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 1072459013733 Phage protein D [General function prediction only]; Region: COG3500 1072459013734 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 1072459013735 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 1072459013736 potential frameshift: common BLAST hit: gi|218702678|ref|YP_002410307.1| putative phage tail protein 1072459013737 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 1072459013738 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 1072459013739 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 1072459013740 Phage tail tube protein FII [General function prediction only]; Region: COG3498 1072459013741 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 1072459013742 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 1072459013743 Gp37 protein; Region: Gp37; pfam09646 1072459013744 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1072459013745 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1072459013746 catalytic residue [active] 1072459013747 Protein of unknown function (DUF4063); Region: DUF4063; pfam13272 1072459013748 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1072459013749 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1072459013750 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 1072459013751 Mor transcription activator family; Region: Mor; pfam08765 1072459013752 aspartate kinase III; Validated; Region: PRK09084 1072459013753 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1072459013754 nucleotide binding site [chemical binding]; other site 1072459013755 substrate binding site [chemical binding]; other site 1072459013756 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1072459013757 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 1072459013758 dimer interface [polypeptide binding]; other site 1072459013759 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1072459013760 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1072459013761 active site 1072459013762 dimer interface [polypeptide binding]; other site 1072459013763 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1072459013764 dimer interface [polypeptide binding]; other site 1072459013765 active site 1072459013766 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 1072459013767 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 1072459013768 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 1072459013769 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 1072459013770 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1072459013771 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1072459013772 dimer interface [polypeptide binding]; other site 1072459013773 conserved gate region; other site 1072459013774 putative PBP binding loops; other site 1072459013775 ABC-ATPase subunit interface; other site 1072459013776 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1072459013777 dimer interface [polypeptide binding]; other site 1072459013778 conserved gate region; other site 1072459013779 putative PBP binding loops; other site 1072459013780 ABC-ATPase subunit interface; other site 1072459013781 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 1072459013782 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 1072459013783 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1072459013784 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 1072459013785 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1072459013786 Walker A/P-loop; other site 1072459013787 ATP binding site [chemical binding]; other site 1072459013788 Q-loop/lid; other site 1072459013789 ABC transporter signature motif; other site 1072459013790 Walker B; other site 1072459013791 D-loop; other site 1072459013792 H-loop/switch region; other site 1072459013793 TOBE domain; Region: TOBE_2; pfam08402 1072459013794 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1072459013795 trimer interface; other site 1072459013796 sugar binding site [chemical binding]; other site 1072459013797 maltose regulon periplasmic protein; Provisional; Region: PRK10564 1072459013798 hypothetical protein; Validated; Region: PRK09718 1072459013799 SopA-like central domain; Region: SopA; pfam13981 1072459013800 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 1072459013801 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 1072459013802 UbiA prenyltransferase family; Region: UbiA; pfam01040 1072459013803 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 1072459013804 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1072459013805 putative acyl-acceptor binding pocket; other site 1072459013806 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1072459013807 LexA repressor; Validated; Region: PRK00215 1072459013808 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1072459013809 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1072459013810 Catalytic site [active] 1072459013811 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 1072459013812 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1072459013813 hypothetical protein; Provisional; Region: PRK10428 1072459013814 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1072459013815 metal binding site 2 [ion binding]; metal-binding site 1072459013816 putative DNA binding helix; other site 1072459013817 metal binding site 1 [ion binding]; metal-binding site 1072459013818 dimer interface [polypeptide binding]; other site 1072459013819 structural Zn2+ binding site [ion binding]; other site 1072459013820 Protein of unknown function (DUF2713); Region: DUF2713; pfam10897 1072459013821 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 1072459013822 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1072459013823 FMN binding site [chemical binding]; other site 1072459013824 active site 1072459013825 catalytic residues [active] 1072459013826 substrate binding site [chemical binding]; other site 1072459013827 phage shock protein G; Reviewed; Region: pspG; PRK09459 1072459013828 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1072459013829 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1072459013830 NADP binding site [chemical binding]; other site 1072459013831 dimer interface [polypeptide binding]; other site 1072459013832 replicative DNA helicase; Provisional; Region: PRK08006 1072459013833 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1072459013834 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1072459013835 Walker A motif; other site 1072459013836 ATP binding site [chemical binding]; other site 1072459013837 Walker B motif; other site 1072459013838 DNA binding loops [nucleotide binding] 1072459013839 alanine racemase; Reviewed; Region: alr; PRK00053 1072459013840 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1072459013841 active site 1072459013842 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1072459013843 substrate binding site [chemical binding]; other site 1072459013844 catalytic residues [active] 1072459013845 dimer interface [polypeptide binding]; other site 1072459013846 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1072459013847 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1072459013848 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1072459013849 homodimer interface [polypeptide binding]; other site 1072459013850 catalytic residue [active] 1072459013851 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1072459013852 active site 1072459013853 motif I; other site 1072459013854 motif II; other site 1072459013855 secondary thiamine-phosphate synthase enzyme; Region: TIGR00149_YjbQ 1072459013856 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 1072459013857 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1072459013858 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1072459013859 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1072459013860 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1072459013861 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1072459013862 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1072459013863 dimer interface [polypeptide binding]; other site 1072459013864 ssDNA binding site [nucleotide binding]; other site 1072459013865 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1072459013866 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 1072459013867 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 1072459013868 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1072459013869 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1072459013870 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 1072459013871 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1072459013872 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 1072459013873 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 1072459013874 DNA binding residues [nucleotide binding] 1072459013875 dimer interface [polypeptide binding]; other site 1072459013876 [2Fe-2S] cluster binding site [ion binding]; other site 1072459013877 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1072459013878 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1072459013879 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1072459013880 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1072459013881 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1072459013882 Na binding site [ion binding]; other site 1072459013883 Predicted membrane protein [Function unknown]; Region: COG3162 1072459013884 acetyl-CoA synthetase; Provisional; Region: PRK00174 1072459013885 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1072459013886 active site 1072459013887 CoA binding site [chemical binding]; other site 1072459013888 acyl-activating enzyme (AAE) consensus motif; other site 1072459013889 AMP binding site [chemical binding]; other site 1072459013890 acetate binding site [chemical binding]; other site 1072459013891 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 1072459013892 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 1072459013893 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 1072459013894 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 1072459013895 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 1072459013896 heme lyase subunit NrfE; Provisional; Region: PRK10369 1072459013897 formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144 1072459013898 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 1072459013899 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1072459013900 binding surface 1072459013901 TPR motif; other site 1072459013902 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 1072459013903 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1072459013904 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1072459013905 Sel1-like repeats; Region: SEL1; smart00671 1072459013906 putative outer membrane efflux protein MdtP; Provisional; Region: PRK09915 1072459013907 multidrug efflux system protein MdtO; Provisional; Region: PRK11427 1072459013908 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1072459013909 multidrug resistance protein MdtN; Provisional; Region: PRK10476 1072459013910 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1072459013911 HlyD family secretion protein; Region: HlyD_3; pfam13437 1072459013912 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 1072459013913 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1072459013914 D-allose kinase; Provisional; Region: PRK09698 1072459013915 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1072459013916 nucleotide binding site [chemical binding]; other site 1072459013917 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1072459013918 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1072459013919 substrate binding site [chemical binding]; other site 1072459013920 hexamer interface [polypeptide binding]; other site 1072459013921 metal binding site [ion binding]; metal-binding site 1072459013922 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1072459013923 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1072459013924 TM-ABC transporter signature motif; other site 1072459013925 D-allose transporter ATP-binding protein; Provisional; Region: PRK09700 1072459013926 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1072459013927 Walker A/P-loop; other site 1072459013928 ATP binding site [chemical binding]; other site 1072459013929 Q-loop/lid; other site 1072459013930 ABC transporter signature motif; other site 1072459013931 Walker B; other site 1072459013932 D-loop; other site 1072459013933 H-loop/switch region; other site 1072459013934 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1072459013935 D-allose transporter subunit; Provisional; Region: PRK09701 1072459013936 Periplasmic allose-binding domain of bacterial transport systems that function as a primary receptor of active transport and chemotaxis; Region: PBP1_allose_binding; cd06320 1072459013937 ligand binding site [chemical binding]; other site 1072459013938 dimerization interface [polypeptide binding]; other site 1072459013939 zinc binding site [ion binding]; other site 1072459013940 DNA-binding transcriptional repressor RpiR; Provisional; Region: PRK11337 1072459013941 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1072459013942 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1072459013943 putative active site [active] 1072459013944 ribose 5-phosphate isomerase B; Region: rpiB; TIGR01120 1072459013945 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 1072459013946 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1072459013947 Coenzyme A binding pocket [chemical binding]; other site 1072459013948 ribose 1,5-bisphosphokinase; Provisional; Region: PRK10078 1072459013949 AAA domain; Region: AAA_18; pfam13238 1072459013950 active site 1072459013951 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 1072459013952 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1072459013953 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 1072459013954 active site 1072459013955 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 1072459013956 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1072459013957 Walker A/P-loop; other site 1072459013958 ATP binding site [chemical binding]; other site 1072459013959 Q-loop/lid; other site 1072459013960 ABC transporter signature motif; other site 1072459013961 Walker B; other site 1072459013962 D-loop; other site 1072459013963 H-loop/switch region; other site 1072459013964 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 1072459013965 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1072459013966 Walker A/P-loop; other site 1072459013967 ATP binding site [chemical binding]; other site 1072459013968 Q-loop/lid; other site 1072459013969 ABC transporter signature motif; other site 1072459013970 Walker B; other site 1072459013971 D-loop; other site 1072459013972 H-loop/switch region; other site 1072459013973 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1072459013974 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 1072459013975 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnI; COG3626 1072459013976 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnH; COG3625 1072459013977 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 1072459013978 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 1072459013979 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1072459013980 DNA-binding site [nucleotide binding]; DNA binding site 1072459013981 UTRA domain; Region: UTRA; pfam07702 1072459013982 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 1072459013983 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1072459013984 dimer interface [polypeptide binding]; other site 1072459013985 conserved gate region; other site 1072459013986 putative PBP binding loops; other site 1072459013987 ABC-ATPase subunit interface; other site 1072459013988 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 1072459013989 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1072459013990 substrate binding pocket [chemical binding]; other site 1072459013991 membrane-bound complex binding site; other site 1072459013992 hinge residues; other site 1072459013993 phosphonate/organophosphate ester transporter subunit; Provisional; Region: PRK09984 1072459013994 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 1072459013995 Walker A/P-loop; other site 1072459013996 ATP binding site [chemical binding]; other site 1072459013997 Q-loop/lid; other site 1072459013998 ABC transporter signature motif; other site 1072459013999 Walker B; other site 1072459014000 D-loop; other site 1072459014001 H-loop/switch region; other site 1072459014002 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1072459014003 dimer interface [polypeptide binding]; other site 1072459014004 hypothetical protein; Provisional; Region: PRK10220 1072459014005 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1072459014006 PhnA protein; Region: PhnA; pfam03831 1072459014007 hypothetical protein; Provisional; Region: PRK09866 1072459014008 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1072459014009 G1 box; other site 1072459014010 GTP/Mg2+ binding site [chemical binding]; other site 1072459014011 G2 box; other site 1072459014012 Switch I region; other site 1072459014013 G3 box; other site 1072459014014 Switch II region; other site 1072459014015 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1072459014016 G2 box; other site 1072459014017 Switch I region; other site 1072459014018 G3 box; other site 1072459014019 Switch II region; other site 1072459014020 G4 box; other site 1072459014021 G5 box; other site 1072459014022 YjcZ-like protein; Region: YjcZ; pfam13990 1072459014023 proline/glycine betaine transporter; Provisional; Region: PRK10642 1072459014024 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459014025 putative substrate translocation pore; other site 1072459014026 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 1072459014027 sensor protein BasS/PmrB; Provisional; Region: PRK10755 1072459014028 HAMP domain; Region: HAMP; pfam00672 1072459014029 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1072459014030 dimer interface [polypeptide binding]; other site 1072459014031 phosphorylation site [posttranslational modification] 1072459014032 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1072459014033 ATP binding site [chemical binding]; other site 1072459014034 Mg2+ binding site [ion binding]; other site 1072459014035 G-X-G motif; other site 1072459014036 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 1072459014037 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1072459014038 active site 1072459014039 phosphorylation site [posttranslational modification] 1072459014040 intermolecular recognition site; other site 1072459014041 dimerization interface [polypeptide binding]; other site 1072459014042 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1072459014043 DNA binding site [nucleotide binding] 1072459014044 putative metal dependent hydrolase; Provisional; Region: PRK11598 1072459014045 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1072459014046 Sulfatase; Region: Sulfatase; pfam00884 1072459014047 arginine:agmatin antiporter; Provisional; Region: PRK10644 1072459014048 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1072459014049 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1072459014050 arginine decarboxylase; Provisional; Region: PRK15029 1072459014051 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1072459014052 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1072459014053 homodimer interface [polypeptide binding]; other site 1072459014054 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1072459014055 catalytic residue [active] 1072459014056 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1072459014057 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 1072459014058 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1072459014059 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1072459014060 alpha-galactosidase; Provisional; Region: PRK15076 1072459014061 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 1072459014062 NAD binding site [chemical binding]; other site 1072459014063 sugar binding site [chemical binding]; other site 1072459014064 divalent metal binding site [ion binding]; other site 1072459014065 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1072459014066 dimer interface [polypeptide binding]; other site 1072459014067 melibiose:sodium symporter; Provisional; Region: PRK10429 1072459014068 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1072459014069 hypothetical protein; Provisional; Region: PRK09867 1072459014070 fumarate hydratase; Provisional; Region: PRK15389 1072459014071 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 1072459014072 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1072459014073 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1072459014074 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 1072459014075 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 1072459014076 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1072459014077 active site 1072459014078 phosphorylation site [posttranslational modification] 1072459014079 intermolecular recognition site; other site 1072459014080 dimerization interface [polypeptide binding]; other site 1072459014081 Transcriptional regulator; Region: CitT; pfam12431 1072459014082 sensory histidine kinase DcuS; Provisional; Region: PRK11086 1072459014083 PAS domain; Region: PAS; smart00091 1072459014084 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1072459014085 ATP binding site [chemical binding]; other site 1072459014086 Mg2+ binding site [ion binding]; other site 1072459014087 G-X-G motif; other site 1072459014088 Uncharacterized conserved protein [Function unknown]; Region: COG3592 1072459014089 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1072459014090 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 1072459014091 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 1072459014092 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 1072459014093 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1072459014094 dimer interface [polypeptide binding]; other site 1072459014095 putative anticodon binding site; other site 1072459014096 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1072459014097 motif 1; other site 1072459014098 active site 1072459014099 motif 2; other site 1072459014100 motif 3; other site 1072459014101 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459014102 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1072459014103 lysine decarboxylase CadA; Provisional; Region: PRK15400 1072459014104 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1072459014105 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1072459014106 homodimer interface [polypeptide binding]; other site 1072459014107 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1072459014108 catalytic residue [active] 1072459014109 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1072459014110 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 1072459014111 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 1072459014112 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1072459014113 DNA binding site [nucleotide binding] 1072459014114 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1072459014115 putative transposase OrfB; Reviewed; Region: PHA02517 1072459014116 HTH-like domain; Region: HTH_21; pfam13276 1072459014117 Integrase core domain; Region: rve; pfam00665 1072459014118 Integrase core domain; Region: rve_3; pfam13683 1072459014119 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 1072459014120 FaeA-like protein; Region: FaeA; pfam04703 1072459014121 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1072459014122 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1072459014123 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 1072459014124 PapC N-terminal domain; Region: PapC_N; pfam13954 1072459014125 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1072459014126 PapC C-terminal domain; Region: PapC_C; pfam13953 1072459014127 putative fimbrial chaperone protein StfD; Provisional; Region: PRK15285 1072459014128 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1072459014129 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1072459014130 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1072459014131 Fimbrial protein; Region: Fimbrial; pfam00419 1072459014132 Fimbrial protein; Region: Fimbrial; pfam00419 1072459014133 PapG carbohydrate / receptor binding domain (CBD); PapG, the adhesin of the P-pili, is situated at the tip, mediating the attachment of uropathogenic Escherichia coli to the uroepithelium of the human kidney; PapG has a two-domain architecture: a...; Region: PapG_CBD; cd00239 1072459014134 putative membrane interaction site; other site 1072459014135 receptor/carbohydrate binding site; other site 1072459014136 PapG chaperone-binding domain; Region: PapG_C; pfam03628 1072459014137 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 1072459014138 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 1072459014139 Sulfatase; Region: Sulfatase; cl17466 1072459014140 Part of AAA domain; Region: AAA_19; pfam13245 1072459014141 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1072459014142 AAA domain; Region: AAA_12; pfam13087 1072459014143 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1072459014144 putative active site [active] 1072459014145 catalytic site [active] 1072459014146 integrase; Provisional; Region: PRK09692 1072459014147 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1072459014148 active site 1072459014149 Int/Topo IB signature motif; other site 1072459014150 putative transcriptional regulator; Provisional; Region: PRK11640 1072459014151 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1072459014152 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 1072459014153 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 1072459014154 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1072459014155 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1072459014156 DsbD alpha interface [polypeptide binding]; other site 1072459014157 catalytic residues [active] 1072459014158 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 1072459014159 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1072459014160 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 1072459014161 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1072459014162 Aspartase; Region: Aspartase; cd01357 1072459014163 active sites [active] 1072459014164 tetramer interface [polypeptide binding]; other site 1072459014165 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 1072459014166 putative transporter; Provisional; Region: PRK11021 1072459014167 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1072459014168 oligomerisation interface [polypeptide binding]; other site 1072459014169 mobile loop; other site 1072459014170 roof hairpin; other site 1072459014171 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1072459014172 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1072459014173 ring oligomerisation interface [polypeptide binding]; other site 1072459014174 ATP/Mg binding site [chemical binding]; other site 1072459014175 stacking interactions; other site 1072459014176 hinge regions; other site 1072459014177 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 1072459014178 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 1072459014179 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1072459014180 FeS/SAM binding site; other site 1072459014181 elongation factor P; Validated; Region: PRK00529 1072459014182 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1072459014183 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1072459014184 RNA binding site [nucleotide binding]; other site 1072459014185 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1072459014186 RNA binding site [nucleotide binding]; other site 1072459014187 entericidin A; Provisional; Region: PRK09810 1072459014188 entericidin B membrane lipoprotein; Provisional; Region: PRK10081 1072459014189 multidrug efflux system protein; Provisional; Region: PRK11431 1072459014190 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 1072459014191 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 1072459014192 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 1072459014193 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1072459014194 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 1072459014195 Iron-sulfur protein interface; other site 1072459014196 proximal quinone binding site [chemical binding]; other site 1072459014197 C-subunit interface; other site 1072459014198 distal quinone binding site; other site 1072459014199 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 1072459014200 D-subunit interface [polypeptide binding]; other site 1072459014201 Iron-sulfur protein interface; other site 1072459014202 proximal quinone binding site [chemical binding]; other site 1072459014203 distal quinone binding site [chemical binding]; other site 1072459014204 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 1072459014205 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1072459014206 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 1072459014207 L-aspartate oxidase; Provisional; Region: PRK06175 1072459014208 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1072459014209 poxB regulator PoxA; Provisional; Region: PRK09350 1072459014210 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1072459014211 motif 1; other site 1072459014212 dimer interface [polypeptide binding]; other site 1072459014213 active site 1072459014214 motif 2; other site 1072459014215 motif 3; other site 1072459014216 inner membrane transporter YjeM; Provisional; Region: PRK15238 1072459014217 putative mechanosensitive channel protein; Provisional; Region: PRK10929 1072459014218 linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated...; Region: H15; cl00073 1072459014219 DNA-binding site [nucleotide binding]; DNA binding site 1072459014220 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 1072459014221 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1072459014222 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 1072459014223 GTPase RsgA; Reviewed; Region: PRK12288 1072459014224 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1072459014225 RNA binding site [nucleotide binding]; other site 1072459014226 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1072459014227 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1072459014228 GTP/Mg2+ binding site [chemical binding]; other site 1072459014229 G4 box; other site 1072459014230 G5 box; other site 1072459014231 G1 box; other site 1072459014232 Switch I region; other site 1072459014233 G2 box; other site 1072459014234 G3 box; other site 1072459014235 Switch II region; other site 1072459014236 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1072459014237 catalytic site [active] 1072459014238 putative active site [active] 1072459014239 putative substrate binding site [chemical binding]; other site 1072459014240 dimer interface [polypeptide binding]; other site 1072459014241 epoxyqueuosine reductase; Region: TIGR00276 1072459014242 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1072459014243 putative carbohydrate kinase; Provisional; Region: PRK10565 1072459014244 yjeF N-terminal region; Region: yjeF_nterm; TIGR00197 1072459014245 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1072459014246 putative substrate binding site [chemical binding]; other site 1072459014247 putative ATP binding site [chemical binding]; other site 1072459014248 ADP-binding protein; Provisional; Region: PRK10646 1072459014249 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 1072459014250 AMIN domain; Region: AMIN; pfam11741 1072459014251 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1072459014252 active site 1072459014253 metal binding site [ion binding]; metal-binding site 1072459014254 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1072459014255 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1072459014256 ATP binding site [chemical binding]; other site 1072459014257 Mg2+ binding site [ion binding]; other site 1072459014258 G-X-G motif; other site 1072459014259 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 1072459014260 ATP binding site [chemical binding]; other site 1072459014261 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1072459014262 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1072459014263 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1072459014264 bacterial Hfq-like; Region: Hfq; cd01716 1072459014265 hexamer interface [polypeptide binding]; other site 1072459014266 Sm1 motif; other site 1072459014267 RNA binding site [nucleotide binding]; other site 1072459014268 Sm2 motif; other site 1072459014269 GTPase HflX; Provisional; Region: PRK11058 1072459014270 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1072459014271 HflX GTPase family; Region: HflX; cd01878 1072459014272 G1 box; other site 1072459014273 GTP/Mg2+ binding site [chemical binding]; other site 1072459014274 Switch I region; other site 1072459014275 G2 box; other site 1072459014276 G3 box; other site 1072459014277 Switch II region; other site 1072459014278 G4 box; other site 1072459014279 G5 box; other site 1072459014280 FtsH protease regulator HflK; Provisional; Region: PRK10930 1072459014281 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 1072459014282 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 1072459014283 FtsH protease regulator HflC; Provisional; Region: PRK11029 1072459014284 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1072459014285 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 1072459014286 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1072459014287 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1072459014288 GDP-binding site [chemical binding]; other site 1072459014289 ACT binding site; other site 1072459014290 IMP binding site; other site 1072459014291 Predicted transcriptional regulator [Transcription]; Region: COG1959 1072459014292 transcriptional repressor NsrR; Provisional; Region: PRK11014 1072459014293 exoribonuclease R; Provisional; Region: PRK11642 1072459014294 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 1072459014295 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1072459014296 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1072459014297 RNB domain; Region: RNB; pfam00773 1072459014298 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1072459014299 RNA binding site [nucleotide binding]; other site 1072459014300 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 1072459014301 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1072459014302 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1072459014303 Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; cl01551 1072459014304 PspA/IM30 family; Region: PspA_IM30; pfam04012 1072459014305 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 1072459014306 Predicted membrane protein [Function unknown]; Region: COG3766 1072459014307 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1072459014308 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1072459014309 Protein of unknown function (DUF1190); Region: DUF1190; cl10031 1072459014310 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1072459014311 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 1072459014312 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 1072459014313 FAD binding site [chemical binding]; other site 1072459014314 substrate binding site [chemical binding]; other site 1072459014315 catalytic residues [active] 1072459014316 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1072459014317 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 1072459014318 esterase; Provisional; Region: PRK10566 1072459014319 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1072459014320 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1072459014321 transcriptional repressor UlaR; Provisional; Region: PRK13509 1072459014322 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1072459014323 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1072459014324 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 1072459014325 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1072459014326 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 1072459014327 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 1072459014328 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1072459014329 active site 1072459014330 P-loop; other site 1072459014331 phosphorylation site [posttranslational modification] 1072459014332 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1072459014333 active site 1072459014334 phosphorylation site [posttranslational modification] 1072459014335 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1072459014336 active site 1072459014337 dimer interface [polypeptide binding]; other site 1072459014338 magnesium binding site [ion binding]; other site 1072459014339 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 1072459014340 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1072459014341 AP (apurinic/apyrimidinic) site pocket; other site 1072459014342 DNA interaction; other site 1072459014343 Metal-binding active site; metal-binding site 1072459014344 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1072459014345 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1072459014346 intersubunit interface [polypeptide binding]; other site 1072459014347 active site 1072459014348 Zn2+ binding site [ion binding]; other site 1072459014349 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1072459014350 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1072459014351 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1072459014352 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1072459014353 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1072459014354 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1072459014355 Protein of unknown function (DUF2686); Region: DUF2686; pfam10887 1072459014356 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1072459014357 D-galactonate transporter; Region: 2A0114; TIGR00893 1072459014358 putative substrate translocation pore; other site 1072459014359 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 1072459014360 L-aspartate oxidase; Provisional; Region: PRK06175 1072459014361 L-aspartate oxidase; Provisional; Region: PRK06175 1072459014362 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 1072459014363 Coenzyme A transferase; Region: CoA_trans; smart00882 1072459014364 Coenzyme A transferase; Region: CoA_trans; cl17247 1072459014365 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1072459014366 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1072459014367 substrate binding site [chemical binding]; other site 1072459014368 oxyanion hole (OAH) forming residues; other site 1072459014369 trimer interface [polypeptide binding]; other site 1072459014370 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1072459014371 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 1072459014372 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 1, classical (c) SDR; Region: BKR_1_SDR_c; cd05337 1072459014373 putative NAD(P) binding site [chemical binding]; other site 1072459014374 active site 1072459014375 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1072459014376 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1072459014377 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 1072459014378 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 1072459014379 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 1072459014380 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1072459014381 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1072459014382 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1072459014383 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 1072459014384 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 1072459014385 Hemerythrin-like domain; Region: Hr-like; cd12108 1072459014386 Fe binding site [ion binding]; other site 1072459014387 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1072459014388 EamA-like transporter family; Region: EamA; pfam00892 1072459014389 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1072459014390 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1072459014391 NADP binding site [chemical binding]; other site 1072459014392 Predicted transcriptional regulators [Transcription]; Region: COG1733 1072459014393 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1072459014394 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 1072459014395 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1072459014396 active site 1072459014397 metal binding site [ion binding]; metal-binding site 1072459014398 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1072459014399 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1072459014400 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1072459014401 active site 1072459014402 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 1072459014403 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 1072459014404 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1072459014405 Domain of unknown function DUF21; Region: DUF21; pfam01595 1072459014406 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1072459014407 Transporter associated domain; Region: CorC_HlyC; smart01091 1072459014408 methionine sulfoxide reductase A; Provisional; Region: PRK00058 1072459014409 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 1072459014410 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1072459014411 Surface antigen; Region: Bac_surface_Ag; pfam01103 1072459014412 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 1072459014413 Family of unknown function (DUF490); Region: DUF490; pfam04357 1072459014414 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1072459014415 putative active site pocket [active] 1072459014416 dimerization interface [polypeptide binding]; other site 1072459014417 putative catalytic residue [active] 1072459014418 antitoxin ChpS; Provisional; Region: PRK11347 1072459014419 toxin ChpB; Provisional; Region: PRK09812 1072459014420 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1072459014421 dimer interface [polypeptide binding]; other site 1072459014422 substrate binding site [chemical binding]; other site 1072459014423 metal binding sites [ion binding]; metal-binding site 1072459014424 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 1072459014425 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1072459014426 putative ligand binding site [chemical binding]; other site 1072459014427 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1072459014428 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1072459014429 Walker A/P-loop; other site 1072459014430 ATP binding site [chemical binding]; other site 1072459014431 Q-loop/lid; other site 1072459014432 ABC transporter signature motif; other site 1072459014433 Walker B; other site 1072459014434 D-loop; other site 1072459014435 H-loop/switch region; other site 1072459014436 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1072459014437 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1072459014438 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1072459014439 TM-ABC transporter signature motif; other site 1072459014440 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1072459014441 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1072459014442 TM-ABC transporter signature motif; other site 1072459014443 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 1072459014444 AMP binding site [chemical binding]; other site 1072459014445 metal binding site [ion binding]; metal-binding site 1072459014446 active site 1072459014447 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 1072459014448 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1072459014449 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1072459014450 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1072459014451 hypothetical protein; Provisional; Region: PRK05255 1072459014452 peptidase PmbA; Provisional; Region: PRK11040 1072459014453 cytochrome b562; Provisional; Region: PRK15058 1072459014454 bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235 1072459014455 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 1072459014456 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1072459014457 FeS/SAM binding site; other site 1072459014458 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 1072459014459 ATP cone domain; Region: ATP-cone; pfam03477 1072459014460 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1072459014461 effector binding site; other site 1072459014462 active site 1072459014463 Zn binding site [ion binding]; other site 1072459014464 glycine loop; other site 1072459014465 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 1072459014466 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1072459014467 Ca binding site [ion binding]; other site 1072459014468 active site 1072459014469 catalytic site [active] 1072459014470 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1072459014471 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 1072459014472 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1072459014473 active site turn [active] 1072459014474 phosphorylation site [posttranslational modification] 1072459014475 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1072459014476 trehalose repressor; Provisional; Region: treR; PRK09492 1072459014477 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1072459014478 DNA binding site [nucleotide binding] 1072459014479 domain linker motif; other site 1072459014480 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 1072459014481 dimerization interface [polypeptide binding]; other site 1072459014482 ligand binding site [chemical binding]; other site 1072459014483 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 1072459014484 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1072459014485 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1072459014486 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1072459014487 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1072459014488 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1072459014489 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1072459014490 homotrimer interaction site [polypeptide binding]; other site 1072459014491 putative active site [active] 1072459014492 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 1072459014493 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 1072459014494 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 1072459014495 aspartate carbamoyltransferase; Region: asp_carb_tr; TIGR00670 1072459014496 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1072459014497 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1072459014498 Arginine repressor [Transcription]; Region: ArgR; COG1438 1072459014499 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1072459014500 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1072459014501 Predicted membrane protein [Function unknown]; Region: COG1288 1072459014502 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1072459014503 ornithine carbamoyltransferase; Validated; Region: PRK02102 1072459014504 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1072459014505 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1072459014506 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 1072459014507 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1072459014508 putative substrate binding site [chemical binding]; other site 1072459014509 nucleotide binding site [chemical binding]; other site 1072459014510 nucleotide binding site [chemical binding]; other site 1072459014511 homodimer interface [polypeptide binding]; other site 1072459014512 arginine deiminase; Provisional; Region: PRK01388 1072459014513 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 1072459014514 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 1072459014515 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1072459014516 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1072459014517 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076 1072459014518 RNase E inhibitor protein; Provisional; Region: PRK11191 1072459014519 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1072459014520 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1072459014521 Coenzyme A binding pocket [chemical binding]; other site 1072459014522 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 1072459014523 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1072459014524 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1072459014525 HIGH motif; other site 1072459014526 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1072459014527 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1072459014528 active site 1072459014529 KMSKS motif; other site 1072459014530 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1072459014531 tRNA binding surface [nucleotide binding]; other site 1072459014532 anticodon binding site; other site 1072459014533 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1072459014534 DNA polymerase III subunit chi; Validated; Region: PRK05728 1072459014535 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1072459014536 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1072459014537 interface (dimer of trimers) [polypeptide binding]; other site 1072459014538 Substrate-binding/catalytic site; other site 1072459014539 Zn-binding sites [ion binding]; other site 1072459014540 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 1072459014541 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1072459014542 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 1072459014543 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1072459014544 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 1072459014545 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1072459014546 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 1072459014547 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1072459014548 DNA binding site [nucleotide binding] 1072459014549 domain linker motif; other site 1072459014550 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1072459014551 putative dimerization interface [polypeptide binding]; other site 1072459014552 putative ligand binding site [chemical binding]; other site 1072459014553 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1072459014554 gluconate transporter; Region: gntP; TIGR00791 1072459014555 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 1072459014556 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1072459014557 NADP binding site [chemical binding]; other site 1072459014558 homodimer interface [polypeptide binding]; other site 1072459014559 active site 1072459014560 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 1072459014561 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 1072459014562 putative NAD(P) binding site [chemical binding]; other site 1072459014563 catalytic Zn binding site [ion binding]; other site 1072459014564 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1072459014565 ATP-binding site [chemical binding]; other site 1072459014566 Gluconate-6-phosphate binding site [chemical binding]; other site 1072459014567 Shikimate kinase; Region: SKI; pfam01202 1072459014568 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1072459014569 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1072459014570 putative NAD(P) binding site [chemical binding]; other site 1072459014571 putative substrate binding site [chemical binding]; other site 1072459014572 catalytic Zn binding site [ion binding]; other site 1072459014573 structural Zn binding site [ion binding]; other site 1072459014574 dimer interface [polypeptide binding]; other site 1072459014575 integrase; Provisional; Region: PRK09692 1072459014576 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1072459014577 active site 1072459014578 Int/Topo IB signature motif; other site 1072459014579 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 1072459014580 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 1072459014581 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1072459014582 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1072459014583 DNA binding residues [nucleotide binding] 1072459014584 fec operon regulator FecR; Reviewed; Region: PRK09774 1072459014585 FecR protein; Region: FecR; pfam04773 1072459014586 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 1072459014587 Secretin and TonB N terminus short domain; Region: STN; smart00965 1072459014588 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1072459014589 N-terminal plug; other site 1072459014590 ligand-binding site [chemical binding]; other site 1072459014591 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 1072459014592 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1072459014593 siderophore binding site; other site 1072459014594 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1072459014595 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1072459014596 dimer interface [polypeptide binding]; other site 1072459014597 ABC-ATPase subunit interface; other site 1072459014598 putative PBP binding regions; other site 1072459014599 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1072459014600 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1072459014601 ABC-ATPase subunit interface; other site 1072459014602 dimer interface [polypeptide binding]; other site 1072459014603 putative PBP binding regions; other site 1072459014604 iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231 1072459014605 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1072459014606 Walker A/P-loop; other site 1072459014607 ATP binding site [chemical binding]; other site 1072459014608 Q-loop/lid; other site 1072459014609 ABC transporter signature motif; other site 1072459014610 Walker B; other site 1072459014611 D-loop; other site 1072459014612 H-loop/switch region; other site 1072459014613 CE10_5028; putative transposase B, IS911, fragment 1072459014614 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1072459014615 Transposase; Region: HTH_Tnp_1; cl17663 1072459014616 Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969 1072459014617 putative active site [active] 1072459014618 putative metal binding site [ion binding]; other site 1072459014619 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1072459014620 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1072459014621 Protein of unknown function (DUF535); Region: DUF535; pfam04393 1072459014622 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1072459014623 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1072459014624 putative acyl-acceptor binding pocket; other site 1072459014625 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1072459014626 Transposase; Region: HTH_Tnp_1; pfam01527 1072459014627 putative transposase OrfB; Reviewed; Region: PHA02517 1072459014628 Integrase core domain; Region: rve; pfam00665 1072459014629 Integrase core domain; Region: rve_3; pfam13683 1072459014630 BCCT family transporter; Region: BCCT; cl00569 1072459014631 putative transposase OrfB; Reviewed; Region: PHA02517 1072459014632 HTH-like domain; Region: HTH_21; pfam13276 1072459014633 Integrase core domain; Region: rve; pfam00665 1072459014634 Integrase core domain; Region: rve_3; pfam13683 1072459014635 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1072459014636 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1072459014637 Walker A motif; other site 1072459014638 ATP binding site [chemical binding]; other site 1072459014639 Walker B motif; other site 1072459014640 Protein kinase domain; Region: Pkinase; pfam00069 1072459014641 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1072459014642 active site 1072459014643 ATP binding site [chemical binding]; other site 1072459014644 substrate binding site [chemical binding]; other site 1072459014645 activation loop (A-loop); other site 1072459014646 HerA helicase [Replication, recombination, and repair]; Region: COG0433 1072459014647 Domain of unknown function DUF87; Region: DUF87; pfam01935 1072459014648 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 1072459014649 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1072459014650 McrBC 5-methylcytosine restriction system component; Region: McrBC; pfam10117 1072459014651 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 1072459014652 HNH endonuclease; Region: HNH_2; pfam13391 1072459014653 Domain of unknown function (DUF303); Region: DUF303; pfam03629 1072459014654 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 1072459014655 Kelch motif; Region: Kelch_1; pfam01344 1072459014656 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 1072459014657 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 1072459014658 Int/Topo IB signature motif; other site 1072459014659 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 1072459014660 Int/Topo IB signature motif; other site 1072459014661 Fimbrial protein; Region: Fimbrial; cl01416 1072459014662 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1072459014663 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 1072459014664 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1072459014665 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1072459014666 outer membrane usher protein; Provisional; Region: PRK15193 1072459014667 PapC N-terminal domain; Region: PapC_N; pfam13954 1072459014668 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1072459014669 PapC C-terminal domain; Region: PapC_C; pfam13953 1072459014670 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1072459014671 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1072459014672 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 1072459014673 mannosyl binding site [chemical binding]; other site 1072459014674 Fimbrial protein; Region: Fimbrial; pfam00419 1072459014675 fructuronate transporter; Provisional; Region: PRK10034 1072459014676 gluconate transporter; Region: gntP; TIGR00791 1072459014677 mannonate dehydratase; Region: uxuA; TIGR00695 1072459014678 mannonate dehydratase; Provisional; Region: PRK03906 1072459014679 D-mannonate oxidoreductase; Provisional; Region: PRK15037 1072459014680 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1072459014681 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1072459014682 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 1072459014683 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1072459014684 DNA-binding site [nucleotide binding]; DNA binding site 1072459014685 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1072459014686 Protein of unknown function (DUF2686); Region: DUF2686; pfam10887 1072459014687 cell density-dependent motility repressor; Provisional; Region: PRK10082 1072459014688 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1072459014689 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1072459014690 Isoaspartyl dipeptidase hydrolyzes the beta-L-isoaspartyl linkages in dipeptides, as part of the degradative pathway to eliminate proteins with beta-L-isoaspartyl peptide bonds, bonds whereby the beta-group of an aspartate forms the peptide link with the...; Region: Isoaspartyl-dipeptidase; cd01308 1072459014691 isoaspartyl dipeptidase IadA; Region: isoAsp_dipep; TIGR01975 1072459014692 dimer interface [polypeptide binding]; other site 1072459014693 active site 1072459014694 hypothetical protein; Provisional; Region: PRK10519 1072459014695 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 1072459014696 Nucleoside recognition; Region: Gate; pfam07670 1072459014697 SdiA-regulated; Region: SdiA-regulated; pfam06977 1072459014698 SdiA-regulated; Region: SdiA-regulated; cd09971 1072459014699 putative active site [active] 1072459014700 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 1072459014701 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 1072459014702 CoA-substrate-specific enzyme activase, putative; Region: CoA_E_activ; TIGR00241 1072459014703 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 1072459014704 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 1072459014705 Predicted membrane protein [Function unknown]; Region: COG2733 1072459014706 putative transposase; Provisional; Region: PRK09857 1072459014707 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1072459014708 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1072459014709 Protein of unknown function DUF262; Region: DUF262; pfam03235 1072459014710 Protein of unknown function DUF262; Region: DUF262; pfam03235 1072459014711 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1072459014712 Uncharacterized conserved protein [Function unknown]; Region: COG3586 1072459014713 endoribonuclease SymE; Provisional; Region: PRK13605 1072459014714 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1072459014715 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1072459014716 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1072459014717 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1072459014718 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1072459014719 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1072459014720 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 1072459014721 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 1072459014722 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1072459014723 ATP binding site [chemical binding]; other site 1072459014724 putative Mg++ binding site [ion binding]; other site 1072459014725 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1072459014726 Protein of unknown function DUF262; Region: DUF262; pfam03235 1072459014727 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1072459014728 Protein of unknown function DUF262; Region: DUF262; pfam03235 1072459014729 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1072459014730 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 1072459014731 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 1072459014732 P-loop, Walker A motif; other site 1072459014733 Base recognition motif; other site 1072459014734 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1072459014735 Uncharacterized small protein [Function unknown]; Region: COG2879 1072459014736 carbon starvation protein A; Provisional; Region: PRK15015 1072459014737 Carbon starvation protein CstA; Region: CstA; pfam02554 1072459014738 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1072459014739 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 1072459014740 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1072459014741 dimer interface [polypeptide binding]; other site 1072459014742 ligand binding site [chemical binding]; other site 1072459014743 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1072459014744 dimerization interface [polypeptide binding]; other site 1072459014745 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1072459014746 dimer interface [polypeptide binding]; other site 1072459014747 putative CheW interface [polypeptide binding]; other site 1072459014748 DctM-like transporters; Region: DctM; pfam06808 1072459014749 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1072459014750 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 1072459014751 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1072459014752 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1072459014753 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1072459014754 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1072459014755 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1072459014756 DNA-binding site [nucleotide binding]; DNA binding site 1072459014757 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1072459014758 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1072459014759 potential frameshift: common BLAST hit: gi|117626672|ref|YP_859995.1| oxidoreductase, Zn-dependent and NAD(P)-binding 1072459014760 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1072459014761 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1072459014762 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1072459014763 NAD(P) binding site [chemical binding]; other site 1072459014764 phosphoglycerol transferase I; Provisional; Region: PRK03776 1072459014765 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1072459014766 hypothetical protein; Provisional; Region: PRK11667 1072459014767 DNA replication protein DnaC; Validated; Region: PRK07952 1072459014768 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1072459014769 Walker A motif; other site 1072459014770 ATP binding site [chemical binding]; other site 1072459014771 Walker B motif; other site 1072459014772 primosomal protein DnaI; Provisional; Region: PRK02854 1072459014773 hypothetical protein; Provisional; Region: PRK09917 1072459014774 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1072459014775 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1072459014776 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1072459014777 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1072459014778 DNA binding residues [nucleotide binding] 1072459014779 dimerization interface [polypeptide binding]; other site 1072459014780 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 1072459014781 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1072459014782 DNA binding residues [nucleotide binding] 1072459014783 dimerization interface [polypeptide binding]; other site 1072459014784 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 1072459014785 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1072459014786 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1072459014787 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 1072459014788 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 1072459014789 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 1072459014790 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1072459014791 S-adenosylmethionine binding site [chemical binding]; other site 1072459014792 DNA polymerase III subunit psi; Validated; Region: PRK06856 1072459014793 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 1072459014794 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1072459014795 Coenzyme A binding pocket [chemical binding]; other site 1072459014796 dUMP phosphatase; Provisional; Region: PRK09449 1072459014797 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1072459014798 motif II; other site 1072459014799 integrase; Provisional; Region: PRK09692 1072459014800 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1072459014801 active site 1072459014802 Int/Topo IB signature motif; other site 1072459014803 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1072459014804 Active Sites [active] 1072459014805 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 1072459014806 Uncharacterized conserved protein (DUF2303); Region: DUF2303; cl02338 1072459014807 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1072459014808 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1072459014809 sequence-specific DNA binding site [nucleotide binding]; other site 1072459014810 salt bridge; other site 1072459014811 Predicted transcriptional regulator [Transcription]; Region: COG2932 1072459014812 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1072459014813 Catalytic site [active] 1072459014814 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1072459014815 non-specific DNA binding site [nucleotide binding]; other site 1072459014816 salt bridge; other site 1072459014817 sequence-specific DNA binding site [nucleotide binding]; other site 1072459014818 Ash protein family; Region: Phage_ASH; pfam10554 1072459014819 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 1072459014820 Helix-turn-helix domain; Region: HTH_36; pfam13730 1072459014821 PerC transcriptional activator; Region: PerC; pfam06069 1072459014822 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; pfam05869 1072459014823 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1072459014824 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 1072459014825 KilA-N domain; Region: KilA-N; pfam04383 1072459014826 Protein of unknown function (DUF968); Region: DUF968; pfam06147 1072459014827 Antitermination protein; Region: Antiterm; pfam03589 1072459014828 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 1072459014829 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1072459014830 Zn binding sites [ion binding]; other site 1072459014831 Antitermination protein; Region: Antiterm; pfam03589 1072459014832 EAP30/Vps36 family; Region: EAP30; pfam04157 1072459014833 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1072459014834 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1072459014835 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1072459014836 DNA methylase; Region: N6_N4_Mtase; pfam01555 1072459014837 Lysis protein S; Region: Lysis_S; pfam04971 1072459014838 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1072459014839 catalytic residues [active] 1072459014840 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 1072459014841 Protein of unknown function (DUF1441); Region: DUF1441; pfam07278 1072459014842 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 1072459014843 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1072459014844 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 1072459014845 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 1072459014846 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 1072459014847 Clp protease; Region: CLP_protease; pfam00574 1072459014848 oligomer interface [polypeptide binding]; other site 1072459014849 active site residues [active] 1072459014850 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 1072459014851 Uncharacterized conserved protein [Function unknown]; Region: COG5471 1072459014852 ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; pfam13856 1072459014853 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 1072459014854 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 1072459014855 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 1072459014856 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 1072459014857 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; cl06106 1072459014858 Minor tail protein T; Region: Phage_tail_T; pfam06223 1072459014859 Phage-related minor tail protein [Function unknown]; Region: COG5281 1072459014860 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 1072459014861 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 1072459014862 Phage-related protein [Function unknown]; Region: COG4718 1072459014863 Phage-related protein [Function unknown]; Region: gp18; COG4672 1072459014864 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 1072459014865 MPN+ (JAMM) motif; other site 1072459014866 Zinc-binding site [ion binding]; other site 1072459014867 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1072459014868 NlpC/P60 family; Region: NLPC_P60; cl17555 1072459014869 Phage-related protein, tail component [Function unknown]; Region: COG4723 1072459014870 Phage-related protein, tail component [Function unknown]; Region: COG4733 1072459014871 Putative phage tail protein; Region: Phage-tail_3; pfam13550 1072459014872 Fibronectin type 3 domain; Region: FN3; smart00060 1072459014873 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 1072459014874 Fibronectin type III protein; Region: DUF3672; pfam12421 1072459014875 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 1072459014876 Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated...; Region: PTX; cl00102 1072459014877 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 1072459014878 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 1072459014879 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1072459014880 active site 1072459014881 NTP binding site [chemical binding]; other site 1072459014882 nucleic acid binding site [nucleotide binding]; other site 1072459014883 DinI-like family; Region: DinI; pfam06183 1072459014884 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1072459014885 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1072459014886 G1 box; other site 1072459014887 putative GEF interaction site [polypeptide binding]; other site 1072459014888 GTP/Mg2+ binding site [chemical binding]; other site 1072459014889 Switch I region; other site 1072459014890 G2 box; other site 1072459014891 G3 box; other site 1072459014892 Switch II region; other site 1072459014893 G4 box; other site 1072459014894 G5 box; other site 1072459014895 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1072459014896 periplasmic protein; Provisional; Region: PRK10568 1072459014897 BON domain; Region: BON; pfam04972 1072459014898 BON domain; Region: BON; pfam04972 1072459014899 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 1072459014900 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 1072459014901 active site 1072459014902 nucleophile elbow; other site 1072459014903 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1072459014904 active site 1072459014905 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 1072459014906 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1072459014907 FeS/SAM binding site; other site 1072459014908 hypothetical protein; Provisional; Region: PRK10977 1072459014909 hypothetical protein; Provisional; Region: PRK10977 1072459014910 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1072459014911 intersubunit interface [polypeptide binding]; other site 1072459014912 active site 1072459014913 catalytic residue [active] 1072459014914 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 1072459014915 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1072459014916 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1072459014917 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1072459014918 phosphopentomutase; Provisional; Region: PRK05362 1072459014919 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1072459014920 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1072459014921 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1072459014922 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1072459014923 non-specific DNA binding site [nucleotide binding]; other site 1072459014924 salt bridge; other site 1072459014925 sequence-specific DNA binding site [nucleotide binding]; other site 1072459014926 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 1072459014927 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1072459014928 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1072459014929 hypothetical protein; Provisional; Region: PRK11246 1072459014930 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 1072459014931 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1072459014932 motif II; other site 1072459014933 DNA repair protein RadA; Region: sms; TIGR00416 1072459014934 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1072459014935 Walker A motif/ATP binding site; other site 1072459014936 ATP binding site [chemical binding]; other site 1072459014937 Walker B motif; other site 1072459014938 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1072459014939 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1072459014940 non-specific DNA binding site [nucleotide binding]; other site 1072459014941 salt bridge; other site 1072459014942 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 1072459014943 sequence-specific DNA binding site [nucleotide binding]; other site 1072459014944 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 1072459014945 active site 1072459014946 (T/H)XGH motif; other site 1072459014947 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 1072459014948 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1072459014949 non-specific DNA binding site [nucleotide binding]; other site 1072459014950 salt bridge; other site 1072459014951 sequence-specific DNA binding site [nucleotide binding]; other site 1072459014952 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1072459014953 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1072459014954 Walker A/P-loop; other site 1072459014955 ATP binding site [chemical binding]; other site 1072459014956 Q-loop/lid; other site 1072459014957 ABC transporter signature motif; other site 1072459014958 Walker B; other site 1072459014959 D-loop; other site 1072459014960 H-loop/switch region; other site 1072459014961 ABC transporter; Region: ABC_tran_2; pfam12848 1072459014962 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1072459014963 lytic murein transglycosylase; Provisional; Region: PRK11619 1072459014964 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1072459014965 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1072459014966 catalytic residue [active] 1072459014967 Trp operon repressor; Provisional; Region: PRK01381 1072459014968 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 1072459014969 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1072459014970 catalytic core [active] 1072459014971 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 1072459014972 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1072459014973 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 1072459014974 hypothetical protein; Provisional; Region: PRK10756 1072459014975 CreA protein; Region: CreA; pfam05981 1072459014976 DNA-binding response regulator CreB; Provisional; Region: PRK11083 1072459014977 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1072459014978 active site 1072459014979 phosphorylation site [posttranslational modification] 1072459014980 intermolecular recognition site; other site 1072459014981 dimerization interface [polypeptide binding]; other site 1072459014982 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1072459014983 DNA binding site [nucleotide binding] 1072459014984 sensory histidine kinase CreC; Provisional; Region: PRK11100 1072459014985 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1072459014986 dimerization interface [polypeptide binding]; other site 1072459014987 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1072459014988 dimer interface [polypeptide binding]; other site 1072459014989 phosphorylation site [posttranslational modification] 1072459014990 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1072459014991 ATP binding site [chemical binding]; other site 1072459014992 Mg2+ binding site [ion binding]; other site 1072459014993 G-X-G motif; other site 1072459014994 Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452 1072459014995 two-component response regulator; Provisional; Region: PRK11173 1072459014996 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1072459014997 active site 1072459014998 phosphorylation site [posttranslational modification] 1072459014999 intermolecular recognition site; other site 1072459015000 dimerization interface [polypeptide binding]; other site 1072459015001 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1072459015002 DNA binding site [nucleotide binding] 1072459015003 putative RNA methyltransferase; Provisional; Region: PRK10433 1072459015004 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050 1072459015005 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 1072459015006 replication protein; Provisional; Region: PRK13702 1072459015007 replication protein; Provisional; Region: PRK13750 1072459015008 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1072459015009 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1072459015010 Integrase core domain; Region: rve; pfam00665 1072459015011 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1072459015012 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1072459015013 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1072459015014 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 1072459015015 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1072459015016 catalytic residues [active] 1072459015017 Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346 1072459015018 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 1072459015019 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 1072459015020 Uncharacterized protein probably involved in high-affinity Fe2+ transport [Inorganic ion transport and metabolism]; Region: Tpd; COG3470 1072459015021 Predicted membrane protein [Function unknown]; Region: COG4393 1072459015022 Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080 1072459015023 Uncharacterized conserved protein [Function unknown]; Region: COG3350 1072459015024 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1072459015025 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1072459015026 FtsX-like permease family; Region: FtsX; pfam02687 1072459015027 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1072459015028 FtsX-like permease family; Region: FtsX; pfam02687 1072459015029 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1072459015030 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1072459015031 Walker A/P-loop; other site 1072459015032 ATP binding site [chemical binding]; other site 1072459015033 Q-loop/lid; other site 1072459015034 ABC transporter signature motif; other site 1072459015035 Walker B; other site 1072459015036 D-loop; other site 1072459015037 H-loop/switch region; other site 1072459015038 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1072459015039 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1072459015040 catalytic residues [active] 1072459015041 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1072459015042 catalytic core [active] 1072459015043 potential frameshift: common BLAST hit: gi|378979731|ref|YP_005227872.1| putative transposase 1072459015044 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1072459015045 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1072459015046 Transposase domain (DUF772); Region: DUF772; pfam05598 1072459015047 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1072459015048 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1072459015049 putative transposase OrfB; Reviewed; Region: PHA02517 1072459015050 HTH-like domain; Region: HTH_21; pfam13276 1072459015051 Integrase core domain; Region: rve; pfam00665 1072459015052 Integrase core domain; Region: rve_3; pfam13683 1072459015053 Transposase; Region: HTH_Tnp_1; cl17663 1072459015054 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1072459015055 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1072459015056 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 1072459015057 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1072459015058 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1072459015059 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 1072459015060 Protein of unknown function, DUF399; Region: DUF399; pfam04187 1072459015061 Replicase family; Region: Replicase; pfam03090 1072459015062 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708 1072459015063 Colicin E1 (microcin) immunity protein; Region: Microcin; pfam03526 1072459015064 HTH-like domain; Region: HTH_21; pfam13276 1072459015065 Integrase core domain; Region: rve; pfam00665 1072459015066 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1072459015067 Integrase core domain; Region: rve_3; pfam13683 1072459015068 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1072459015069 Transposase; Region: HTH_Tnp_1; cl17663 1072459015070 Transposase; Region: HTH_Tnp_1; cl17663 1072459015071 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1072459015072 putative transposase OrfB; Reviewed; Region: PHA02517 1072459015073 HTH-like domain; Region: HTH_21; pfam13276 1072459015074 Integrase core domain; Region: rve; pfam00665 1072459015075 Integrase core domain; Region: rve_3; pfam13683 1072459015076 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 1072459015077 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1072459015078 N-terminal plug; other site 1072459015079 ligand-binding site [chemical binding]; other site 1072459015080 IS2 repressor TnpA; Reviewed; Region: PRK09413 1072459015081 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1072459015082 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1072459015083 active site 1072459015084 catalytic residues [active] 1072459015085 DNA binding site [nucleotide binding] 1072459015086 Int/Topo IB signature motif; other site 1072459015087 plasmid maintenance protein CcdA; Provisional; Region: PRK13710 1072459015088 plasmid maintenance protein CcdB; Provisional; Region: PRK13708 1072459015089 Phage integrase family; Region: Phage_integrase; pfam00589 1072459015090 active site 1072459015091 DNA binding site [nucleotide binding] 1072459015092 Int/Topo IB signature motif; other site 1072459015093 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 1072459015094 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1072459015095 ParA-like protein; Provisional; Region: PHA02518 1072459015096 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1072459015097 P-loop; other site 1072459015098 Magnesium ion binding site [ion binding]; other site 1072459015099 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 1072459015100 Mg binding site [ion binding]; other site 1072459015101 nucleotide binding site [chemical binding]; other site 1072459015102 putative protofilament interface [polypeptide binding]; other site 1072459015103 Plasmid stability protein; Region: Plasmid_stab_B; pfam10784 1072459015104 putative transposase OrfB; Reviewed; Region: PHA02517 1072459015105 HTH-like domain; Region: HTH_21; pfam13276 1072459015106 Integrase core domain; Region: rve; pfam00665 1072459015107 Integrase core domain; Region: rve_3; pfam13683 1072459015108 Transposase; Region: HTH_Tnp_1; cl17663 1072459015109 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1072459015110 conjugal transfer nickase/helicase TraI; Provisional; Region: PRK14712 1072459015111 conjugal transfer pilus acetylation protein TraX; Provisional; Region: PRK13706 1072459015112 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1072459015113 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1072459015114 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1072459015115 conjugal transfer fertility inhibition protein FinO; Provisional; Region: PRK13754 1072459015116 Fertility inhibition protein N terminal; Region: FinO_N; pfam12602 1072459015117 FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cd00236 1072459015118 putative RNA binding sites [nucleotide binding]; other site 1072459015119 Transposase; Region: HTH_Tnp_1; cl17663 1072459015120 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1072459015121 putative transposase OrfB; Reviewed; Region: PHA02517 1072459015122 HTH-like domain; Region: HTH_21; pfam13276 1072459015123 Integrase core domain; Region: rve; pfam00665 1072459015124 Integrase core domain; Region: rve_3; pfam13683 1072459015125 Staphylococcal nuclease homologues; Region: SNc; smart00318 1072459015126 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1072459015127 Catalytic site; other site 1072459015128 Haemolysin expression modulating protein; Region: HHA; pfam05321 1072459015129 Replicase family; Region: Replicase; pfam03090 1072459015130 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708 1072459015131 MobA/MobL family; Region: MobA_MobL; pfam03389 1072459015132 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1072459015133 non-specific DNA binding site [nucleotide binding]; other site 1072459015134 salt bridge; other site 1072459015135 sequence-specific DNA binding site [nucleotide binding]; other site 1072459015136 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1072459015137 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 1072459015138 cofactor binding site; other site 1072459015139 DNA binding site [nucleotide binding] 1072459015140 substrate interaction site [chemical binding]; other site 1072459015141 EcoRII C terminal; Region: EcoRII-C; pfam09019 1072459015142 Helix-turn-helix domain; Region: HTH_36; pfam13730