-- dump date 20140619_090425 -- class Genbank::misc_feature -- table misc_feature_note -- id note 685038000001 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 685038000002 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 685038000003 putative catalytic residues [active] 685038000004 putative nucleotide binding site [chemical binding]; other site 685038000005 putative aspartate binding site [chemical binding]; other site 685038000006 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 685038000007 dimer interface [polypeptide binding]; other site 685038000008 putative threonine allosteric regulatory site; other site 685038000009 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 685038000010 putative threonine allosteric regulatory site; other site 685038000011 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 685038000012 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 685038000013 homoserine kinase; Region: thrB; TIGR00191 685038000014 Protein of unknown function; Region: YhfT; pfam10797 685038000015 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 685038000016 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 685038000017 threonine synthase; Validated; Region: PRK09225 685038000018 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 685038000019 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685038000020 catalytic residue [active] 685038000021 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 685038000022 hypothetical protein; Validated; Region: PRK02101 685038000023 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 685038000024 transaldolase-like protein; Provisional; Region: PTZ00411 685038000025 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 685038000026 active site 685038000027 dimer interface [polypeptide binding]; other site 685038000028 catalytic residue [active] 685038000029 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 685038000030 MPT binding site; other site 685038000031 trimer interface [polypeptide binding]; other site 685038000032 hypothetical protein; Provisional; Region: PRK10659 685038000033 hypothetical protein; Provisional; Region: PRK10236 685038000034 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 685038000035 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 685038000036 hypothetical protein; Provisional; Region: PRK10154 685038000037 potential protein location (hypothetical protein) that overlaps protein (molecular chaperone DnaK) 685038000038 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 685038000039 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 685038000040 nucleotide binding site [chemical binding]; other site 685038000041 NEF interaction site [polypeptide binding]; other site 685038000042 SBD interface [polypeptide binding]; other site 685038000043 chaperone protein DnaJ; Provisional; Region: PRK10767 685038000044 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 685038000045 HSP70 interaction site [polypeptide binding]; other site 685038000046 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 685038000047 substrate binding site [polypeptide binding]; other site 685038000048 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 685038000049 Zn binding sites [ion binding]; other site 685038000050 dimer interface [polypeptide binding]; other site 685038000051 Hok/gef family; Region: HOK_GEF; pfam01848 685038000052 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; pfam03502 685038000053 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 685038000054 Sulfatase; Region: Sulfatase; pfam00884 685038000055 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 685038000056 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 685038000057 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685038000058 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 685038000059 putative dimerization interface [polypeptide binding]; other site 685038000060 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 685038000061 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 685038000062 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 685038000063 active site 685038000064 Riboflavin kinase; Region: Flavokinase; smart00904 685038000065 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 685038000066 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 685038000067 active site 685038000068 HIGH motif; other site 685038000069 KMSKS motif; other site 685038000070 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 685038000071 tRNA binding surface [nucleotide binding]; other site 685038000072 anticodon binding site; other site 685038000073 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 685038000074 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 685038000075 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 685038000076 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 685038000077 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944 685038000078 Fe-S cluster binding site [ion binding]; other site 685038000079 substrate binding site [chemical binding]; other site 685038000080 catalytic site [active] 685038000081 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 685038000082 active site 685038000083 tetramer interface [polypeptide binding]; other site 685038000084 Protein of unknown function (DUF805); Region: DUF805; pfam05656 685038000085 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 685038000086 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 685038000087 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 685038000088 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 685038000089 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 685038000090 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 685038000091 catalytic site [active] 685038000092 subunit interface [polypeptide binding]; other site 685038000093 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 685038000094 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 685038000095 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 685038000096 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 685038000097 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 685038000098 ATP-grasp domain; Region: ATP-grasp_4; cl17255 685038000099 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 685038000100 IMP binding site; other site 685038000101 dimer interface [polypeptide binding]; other site 685038000102 interdomain contacts; other site 685038000103 partial ornithine binding site; other site 685038000104 DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476 685038000105 carnitine operon protein CaiE; Provisional; Region: PRK13627 685038000106 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 685038000107 putative trimer interface [polypeptide binding]; other site 685038000108 putative metal binding site [ion binding]; other site 685038000109 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 685038000110 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 685038000111 substrate binding site [chemical binding]; other site 685038000112 oxyanion hole (OAH) forming residues; other site 685038000113 trimer interface [polypeptide binding]; other site 685038000114 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 685038000115 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 685038000116 acyl-activating enzyme (AAE) consensus motif; other site 685038000117 putative AMP binding site [chemical binding]; other site 685038000118 putative active site [active] 685038000119 putative CoA binding site [chemical binding]; other site 685038000120 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 685038000121 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 685038000122 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 685038000123 active site 685038000124 L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356 685038000125 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 685038000126 Ligand binding site [chemical binding]; other site 685038000127 putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363 685038000128 Electron transfer flavoprotein domain; Region: ETF; pfam01012 685038000129 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 685038000130 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 685038000131 putative oxidoreductase FixC; Provisional; Region: PRK10157 685038000132 ferredoxin-like protein FixX; Provisional; Region: PRK15449 685038000133 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038000134 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 685038000135 putative substrate translocation pore; other site 685038000136 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 685038000137 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 685038000138 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 685038000139 TrkA-N domain; Region: TrkA_N; pfam02254 685038000140 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 685038000141 folate binding site [chemical binding]; other site 685038000142 NADP+ binding site [chemical binding]; other site 685038000143 Post-segregation antitoxin CcdA; Region: CcdA; pfam07362 685038000144 CcdB protein; Region: CcdB; pfam01845 685038000145 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 685038000146 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 685038000147 active site 685038000148 metal binding site [ion binding]; metal-binding site 685038000149 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 685038000150 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 685038000151 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 685038000152 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 685038000153 SurA N-terminal domain; Region: SurA_N; pfam09312 685038000154 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 685038000155 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 685038000156 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 685038000157 OstA-like protein; Region: OstA; pfam03968 685038000158 Organic solvent tolerance protein; Region: OstA_C; pfam04453 685038000159 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 685038000160 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 685038000161 putative metal binding site [ion binding]; other site 685038000162 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 685038000163 HSP70 interaction site [polypeptide binding]; other site 685038000164 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 685038000165 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 685038000166 active site 685038000167 ATP-dependent helicase HepA; Validated; Region: PRK04914 685038000168 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 685038000169 ATP binding site [chemical binding]; other site 685038000170 putative Mg++ binding site [ion binding]; other site 685038000171 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 685038000172 nucleotide binding region [chemical binding]; other site 685038000173 ATP-binding site [chemical binding]; other site 685038000174 RNA polymerase recycling family C-terminal; Region: RapA_C; pfam12137 685038000175 DNA polymerase II; Reviewed; Region: PRK05762 685038000176 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 685038000177 active site 685038000178 catalytic site [active] 685038000179 substrate binding site [chemical binding]; other site 685038000180 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 685038000181 active site 685038000182 metal-binding site 685038000183 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 685038000184 intersubunit interface [polypeptide binding]; other site 685038000185 active site 685038000186 Zn2+ binding site [ion binding]; other site 685038000187 L-arabinose isomerase; Provisional; Region: PRK02929 685038000188 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 685038000189 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 685038000190 trimer interface [polypeptide binding]; other site 685038000191 putative substrate binding site [chemical binding]; other site 685038000192 putative metal binding site [ion binding]; other site 685038000193 ribulokinase; Provisional; Region: PRK04123 685038000194 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 685038000195 N- and C-terminal domain interface [polypeptide binding]; other site 685038000196 active site 685038000197 MgATP binding site [chemical binding]; other site 685038000198 catalytic site [active] 685038000199 metal binding site [ion binding]; metal-binding site 685038000200 carbohydrate binding site [chemical binding]; other site 685038000201 homodimer interface [polypeptide binding]; other site 685038000202 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 685038000203 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 685038000204 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 685038000205 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 685038000206 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 685038000207 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 685038000208 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 685038000209 Walker A/P-loop; other site 685038000210 ATP binding site [chemical binding]; other site 685038000211 Q-loop/lid; other site 685038000212 ABC transporter signature motif; other site 685038000213 Walker B; other site 685038000214 D-loop; other site 685038000215 H-loop/switch region; other site 685038000216 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 685038000217 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685038000218 dimer interface [polypeptide binding]; other site 685038000219 conserved gate region; other site 685038000220 putative PBP binding loops; other site 685038000221 ABC-ATPase subunit interface; other site 685038000222 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685038000223 dimer interface [polypeptide binding]; other site 685038000224 conserved gate region; other site 685038000225 putative PBP binding loops; other site 685038000226 ABC-ATPase subunit interface; other site 685038000227 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 685038000228 transcriptional regulator SgrR; Provisional; Region: PRK13626 685038000229 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 685038000230 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 685038000231 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 685038000232 substrate binding site [chemical binding]; other site 685038000233 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 685038000234 substrate binding site [chemical binding]; other site 685038000235 ligand binding site [chemical binding]; other site 685038000236 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 685038000237 2-isopropylmalate synthase; Validated; Region: PRK00915 685038000238 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 685038000239 active site 685038000240 catalytic residues [active] 685038000241 metal binding site [ion binding]; metal-binding site 685038000242 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 685038000243 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 685038000244 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685038000245 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 685038000246 putative substrate binding pocket [chemical binding]; other site 685038000247 putative dimerization interface [polypeptide binding]; other site 685038000248 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 685038000249 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 685038000250 PYR/PP interface [polypeptide binding]; other site 685038000251 dimer interface [polypeptide binding]; other site 685038000252 TPP binding site [chemical binding]; other site 685038000253 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 685038000254 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 685038000255 TPP-binding site [chemical binding]; other site 685038000256 dimer interface [polypeptide binding]; other site 685038000257 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 685038000258 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 685038000259 putative valine binding site [chemical binding]; other site 685038000260 dimer interface [polypeptide binding]; other site 685038000261 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 685038000262 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 685038000263 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 685038000264 DNA binding site [nucleotide binding] 685038000265 domain linker motif; other site 685038000266 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 685038000267 dimerization interface [polypeptide binding]; other site 685038000268 ligand binding site [chemical binding]; other site 685038000269 mraZ protein; Region: TIGR00242 685038000270 MraZ protein; Region: MraZ; pfam02381 685038000271 MraZ protein; Region: MraZ; pfam02381 685038000272 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 685038000273 cell division protein FtsL; Provisional; Region: PRK10772 685038000274 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 685038000275 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 685038000276 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 685038000277 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 685038000278 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 685038000279 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 685038000280 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 685038000281 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 685038000282 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 685038000283 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 685038000284 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 685038000285 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 685038000286 Mg++ binding site [ion binding]; other site 685038000287 putative catalytic motif [active] 685038000288 putative substrate binding site [chemical binding]; other site 685038000289 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 685038000290 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 685038000291 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 685038000292 cell division protein FtsW; Provisional; Region: PRK10774 685038000293 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 685038000294 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 685038000295 active site 685038000296 homodimer interface [polypeptide binding]; other site 685038000297 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 685038000298 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 685038000299 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 685038000300 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 685038000301 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 685038000302 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 685038000303 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 685038000304 cell division protein FtsQ; Provisional; Region: PRK10775 685038000305 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 685038000306 Cell division protein FtsQ; Region: FtsQ; pfam03799 685038000307 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 685038000308 Cell division protein FtsA; Region: FtsA; pfam14450 685038000309 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 685038000310 Cell division protein FtsA; Region: FtsA; pfam14450 685038000311 cell division protein FtsZ; Validated; Region: PRK09330 685038000312 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 685038000313 nucleotide binding site [chemical binding]; other site 685038000314 SulA interaction site; other site 685038000315 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 685038000316 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 685038000317 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 685038000318 SecA regulator SecM; Provisional; Region: PRK02943 685038000319 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 685038000320 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 685038000321 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 685038000322 SEC-C motif; Region: SEC-C; pfam02810 685038000323 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 685038000324 active site 685038000325 8-oxo-dGMP binding site [chemical binding]; other site 685038000326 nudix motif; other site 685038000327 metal binding site [ion binding]; metal-binding site 685038000328 DNA gyrase inhibitor; Reviewed; Region: PRK00418 685038000329 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 685038000330 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 685038000331 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 685038000332 CoA-binding site [chemical binding]; other site 685038000333 ATP-binding [chemical binding]; other site 685038000334 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 685038000335 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 685038000336 active site 685038000337 type IV pilin biogenesis protein; Provisional; Region: PRK10573 685038000338 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 685038000339 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 685038000340 hypothetical protein; Provisional; Region: PRK10436 685038000341 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 685038000342 Walker A motif; other site 685038000343 ATP binding site [chemical binding]; other site 685038000344 Walker B motif; other site 685038000345 putative major pilin subunit; Provisional; Region: PRK10574 685038000346 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 685038000347 Pilin (bacterial filament); Region: Pilin; pfam00114 685038000348 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 685038000349 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 685038000350 dimerization interface [polypeptide binding]; other site 685038000351 active site 685038000352 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 685038000353 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 685038000354 amidase catalytic site [active] 685038000355 Zn binding residues [ion binding]; other site 685038000356 substrate binding site [chemical binding]; other site 685038000357 regulatory protein AmpE; Provisional; Region: PRK10987 685038000358 aromatic amino acid transporter; Provisional; Region: PRK10238 685038000359 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 685038000360 Protein of unknown function (DUF796); Region: DUF796; cl01226 685038000361 S-type Pyocin; Region: Pyocin_S; pfam06958 685038000362 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; pfam12639 685038000363 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 685038000364 active site 685038000365 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 685038000366 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 685038000367 active site 685038000368 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 685038000369 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 685038000370 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 685038000371 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 685038000372 DNA-binding site [nucleotide binding]; DNA binding site 685038000373 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 685038000374 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 685038000375 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 685038000376 dimer interface [polypeptide binding]; other site 685038000377 TPP-binding site [chemical binding]; other site 685038000378 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 685038000379 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 685038000380 E3 interaction surface; other site 685038000381 lipoyl attachment site [posttranslational modification]; other site 685038000382 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 685038000383 E3 interaction surface; other site 685038000384 lipoyl attachment site [posttranslational modification]; other site 685038000385 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 685038000386 E3 interaction surface; other site 685038000387 lipoyl attachment site [posttranslational modification]; other site 685038000388 e3 binding domain; Region: E3_binding; pfam02817 685038000389 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 685038000390 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 685038000391 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 685038000392 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 685038000393 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 685038000394 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 685038000395 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 685038000396 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 685038000397 Aconitate B N-terminal domain; Region: Aconitase_B_N; pfam11791 685038000398 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 685038000399 substrate binding site [chemical binding]; other site 685038000400 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 685038000401 substrate binding site [chemical binding]; other site 685038000402 ligand binding site [chemical binding]; other site 685038000403 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3112 685038000404 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 685038000405 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685038000406 S-adenosylmethionine binding site [chemical binding]; other site 685038000407 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 685038000408 multicopper oxidase; Provisional; Region: PRK10965 685038000409 The first Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_1_CueO_FtsP; cd04232 685038000410 Domain 2 interface [polypeptide binding]; other site 685038000411 Domain 3 interface [polypeptide binding]; other site 685038000412 trinuclear Cu binding site [ion binding]; other site 685038000413 The second Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_2_CueO_FtsP; cd13867 685038000414 Domain 1 interface [polypeptide binding]; other site 685038000415 Domain 3 interface [polypeptide binding]; other site 685038000416 The third Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_3_CueO_FtsP; cd13890 685038000417 Domain 2 interface [polypeptide binding]; other site 685038000418 Domain 1 interface [polypeptide binding]; other site 685038000419 Type 1 (T1) Cu binding site [ion binding]; other site 685038000420 trinuclear Cu binding site [ion binding]; other site 685038000421 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 685038000422 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 685038000423 Trp docking motif [polypeptide binding]; other site 685038000424 putative active site [active] 685038000425 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 685038000426 active site 685038000427 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 685038000428 active site clefts [active] 685038000429 zinc binding site [ion binding]; other site 685038000430 dimer interface [polypeptide binding]; other site 685038000431 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 685038000432 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 685038000433 Walker A/P-loop; other site 685038000434 ATP binding site [chemical binding]; other site 685038000435 Q-loop/lid; other site 685038000436 ABC transporter signature motif; other site 685038000437 Walker B; other site 685038000438 D-loop; other site 685038000439 H-loop/switch region; other site 685038000440 inner membrane transport permease; Provisional; Region: PRK15066 685038000441 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 685038000442 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 685038000443 active pocket/dimerization site; other site 685038000444 active site 685038000445 phosphorylation site [posttranslational modification] 685038000446 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 685038000447 putative active site [active] 685038000448 putative metal binding site [ion binding]; other site 685038000449 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 685038000450 tetramerization interface [polypeptide binding]; other site 685038000451 active site 685038000452 Uncharacterized conserved protein [Function unknown]; Region: COG5464 685038000453 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 685038000454 Pantoate-beta-alanine ligase; Region: PanC; cd00560 685038000455 active site 685038000456 ATP-binding site [chemical binding]; other site 685038000457 pantoate-binding site; other site 685038000458 HXXH motif; other site 685038000459 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 685038000460 oligomerization interface [polypeptide binding]; other site 685038000461 active site 685038000462 metal binding site [ion binding]; metal-binding site 685038000463 putative fimbrial-like adhesin protein; Provisional; Region: PRK09723 685038000464 putative fimbrial protein StaF; Provisional; Region: PRK15262 685038000465 putative fimbrial protein StaE; Provisional; Region: PRK15263 685038000466 Fimbrial protein; Region: Fimbrial; cl01416 685038000467 putative fimbrial outer membrane usher protein; Provisional; Region: PRK09828 685038000468 PapC N-terminal domain; Region: PapC_N; pfam13954 685038000469 Outer membrane usher protein; Region: Usher; pfam00577 685038000470 PapC C-terminal domain; Region: PapC_C; pfam13953 685038000471 putative chaperone protein EcpD; Provisional; Region: PRK09926 685038000472 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 685038000473 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 685038000474 Fimbrial protein; Region: Fimbrial; cl01416 685038000475 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 685038000476 catalytic center binding site [active] 685038000477 ATP binding site [chemical binding]; other site 685038000478 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 685038000479 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 685038000480 active site 685038000481 NTP binding site [chemical binding]; other site 685038000482 metal binding triad [ion binding]; metal-binding site 685038000483 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 685038000484 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 685038000485 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 685038000486 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 685038000487 active site 685038000488 nucleotide binding site [chemical binding]; other site 685038000489 HIGH motif; other site 685038000490 KMSKS motif; other site 685038000491 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 685038000492 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 685038000493 2'-5' RNA ligase; Provisional; Region: PRK15124 685038000494 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 685038000495 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 685038000496 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 685038000497 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 685038000498 ATP binding site [chemical binding]; other site 685038000499 putative Mg++ binding site [ion binding]; other site 685038000500 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 685038000501 nucleotide binding region [chemical binding]; other site 685038000502 ATP-binding site [chemical binding]; other site 685038000503 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 685038000504 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 685038000505 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 685038000506 Transmembrane domain of transglycosylase PBP1 at N-terminal; Region: PBP1_TM; pfam14812 685038000507 Bifunctional transglycosylase second domain; Region: UB2H; pfam14814 685038000508 Transglycosylase; Region: Transgly; pfam00912 685038000509 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 685038000510 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 685038000511 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 685038000512 N-terminal plug; other site 685038000513 ligand-binding site [chemical binding]; other site 685038000514 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 685038000515 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 685038000516 Walker A/P-loop; other site 685038000517 ATP binding site [chemical binding]; other site 685038000518 Q-loop/lid; other site 685038000519 ABC transporter signature motif; other site 685038000520 Walker B; other site 685038000521 D-loop; other site 685038000522 H-loop/switch region; other site 685038000523 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 685038000524 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 685038000525 siderophore binding site; other site 685038000526 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 685038000527 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 685038000528 ABC-ATPase subunit interface; other site 685038000529 dimer interface [polypeptide binding]; other site 685038000530 putative PBP binding regions; other site 685038000531 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 685038000532 ABC-ATPase subunit interface; other site 685038000533 dimer interface [polypeptide binding]; other site 685038000534 putative PBP binding regions; other site 685038000535 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 685038000536 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 685038000537 inhibitor-cofactor binding pocket; inhibition site 685038000538 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685038000539 catalytic residue [active] 685038000540 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 685038000541 Cl- selectivity filter; other site 685038000542 Cl- binding residues [ion binding]; other site 685038000543 pore gating glutamate residue; other site 685038000544 dimer interface [polypeptide binding]; other site 685038000545 H+/Cl- coupling transport residue; other site 685038000546 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 685038000547 hypothetical protein; Provisional; Region: PRK10578 685038000548 UPF0126 domain; Region: UPF0126; pfam03458 685038000549 UPF0126 domain; Region: UPF0126; pfam03458 685038000550 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 685038000551 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 685038000552 cobalamin binding residues [chemical binding]; other site 685038000553 putative BtuC binding residues; other site 685038000554 dimer interface [polypeptide binding]; other site 685038000555 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 685038000556 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 685038000557 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 685038000558 Zn2+ binding site [ion binding]; other site 685038000559 Mg2+ binding site [ion binding]; other site 685038000560 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 685038000561 serine endoprotease; Provisional; Region: PRK10942 685038000562 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 685038000563 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 685038000564 protein binding site [polypeptide binding]; other site 685038000565 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 685038000566 protein binding site [polypeptide binding]; other site 685038000567 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 685038000568 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 685038000569 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 685038000570 hypothetical protein; Provisional; Region: PRK13677 685038000571 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 685038000572 Tetrahydrodipicolinate N-succinyltransferase N-terminal; Region: THDPS_N_2; pfam14805 685038000573 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 685038000574 trimer interface [polypeptide binding]; other site 685038000575 active site 685038000576 substrate binding site [chemical binding]; other site 685038000577 CoA binding site [chemical binding]; other site 685038000578 PII uridylyl-transferase; Provisional; Region: PRK05007 685038000579 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 685038000580 metal binding triad; other site 685038000581 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 685038000582 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 685038000583 Zn2+ binding site [ion binding]; other site 685038000584 Mg2+ binding site [ion binding]; other site 685038000585 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 685038000586 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 685038000587 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 685038000588 active site 685038000589 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 685038000590 rRNA interaction site [nucleotide binding]; other site 685038000591 S8 interaction site; other site 685038000592 putative laminin-1 binding site; other site 685038000593 elongation factor Ts; Provisional; Region: tsf; PRK09377 685038000594 UBA/TS-N domain; Region: UBA; pfam00627 685038000595 Bacterial virulence factor haemolysin; Region: SMP_2; cl11479 685038000596 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 685038000597 putative nucleotide binding site [chemical binding]; other site 685038000598 uridine monophosphate binding site [chemical binding]; other site 685038000599 homohexameric interface [polypeptide binding]; other site 685038000600 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 685038000601 hinge region; other site 685038000602 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: Dxr; TIGR00243 685038000603 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 685038000604 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 685038000605 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 685038000606 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 685038000607 active site 685038000608 dimer interface [polypeptide binding]; other site 685038000609 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 685038000610 zinc metallopeptidase RseP; Provisional; Region: PRK10779 685038000611 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 685038000612 active site 685038000613 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 685038000614 protein binding site [polypeptide binding]; other site 685038000615 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 685038000616 protein binding site [polypeptide binding]; other site 685038000617 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 685038000618 putative substrate binding region [chemical binding]; other site 685038000619 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 685038000620 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 685038000621 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 685038000622 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 685038000623 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 685038000624 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 685038000625 Surface antigen; Region: Bac_surface_Ag; pfam01103 685038000626 periplasmic chaperone; Provisional; Region: PRK10780 685038000627 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 685038000628 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 685038000629 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 685038000630 trimer interface [polypeptide binding]; other site 685038000631 active site 685038000632 UDP-GlcNAc binding site [chemical binding]; other site 685038000633 lipid binding site [chemical binding]; lipid-binding site 685038000634 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 685038000635 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 685038000636 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 685038000637 active site 685038000638 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 685038000639 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 685038000640 Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 685038000641 RNA/DNA hybrid binding site [nucleotide binding]; other site 685038000642 active site 685038000643 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 685038000644 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 685038000645 putative active site [active] 685038000646 putative PHP Thumb interface [polypeptide binding]; other site 685038000647 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 685038000648 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 685038000649 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 685038000650 generic binding surface II; other site 685038000651 generic binding surface I; other site 685038000652 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 685038000653 lysine decarboxylase LdcC; Provisional; Region: PRK15399 685038000654 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 685038000655 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 685038000656 homodimer interface [polypeptide binding]; other site 685038000657 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685038000658 catalytic residue [active] 685038000659 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 685038000660 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 685038000661 putative metal binding site [ion binding]; other site 685038000662 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 685038000663 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 685038000664 Ligand Binding Site [chemical binding]; other site 685038000665 TilS substrate binding domain; Region: TilS; pfam09179 685038000666 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 685038000667 Rho-binding antiterminator; Provisional; Region: PRK11625 685038000668 hypothetical protein; Provisional; Region: PRK04964 685038000669 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 685038000670 hypothetical protein; Provisional; Region: PRK09256 685038000671 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 685038000672 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 685038000673 Uncharacterized lipoprotein NlpE involved in copper resistance [Cell envelope biogenesis, outer membrane / Inorganic ion transport and metabolism]; Region: CutF; COG3015 685038000674 hypothetical protein; Provisional; Region: PRK11479 685038000675 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 685038000676 prolyl-tRNA synthetase; Provisional; Region: PRK09194 685038000677 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 685038000678 dimer interface [polypeptide binding]; other site 685038000679 motif 1; other site 685038000680 active site 685038000681 motif 2; other site 685038000682 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 685038000683 putative deacylase active site [active] 685038000684 motif 3; other site 685038000685 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 685038000686 anticodon binding site; other site 685038000687 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 685038000688 homodimer interaction site [polypeptide binding]; other site 685038000689 cofactor binding site; other site 685038000690 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 685038000691 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 685038000692 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685038000693 dimer interface [polypeptide binding]; other site 685038000694 conserved gate region; other site 685038000695 putative PBP binding loops; other site 685038000696 ABC-ATPase subunit interface; other site 685038000697 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 685038000698 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 685038000699 Walker A/P-loop; other site 685038000700 ATP binding site [chemical binding]; other site 685038000701 Q-loop/lid; other site 685038000702 ABC transporter signature motif; other site 685038000703 Walker B; other site 685038000704 D-loop; other site 685038000705 H-loop/switch region; other site 685038000706 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 685038000707 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 685038000708 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 685038000709 active site 685038000710 motif I; other site 685038000711 motif II; other site 685038000712 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 685038000713 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 685038000714 active site 685038000715 catalytic tetrad [active] 685038000716 Transcriptional regulator [Transcription]; Region: LysR; COG0583 685038000717 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685038000718 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 685038000719 putative effector binding pocket; other site 685038000720 dimerization interface [polypeptide binding]; other site 685038000721 hypothetical protein; Provisional; Region: PRK05421 685038000722 putative catalytic site [active] 685038000723 putative metal binding site [ion binding]; other site 685038000724 putative phosphate binding site [ion binding]; other site 685038000725 putative catalytic site [active] 685038000726 putative phosphate binding site [ion binding]; other site 685038000727 putative metal binding site [ion binding]; other site 685038000728 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685038000729 S-adenosylmethionine binding site [chemical binding]; other site 685038000730 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 685038000731 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 685038000732 N-acetyl-D-glucosamine binding site [chemical binding]; other site 685038000733 catalytic residue [active] 685038000734 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 685038000735 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 685038000736 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 685038000737 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 685038000738 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 685038000739 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685038000740 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 685038000741 RNA/DNA hybrid binding site [nucleotide binding]; other site 685038000742 active site 685038000743 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 685038000744 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 685038000745 active site 685038000746 catalytic site [active] 685038000747 substrate binding site [chemical binding]; other site 685038000748 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 685038000749 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 685038000750 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 685038000751 ImpA domain protein; Region: DUF3702; pfam12486 685038000752 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 685038000753 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 685038000754 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 685038000755 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 685038000756 ImpA-related N-terminal; Region: ImpA-rel_N; cl19907 685038000757 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 685038000758 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 685038000759 type VI secretion-associated protein, VC_A0118 family; Region: VI_minor_1; TIGR03360 685038000760 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 685038000761 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685038000762 Walker A motif; other site 685038000763 ATP binding site [chemical binding]; other site 685038000764 Walker B motif; other site 685038000765 arginine finger; other site 685038000766 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685038000767 Walker A motif; other site 685038000768 ATP binding site [chemical binding]; other site 685038000769 Walker B motif; other site 685038000770 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 685038000771 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 685038000772 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 685038000773 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3521 685038000774 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 685038000775 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 685038000776 type VI secretion protein, VC_A0111 family; Region: VI_chp_1; TIGR03347 685038000777 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 685038000778 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 685038000779 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 685038000780 type VI secretion protein, VC_A0107 family; Region: VI_chp_5; TIGR03358 685038000781 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 685038000782 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 685038000783 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 685038000784 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 685038000785 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 685038000786 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 685038000787 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; cl02212 685038000788 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 685038000789 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259 685038000790 putative active site [active] 685038000791 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 685038000792 Transposase [DNA replication, recombination, and repair]; Region: COG5433 685038000793 Protein of unknown function (DUF2859); Region: DUF2859; pfam11072 685038000794 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 685038000795 putative active site [active] 685038000796 catalytic triad [active] 685038000797 dimer interface [polypeptide binding]; other site 685038000798 multimer interface [polypeptide binding]; other site 685038000799 C-lysozyme inhibitor; Provisional; Region: PRK09993 685038000800 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 685038000801 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 685038000802 active site 685038000803 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 685038000804 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 685038000805 dimer interface [polypeptide binding]; other site 685038000806 active site 685038000807 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 685038000808 putative active site [active] 685038000809 Glutamine amidotransferases class-II; Region: GATase_2; pfam00310 685038000810 putative dimer interface [polypeptide binding]; other site 685038000811 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 685038000812 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 685038000813 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 685038000814 NlpC/P60 family; Region: NLPC_P60; pfam00877 685038000815 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 685038000816 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298 685038000817 hypothetical protein; Validated; Region: PRK06778 685038000818 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 685038000819 ligand binding site [chemical binding]; other site 685038000820 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 685038000821 active site 685038000822 DNA polymerase IV; Validated; Region: PRK02406 685038000823 DNA binding site [nucleotide binding] 685038000824 putative antitoxin of the YafO-YafN toxin-antitoxin system; Provisional; Region: PRK09778 685038000825 putative toxin YafO; Provisional; Region: PRK09885 685038000826 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 685038000827 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 685038000828 Coenzyme A binding pocket [chemical binding]; other site 685038000829 hypothetical protein; Reviewed; Region: PRK09588 685038000830 tRNA-splicing ligase RtcB; Region: RtcB; pfam01139 685038000831 peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179 685038000832 putative peptide chain release factor H; Region: release_prfH; TIGR03072 685038000833 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 685038000834 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 685038000835 metal binding site [ion binding]; metal-binding site 685038000836 dimer interface [polypeptide binding]; other site 685038000837 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 685038000838 active site 685038000839 Putative lysophospholipase; Region: Hydrolase_4; cl19140 685038000840 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 685038000841 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 685038000842 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 685038000843 trimer interface [polypeptide binding]; other site 685038000844 eyelet of channel; other site 685038000845 gamma-glutamyl kinase; Provisional; Region: PRK05429 685038000846 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 685038000847 nucleotide binding site [chemical binding]; other site 685038000848 homotetrameric interface [polypeptide binding]; other site 685038000849 putative phosphate binding site [ion binding]; other site 685038000850 putative allosteric binding site; other site 685038000851 PUA domain; Region: PUA; pfam01472 685038000852 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 685038000853 putative catalytic cysteine [active] 685038000854 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 685038000855 MarR family; Region: MarR_2; cl17246 685038000856 Transcriptional regulators [Transcription]; Region: MarR; COG1846 685038000857 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 685038000858 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 685038000859 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 685038000860 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 685038000861 Autotransporter beta-domain; Region: Autotransporter; pfam03797 685038000862 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 685038000863 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 685038000864 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 685038000865 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 685038000866 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 685038000867 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 685038000868 fimbrial outer membrane usher protein TcfC; Provisional; Region: PRK15310 685038000869 Outer membrane usher protein; Region: Usher; pfam00577 685038000870 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 685038000871 putative fimbrial protein TcfA; Provisional; Region: PRK15308 685038000872 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 685038000873 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 685038000874 DNA binding residues [nucleotide binding] 685038000875 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 685038000876 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 685038000877 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 685038000878 putative active site [active] 685038000879 putative FMN binding site [chemical binding]; other site 685038000880 putative substrate binding site [chemical binding]; other site 685038000881 putative catalytic residue [active] 685038000882 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 685038000883 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 685038000884 Transcriptional regulator [Transcription]; Region: LysR; COG0583 685038000885 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685038000886 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 685038000887 putative effector binding pocket; other site 685038000888 putative dimerization interface [polypeptide binding]; other site 685038000889 Transcriptional regulator [Transcription]; Region: LysR; COG0583 685038000890 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685038000891 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 685038000892 putative effector binding pocket; other site 685038000893 putative dimerization interface [polypeptide binding]; other site 685038000894 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 685038000895 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 685038000896 active site 685038000897 catalytic tetrad [active] 685038000898 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 685038000899 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 685038000900 active site 685038000901 catalytic tetrad [active] 685038000902 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 685038000903 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 685038000904 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 685038000905 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 685038000906 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 685038000907 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 685038000908 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 685038000909 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 685038000910 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 685038000911 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 685038000912 active site 685038000913 catalytic tetrad [active] 685038000914 Predicted membrane protein [Function unknown]; Region: COG3059 685038000915 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 685038000916 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010 685038000917 Squalene epoxidase; Region: SE; cl17314 685038000918 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 685038000919 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 685038000920 Cupin; Region: Cupin_6; pfam12852 685038000921 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 685038000922 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 685038000923 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 685038000924 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 685038000925 Cysteine-rich domain; Region: CCG; pfam02754 685038000926 Cysteine-rich domain; Region: CCG; pfam02754 685038000927 iron-sulfur cluster-binding protein; Region: TIGR00273 685038000928 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 685038000929 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 685038000930 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 685038000931 Uncharacterized conserved protein [Function unknown]; Region: COG1556 685038000932 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 685038000933 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 685038000934 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 685038000935 Autotransporter beta-domain; Region: Autotransporter; pfam03797 685038000936 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 685038000937 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 685038000938 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 685038000939 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 685038000940 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 685038000941 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 685038000942 DNA binding residues [nucleotide binding] 685038000943 dimerization interface [polypeptide binding]; other site 685038000944 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 685038000945 active site 685038000946 DNA binding site [nucleotide binding] 685038000947 Int/Topo IB signature motif; other site 685038000948 choline dehydrogenase; Validated; Region: PRK02106 685038000949 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 685038000950 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 685038000951 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 685038000952 tetrameric interface [polypeptide binding]; other site 685038000953 NAD binding site [chemical binding]; other site 685038000954 catalytic residues [active] 685038000955 transcriptional regulator BetI; Validated; Region: PRK00767 685038000956 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685038000957 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 685038000958 choline transport protein BetT; Provisional; Region: PRK09928 685038000959 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 685038000960 DNA binding residues [nucleotide binding] 685038000961 dimerization interface [polypeptide binding]; other site 685038000962 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 685038000963 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 685038000964 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685038000965 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 685038000966 dimerization interface [polypeptide binding]; other site 685038000967 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 685038000968 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 685038000969 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 685038000970 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 685038000971 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 685038000972 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 685038000973 CoA binding domain; Region: CoA_binding; pfam02629 685038000974 CoA-ligase; Region: Ligase_CoA; pfam00549 685038000975 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 685038000976 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 685038000977 putative substrate binding site [chemical binding]; other site 685038000978 nucleotide binding site [chemical binding]; other site 685038000979 nucleotide binding site [chemical binding]; other site 685038000980 homodimer interface [polypeptide binding]; other site 685038000981 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 685038000982 cytosine deaminase; Provisional; Region: PRK05985 685038000983 active site 685038000984 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 685038000985 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 685038000986 putative NAD(P) binding site [chemical binding]; other site 685038000987 putative substrate binding site [chemical binding]; other site 685038000988 catalytic Zn binding site [ion binding]; other site 685038000989 structural Zn binding site [ion binding]; other site 685038000990 dimer interface [polypeptide binding]; other site 685038000991 potential protein location (hypothetical protein NRG857_01600 [Escherichia coli]) that overlaps RNA (tRNA-other) 685038000992 The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949 685038000993 hypothetical protein; Provisional; Region: PRK09929 685038000994 propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424 685038000995 Propionate catabolism activator; Region: PrpR_N; pfam06506 685038000996 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685038000997 Walker A motif; other site 685038000998 ATP binding site [chemical binding]; other site 685038000999 Walker B motif; other site 685038001000 arginine finger; other site 685038001001 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 685038001002 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 685038001003 tetramer interface [polypeptide binding]; other site 685038001004 active site 685038001005 Mg2+/Mn2+ binding site [ion binding]; other site 685038001006 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 685038001007 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 685038001008 dimer interface [polypeptide binding]; other site 685038001009 active site 685038001010 citrylCoA binding site [chemical binding]; other site 685038001011 oxalacetate/citrate binding site [chemical binding]; other site 685038001012 coenzyme A binding site [chemical binding]; other site 685038001013 catalytic triad [active] 685038001014 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 685038001015 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 685038001016 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 685038001017 acyl-activating enzyme (AAE) consensus motif; other site 685038001018 AMP binding site [chemical binding]; other site 685038001019 active site 685038001020 CoA binding site [chemical binding]; other site 685038001021 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 685038001022 Na binding site [ion binding]; other site 685038001023 putative substrate binding site [chemical binding]; other site 685038001024 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 685038001025 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 685038001026 active site 685038001027 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 685038001028 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 685038001029 active site 685038001030 substrate binding site [chemical binding]; other site 685038001031 trimer interface [polypeptide binding]; other site 685038001032 CoA binding site [chemical binding]; other site 685038001033 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 685038001034 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038001035 putative substrate translocation pore; other site 685038001036 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 685038001037 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 685038001038 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 685038001039 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 685038001040 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 685038001041 lac repressor; Reviewed; Region: lacI; PRK09526 685038001042 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 685038001043 DNA binding site [nucleotide binding] 685038001044 domain linker motif; other site 685038001045 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 685038001046 ligand binding site [chemical binding]; other site 685038001047 dimerization interface (open form) [polypeptide binding]; other site 685038001048 dimerization interface (closed form) [polypeptide binding]; other site 685038001049 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 685038001050 Predicted esterase [General function prediction only]; Region: COG0627 685038001051 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 685038001052 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 685038001053 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 685038001054 substrate binding site [chemical binding]; other site 685038001055 catalytic Zn binding site [ion binding]; other site 685038001056 NAD binding site [chemical binding]; other site 685038001057 structural Zn binding site [ion binding]; other site 685038001058 dimer interface [polypeptide binding]; other site 685038001059 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 685038001060 putative metal binding site [ion binding]; other site 685038001061 putative homodimer interface [polypeptide binding]; other site 685038001062 putative homotetramer interface [polypeptide binding]; other site 685038001063 putative homodimer-homodimer interface [polypeptide binding]; other site 685038001064 putative allosteric switch controlling residues; other site 685038001065 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 685038001066 putative trimer interface [polypeptide binding]; other site 685038001067 putative CoA binding site [chemical binding]; other site 685038001068 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 685038001069 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 685038001070 DXD motif; other site 685038001071 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 685038001072 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 685038001073 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 685038001074 substrate binding pocket [chemical binding]; other site 685038001075 membrane-bound complex binding site; other site 685038001076 hinge residues; other site 685038001077 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 685038001078 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 685038001079 Walker A/P-loop; other site 685038001080 ATP binding site [chemical binding]; other site 685038001081 Q-loop/lid; other site 685038001082 ABC transporter signature motif; other site 685038001083 Walker B; other site 685038001084 D-loop; other site 685038001085 H-loop/switch region; other site 685038001086 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 685038001087 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685038001088 dimer interface [polypeptide binding]; other site 685038001089 conserved gate region; other site 685038001090 putative PBP binding loops; other site 685038001091 ABC-ATPase subunit interface; other site 685038001092 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 685038001093 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 685038001094 active site 685038001095 iron coordination sites [ion binding]; other site 685038001096 substrate binding pocket [chemical binding]; other site 685038001097 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 685038001098 dimer interface [polypeptide binding]; other site 685038001099 active site 685038001100 Schiff base residues; other site 685038001101 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 685038001102 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 685038001103 Autotransporter beta-domain; Region: Autotransporter; pfam03797 685038001104 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 685038001105 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 685038001106 microcin B17 transporter; Reviewed; Region: PRK11098 685038001107 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 685038001108 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 685038001109 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 685038001110 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 685038001111 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 685038001112 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 685038001113 anti-RssB factor; Provisional; Region: PRK10244 685038001114 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 685038001115 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 685038001116 dimer interface [polypeptide binding]; other site 685038001117 active site 685038001118 hypothetical protein; Provisional; Region: PRK11505 685038001119 psiF repeat; Region: PsiF_repeat; pfam07769 685038001120 psiF repeat; Region: PsiF_repeat; pfam07769 685038001121 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 685038001122 MASE2 domain; Region: MASE2; pfam05230 685038001123 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 685038001124 metal binding site [ion binding]; metal-binding site 685038001125 active site 685038001126 I-site; other site 685038001127 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 685038001128 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 685038001129 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 685038001130 hypothetical protein; Validated; Region: PRK00124 685038001131 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 685038001132 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 685038001133 ADP binding site [chemical binding]; other site 685038001134 magnesium binding site [ion binding]; other site 685038001135 putative shikimate binding site; other site 685038001136 hypothetical protein; Provisional; Region: PRK10380 685038001137 hypothetical protein; Provisional; Region: PRK10481 685038001138 hypothetical protein; Provisional; Region: PRK10579 685038001139 Protein of unknown function (DUF2773); Region: DUF2773; pfam10971 685038001140 DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974 685038001141 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 685038001142 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 685038001143 nucleotide binding site [chemical binding]; other site 685038001144 MFS transport protein AraJ; Provisional; Region: PRK10091 685038001145 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038001146 putative substrate translocation pore; other site 685038001147 exonuclease subunit SbcC; Provisional; Region: PRK10246 685038001148 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685038001149 Walker A/P-loop; other site 685038001150 ATP binding site [chemical binding]; other site 685038001151 Q-loop/lid; other site 685038001152 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; cl19202 685038001153 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685038001154 ABC transporter signature motif; other site 685038001155 Walker B; other site 685038001156 D-loop; other site 685038001157 H-loop/switch region; other site 685038001158 exonuclease subunit SbcD; Provisional; Region: PRK10966 685038001159 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 685038001160 active site 685038001161 metal binding site [ion binding]; metal-binding site 685038001162 DNA binding site [nucleotide binding] 685038001163 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 685038001164 transcriptional regulator PhoB; Provisional; Region: PRK10161 685038001165 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685038001166 active site 685038001167 phosphorylation site [posttranslational modification] 685038001168 intermolecular recognition site; other site 685038001169 dimerization interface [polypeptide binding]; other site 685038001170 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 685038001171 DNA binding site [nucleotide binding] 685038001172 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 685038001173 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 685038001174 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 685038001175 putative active site [active] 685038001176 heme pocket [chemical binding]; other site 685038001177 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 685038001178 dimer interface [polypeptide binding]; other site 685038001179 phosphorylation site [posttranslational modification] 685038001180 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685038001181 ATP binding site [chemical binding]; other site 685038001182 Mg2+ binding site [ion binding]; other site 685038001183 G-X-G motif; other site 685038001184 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 685038001185 putative proline-specific permease; Provisional; Region: proY; PRK10580 685038001186 Spore germination protein; Region: Spore_permease; cl17796 685038001187 maltodextrin glucosidase; Provisional; Region: PRK10785 685038001188 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 685038001189 homodimer interface [polypeptide binding]; other site 685038001190 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 685038001191 active site 685038001192 homodimer interface [polypeptide binding]; other site 685038001193 catalytic site [active] 685038001194 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 685038001195 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 685038001196 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 685038001197 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 685038001198 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 685038001199 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 685038001200 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 685038001201 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 685038001202 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 685038001203 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 685038001204 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 685038001205 Protein export membrane protein; Region: SecD_SecF; pfam02355 685038001206 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 685038001207 active site 685038001208 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 685038001209 hypothetical protein; Provisional; Region: PRK11530 685038001210 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 685038001211 ATP cone domain; Region: ATP-cone; pfam03477 685038001212 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 685038001213 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 685038001214 catalytic motif [active] 685038001215 Zn binding site [ion binding]; other site 685038001216 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 685038001217 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 685038001218 homopentamer interface [polypeptide binding]; other site 685038001219 active site 685038001220 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 685038001221 thiamine monophosphate kinase; Provisional; Region: PRK05731 685038001222 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 685038001223 ATP binding site [chemical binding]; other site 685038001224 dimerization interface [polypeptide binding]; other site 685038001225 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 685038001226 tetramer interfaces [polypeptide binding]; other site 685038001227 binuclear metal-binding site [ion binding]; other site 685038001228 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 685038001229 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 685038001230 active site 685038001231 catalytic tetrad [active] 685038001232 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 685038001233 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 685038001234 TPP-binding site; other site 685038001235 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 685038001236 PYR/PP interface [polypeptide binding]; other site 685038001237 dimer interface [polypeptide binding]; other site 685038001238 TPP binding site [chemical binding]; other site 685038001239 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 685038001240 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 685038001241 substrate binding pocket [chemical binding]; other site 685038001242 chain length determination region; other site 685038001243 active site lid residues [active] 685038001244 substrate-Mg2+ binding site; other site 685038001245 catalytic residues [active] 685038001246 aspartate-rich region 1; other site 685038001247 aspartate-rich region 2; other site 685038001248 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 685038001249 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 685038001250 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 685038001251 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 685038001252 Ligand Binding Site [chemical binding]; other site 685038001253 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 685038001254 active site residue [active] 685038001255 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 685038001256 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 685038001257 conserved cys residue [active] 685038001258 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 685038001259 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 685038001260 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 685038001261 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 685038001262 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038001263 Major Facilitator Superfamily; Region: MFS_1; pfam07690 685038001264 putative substrate translocation pore; other site 685038001265 Protoheme IX farnesyltransferase; Region: PT_UbiA_Cox10; cd13957 685038001266 putative active site [active] 685038001267 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 685038001268 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 685038001269 Subunit I/III interface [polypeptide binding]; other site 685038001270 Subunit III/IV interface [polypeptide binding]; other site 685038001271 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 685038001272 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 685038001273 D-pathway; other site 685038001274 Putative ubiquinol binding site [chemical binding]; other site 685038001275 Low-spin heme (heme b) binding site [chemical binding]; other site 685038001276 Putative water exit pathway; other site 685038001277 Binuclear center (heme o3/CuB) [ion binding]; other site 685038001278 K-pathway; other site 685038001279 Putative proton exit pathway; other site 685038001280 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 685038001281 The cupredoxin domain of Ubiquinol oxidase subunit II; Region: CuRO_UO_II; cd04212 685038001282 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 685038001283 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038001284 Major Facilitator Superfamily; Region: MFS_1; pfam07690 685038001285 putative substrate translocation pore; other site 685038001286 hypothetical protein; Provisional; Region: PRK11627 685038001287 transcriptional regulator BolA; Provisional; Region: PRK11628 685038001288 trigger factor; Provisional; Region: tig; PRK01490 685038001289 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 685038001290 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 685038001291 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 685038001292 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 685038001293 oligomer interface [polypeptide binding]; other site 685038001294 active site residues [active] 685038001295 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 685038001296 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 685038001297 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685038001298 Walker A motif; other site 685038001299 ATP binding site [chemical binding]; other site 685038001300 Walker B motif; other site 685038001301 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 685038001302 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 685038001303 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 685038001304 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685038001305 Walker A motif; other site 685038001306 ATP binding site [chemical binding]; other site 685038001307 Walker B motif; other site 685038001308 arginine finger; other site 685038001309 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 685038001310 histone-like DNA-binding protein HU; Region: HU; cd13831 685038001311 dimer interface [polypeptide binding]; other site 685038001312 DNA binding site [nucleotide binding] 685038001313 periplasmic folding chaperone; Provisional; Region: PRK10788 685038001314 SurA N-terminal domain; Region: SurA_N_3; cl07813 685038001315 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 685038001316 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 685038001317 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 685038001318 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 685038001319 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 685038001320 active site 685038001321 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 685038001322 Ligand Binding Site [chemical binding]; other site 685038001323 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 685038001324 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 685038001325 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 685038001326 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 685038001327 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 685038001328 active site 685038001329 motif I; other site 685038001330 motif II; other site 685038001331 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 685038001332 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 685038001333 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 685038001334 putative DNA binding site [nucleotide binding]; other site 685038001335 putative Zn2+ binding site [ion binding]; other site 685038001336 AsnC family; Region: AsnC_trans_reg; pfam01037 685038001337 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 685038001338 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 685038001339 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685038001340 Walker A/P-loop; other site 685038001341 ATP binding site [chemical binding]; other site 685038001342 Q-loop/lid; other site 685038001343 ABC transporter signature motif; other site 685038001344 Walker B; other site 685038001345 D-loop; other site 685038001346 H-loop/switch region; other site 685038001347 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 685038001348 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 685038001349 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685038001350 Walker A/P-loop; other site 685038001351 ATP binding site [chemical binding]; other site 685038001352 Q-loop/lid; other site 685038001353 ABC transporter signature motif; other site 685038001354 Walker B; other site 685038001355 D-loop; other site 685038001356 H-loop/switch region; other site 685038001357 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 685038001358 ammonium transporter; Provisional; Region: PRK10666 685038001359 acyl-CoA thioesterase II; Provisional; Region: PRK10526 685038001360 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 685038001361 active site 685038001362 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 685038001363 catalytic triad [active] 685038001364 dimer interface [polypeptide binding]; other site 685038001365 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 685038001366 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 685038001367 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 685038001368 DNA binding site [nucleotide binding] 685038001369 active site 685038001370 Uncharacterized conserved protein [Function unknown]; Region: COG5507 685038001371 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 685038001372 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 685038001373 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 685038001374 Inner membrane protein YlaC; Region: YlaC; pfam10777 685038001375 maltose O-acetyltransferase; Provisional; Region: PRK10092 685038001376 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 685038001377 active site 685038001378 substrate binding site [chemical binding]; other site 685038001379 trimer interface [polypeptide binding]; other site 685038001380 CoA binding site [chemical binding]; other site 685038001381 gene expression modulator; Provisional; Region: PRK10945 685038001382 Biofilm formation regulator YbaJ; Region: YbaJ; pfam10757 685038001383 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 685038001384 MMPL family; Region: MMPL; cl14618 685038001385 MMPL family; Region: MMPL; cl14618 685038001386 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 685038001387 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 685038001388 HlyD family secretion protein; Region: HlyD_3; pfam13437 685038001389 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 685038001390 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685038001391 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 685038001392 hypothetical protein; Provisional; Region: PRK11281 685038001393 FSIP1 family; Region: FSIP1; pfam15554 685038001394 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 685038001395 Mechanosensitive ion channel; Region: MS_channel; pfam00924 685038001396 hypothetical protein; Provisional; Region: PRK11038 685038001397 primosomal replication protein N''; Provisional; Region: PRK10093 685038001398 hypothetical protein; Provisional; Region: PRK10527 685038001399 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 685038001400 active site 685038001401 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 685038001402 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685038001403 Walker A motif; other site 685038001404 ATP binding site [chemical binding]; other site 685038001405 Walker B motif; other site 685038001406 DNA polymerase III subunit delta'; Validated; Region: PRK08485 685038001407 arginine finger; other site 685038001408 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 685038001409 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 685038001410 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 685038001411 hypothetical protein; Validated; Region: PRK00153 685038001412 recombination protein RecR; Reviewed; Region: recR; PRK00076 685038001413 RecR protein; Region: RecR; pfam02132 685038001414 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 685038001415 putative active site [active] 685038001416 putative metal-binding site [ion binding]; other site 685038001417 tetramer interface [polypeptide binding]; other site 685038001418 heat shock protein 90; Provisional; Region: PRK05218 685038001419 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685038001420 ATP binding site [chemical binding]; other site 685038001421 Mg2+ binding site [ion binding]; other site 685038001422 G-X-G motif; other site 685038001423 Hsp90 protein; Region: HSP90; pfam00183 685038001424 adenylate kinase; Reviewed; Region: adk; PRK00279 685038001425 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 685038001426 AMP-binding site [chemical binding]; other site 685038001427 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 685038001428 ferrochelatase; Region: hemH; TIGR00109 685038001429 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 685038001430 C-terminal domain interface [polypeptide binding]; other site 685038001431 active site 685038001432 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 685038001433 active site 685038001434 N-terminal domain interface [polypeptide binding]; other site 685038001435 acetyl esterase; Provisional; Region: PRK10162 685038001436 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 685038001437 inosine/guanosine kinase; Provisional; Region: PRK15074 685038001438 adenosine kinase; Provisional; Region: PTZ00247 685038001439 substrate binding site [chemical binding]; other site 685038001440 ATP binding site [chemical binding]; other site 685038001441 putative cation:proton antiport protein; Provisional; Region: PRK10669 685038001442 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 685038001443 TrkA-N domain; Region: TrkA_N; pfam02254 685038001444 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038001445 Major Facilitator Superfamily; Region: MFS_1; pfam07690 685038001446 putative substrate translocation pore; other site 685038001447 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 685038001448 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 685038001449 active site 685038001450 metal binding site [ion binding]; metal-binding site 685038001451 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 685038001452 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 685038001453 putative deacylase active site [active] 685038001454 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 685038001455 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 685038001456 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 685038001457 non-specific DNA binding site [nucleotide binding]; other site 685038001458 salt bridge; other site 685038001459 sequence-specific DNA binding site [nucleotide binding]; other site 685038001460 copper exporting ATPase; Provisional; Region: copA; PRK10671 685038001461 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 685038001462 metal-binding site [ion binding] 685038001463 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 685038001464 metal-binding site [ion binding] 685038001465 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 685038001466 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 685038001467 motif II; other site 685038001468 glutaminase; Reviewed; Region: PRK12356 685038001469 amino acid transporter; Region: 2A0306; TIGR00909 685038001470 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 685038001471 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 685038001472 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 685038001473 DNA binding residues [nucleotide binding] 685038001474 dimer interface [polypeptide binding]; other site 685038001475 copper binding site [ion binding]; other site 685038001476 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 685038001477 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 685038001478 Paraslipin or slipin-2 (SLP-2, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_paraslipin; cd08829 685038001479 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 685038001480 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685038001481 Walker A/P-loop; other site 685038001482 ATP binding site [chemical binding]; other site 685038001483 Q-loop/lid; other site 685038001484 ABC transporter signature motif; other site 685038001485 Walker B; other site 685038001486 D-loop; other site 685038001487 H-loop/switch region; other site 685038001488 TIGR00245 family protein; Region: TIGR00245 685038001489 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 685038001490 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 685038001491 Tetratricopeptide repeat; Region: TPR_20; pfam14561 685038001492 short chain dehydrogenase; Validated; Region: PRK06182 685038001493 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 685038001494 NADP binding site [chemical binding]; other site 685038001495 active site 685038001496 steroid binding site; other site 685038001497 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 685038001498 active site 685038001499 catalytic triad [active] 685038001500 oxyanion hole [active] 685038001501 switch loop; other site 685038001502 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 685038001503 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 685038001504 Walker A/P-loop; other site 685038001505 ATP binding site [chemical binding]; other site 685038001506 Q-loop/lid; other site 685038001507 ABC transporter signature motif; other site 685038001508 Walker B; other site 685038001509 D-loop; other site 685038001510 H-loop/switch region; other site 685038001511 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 685038001512 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 685038001513 FtsX-like permease family; Region: FtsX; pfam02687 685038001514 FtsX-like permease family; Region: FtsX; pfam02687 685038001515 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 685038001516 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 685038001517 active site residue [active] 685038001518 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 685038001519 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685038001520 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 685038001521 dimerization interface [polypeptide binding]; other site 685038001522 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 685038001523 DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163 685038001524 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 685038001525 Bacterial transcriptional regulator; Region: IclR; pfam01614 685038001526 glyoxylate carboligase; Provisional; Region: PRK11269 685038001527 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 685038001528 PYR/PP interface [polypeptide binding]; other site 685038001529 dimer interface [polypeptide binding]; other site 685038001530 TPP binding site [chemical binding]; other site 685038001531 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 685038001532 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 685038001533 TPP-binding site [chemical binding]; other site 685038001534 hydroxypyruvate isomerase; Provisional; Region: PRK09997 685038001535 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 685038001536 tartronate semialdehyde reductase; Provisional; Region: PRK15059 685038001537 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 685038001538 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 685038001539 nucleobase-cation-symport-1 (NCS1) transporters; solute-binding domain; Region: SLC-NCS1sbd; cd10323 685038001540 Na binding site [ion binding]; other site 685038001541 substrate binding site [chemical binding]; other site 685038001542 allantoinase; Provisional; Region: PRK08044 685038001543 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 685038001544 active site 685038001545 putative uracil/xanthine transporter; Provisional; Region: PRK11412 685038001546 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 685038001547 glycerate kinase II; Provisional; Region: PRK09932 685038001548 Uncharacterized protein, possibly involved in glyoxylate utilization [General function prediction only]; Region: GlxB; COG3257 685038001549 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 685038001550 Cupin domain; Region: Cupin_2; cl17218 685038001551 allantoate amidohydrolase; Region: AllC; TIGR03176 685038001552 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 685038001553 active site 685038001554 metal binding site [ion binding]; metal-binding site 685038001555 dimer interface [polypeptide binding]; other site 685038001556 ureidoglycolate dehydrogenase; Provisional; Region: PRK15025 685038001557 membrane protein FdrA; Validated; Region: PRK06091 685038001558 CoA binding domain; Region: CoA_binding; pfam02629 685038001559 CoA-ligase; Region: Ligase_CoA; pfam00549 685038001560 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 685038001561 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 685038001562 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 685038001563 putative substrate binding site [chemical binding]; other site 685038001564 nucleotide binding site [chemical binding]; other site 685038001565 nucleotide binding site [chemical binding]; other site 685038001566 homodimer interface [polypeptide binding]; other site 685038001567 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 685038001568 ATP-grasp domain; Region: ATP-grasp; pfam02222 685038001569 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 685038001570 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 685038001571 putative active site [active] 685038001572 putative metal binding site [ion binding]; other site 685038001573 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 685038001574 substrate binding site [chemical binding]; other site 685038001575 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 685038001576 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 685038001577 active site 685038001578 HIGH motif; other site 685038001579 KMSKS motif; other site 685038001580 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 685038001581 tRNA binding surface [nucleotide binding]; other site 685038001582 anticodon binding site; other site 685038001583 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 685038001584 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 685038001585 RNA binding surface [nucleotide binding]; other site 685038001586 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 685038001587 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 685038001588 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 685038001589 homodimer interface [polypeptide binding]; other site 685038001590 NADP binding site [chemical binding]; other site 685038001591 substrate binding site [chemical binding]; other site 685038001592 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 685038001593 DNA binding site [nucleotide binding] 685038001594 active site 685038001595 Int/Topo IB signature motif; other site 685038001596 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 685038001597 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 685038001598 Methyltransferase domain; Region: Methyltransf_31; pfam13847 685038001599 Methyltransferase domain; Region: Methyltransf_12; pfam08242 685038001600 outer membrane protease; Reviewed; Region: PRK10993 685038001601 hypothetical protein; Provisional; Region: PRK09936 685038001602 bacteriophage N4 receptor, outer membrane subunit; Provisional; Region: PRK09782 685038001603 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 685038001604 TPR motif; other site 685038001605 binding surface 685038001606 Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283 685038001607 bacteriophage N4 adsorption protein B; Provisional; Region: PRK14716 685038001608 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 685038001609 active site 685038001610 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 685038001611 sensor kinase CusS; Provisional; Region: PRK09835 685038001612 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 685038001613 dimerization interface [polypeptide binding]; other site 685038001614 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 685038001615 dimer interface [polypeptide binding]; other site 685038001616 phosphorylation site [posttranslational modification] 685038001617 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685038001618 ATP binding site [chemical binding]; other site 685038001619 Mg2+ binding site [ion binding]; other site 685038001620 G-X-G motif; other site 685038001621 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 685038001622 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685038001623 active site 685038001624 phosphorylation site [posttranslational modification] 685038001625 intermolecular recognition site; other site 685038001626 dimerization interface [polypeptide binding]; other site 685038001627 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 685038001628 DNA binding site [nucleotide binding] 685038001629 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 685038001630 Outer membrane efflux protein; Region: OEP; pfam02321 685038001631 Outer membrane efflux protein; Region: OEP; pfam02321 685038001632 periplasmic copper-binding protein; Provisional; Region: PRK09838 685038001633 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 685038001634 HlyD family secretion protein; Region: HlyD_3; pfam13437 685038001635 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 685038001636 phenylalanine transporter; Provisional; Region: PRK10249 685038001637 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 685038001638 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 685038001639 Mechanosensitive ion channel; Region: MS_channel; pfam00924 685038001640 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 685038001641 dimer interface [polypeptide binding]; other site 685038001642 FMN binding site [chemical binding]; other site 685038001643 hypothetical protein; Provisional; Region: PRK10250 685038001644 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 685038001645 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 685038001646 Hok/gef family; Region: HOK_GEF; pfam01848 685038001647 Hok/gef family; Region: HOK_GEF; pfam01848 685038001648 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 685038001649 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 685038001650 outer membrane receptor FepA; Provisional; Region: PRK13524 685038001651 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 685038001652 N-terminal plug; other site 685038001653 ligand-binding site [chemical binding]; other site 685038001654 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 685038001655 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 685038001656 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 685038001657 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 685038001658 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 685038001659 Condensation domain; Region: Condensation; pfam00668 685038001660 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 685038001661 acyl-activating enzyme (AAE) consensus motif; other site 685038001662 AMP binding site [chemical binding]; other site 685038001663 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 685038001664 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 685038001665 LPS O-antigen length regulator; Provisional; Region: PRK10381 685038001666 Chain length determinant protein; Region: Wzz; pfam02706 685038001667 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 685038001668 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 685038001669 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 685038001670 Walker A/P-loop; other site 685038001671 ATP binding site [chemical binding]; other site 685038001672 Q-loop/lid; other site 685038001673 ABC transporter signature motif; other site 685038001674 Walker B; other site 685038001675 D-loop; other site 685038001676 H-loop/switch region; other site 685038001677 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 685038001678 ABC-ATPase subunit interface; other site 685038001679 dimer interface [polypeptide binding]; other site 685038001680 putative PBP binding regions; other site 685038001681 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 685038001682 ABC-ATPase subunit interface; other site 685038001683 dimer interface [polypeptide binding]; other site 685038001684 putative PBP binding regions; other site 685038001685 enterobactin exporter EntS; Provisional; Region: PRK10489 685038001686 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038001687 putative substrate translocation pore; other site 685038001688 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 685038001689 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 685038001690 siderophore binding site; other site 685038001691 isochorismate synthase EntC; Provisional; Region: PRK15016 685038001692 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 685038001693 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 685038001694 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 685038001695 acyl-activating enzyme (AAE) consensus motif; other site 685038001696 active site 685038001697 AMP binding site [chemical binding]; other site 685038001698 substrate binding site [chemical binding]; other site 685038001699 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 685038001700 hydrophobic substrate binding pocket; other site 685038001701 active site 685038001702 conserved cis-peptide bond; other site 685038001703 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 685038001704 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 685038001705 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 685038001706 putative NAD(P) binding site [chemical binding]; other site 685038001707 active site 685038001708 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 685038001709 CoenzymeA binding site [chemical binding]; other site 685038001710 subunit interaction site [polypeptide binding]; other site 685038001711 PHB binding site; other site 685038001712 carbon starvation protein A; Provisional; Region: PRK15015 685038001713 Carbon starvation protein CstA; Region: CstA; pfam02554 685038001714 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 685038001715 Uncharacterized small protein [Function unknown]; Region: COG2879 685038001716 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 685038001717 putative active site [active] 685038001718 metal binding site [ion binding]; metal-binding site 685038001719 methionine aminotransferase; Validated; Region: PRK09082 685038001720 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 685038001721 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685038001722 homodimer interface [polypeptide binding]; other site 685038001723 catalytic residue [active] 685038001724 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 685038001725 ParB-like nuclease domain; Region: ParBc; pfam02195 685038001726 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 685038001727 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 685038001728 Active Sites [active] 685038001729 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 685038001730 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 685038001731 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685038001732 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 685038001733 dimerization interface [polypeptide binding]; other site 685038001734 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 685038001735 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 685038001736 dimerization domain [polypeptide binding]; other site 685038001737 dimer interface [polypeptide binding]; other site 685038001738 catalytic residues [active] 685038001739 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 685038001740 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 685038001741 dimer interface [polypeptide binding]; other site 685038001742 decamer (pentamer of dimers) interface [polypeptide binding]; other site 685038001743 catalytic triad [active] 685038001744 peroxidatic and resolving cysteines [active] 685038001745 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 685038001746 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 685038001747 catalytic residue [active] 685038001748 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 685038001749 catalytic residues [active] 685038001750 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 685038001751 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 685038001752 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 685038001753 Ligand Binding Site [chemical binding]; other site 685038001754 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 685038001755 Rnk N-terminus; Region: Rnk_N; pfam14760 685038001756 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 685038001757 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 685038001758 B1 nucleotide binding pocket [chemical binding]; other site 685038001759 B2 nucleotide binding pocket [chemical binding]; other site 685038001760 CAS motifs; other site 685038001761 active site 685038001762 anion transporter; Region: dass; TIGR00785 685038001763 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 685038001764 transmembrane helices; other site 685038001765 triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096 685038001766 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 685038001767 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 685038001768 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 685038001769 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 685038001770 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 685038001771 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 685038001772 putative active site [active] 685038001773 (T/H)XGH motif; other site 685038001774 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 685038001775 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 685038001776 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 685038001777 putative active site [active] 685038001778 heme pocket [chemical binding]; other site 685038001779 Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689 685038001780 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685038001781 ATP binding site [chemical binding]; other site 685038001782 Mg2+ binding site [ion binding]; other site 685038001783 G-X-G motif; other site 685038001784 two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046 685038001785 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685038001786 active site 685038001787 phosphorylation site [posttranslational modification] 685038001788 intermolecular recognition site; other site 685038001789 dimerization interface [polypeptide binding]; other site 685038001790 Transcriptional regulator; Region: CitT; pfam12431 685038001791 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 685038001792 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; COG3069 685038001793 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 685038001794 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 685038001795 DNA-binding site [nucleotide binding]; DNA binding site 685038001796 RNA-binding motif; other site 685038001797 chromosome condensation membrane protein; Provisional; Region: PRK14196 685038001798 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 685038001799 putative active site [active] 685038001800 catalytic triad [active] 685038001801 putative dimer interface [polypeptide binding]; other site 685038001802 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 685038001803 lipoyl synthase; Provisional; Region: PRK05481 685038001804 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 685038001805 FeS/SAM binding site; other site 685038001806 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 685038001807 lipoate-protein ligase B; Provisional; Region: PRK14342 685038001808 hypothetical protein; Provisional; Region: PRK04998 685038001809 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 685038001810 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 685038001811 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 685038001812 rare lipoprotein A; Provisional; Region: PRK10672 685038001813 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 685038001814 Sporulation related domain; Region: SPOR; pfam05036 685038001815 cell wall shape-determining protein; Provisional; Region: PRK10794 685038001816 penicillin-binding protein 2; Provisional; Region: PRK10795 685038001817 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 685038001818 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 685038001819 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 685038001820 ribosome-associated protein; Provisional; Region: PRK11538 685038001821 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 685038001822 catalytic core [active] 685038001823 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 685038001824 active site 685038001825 (T/H)XGH motif; other site 685038001826 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 685038001827 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 685038001828 Processivity clamp loader gamma complex DNA pol III C-term; Region: DNA_pol3_delt_C; pfam14840 685038001829 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 685038001830 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 685038001831 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 685038001832 active site 685038001833 HIGH motif; other site 685038001834 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 685038001835 KMSKS motif; other site 685038001836 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 685038001837 tRNA binding surface [nucleotide binding]; other site 685038001838 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 685038001839 hypothetical protein; Provisional; Region: PRK11032 685038001840 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 685038001841 active site 685038001842 tetramer interface [polypeptide binding]; other site 685038001843 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 685038001844 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 685038001845 Walker A/P-loop; other site 685038001846 ATP binding site [chemical binding]; other site 685038001847 Q-loop/lid; other site 685038001848 ABC transporter signature motif; other site 685038001849 Walker B; other site 685038001850 D-loop; other site 685038001851 H-loop/switch region; other site 685038001852 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 685038001853 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685038001854 dimer interface [polypeptide binding]; other site 685038001855 conserved gate region; other site 685038001856 putative PBP binding loops; other site 685038001857 ABC-ATPase subunit interface; other site 685038001858 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 685038001859 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685038001860 dimer interface [polypeptide binding]; other site 685038001861 conserved gate region; other site 685038001862 putative PBP binding loops; other site 685038001863 ABC-ATPase subunit interface; other site 685038001864 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 685038001865 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 685038001866 substrate binding pocket [chemical binding]; other site 685038001867 membrane-bound complex binding site; other site 685038001868 hinge residues; other site 685038001869 Rhomboid family; Region: Rhomboid; pfam01694 685038001870 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 685038001871 Uncharacterized conserved protein [Function unknown]; Region: COG3391 685038001872 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 685038001873 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 685038001874 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 685038001875 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 685038001876 putative active site [active] 685038001877 catalytic triad [active] 685038001878 putative dimer interface [polypeptide binding]; other site 685038001879 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 685038001880 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 685038001881 Transporter associated domain; Region: CorC_HlyC; smart01091 685038001882 metal-binding heat shock protein; Provisional; Region: PRK00016 685038001883 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 685038001884 PhoH-like protein; Region: PhoH; pfam02562 685038001885 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 685038001886 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 685038001887 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 685038001888 FeS/SAM binding site; other site 685038001889 TRAM domain; Region: TRAM; pfam01938 685038001890 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 685038001891 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 685038001892 asparagine synthetase B; Provisional; Region: asnB; PRK09431 685038001893 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 685038001894 active site 685038001895 dimer interface [polypeptide binding]; other site 685038001896 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 685038001897 Ligand Binding Site [chemical binding]; other site 685038001898 Molecular Tunnel; other site 685038001899 UMP phosphatase; Provisional; Region: PRK10444 685038001900 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 685038001901 active site 685038001902 motif I; other site 685038001903 motif II; other site 685038001904 MarR family; Region: MarR_2; cl17246 685038001905 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 685038001906 ROK family; Region: ROK; pfam00480 685038001907 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 685038001908 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 685038001909 active site 685038001910 dimer interface [polypeptide binding]; other site 685038001911 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 685038001912 active site 685038001913 trimer interface [polypeptide binding]; other site 685038001914 allosteric site; other site 685038001915 active site lid [active] 685038001916 hexamer (dimer of trimers) interface [polypeptide binding]; other site 685038001917 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 685038001918 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 685038001919 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 685038001920 active site turn [active] 685038001921 phosphorylation site [posttranslational modification] 685038001922 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 685038001923 HPr interaction site; other site 685038001924 glycerol kinase (GK) interaction site [polypeptide binding]; other site 685038001925 active site 685038001926 phosphorylation site [posttranslational modification] 685038001927 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 685038001928 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 685038001929 transmembrane helices; other site 685038001930 Domain of unknown function (DUF386); Region: DUF386; cl01047 685038001931 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 685038001932 BNR repeat-like domain; Region: BNR_2; pfam13088 685038001933 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 685038001934 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 685038001935 inhibitor site; inhibition site 685038001936 active site 685038001937 dimer interface [polypeptide binding]; other site 685038001938 catalytic residue [active] 685038001939 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 685038001940 active site 685038001941 NAD binding site [chemical binding]; other site 685038001942 metal binding site [ion binding]; metal-binding site 685038001943 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 685038001944 4-hydroxythreonine-4-phosphate dehydrogenase 2; Provisional; Region: pdxA; PRK03371 685038001945 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 685038001946 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 685038001947 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 685038001948 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 685038001949 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 685038001950 active site 685038001951 HIGH motif; other site 685038001952 KMSKS motif; other site 685038001953 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 685038001954 outer membrane porin, OprD family; Region: OprD; pfam03573 685038001955 YbfN-like lipoprotein; Region: YbfN; pfam13982 685038001956 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 685038001957 metal binding site 2 [ion binding]; metal-binding site 685038001958 putative DNA binding helix; other site 685038001959 metal binding site 1 [ion binding]; metal-binding site 685038001960 dimer interface [polypeptide binding]; other site 685038001961 structural Zn2+ binding site [ion binding]; other site 685038001962 flavodoxin FldA; Validated; Region: PRK09267 685038001963 LexA regulated protein; Provisional; Region: PRK11675 685038001964 acyl-CoA esterase; Provisional; Region: PRK10673 685038001965 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 685038001966 replication initiation regulator SeqA; Provisional; Region: PRK11187 685038001967 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 685038001968 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 685038001969 active site 685038001970 substrate binding site [chemical binding]; other site 685038001971 metal binding site [ion binding]; metal-binding site 685038001972 putrescine transporter; Provisional; Region: potE; PRK10655 685038001973 ornithine decarboxylase; Provisional; Region: PRK13578 685038001974 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 685038001975 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 685038001976 homodimer interface [polypeptide binding]; other site 685038001977 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685038001978 catalytic residue [active] 685038001979 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 685038001980 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 685038001981 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685038001982 active site 685038001983 phosphorylation site [posttranslational modification] 685038001984 intermolecular recognition site; other site 685038001985 dimerization interface [polypeptide binding]; other site 685038001986 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 685038001987 DNA binding site [nucleotide binding] 685038001988 sensor protein KdpD; Provisional; Region: PRK10490 685038001989 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 685038001990 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 685038001991 Ligand Binding Site [chemical binding]; other site 685038001992 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 685038001993 GAF domain; Region: GAF_3; pfam13492 685038001994 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 685038001995 dimer interface [polypeptide binding]; other site 685038001996 phosphorylation site [posttranslational modification] 685038001997 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685038001998 ATP binding site [chemical binding]; other site 685038001999 Mg2+ binding site [ion binding]; other site 685038002000 G-X-G motif; other site 685038002001 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 685038002002 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 685038002003 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 685038002004 Soluble P-type ATPase [General function prediction only]; Region: COG4087 685038002005 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 685038002006 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 685038002007 hypothetical protein; Provisional; Region: PRK10167 685038002008 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 685038002009 DNA photolyase; Region: DNA_photolyase; pfam00875 685038002010 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 685038002011 dipeptide/tripeptide permease D; Provisional; Region: PRK15462 685038002012 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 685038002013 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038002014 putative substrate translocation pore; other site 685038002015 metal-binding protein; Provisional; Region: PRK10799 685038002016 Allophanate hydrolase subunit 1; Region: AHS1; cl19310 685038002017 biotin-dependent carboxylase uncharacterized domain; Region: urea_amlyse_rel; TIGR00724 685038002018 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 685038002019 putative active site [active] 685038002020 endonuclease VIII; Provisional; Region: PRK10445 685038002021 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 685038002022 DNA binding site [nucleotide binding] 685038002023 catalytic residue [active] 685038002024 putative catalytic residues [active] 685038002025 H2TH interface [polypeptide binding]; other site 685038002026 intercalation triad [nucleotide binding]; other site 685038002027 substrate specificity determining residue; other site 685038002028 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 685038002029 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 685038002030 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 685038002031 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 685038002032 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 685038002033 Fimbrial protein; Region: Fimbrial; cl01416 685038002034 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 685038002035 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 685038002036 dimer interface [polypeptide binding]; other site 685038002037 active site 685038002038 citrylCoA binding site [chemical binding]; other site 685038002039 NADH binding [chemical binding]; other site 685038002040 cationic pore residues; other site 685038002041 oxalacetate/citrate binding site [chemical binding]; other site 685038002042 coenzyme A binding site [chemical binding]; other site 685038002043 catalytic triad [active] 685038002044 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 685038002045 Iron-sulfur protein interface; other site 685038002046 proximal quinone binding site [chemical binding]; other site 685038002047 SdhD (CybS) interface [polypeptide binding]; other site 685038002048 proximal heme binding site [chemical binding]; other site 685038002049 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 685038002050 SdhC subunit interface [polypeptide binding]; other site 685038002051 proximal heme binding site [chemical binding]; other site 685038002052 cardiolipin binding site; other site 685038002053 Iron-sulfur protein interface; other site 685038002054 proximal quinone binding site [chemical binding]; other site 685038002055 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 685038002056 L-aspartate oxidase; Provisional; Region: PRK06175 685038002057 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 685038002058 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 685038002059 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 685038002060 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 685038002061 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 685038002062 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 685038002063 TPP-binding site [chemical binding]; other site 685038002064 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 685038002065 dimer interface [polypeptide binding]; other site 685038002066 PYR/PP interface [polypeptide binding]; other site 685038002067 TPP binding site [chemical binding]; other site 685038002068 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 685038002069 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 685038002070 E3 interaction surface; other site 685038002071 lipoyl attachment site [posttranslational modification]; other site 685038002072 e3 binding domain; Region: E3_binding; pfam02817 685038002073 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 685038002074 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 685038002075 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 685038002076 CoA-ligase; Region: Ligase_CoA; pfam00549 685038002077 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 685038002078 CoA binding domain; Region: CoA_binding; pfam02629 685038002079 CoA-ligase; Region: Ligase_CoA; pfam00549 685038002080 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; cl19870 685038002081 TPR repeat; Region: TPR_11; pfam13414 685038002082 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 685038002083 binding surface 685038002084 TPR motif; other site 685038002085 Tetratricopeptide repeat; Region: TPR_12; pfam13424 685038002086 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 685038002087 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 685038002088 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 685038002089 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 685038002090 hypothetical protein; Provisional; Region: PRK10588 685038002091 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 685038002092 active site 685038002093 colicin uptake protein TolQ; Provisional; Region: PRK10801 685038002094 colicin uptake protein TolR; Provisional; Region: PRK11024 685038002095 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 685038002096 Double-stranded DNA-binding domain; Region: dsDNA_bind; cl00928 685038002097 TolA C-terminal; Region: TolA; pfam06519 685038002098 translocation protein TolB; Provisional; Region: tolB; PRK03629 685038002099 TolB amino-terminal domain; Region: TolB_N; pfam04052 685038002100 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 685038002101 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 685038002102 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 685038002103 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 685038002104 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 685038002105 ligand binding site [chemical binding]; other site 685038002106 tol-pal system protein YbgF; Provisional; Region: PRK10803 685038002107 Tetratricopeptide repeat; Region: TPR_6; pfam13174 685038002108 Tetratricopeptide repeat; Region: TPR_6; pfam13174 685038002109 quinolinate synthetase; Provisional; Region: PRK09375 685038002110 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 685038002111 zinc transporter ZitB; Provisional; Region: PRK03557 685038002112 YbgS-like protein; Region: YbgS; pfam13985 685038002113 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 685038002114 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 685038002115 catalytic core [active] 685038002116 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 685038002117 active site 685038002118 catalytic residues [active] 685038002119 galactokinase; Provisional; Region: PRK05101 685038002120 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 685038002121 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 685038002122 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 685038002123 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 685038002124 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 685038002125 dimer interface [polypeptide binding]; other site 685038002126 active site 685038002127 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 685038002128 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 685038002129 NAD binding site [chemical binding]; other site 685038002130 homodimer interface [polypeptide binding]; other site 685038002131 active site 685038002132 substrate binding site [chemical binding]; other site 685038002133 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 685038002134 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 685038002135 Walker A/P-loop; other site 685038002136 ATP binding site [chemical binding]; other site 685038002137 Q-loop/lid; other site 685038002138 ABC transporter signature motif; other site 685038002139 Walker B; other site 685038002140 D-loop; other site 685038002141 H-loop/switch region; other site 685038002142 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685038002143 Walker A/P-loop; other site 685038002144 ATP binding site [chemical binding]; other site 685038002145 Q-loop/lid; other site 685038002146 ABC transporter signature motif; other site 685038002147 Walker B; other site 685038002148 D-loop; other site 685038002149 H-loop/switch region; other site 685038002150 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 685038002151 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 685038002152 molybdenum-pterin binding domain; Region: Mop; TIGR00638 685038002153 TOBE domain; Region: TOBE; pfam03459 685038002154 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 685038002155 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 685038002156 substrate binding pocket [chemical binding]; other site 685038002157 membrane-bound complex binding site; other site 685038002158 hinge residues; other site 685038002159 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 685038002160 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685038002161 dimer interface [polypeptide binding]; other site 685038002162 conserved gate region; other site 685038002163 putative PBP binding loops; other site 685038002164 ABC-ATPase subunit interface; other site 685038002165 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 685038002166 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685038002167 Walker A/P-loop; other site 685038002168 ATP binding site [chemical binding]; other site 685038002169 Q-loop/lid; other site 685038002170 ABC transporter signature motif; other site 685038002171 Walker B; other site 685038002172 D-loop; other site 685038002173 H-loop/switch region; other site 685038002174 molybdenum-pterin binding domain; Region: Mop; TIGR00638 685038002175 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 685038002176 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 685038002177 active site 685038002178 motif I; other site 685038002179 motif II; other site 685038002180 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 685038002181 6-phosphogluconolactonase; Provisional; Region: PRK11028 685038002182 Transcriptional regulator [Transcription]; Region: LysR; COG0583 685038002183 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685038002184 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 685038002185 putative dimerization interface [polypeptide binding]; other site 685038002186 PrpF protein; Region: PrpF; pfam04303 685038002187 Sodium:sulfate symporter transmembrane region; Region: Na_sulph_symp; pfam00939 685038002188 anion transporter; Region: dass; TIGR00785 685038002189 transmembrane helices; other site 685038002190 putative hydratase; Provisional; Region: PRK11413 685038002191 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 685038002192 substrate binding site [chemical binding]; other site 685038002193 ligand binding site [chemical binding]; other site 685038002194 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 685038002195 substrate binding site [chemical binding]; other site 685038002196 acyl-CoA thioesterase; Provisional; Region: PRK10531 685038002197 Pectinesterase; Region: Pectinesterase; cl01911 685038002198 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 685038002199 substrate binding site [chemical binding]; other site 685038002200 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 685038002201 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 685038002202 Probable transposase; Region: OrfB_IS605; pfam01385 685038002203 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 685038002204 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 685038002205 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 685038002206 inhibitor-cofactor binding pocket; inhibition site 685038002207 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685038002208 catalytic residue [active] 685038002209 biotin synthase; Provisional; Region: PRK15108 685038002210 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 685038002211 FeS/SAM binding site; other site 685038002212 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 685038002213 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 685038002214 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 685038002215 substrate-cofactor binding pocket; other site 685038002216 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685038002217 catalytic residue [active] 685038002218 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 685038002219 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685038002220 S-adenosylmethionine binding site [chemical binding]; other site 685038002221 AAA domain; Region: AAA_26; pfam13500 685038002222 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 685038002223 active site 685038002224 ADP binding site [chemical binding]; other site 685038002225 excinuclease ABC subunit B; Provisional; Region: PRK05298 685038002226 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 685038002227 ATP binding site [chemical binding]; other site 685038002228 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 685038002229 nucleotide binding region [chemical binding]; other site 685038002230 ATP-binding site [chemical binding]; other site 685038002231 Ultra-violet resistance protein B; Region: UvrB; pfam12344 685038002232 UvrB/uvrC motif; Region: UVR; pfam02151 685038002233 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 685038002234 phosphate binding site [ion binding]; other site 685038002235 putative substrate binding pocket [chemical binding]; other site 685038002236 dimer interface [polypeptide binding]; other site 685038002237 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 685038002238 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 685038002239 FeS/SAM binding site; other site 685038002240 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 685038002241 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 685038002242 MPT binding site; other site 685038002243 trimer interface [polypeptide binding]; other site 685038002244 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 685038002245 trimer interface [polypeptide binding]; other site 685038002246 dimer interface [polypeptide binding]; other site 685038002247 putative active site [active] 685038002248 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 685038002249 MoaE interaction surface [polypeptide binding]; other site 685038002250 MoeB interaction surface [polypeptide binding]; other site 685038002251 thiocarboxylated glycine; other site 685038002252 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 685038002253 MoaE homodimer interface [polypeptide binding]; other site 685038002254 MoaD interaction [polypeptide binding]; other site 685038002255 active site residues [active] 685038002256 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 685038002257 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 685038002258 Predicted integral membrane protein [Function unknown]; Region: COG0392 685038002259 cardiolipin synthase 2; Provisional; Region: PRK11263 685038002260 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 685038002261 putative active site [active] 685038002262 catalytic site [active] 685038002263 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 685038002264 putative active site [active] 685038002265 catalytic site [active] 685038002266 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 685038002267 putative catalytic site [active] 685038002268 putative metal binding site [ion binding]; other site 685038002269 putative phosphate binding site [ion binding]; other site 685038002270 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 685038002271 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 685038002272 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 685038002273 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 685038002274 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 685038002275 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 685038002276 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 685038002277 Walker A/P-loop; other site 685038002278 ATP binding site [chemical binding]; other site 685038002279 Q-loop/lid; other site 685038002280 ABC transporter signature motif; other site 685038002281 Walker B; other site 685038002282 D-loop; other site 685038002283 H-loop/switch region; other site 685038002284 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 685038002285 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 685038002286 Walker A/P-loop; other site 685038002287 ATP binding site [chemical binding]; other site 685038002288 Q-loop/lid; other site 685038002289 ABC transporter signature motif; other site 685038002290 Walker B; other site 685038002291 D-loop; other site 685038002292 H-loop/switch region; other site 685038002293 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 685038002294 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 685038002295 HlyD family secretion protein; Region: HlyD_3; pfam13437 685038002296 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 685038002297 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685038002298 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 685038002299 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 685038002300 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 685038002301 ATP binding site [chemical binding]; other site 685038002302 Mg++ binding site [ion binding]; other site 685038002303 motif III; other site 685038002304 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 685038002305 nucleotide binding region [chemical binding]; other site 685038002306 ATP-binding site [chemical binding]; other site 685038002307 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 685038002308 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 685038002309 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 685038002310 glycosyl transferase family protein; Provisional; Region: PRK08136 685038002311 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 685038002312 putative dehydrogenase; Provisional; Region: PRK10098 685038002313 hypothetical protein; Provisional; Region: PRK10259 685038002314 hypothetical protein; Provisional; Region: PRK11019 685038002315 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 685038002316 catecholate siderophore receptor Fiu; Provisional; Region: PRK09840 685038002317 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 685038002318 N-terminal plug; other site 685038002319 ligand-binding site [chemical binding]; other site 685038002320 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 685038002321 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 685038002322 putative mechanosensitive channel protein; Provisional; Region: PRK11465 685038002323 Mechanosensitive ion channel; Region: MS_channel; pfam00924 685038002324 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 685038002325 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 685038002326 Walker A/P-loop; other site 685038002327 ATP binding site [chemical binding]; other site 685038002328 Q-loop/lid; other site 685038002329 ABC transporter signature motif; other site 685038002330 Walker B; other site 685038002331 D-loop; other site 685038002332 H-loop/switch region; other site 685038002333 glutamine ABC transporter permease protein; Reviewed; Region: glnP; PRK09494 685038002334 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685038002335 dimer interface [polypeptide binding]; other site 685038002336 conserved gate region; other site 685038002337 putative PBP binding loops; other site 685038002338 ABC-ATPase subunit interface; other site 685038002339 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 685038002340 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 685038002341 substrate binding pocket [chemical binding]; other site 685038002342 membrane-bound complex binding site; other site 685038002343 hinge residues; other site 685038002344 Ferritin-like domain; Region: Ferritin; pfam00210 685038002345 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 685038002346 dimerization interface [polypeptide binding]; other site 685038002347 DPS ferroxidase diiron center [ion binding]; other site 685038002348 ion pore; other site 685038002349 threonine and homoserine efflux system; Provisional; Region: PRK10532 685038002350 EamA-like transporter family; Region: EamA; pfam00892 685038002351 outer membrane protein X; Provisional; Region: ompX; PRK09408 685038002352 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 685038002353 Sulfatase; Region: Sulfatase; pfam00884 685038002354 manganese transport regulator MntR; Provisional; Region: PRK11050 685038002355 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 685038002356 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742 685038002357 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 685038002358 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 685038002359 transmembrane helices; other site 685038002360 L,D-transpeptidase; Provisional; Region: PRK10260 685038002361 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 685038002362 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 685038002363 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 685038002364 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685038002365 Walker A/P-loop; other site 685038002366 ATP binding site [chemical binding]; other site 685038002367 ABC transporter signature motif; other site 685038002368 Walker B; other site 685038002369 ABC transporter; Region: ABC_tran_2; pfam12848 685038002370 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 685038002371 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 685038002372 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 685038002373 active site 685038002374 motif I; other site 685038002375 motif II; other site 685038002376 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 685038002377 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 685038002378 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 685038002379 dimer interface [polypeptide binding]; other site 685038002380 active site 685038002381 glycine loop; other site 685038002382 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 685038002383 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 685038002384 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 685038002385 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 685038002386 active site 685038002387 intersubunit interactions; other site 685038002388 catalytic residue [active] 685038002389 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 685038002390 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 685038002391 ATP binding site [chemical binding]; other site 685038002392 substrate interface [chemical binding]; other site 685038002393 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 685038002394 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 685038002395 dimer interface [polypeptide binding]; other site 685038002396 putative functional site; other site 685038002397 putative MPT binding site; other site 685038002398 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 685038002399 catalytic nucleophile [active] 685038002400 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 685038002401 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 685038002402 Walker A/P-loop; other site 685038002403 ATP binding site [chemical binding]; other site 685038002404 Q-loop/lid; other site 685038002405 ABC transporter signature motif; other site 685038002406 Walker B; other site 685038002407 D-loop; other site 685038002408 H-loop/switch region; other site 685038002409 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 685038002410 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 685038002411 Walker A/P-loop; other site 685038002412 ATP binding site [chemical binding]; other site 685038002413 Q-loop/lid; other site 685038002414 ABC transporter signature motif; other site 685038002415 Walker B; other site 685038002416 D-loop; other site 685038002417 H-loop/switch region; other site 685038002418 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 685038002419 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 685038002420 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 685038002421 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 685038002422 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685038002423 dimer interface [polypeptide binding]; other site 685038002424 conserved gate region; other site 685038002425 putative PBP binding loops; other site 685038002426 ABC-ATPase subunit interface; other site 685038002427 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 685038002428 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 685038002429 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685038002430 dimer interface [polypeptide binding]; other site 685038002431 conserved gate region; other site 685038002432 putative PBP binding loops; other site 685038002433 ABC-ATPase subunit interface; other site 685038002434 Internal stop codon in common BLAST hit: YP_539853.1 hypothetical protein UTI89_C0836 [Escherichia coli UTI89] 685038002435 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 685038002436 metal binding site [ion binding]; metal-binding site 685038002437 active site 685038002438 I-site; other site 685038002439 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 685038002440 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 685038002441 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 685038002442 FeS/SAM binding site; other site 685038002443 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 685038002444 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 685038002445 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 685038002446 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 685038002447 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 685038002448 putative C-terminal domain interface [polypeptide binding]; other site 685038002449 putative GSH binding site (G-site) [chemical binding]; other site 685038002450 putative dimer interface [polypeptide binding]; other site 685038002451 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 685038002452 N-terminal domain interface [polypeptide binding]; other site 685038002453 dimer interface [polypeptide binding]; other site 685038002454 substrate binding pocket (H-site) [chemical binding]; other site 685038002455 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 685038002456 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 685038002457 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 685038002458 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 685038002459 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 685038002460 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 685038002461 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 685038002462 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 685038002463 active site 685038002464 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 685038002465 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038002466 putative substrate translocation pore; other site 685038002467 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 685038002468 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 685038002469 active site 685038002470 motif I; other site 685038002471 motif II; other site 685038002472 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 685038002473 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 685038002474 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 685038002475 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038002476 putative substrate translocation pore; other site 685038002477 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 685038002478 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685038002479 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 685038002480 putative transporter; Provisional; Region: PRK04972 685038002481 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 685038002482 TrkA-C domain; Region: TrkA_C; pfam02080 685038002483 TrkA-C domain; Region: TrkA_C; pfam02080 685038002484 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 685038002485 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 685038002486 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 685038002487 GSH binding site [chemical binding]; other site 685038002488 catalytic residues [active] 685038002489 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 685038002490 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 685038002491 dimer interface [polypeptide binding]; other site 685038002492 FMN binding site [chemical binding]; other site 685038002493 NADPH bind site [chemical binding]; other site 685038002494 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 685038002495 RimK-like ATP-grasp domain; Region: RimK; pfam08443 685038002496 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 685038002497 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 685038002498 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 685038002499 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685038002500 Walker A/P-loop; other site 685038002501 ATP binding site [chemical binding]; other site 685038002502 Q-loop/lid; other site 685038002503 ABC transporter signature motif; other site 685038002504 Walker B; other site 685038002505 D-loop; other site 685038002506 H-loop/switch region; other site 685038002507 TOBE domain; Region: TOBE_2; pfam08402 685038002508 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685038002509 dimer interface [polypeptide binding]; other site 685038002510 conserved gate region; other site 685038002511 putative PBP binding loops; other site 685038002512 ABC-ATPase subunit interface; other site 685038002513 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 685038002514 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685038002515 dimer interface [polypeptide binding]; other site 685038002516 conserved gate region; other site 685038002517 putative PBP binding loops; other site 685038002518 ABC-ATPase subunit interface; other site 685038002519 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 685038002520 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 685038002521 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685038002522 S-adenosylmethionine binding site [chemical binding]; other site 685038002523 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 685038002524 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 685038002525 substrate binding pocket [chemical binding]; other site 685038002526 membrane-bound complex binding site; other site 685038002527 hinge residues; other site 685038002528 arginine transporter permease subunit ArtM; Provisional; Region: artM; PRK11122 685038002529 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685038002530 dimer interface [polypeptide binding]; other site 685038002531 conserved gate region; other site 685038002532 putative PBP binding loops; other site 685038002533 ABC-ATPase subunit interface; other site 685038002534 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 685038002535 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685038002536 dimer interface [polypeptide binding]; other site 685038002537 conserved gate region; other site 685038002538 putative PBP binding loops; other site 685038002539 ABC-ATPase subunit interface; other site 685038002540 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 685038002541 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 685038002542 substrate binding pocket [chemical binding]; other site 685038002543 membrane-bound complex binding site; other site 685038002544 hinge residues; other site 685038002545 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 685038002546 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685038002547 Walker A/P-loop; other site 685038002548 ATP binding site [chemical binding]; other site 685038002549 Q-loop/lid; other site 685038002550 ABC transporter signature motif; other site 685038002551 Walker B; other site 685038002552 D-loop; other site 685038002553 H-loop/switch region; other site 685038002554 putative lipoprotein; Provisional; Region: PRK10533 685038002555 hypothetical protein; Provisional; Region: PRK02877 685038002556 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 685038002557 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 685038002558 amidase catalytic site [active] 685038002559 Zn binding residues [ion binding]; other site 685038002560 substrate binding site [chemical binding]; other site 685038002561 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 685038002562 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685038002563 NAD(P) binding site [chemical binding]; other site 685038002564 active site 685038002565 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 685038002566 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 685038002567 putative NAD(P) binding site [chemical binding]; other site 685038002568 putative active site [active] 685038002569 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 685038002570 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 685038002571 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 685038002572 tetramer interface [polypeptide binding]; other site 685038002573 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685038002574 catalytic residue [active] 685038002575 pyruvate dehydrogenase; Provisional; Region: PRK09124 685038002576 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 685038002577 PYR/PP interface [polypeptide binding]; other site 685038002578 dimer interface [polypeptide binding]; other site 685038002579 tetramer interface [polypeptide binding]; other site 685038002580 TPP binding site [chemical binding]; other site 685038002581 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 685038002582 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 685038002583 TPP-binding site [chemical binding]; other site 685038002584 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 685038002585 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 685038002586 FAD binding pocket [chemical binding]; other site 685038002587 FAD binding motif [chemical binding]; other site 685038002588 phosphate binding motif [ion binding]; other site 685038002589 beta-alpha-beta structure motif; other site 685038002590 NAD binding pocket [chemical binding]; other site 685038002591 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 685038002592 catalytic loop [active] 685038002593 iron binding site [ion binding]; other site 685038002594 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 685038002595 cubane metal cluster [ion binding]; other site 685038002596 hybrid metal cluster; other site 685038002597 Predicted membrane protein [Function unknown]; Region: COG2431 685038002598 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 685038002599 amphipathic channel; other site 685038002600 Asn-Pro-Ala signature motifs; other site 685038002601 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 685038002602 AAA domain; Region: AAA_21; pfam13304 685038002603 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 685038002604 putative active site [active] 685038002605 putative metal-binding site [ion binding]; other site 685038002606 Protein of unknown function (DUF535); Region: DUF535; pfam04393 685038002607 macrolide transporter subunit MacA; Provisional; Region: PRK11578 685038002608 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 685038002609 HlyD family secretion protein; Region: HlyD_3; pfam13437 685038002610 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 685038002611 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 685038002612 Walker A/P-loop; other site 685038002613 ATP binding site [chemical binding]; other site 685038002614 Q-loop/lid; other site 685038002615 ABC transporter signature motif; other site 685038002616 Walker B; other site 685038002617 D-loop; other site 685038002618 H-loop/switch region; other site 685038002619 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 685038002620 FtsX-like permease family; Region: FtsX; pfam02687 685038002621 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 685038002622 DNA-binding site [nucleotide binding]; DNA binding site 685038002623 RNA-binding motif; other site 685038002624 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 685038002625 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 685038002626 Clp amino terminal domain; Region: Clp_N; pfam02861 685038002627 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685038002628 Walker A motif; other site 685038002629 ATP binding site [chemical binding]; other site 685038002630 Walker B motif; other site 685038002631 arginine finger; other site 685038002632 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685038002633 Walker A motif; other site 685038002634 ATP binding site [chemical binding]; other site 685038002635 Walker B motif; other site 685038002636 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 685038002637 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-F; cd09718 685038002638 CRISPR/Cas system-associated protein Cas3/Cas2; Region: Cas3_Cas2_I-F; cd09673 685038002639 CRISPR-associated helicase Cas3, subtype I-F/YPEST; Region: cas3_yersinia; TIGR02562 685038002640 CRISPR/Cas system-associated protein Csy1; Region: Csy1_I-F; cd09735 685038002641 CRISPR/Cas system-associated RAMP superfamily protein Csy2; Region: Csy2_I-F; cd09736 685038002642 CRISPR/Cas system-associated RAMP superfamily protein Csy3; Region: Csy3_I-F; cd09737 685038002643 CRISPR/Cas system-associated RAMP superfamily protein Cas6f; Region: Cas6_I-F; cd09739 685038002644 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 685038002645 rRNA binding site [nucleotide binding]; other site 685038002646 predicted 30S ribosome binding site; other site 685038002647 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 685038002648 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 685038002649 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 685038002650 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 685038002651 Walker A/P-loop; other site 685038002652 ATP binding site [chemical binding]; other site 685038002653 Q-loop/lid; other site 685038002654 ABC transporter signature motif; other site 685038002655 Walker B; other site 685038002656 D-loop; other site 685038002657 H-loop/switch region; other site 685038002658 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 685038002659 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 685038002660 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685038002661 Walker A/P-loop; other site 685038002662 ATP binding site [chemical binding]; other site 685038002663 Q-loop/lid; other site 685038002664 ABC transporter signature motif; other site 685038002665 Walker B; other site 685038002666 D-loop; other site 685038002667 H-loop/switch region; other site 685038002668 thioredoxin reductase; Provisional; Region: PRK10262 685038002669 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 685038002670 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 685038002671 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 685038002672 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 685038002673 putative DNA binding site [nucleotide binding]; other site 685038002674 putative Zn2+ binding site [ion binding]; other site 685038002675 AsnC family; Region: AsnC_trans_reg; pfam01037 685038002676 DNA translocase FtsK; Provisional; Region: PRK10263 685038002677 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 685038002678 hypothetical protein; Provisional; Region: PHA03160 685038002679 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 685038002680 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 685038002681 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 685038002682 periplasmic chaperone LolA; Region: lolA; TIGR00547 685038002683 recombination factor protein RarA; Reviewed; Region: PRK13342 685038002684 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685038002685 Walker A motif; other site 685038002686 ATP binding site [chemical binding]; other site 685038002687 Walker B motif; other site 685038002688 arginine finger; other site 685038002689 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 685038002690 seryl-tRNA synthetase; Provisional; Region: PRK05431 685038002691 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 685038002692 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 685038002693 dimer interface [polypeptide binding]; other site 685038002694 active site 685038002695 motif 1; other site 685038002696 motif 2; other site 685038002697 motif 3; other site 685038002698 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 685038002699 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 685038002700 putative [Fe4-S4] binding site [ion binding]; other site 685038002701 putative molybdopterin cofactor binding site [chemical binding]; other site 685038002702 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 685038002703 putative molybdopterin cofactor binding site; other site 685038002704 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 685038002705 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 685038002706 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 685038002707 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 685038002708 catalytic triad [active] 685038002709 dimer interface [polypeptide binding]; other site 685038002710 conserved cis-peptide bond; other site 685038002711 putative MFS family transporter protein; Provisional; Region: PRK03633 685038002712 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038002713 putative substrate translocation pore; other site 685038002714 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 685038002715 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 685038002716 FeS/SAM binding site; other site 685038002717 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 685038002718 Pyruvate formate lyase 1; Region: PFL1; cd01678 685038002719 coenzyme A binding site [chemical binding]; other site 685038002720 active site 685038002721 catalytic residues [active] 685038002722 glycine loop; other site 685038002723 formate transporter; Provisional; Region: PRK10805 685038002724 uncharacterized domain; Region: TIGR00702 685038002725 Predicted membrane protein [Function unknown]; Region: COG2323 685038002726 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 685038002727 homodimer interface [polypeptide binding]; other site 685038002728 substrate-cofactor binding pocket; other site 685038002729 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685038002730 catalytic residue [active] 685038002731 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 685038002732 Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554 685038002733 hinge; other site 685038002734 active site 685038002735 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 685038002736 cytidylate kinase; Provisional; Region: cmk; PRK00023 685038002737 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 685038002738 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 685038002739 active site 685038002740 CMP-binding site; other site 685038002741 The sites determining sugar specificity; other site 685038002742 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 685038002743 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 685038002744 RNA binding site [nucleotide binding]; other site 685038002745 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 685038002746 RNA binding site [nucleotide binding]; other site 685038002747 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 685038002748 RNA binding site [nucleotide binding]; other site 685038002749 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 685038002750 RNA binding site [nucleotide binding]; other site 685038002751 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 685038002752 RNA binding site [nucleotide binding]; other site 685038002753 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 685038002754 RNA binding site [nucleotide binding]; other site 685038002755 Beta subunit of integration host factor (IHFB); Region: IHF_B; cd13836 685038002756 dimer interface [polypeptide binding]; other site 685038002757 DNA binding site [nucleotide binding] 685038002758 ComEC family competence protein; Provisional; Region: PRK11539 685038002759 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 685038002760 ComEC/Rec2-related protein; Region: ComEC_N-term; TIGR00360 685038002761 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 685038002762 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 685038002763 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 685038002764 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 685038002765 Walker A/P-loop; other site 685038002766 ATP binding site [chemical binding]; other site 685038002767 Q-loop/lid; other site 685038002768 ABC transporter signature motif; other site 685038002769 Walker B; other site 685038002770 D-loop; other site 685038002771 H-loop/switch region; other site 685038002772 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 685038002773 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 685038002774 hypothetical protein; Provisional; Region: PRK11827 685038002775 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 685038002776 Ligand binding site; other site 685038002777 oligomer interface; other site 685038002778 hypothetical protein; Provisional; Region: PRK10593 685038002779 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 685038002780 putative active site [active] 685038002781 Methyltransferase domain; Region: Methyltransf_31; pfam13847 685038002782 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685038002783 S-adenosylmethionine binding site [chemical binding]; other site 685038002784 condesin subunit F; Provisional; Region: PRK05260 685038002785 condesin subunit E; Provisional; Region: PRK05256 685038002786 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 685038002787 MukB N-terminal; Region: MukB; pfam04310 685038002788 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 685038002789 murein L,D-transpeptidase; Provisional; Region: PRK10594 685038002790 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 685038002791 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 685038002792 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 685038002793 Peptidase M15; Region: Peptidase_M15_3; cl01194 685038002794 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 685038002795 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 685038002796 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 685038002797 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685038002798 homodimer interface [polypeptide binding]; other site 685038002799 catalytic residue [active] 685038002800 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 685038002801 trimer interface [polypeptide binding]; other site 685038002802 eyelet of channel; other site 685038002803 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 685038002804 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 685038002805 putative dimer interface [polypeptide binding]; other site 685038002806 putative anticodon binding site; other site 685038002807 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 685038002808 homodimer interface [polypeptide binding]; other site 685038002809 motif 1; other site 685038002810 motif 2; other site 685038002811 active site 685038002812 motif 3; other site 685038002813 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 685038002814 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 685038002815 active site 685038002816 aminopeptidase N; Provisional; Region: pepN; PRK14015 685038002817 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 685038002818 active site 685038002819 Zn binding site [ion binding]; other site 685038002820 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 685038002821 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 685038002822 Walker A/P-loop; other site 685038002823 ATP binding site [chemical binding]; other site 685038002824 Q-loop/lid; other site 685038002825 ABC transporter signature motif; other site 685038002826 Walker B; other site 685038002827 D-loop; other site 685038002828 H-loop/switch region; other site 685038002829 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 685038002830 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685038002831 dimer interface [polypeptide binding]; other site 685038002832 conserved gate region; other site 685038002833 putative PBP binding loops; other site 685038002834 ABC-ATPase subunit interface; other site 685038002835 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 685038002836 active site 685038002837 dimer interface [polypeptide binding]; other site 685038002838 non-prolyl cis peptide bond; other site 685038002839 insertion regions; other site 685038002840 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 685038002841 substrate binding pocket [chemical binding]; other site 685038002842 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 685038002843 membrane-bound complex binding site; other site 685038002844 hinge residues; other site 685038002845 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 685038002846 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 685038002847 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 685038002848 quinone interaction residues [chemical binding]; other site 685038002849 active site 685038002850 catalytic residues [active] 685038002851 FMN binding site [chemical binding]; other site 685038002852 substrate binding site [chemical binding]; other site 685038002853 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 685038002854 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 685038002855 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 685038002856 MOSC domain; Region: MOSC; pfam03473 685038002857 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 685038002858 catalytic loop [active] 685038002859 iron binding site [ion binding]; other site 685038002860 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 685038002861 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 685038002862 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 685038002863 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685038002864 S-adenosylmethionine binding site [chemical binding]; other site 685038002865 ABC transporter ATPase component; Reviewed; Region: PRK11147 685038002866 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 685038002867 ABC transporter; Region: ABC_tran_2; pfam12848 685038002868 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 685038002869 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 685038002870 Paraquat-inducible protein A; Region: PqiA; pfam04403 685038002871 Paraquat-inducible protein A; Region: PqiA; pfam04403 685038002872 paraquat-inducible protein B; Provisional; Region: PRK10807 685038002873 mce related protein; Region: MCE; pfam02470 685038002874 mce related protein; Region: MCE; pfam02470 685038002875 mce related protein; Region: MCE; pfam02470 685038002876 DASH complex subunit Duo1; Region: DASH_Duo1; pfam08651 685038002877 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 685038002878 ribosome modulation factor; Provisional; Region: PRK14563 685038002879 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 685038002880 active site 1 [active] 685038002881 dimer interface [polypeptide binding]; other site 685038002882 active site 2 [active] 685038002883 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 685038002884 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 685038002885 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 685038002886 outer membrane protein A; Reviewed; Region: PRK10808 685038002887 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 685038002888 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 685038002889 ligand binding site [chemical binding]; other site 685038002890 cell division inhibitor SulA; Region: sula; TIGR00623 685038002891 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 685038002892 TfoX C-terminal domain; Region: TfoX_C; pfam04994 685038002893 TIGR01666 family membrane protein; Region: YCCS 685038002894 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 685038002895 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 685038002896 Predicted membrane protein [Function unknown]; Region: COG3304 685038002897 Domain of unknown function (DUF307); Region: DUF307; pfam03733 685038002898 Domain of unknown function (DUF307); Region: DUF307; pfam03733 685038002899 DNA helicase IV; Provisional; Region: helD; PRK11054 685038002900 DNA helicase IV / RNA helicase N terminal; Region: Helicase_IV_N; pfam12462 685038002901 Part of AAA domain; Region: AAA_19; pfam13245 685038002902 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 685038002903 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 685038002904 active site 685038002905 dimer interfaces [polypeptide binding]; other site 685038002906 catalytic residues [active] 685038002907 hypothetical protein; Provisional; Region: PRK03641 685038002908 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 685038002909 heat shock protein HspQ; Provisional; Region: PRK14129 685038002910 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 685038002911 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 685038002912 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 685038002913 putative RNA binding site [nucleotide binding]; other site 685038002914 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685038002915 S-adenosylmethionine binding site [chemical binding]; other site 685038002916 Acylphosphatase; Region: Acylphosphatase; cl00551 685038002917 sulfur transfer protein TusE; Provisional; Region: PRK11508 685038002918 YccA-like proteins; Region: YccA_like; cd10433 685038002919 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 685038002920 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 685038002921 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 685038002922 NiFe/NiFeSe hydrogenase small subunit C-terminal; Region: NiFe_hyd_SSU_C; pfam14720 685038002923 hydrogenase 1 large subunit; Provisional; Region: PRK10170 685038002924 hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171 685038002925 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 685038002926 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 685038002927 putative substrate-binding site; other site 685038002928 nickel binding site [ion binding]; other site 685038002929 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 685038002930 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 685038002931 cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035 685038002932 cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028 685038002933 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 685038002934 hypothetical protein; Provisional; Region: PRK14749 685038002935 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 685038002936 catalytic core [active] 685038002937 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 685038002938 DNA-binding site [nucleotide binding]; DNA binding site 685038002939 RNA-binding motif; other site 685038002940 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 685038002941 DNA-binding site [nucleotide binding]; DNA binding site 685038002942 RNA-binding motif; other site 685038002943 cold shock gene; Provisional; Region: PRK09891 685038002944 GnsA/GnsB family; Region: GnsAB; pfam08178 685038002945 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 685038002946 4Fe-4S binding domain; Region: Fer4_5; pfam12801 685038002947 4Fe-4S binding domain; Region: Fer4_5; pfam12801 685038002948 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 685038002949 hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466 685038002950 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 685038002951 dimerization interface [polypeptide binding]; other site 685038002952 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 685038002953 dimer interface [polypeptide binding]; other site 685038002954 phosphorylation site [posttranslational modification] 685038002955 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685038002956 ATP binding site [chemical binding]; other site 685038002957 Mg2+ binding site [ion binding]; other site 685038002958 G-X-G motif; other site 685038002959 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685038002960 active site 685038002961 phosphorylation site [posttranslational modification] 685038002962 intermolecular recognition site; other site 685038002963 dimerization interface [polypeptide binding]; other site 685038002964 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 685038002965 putative binding surface; other site 685038002966 active site 685038002967 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 685038002968 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 685038002969 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_1; cl12235 685038002970 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 685038002971 dimer interface [polypeptide binding]; other site 685038002972 active site 685038002973 Int/Topo IB signature motif; other site 685038002974 Excisionase-like protein; Region: Exc; pfam07825 685038002975 ASCH domain; Region: ASCH; pfam04266 685038002976 Protein of unknown function (DUF551); Region: DUF551; pfam04448 685038002977 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 685038002978 Protein of unknown function (DUF2737); Region: DUF2737; pfam10930 685038002979 Protein of unknown function (DUF2856); Region: DUF2856; pfam11043 685038002980 ERF superfamily; Region: ERF; pfam04404 685038002981 Bacteriophage lambda Kil protein; Region: Lambda_Kil; pfam06301 685038002982 Lambda Phage CIII; Region: Lambda_CIII; pfam02061 685038002983 Violaxanthin de-epoxidase (VDE); Region: VDE; cl06253 685038002984 Superinfection exclusion protein B; Region: SieB; pfam14163 685038002985 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 685038002986 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 685038002987 non-specific DNA binding site [nucleotide binding]; other site 685038002988 salt bridge; other site 685038002989 sequence-specific DNA binding site [nucleotide binding]; other site 685038002990 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 685038002991 Catalytic site [active] 685038002992 DNA-binding transcriptional regulator Cro; Region: P22_Cro; pfam14549 685038002993 Bacteriophage CII protein; Region: Phage_CII; pfam05269 685038002994 Bacteriophage replication protein O; Region: Phage_rep_O; cl04545 685038002995 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 685038002996 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 685038002997 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 685038002998 Walker A motif; other site 685038002999 ATP binding site [chemical binding]; other site 685038003000 Walker B motif; other site 685038003001 DNA binding loops [nucleotide binding] 685038003002 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 685038003003 NinB protein; Region: NinB; pfam05772 685038003004 NINE Protein; Region: NinE; pfam05322 685038003005 Protein of unknown function (DUF2591); Region: DUF2591; pfam10765 685038003006 NinF protein; Region: NinF; pfam05810 685038003007 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 685038003008 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 685038003009 Protein of unknown function (DUF1364); Region: DUF1364; pfam07102 685038003010 Endodeoxyribonuclease RusA; Region: RusA; cl01885 685038003011 Phage NinH protein; Region: Phage_NinH; pfam06322 685038003012 Antitermination protein; Region: Antiterm; pfam03589 685038003013 Antitermination protein; Region: Antiterm; pfam03589 685038003014 phage holin, lambda family; Region: holin_lambda; TIGR01594 685038003015 The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes. But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736 685038003016 N-acetyl-D-glucosamine binding site [chemical binding]; other site 685038003017 catalytic residue [active] 685038003018 Bacteriophage Rz lysis protein; Region: Phage_lysis; pfam03245 685038003019 hypothetical protein; Region: PHA01971 685038003020 Protein of unknown function (DUF2560); Region: DUF2560; pfam10834 685038003021 Terminase-like family; Region: Terminase_6; pfam03237 685038003022 Bacteriophage terminase large (ATPase) subunit and inactivated derivatives [General function prediction only]; Region: COG5565 685038003023 HemX; Region: HemX; cl19375 685038003024 Bacteriophage, scaffolding protein; Region: Phage-scaffold; pfam09306 685038003025 P22 coat protein - gene protein 5; Region: P22_CoatProtein; cl19542 685038003026 P22 tail accessory factor; Region: P22_Tail-4; pfam11650 685038003027 Phage stabilisation protein; Region: Phage_stabilize; pfam11134 685038003028 endonuclease subunit; Provisional; Region: 46; PHA02562 685038003029 Protein of unknown function (DUF2824); Region: DUF2824; pfam11039 685038003030 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 685038003031 PEGA domain; Region: PEGA; pfam08308 685038003032 Arc-like DNA binding domain; Region: Arc; pfam03869 685038003033 Mnt; Region: mnt; PHA01513 685038003034 Arc-like DNA binding domain; Region: Arc; pfam03869 685038003035 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 685038003036 Phage anti-repressor protein [Transcription]; Region: COG3561 685038003037 HNH endonuclease; Region: HNH_3; pfam13392 685038003038 AP2 domain; Region: AP2; pfam00847 685038003039 Head binding; Region: Head_binding; pfam09008 685038003040 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 685038003041 TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306 685038003042 putative ligand binding site [chemical binding]; other site 685038003043 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 685038003044 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685038003045 active site 685038003046 phosphorylation site [posttranslational modification] 685038003047 intermolecular recognition site; other site 685038003048 dimerization interface [polypeptide binding]; other site 685038003049 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 685038003050 DNA binding site [nucleotide binding] 685038003051 trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032 685038003052 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 685038003053 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 685038003054 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 685038003055 molybdopterin cofactor binding site [chemical binding]; other site 685038003056 substrate binding site [chemical binding]; other site 685038003057 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 685038003058 molybdopterin cofactor binding site; other site 685038003059 chaperone protein TorD; Validated; Region: torD; PRK04976 685038003060 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 685038003061 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 685038003062 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 685038003063 HSP70 interaction site [polypeptide binding]; other site 685038003064 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 685038003065 substrate binding site [polypeptide binding]; other site 685038003066 dimer interface [polypeptide binding]; other site 685038003067 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 685038003068 catalytic core [active] 685038003069 hypothetical protein; Provisional; Region: PRK10174 685038003070 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 685038003071 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 685038003072 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 685038003073 uracil-xanthine permease; Region: ncs2; TIGR00801 685038003074 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 685038003075 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 685038003076 putative FMN binding site [chemical binding]; other site 685038003077 pyrimidine utilization protein D; Region: RutD; TIGR03611 685038003078 Putative lysophospholipase; Region: Hydrolase_4; cl19140 685038003079 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 685038003080 homotrimer interaction site [polypeptide binding]; other site 685038003081 putative active site [active] 685038003082 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 685038003083 catalytic triad [active] 685038003084 conserved cis-peptide bond; other site 685038003085 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 685038003086 active site 685038003087 dimer interface [polypeptide binding]; other site 685038003088 non-prolyl cis peptide bond; other site 685038003089 insertion regions; other site 685038003090 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 685038003091 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685038003092 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 685038003093 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 685038003094 Predicted transcriptional regulator [Transcription]; Region: COG3905 685038003095 DNA-binding domain of Proline dehydrogenase; Region: Pro_dh-DNA_bdg; pfam14850 685038003096 Proline dehydrogenase; Region: Pro_dh; pfam01619 685038003097 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 685038003098 Glutamate binding site [chemical binding]; other site 685038003099 NAD binding site [chemical binding]; other site 685038003100 catalytic residues [active] 685038003101 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 685038003102 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 685038003103 Na binding site [ion binding]; other site 685038003104 FTR1 family protein; Region: TIGR00145 685038003105 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 685038003106 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 685038003107 Imelysin; Region: Peptidase_M75; pfam09375 685038003108 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 685038003109 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 685038003110 hypothetical protein; Provisional; Region: PRK10536 685038003111 putative PGA biosynthesis protein; Provisional; Region: pgaD; PRK14585 685038003112 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 685038003113 N-glycosyltransferase; Provisional; Region: PRK11204 685038003114 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 685038003115 DXD motif; other site 685038003116 outer membrane N-deacetylase; Provisional; Region: pgaB; PRK14582 685038003117 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 685038003118 putative active site [active] 685038003119 putative metal binding site [ion binding]; other site 685038003120 Hypothetical glycosyl hydrolase family 13; Region: GHL13; pfam14883 685038003121 outer membrane protein PgaA; Provisional; Region: pgaA; PRK10049 685038003122 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 685038003123 metal binding site [ion binding]; metal-binding site 685038003124 active site 685038003125 I-site; other site 685038003126 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 685038003127 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 685038003128 putative ligand binding site [chemical binding]; other site 685038003129 NAD binding site [chemical binding]; other site 685038003130 dimerization interface [polypeptide binding]; other site 685038003131 catalytic site [active] 685038003132 putative hydrolase; Validated; Region: PRK09248 685038003133 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 685038003134 active site 685038003135 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 685038003136 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 685038003137 curli production assembly/transport protein CsgG; Provisional; Region: PRK15184 685038003138 curli assembly protein CsgF; Provisional; Region: PRK10050 685038003139 curli assembly protein CsgE; Provisional; Region: PRK10386 685038003140 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 685038003141 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 685038003142 DNA binding residues [nucleotide binding] 685038003143 dimerization interface [polypeptide binding]; other site 685038003144 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 685038003145 Curlin associated repeat; Region: Curlin_rpt; pfam07012 685038003146 Curlin associated repeat; Region: Curlin_rpt; pfam07012 685038003147 major curlin subunit; Provisional; Region: csgA; PRK10051 685038003148 Thin aggregative fimbriae synthesis protein; Region: Tafi-CsgC; pfam10610 685038003149 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 685038003150 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 685038003151 putative ADP-ribose binding site [chemical binding]; other site 685038003152 putative active site [active] 685038003153 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 685038003154 PLD-like domain; Region: PLDc_2; pfam13091 685038003155 putative active site [active] 685038003156 catalytic site [active] 685038003157 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 685038003158 PLD-like domain; Region: PLDc_2; pfam13091 685038003159 putative active site [active] 685038003160 catalytic site [active] 685038003161 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 685038003162 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 685038003163 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 685038003164 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 685038003165 Ligand binding site; other site 685038003166 DXD motif; other site 685038003167 lipoprotein; Provisional; Region: PRK10175 685038003168 secY/secA suppressor protein; Provisional; Region: PRK11467 685038003169 drug efflux system protein MdtG; Provisional; Region: PRK09874 685038003170 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038003171 putative substrate translocation pore; other site 685038003172 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 685038003173 putative acyl-acceptor binding pocket; other site 685038003174 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 685038003175 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 685038003176 active site residue [active] 685038003177 hypothetical protein; Provisional; Region: PRK03757 685038003178 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 685038003179 Protein of unknown function (DUF2770); Region: DUF2770; pfam10968 685038003180 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 685038003181 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 685038003182 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 685038003183 DNA damage-inducible protein I; Provisional; Region: PRK10597 685038003184 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 685038003185 active site 685038003186 substrate binding pocket [chemical binding]; other site 685038003187 dimer interface [polypeptide binding]; other site 685038003188 lipoprotein; Provisional; Region: PRK10598 685038003189 glutaredoxin 2; Provisional; Region: PRK10387 685038003190 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 685038003191 C-terminal domain interface [polypeptide binding]; other site 685038003192 GSH binding site (G-site) [chemical binding]; other site 685038003193 catalytic residues [active] 685038003194 putative dimer interface [polypeptide binding]; other site 685038003195 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 685038003196 N-terminal domain interface [polypeptide binding]; other site 685038003197 multidrug resistance protein MdtH; Provisional; Region: PRK11646 685038003198 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038003199 putative substrate translocation pore; other site 685038003200 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 685038003201 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 685038003202 hypothetical protein; Provisional; Region: PRK11239 685038003203 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 685038003204 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 685038003205 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 685038003206 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 685038003207 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 685038003208 FlgN protein; Region: FlgN; cl09176 685038003209 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 685038003210 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 685038003211 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 685038003212 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 685038003213 flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173 685038003214 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 685038003215 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 685038003216 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 685038003217 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 685038003218 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 685038003219 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 685038003220 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 685038003221 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 685038003222 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 685038003223 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 685038003224 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787 685038003225 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 685038003226 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 685038003227 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 685038003228 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 685038003229 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 685038003230 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 685038003231 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 685038003232 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 685038003233 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 685038003234 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 685038003235 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 685038003236 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 685038003237 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 685038003238 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 685038003239 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 685038003240 ribonuclease E; Reviewed; Region: rne; PRK10811 685038003241 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 685038003242 homodimer interface [polypeptide binding]; other site 685038003243 oligonucleotide binding site [chemical binding]; other site 685038003244 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 685038003245 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 685038003246 Protein of unknown function (DUF2655); Region: DUF2655; pfam10848 685038003247 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 685038003248 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 685038003249 RNA binding surface [nucleotide binding]; other site 685038003250 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 685038003251 active site 685038003252 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 685038003253 active site 685038003254 dimer interface [polypeptide binding]; other site 685038003255 hypothetical protein; Provisional; Region: PRK11193 685038003256 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 685038003257 putative phosphate acyltransferase; Provisional; Region: PRK05331 685038003258 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 685038003259 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 685038003260 dimer interface [polypeptide binding]; other site 685038003261 active site 685038003262 CoA binding pocket [chemical binding]; other site 685038003263 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 685038003264 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 685038003265 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 685038003266 NAD(P) binding site [chemical binding]; other site 685038003267 homotetramer interface [polypeptide binding]; other site 685038003268 homodimer interface [polypeptide binding]; other site 685038003269 active site 685038003270 acyl carrier protein; Provisional; Region: acpP; PRK00982 685038003271 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 685038003272 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 685038003273 dimer interface [polypeptide binding]; other site 685038003274 active site 685038003275 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 685038003276 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685038003277 catalytic residue [active] 685038003278 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 685038003279 dimerization interface [polypeptide binding]; other site 685038003280 thymidylate kinase; Validated; Region: tmk; PRK00698 685038003281 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 685038003282 TMP-binding site; other site 685038003283 ATP-binding site [chemical binding]; other site 685038003284 DNA polymerase III subunit delta'; Validated; Region: PRK07993 685038003285 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 685038003286 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 685038003287 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 685038003288 active site 685038003289 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 685038003290 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 685038003291 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 685038003292 active site turn [active] 685038003293 phosphorylation site [posttranslational modification] 685038003294 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 685038003295 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 685038003296 N-terminal plug; other site 685038003297 ligand-binding site [chemical binding]; other site 685038003298 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 685038003299 nucleotide binding site/active site [active] 685038003300 HIT family signature motif; other site 685038003301 catalytic residue [active] 685038003302 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 685038003303 putative dimer interface [polypeptide binding]; other site 685038003304 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 685038003305 Phosphotransferase enzyme family; Region: APH; pfam01636 685038003306 active site 685038003307 substrate binding site [chemical binding]; other site 685038003308 ATP binding site [chemical binding]; other site 685038003309 thiamine kinase; Provisional; Region: thiK; PRK10271 685038003310 beta-hexosaminidase; Provisional; Region: PRK05337 685038003311 hypothetical protein; Provisional; Region: PRK04940 685038003312 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 685038003313 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 685038003314 hypothetical protein; Provisional; Region: PRK11280 685038003315 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685038003316 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685038003317 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 685038003318 L,D-transpeptidase; Provisional; Region: PRK10260 685038003319 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 685038003320 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 685038003321 transcription-repair coupling factor; Provisional; Region: PRK10689 685038003322 Bifunctional transglycosylase second domain; Region: UB2H; pfam14814 685038003323 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 685038003324 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 685038003325 ATP binding site [chemical binding]; other site 685038003326 putative Mg++ binding site [ion binding]; other site 685038003327 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 685038003328 nucleotide binding region [chemical binding]; other site 685038003329 ATP-binding site [chemical binding]; other site 685038003330 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 685038003331 Predicted membrane protein [Function unknown]; Region: COG4763 685038003332 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 685038003333 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 685038003334 FtsX-like permease family; Region: FtsX; pfam02687 685038003335 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 685038003336 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 685038003337 Walker A/P-loop; other site 685038003338 ATP binding site [chemical binding]; other site 685038003339 Q-loop/lid; other site 685038003340 ABC transporter signature motif; other site 685038003341 Walker B; other site 685038003342 D-loop; other site 685038003343 H-loop/switch region; other site 685038003344 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 685038003345 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 685038003346 FtsX-like permease family; Region: FtsX; pfam02687 685038003347 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 685038003348 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 685038003349 nucleotide binding site [chemical binding]; other site 685038003350 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 685038003351 NAD+ binding site [chemical binding]; other site 685038003352 substrate binding site [chemical binding]; other site 685038003353 Zn binding site [ion binding]; other site 685038003354 TLP18.3, Psb32 and MOLO-1 founding proteins of phosphatase; Region: TPM; cl01535 685038003355 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 685038003356 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 685038003357 spermidine/putrescine ABC transporter membrane protein; Reviewed; Region: potC; PRK09500 685038003358 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685038003359 dimer interface [polypeptide binding]; other site 685038003360 conserved gate region; other site 685038003361 putative PBP binding loops; other site 685038003362 ABC-ATPase subunit interface; other site 685038003363 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 685038003364 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685038003365 dimer interface [polypeptide binding]; other site 685038003366 conserved gate region; other site 685038003367 putative PBP binding loops; other site 685038003368 ABC-ATPase subunit interface; other site 685038003369 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 685038003370 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 685038003371 Walker A/P-loop; other site 685038003372 ATP binding site [chemical binding]; other site 685038003373 Q-loop/lid; other site 685038003374 ABC transporter signature motif; other site 685038003375 Walker B; other site 685038003376 D-loop; other site 685038003377 H-loop/switch region; other site 685038003378 TOBE domain; Region: TOBE_2; pfam08402 685038003379 peptidase T-like protein; Region: PepT-like; TIGR01883 685038003380 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 685038003381 metal binding site [ion binding]; metal-binding site 685038003382 dimer interface [polypeptide binding]; other site 685038003383 Uncharacterized conserved protein [Function unknown]; Region: COG2850 685038003384 sensor protein PhoQ; Provisional; Region: PRK10815 685038003385 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 685038003386 HAMP domain; Region: HAMP; pfam00672 685038003387 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 685038003388 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685038003389 ATP binding site [chemical binding]; other site 685038003390 Mg2+ binding site [ion binding]; other site 685038003391 G-X-G motif; other site 685038003392 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 685038003393 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685038003394 active site 685038003395 phosphorylation site [posttranslational modification] 685038003396 intermolecular recognition site; other site 685038003397 dimerization interface [polypeptide binding]; other site 685038003398 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 685038003399 DNA binding site [nucleotide binding] 685038003400 adenylosuccinate lyase; Provisional; Region: PRK09285 685038003401 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 685038003402 tetramer interface [polypeptide binding]; other site 685038003403 active site 685038003404 putative lysogenization regulator; Reviewed; Region: PRK00218 685038003405 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 685038003406 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 685038003407 Ligand Binding Site [chemical binding]; other site 685038003408 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 685038003409 nudix motif; other site 685038003410 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 685038003411 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 685038003412 probable active site [active] 685038003413 isocitrate dehydrogenase; Reviewed; Region: PRK07006 685038003414 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 685038003415 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 685038003416 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 685038003417 dimer interface [polypeptide binding]; other site 685038003418 active site 685038003419 Int/Topo IB signature motif; other site 685038003420 Excisionase-like protein; Region: Exc; pfam07825 685038003421 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 685038003422 DksA-like zinc finger domain containing protein; Region: PHA00080 685038003423 Protein of unknown function (DUF1382); Region: DUF1382; pfam07131 685038003424 Protein of unknown function (DUF1317); Region: DUF1317; pfam07026 685038003425 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 685038003426 phage recombination protein Bet; Region: bet_lambda; TIGR01913 685038003427 Host-nuclease inhibitor protein Gam; Region: Gam; pfam06064 685038003428 FtsZ inhibitor protein; Reviewed; Region: kil; PRK11354 685038003429 Uncharacterized conserved protein [Function unknown]; Region: COG4933 685038003430 Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins; Region: DHR2_DOCK; cl06123 685038003431 Rac/Cdc42 binding site [polypeptide binding]; other site 685038003432 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 685038003433 Predicted transcriptional regulator [Transcription]; Region: COG2932 685038003434 sequence-specific DNA binding site [nucleotide binding]; other site 685038003435 salt bridge; other site 685038003436 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 685038003437 Catalytic site [active] 685038003438 DNA-binding transcriptional regulator Cro; Region: P22_Cro; cl18770 685038003439 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 685038003440 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 685038003441 Replication protein P; Region: Phage_lambda_P; pfam06992 685038003442 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 685038003443 putative Zn2+ binding site [ion binding]; other site 685038003444 putative DNA binding site [nucleotide binding]; other site 685038003445 multidrug efflux protein; Reviewed; Region: emrE; PRK09541 685038003446 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 685038003447 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 685038003448 catalytic residues [active] 685038003449 catalytic nucleophile [active] 685038003450 Recombinase; Region: Recombinase; pfam07508 685038003451 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 685038003452 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 685038003453 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 685038003454 hypothetical protein; Provisional; Region: PRK09741 685038003455 prophage protein NinE; Provisional; Region: PRK09689 685038003456 Protein of unknown function (DUF1364); Region: DUF1364; pfam07102 685038003457 endodeoxyribonuclease RUS; Reviewed; Region: PRK09786 685038003458 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 685038003459 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 685038003460 trimer interface [polypeptide binding]; other site 685038003461 eyelet of channel; other site 685038003462 Lysis protein S; Region: Lysis_S; pfam04971 685038003463 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 685038003464 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 685038003465 catalytic residues [active] 685038003466 Bacteriophage Rz lysis protein; Region: Phage_lysis; pfam03245 685038003467 Bor protein; Region: Lambda_Bor; pfam06291 685038003468 Gram-negative bacterial TonB protein C-terminal; Region: TonB_C; pfam03544 685038003469 Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471 685038003470 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 685038003471 gpW; Region: gpW; pfam02831 685038003472 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 685038003473 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 685038003474 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 685038003475 tandem repeat interface [polypeptide binding]; other site 685038003476 oligomer interface [polypeptide binding]; other site 685038003477 active site residues [active] 685038003478 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 685038003479 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 685038003480 integrase; Provisional; Region: PRK09692 685038003481 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 685038003482 active site 685038003483 Int/Topo IB signature motif; other site 685038003484 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 685038003485 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 685038003486 D5 N terminal like; Region: D5_N; smart00885 685038003487 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 685038003488 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 685038003489 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 685038003490 ssDNA binding site [nucleotide binding]; other site 685038003491 dimer interface [polypeptide binding]; other site 685038003492 tetramer (dimer of dimers) interface [polypeptide binding]; other site 685038003493 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 685038003494 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 685038003495 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 685038003496 Protein of unknown function DUF262; Region: DUF262; pfam03235 685038003497 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 685038003498 DNA packaging protein FI; Region: Packaging_FI; pfam14000 685038003499 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 685038003500 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 685038003501 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 685038003502 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 685038003503 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 685038003504 phage minor tail protein G; Region: phage_lambda_G; TIGR01674 685038003505 Minor tail protein T; Region: Phage_tail_T; pfam06223 685038003506 Phage-related minor tail protein [Function unknown]; Region: COG5281 685038003507 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 685038003508 phage tail tape measure protein, lambda family; Region: tape_meas_lam_C; TIGR01541 685038003509 Phage-related protein [Function unknown]; Region: COG4718 685038003510 Phage-related protein [Function unknown]; Region: gp18; COG4672 685038003511 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 685038003512 MPN+ (JAMM) motif; other site 685038003513 Zinc-binding site [ion binding]; other site 685038003514 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 685038003515 NlpC/P60 family; Region: NLPC_P60; cl17555 685038003516 Phage-related protein, tail component [Function unknown]; Region: COG4723 685038003517 Phage-related protein, tail component [Function unknown]; Region: COG4733 685038003518 Putative phage tail protein; Region: Phage-tail_3; pfam13550 685038003519 Fibronectin type 3 domain; Region: FN3; smart00060 685038003520 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 685038003521 Fibronectin type III protein; Region: DUF3672; pfam12421 685038003522 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 685038003523 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 685038003524 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 685038003525 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 685038003526 ABC-ATPase subunit interface; other site 685038003527 dimer interface [polypeptide binding]; other site 685038003528 putative PBP binding regions; other site 685038003529 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 685038003530 ABC-ATPase subunit interface; other site 685038003531 dimer interface [polypeptide binding]; other site 685038003532 putative PBP binding regions; other site 685038003533 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 685038003534 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 685038003535 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 685038003536 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 685038003537 metal binding site [ion binding]; metal-binding site 685038003538 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 685038003539 Phage envelope protein [General function prediction only]; Region: COG5562 685038003540 transcriptional regulator MirA; Provisional; Region: PRK15043 685038003541 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 685038003542 DNA binding residues [nucleotide binding] 685038003543 Sensors of blue-light using FAD; Region: BLUF; smart01034 685038003544 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 685038003545 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 685038003546 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 685038003547 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 685038003548 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 685038003549 Glycine-zipper containing OmpA-like membrane domain; Region: Gly-zipper_OmpA; pfam13436 685038003550 Autotransporter beta-domain; Region: Autotransporter; smart00869 685038003551 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 685038003552 cell division inhibitor MinD; Provisional; Region: PRK10818 685038003553 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 685038003554 P-loop; other site 685038003555 ADP binding residues [chemical binding]; other site 685038003556 Switch I; other site 685038003557 Switch II; other site 685038003558 septum formation inhibitor; Reviewed; Region: minC; PRK03511 685038003559 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 685038003560 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 685038003561 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 685038003562 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 685038003563 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 685038003564 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 685038003565 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 685038003566 hypothetical protein; Provisional; Region: PRK10691 685038003567 hypothetical protein; Provisional; Region: PRK05170 685038003568 Haemolysin E (HlyE); Region: HlyE; cl11627 685038003569 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 685038003570 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 685038003571 Catalytic site [active] 685038003572 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 685038003573 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 685038003574 active site 685038003575 DNA binding site [nucleotide binding] 685038003576 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 685038003577 disulfide bond formation protein B; Provisional; Region: PRK01749 685038003578 sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547 685038003579 fatty acid metabolism regulator; Provisional; Region: PRK04984 685038003580 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 685038003581 DNA-binding site [nucleotide binding]; DNA binding site 685038003582 FadR C-terminal domain; Region: FadR_C; pfam07840 685038003583 SpoVR family protein; Provisional; Region: PRK11767 685038003584 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 685038003585 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 685038003586 alanine racemase; Reviewed; Region: dadX; PRK03646 685038003587 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 685038003588 active site 685038003589 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 685038003590 substrate binding site [chemical binding]; other site 685038003591 catalytic residues [active] 685038003592 dimer interface [polypeptide binding]; other site 685038003593 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 685038003594 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 685038003595 TrkA-C domain; Region: TrkA_C; pfam02080 685038003596 Transporter associated domain; Region: CorC_HlyC; smart01091 685038003597 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 685038003598 dimer interface [polypeptide binding]; other site 685038003599 catalytic triad [active] 685038003600 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 685038003601 N-acetyl-D-glucosamine binding site [chemical binding]; other site 685038003602 catalytic residue [active] 685038003603 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 685038003604 Flagellar regulator YcgR; Region: YcgR; pfam07317 685038003605 PilZ domain; Region: PilZ; pfam07238 685038003606 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 685038003607 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 685038003608 N-terminal plug; other site 685038003609 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 685038003610 ligand-binding site [chemical binding]; other site 685038003611 molybdenum transport protein ModD; Provisional; Region: PRK06096 685038003612 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 685038003613 dimerization interface [polypeptide binding]; other site 685038003614 active site 685038003615 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685038003616 S-adenosylmethionine binding site [chemical binding]; other site 685038003617 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 685038003618 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 685038003619 Walker A/P-loop; other site 685038003620 ATP binding site [chemical binding]; other site 685038003621 Q-loop/lid; other site 685038003622 ABC transporter signature motif; other site 685038003623 Walker B; other site 685038003624 D-loop; other site 685038003625 H-loop/switch region; other site 685038003626 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 685038003627 ABC-ATPase subunit interface; other site 685038003628 dimer interface [polypeptide binding]; other site 685038003629 putative PBP binding regions; other site 685038003630 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 685038003631 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 685038003632 putative metal binding site [ion binding]; other site 685038003633 trehalase; Provisional; Region: treA; PRK13271 685038003634 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 685038003635 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 685038003636 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3412 685038003637 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 685038003638 dimerization domain swap beta strand [polypeptide binding]; other site 685038003639 regulatory protein interface [polypeptide binding]; other site 685038003640 active site 685038003641 regulatory phosphorylation site [posttranslational modification]; other site 685038003642 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 685038003643 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 685038003644 dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005 685038003645 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 685038003646 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 685038003647 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 685038003648 putative active site [active] 685038003649 heme pocket [chemical binding]; other site 685038003650 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685038003651 Walker A motif; other site 685038003652 ATP binding site [chemical binding]; other site 685038003653 Walker B motif; other site 685038003654 arginine finger; other site 685038003655 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 685038003656 GTP-binding protein YchF; Reviewed; Region: PRK09601 685038003657 YchF GTPase; Region: YchF; cd01900 685038003658 G1 box; other site 685038003659 GTP/Mg2+ binding site [chemical binding]; other site 685038003660 Switch I region; other site 685038003661 G2 box; other site 685038003662 Switch II region; other site 685038003663 G3 box; other site 685038003664 G4 box; other site 685038003665 G5 box; other site 685038003666 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 685038003667 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 685038003668 putative active site [active] 685038003669 catalytic residue [active] 685038003670 hypothetical protein; Provisional; Region: PRK10692 685038003671 putative transporter; Provisional; Region: PRK11660 685038003672 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 685038003673 Sulfate transporter family; Region: Sulfate_transp; pfam00916 685038003674 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 685038003675 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 685038003676 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 685038003677 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 685038003678 active site 685038003679 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 685038003680 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 685038003681 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 685038003682 outer membrane lipoprotein LolB; Region: lolB; TIGR00548 685038003683 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 685038003684 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 685038003685 tRNA; other site 685038003686 putative tRNA binding site [nucleotide binding]; other site 685038003687 putative NADP binding site [chemical binding]; other site 685038003688 Glutamyl-tRNAGlu reductase, dimerization domain; Region: GlutR_dimer; pfam00745 685038003689 peptide chain release factor 1; Validated; Region: prfA; PRK00591 685038003690 This domain is found in peptide chain release factors; Region: PCRF; smart00937 685038003691 RF-1 domain; Region: RF-1; pfam00472 685038003692 HemK family putative methylases; Region: hemK_fam; TIGR00536 685038003693 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; cl17726 685038003694 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685038003695 S-adenosylmethionine binding site [chemical binding]; other site 685038003696 hypothetical protein; Provisional; Region: PRK10278 685038003697 hypothetical protein; Provisional; Region: PRK10941 685038003698 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 685038003699 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; COG2877 685038003700 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 685038003701 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 685038003702 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 685038003703 cation transport regulator; Reviewed; Region: chaB; PRK09582 685038003704 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 685038003705 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 685038003706 putative active site pocket [active] 685038003707 dimerization interface [polypeptide binding]; other site 685038003708 putative catalytic residue [active] 685038003709 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 685038003710 putative invasin; Provisional; Region: PRK10177 685038003711 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 685038003712 transcriptional regulator NarL; Provisional; Region: PRK10651 685038003713 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685038003714 active site 685038003715 phosphorylation site [posttranslational modification] 685038003716 intermolecular recognition site; other site 685038003717 dimerization interface [polypeptide binding]; other site 685038003718 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 685038003719 DNA binding residues [nucleotide binding] 685038003720 dimerization interface [polypeptide binding]; other site 685038003721 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 685038003722 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 685038003723 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 685038003724 dimerization interface [polypeptide binding]; other site 685038003725 Histidine kinase; Region: HisKA_3; pfam07730 685038003726 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685038003727 ATP binding site [chemical binding]; other site 685038003728 Mg2+ binding site [ion binding]; other site 685038003729 G-X-G motif; other site 685038003730 lysophospholipid transporter LplT; Provisional; Region: PRK11195; cl19150 685038003731 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 685038003732 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 685038003733 Respiratory nitrate reductase alpha N-terminal; Region: Nitr_red_alph_N; pfam14710 685038003734 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 685038003735 [4Fe-4S] binding site [ion binding]; other site 685038003736 molybdopterin cofactor binding site [chemical binding]; other site 685038003737 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 685038003738 molybdopterin cofactor binding site; other site 685038003739 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 685038003740 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 685038003741 Respiratory nitrate reductase beta C-terminal; Region: Nitr_red_bet_C; pfam14711 685038003742 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 685038003743 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 685038003744 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204 685038003745 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 685038003746 dimer interface [polypeptide binding]; other site 685038003747 active site 685038003748 CoA binding pocket [chemical binding]; other site 685038003749 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 685038003750 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685038003751 NAD(P) binding site [chemical binding]; other site 685038003752 active site 685038003753 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 685038003754 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 685038003755 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 685038003756 active site 685038003757 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 685038003758 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 685038003759 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 685038003760 putative di-iron ligands [ion binding]; other site 685038003761 potential protein location (hypothetical protein NRG857_06325 [Escherichia coli]) that overlaps RNA (tRNA-Y) 685038003762 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 685038003763 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 685038003764 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 685038003765 putative active site [active] 685038003766 putative substrate binding site [chemical binding]; other site 685038003767 putative cosubstrate binding site; other site 685038003768 catalytic site [active] 685038003769 SEC-C motif; Region: SEC-C; cl19389 685038003770 SEC-C motif; Region: SEC-C; cl19389 685038003771 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 685038003772 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 685038003773 active site 685038003774 nucleophile elbow; other site 685038003775 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685038003776 active site 685038003777 response regulator of RpoS; Provisional; Region: PRK10693 685038003778 phosphorylation site [posttranslational modification] 685038003779 intermolecular recognition site; other site 685038003780 dimerization interface [polypeptide binding]; other site 685038003781 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 685038003782 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 685038003783 active site 685038003784 tetramer interface; other site 685038003785 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 685038003786 DNA-binding protein H-NS [General function prediction only]; Region: Hns; COG2916 685038003787 thymidine kinase; Provisional; Region: PRK04296 685038003788 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 685038003789 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 685038003790 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 685038003791 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 685038003792 Coenzyme A acylating aldehyde dehydrogenase (ACDH), Ethanolamine utilization protein EutE, and related proteins; Region: ALDH_F20_ACDH_EutE-like; cd07081 685038003793 putative catalytic cysteine [active] 685038003794 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 685038003795 putative active site [active] 685038003796 metal binding site [ion binding]; metal-binding site 685038003797 hypothetical protein; Provisional; Region: PRK11111 685038003798 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 685038003799 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 685038003800 peptide binding site [polypeptide binding]; other site 685038003801 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 685038003802 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685038003803 dimer interface [polypeptide binding]; other site 685038003804 conserved gate region; other site 685038003805 putative PBP binding loops; other site 685038003806 ABC-ATPase subunit interface; other site 685038003807 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 685038003808 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 685038003809 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685038003810 dimer interface [polypeptide binding]; other site 685038003811 conserved gate region; other site 685038003812 putative PBP binding loops; other site 685038003813 ABC-ATPase subunit interface; other site 685038003814 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 685038003815 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 685038003816 Walker A/P-loop; other site 685038003817 ATP binding site [chemical binding]; other site 685038003818 Q-loop/lid; other site 685038003819 ABC transporter signature motif; other site 685038003820 Walker B; other site 685038003821 D-loop; other site 685038003822 H-loop/switch region; other site 685038003823 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 685038003824 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 685038003825 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 685038003826 Walker A/P-loop; other site 685038003827 ATP binding site [chemical binding]; other site 685038003828 Q-loop/lid; other site 685038003829 ABC transporter signature motif; other site 685038003830 Walker B; other site 685038003831 D-loop; other site 685038003832 H-loop/switch region; other site 685038003833 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 685038003834 dsDNA-mimic protein; Reviewed; Region: PRK05094 685038003835 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 685038003836 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 685038003837 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 685038003838 putative active site [active] 685038003839 catalytic site [active] 685038003840 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 685038003841 putative active site [active] 685038003842 catalytic site [active] 685038003843 voltage-gated potassium channel; Provisional; Region: PRK10537 685038003844 Ion channel; Region: Ion_trans_2; pfam07885 685038003845 TrkA-N domain; Region: TrkA_N; pfam02254 685038003846 YciI-like protein; Reviewed; Region: PRK11370 685038003847 transport protein TonB; Provisional; Region: PRK10819 685038003848 Gram-negative bacterial TonB protein C-terminal; Region: TonB_C; pfam03544 685038003849 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 685038003850 intracellular septation protein A; Reviewed; Region: PRK00259 685038003851 hypothetical protein; Provisional; Region: PRK02868 685038003852 outer membrane protein W; Provisional; Region: PRK10959 685038003853 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 685038003854 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 685038003855 dimerization interface [polypeptide binding]; other site 685038003856 metal binding site [ion binding]; metal-binding site 685038003857 General stress protein [General function prediction only]; Region: GsiB; COG3729 685038003858 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 685038003859 substrate binding site [chemical binding]; other site 685038003860 active site 685038003861 catalytic residues [active] 685038003862 heterodimer interface [polypeptide binding]; other site 685038003863 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 685038003864 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685038003865 catalytic residue [active] 685038003866 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 685038003867 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 685038003868 active site 685038003869 ribulose/triose binding site [chemical binding]; other site 685038003870 phosphate binding site [ion binding]; other site 685038003871 substrate (anthranilate) binding pocket [chemical binding]; other site 685038003872 product (indole) binding pocket [chemical binding]; other site 685038003873 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 685038003874 active site 685038003875 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 685038003876 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 685038003877 glutamine binding [chemical binding]; other site 685038003878 catalytic triad [active] 685038003879 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 685038003880 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 685038003881 anthranilate synthase component I; Provisional; Region: PRK13564 685038003882 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 685038003883 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 685038003884 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 685038003885 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 685038003886 active site 685038003887 hypothetical protein; Provisional; Region: PRK11630 685038003888 Predicted membrane protein (DUF2207); Region: DUF2207; cl19878 685038003889 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 685038003890 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 685038003891 RNA binding surface [nucleotide binding]; other site 685038003892 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 685038003893 probable active site [active] 685038003894 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 685038003895 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 685038003896 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 685038003897 homodimer interface [polypeptide binding]; other site 685038003898 Walker A motif; other site 685038003899 ATP binding site [chemical binding]; other site 685038003900 hydroxycobalamin binding site [chemical binding]; other site 685038003901 Walker B motif; other site 685038003902 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 685038003903 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 685038003904 NADP binding site [chemical binding]; other site 685038003905 homodimer interface [polypeptide binding]; other site 685038003906 active site 685038003907 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 685038003908 putative inner membrane peptidase; Provisional; Region: PRK11778 685038003909 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 685038003910 tandem repeat interface [polypeptide binding]; other site 685038003911 oligomer interface [polypeptide binding]; other site 685038003912 active site residues [active] 685038003913 hypothetical protein; Provisional; Region: PRK11037 685038003914 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 685038003915 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 685038003916 active site 685038003917 interdomain interaction site; other site 685038003918 putative metal-binding site [ion binding]; other site 685038003919 nucleotide binding site [chemical binding]; other site 685038003920 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 685038003921 domain I; other site 685038003922 DNA binding groove [nucleotide binding] 685038003923 phosphate binding site [ion binding]; other site 685038003924 domain II; other site 685038003925 domain III; other site 685038003926 nucleotide binding site [chemical binding]; other site 685038003927 catalytic site [active] 685038003928 domain IV; other site 685038003929 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 685038003930 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 685038003931 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 685038003932 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 685038003933 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 685038003934 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685038003935 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 685038003936 substrate binding site [chemical binding]; other site 685038003937 putative dimerization interface [polypeptide binding]; other site 685038003938 aconitate hydratase; Validated; Region: PRK09277 685038003939 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 685038003940 substrate binding site [chemical binding]; other site 685038003941 ligand binding site [chemical binding]; other site 685038003942 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 685038003943 substrate binding site [chemical binding]; other site 685038003944 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 685038003945 dimerization interface [polypeptide binding]; other site 685038003946 active site 685038003947 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 685038003948 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 685038003949 active site 685038003950 Predicted membrane protein [Function unknown]; Region: COG3771 685038003951 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 685038003952 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 685038003953 TPR motif; other site 685038003954 binding surface 685038003955 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 685038003956 binding surface 685038003957 TPR motif; other site 685038003958 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 685038003959 active site 685038003960 dimer interface [polypeptide binding]; other site 685038003961 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 685038003962 putative rRNA binding site [nucleotide binding]; other site 685038003963 lipoprotein; Provisional; Region: PRK10540 685038003964 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 685038003965 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 685038003966 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 685038003967 hypothetical protein; Provisional; Region: PRK13658 685038003968 RNase II stability modulator; Provisional; Region: PRK10060 685038003969 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 685038003970 putative active site [active] 685038003971 heme pocket [chemical binding]; other site 685038003972 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 685038003973 metal binding site [ion binding]; metal-binding site 685038003974 active site 685038003975 I-site; other site 685038003976 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 685038003977 exoribonuclease II; Provisional; Region: PRK05054 685038003978 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 685038003979 RNB domain; Region: RNB; pfam00773 685038003980 S1 RNA binding domain; Region: S1; pfam00575 685038003981 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 685038003982 Uncharacterized conserved protein [Function unknown]; Region: COG2128 685038003983 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 685038003984 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 685038003985 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 685038003986 NAD binding site [chemical binding]; other site 685038003987 homotetramer interface [polypeptide binding]; other site 685038003988 homodimer interface [polypeptide binding]; other site 685038003989 substrate binding site [chemical binding]; other site 685038003990 active site 685038003991 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685038003992 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685038003993 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 685038003994 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 685038003995 HlyD family secretion protein; Region: HlyD_3; pfam13437 685038003996 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 685038003997 MMPL family; Region: MMPL; cl14618 685038003998 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 685038003999 Outer membrane efflux protein; Region: OEP; pfam02321 685038004000 Outer membrane efflux protein; Region: OEP; pfam02321 685038004001 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 685038004002 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038004003 putative substrate translocation pore; other site 685038004004 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 685038004005 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 685038004006 Walker A/P-loop; other site 685038004007 ATP binding site [chemical binding]; other site 685038004008 Q-loop/lid; other site 685038004009 ABC transporter signature motif; other site 685038004010 Walker B; other site 685038004011 D-loop; other site 685038004012 H-loop/switch region; other site 685038004013 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 685038004014 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 685038004015 Walker A/P-loop; other site 685038004016 ATP binding site [chemical binding]; other site 685038004017 Q-loop/lid; other site 685038004018 ABC transporter signature motif; other site 685038004019 Walker B; other site 685038004020 D-loop; other site 685038004021 H-loop/switch region; other site 685038004022 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 685038004023 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 685038004024 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 685038004025 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685038004026 dimer interface [polypeptide binding]; other site 685038004027 conserved gate region; other site 685038004028 putative PBP binding loops; other site 685038004029 ABC-ATPase subunit interface; other site 685038004030 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapB; COG4168 685038004031 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685038004032 dimer interface [polypeptide binding]; other site 685038004033 conserved gate region; other site 685038004034 putative PBP binding loops; other site 685038004035 ABC-ATPase subunit interface; other site 685038004036 antimicrobial peptide ABC transporter periplasmic binding protein SapA; Provisional; Region: PRK15109 685038004037 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 685038004038 peptide binding site [polypeptide binding]; other site 685038004039 Protein of unknown function (DUF2543); Region: DUF2543; pfam10820 685038004040 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 685038004041 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 685038004042 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685038004043 Walker A motif; other site 685038004044 ATP binding site [chemical binding]; other site 685038004045 Walker B motif; other site 685038004046 arginine finger; other site 685038004047 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 685038004048 phage shock protein PspA; Provisional; Region: PRK10698 685038004049 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 685038004050 phage shock protein B; Provisional; Region: pspB; PRK09458 685038004051 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 685038004052 phage shock protein C; Region: phageshock_pspC; TIGR02978 685038004053 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 685038004054 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 685038004055 active site residue [active] 685038004056 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 685038004057 sucrose phosphorylase; Provisional; Region: PRK13840 685038004058 active site 685038004059 homodimer interface [polypeptide binding]; other site 685038004060 catalytic site [active] 685038004061 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 685038004062 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 685038004063 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 685038004064 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685038004065 dimer interface [polypeptide binding]; other site 685038004066 conserved gate region; other site 685038004067 putative PBP binding loops; other site 685038004068 ABC-ATPase subunit interface; other site 685038004069 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 685038004070 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685038004071 dimer interface [polypeptide binding]; other site 685038004072 conserved gate region; other site 685038004073 putative PBP binding loops; other site 685038004074 ABC-ATPase subunit interface; other site 685038004075 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 685038004076 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 685038004077 putative NAD(P) binding site [chemical binding]; other site 685038004078 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 685038004079 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 685038004080 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 685038004081 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 685038004082 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 685038004083 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 685038004084 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 685038004085 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 685038004086 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 685038004087 beta-phosphoglucomutase; Region: bPGM; TIGR01990 685038004088 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 685038004089 motif II; other site 685038004090 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 685038004091 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 685038004092 Walker A/P-loop; other site 685038004093 ATP binding site [chemical binding]; other site 685038004094 Q-loop/lid; other site 685038004095 ABC transporter signature motif; other site 685038004096 Walker B; other site 685038004097 D-loop; other site 685038004098 H-loop/switch region; other site 685038004099 TOBE domain; Region: TOBE_2; pfam08402 685038004100 Outer membrane protein G (OmpG); Region: Porin_OmpG; pfam09381 685038004101 Transcriptional regulators [Transcription]; Region: PurR; COG1609 685038004102 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 685038004103 DNA binding site [nucleotide binding] 685038004104 domain linker motif; other site 685038004105 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 685038004106 putative dimerization interface [polypeptide binding]; other site 685038004107 putative ligand binding site [chemical binding]; other site 685038004108 Predicted ATPase [General function prediction only]; Region: COG3106 685038004109 hypothetical protein; Provisional; Region: PRK05415 685038004110 Predicted membrane protein [Function unknown]; Region: COG3768 685038004111 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 685038004112 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 685038004113 putative aromatic amino acid binding site; other site 685038004114 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 685038004115 putative active site [active] 685038004116 heme pocket [chemical binding]; other site 685038004117 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685038004118 Walker A motif; other site 685038004119 ATP binding site [chemical binding]; other site 685038004120 Walker B motif; other site 685038004121 arginine finger; other site 685038004122 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 685038004123 dimer interface [polypeptide binding]; other site 685038004124 catalytic triad [active] 685038004125 peroxidatic and resolving cysteines [active] 685038004126 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 685038004127 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 685038004128 active site 685038004129 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 685038004130 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 685038004131 putative active site [active] 685038004132 Zn binding site [ion binding]; other site 685038004133 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685038004134 NAD(P) binding site [chemical binding]; other site 685038004135 active site 685038004136 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 685038004137 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 685038004138 Transcriptional regulator [Transcription]; Region: LysR; COG0583 685038004139 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685038004140 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 685038004141 putative effector binding pocket; other site 685038004142 putative dimerization interface [polypeptide binding]; other site 685038004143 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 685038004144 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 685038004145 peptide binding site [polypeptide binding]; other site 685038004146 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 685038004147 Mechanosensitive ion channel; Region: MS_channel; pfam00924 685038004148 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 685038004149 universal stress protein UspE; Provisional; Region: PRK11175 685038004150 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 685038004151 Ligand Binding Site [chemical binding]; other site 685038004152 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 685038004153 Ligand Binding Site [chemical binding]; other site 685038004154 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 685038004155 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 685038004156 ligand binding site [chemical binding]; other site 685038004157 flexible hinge region; other site 685038004158 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 685038004159 putative switch regulator; other site 685038004160 non-specific DNA interactions [nucleotide binding]; other site 685038004161 DNA binding site [nucleotide binding] 685038004162 sequence specific DNA binding site [nucleotide binding]; other site 685038004163 putative cAMP binding site [chemical binding]; other site 685038004164 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 685038004165 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 685038004166 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 685038004167 DNA binding site [nucleotide binding] 685038004168 active site 685038004169 AbgT putative transporter family; Region: ABG_transport; cl17431 685038004170 Helix-turn-helix domain; Region: HTH_18; pfam12833 685038004171 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 685038004172 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 685038004173 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 685038004174 Smr domain; Region: Smr; pfam01713 685038004175 PAS domain S-box; Region: sensory_box; TIGR00229 685038004176 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 685038004177 putative active site [active] 685038004178 heme pocket [chemical binding]; other site 685038004179 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 685038004180 metal binding site [ion binding]; metal-binding site 685038004181 active site 685038004182 I-site; other site 685038004183 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 685038004184 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 685038004185 Cl binding site [ion binding]; other site 685038004186 oligomer interface [polypeptide binding]; other site 685038004187 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 685038004188 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 685038004189 ATP binding site [chemical binding]; other site 685038004190 Mg++ binding site [ion binding]; other site 685038004191 motif III; other site 685038004192 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 685038004193 nucleotide binding region [chemical binding]; other site 685038004194 ATP-binding site [chemical binding]; other site 685038004195 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 685038004196 putative RNA binding site [nucleotide binding]; other site 685038004197 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 685038004198 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 685038004199 Ligand Binding Site [chemical binding]; other site 685038004200 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 685038004201 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 685038004202 Ligand Binding Site [chemical binding]; other site 685038004203 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 685038004204 trimer interface [polypeptide binding]; other site 685038004205 eyelet of channel; other site 685038004206 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 685038004207 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 685038004208 dimer interface [polypeptide binding]; other site 685038004209 PYR/PP interface [polypeptide binding]; other site 685038004210 TPP binding site [chemical binding]; other site 685038004211 substrate binding site [chemical binding]; other site 685038004212 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 685038004213 Domain of unknown function; Region: EKR; pfam10371 685038004214 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 685038004215 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 685038004216 TPP-binding site [chemical binding]; other site 685038004217 dimer interface [polypeptide binding]; other site 685038004218 metabolite-proton symporter; Region: 2A0106; TIGR00883 685038004219 heat-inducible protein; Provisional; Region: PRK10449 685038004220 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 685038004221 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 685038004222 putative ligand binding site [chemical binding]; other site 685038004223 putative NAD binding site [chemical binding]; other site 685038004224 catalytic site [active] 685038004225 hypothetical protein; Provisional; Region: PRK10695 685038004226 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 685038004227 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 685038004228 Autotransporter beta-domain; Region: Autotransporter; pfam03797 685038004229 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 685038004230 active site 685038004231 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 685038004232 catalytic tetrad [active] 685038004233 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 685038004234 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 685038004235 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 685038004236 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 685038004237 Putative methyltransferase; Region: Methyltransf_20; pfam12147 685038004238 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685038004239 S-adenosylmethionine binding site [chemical binding]; other site 685038004240 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 685038004241 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 685038004242 active site 685038004243 Dual specificity phosphatase, catalytic domain; Region: DSPc; smart00195 685038004244 Predicted protein-tyrosine phosphatase [Signal transduction mechanisms]; Region: CDC14; COG2453 685038004245 active site 685038004246 catalytic residues [active] 685038004247 azoreductase; Reviewed; Region: PRK00170 685038004248 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 685038004249 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 685038004250 ATP binding site [chemical binding]; other site 685038004251 putative Mg++ binding site [ion binding]; other site 685038004252 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 685038004253 nucleotide binding region [chemical binding]; other site 685038004254 ATP-binding site [chemical binding]; other site 685038004255 Helicase associated domain (HA2); Region: HA2; pfam04408 685038004256 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 685038004257 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 685038004258 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 685038004259 putative active site [active] 685038004260 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 685038004261 NAD binding site [chemical binding]; other site 685038004262 catalytic residues [active] 685038004263 substrate binding site [chemical binding]; other site 685038004264 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 685038004265 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 685038004266 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 685038004267 cytochrome b561; Provisional; Region: PRK11513 685038004268 hypothetical protein; Provisional; Region: PRK10040 685038004269 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 685038004270 dimer interface [polypeptide binding]; other site 685038004271 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 685038004272 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685038004273 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 685038004274 dimerization interface [polypeptide binding]; other site 685038004275 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 685038004276 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 685038004277 hypothetical protein; Provisional; Region: PRK11415 685038004278 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 685038004279 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 685038004280 Coenzyme A binding pocket [chemical binding]; other site 685038004281 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 685038004282 putative trimer interface [polypeptide binding]; other site 685038004283 putative CoA binding site [chemical binding]; other site 685038004284 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 685038004285 putative trimer interface [polypeptide binding]; other site 685038004286 putative CoA binding site [chemical binding]; other site 685038004287 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 685038004288 gating phenylalanine in ion channel; other site 685038004289 tellurite resistance protein TehB; Provisional; Region: PRK11207 685038004290 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685038004291 S-adenosylmethionine binding site [chemical binding]; other site 685038004292 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 685038004293 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 685038004294 benzoate transporter; Region: benE; TIGR00843 685038004295 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 685038004296 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 685038004297 non-specific DNA binding site [nucleotide binding]; other site 685038004298 salt bridge; other site 685038004299 sequence-specific DNA binding site [nucleotide binding]; other site 685038004300 Cupin domain; Region: Cupin_2; pfam07883 685038004301 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 685038004302 putative protease; Provisional; Region: PRK15452 685038004303 Collagenase; Region: DUF3656; pfam12392 685038004304 Protein of unknown function (DUF2554); Region: DUF2554; pfam10829 685038004305 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 685038004306 sequence-specific DNA binding site [nucleotide binding]; other site 685038004307 salt bridge; other site 685038004308 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 685038004309 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 685038004310 DNA-binding site [nucleotide binding]; DNA binding site 685038004311 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 685038004312 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685038004313 homodimer interface [polypeptide binding]; other site 685038004314 catalytic residue [active] 685038004315 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 685038004316 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 685038004317 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685038004318 Walker A/P-loop; other site 685038004319 ATP binding site [chemical binding]; other site 685038004320 Q-loop/lid; other site 685038004321 ABC transporter signature motif; other site 685038004322 Walker B; other site 685038004323 D-loop; other site 685038004324 H-loop/switch region; other site 685038004325 TOBE domain; Region: TOBE_2; pfam08402 685038004326 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685038004327 dimer interface [polypeptide binding]; other site 685038004328 conserved gate region; other site 685038004329 putative PBP binding loops; other site 685038004330 ABC-ATPase subunit interface; other site 685038004331 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 685038004332 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685038004333 dimer interface [polypeptide binding]; other site 685038004334 conserved gate region; other site 685038004335 putative PBP binding loops; other site 685038004336 ABC-ATPase subunit interface; other site 685038004337 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 685038004338 tetrameric interface [polypeptide binding]; other site 685038004339 NAD binding site [chemical binding]; other site 685038004340 catalytic residues [active] 685038004341 substrate binding site [chemical binding]; other site 685038004342 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 685038004343 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 685038004344 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 685038004345 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 685038004346 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 685038004347 Coenzyme A binding pocket [chemical binding]; other site 685038004348 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 685038004349 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 685038004350 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 685038004351 N-terminal plug; other site 685038004352 ligand-binding site [chemical binding]; other site 685038004353 PQQ-like domain; Region: PQQ_2; pfam13360 685038004354 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 685038004355 L-asparagine permease; Provisional; Region: PRK15049 685038004356 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 685038004357 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 685038004358 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 685038004359 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 685038004360 N-terminal domain interface [polypeptide binding]; other site 685038004361 dimer interface [polypeptide binding]; other site 685038004362 substrate binding pocket (H-site) [chemical binding]; other site 685038004363 PAAR motif; Region: PAAR_motif; pfam05488 685038004364 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 685038004365 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 685038004366 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 685038004367 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 685038004368 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 685038004369 Domain of unknown function (DUF4279); Region: DUF4279; pfam14106 685038004370 potential frameshift: common BLAST hit: gi|110642861|ref|YP_670591.1| transposase 685038004371 potential frameshift: common BLAST hit: gi|218552823|ref|YP_002385736.1| putative transposase 685038004372 PAAR motif; Region: PAAR_motif; pfam05488 685038004373 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 685038004374 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 685038004375 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 685038004376 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 685038004377 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 685038004378 Peptidase M35-like domain of uncharacterized proteins; Region: M35_like_1; cd11007 685038004379 putative active site [active] 685038004380 putative Zn binding site [ion binding]; other site 685038004381 Transposase [DNA replication, recombination, and repair]; Region: COG5433 685038004382 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 685038004383 N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047 685038004384 hypothetical protein; Provisional; Region: PRK10281 685038004385 phenazine biosynthesis protein PhzF family; Region: PhzF_family; TIGR00654 685038004386 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 685038004387 nitrate reductase 2 subunit delta; Provisional; Region: PRK15054 685038004388 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 685038004389 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 685038004390 Respiratory nitrate reductase beta C-terminal; Region: Nitr_red_bet_C; pfam14711 685038004391 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 685038004392 Respiratory nitrate reductase alpha N-terminal; Region: Nitr_red_alph_N; pfam14710 685038004393 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 685038004394 [4Fe-4S] binding site [ion binding]; other site 685038004395 molybdopterin cofactor binding site [chemical binding]; other site 685038004396 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 685038004397 molybdopterin cofactor binding site; other site 685038004398 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 685038004399 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 685038004400 aromatic amino acid exporter; Provisional; Region: PRK11689 685038004401 EamA-like transporter family; Region: EamA; pfam00892 685038004402 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 685038004403 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 685038004404 molybdopterin cofactor binding site; other site 685038004405 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 685038004406 molybdopterin cofactor binding site; other site 685038004407 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 685038004408 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 685038004409 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 685038004410 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 685038004411 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 685038004412 non-specific DNA binding site [nucleotide binding]; other site 685038004413 salt bridge; other site 685038004414 sequence-specific DNA binding site [nucleotide binding]; other site 685038004415 Plasmid maintenance system killer protein; Region: Plasmid_killer; pfam05015 685038004416 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 685038004417 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 685038004418 NAD binding site [chemical binding]; other site 685038004419 substrate binding site [chemical binding]; other site 685038004420 catalytic Zn binding site [ion binding]; other site 685038004421 tetramer interface [polypeptide binding]; other site 685038004422 structural Zn binding site [ion binding]; other site 685038004423 malate dehydrogenase; Provisional; Region: PRK13529 685038004424 Malic enzyme, N-terminal domain; Region: malic; pfam00390 685038004425 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 685038004426 NAD(P) binding site [chemical binding]; other site 685038004427 30S ribosomal subunit S22; Reviewed; Region: rpsV; PRK10057 685038004428 Putative biofilm-dependent modulation protein; Region: BDM; cl11581 685038004429 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 685038004430 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 685038004431 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 685038004432 putative active site [active] 685038004433 heme pocket [chemical binding]; other site 685038004434 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 685038004435 putative active site [active] 685038004436 heme pocket [chemical binding]; other site 685038004437 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 685038004438 metal binding site [ion binding]; metal-binding site 685038004439 active site 685038004440 I-site; other site 685038004441 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 685038004442 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 685038004443 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 685038004444 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 685038004445 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 685038004446 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685038004447 catalytic residue [active] 685038004448 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 685038004449 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 685038004450 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 685038004451 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 685038004452 FeS/SAM binding site; other site 685038004453 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 685038004454 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 685038004455 Sulfatase; Region: Sulfatase; pfam00884 685038004456 transcriptional regulator YdeO; Provisional; Region: PRK09940 685038004457 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 685038004458 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 685038004459 putative oxidoreductase; Provisional; Region: PRK09939 685038004460 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 685038004461 putative molybdopterin cofactor binding site [chemical binding]; other site 685038004462 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 685038004463 putative molybdopterin cofactor binding site; other site 685038004464 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 685038004465 mannosyl binding site [chemical binding]; other site 685038004466 Fimbrial protein; Region: Fimbrial; cl01416 685038004467 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 685038004468 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 685038004469 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 685038004470 PapC N-terminal domain; Region: PapC_N; pfam13954 685038004471 Outer membrane usher protein; Region: Usher; pfam00577 685038004472 PapC C-terminal domain; Region: PapC_C; pfam13953 685038004473 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 685038004474 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 685038004475 core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107 685038004476 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 685038004477 Fimbrial protein; Region: Fimbrial; cl01416 685038004478 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 685038004479 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 685038004480 NAD(P) binding site [chemical binding]; other site 685038004481 putative active site [active] 685038004482 Transcriptional regulator [Transcription]; Region: LysR; COG0583 685038004483 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685038004484 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 685038004485 dimerization interface [polypeptide binding]; other site 685038004486 Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-3; cd12810 685038004487 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 685038004488 catalytic site [active] 685038004489 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 685038004490 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 685038004491 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 685038004492 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685038004493 intermolecular recognition site; other site 685038004494 active site 685038004495 dimerization interface [polypeptide binding]; other site 685038004496 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 685038004497 DNA binding site [nucleotide binding] 685038004498 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 685038004499 HipA N-terminal domain; Region: couple_hipA; TIGR03071 685038004500 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 685038004501 HipA-like N-terminal domain; Region: HipA_N; pfam07805 685038004502 HipA-like C-terminal domain; Region: HipA_C; pfam07804 685038004503 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 685038004504 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 685038004505 non-specific DNA binding site [nucleotide binding]; other site 685038004506 salt bridge; other site 685038004507 sequence-specific DNA binding site [nucleotide binding]; other site 685038004508 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 685038004509 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685038004510 S-adenosylmethionine binding site [chemical binding]; other site 685038004511 Predicted membrane protein [Function unknown]; Region: COG3781 685038004512 altronate oxidoreductase; Provisional; Region: PRK03643 685038004513 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 685038004514 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 685038004515 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 685038004516 metal binding site [ion binding]; metal-binding site 685038004517 active site 685038004518 I-site; other site 685038004519 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 685038004520 glutaminase; Provisional; Region: PRK00971 685038004521 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 685038004522 NAD(P) binding site [chemical binding]; other site 685038004523 catalytic residues [active] 685038004524 Transcriptional regulator [Transcription]; Region: LysR; COG0583 685038004525 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685038004526 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 685038004527 putative dimerization interface [polypeptide binding]; other site 685038004528 putative arabinose transporter; Provisional; Region: PRK03545 685038004529 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038004530 putative substrate translocation pore; other site 685038004531 inner membrane protein; Provisional; Region: PRK10995 685038004532 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 685038004533 Transcriptional regulators [Transcription]; Region: MarR; COG1846 685038004534 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 685038004535 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 685038004536 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 685038004537 MarB protein; Region: MarB; pfam13999 685038004538 6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589 685038004539 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 685038004540 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 685038004541 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 685038004542 trimer interface; other site 685038004543 maltoporin; Provisional; Region: lamB; PRK09360 685038004544 sugar binding site [chemical binding]; other site 685038004545 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 685038004546 active site 685038004547 methionine cluster; other site 685038004548 phosphorylation site [posttranslational modification] 685038004549 metal binding site [ion binding]; metal-binding site 685038004550 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 685038004551 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 685038004552 active site 685038004553 P-loop; other site 685038004554 phosphorylation site [posttranslational modification] 685038004555 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 685038004556 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 685038004557 DNA-binding site [nucleotide binding]; DNA binding site 685038004558 UTRA domain; Region: UTRA; pfam07702 685038004559 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 685038004560 EamA-like transporter family; Region: EamA; pfam00892 685038004561 EamA-like transporter family; Region: EamA; pfam00892 685038004562 putative transporter; Provisional; Region: PRK10054 685038004563 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038004564 putative substrate translocation pore; other site 685038004565 diguanylate cyclase; Provisional; Region: PRK09894 685038004566 Chemoreceptor zinc-binding domain; Region: CZB; pfam13682 685038004567 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 685038004568 metal binding site [ion binding]; metal-binding site 685038004569 active site 685038004570 I-site; other site 685038004571 Bacterial OB fold (BOF) protein; Region: BOF; cl01196 685038004572 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 685038004573 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 685038004574 active site 685038004575 Zn binding site [ion binding]; other site 685038004576 malonic semialdehyde reductase; Provisional; Region: PRK10538 685038004577 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 685038004578 putative NAD(P) binding site [chemical binding]; other site 685038004579 homodimer interface [polypeptide binding]; other site 685038004580 homotetramer interface [polypeptide binding]; other site 685038004581 active site 685038004582 Transcriptional regulators [Transcription]; Region: GntR; COG1802 685038004583 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 685038004584 DNA-binding site [nucleotide binding]; DNA binding site 685038004585 FCD domain; Region: FCD; pfam07729 685038004586 putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318 685038004587 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 685038004588 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 685038004589 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 685038004590 metabolite-proton symporter; Region: 2A0106; TIGR00883 685038004591 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038004592 putative substrate translocation pore; other site 685038004593 multiple promoter invertase; Provisional; Region: mpi; PRK13413 685038004594 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 685038004595 catalytic residues [active] 685038004596 catalytic nucleophile [active] 685038004597 Presynaptic Site I dimer interface [polypeptide binding]; other site 685038004598 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 685038004599 Synaptic Flat tetramer interface [polypeptide binding]; other site 685038004600 Synaptic Site I dimer interface [polypeptide binding]; other site 685038004601 DNA binding site [nucleotide binding] 685038004602 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cd00569 685038004603 DNA-binding interface [nucleotide binding]; DNA binding site 685038004604 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 685038004605 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 685038004606 Phage-related protein, tail component [Function unknown]; Region: COG4733 685038004607 Putative phage tail protein; Region: Phage-tail_3; pfam13550 685038004608 Fibronectin type 3 domain; Region: FN3; smart00060 685038004609 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 685038004610 Fibronectin type III protein; Region: DUF3672; pfam12421 685038004611 Phage-related protein, tail component [Function unknown]; Region: COG4723 685038004612 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 685038004613 MPN+ (JAMM) motif; other site 685038004614 Zinc-binding site [ion binding]; other site 685038004615 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 685038004616 NlpC/P60 family; Region: NLPC_P60; cl17555 685038004617 Phage-related protein [Function unknown]; Region: gp18; COG4672 685038004618 Phage-related protein [Function unknown]; Region: COG4718 685038004619 Phage-related minor tail protein [Function unknown]; Region: COG5281 685038004620 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 685038004621 BAF1 / ABF1 chromatin reorganizing factor; Region: BAF1_ABF1; pfam04684 685038004622 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; cl19901 685038004623 Minor tail protein T; Region: Phage_tail_T; pfam06223 685038004624 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; cl06106 685038004625 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 685038004626 Phage tail protein; Region: Phage_tail_3; pfam08813 685038004627 Bacterial Ig-like domain 2; Region: BID_2; smart00635 685038004628 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 685038004629 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 685038004630 ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; pfam13856 685038004631 Uncharacterized conserved protein [Function unknown]; Region: COG5471 685038004632 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 685038004633 oligomer interface [polypeptide binding]; other site 685038004634 active site residues [active] 685038004635 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 685038004636 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 685038004637 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 685038004638 Protein of unknown function (DUF1441); Region: DUF1441; pfam07278 685038004639 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 685038004640 GnsA/GnsB family; Region: GnsAB; pfam08178 685038004641 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 685038004642 DNA-binding site [nucleotide binding]; DNA binding site 685038004643 RNA-binding motif; other site 685038004644 Protein of unknown function (DUF2514); Region: DUF2514; pfam10721 685038004645 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 685038004646 catalytic residues [active] 685038004647 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 685038004648 Lysis protein S; Region: Lysis_S; pfam04971 685038004649 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 685038004650 DNA-binding site [nucleotide binding]; DNA binding site 685038004651 RNA-binding motif; other site 685038004652 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 685038004653 DNA-binding site [nucleotide binding]; DNA binding site 685038004654 RNA-binding motif; other site 685038004655 Antitermination protein; Region: Antiterm; pfam03589 685038004656 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cl19048 685038004657 Antitermination protein; Region: Antiterm; pfam03589 685038004658 Protein of unknown function (DUF968); Region: DUF968; pfam06147 685038004659 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 685038004660 active site 685038004661 Hok/gef family; Region: HOK_GEF; pfam01848 685038004662 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 685038004663 primosomal protein DnaI; Provisional; Region: PRK02854 685038004664 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 685038004665 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 685038004666 transcriptional repressor DicA; Reviewed; Region: PRK09706 685038004667 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 685038004668 non-specific DNA binding site [nucleotide binding]; other site 685038004669 salt bridge; other site 685038004670 sequence-specific DNA binding site [nucleotide binding]; other site 685038004671 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 685038004672 DicB protein; Region: DicB; pfam05358 685038004673 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 685038004674 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 685038004675 active site 685038004676 catalytic site [active] 685038004677 substrate binding site [chemical binding]; other site 685038004678 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 685038004679 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 685038004680 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 685038004681 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 685038004682 Int/Topo IB signature motif; other site 685038004683 putative oxidoreductase; Provisional; Region: PRK10083 685038004684 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 685038004685 putative NAD(P) binding site [chemical binding]; other site 685038004686 catalytic Zn binding site [ion binding]; other site 685038004687 structural Zn binding site [ion binding]; other site 685038004688 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 685038004689 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 685038004690 putative active site pocket [active] 685038004691 putative metal binding site [ion binding]; other site 685038004692 hypothetical protein; Provisional; Region: PRK02237 685038004693 hypothetical protein; Provisional; Region: PRK13659 685038004694 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 685038004695 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 685038004696 Coenzyme A binding pocket [chemical binding]; other site 685038004697 Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788 685038004698 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 685038004699 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 685038004700 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 685038004701 putative [Fe4-S4] binding site [ion binding]; other site 685038004702 putative molybdopterin cofactor binding site [chemical binding]; other site 685038004703 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 685038004704 putative molybdopterin cofactor binding site; other site 685038004705 potential frameshift: common BLAST hit: gi|209918900|ref|YP_002292984.1| putative dimethyl sulfoxide reductase major subunit 685038004706 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 685038004707 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 685038004708 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 685038004709 putative molybdopterin cofactor binding site; other site 685038004710 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 685038004711 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 685038004712 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 685038004713 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 685038004714 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 685038004715 Cl- selectivity filter; other site 685038004716 Cl- binding residues [ion binding]; other site 685038004717 pore gating glutamate residue; other site 685038004718 dimer interface [polypeptide binding]; other site 685038004719 putative dithiobiotin synthetase; Provisional; Region: PRK12374 685038004720 AAA domain; Region: AAA_26; pfam13500 685038004721 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 685038004722 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 685038004723 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 685038004724 nucleotide binding site [chemical binding]; other site 685038004725 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 685038004726 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 685038004727 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685038004728 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 685038004729 dimerization interface [polypeptide binding]; other site 685038004730 substrate binding pocket [chemical binding]; other site 685038004731 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 685038004732 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038004733 putative substrate translocation pore; other site 685038004734 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 685038004735 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 685038004736 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 685038004737 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 685038004738 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 685038004739 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 685038004740 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 685038004741 ligand binding site [chemical binding]; other site 685038004742 homodimer interface [polypeptide binding]; other site 685038004743 NAD(P) binding site [chemical binding]; other site 685038004744 trimer interface B [polypeptide binding]; other site 685038004745 trimer interface A [polypeptide binding]; other site 685038004746 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 685038004747 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 685038004748 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 685038004749 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 685038004750 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 685038004751 Spore germination protein; Region: Spore_permease; cl17796 685038004752 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 685038004753 pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357 685038004754 NADP binding site [chemical binding]; other site 685038004755 substrate binding pocket [chemical binding]; other site 685038004756 active site 685038004757 GlpM protein; Region: GlpM; pfam06942 685038004758 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 685038004759 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685038004760 active site 685038004761 phosphorylation site [posttranslational modification] 685038004762 intermolecular recognition site; other site 685038004763 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 685038004764 DNA binding site [nucleotide binding] 685038004765 sensor protein RstB; Provisional; Region: PRK10604 685038004766 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 685038004767 dimerization interface [polypeptide binding]; other site 685038004768 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 685038004769 dimer interface [polypeptide binding]; other site 685038004770 phosphorylation site [posttranslational modification] 685038004771 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685038004772 ATP binding site [chemical binding]; other site 685038004773 Mg2+ binding site [ion binding]; other site 685038004774 G-X-G motif; other site 685038004775 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 685038004776 fumarate hydratase; Reviewed; Region: fumC; PRK00485 685038004777 Class II fumarases; Region: Fumarase_classII; cd01362 685038004778 active site 685038004779 tetramer interface [polypeptide binding]; other site 685038004780 fumarate hydratase; Provisional; Region: PRK15389 685038004781 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 685038004782 Fumarase C-terminus; Region: Fumerase_C; pfam05683 685038004783 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 685038004784 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 685038004785 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 685038004786 putative outer membrane porin protein; Provisional; Region: PRK11379 685038004787 glucuronide transporter; Provisional; Region: PRK09848 685038004788 putative symporter YagG; Provisional; Region: PRK09669; cl15392 685038004789 beta-D-glucuronidase; Provisional; Region: PRK10150 685038004790 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 685038004791 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 685038004792 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 685038004793 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685038004794 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685038004795 7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113 685038004796 7 alpha-hydroxysteroid dehydrogenase (7 alpha-HSDH), classical (c) SDRs; Region: 7_alpha_HSDH_SDR_c; cd05365 685038004797 NAD binding site [chemical binding]; other site 685038004798 substrate binding site [chemical binding]; other site 685038004799 homotetramer interface [polypeptide binding]; other site 685038004800 homodimer interface [polypeptide binding]; other site 685038004801 active site 685038004802 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 685038004803 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 685038004804 DNA binding site [nucleotide binding] 685038004805 domain linker motif; other site 685038004806 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 685038004807 putative dimerization interface [polypeptide binding]; other site 685038004808 putative ligand binding site [chemical binding]; other site 685038004809 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 685038004810 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 685038004811 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 685038004812 active site turn [active] 685038004813 phosphorylation site [posttranslational modification] 685038004814 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 685038004815 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 685038004816 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685038004817 homodimer interface [polypeptide binding]; other site 685038004818 catalytic residue [active] 685038004819 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 685038004820 active site 685038004821 purine riboside binding site [chemical binding]; other site 685038004822 putative oxidoreductase; Provisional; Region: PRK11579 685038004823 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 685038004824 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 685038004825 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 685038004826 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 685038004827 electron transport complex protein RsxA; Provisional; Region: PRK05151 685038004828 electron transport complex protein RnfB; Provisional; Region: PRK05113 685038004829 Putative Fe-S cluster; Region: FeS; pfam04060 685038004830 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 685038004831 electron transport complex protein RnfC; Provisional; Region: PRK05035 685038004832 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 685038004833 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 685038004834 SLBB domain; Region: SLBB; pfam10531 685038004835 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 685038004836 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 685038004837 electron transport complex protein RnfG; Validated; Region: PRK01908 685038004838 electron transport complex RsxE subunit; Provisional; Region: PRK12405 685038004839 endonuclease III; Provisional; Region: PRK10702 685038004840 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 685038004841 minor groove reading motif; other site 685038004842 helix-hairpin-helix signature motif; other site 685038004843 substrate binding pocket [chemical binding]; other site 685038004844 active site 685038004845 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 685038004846 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 685038004847 putative tripeptide transporter permease; Reviewed; Region: tppB; PRK09584 685038004848 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038004849 putative substrate translocation pore; other site 685038004850 glutathionine S-transferase; Provisional; Region: PRK10542 685038004851 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 685038004852 C-terminal domain interface [polypeptide binding]; other site 685038004853 GSH binding site (G-site) [chemical binding]; other site 685038004854 dimer interface [polypeptide binding]; other site 685038004855 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 685038004856 N-terminal domain interface [polypeptide binding]; other site 685038004857 dimer interface [polypeptide binding]; other site 685038004858 substrate binding pocket (H-site) [chemical binding]; other site 685038004859 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 685038004860 dimer interface [polypeptide binding]; other site 685038004861 pyridoxal binding site [chemical binding]; other site 685038004862 ATP binding site [chemical binding]; other site 685038004863 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 685038004864 Protein of unknown function (DUF2859); Region: DUF2859; cl12633 685038004865 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 685038004866 active site 685038004867 HIGH motif; other site 685038004868 dimer interface [polypeptide binding]; other site 685038004869 KMSKS motif; other site 685038004870 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 685038004871 RNA binding surface [nucleotide binding]; other site 685038004872 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 685038004873 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 685038004874 Pyridoxine 5'-phosphate oxidase C-terminal dimerization region; Region: PNPOx_C; pfam10590 685038004875 lysozyme inhibitor; Provisional; Region: PRK11372 685038004876 Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702 685038004877 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 685038004878 transcriptional regulator SlyA; Provisional; Region: PRK03573 685038004879 Transcriptional regulators [Transcription]; Region: MarR; COG1846 685038004880 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 685038004881 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 685038004882 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 685038004883 HlyD family secretion protein; Region: HlyD_3; pfam13437 685038004884 Fusaric acid resistance protein family; Region: FUSC; pfam04632 685038004885 Fusaric acid resistance protein-like; Region: FUSC_2; cl19401 685038004886 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 685038004887 E-class dimer interface [polypeptide binding]; other site 685038004888 P-class dimer interface [polypeptide binding]; other site 685038004889 active site 685038004890 Cu2+ binding site [ion binding]; other site 685038004891 Zn2+ binding site [ion binding]; other site 685038004892 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 685038004893 active site 685038004894 catalytic tetrad [active] 685038004895 Predicted Fe-S protein [General function prediction only]; Region: COG3313 685038004896 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685038004897 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685038004898 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 685038004899 FMN binding site [chemical binding]; other site 685038004900 active site 685038004901 substrate binding site [chemical binding]; other site 685038004902 catalytic residue [active] 685038004903 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 685038004904 dimer interface [polypeptide binding]; other site 685038004905 active site 685038004906 metal binding site [ion binding]; metal-binding site 685038004907 glutathione binding site [chemical binding]; other site 685038004908 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 685038004909 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 685038004910 dimer interface [polypeptide binding]; other site 685038004911 catalytic site [active] 685038004912 putative active site [active] 685038004913 putative substrate binding site [chemical binding]; other site 685038004914 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 685038004915 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 685038004916 putative GSH binding site [chemical binding]; other site 685038004917 catalytic residues [active] 685038004918 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 685038004919 NlpC/P60 family; Region: NLPC_P60; pfam00877 685038004920 superoxide dismutase; Provisional; Region: PRK10543 685038004921 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 685038004922 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 685038004923 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 685038004924 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038004925 putative substrate translocation pore; other site 685038004926 hypothetical protein; Provisional; Region: PRK14756 685038004927 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 685038004928 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 685038004929 DNA binding site [nucleotide binding] 685038004930 domain linker motif; other site 685038004931 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 685038004932 dimerization interface [polypeptide binding]; other site 685038004933 ligand binding site [chemical binding]; other site 685038004934 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 685038004935 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685038004936 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 685038004937 dimerization interface [polypeptide binding]; other site 685038004938 putative transporter; Provisional; Region: PRK11043 685038004939 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038004940 putative substrate translocation pore; other site 685038004941 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 685038004942 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 685038004943 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685038004944 S-adenosylmethionine binding site [chemical binding]; other site 685038004945 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 685038004946 Lumazine binding domain; Region: Lum_binding; pfam00677 685038004947 Lumazine binding domain; Region: Lum_binding; pfam00677 685038004948 multidrug efflux protein; Reviewed; Region: PRK01766 685038004949 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 685038004950 cation binding site [ion binding]; other site 685038004951 hypothetical protein; Provisional; Region: PRK09945 685038004952 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 685038004953 putative monooxygenase; Provisional; Region: PRK11118 685038004954 hypothetical protein; Provisional; Region: PRK09897 685038004955 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 685038004956 hypothetical protein; Provisional; Region: PRK09946 685038004957 thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006 685038004958 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 685038004959 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 685038004960 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 685038004961 hypothetical protein; Provisional; Region: PRK09947 685038004962 putative oxidoreductase; Provisional; Region: PRK09849 685038004963 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 685038004964 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 685038004965 hypothetical protein; Provisional; Region: PRK09898 685038004966 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 685038004967 hypothetical protein; Provisional; Region: PRK10292 685038004968 pyruvate kinase; Provisional; Region: PRK09206 685038004969 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 685038004970 domain interfaces; other site 685038004971 active site 685038004972 murein lipoprotein; Provisional; Region: PRK15396 685038004973 L,D-transpeptidase; Provisional; Region: PRK10260 685038004974 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 685038004975 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 685038004976 cysteine desufuration protein SufE; Provisional; Region: PRK09296 685038004977 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 685038004978 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 685038004979 catalytic residue [active] 685038004980 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 685038004981 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 685038004982 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 685038004983 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 685038004984 Walker A/P-loop; other site 685038004985 ATP binding site [chemical binding]; other site 685038004986 Q-loop/lid; other site 685038004987 ABC transporter signature motif; other site 685038004988 Walker B; other site 685038004989 D-loop; other site 685038004990 H-loop/switch region; other site 685038004991 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 685038004992 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 685038004993 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 685038004994 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 685038004995 CoenzymeA binding site [chemical binding]; other site 685038004996 subunit interaction site [polypeptide binding]; other site 685038004997 PHB binding site; other site 685038004998 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 685038004999 FAD binding domain; Region: FAD_binding_4; pfam01565 685038005000 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 685038005001 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 685038005002 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 685038005003 putative inner membrane protein; Provisional; Region: PRK10983 685038005004 Domain of unknown function (DUF1870); Region: DUF1870; pfam08965 685038005005 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038005006 Major Facilitator Superfamily; Region: MFS_1; pfam07690 685038005007 putative substrate translocation pore; other site 685038005008 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038005009 Major Facilitator Superfamily; Region: MFS_1; pfam07690 685038005010 putative substrate translocation pore; other site 685038005011 quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749 685038005012 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 685038005013 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 685038005014 shikimate binding site; other site 685038005015 NAD(P) binding site [chemical binding]; other site 685038005016 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 685038005017 active site 685038005018 catalytic residue [active] 685038005019 dimer interface [polypeptide binding]; other site 685038005020 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 685038005021 Coenzyme A transferase; Region: CoA_trans; smart00882 685038005022 Coenzyme A transferase; Region: CoA_trans; cl17247 685038005023 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 685038005024 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 685038005025 active site 685038005026 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 685038005027 Cupin domain; Region: Cupin_2; pfam07883 685038005028 Winged helix DNA-binding domain (DUF1495); Region: DUF1495; cl01336 685038005029 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 685038005030 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 685038005031 Ligand binding site [chemical binding]; other site 685038005032 electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916 685038005033 Electron transfer flavoprotein domain; Region: ETF; pfam01012 685038005034 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 685038005035 oxidoreductase; Provisional; Region: PRK10015 685038005036 putative oxidoreductase FixC; Provisional; Region: PRK10157 685038005037 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 685038005038 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 685038005039 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 685038005040 acyl-activating enzyme (AAE) consensus motif; other site 685038005041 putative AMP binding site [chemical binding]; other site 685038005042 putative active site [active] 685038005043 putative CoA binding site [chemical binding]; other site 685038005044 phosphoenolpyruvate synthase; Validated; Region: PRK06464 685038005045 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 685038005046 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 685038005047 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 685038005048 PEP synthetase regulatory protein; Provisional; Region: PRK05339 685038005049 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 685038005050 Hemin uptake protein [Inorganic ion transport and metabolism]; Region: HemP; COG4256 685038005051 hypothetical protein; Validated; Region: PRK00029 685038005052 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 685038005053 NlpC/P60 family; Region: NLPC_P60; pfam00877 685038005054 ABC-type cobalamin transport system, ATPase component [Coenzyme metabolism]; Region: BtuD; COG4138 685038005055 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 685038005056 Walker A/P-loop; other site 685038005057 ATP binding site [chemical binding]; other site 685038005058 Q-loop/lid; other site 685038005059 ABC transporter signature motif; other site 685038005060 Walker B; other site 685038005061 D-loop; other site 685038005062 H-loop/switch region; other site 685038005063 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 685038005064 catalytic residues [active] 685038005065 dimer interface [polypeptide binding]; other site 685038005066 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 685038005067 ABC-ATPase subunit interface; other site 685038005068 dimer interface [polypeptide binding]; other site 685038005069 putative PBP binding regions; other site 685038005070 Alpha subunit of integration host factor (IHFA); Region: IHF_A; cd13835 685038005071 DNA binding site [nucleotide binding] 685038005072 dimer interface [polypeptide binding]; other site 685038005073 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 685038005074 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 685038005075 putative tRNA-binding site [nucleotide binding]; other site 685038005076 B3/4 domain; Region: B3_4; pfam03483 685038005077 tRNA synthetase B5 domain; Region: B5; smart00874 685038005078 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 685038005079 dimer interface [polypeptide binding]; other site 685038005080 motif 1; other site 685038005081 motif 3; other site 685038005082 motif 2; other site 685038005083 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 685038005084 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 685038005085 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 685038005086 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 685038005087 dimer interface [polypeptide binding]; other site 685038005088 motif 1; other site 685038005089 active site 685038005090 motif 2; other site 685038005091 motif 3; other site 685038005092 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 685038005093 23S rRNA binding site [nucleotide binding]; other site 685038005094 L21 binding site [polypeptide binding]; other site 685038005095 L13 binding site [polypeptide binding]; other site 685038005096 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 685038005097 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 685038005098 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 685038005099 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 685038005100 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 685038005101 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 685038005102 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 685038005103 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 685038005104 active site 685038005105 dimer interface [polypeptide binding]; other site 685038005106 motif 1; other site 685038005107 motif 2; other site 685038005108 motif 3; other site 685038005109 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 685038005110 anticodon binding site; other site 685038005111 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 685038005112 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 685038005113 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 685038005114 putative substrate binding site [chemical binding]; other site 685038005115 putative ATP binding site [chemical binding]; other site 685038005116 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 685038005117 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3001 685038005118 Phosphotransferase enzyme family; Region: APH; pfam01636 685038005119 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 685038005120 active site 685038005121 substrate binding site [chemical binding]; other site 685038005122 ATP binding site [chemical binding]; other site 685038005123 YniB-like protein; Region: YniB; pfam14002 685038005124 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 685038005125 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 685038005126 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 685038005127 motif II; other site 685038005128 inner membrane protein; Provisional; Region: PRK11648 685038005129 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 685038005130 cell division modulator; Provisional; Region: PRK10113 685038005131 hydroperoxidase II; Provisional; Region: katE; PRK11249 685038005132 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 685038005133 tetramer interface [polypeptide binding]; other site 685038005134 heme binding pocket [chemical binding]; other site 685038005135 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 685038005136 domain interactions; other site 685038005137 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 685038005138 putative active site [active] 685038005139 YdjC motif; other site 685038005140 Mg binding site [ion binding]; other site 685038005141 putative homodimer interface [polypeptide binding]; other site 685038005142 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 685038005143 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 685038005144 NAD binding site [chemical binding]; other site 685038005145 sugar binding site [chemical binding]; other site 685038005146 divalent metal binding site [ion binding]; other site 685038005147 tetramer (dimer of dimers) interface [polypeptide binding]; other site 685038005148 dimer interface [polypeptide binding]; other site 685038005149 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 685038005150 Cupin domain; Region: Cupin_2; cl17218 685038005151 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 685038005152 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 685038005153 methionine cluster; other site 685038005154 active site 685038005155 phosphorylation site [posttranslational modification] 685038005156 metal binding site [ion binding]; metal-binding site 685038005157 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 685038005158 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 685038005159 active site 685038005160 P-loop; other site 685038005161 phosphorylation site [posttranslational modification] 685038005162 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 685038005163 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 685038005164 homodimer interface [polypeptide binding]; other site 685038005165 NAD binding pocket [chemical binding]; other site 685038005166 ATP binding pocket [chemical binding]; other site 685038005167 Mg binding site [ion binding]; other site 685038005168 active-site loop [active] 685038005169 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 685038005170 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 685038005171 GIY-YIG motif/motif A; other site 685038005172 active site 685038005173 catalytic site [active] 685038005174 putative DNA binding site [nucleotide binding]; other site 685038005175 metal binding site [ion binding]; metal-binding site 685038005176 hypothetical protein; Provisional; Region: PRK11396 685038005177 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 685038005178 dimer interface [polypeptide binding]; other site 685038005179 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 685038005180 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 685038005181 putative active site [active] 685038005182 Zn binding site [ion binding]; other site 685038005183 succinylarginine dihydrolase; Provisional; Region: PRK13281 685038005184 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 685038005185 NAD(P) binding site [chemical binding]; other site 685038005186 catalytic residues [active] 685038005187 arginine succinyltransferase; Provisional; Region: PRK10456 685038005188 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 685038005189 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 685038005190 inhibitor-cofactor binding pocket; inhibition site 685038005191 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685038005192 catalytic residue [active] 685038005193 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 685038005194 putative catalytic site [active] 685038005195 putative phosphate binding site [ion binding]; other site 685038005196 active site 685038005197 metal binding site A [ion binding]; metal-binding site 685038005198 DNA binding site [nucleotide binding] 685038005199 putative AP binding site [nucleotide binding]; other site 685038005200 putative metal binding site B [ion binding]; other site 685038005201 Uncharacterized conserved protein [Function unknown]; Region: COG0398 685038005202 Uncharacterized conserved protein [Function unknown]; Region: COG0398 685038005203 Uncharacterized conserved protein [Function unknown]; Region: COG2128 685038005204 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 685038005205 hypothetical protein; Provisional; Region: PRK11622 685038005206 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 685038005207 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135 685038005208 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685038005209 putative PBP binding loops; other site 685038005210 ABC-ATPase subunit interface; other site 685038005211 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 685038005212 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685038005213 Walker A/P-loop; other site 685038005214 ATP binding site [chemical binding]; other site 685038005215 Q-loop/lid; other site 685038005216 ABC transporter signature motif; other site 685038005217 Walker B; other site 685038005218 D-loop; other site 685038005219 H-loop/switch region; other site 685038005220 Rhodanese Homology Domain; Region: RHOD; smart00450 685038005221 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 685038005222 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 685038005223 active site residue [active] 685038005224 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 685038005225 active site residue [active] 685038005226 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 685038005227 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 685038005228 active site 685038005229 8-oxo-dGMP binding site [chemical binding]; other site 685038005230 nudix motif; other site 685038005231 metal binding site [ion binding]; metal-binding site 685038005232 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 685038005233 glutamate dehydrogenase; Provisional; Region: PRK09414 685038005234 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 685038005235 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 685038005236 NAD(P) binding site [chemical binding]; other site 685038005237 DNA topoisomerase III; Provisional; Region: PRK07726 685038005238 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 685038005239 active site 685038005240 putative interdomain interaction site [polypeptide binding]; other site 685038005241 putative metal-binding site [ion binding]; other site 685038005242 putative nucleotide binding site [chemical binding]; other site 685038005243 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 685038005244 domain I; other site 685038005245 DNA binding groove [nucleotide binding] 685038005246 phosphate binding site [ion binding]; other site 685038005247 domain II; other site 685038005248 domain III; other site 685038005249 nucleotide binding site [chemical binding]; other site 685038005250 catalytic site [active] 685038005251 domain IV; other site 685038005252 selenophosphate synthetase; Provisional; Region: PRK00943 685038005253 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 685038005254 dimerization interface [polypeptide binding]; other site 685038005255 putative ATP binding site [chemical binding]; other site 685038005256 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 685038005257 putative FMN binding site [chemical binding]; other site 685038005258 protease 4; Provisional; Region: PRK10949 685038005259 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 685038005260 tandem repeat interface [polypeptide binding]; other site 685038005261 oligomer interface [polypeptide binding]; other site 685038005262 active site residues [active] 685038005263 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 685038005264 tandem repeat interface [polypeptide binding]; other site 685038005265 oligomer interface [polypeptide binding]; other site 685038005266 active site residues [active] 685038005267 cytoplasmic asparaginase I; Provisional; Region: ansA; PRK09461 685038005268 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 685038005269 active site 685038005270 homodimer interface [polypeptide binding]; other site 685038005271 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 685038005272 catalytic triad [active] 685038005273 metal binding site [ion binding]; metal-binding site 685038005274 conserved cis-peptide bond; other site 685038005275 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038005276 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 685038005277 putative substrate translocation pore; other site 685038005278 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 685038005279 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 685038005280 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 685038005281 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 685038005282 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 685038005283 active site 685038005284 catalytic tetrad [active] 685038005285 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 685038005286 substrate binding site [chemical binding]; other site 685038005287 ATP binding site [chemical binding]; other site 685038005288 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 685038005289 intersubunit interface [polypeptide binding]; other site 685038005290 active site 685038005291 zinc binding site [ion binding]; other site 685038005292 Na+ binding site [ion binding]; other site 685038005293 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 685038005294 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 685038005295 inhibitor binding site; inhibition site 685038005296 catalytic Zn binding site [ion binding]; other site 685038005297 structural Zn binding site [ion binding]; other site 685038005298 NADP binding site [chemical binding]; other site 685038005299 tetramer interface [polypeptide binding]; other site 685038005300 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038005301 Major Facilitator Superfamily; Region: MFS_1; pfam07690 685038005302 putative substrate translocation pore; other site 685038005303 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 685038005304 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 685038005305 putative NAD(P) binding site [chemical binding]; other site 685038005306 catalytic Zn binding site [ion binding]; other site 685038005307 structural Zn binding site [ion binding]; other site 685038005308 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 685038005309 methionine sulfoxide reductase B; Provisional; Region: PRK00222 685038005310 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 685038005311 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 685038005312 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 685038005313 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 685038005314 active site 685038005315 phosphate binding residues; other site 685038005316 catalytic residues [active] 685038005317 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 685038005318 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 685038005319 active site 685038005320 catalytic tetrad [active] 685038005321 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 685038005322 PrkA family serine protein kinase; Provisional; Region: PRK15455 685038005323 PrkA AAA domain; Region: AAA_PrkA; pfam08298 685038005324 Walker A motif; other site 685038005325 ATP binding site [chemical binding]; other site 685038005326 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 685038005327 Uncharacterized conserved protein [Function unknown]; Region: COG2718 685038005328 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 685038005329 metal ion-dependent adhesion site (MIDAS); other site 685038005330 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 685038005331 metal binding site [ion binding]; metal-binding site 685038005332 active site 685038005333 I-site; other site 685038005334 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 685038005335 metal binding site [ion binding]; metal-binding site 685038005336 active site 685038005337 I-site; other site 685038005338 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 685038005339 putative deacylase active site [active] 685038005340 Predicted membrane protein [Function unknown]; Region: COG2707 685038005341 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 685038005342 cyanate transporter; Region: CynX; TIGR00896 685038005343 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038005344 putative substrate translocation pore; other site 685038005345 Uncharacterized conserved protein [Function unknown]; Region: COG3189 685038005346 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 685038005347 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 685038005348 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 685038005349 metal binding site [ion binding]; metal-binding site 685038005350 active site 685038005351 I-site; other site 685038005352 hypothetical protein; Provisional; Region: PRK10457 685038005353 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 685038005354 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 685038005355 leucine export protein LeuE; Provisional; Region: PRK10958 685038005356 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 685038005357 ribonuclease D; Provisional; Region: PRK10829 685038005358 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 685038005359 catalytic site [active] 685038005360 putative active site [active] 685038005361 putative substrate binding site [chemical binding]; other site 685038005362 Helicase and RNase D C-terminal; Region: HRDC; smart00341 685038005363 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 685038005364 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 685038005365 acyl-activating enzyme (AAE) consensus motif; other site 685038005366 putative AMP binding site [chemical binding]; other site 685038005367 putative active site [active] 685038005368 putative CoA binding site [chemical binding]; other site 685038005369 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 685038005370 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 685038005371 Glycoprotease family; Region: Peptidase_M22; pfam00814 685038005372 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 685038005373 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cd09708 685038005374 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 685038005375 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 685038005376 homotrimer interaction site [polypeptide binding]; other site 685038005377 putative active site [active] 685038005378 Domain of unknown function (DUF1889); Region: DUF1889; pfam08986 685038005379 hypothetical protein; Provisional; Region: PRK05114 685038005380 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 685038005381 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 685038005382 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 685038005383 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 685038005384 putative active site [active] 685038005385 putative CoA binding site [chemical binding]; other site 685038005386 nudix motif; other site 685038005387 L-serine deaminase; Provisional; Region: PRK15023 685038005388 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 685038005389 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 685038005390 phage resistance protein; Provisional; Region: PRK10551 685038005391 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 685038005392 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 685038005393 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 685038005394 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 685038005395 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 685038005396 Transporter associated domain; Region: CorC_HlyC; smart01091 685038005397 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 685038005398 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 685038005399 active pocket/dimerization site; other site 685038005400 active site 685038005401 phosphorylation site [posttranslational modification] 685038005402 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 685038005403 active site 685038005404 phosphorylation site [posttranslational modification] 685038005405 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 685038005406 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 685038005407 hypothetical protein; Provisional; Region: PRK02913 685038005408 hypothetical protein; Provisional; Region: PRK11469 685038005409 Domain of unknown function DUF; Region: DUF204; pfam02659 685038005410 Domain of unknown function DUF; Region: DUF204; pfam02659 685038005411 Methyltransferase domain; Region: Methyltransf_31; pfam13847 685038005412 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685038005413 S-adenosylmethionine binding site [chemical binding]; other site 685038005414 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 685038005415 DNA-binding site [nucleotide binding]; DNA binding site 685038005416 RNA-binding motif; other site 685038005417 Protein of unknown function (DUF2627); Region: DUF2527; pfam10736 685038005418 YebO-like protein; Region: YebO; pfam13974 685038005419 PhoPQ regulatory protein; Provisional; Region: PRK10299 685038005420 YobH-like protein; Region: YobH; pfam13996 685038005421 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 685038005422 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 685038005423 dimerization interface [polypeptide binding]; other site 685038005424 putative Zn2+ binding site [ion binding]; other site 685038005425 putative DNA binding site [nucleotide binding]; other site 685038005426 Bacterial transcriptional regulator; Region: IclR; pfam01614 685038005427 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038005428 Major Facilitator Superfamily; Region: MFS_1; pfam07690 685038005429 putative substrate translocation pore; other site 685038005430 Predicted integral membrane protein [Function unknown]; Region: COG5521 685038005431 Transposase IS200 like; Region: Y1_Tnp; pfam01797 685038005432 heat shock protein HtpX; Provisional; Region: PRK05457 685038005433 carboxy-terminal protease; Provisional; Region: PRK11186 685038005434 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 685038005435 protein binding site [polypeptide binding]; other site 685038005436 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 685038005437 Catalytic dyad [active] 685038005438 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 685038005439 ProP expression regulator; Provisional; Region: PRK04950 685038005440 putative RNA binding sites [nucleotide binding]; other site 685038005441 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 685038005442 integral membrane protein, PqiA family; Region: pqiA_fam; TIGR00155 685038005443 Paraquat-inducible protein A; Region: PqiA; pfam04403 685038005444 Paraquat-inducible protein A; Region: PqiA; pfam04403 685038005445 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 685038005446 mce related protein; Region: MCE; pfam02470 685038005447 mce related protein; Region: MCE; pfam02470 685038005448 mce related protein; Region: MCE; pfam02470 685038005449 mce related protein; Region: MCE; pfam02470 685038005450 mce related protein; Region: MCE; pfam02470 685038005451 mce related protein; Region: MCE; pfam02470 685038005452 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 685038005453 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685038005454 S-adenosylmethionine binding site [chemical binding]; other site 685038005455 Uncharacterized conserved protein [Function unknown]; Region: COG3270 685038005456 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 685038005457 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 685038005458 serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439 685038005459 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 685038005460 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 685038005461 hypothetical protein; Provisional; Region: PRK10301 685038005462 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 685038005463 Predicted amidohydrolase [General function prediction only]; Region: COG0388 685038005464 exodeoxyribonuclease X; Provisional; Region: PRK07983 685038005465 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 685038005466 active site 685038005467 catalytic site [active] 685038005468 substrate binding site [chemical binding]; other site 685038005469 protease 2; Provisional; Region: PRK10115 685038005470 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 685038005471 Protein of unknown function (DUF533); Region: DUF533; pfam04391 685038005472 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 685038005473 putative metal binding site [ion binding]; other site 685038005474 hypothetical protein; Provisional; Region: PRK13680 685038005475 DNA damage-inducible protein YebG; Provisional; Region: PRK10061 685038005476 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 685038005477 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685038005478 ATP-grasp domain; Region: ATP-grasp; pfam02222 685038005479 Entner-Doudoroff aldolase; Region: eda; TIGR01182 685038005480 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 685038005481 active site 685038005482 intersubunit interface [polypeptide binding]; other site 685038005483 catalytic residue [active] 685038005484 phosphogluconate dehydratase; Validated; Region: PRK09054 685038005485 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 685038005486 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 685038005487 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 685038005488 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 685038005489 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 685038005490 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 685038005491 putative active site [active] 685038005492 pyruvate kinase; Provisional; Region: PRK05826 685038005493 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 685038005494 domain interfaces; other site 685038005495 active site 685038005496 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 685038005497 putative acyl-acceptor binding pocket; other site 685038005498 putative peptidase; Provisional; Region: PRK11649 685038005499 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 685038005500 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 685038005501 Peptidase family M23; Region: Peptidase_M23; pfam01551 685038005502 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 685038005503 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 685038005504 metal binding site [ion binding]; metal-binding site 685038005505 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 685038005506 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 685038005507 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 685038005508 ABC-ATPase subunit interface; other site 685038005509 dimer interface [polypeptide binding]; other site 685038005510 putative PBP binding regions; other site 685038005511 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 685038005512 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685038005513 Walker A motif; other site 685038005514 ATP binding site [chemical binding]; other site 685038005515 Walker B motif; other site 685038005516 arginine finger; other site 685038005517 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 685038005518 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 685038005519 RuvA N terminal domain; Region: RuvA_N; pfam01330 685038005520 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 685038005521 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 685038005522 hypothetical protein; Provisional; Region: PRK11470 685038005523 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 685038005524 active site 685038005525 putative DNA-binding cleft [nucleotide binding]; other site 685038005526 dimer interface [polypeptide binding]; other site 685038005527 hypothetical protein; Validated; Region: PRK00110 685038005528 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 685038005529 nudix motif; other site 685038005530 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 685038005531 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 685038005532 dimer interface [polypeptide binding]; other site 685038005533 anticodon binding site; other site 685038005534 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 685038005535 homodimer interface [polypeptide binding]; other site 685038005536 motif 1; other site 685038005537 active site 685038005538 motif 2; other site 685038005539 GAD domain; Region: GAD; pfam02938 685038005540 motif 3; other site 685038005541 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 685038005542 catalytic triad [active] 685038005543 conserved cis-peptide bond; other site 685038005544 hypothetical protein; Provisional; Region: PRK10302 685038005545 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 685038005546 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685038005547 S-adenosylmethionine binding site [chemical binding]; other site 685038005548 tRNA (mo5U34)-methyltransferase; Region: TIGR00452 685038005549 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685038005550 S-adenosylmethionine binding site [chemical binding]; other site 685038005551 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 685038005552 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 685038005553 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 685038005554 molybdopterin cofactor binding site [chemical binding]; other site 685038005555 substrate binding site [chemical binding]; other site 685038005556 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 685038005557 molybdopterin cofactor binding site; other site 685038005558 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 685038005559 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 685038005560 copper homeostasis protein CutC; Provisional; Region: PRK11572 685038005561 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 685038005562 putative metal binding site [ion binding]; other site 685038005563 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 685038005564 arginyl-tRNA synthetase; Region: argS; TIGR00456 685038005565 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 685038005566 active site 685038005567 HIGH motif; other site 685038005568 KMSK motif region; other site 685038005569 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 685038005570 tRNA binding surface [nucleotide binding]; other site 685038005571 anticodon binding site; other site 685038005572 Flagellar protein FlhE; Region: FlhE; pfam06366 685038005573 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 685038005574 FlhB HrpN YscU SpaS Family; Region: Bac_export_2; cl19167 685038005575 chemotaxis regulator CheZ; Provisional; Region: PRK11166 685038005576 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685038005577 active site 685038005578 phosphorylation site [posttranslational modification] 685038005579 intermolecular recognition site; other site 685038005580 dimerization interface [polypeptide binding]; other site 685038005581 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 685038005582 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685038005583 active site 685038005584 phosphorylation site [posttranslational modification] 685038005585 intermolecular recognition site; other site 685038005586 dimerization interface [polypeptide binding]; other site 685038005587 CheB methylesterase; Region: CheB_methylest; pfam01339 685038005588 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 685038005589 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 685038005590 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685038005591 S-adenosylmethionine binding site [chemical binding]; other site 685038005592 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 685038005593 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 685038005594 dimer interface [polypeptide binding]; other site 685038005595 ligand binding site [chemical binding]; other site 685038005596 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 685038005597 dimerization interface [polypeptide binding]; other site 685038005598 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 685038005599 dimer interface [polypeptide binding]; other site 685038005600 putative CheW interface [polypeptide binding]; other site 685038005601 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 685038005602 putative CheA interaction surface; other site 685038005603 chemotaxis protein CheA; Provisional; Region: PRK10547 685038005604 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 685038005605 putative binding surface; other site 685038005606 active site 685038005607 CheY binding; Region: CheY-binding; pfam09078 685038005608 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 685038005609 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685038005610 ATP binding site [chemical binding]; other site 685038005611 Mg2+ binding site [ion binding]; other site 685038005612 G-X-G motif; other site 685038005613 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 685038005614 flagellar motor protein MotB; Validated; Region: motB; PRK09041 685038005615 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 685038005616 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 685038005617 ligand binding site [chemical binding]; other site 685038005618 flagellar motor protein MotA; Validated; Region: PRK09110 685038005619 transcriptional activator FlhC; Provisional; Region: PRK12722 685038005620 transcriptional activator FlhD; Provisional; Region: PRK02909 685038005621 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 685038005622 Ligand Binding Site [chemical binding]; other site 685038005623 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 685038005624 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 685038005625 active site 685038005626 homotetramer interface [polypeptide binding]; other site 685038005627 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187 685038005628 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 685038005629 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 685038005630 TM-ABC transporter signature motif; other site 685038005631 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 685038005632 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 685038005633 Walker A/P-loop; other site 685038005634 ATP binding site [chemical binding]; other site 685038005635 Q-loop/lid; other site 685038005636 ABC transporter signature motif; other site 685038005637 Walker B; other site 685038005638 D-loop; other site 685038005639 H-loop/switch region; other site 685038005640 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 685038005641 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 685038005642 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 685038005643 ligand binding site [chemical binding]; other site 685038005644 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 685038005645 Ferritin-like domain; Region: Ferritin; pfam00210 685038005646 ferroxidase diiron center [ion binding]; other site 685038005647 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 685038005648 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 685038005649 Ferritin-like domain; Region: Ferritin; pfam00210 685038005650 ferroxidase diiron center [ion binding]; other site 685038005651 probable metal-binding protein; Region: matur_matur; TIGR03853 685038005652 tyrosine transporter TyrP; Provisional; Region: PRK15132 685038005653 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 685038005654 hypothetical protein; Provisional; Region: PRK10396 685038005655 yecA family protein; Region: ygfB_yecA; TIGR02292 685038005656 SEC-C motif; Region: SEC-C; cl19389 685038005657 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 685038005658 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 685038005659 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 685038005660 GIY-YIG motif/motif A; other site 685038005661 active site 685038005662 catalytic site [active] 685038005663 putative DNA binding site [nucleotide binding]; other site 685038005664 metal binding site [ion binding]; metal-binding site 685038005665 UvrB/uvrC motif; Region: UVR; pfam02151 685038005666 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 685038005667 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 685038005668 response regulator; Provisional; Region: PRK09483 685038005669 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685038005670 active site 685038005671 phosphorylation site [posttranslational modification] 685038005672 intermolecular recognition site; other site 685038005673 dimerization interface [polypeptide binding]; other site 685038005674 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 685038005675 DNA binding residues [nucleotide binding] 685038005676 dimerization interface [polypeptide binding]; other site 685038005677 hypothetical protein; Provisional; Region: PRK10613 685038005678 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 685038005679 Autoinducer binding domain; Region: Autoind_bind; pfam03472 685038005680 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 685038005681 DNA binding residues [nucleotide binding] 685038005682 dimerization interface [polypeptide binding]; other site 685038005683 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 685038005684 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 685038005685 Walker A/P-loop; other site 685038005686 ATP binding site [chemical binding]; other site 685038005687 Q-loop/lid; other site 685038005688 ABC transporter signature motif; other site 685038005689 Walker B; other site 685038005690 D-loop; other site 685038005691 H-loop/switch region; other site 685038005692 amino acid ABC transporter permease; Provisional; Region: PRK15100 685038005693 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685038005694 dimer interface [polypeptide binding]; other site 685038005695 conserved gate region; other site 685038005696 putative PBP binding loops; other site 685038005697 ABC-ATPase subunit interface; other site 685038005698 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 685038005699 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685038005700 catalytic residue [active] 685038005701 cystine transporter subunit; Provisional; Region: PRK11260 685038005702 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 685038005703 substrate binding pocket [chemical binding]; other site 685038005704 membrane-bound complex binding site; other site 685038005705 hinge residues; other site 685038005706 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 685038005707 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 685038005708 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 685038005709 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 685038005710 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 685038005711 DNA binding residues [nucleotide binding] 685038005712 flagellin; Validated; Region: PRK08026 685038005713 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 685038005714 Flagellin protein; Region: FliC; pfam12445 685038005715 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 685038005716 flagellar capping protein; Reviewed; Region: fliD; PRK08032 685038005717 Flagellar hook-associated protein 2 N-terminus; Region: FliD_N; pfam02465 685038005718 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 685038005719 Flagellar protein FliS; Region: FliS; cl00654 685038005720 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 685038005721 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 685038005722 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 685038005723 active site 685038005724 Na/Ca binding site [ion binding]; other site 685038005725 catalytic site [active] 685038005726 lipoprotein; Provisional; Region: PRK10397 685038005727 putative inner membrane protein; Provisional; Region: PRK11099 685038005728 Predicted transporter component [General function prediction only]; Region: COG2391 685038005729 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 685038005730 CPxP motif; other site 685038005731 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 685038005732 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 685038005733 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 685038005734 trimer interface [polypeptide binding]; other site 685038005735 eyelet of channel; other site 685038005736 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 685038005737 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 685038005738 substrate binding site [chemical binding]; other site 685038005739 multidrug efflux protein; Reviewed; Region: emrE; PRK09541 685038005740 flagellar hook-basal body complex protein FliE; Region: fliE; TIGR00205 685038005741 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 685038005742 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 685038005743 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 685038005744 flagellar motor switch protein FliG; Region: fliG; TIGR00207 685038005745 FliG N-terminal domain; Region: FliG_N; pfam14842 685038005746 FliG middle domain; Region: FliG_M; pfam14841 685038005747 FliG C-terminal domain; Region: FliG_C; pfam01706 685038005748 flagellar assembly protein H; Validated; Region: fliH; PRK05687 685038005749 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 685038005750 Flagellar assembly protein FliH; Region: FliH; pfam02108 685038005751 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 685038005752 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 685038005753 Walker A motif/ATP binding site; other site 685038005754 Walker B motif; other site 685038005755 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 685038005756 flagellar hook-length control protein; Provisional; Region: PRK10118 685038005757 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 685038005758 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 685038005759 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 685038005760 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 685038005761 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 685038005762 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 685038005763 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 685038005764 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 685038005765 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 685038005766 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 685038005767 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 685038005768 DNA binding residues [nucleotide binding] 685038005769 dimerization interface [polypeptide binding]; other site 685038005770 hypothetical protein; Provisional; Region: PRK10708 685038005771 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 685038005772 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 685038005773 mannosyl-3-phosphoglycerate phosphatase family; Region: HAD-SF-IIB-MPGP; TIGR01486 685038005774 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 685038005775 active site 685038005776 motif I; other site 685038005777 motif II; other site 685038005778 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 685038005779 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 685038005780 metal binding site [ion binding]; metal-binding site 685038005781 active site 685038005782 I-site; other site 685038005783 Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293 685038005784 hypothetical protein; Provisional; Region: PRK10062 685038005785 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 685038005786 EamA-like transporter family; Region: EamA; pfam00892 685038005787 EamA-like transporter family; Region: EamA; pfam00892 685038005788 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 685038005789 additional DNA contacts [nucleotide binding]; other site 685038005790 mismatch recognition site; other site 685038005791 active site 685038005792 zinc binding site [ion binding]; other site 685038005793 DNA intercalation site [nucleotide binding]; other site 685038005794 DNA cytosine methylase; Provisional; Region: PRK10458 685038005795 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 685038005796 cofactor binding site; other site 685038005797 DNA binding site [nucleotide binding] 685038005798 substrate interaction site [chemical binding]; other site 685038005799 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 685038005800 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 685038005801 Zn2+ binding site [ion binding]; other site 685038005802 Mg2+ binding site [ion binding]; other site 685038005803 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 685038005804 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 685038005805 trimer interface [polypeptide binding]; other site 685038005806 eyelet of channel; other site 685038005807 chaperone protein HchA; Provisional; Region: PRK04155 685038005808 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 685038005809 conserved cys residue [active] 685038005810 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 685038005811 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 685038005812 dimer interface [polypeptide binding]; other site 685038005813 phosphorylation site [posttranslational modification] 685038005814 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685038005815 ATP binding site [chemical binding]; other site 685038005816 Mg2+ binding site [ion binding]; other site 685038005817 G-X-G motif; other site 685038005818 transcriptional regulatory protein YedW; Provisional; Region: PRK11517 685038005819 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685038005820 active site 685038005821 phosphorylation site [posttranslational modification] 685038005822 intermolecular recognition site; other site 685038005823 dimerization interface [polypeptide binding]; other site 685038005824 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 685038005825 DNA binding site [nucleotide binding] 685038005826 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 685038005827 active site 685038005828 homotetramer interface [polypeptide binding]; other site 685038005829 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 685038005830 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 685038005831 Moco binding site; other site 685038005832 metal coordination site [ion binding]; other site 685038005833 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 685038005834 zinc/cadmium-binding protein; Provisional; Region: PRK10306 685038005835 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 685038005836 integrase; Provisional; Region: PRK09692 685038005837 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 685038005838 active site 685038005839 Int/Topo IB signature motif; other site 685038005840 salicylate synthase Irp9; Reviewed; Region: PRK06772 685038005841 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 685038005842 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038005843 putative substrate translocation pore; other site 685038005844 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 685038005845 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 685038005846 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 685038005847 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685038005848 Walker A/P-loop; other site 685038005849 ATP binding site [chemical binding]; other site 685038005850 Q-loop/lid; other site 685038005851 ABC transporter signature motif; other site 685038005852 Walker B; other site 685038005853 D-loop; other site 685038005854 H-loop/switch region; other site 685038005855 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 685038005856 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 685038005857 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685038005858 Walker A/P-loop; other site 685038005859 ATP binding site [chemical binding]; other site 685038005860 Q-loop/lid; other site 685038005861 ABC transporter signature motif; other site 685038005862 Walker B; other site 685038005863 D-loop; other site 685038005864 H-loop/switch region; other site 685038005865 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 685038005866 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 685038005867 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 685038005868 Condensation domain; Region: Condensation; pfam00668 685038005869 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 685038005870 Nonribosomal peptide synthase; Region: NRPS; pfam08415 685038005871 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 685038005872 acyl-activating enzyme (AAE) consensus motif; other site 685038005873 AMP binding site [chemical binding]; other site 685038005874 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685038005875 S-adenosylmethionine binding site [chemical binding]; other site 685038005876 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 685038005877 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 685038005878 Condensation domain; Region: Condensation; cl19241 685038005879 Nonribosomal peptide synthase; Region: NRPS; pfam08415 685038005880 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 685038005881 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 685038005882 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 685038005883 active site 685038005884 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 685038005885 Methyltransferase domain; Region: Methyltransf_12; pfam08242 685038005886 Methyltransferase domain; Region: Methyltransf_23; pfam13489 685038005887 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 685038005888 short chain dehydrogenase; Region: adh_short; pfam00106 685038005889 NADP binding site [chemical binding]; other site 685038005890 active site 685038005891 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 685038005892 Condensation domain; Region: Condensation; cl19241 685038005893 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 685038005894 Nonribosomal peptide synthase; Region: NRPS; pfam08415 685038005895 Methyltransferase domain; Region: Methyltransf_12; pfam08242 685038005896 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 685038005897 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 685038005898 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 685038005899 Oxidoreductase (NAD-binding), involved in siderophore biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PchG; COG4693 685038005900 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 685038005901 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 685038005902 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 685038005903 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 685038005904 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 685038005905 acyl-activating enzyme (AAE) consensus motif; other site 685038005906 active site 685038005907 AMP binding site [chemical binding]; other site 685038005908 substrate binding site [chemical binding]; other site 685038005909 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 685038005910 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 685038005911 N-terminal plug; other site 685038005912 ligand-binding site [chemical binding]; other site 685038005913 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 685038005914 potential frameshift: common BLAST hit: gi|117624169|ref|YP_853082.1| putative autotransporter 685038005915 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 685038005916 shikimate transporter; Provisional; Region: PRK09952 685038005917 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038005918 putative substrate translocation pore; other site 685038005919 AMP nucleosidase; Provisional; Region: PRK08292 685038005920 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 685038005921 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 685038005922 hypothetical protein; Provisional; Region: PRK12378 685038005923 MATE family multidrug exporter; Provisional; Region: PRK10189 685038005924 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 685038005925 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 685038005926 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685038005927 The C-terminal substrate binding domain of LysR-type transcriptional regulator Cbl, which is required for expression of sulfate starvation-inducible (ssi) genes, contains the type 2 periplasmic binding fold; Region: PBP2_Cbl; cd08444 685038005928 putative substrate binding site [chemical binding]; other site 685038005929 dimerization interface [polypeptide binding]; other site 685038005930 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 685038005931 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685038005932 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 685038005933 putative dimerization interface [polypeptide binding]; other site 685038005934 potential frameshift: common BLAST hit: gi|82543731|ref|YP_407678.1| putative P4-type integrase 685038005935 Transposase IS200 like; Region: Y1_Tnp; pfam01797 685038005936 Phage integrase, N-terminal; Region: Phage_int_SAM_2; pfam12834 685038005937 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 685038005938 active site 685038005939 catalytic residues [active] 685038005940 Int/Topo IB signature motif; other site 685038005941 DNA binding site [nucleotide binding] 685038005942 PemK-like protein; Region: PemK; cl00995 685038005943 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 685038005944 Winged helix-turn-helix DNA-binding; Region: HTH_35; cl17423 685038005945 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 685038005946 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 685038005947 Transposase [DNA replication, recombination, and repair]; Region: COG5433 685038005948 Transposase [DNA replication, recombination, and repair]; Region: COG5433 685038005949 AAA ATPase domain; Region: AAA_15; pfam13175 685038005950 AAA domain; Region: AAA_23; pfam13476 685038005951 AAA domain; Region: AAA_21; pfam13304 685038005952 Walker A/P-loop; other site 685038005953 ATP binding site [chemical binding]; other site 685038005954 AAA domain; Region: AAA_21; pfam13304 685038005955 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 685038005956 putative active site [active] 685038005957 putative metal-binding site [ion binding]; other site 685038005958 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 685038005959 Part of AAA domain; Region: AAA_19; pfam13245 685038005960 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; cl19402 685038005961 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 685038005962 tetramer interface [polypeptide binding]; other site 685038005963 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 685038005964 active site 685038005965 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 685038005966 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685038005967 NAD(P) binding site [chemical binding]; other site 685038005968 active site 685038005969 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 685038005970 substrate binding site [chemical binding]; other site 685038005971 hexamer interface [polypeptide binding]; other site 685038005972 metal binding site [ion binding]; metal-binding site 685038005973 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 685038005974 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 685038005975 active site 685038005976 P-loop; other site 685038005977 phosphorylation site [posttranslational modification] 685038005978 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 685038005979 active site 685038005980 phosphorylation site [posttranslational modification] 685038005981 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 685038005982 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 685038005983 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 685038005984 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 685038005985 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 685038005986 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 685038005987 active site 685038005988 P-loop; other site 685038005989 phosphorylation site [posttranslational modification] 685038005990 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 685038005991 active site 685038005992 phosphorylation site [posttranslational modification] 685038005993 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 685038005994 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 685038005995 L,D-transpeptidase; Provisional; Region: PRK10190 685038005996 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 685038005997 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 685038005998 putative dimer interface [polypeptide binding]; other site 685038005999 active site pocket [active] 685038006000 putative cataytic base [active] 685038006001 cobalamin 5'-phosphate synthase/cobalamin synthase; Region: cobS; TIGR00317 685038006002 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 685038006003 homotrimer interface [polypeptide binding]; other site 685038006004 Walker A motif; other site 685038006005 GTP binding site [chemical binding]; other site 685038006006 Walker B motif; other site 685038006007 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 685038006008 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 685038006009 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 685038006010 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 685038006011 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 685038006012 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 685038006013 amphipathic channel; other site 685038006014 Asn-Pro-Ala signature motifs; other site 685038006015 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 685038006016 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 685038006017 Hexamer interface [polypeptide binding]; other site 685038006018 Hexagonal pore residue; other site 685038006019 propanediol utilization protein PduB; Provisional; Region: PRK15415 685038006020 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 685038006021 putative hexamer interface [polypeptide binding]; other site 685038006022 putative hexagonal pore; other site 685038006023 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 685038006024 putative hexamer interface [polypeptide binding]; other site 685038006025 putative hexagonal pore; other site 685038006026 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687 685038006027 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 685038006028 alpha-beta subunit interface [polypeptide binding]; other site 685038006029 alpha-gamma subunit interface [polypeptide binding]; other site 685038006030 active site 685038006031 substrate and K+ binding site; other site 685038006032 K+ binding site [ion binding]; other site 685038006033 cobalamin binding site [chemical binding]; other site 685038006034 propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042 685038006035 Propanediol dehydratase, small subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduE; COG4910 685038006036 Cell division protein FtsA; Region: FtsA; cl17206 685038006037 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 685038006038 Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288 685038006039 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 685038006040 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 685038006041 Hexamer interface [polypeptide binding]; other site 685038006042 Hexagonal pore residue; other site 685038006043 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 685038006044 1,2-propanediol utilization protein K (PduK), Bacterial Micro-Compartment (BMC) domain repeat 1l; Region: BMC_PduK; cd07056 685038006045 putative hexamer interface [polypeptide binding]; other site 685038006046 putative hexagonal pore; other site 685038006047 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 685038006048 Propanediol utilisation protein PduL; Region: PduL; pfam06130 685038006049 Propanediol utilisation protein PduL; Region: PduL; pfam06130 685038006050 putative propanediol utilization protein PduM; Provisional; Region: PRK15428 685038006051 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 685038006052 Hexamer/Pentamer interface [polypeptide binding]; other site 685038006053 central pore; other site 685038006054 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 685038006055 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 685038006056 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 685038006057 putative catalytic cysteine [active] 685038006058 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 685038006059 putative active site [active] 685038006060 metal binding site [ion binding]; metal-binding site 685038006061 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 685038006062 SLBB domain; Region: SLBB; pfam10531 685038006063 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 685038006064 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 685038006065 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 685038006066 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 685038006067 putative hexamer interface [polypeptide binding]; other site 685038006068 putative hexagonal pore; other site 685038006069 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 685038006070 putative hexamer interface [polypeptide binding]; other site 685038006071 putative hexagonal pore; other site 685038006072 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 685038006073 putative hexamer interface [polypeptide binding]; other site 685038006074 putative hexagonal pore; other site 685038006075 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 685038006076 G1 box; other site 685038006077 GTP/Mg2+ binding site [chemical binding]; other site 685038006078 G2 box; other site 685038006079 G3 box; other site 685038006080 Switch II region; other site 685038006081 G4 box; other site 685038006082 G5 box; other site 685038006083 hypothetical protein; Provisional; Region: PRK05423 685038006084 Predicted membrane protein [Function unknown]; Region: COG1289 685038006085 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 685038006086 DNA gyrase inhibitor; Provisional; Region: PRK10016 685038006087 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 685038006088 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 685038006089 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 685038006090 exonuclease I; Provisional; Region: sbcB; PRK11779 685038006091 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 685038006092 active site 685038006093 catalytic site [active] 685038006094 substrate binding site [chemical binding]; other site 685038006095 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 685038006096 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 685038006097 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 685038006098 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685038006099 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 685038006100 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 685038006101 dimerization interface [polypeptide binding]; other site 685038006102 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 685038006103 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 685038006104 putative NAD(P) binding site [chemical binding]; other site 685038006105 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 685038006106 antitoxin YefM; Provisional; Region: PRK11409 685038006107 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 685038006108 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 685038006109 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 685038006110 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 685038006111 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 685038006112 NAD binding site [chemical binding]; other site 685038006113 dimerization interface [polypeptide binding]; other site 685038006114 product binding site; other site 685038006115 substrate binding site [chemical binding]; other site 685038006116 zinc binding site [ion binding]; other site 685038006117 catalytic residues [active] 685038006118 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 685038006119 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 685038006120 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685038006121 homodimer interface [polypeptide binding]; other site 685038006122 catalytic residue [active] 685038006123 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 685038006124 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 685038006125 active site 685038006126 motif I; other site 685038006127 motif II; other site 685038006128 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 685038006129 putative active site pocket [active] 685038006130 4-fold oligomerization interface [polypeptide binding]; other site 685038006131 metal binding residues [ion binding]; metal-binding site 685038006132 3-fold/trimer interface [polypeptide binding]; other site 685038006133 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 685038006134 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 685038006135 putative active site [active] 685038006136 oxyanion strand; other site 685038006137 catalytic triad [active] 685038006138 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 685038006139 catalytic residues [active] 685038006140 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 685038006141 substrate binding site [chemical binding]; other site 685038006142 glutamase interaction surface [polypeptide binding]; other site 685038006143 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 685038006144 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 685038006145 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 685038006146 metal binding site [ion binding]; metal-binding site 685038006147 chain length determinant protein WzzB; Provisional; Region: PRK15471 685038006148 Chain length determinant protein; Region: Wzz; pfam02706 685038006149 Protein-interacting V-domain of mammalian Alix and related domains; Region: V_Alix_like; cl14654 685038006150 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 685038006151 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 685038006152 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 685038006153 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 685038006154 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 685038006155 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 685038006156 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 685038006157 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 685038006158 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 685038006159 active site 685038006160 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 685038006161 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 685038006162 active site 685038006163 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 685038006164 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 685038006165 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 685038006166 active site 685038006167 colanic acid exporter; Provisional; Region: PRK10459 685038006168 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 685038006169 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 685038006170 active site 685038006171 tetramer interface; other site 685038006172 putative colanic acid biosynthesis protein; Provisional; Region: wcaM; PRK10123 685038006173 colanic acid biosynthesis glycosyltransferase WcaL; Region: wcaL; TIGR04005 685038006174 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 685038006175 putative ADP-binding pocket [chemical binding]; other site 685038006176 colanic acid biosynthesis pyruvyl transferase WcaK; Region: wcaK; TIGR04006 685038006177 colanic acid exporter; Provisional; Region: PRK10459 685038006178 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 685038006179 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 685038006180 CoA-binding domain; Region: CoA_binding_3; pfam13727 685038006181 Bacterial sugar transferase; Region: Bac_transf; pfam02397 685038006182 phosphomannomutase CpsG; Provisional; Region: PRK15414 685038006183 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 685038006184 active site 685038006185 substrate binding site [chemical binding]; other site 685038006186 metal binding site [ion binding]; metal-binding site 685038006187 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 685038006188 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 685038006189 Substrate binding site; other site 685038006190 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 685038006191 colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007 685038006192 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 685038006193 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 685038006194 active site 685038006195 GDP-Mannose binding site [chemical binding]; other site 685038006196 dimer interface [polypeptide binding]; other site 685038006197 modified nudix motif 685038006198 metal binding site [ion binding]; metal-binding site 685038006199 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 685038006200 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 685038006201 NADP binding site [chemical binding]; other site 685038006202 active site 685038006203 putative substrate binding site [chemical binding]; other site 685038006204 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 685038006205 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 685038006206 NADP-binding site; other site 685038006207 homotetramer interface [polypeptide binding]; other site 685038006208 substrate binding site [chemical binding]; other site 685038006209 homodimer interface [polypeptide binding]; other site 685038006210 active site 685038006211 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 685038006212 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 685038006213 putative trimer interface [polypeptide binding]; other site 685038006214 putative active site [active] 685038006215 putative substrate binding site [chemical binding]; other site 685038006216 putative CoA binding site [chemical binding]; other site 685038006217 putative glycosyl transferase; Provisional; Region: PRK10063 685038006218 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 685038006219 metal-binding site 685038006220 putative colanic acid biosynthesis protein; Provisional; Region: wcaD; cl08075 685038006221 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 685038006222 colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015 685038006223 putative acyl transferase; Provisional; Region: PRK10191 685038006224 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 685038006225 trimer interface [polypeptide binding]; other site 685038006226 active site 685038006227 substrate binding site [chemical binding]; other site 685038006228 CoA binding site [chemical binding]; other site 685038006229 putative glycosyl transferase; Provisional; Region: PRK10018 685038006230 colanic acid biosynthesis glycosyl transferase WcaA; Region: WcaA; TIGR04017 685038006231 active site 685038006232 tyrosine kinase; Provisional; Region: PRK11519 685038006233 Chain length determinant protein; Region: Wzz; pfam02706 685038006234 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 685038006235 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 685038006236 Low molecular weight phosphatase family; Region: LMWPc; cd00115 685038006237 active site 685038006238 polysaccharide export protein Wza; Provisional; Region: PRK15078 685038006239 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 685038006240 SLBB domain; Region: SLBB; pfam10531 685038006241 SLBB domain; Region: SLBB; pfam10531 685038006242 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 685038006243 FOG: CBS domain [General function prediction only]; Region: COG0517 685038006244 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 685038006245 Transporter associated domain; Region: CorC_HlyC; smart01091 685038006246 putative assembly protein; Provisional; Region: PRK10833 685038006247 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 685038006248 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 685038006249 trimer interface [polypeptide binding]; other site 685038006250 active site 685038006251 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 685038006252 ATP-binding site [chemical binding]; other site 685038006253 Sugar specificity; other site 685038006254 Pyrimidine base specificity; other site 685038006255 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 685038006256 putative diguanylate cyclase; Provisional; Region: PRK09776 685038006257 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 685038006258 putative active site [active] 685038006259 heme pocket [chemical binding]; other site 685038006260 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 685038006261 putative active site [active] 685038006262 heme pocket [chemical binding]; other site 685038006263 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 685038006264 putative active site [active] 685038006265 heme pocket [chemical binding]; other site 685038006266 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 685038006267 metal binding site [ion binding]; metal-binding site 685038006268 active site 685038006269 I-site; other site 685038006270 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 685038006271 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 685038006272 AlkA N-terminal domain; Region: AlkA_N; smart01009 685038006273 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 685038006274 minor groove reading motif; other site 685038006275 helix-hairpin-helix signature motif; other site 685038006276 substrate binding pocket [chemical binding]; other site 685038006277 active site 685038006278 putative chaperone; Provisional; Region: PRK11678 685038006279 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 685038006280 nucleotide binding site [chemical binding]; other site 685038006281 putative NEF/HSP70 interaction site [polypeptide binding]; other site 685038006282 SBD interface [polypeptide binding]; other site 685038006283 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248 685038006284 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 685038006285 substrate binding site [chemical binding]; other site 685038006286 activation loop (A-loop); other site 685038006287 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 685038006288 Protein phosphatase 2C; Region: PP2C_2; pfam13672 685038006289 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 685038006290 metal ion-dependent adhesion site (MIDAS); other site 685038006291 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 685038006292 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 685038006293 HlyD family secretion protein; Region: HlyD_3; pfam13437 685038006294 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 685038006295 MMPL family; Region: MMPL; cl14618 685038006296 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 685038006297 MMPL family; Region: MMPL; cl14618 685038006298 MMPL family; Region: MMPL; cl14618 685038006299 putative transporter; Provisional; Region: PRK10504 685038006300 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038006301 putative substrate translocation pore; other site 685038006302 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 685038006303 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 685038006304 dimerization interface [polypeptide binding]; other site 685038006305 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 685038006306 dimer interface [polypeptide binding]; other site 685038006307 phosphorylation site [posttranslational modification] 685038006308 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685038006309 ATP binding site [chemical binding]; other site 685038006310 Mg2+ binding site [ion binding]; other site 685038006311 G-X-G motif; other site 685038006312 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 685038006313 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685038006314 active site 685038006315 phosphorylation site [posttranslational modification] 685038006316 intermolecular recognition site; other site 685038006317 dimerization interface [polypeptide binding]; other site 685038006318 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 685038006319 DNA binding site [nucleotide binding] 685038006320 Uncharacterized conserved protein [Function unknown]; Region: COG3422 685038006321 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 685038006322 Domain of unknown function (DUF4034); Region: DUF4034; pfam13226 685038006323 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 685038006324 PcfJ-like protein; Region: PcfJ; pfam14284 685038006325 putative protease; Provisional; Region: PRK15452 685038006326 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 685038006327 lipid kinase; Reviewed; Region: PRK13054 685038006328 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 685038006329 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 685038006330 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 685038006331 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 685038006332 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 685038006333 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 685038006334 putative NAD(P) binding site [chemical binding]; other site 685038006335 catalytic Zn binding site [ion binding]; other site 685038006336 PTS system, galactitol-specific IIC component; Region: EIIC-GAT; TIGR00827 685038006337 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 685038006338 active site 685038006339 P-loop; other site 685038006340 phosphorylation site [posttranslational modification] 685038006341 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 685038006342 active site 685038006343 phosphorylation site [posttranslational modification] 685038006344 D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052 685038006345 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 685038006346 intersubunit interface [polypeptide binding]; other site 685038006347 active site 685038006348 zinc binding site [ion binding]; other site 685038006349 Na+ binding site [ion binding]; other site 685038006350 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 685038006351 putative active site; other site 685038006352 catalytic residue [active] 685038006353 Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825 685038006354 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038006355 putative substrate translocation pore; other site 685038006356 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 685038006357 YegV-like sugar kinase. Found only in bacteria, YegV-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YegV_kinase_like; cd01944 685038006358 substrate binding site [chemical binding]; other site 685038006359 ATP binding site [chemical binding]; other site 685038006360 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 685038006361 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 685038006362 DNA-binding site [nucleotide binding]; DNA binding site 685038006363 UTRA domain; Region: UTRA; pfam07702 685038006364 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 685038006365 YegX is an uncharacterized bacterial protein with a glycosyl hydrolase family 25 (GH25) catalytic domain that is similar in sequence to the CH-type (Chalaropsis-type) lysozymes of the GH25 family of endolysins; Region: GH25_YegX-like; cd06524 685038006366 active site 685038006367 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 685038006368 dimer interface [polypeptide binding]; other site 685038006369 substrate binding site [chemical binding]; other site 685038006370 ATP binding site [chemical binding]; other site 685038006371 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 685038006372 substrate binding site [chemical binding]; other site 685038006373 multimerization interface [polypeptide binding]; other site 685038006374 ATP binding site [chemical binding]; other site 685038006375 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 685038006376 putative metal binding site [ion binding]; other site 685038006377 putative homodimer interface [polypeptide binding]; other site 685038006378 putative homotetramer interface [polypeptide binding]; other site 685038006379 putative homodimer-homodimer interface [polypeptide binding]; other site 685038006380 putative allosteric switch controlling residues; other site 685038006381 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 685038006382 Predicted integral membrane protein [Function unknown]; Region: COG5455 685038006383 putative fimbrial-like adhesin protein StcD; Provisional; Region: PRK15252 685038006384 fimbrial outer membrane usher protein; Provisional; Region: PRK15217 685038006385 PapC N-terminal domain; Region: PapC_N; pfam13954 685038006386 Outer membrane usher protein; Region: Usher; pfam00577 685038006387 PapC C-terminal domain; Region: PapC_C; pfam13953 685038006388 putative fimbrial assembly chaperone protein StcB; Provisional; Region: PRK15253 685038006389 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 685038006390 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 685038006391 Fimbrial protein; Region: Fimbrial; cl01416 685038006392 Protein of unknown function (DUF2574); Region: DUF2574; pfam10836 685038006393 antiporter inner membrane protein; Provisional; Region: PRK11670 685038006394 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 685038006395 Walker A motif; other site 685038006396 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 685038006397 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 685038006398 active site 685038006399 HIGH motif; other site 685038006400 KMSKS motif; other site 685038006401 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 685038006402 tRNA binding surface [nucleotide binding]; other site 685038006403 anticodon binding site; other site 685038006404 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 685038006405 dimer interface [polypeptide binding]; other site 685038006406 putative tRNA-binding site [nucleotide binding]; other site 685038006407 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 685038006408 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 685038006409 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 685038006410 MoxR-like ATPases [General function prediction only]; Region: COG0714 685038006411 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685038006412 Walker A motif; other site 685038006413 ATP binding site [chemical binding]; other site 685038006414 Walker B motif; other site 685038006415 arginine finger; other site 685038006416 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 685038006417 metal ion-dependent adhesion site (MIDAS); other site 685038006418 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 685038006419 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 685038006420 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 685038006421 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 685038006422 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 685038006423 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685038006424 active site 685038006425 phosphorylation site [posttranslational modification] 685038006426 intermolecular recognition site; other site 685038006427 dimerization interface [polypeptide binding]; other site 685038006428 LytTr DNA-binding domain; Region: LytTR; pfam04397 685038006429 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 685038006430 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 685038006431 GAF domain; Region: GAF; pfam01590 685038006432 Histidine kinase; Region: His_kinase; pfam06580 685038006433 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685038006434 ATP binding site [chemical binding]; other site 685038006435 Mg2+ binding site [ion binding]; other site 685038006436 G-X-G motif; other site 685038006437 transcriptional regulator MirA; Provisional; Region: PRK15043 685038006438 Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763 685038006439 DNA binding residues [nucleotide binding] 685038006440 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 685038006441 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 685038006442 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685038006443 dimer interface [polypeptide binding]; other site 685038006444 conserved gate region; other site 685038006445 putative PBP binding loops; other site 685038006446 ABC-ATPase subunit interface; other site 685038006447 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 685038006448 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 685038006449 Walker A/P-loop; other site 685038006450 ATP binding site [chemical binding]; other site 685038006451 Q-loop/lid; other site 685038006452 ABC transporter signature motif; other site 685038006453 Walker B; other site 685038006454 D-loop; other site 685038006455 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 685038006456 H-loop/switch region; other site 685038006457 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685038006458 dimer interface [polypeptide binding]; other site 685038006459 conserved gate region; other site 685038006460 putative PBP binding loops; other site 685038006461 ABC-ATPase subunit interface; other site 685038006462 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 685038006463 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 685038006464 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 685038006465 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 685038006466 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 685038006467 D-lactate dehydrogenase; Provisional; Region: PRK11183 685038006468 FAD binding domain; Region: FAD_binding_4; cl19922 685038006469 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 685038006470 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 685038006471 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 685038006472 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 685038006473 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 685038006474 oxidoreductase; Provisional; Region: PRK12743 685038006475 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685038006476 NAD(P) binding site [chemical binding]; other site 685038006477 active site 685038006478 multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459 685038006479 Outer membrane efflux protein; Region: OEP; pfam02321 685038006480 Outer membrane efflux protein; Region: OEP; pfam02321 685038006481 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 685038006482 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 685038006483 FMN binding site [chemical binding]; other site 685038006484 active site 685038006485 catalytic residues [active] 685038006486 substrate binding site [chemical binding]; other site 685038006487 hypothetical protein; Provisional; Region: PRK01821 685038006488 hypothetical protein; Provisional; Region: PRK10711 685038006489 cytidine deaminase; Provisional; Region: PRK09027 685038006490 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 685038006491 active site 685038006492 catalytic motif [active] 685038006493 Zn binding site [ion binding]; other site 685038006494 Cytidine and deoxycytidylate deaminase zinc-binding region; Region: dCMP_cyt_deam_2; pfam08211 685038006495 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 685038006496 active site 685038006497 catalytic motif [active] 685038006498 Zn binding site [ion binding]; other site 685038006499 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 685038006500 putative active site [active] 685038006501 Protein of unknown function (DUF2542); Region: DUF2542; pfam10808 685038006502 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 685038006503 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 685038006504 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 685038006505 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 685038006506 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 685038006507 putative glutamate synthase subunit beta; Provisional; Region: PRK12770 685038006508 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 685038006509 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 685038006510 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 685038006511 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 685038006512 homodimer interface [polypeptide binding]; other site 685038006513 active site 685038006514 FMN binding site [chemical binding]; other site 685038006515 substrate binding site [chemical binding]; other site 685038006516 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 685038006517 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 685038006518 TM-ABC transporter signature motif; other site 685038006519 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 685038006520 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 685038006521 Walker A/P-loop; other site 685038006522 ATP binding site [chemical binding]; other site 685038006523 Q-loop/lid; other site 685038006524 ABC transporter signature motif; other site 685038006525 Walker B; other site 685038006526 D-loop; other site 685038006527 H-loop/switch region; other site 685038006528 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 685038006529 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 685038006530 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 685038006531 ligand binding site [chemical binding]; other site 685038006532 calcium binding site [ion binding]; other site 685038006533 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 685038006534 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 685038006535 DNA binding site [nucleotide binding] 685038006536 domain linker motif; other site 685038006537 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 685038006538 dimerization interface (closed form) [polypeptide binding]; other site 685038006539 ligand binding site [chemical binding]; other site 685038006540 Predicted membrane protein [Function unknown]; Region: COG2311 685038006541 hypothetical protein; Provisional; Region: PRK10835 685038006542 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 685038006543 homodecamer interface [polypeptide binding]; other site 685038006544 active site 685038006545 putative catalytic site residues [active] 685038006546 zinc binding site [ion binding]; other site 685038006547 GTP-CH-I/GFRP interaction surface; other site 685038006548 Predicted esterase [General function prediction only]; Region: COG0627 685038006549 S-formylglutathione hydrolase; Region: PLN02442 685038006550 catecholate siderophore receptor CirA; Provisional; Region: PRK10064 685038006551 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 685038006552 N-terminal plug; other site 685038006553 ligand-binding site [chemical binding]; other site 685038006554 lysine transporter; Provisional; Region: PRK10836 685038006555 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 685038006556 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 685038006557 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685038006558 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 685038006559 putative dimerization interface [polypeptide binding]; other site 685038006560 conserved hypothetical integral membrane protein; Region: TIGR00698 685038006561 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 685038006562 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 685038006563 AP (apurinic/apyrimidinic) site pocket; other site 685038006564 DNA interaction; other site 685038006565 Metal-binding active site; metal-binding site 685038006566 putative kinase; Provisional; Region: PRK09954 685038006567 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 685038006568 putative DNA binding site [nucleotide binding]; other site 685038006569 putative Zn2+ binding site [ion binding]; other site 685038006570 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 685038006571 substrate binding site [chemical binding]; other site 685038006572 ATP binding site [chemical binding]; other site 685038006573 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 685038006574 active site 685038006575 tetramer interface [polypeptide binding]; other site 685038006576 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 685038006577 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 685038006578 ligand binding site [chemical binding]; other site 685038006579 flexible hinge region; other site 685038006580 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 685038006581 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 685038006582 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 685038006583 Nucleoside recognition; Region: Gate; pfam07670 685038006584 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 685038006585 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 685038006586 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 685038006587 substrate binding site [chemical binding]; other site 685038006588 ATP binding site [chemical binding]; other site 685038006589 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 685038006590 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 685038006591 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 685038006592 active site 685038006593 P-loop; other site 685038006594 phosphorylation site [posttranslational modification] 685038006595 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 685038006596 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 685038006597 putative substrate binding site [chemical binding]; other site 685038006598 putative ATP binding site [chemical binding]; other site 685038006599 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 685038006600 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 685038006601 active site 685038006602 phosphorylation site [posttranslational modification] 685038006603 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 685038006604 dimerization domain swap beta strand [polypeptide binding]; other site 685038006605 regulatory protein interface [polypeptide binding]; other site 685038006606 active site 685038006607 regulatory phosphorylation site [posttranslational modification]; other site 685038006608 sugar efflux transporter B; Provisional; Region: PRK15011 685038006609 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038006610 putative substrate translocation pore; other site 685038006611 elongation factor P; Provisional; Region: PRK04542 685038006612 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 685038006613 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 685038006614 RNA binding site [nucleotide binding]; other site 685038006615 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 685038006616 RNA binding site [nucleotide binding]; other site 685038006617 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 685038006618 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 685038006619 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 685038006620 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 685038006621 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 685038006622 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 685038006623 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 685038006624 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 685038006625 active site 685038006626 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 685038006627 NlpC/P60 family; Region: NLPC_P60; pfam00877 685038006628 phage resistance protein; Provisional; Region: PRK10551 685038006629 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 685038006630 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 685038006631 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 685038006632 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 685038006633 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 685038006634 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685038006635 dimer interface [polypeptide binding]; other site 685038006636 conserved gate region; other site 685038006637 putative PBP binding loops; other site 685038006638 ABC-ATPase subunit interface; other site 685038006639 microcin C ABC transporter permease; Provisional; Region: PRK15021 685038006640 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685038006641 dimer interface [polypeptide binding]; other site 685038006642 conserved gate region; other site 685038006643 putative PBP binding loops; other site 685038006644 ABC-ATPase subunit interface; other site 685038006645 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 685038006646 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 685038006647 Walker A/P-loop; other site 685038006648 ATP binding site [chemical binding]; other site 685038006649 Q-loop/lid; other site 685038006650 ABC transporter signature motif; other site 685038006651 Walker B; other site 685038006652 D-loop; other site 685038006653 H-loop/switch region; other site 685038006654 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 685038006655 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 685038006656 Walker A/P-loop; other site 685038006657 ATP binding site [chemical binding]; other site 685038006658 Q-loop/lid; other site 685038006659 ABC transporter signature motif; other site 685038006660 Walker B; other site 685038006661 D-loop; other site 685038006662 H-loop/switch region; other site 685038006663 hypothetical protein; Provisional; Region: PRK11835 685038006664 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038006665 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 685038006666 putative substrate translocation pore; other site 685038006667 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 685038006668 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 685038006669 RNA binding surface [nucleotide binding]; other site 685038006670 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 685038006671 active site 685038006672 uracil binding [chemical binding]; other site 685038006673 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 685038006674 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 685038006675 ATP binding site [chemical binding]; other site 685038006676 putative Mg++ binding site [ion binding]; other site 685038006677 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 685038006678 nucleotide binding region [chemical binding]; other site 685038006679 ATP-binding site [chemical binding]; other site 685038006680 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 685038006681 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 685038006682 5S rRNA interface [nucleotide binding]; other site 685038006683 CTC domain interface [polypeptide binding]; other site 685038006684 L16 interface [polypeptide binding]; other site 685038006685 nucleoid-associated protein NdpA; Validated; Region: PRK00378 685038006686 hypothetical protein; Provisional; Region: PRK13689 685038006687 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 685038006688 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 685038006689 Sulfatase; Region: Sulfatase; pfam00884 685038006690 potential frameshift: common BLAST hit: gi|260856179|ref|YP_003230070.1| autotransporter outer membrane protein 685038006691 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 685038006692 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 685038006693 transcriptional regulator NarP; Provisional; Region: PRK10403 685038006694 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685038006695 active site 685038006696 phosphorylation site [posttranslational modification] 685038006697 intermolecular recognition site; other site 685038006698 dimerization interface [polypeptide binding]; other site 685038006699 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 685038006700 DNA binding residues [nucleotide binding] 685038006701 dimerization interface [polypeptide binding]; other site 685038006702 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 685038006703 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 685038006704 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 685038006705 binding surface 685038006706 TPR motif; other site 685038006707 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 685038006708 catalytic residues [active] 685038006709 central insert; other site 685038006710 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 685038006711 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13150 685038006712 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 685038006713 heme exporter protein CcmC; Region: ccmC; TIGR01191 685038006714 heme exporter protein CcmB; Region: ccmB; TIGR01190 685038006715 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 685038006716 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 685038006717 Walker A/P-loop; other site 685038006718 ATP binding site [chemical binding]; other site 685038006719 Q-loop/lid; other site 685038006720 ABC transporter signature motif; other site 685038006721 Walker B; other site 685038006722 D-loop; other site 685038006723 H-loop/switch region; other site 685038006724 cytochrome c-type protein NapC; Provisional; Region: PRK10617 685038006725 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 685038006726 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 685038006727 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 685038006728 4Fe-4S binding domain; Region: Fer4_5; pfam12801 685038006729 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 685038006730 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 685038006731 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 685038006732 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 685038006733 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 685038006734 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 685038006735 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 685038006736 [4Fe-4S] binding site [ion binding]; other site 685038006737 molybdopterin cofactor binding site; other site 685038006738 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 685038006739 molybdopterin cofactor binding site; other site 685038006740 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 685038006741 ferredoxin-type protein; Provisional; Region: PRK10194 685038006742 ferredoxin-type protein NapF; Region: napF; TIGR00402 685038006743 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 685038006744 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 685038006745 secondary substrate binding site; other site 685038006746 primary substrate binding site; other site 685038006747 inhibition loop; other site 685038006748 dimerization interface [polypeptide binding]; other site 685038006749 malate:quinone oxidoreductase; Validated; Region: PRK05257 685038006750 Predicted dehydrogenase [General function prediction only]; Region: COG0579 685038006751 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 685038006752 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 685038006753 Walker A/P-loop; other site 685038006754 ATP binding site [chemical binding]; other site 685038006755 Q-loop/lid; other site 685038006756 ABC transporter signature motif; other site 685038006757 Walker B; other site 685038006758 D-loop; other site 685038006759 H-loop/switch region; other site 685038006760 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 685038006761 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 685038006762 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 685038006763 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 685038006764 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 685038006765 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 685038006766 DNA binding site [nucleotide binding] 685038006767 active site 685038006768 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 685038006769 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 685038006770 trimer interface [polypeptide binding]; other site 685038006771 eyelet of channel; other site 685038006772 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 685038006773 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685038006774 ATP binding site [chemical binding]; other site 685038006775 Mg2+ binding site [ion binding]; other site 685038006776 G-X-G motif; other site 685038006777 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 685038006778 putative binding surface; other site 685038006779 active site 685038006780 transcriptional regulator RcsB; Provisional; Region: PRK10840 685038006781 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685038006782 active site 685038006783 phosphorylation site [posttranslational modification] 685038006784 intermolecular recognition site; other site 685038006785 dimerization interface [polypeptide binding]; other site 685038006786 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 685038006787 DNA binding residues [nucleotide binding] 685038006788 dimerization interface [polypeptide binding]; other site 685038006789 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 685038006790 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 685038006791 dimer interface [polypeptide binding]; other site 685038006792 phosphorylation site [posttranslational modification] 685038006793 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685038006794 ATP binding site [chemical binding]; other site 685038006795 Mg2+ binding site [ion binding]; other site 685038006796 G-X-G motif; other site 685038006797 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 685038006798 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685038006799 active site 685038006800 phosphorylation site [posttranslational modification] 685038006801 intermolecular recognition site; other site 685038006802 dimerization interface [polypeptide binding]; other site 685038006803 sensory histidine kinase AtoS; Provisional; Region: PRK11360 685038006804 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 685038006805 putative active site [active] 685038006806 heme pocket [chemical binding]; other site 685038006807 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 685038006808 dimer interface [polypeptide binding]; other site 685038006809 phosphorylation site [posttranslational modification] 685038006810 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685038006811 ATP binding site [chemical binding]; other site 685038006812 Mg2+ binding site [ion binding]; other site 685038006813 G-X-G motif; other site 685038006814 acetoacetate metabolism regulatory protein AtoC; Provisional; Region: PRK11361 685038006815 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685038006816 active site 685038006817 phosphorylation site [posttranslational modification] 685038006818 intermolecular recognition site; other site 685038006819 dimerization interface [polypeptide binding]; other site 685038006820 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685038006821 Walker A motif; other site 685038006822 ATP binding site [chemical binding]; other site 685038006823 Walker B motif; other site 685038006824 arginine finger; other site 685038006825 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 685038006826 acetyl-CoA:acetoacetyl-CoA transferase subunit alpha; Provisional; Region: PRK09920 685038006827 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 685038006828 Short chain fatty acid transporter; Region: SCFA_trans; pfam02667 685038006829 putative acyltransferase; Provisional; Region: PRK05790 685038006830 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 685038006831 dimer interface [polypeptide binding]; other site 685038006832 active site 685038006833 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 685038006834 Predicted secreted protein [Function unknown]; Region: COG5445 685038006835 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 685038006836 Predicted secreted protein [Function unknown]; Region: COG5445 685038006837 Stage II sporulation protein; Region: SpoIID; pfam08486 685038006838 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 685038006839 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 685038006840 MG2 domain; Region: A2M_N; pfam01835 685038006841 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 685038006842 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 685038006843 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 685038006844 Alpha-2-macroglobulin family; Region: A2M; pfam00207 685038006845 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 685038006846 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3234 685038006847 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4685 685038006848 DNA gyrase subunit A; Validated; Region: PRK05560 685038006849 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 685038006850 CAP-like domain; other site 685038006851 active site 685038006852 primary dimer interface [polypeptide binding]; other site 685038006853 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 685038006854 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 685038006855 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 685038006856 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 685038006857 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 685038006858 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 685038006859 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 685038006860 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685038006861 S-adenosylmethionine binding site [chemical binding]; other site 685038006862 adhesin; Provisional; Region: PRK09752 685038006863 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 685038006864 Autotransporter beta-domain; Region: Autotransporter; pfam03797 685038006865 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 685038006866 ATP cone domain; Region: ATP-cone; pfam03477 685038006867 Class I ribonucleotide reductase; Region: RNR_I; cd01679 685038006868 active site 685038006869 dimer interface [polypeptide binding]; other site 685038006870 catalytic residues [active] 685038006871 effector binding site; other site 685038006872 R2 peptide binding site; other site 685038006873 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 685038006874 dimer interface [polypeptide binding]; other site 685038006875 putative radical transfer pathway; other site 685038006876 diiron center [ion binding]; other site 685038006877 tyrosyl radical; other site 685038006878 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 685038006879 catalytic loop [active] 685038006880 iron binding site [ion binding]; other site 685038006881 hypothetical protein; Provisional; Region: PRK09902 685038006882 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 685038006883 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 685038006884 active site 685038006885 catalytic site [active] 685038006886 metal binding site [ion binding]; metal-binding site 685038006887 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 685038006888 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038006889 putative substrate translocation pore; other site 685038006890 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 685038006891 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 685038006892 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 685038006893 FAD binding domain; Region: FAD_binding_2; pfam00890 685038006894 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 685038006895 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 685038006896 Cysteine-rich domain; Region: CCG; pfam02754 685038006897 Cysteine-rich domain; Region: CCG; pfam02754 685038006898 hypothetical protein; Provisional; Region: PRK09956 685038006899 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 685038006900 hypothetical protein; Provisional; Region: PRK09956 685038006901 2-keto-3-deoxy-L-rhamnonate aldolase; Provisional; Region: PRK10128 685038006902 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 685038006903 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038006904 putative substrate translocation pore; other site 685038006905 L-rhamnonate dehydratase; Provisional; Region: PRK15440 685038006906 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 685038006907 putative active site pocket [active] 685038006908 putative metal binding site [ion binding]; other site 685038006909 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 685038006910 Transcriptional regulator [Transcription]; Region: IclR; COG1414 685038006911 Bacterial transcriptional regulator; Region: IclR; pfam01614 685038006912 hypothetical protein; Provisional; Region: PRK03673 685038006913 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 685038006914 putative MPT binding site; other site 685038006915 Competence-damaged protein; Region: CinA; cl00666 685038006916 YfaZ precursor; Region: YfaZ; pfam07437 685038006917 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 685038006918 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 685038006919 catalytic core [active] 685038006920 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 685038006921 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 685038006922 inhibitor-cofactor binding pocket; inhibition site 685038006923 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685038006924 catalytic residue [active] 685038006925 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 685038006926 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 685038006927 Ligand binding site; other site 685038006928 Putative Catalytic site; other site 685038006929 DXD motif; other site 685038006930 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 685038006931 ArnA, N-terminal formyltransferase domain; Region: FMT_core_ArnA_N; cd08644 685038006932 substrate binding site [chemical binding]; other site 685038006933 cosubstrate binding site; other site 685038006934 catalytic site [active] 685038006935 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 685038006936 active site 685038006937 hexamer interface [polypeptide binding]; other site 685038006938 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 685038006939 NAD binding site [chemical binding]; other site 685038006940 substrate binding site [chemical binding]; other site 685038006941 active site 685038006942 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 685038006943 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 685038006944 putative active site [active] 685038006945 putative catalytic site [active] 685038006946 putative Zn binding site [ion binding]; other site 685038006947 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 685038006948 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 685038006949 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 685038006950 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 685038006951 signal transduction protein PmrD; Provisional; Region: PRK15450 685038006952 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 685038006953 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 685038006954 acyl-activating enzyme (AAE) consensus motif; other site 685038006955 putative AMP binding site [chemical binding]; other site 685038006956 putative active site [active] 685038006957 putative CoA binding site [chemical binding]; other site 685038006958 O-succinylbenzoate synthase; Provisional; Region: PRK05105 685038006959 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 685038006960 active site 685038006961 dihydroxynaphthoic acid synthetase; Validated; Region: PRK07396 685038006962 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 685038006963 substrate binding site [chemical binding]; other site 685038006964 oxyanion hole (OAH) forming residues; other site 685038006965 trimer interface [polypeptide binding]; other site 685038006966 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 685038006967 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 685038006968 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 685038006969 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 685038006970 dimer interface [polypeptide binding]; other site 685038006971 tetramer interface [polypeptide binding]; other site 685038006972 PYR/PP interface [polypeptide binding]; other site 685038006973 TPP binding site [chemical binding]; other site 685038006974 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 685038006975 TPP-binding site; other site 685038006976 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 685038006977 isochorismate synthases; Region: isochor_syn; TIGR00543 685038006978 hypothetical protein; Provisional; Region: PRK10404 685038006979 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 685038006980 Coenzyme A binding pocket [chemical binding]; other site 685038006981 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 685038006982 deubiquitinase; Provisional; Region: PRK11836; cl08202 685038006983 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 685038006984 M28 Zn-Peptidases; Region: M28_like_1; cd05640 685038006985 metal binding site [ion binding]; metal-binding site 685038006986 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 685038006987 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 685038006988 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 685038006989 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 685038006990 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 685038006991 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 685038006992 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 685038006993 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 685038006994 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 685038006995 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 685038006996 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 685038006997 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 685038006998 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 685038006999 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 685038007000 NADH dehydrogenase subunit G; Validated; Region: PRK08166 685038007001 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 685038007002 catalytic loop [active] 685038007003 iron binding site [ion binding]; other site 685038007004 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 685038007005 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 685038007006 [4Fe-4S] binding site [ion binding]; other site 685038007007 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 685038007008 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 685038007009 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 685038007010 SLBB domain; Region: SLBB; pfam10531 685038007011 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 685038007012 NADH:ubiquinone oxidoreductase 24 kD subunit [Energy production and conversion]; Region: NuoE; COG1905 685038007013 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 685038007014 putative dimer interface [polypeptide binding]; other site 685038007015 [2Fe-2S] cluster binding site [ion binding]; other site 685038007016 NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; COG0852 685038007017 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 685038007018 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 685038007019 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 685038007020 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 685038007021 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 685038007022 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685038007023 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 685038007024 putative dimerization interface [polypeptide binding]; other site 685038007025 aminotransferase AlaT; Validated; Region: PRK09265 685038007026 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 685038007027 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685038007028 homodimer interface [polypeptide binding]; other site 685038007029 catalytic residue [active] 685038007030 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 685038007031 Zn2+ binding site [ion binding]; other site 685038007032 Mg2+ binding site [ion binding]; other site 685038007033 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 685038007034 transmembrane helices; other site 685038007035 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 685038007036 TrkA-C domain; Region: TrkA_C; pfam02080 685038007037 TrkA-C domain; Region: TrkA_C; pfam02080 685038007038 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 685038007039 putative phosphatase; Provisional; Region: PRK11587 685038007040 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 685038007041 active site 685038007042 motif I; other site 685038007043 motif II; other site 685038007044 hypothetical protein; Validated; Region: PRK05445 685038007045 hypothetical protein; Provisional; Region: PRK01816 685038007046 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 685038007047 phosphate acetyltransferase; Reviewed; Region: PRK05632 685038007048 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 685038007049 DRTGG domain; Region: DRTGG; pfam07085 685038007050 phosphate acetyltransferase; Region: pta; TIGR00651 685038007051 hypothetical protein; Provisional; Region: PRK11588 685038007052 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 685038007053 nudix motif; other site 685038007054 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 685038007055 active site 685038007056 metal binding site [ion binding]; metal-binding site 685038007057 homotetramer interface [polypeptide binding]; other site 685038007058 glutathione S-transferase; Provisional; Region: PRK15113 685038007059 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 685038007060 C-terminal domain interface [polypeptide binding]; other site 685038007061 GSH binding site (G-site) [chemical binding]; other site 685038007062 dimer interface [polypeptide binding]; other site 685038007063 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 685038007064 N-terminal domain interface [polypeptide binding]; other site 685038007065 putative dimer interface [polypeptide binding]; other site 685038007066 putative substrate binding pocket (H-site) [chemical binding]; other site 685038007067 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 685038007068 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 685038007069 C-terminal domain interface [polypeptide binding]; other site 685038007070 GSH binding site (G-site) [chemical binding]; other site 685038007071 dimer interface [polypeptide binding]; other site 685038007072 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 685038007073 N-terminal domain interface [polypeptide binding]; other site 685038007074 putative dimer interface [polypeptide binding]; other site 685038007075 active site 685038007076 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 685038007077 homooctamer interface [polypeptide binding]; other site 685038007078 active site 685038007079 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 685038007080 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 685038007081 putative NAD(P) binding site [chemical binding]; other site 685038007082 putative active site [active] 685038007083 hypothetical protein; Provisional; Region: PRK09956 685038007084 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 685038007085 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 685038007086 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 685038007087 Walker A/P-loop; other site 685038007088 ATP binding site [chemical binding]; other site 685038007089 Q-loop/lid; other site 685038007090 ABC transporter signature motif; other site 685038007091 Walker B; other site 685038007092 D-loop; other site 685038007093 H-loop/switch region; other site 685038007094 ABC-type arginine/histidine transport system, permease component [Amino acid transport and metabolism]; Region: ArtM; COG4160 685038007095 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685038007096 dimer interface [polypeptide binding]; other site 685038007097 conserved gate region; other site 685038007098 putative PBP binding loops; other site 685038007099 ABC-ATPase subunit interface; other site 685038007100 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 685038007101 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685038007102 dimer interface [polypeptide binding]; other site 685038007103 conserved gate region; other site 685038007104 putative PBP binding loops; other site 685038007105 ABC-ATPase subunit interface; other site 685038007106 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 685038007107 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 685038007108 substrate binding pocket [chemical binding]; other site 685038007109 membrane-bound complex binding site; other site 685038007110 hinge residues; other site 685038007111 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 685038007112 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 685038007113 substrate binding pocket [chemical binding]; other site 685038007114 membrane-bound complex binding site; other site 685038007115 hinge residues; other site 685038007116 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 685038007117 amidophosphoribosyltransferase; Provisional; Region: PRK09246 685038007118 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 685038007119 active site 685038007120 tetramer interface [polypeptide binding]; other site 685038007121 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 685038007122 active site 685038007123 colicin V production protein; Provisional; Region: PRK10845 685038007124 cell division protein DedD; Provisional; Region: PRK11633 685038007125 Sporulation related domain; Region: SPOR; pfam05036 685038007126 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 685038007127 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 685038007128 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 685038007129 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 685038007130 hypothetical protein; Provisional; Region: PRK10847 685038007131 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 685038007132 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 685038007133 dimerization interface 3.5A [polypeptide binding]; other site 685038007134 active site 685038007135 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 685038007136 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 685038007137 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 685038007138 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 685038007139 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 685038007140 ligand binding site [chemical binding]; other site 685038007141 NAD binding site [chemical binding]; other site 685038007142 catalytic site [active] 685038007143 homodimer interface [polypeptide binding]; other site 685038007144 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 685038007145 putative transporter; Provisional; Region: PRK12382 685038007146 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038007147 putative substrate translocation pore; other site 685038007148 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 685038007149 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 685038007150 dimer interface [polypeptide binding]; other site 685038007151 active site 685038007152 Uncharacterized conserved protein [Function unknown]; Region: COG4121 685038007153 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 685038007154 tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain; Region: MnmC_Cterm; TIGR03197 685038007155 YfcL protein; Region: YfcL; pfam08891 685038007156 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 685038007157 hypothetical protein; Provisional; Region: PRK10621 685038007158 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 685038007159 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 685038007160 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 685038007161 Tetramer interface [polypeptide binding]; other site 685038007162 active site 685038007163 FMN-binding site [chemical binding]; other site 685038007164 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK11805 685038007165 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685038007166 S-adenosylmethionine binding site [chemical binding]; other site 685038007167 hypothetical protein; Provisional; Region: PRK04946 685038007168 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 685038007169 Protein of unknown function (DUF2544); Region: DUF2544; pfam11245 685038007170 Fimbrial protein; Region: Fimbrial; cl01416 685038007171 Fimbrial protein; Region: Fimbrial; cl01416 685038007172 Fimbrial protein; Region: Fimbrial; cl01416 685038007173 putative fimbrial chaperone protein StfD; Provisional; Region: PRK15285 685038007174 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 685038007175 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 685038007176 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 685038007177 PapC N-terminal domain; Region: PapC_N; pfam13954 685038007178 Outer membrane usher protein; Region: Usher; pfam00577 685038007179 PapC C-terminal domain; Region: PapC_C; pfam13953 685038007180 Fimbrial protein; Region: Fimbrial; cl01416 685038007181 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 685038007182 catalytic core [active] 685038007183 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 685038007184 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 685038007185 substrate binding site [chemical binding]; other site 685038007186 oxyanion hole (OAH) forming residues; other site 685038007187 trimer interface [polypeptide binding]; other site 685038007188 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 685038007189 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 685038007190 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 685038007191 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 685038007192 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 685038007193 dimer interface [polypeptide binding]; other site 685038007194 active site 685038007195 conserved hypothetical protein; Region: TIGR00743 685038007196 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 685038007197 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 685038007198 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 685038007199 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 685038007200 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685038007201 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 685038007202 dimerization interface [polypeptide binding]; other site 685038007203 substrate binding pocket [chemical binding]; other site 685038007204 permease DsdX; Provisional; Region: PRK09921 685038007205 GntP family permease; Region: GntP_permease; pfam02447 685038007206 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 685038007207 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 685038007208 catalytic residue [active] 685038007209 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 685038007210 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038007211 putative substrate translocation pore; other site 685038007212 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 685038007213 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 685038007214 HlyD family secretion protein; Region: HlyD_3; pfam13437 685038007215 DNA-binding transcriptional activator EvgA; Provisional; Region: PRK09958 685038007216 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685038007217 active site 685038007218 phosphorylation site [posttranslational modification] 685038007219 intermolecular recognition site; other site 685038007220 dimerization interface [polypeptide binding]; other site 685038007221 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 685038007222 DNA binding residues [nucleotide binding] 685038007223 dimerization interface [polypeptide binding]; other site 685038007224 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 685038007225 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 685038007226 substrate binding pocket [chemical binding]; other site 685038007227 membrane-bound complex binding site; other site 685038007228 hinge residues; other site 685038007229 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 685038007230 substrate binding pocket [chemical binding]; other site 685038007231 membrane-bound complex binding site; other site 685038007232 hinge residues; other site 685038007233 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 685038007234 dimer interface [polypeptide binding]; other site 685038007235 phosphorylation site [posttranslational modification] 685038007236 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685038007237 ATP binding site [chemical binding]; other site 685038007238 Mg2+ binding site [ion binding]; other site 685038007239 G-X-G motif; other site 685038007240 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685038007241 active site 685038007242 phosphorylation site [posttranslational modification] 685038007243 intermolecular recognition site; other site 685038007244 dimerization interface [polypeptide binding]; other site 685038007245 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 685038007246 putative binding surface; other site 685038007247 active site 685038007248 putative CoA-transferase; Provisional; Region: PRK11430 685038007249 putative transporter YfdV; Provisional; Region: PRK09903 685038007250 oxalyl-CoA decarboxylase; Region: oxalate_oxc; TIGR03254 685038007251 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 685038007252 PYR/PP interface [polypeptide binding]; other site 685038007253 dimer interface [polypeptide binding]; other site 685038007254 TPP binding site [chemical binding]; other site 685038007255 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 685038007256 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 685038007257 TPP-binding site; other site 685038007258 dimer interface [polypeptide binding]; other site 685038007259 formyl-coenzyme A transferase; Provisional; Region: PRK05398 685038007260 hypothetical protein; Provisional; Region: PRK10316 685038007261 YfdX protein; Region: YfdX; pfam10938 685038007262 Protein of unknown function (DUF2545); Region: DUF2545; pfam10810 685038007263 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 685038007264 putative acyl-acceptor binding pocket; other site 685038007265 aminotransferase; Validated; Region: PRK08175 685038007266 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 685038007267 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685038007268 homodimer interface [polypeptide binding]; other site 685038007269 catalytic residue [active] 685038007270 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 685038007271 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 685038007272 GAF domain; Region: GAF; pfam01590 685038007273 Histidine kinase; Region: His_kinase; pfam06580 685038007274 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685038007275 ATP binding site [chemical binding]; other site 685038007276 Mg2+ binding site [ion binding]; other site 685038007277 G-X-G motif; other site 685038007278 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 685038007279 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685038007280 active site 685038007281 phosphorylation site [posttranslational modification] 685038007282 intermolecular recognition site; other site 685038007283 dimerization interface [polypeptide binding]; other site 685038007284 LytTr DNA-binding domain; Region: LytTR; pfam04397 685038007285 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 685038007286 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 685038007287 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 685038007288 dimerization domain swap beta strand [polypeptide binding]; other site 685038007289 regulatory protein interface [polypeptide binding]; other site 685038007290 active site 685038007291 regulatory phosphorylation site [posttranslational modification]; other site 685038007292 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 685038007293 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 685038007294 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 685038007295 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 685038007296 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 685038007297 active site 685038007298 phosphorylation site [posttranslational modification] 685038007299 M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638 685038007300 oligomer interface [polypeptide binding]; other site 685038007301 active site 685038007302 metal binding site [ion binding]; metal-binding site 685038007303 aminopeptidase; Provisional; Region: PRK09795 685038007304 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 685038007305 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 685038007306 active site 685038007307 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 685038007308 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 685038007309 active site 685038007310 P-loop; other site 685038007311 phosphorylation site [posttranslational modification] 685038007312 glucokinase; Provisional; Region: glk; PRK00292 685038007313 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 685038007314 nucleotide binding site [chemical binding]; other site 685038007315 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 685038007316 Cl- selectivity filter; other site 685038007317 Cl- binding residues [ion binding]; other site 685038007318 pore gating glutamate residue; other site 685038007319 dimer interface [polypeptide binding]; other site 685038007320 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 685038007321 manganese transport protein MntH; Reviewed; Region: PRK00701 685038007322 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 685038007323 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 685038007324 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 685038007325 Nucleoside recognition; Region: Gate; pfam07670 685038007326 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 685038007327 MASE1; Region: MASE1; pfam05231 685038007328 diguanylate cyclase; Region: GGDEF; smart00267 685038007329 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 685038007330 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 685038007331 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 685038007332 salt bridge; other site 685038007333 non-specific DNA binding site [nucleotide binding]; other site 685038007334 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 685038007335 sequence-specific DNA binding site [nucleotide binding]; other site 685038007336 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 685038007337 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 685038007338 active site 685038007339 HIGH motif; other site 685038007340 KMSKS motif; other site 685038007341 Protein of unknown function (DUF3150); Region: DUF3150; pfam11348 685038007342 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 685038007343 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685038007344 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 685038007345 putative dimerization interface [polypeptide binding]; other site 685038007346 putative substrate binding pocket [chemical binding]; other site 685038007347 XapX domain; Region: XapX; TIGR03510 685038007348 nucleoside transporter; Region: 2A0110; TIGR00889 685038007349 Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825 685038007350 Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005 685038007351 purine nucleoside phosphorylase; Provisional; Region: PRK08202 685038007352 hypothetical protein; Provisional; Region: PRK11528 685038007353 Transcriptional regulator [Transcription]; Region: LysR; COG0583 685038007354 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685038007355 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 685038007356 putative dimerization interface [polypeptide binding]; other site 685038007357 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 685038007358 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 685038007359 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 685038007360 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 685038007361 nucleotide binding pocket [chemical binding]; other site 685038007362 K-X-D-G motif; other site 685038007363 catalytic site [active] 685038007364 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 685038007365 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 685038007366 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 685038007367 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 685038007368 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 685038007369 Dimer interface [polypeptide binding]; other site 685038007370 BRCT sequence motif; other site 685038007371 cell division protein ZipA; Provisional; Region: PRK03427 685038007372 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 685038007373 FtsZ protein binding site [polypeptide binding]; other site 685038007374 putative sulfate transport protein CysZ; Validated; Region: PRK04949 685038007375 cysteine synthase; Region: PLN02565 685038007376 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 685038007377 dimer interface [polypeptide binding]; other site 685038007378 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685038007379 catalytic residue [active] 685038007380 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 685038007381 dimerization domain swap beta strand [polypeptide binding]; other site 685038007382 regulatory protein interface [polypeptide binding]; other site 685038007383 active site 685038007384 regulatory phosphorylation site [posttranslational modification]; other site 685038007385 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 685038007386 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 685038007387 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 685038007388 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 685038007389 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 685038007390 HPr interaction site; other site 685038007391 glycerol kinase (GK) interaction site [polypeptide binding]; other site 685038007392 active site 685038007393 phosphorylation site [posttranslational modification] 685038007394 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 685038007395 dimer interface [polypeptide binding]; other site 685038007396 pyridoxal binding site [chemical binding]; other site 685038007397 ATP binding site [chemical binding]; other site 685038007398 hypothetical protein; Provisional; Region: PRK10318 685038007399 cysteine synthase; Region: PLN02565 685038007400 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 685038007401 dimer interface [polypeptide binding]; other site 685038007402 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685038007403 catalytic residue [active] 685038007404 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 685038007405 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 685038007406 Walker A/P-loop; other site 685038007407 ATP binding site [chemical binding]; other site 685038007408 Q-loop/lid; other site 685038007409 ABC transporter signature motif; other site 685038007410 Walker B; other site 685038007411 D-loop; other site 685038007412 H-loop/switch region; other site 685038007413 TOBE-like domain; Region: TOBE_3; pfam12857 685038007414 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 685038007415 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685038007416 dimer interface [polypeptide binding]; other site 685038007417 conserved gate region; other site 685038007418 putative PBP binding loops; other site 685038007419 ABC-ATPase subunit interface; other site 685038007420 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 685038007421 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685038007422 dimer interface [polypeptide binding]; other site 685038007423 conserved gate region; other site 685038007424 putative PBP binding loops; other site 685038007425 ABC-ATPase subunit interface; other site 685038007426 thiosulfate transporter subunit; Provisional; Region: PRK10852 685038007427 short chain dehydrogenase; Provisional; Region: PRK08226 685038007428 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 685038007429 NAD binding site [chemical binding]; other site 685038007430 homotetramer interface [polypeptide binding]; other site 685038007431 homodimer interface [polypeptide binding]; other site 685038007432 active site 685038007433 N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274 685038007434 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 685038007435 putative active site [active] 685038007436 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 685038007437 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 685038007438 active site turn [active] 685038007439 phosphorylation site [posttranslational modification] 685038007440 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 685038007441 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 685038007442 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 685038007443 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 685038007444 putative acetyltransferase; Provisional; Region: PRK03624 685038007445 Uncharacterized conserved protein [Function unknown]; Region: COG3375 685038007446 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 685038007447 Coenzyme A binding pocket [chemical binding]; other site 685038007448 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 685038007449 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 685038007450 active site 685038007451 metal binding site [ion binding]; metal-binding site 685038007452 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 685038007453 transcriptional regulator EutR; Provisional; Region: PRK10130 685038007454 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 685038007455 carboxysome structural protein EutK; Provisional; Region: PRK15466 685038007456 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 685038007457 Hexamer interface [polypeptide binding]; other site 685038007458 Hexagonal pore residue; other site 685038007459 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 685038007460 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 685038007461 Hexamer interface [polypeptide binding]; other site 685038007462 Hexagonal pore residue; other site 685038007463 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 685038007464 putative hexamer interface [polypeptide binding]; other site 685038007465 putative hexagonal pore; other site 685038007466 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 685038007467 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 685038007468 Ethanolamine utilization protein, possible chaperonin protecting lyase from inhibition [Amino acid transport and metabolism]; Region: EutA; COG4819 685038007469 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 685038007470 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 685038007471 active site 685038007472 metal binding site [ion binding]; metal-binding site 685038007473 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 685038007474 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 685038007475 nucleotide binding site [chemical binding]; other site 685038007476 nucleotide binding site [chemical binding]; other site 685038007477 Cell division protein FtsA; Region: FtsA; cl17206 685038007478 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 685038007479 putative catalytic cysteine [active] 685038007480 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 685038007481 Hexamer/Pentamer interface [polypeptide binding]; other site 685038007482 central pore; other site 685038007483 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 685038007484 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 685038007485 Hexamer interface [polypeptide binding]; other site 685038007486 Hexagonal pore residue; other site 685038007487 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 685038007488 ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020 685038007489 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 685038007490 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 685038007491 G1 box; other site 685038007492 GTP/Mg2+ binding site [chemical binding]; other site 685038007493 G2 box; other site 685038007494 Switch I region; other site 685038007495 G3 box; other site 685038007496 Switch II region; other site 685038007497 G4 box; other site 685038007498 G5 box; other site 685038007499 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 685038007500 putative hexamer interface [polypeptide binding]; other site 685038007501 putative hexagonal pore; other site 685038007502 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 685038007503 Malic enzyme, N-terminal domain; Region: malic; pfam00390 685038007504 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 685038007505 putative NAD(P) binding site [chemical binding]; other site 685038007506 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 685038007507 transaldolase-like protein; Provisional; Region: PTZ00411 685038007508 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 685038007509 active site 685038007510 dimer interface [polypeptide binding]; other site 685038007511 catalytic residue [active] 685038007512 transketolase; Reviewed; Region: PRK12753 685038007513 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 685038007514 TPP-binding site [chemical binding]; other site 685038007515 dimer interface [polypeptide binding]; other site 685038007516 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 685038007517 PYR/PP interface [polypeptide binding]; other site 685038007518 dimer interface [polypeptide binding]; other site 685038007519 TPP binding site [chemical binding]; other site 685038007520 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 685038007521 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 685038007522 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 685038007523 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 685038007524 dimer interface [polypeptide binding]; other site 685038007525 ADP-ribose binding site [chemical binding]; other site 685038007526 active site 685038007527 nudix motif; other site 685038007528 metal binding site [ion binding]; metal-binding site 685038007529 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 685038007530 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 685038007531 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 685038007532 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 685038007533 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 685038007534 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 685038007535 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 685038007536 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 685038007537 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 685038007538 dimerization interface [polypeptide binding]; other site 685038007539 Histidine kinase; Region: HisKA_3; pfam07730 685038007540 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685038007541 ATP binding site [chemical binding]; other site 685038007542 Mg2+ binding site [ion binding]; other site 685038007543 G-X-G motif; other site 685038007544 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 685038007545 MMPL family; Region: MMPL; cl14618 685038007546 MMPL family; Region: MMPL; cl14618 685038007547 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 685038007548 putative catalytic residues [active] 685038007549 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 685038007550 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 685038007551 metal binding site [ion binding]; metal-binding site 685038007552 dimer interface [polypeptide binding]; other site 685038007553 hypothetical protein; Provisional; Region: PRK13664 685038007554 putative hydrolase; Provisional; Region: PRK11460 685038007555 Predicted esterase [General function prediction only]; Region: COG0400 685038007556 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 685038007557 Domain of unknown function (DUF1726); Region: DUF1726; pfam08351 685038007558 Helicase; Region: Helicase_RecD; pfam05127 685038007559 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 685038007560 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 685038007561 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 685038007562 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 685038007563 ATP binding site [chemical binding]; other site 685038007564 active site 685038007565 substrate binding site [chemical binding]; other site 685038007566 lipoprotein; Provisional; Region: PRK11679 685038007567 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 685038007568 dimer interface [polypeptide binding]; other site 685038007569 active site 685038007570 catalytic residue [active] 685038007571 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 685038007572 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 685038007573 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 685038007574 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 685038007575 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 685038007576 catalytic triad [active] 685038007577 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 685038007578 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 685038007579 Peptidase family M48; Region: Peptidase_M48; cl12018 685038007580 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 685038007581 catalytic residues [active] 685038007582 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 685038007583 DNA replication initiation factor; Provisional; Region: PRK08084 685038007584 uracil transporter; Provisional; Region: PRK10720 685038007585 uracil-xanthine permease; Region: ncs2; TIGR00801 685038007586 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 685038007587 active site 685038007588 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 685038007589 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 685038007590 dimerization interface [polypeptide binding]; other site 685038007591 putative ATP binding site [chemical binding]; other site 685038007592 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 685038007593 active site 685038007594 substrate binding site [chemical binding]; other site 685038007595 cosubstrate binding site; other site 685038007596 catalytic site [active] 685038007597 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 685038007598 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 685038007599 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 685038007600 Catalytic C-terminal domain, first repeat, of prokaryotic polyphosphate kinase 1 and similar proteins; Region: PLDc_PPK1_C1; cd09114 685038007601 domain interface [polypeptide binding]; other site 685038007602 active site 685038007603 catalytic site [active] 685038007604 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 685038007605 domain interface [polypeptide binding]; other site 685038007606 active site 685038007607 catalytic site [active] 685038007608 exopolyphosphatase; Provisional; Region: PRK10854 685038007609 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 685038007610 MASE1; Region: MASE1; pfam05231 685038007611 diguanylate cyclase; Region: GGDEF; smart00267 685038007612 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 685038007613 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 685038007614 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 685038007615 GMP synthase; Reviewed; Region: guaA; PRK00074 685038007616 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 685038007617 AMP/PPi binding site [chemical binding]; other site 685038007618 candidate oxyanion hole; other site 685038007619 catalytic triad [active] 685038007620 potential glutamine specificity residues [chemical binding]; other site 685038007621 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 685038007622 ATP Binding subdomain [chemical binding]; other site 685038007623 Ligand Binding sites [chemical binding]; other site 685038007624 Dimerization subdomain; other site 685038007625 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 685038007626 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 685038007627 active site 685038007628 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 685038007629 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 685038007630 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 685038007631 generic binding surface II; other site 685038007632 generic binding surface I; other site 685038007633 RatA-like protein; Provisional; Region: PRK15316 685038007634 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 685038007635 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 685038007636 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 685038007637 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 685038007638 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 685038007639 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 685038007640 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 685038007641 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 685038007642 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 685038007643 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 685038007644 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 685038007645 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 685038007646 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 685038007647 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 685038007648 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 685038007649 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 685038007650 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 685038007651 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 685038007652 intimin-like protein SinH; Provisional; Region: PRK15318 685038007653 intimin-like protein SinH; Provisional; Region: PRK15318 685038007654 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 685038007655 zinc-ribbons; Region: zinc-ribbons_6; pfam07191 685038007656 GTP-binding protein Der; Reviewed; Region: PRK00093 685038007657 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 685038007658 G1 box; other site 685038007659 GTP/Mg2+ binding site [chemical binding]; other site 685038007660 Switch I region; other site 685038007661 G2 box; other site 685038007662 Switch II region; other site 685038007663 G3 box; other site 685038007664 G4 box; other site 685038007665 G5 box; other site 685038007666 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 685038007667 G1 box; other site 685038007668 GTP/Mg2+ binding site [chemical binding]; other site 685038007669 Switch I region; other site 685038007670 G2 box; other site 685038007671 G3 box; other site 685038007672 Switch II region; other site 685038007673 G4 box; other site 685038007674 G5 box; other site 685038007675 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714 685038007676 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 685038007677 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cd00216 685038007678 Trp docking motif [polypeptide binding]; other site 685038007679 active site 685038007680 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 685038007681 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 685038007682 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 685038007683 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 685038007684 dimer interface [polypeptide binding]; other site 685038007685 motif 1; other site 685038007686 active site 685038007687 motif 2; other site 685038007688 motif 3; other site 685038007689 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 685038007690 anticodon binding site; other site 685038007691 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 685038007692 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 685038007693 cytoskeletal protein RodZ; Provisional; Region: PRK10856 685038007694 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 685038007695 non-specific DNA binding site [nucleotide binding]; other site 685038007696 salt bridge; other site 685038007697 sequence-specific DNA binding site [nucleotide binding]; other site 685038007698 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 685038007699 23S rRNA m2A2503 methyltransferase; Region: TIGR00048 685038007700 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 685038007701 FeS/SAM binding site; other site 685038007702 Nucleoside diphosphate kinase; Region: NDK; pfam00334 685038007703 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 685038007704 active site 685038007705 multimer interface [polypeptide binding]; other site 685038007706 penicillin-binding protein 1C; Provisional; Region: PRK11240 685038007707 Transglycosylase; Region: Transgly; pfam00912 685038007708 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 685038007709 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 685038007710 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 685038007711 MG2 domain; Region: A2M_N; pfam01835 685038007712 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 685038007713 Alpha-2-macroglobulin family; Region: A2M; pfam00207 685038007714 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 685038007715 surface patch; other site 685038007716 thioester region; other site 685038007717 specificity defining residues; other site 685038007718 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 685038007719 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 685038007720 active site residue [active] 685038007721 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 685038007722 active site residue [active] 685038007723 SseB protein N-terminal domain; Region: SseB; pfam07179 685038007724 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 685038007725 SseB protein C-terminal domain; Region: SseB_C; pfam14581 685038007726 aminopeptidase B; Provisional; Region: PRK05015 685038007727 Peptidase; Region: DUF3663; pfam12404 685038007728 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 685038007729 interface (dimer of trimers) [polypeptide binding]; other site 685038007730 Substrate-binding/catalytic site; other site 685038007731 Zn-binding sites [ion binding]; other site 685038007732 hypothetical protein; Provisional; Region: PRK10721 685038007733 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 685038007734 catalytic loop [active] 685038007735 iron binding site [ion binding]; other site 685038007736 chaperone protein HscA; Provisional; Region: hscA; PRK05183 685038007737 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 685038007738 nucleotide binding site [chemical binding]; other site 685038007739 putative NEF/HSP70 interaction site [polypeptide binding]; other site 685038007740 SBD interface [polypeptide binding]; other site 685038007741 co-chaperone HscB; Provisional; Region: hscB; PRK05014 685038007742 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 685038007743 HSP70 interaction site [polypeptide binding]; other site 685038007744 HSCB C-terminal oligomerization domain; Region: HSCB_C; pfam07743 685038007745 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 685038007746 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 685038007747 trimerization site [polypeptide binding]; other site 685038007748 active site 685038007749 cysteine desulfurase; Provisional; Region: PRK14012 685038007750 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 685038007751 catalytic residue [active] 685038007752 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 685038007753 Rrf2 family protein; Region: rrf2_super; TIGR00738 685038007754 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 685038007755 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 685038007756 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 685038007757 active site 685038007758 dimerization interface [polypeptide binding]; other site 685038007759 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 685038007760 Putative lysophospholipase; Region: Hydrolase_4; cl19140 685038007761 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 685038007762 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 685038007763 PRD domain; Region: PRD; pfam00874 685038007764 PRD domain; Region: PRD; pfam00874 685038007765 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038007766 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 685038007767 putative substrate translocation pore; other site 685038007768 Predicted membrane protein [Function unknown]; Region: COG2259 685038007769 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 685038007770 active site 685038007771 catalytic residues [active] 685038007772 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 685038007773 L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239 685038007774 putative NAD(P) binding site [chemical binding]; other site 685038007775 catalytic Zn binding site [ion binding]; other site 685038007776 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 685038007777 TM-ABC transporter signature motif; other site 685038007778 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 685038007779 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 685038007780 Walker A/P-loop; other site 685038007781 ATP binding site [chemical binding]; other site 685038007782 Q-loop/lid; other site 685038007783 ABC transporter signature motif; other site 685038007784 Walker B; other site 685038007785 D-loop; other site 685038007786 H-loop/switch region; other site 685038007787 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 685038007788 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 685038007789 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 685038007790 ligand binding site [chemical binding]; other site 685038007791 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 685038007792 TPR motif; other site 685038007793 binding surface 685038007794 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 685038007795 binding surface 685038007796 TPR motif; other site 685038007797 TPR repeat; Region: TPR_11; pfam13414 685038007798 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 685038007799 TPR motif; other site 685038007800 binding surface 685038007801 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 685038007802 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 685038007803 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 685038007804 nucleotide binding site [chemical binding]; other site 685038007805 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 685038007806 dimer interface [polypeptide binding]; other site 685038007807 active site 685038007808 glycine-pyridoxal phosphate binding site [chemical binding]; other site 685038007809 folate binding site [chemical binding]; other site 685038007810 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 685038007811 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 685038007812 heme-binding site [chemical binding]; other site 685038007813 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 685038007814 FAD binding pocket [chemical binding]; other site 685038007815 FAD binding motif [chemical binding]; other site 685038007816 phosphate binding motif [ion binding]; other site 685038007817 beta-alpha-beta structure motif; other site 685038007818 NAD binding pocket [chemical binding]; other site 685038007819 Heme binding pocket [chemical binding]; other site 685038007820 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 685038007821 response regulator GlrR; Provisional; Region: PRK15115 685038007822 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685038007823 active site 685038007824 phosphorylation site [posttranslational modification] 685038007825 intermolecular recognition site; other site 685038007826 dimerization interface [polypeptide binding]; other site 685038007827 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685038007828 Walker A motif; other site 685038007829 ATP binding site [chemical binding]; other site 685038007830 Walker B motif; other site 685038007831 arginine finger; other site 685038007832 hypothetical protein; Provisional; Region: PRK10722 685038007833 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 685038007834 HAMP domain; Region: HAMP; pfam00672 685038007835 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 685038007836 dimer interface [polypeptide binding]; other site 685038007837 phosphorylation site [posttranslational modification] 685038007838 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685038007839 ATP binding site [chemical binding]; other site 685038007840 Mg2+ binding site [ion binding]; other site 685038007841 G-X-G motif; other site 685038007842 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 685038007843 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 685038007844 dimerization interface [polypeptide binding]; other site 685038007845 ATP binding site [chemical binding]; other site 685038007846 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 685038007847 dimerization interface [polypeptide binding]; other site 685038007848 ATP binding site [chemical binding]; other site 685038007849 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 685038007850 putative active site [active] 685038007851 catalytic triad [active] 685038007852 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 685038007853 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 685038007854 substrate binding pocket [chemical binding]; other site 685038007855 membrane-bound complex binding site; other site 685038007856 hinge residues; other site 685038007857 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 685038007858 N-acetyl-D-glucosamine binding site [chemical binding]; other site 685038007859 catalytic residue [active] 685038007860 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 685038007861 nucleoside/Zn binding site; other site 685038007862 dimer interface [polypeptide binding]; other site 685038007863 catalytic motif [active] 685038007864 hypothetical protein; Provisional; Region: PRK11590 685038007865 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 685038007866 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 685038007867 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 685038007868 putative active site [active] 685038007869 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 685038007870 holo-[acyl-carrier-protein] synthase; Region: acpS; TIGR00516 685038007871 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 685038007872 active site 685038007873 hydrophilic channel; other site 685038007874 dimerization interface [polypeptide binding]; other site 685038007875 catalytic residues [active] 685038007876 active site lid [active] 685038007877 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 685038007878 Recombination protein O N terminal; Region: RecO_N; pfam11967 685038007879 Recombination protein O C terminal; Region: RecO_C; pfam02565 685038007880 GTPase Era; Reviewed; Region: era; PRK00089 685038007881 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 685038007882 G1 box; other site 685038007883 GTP/Mg2+ binding site [chemical binding]; other site 685038007884 Switch I region; other site 685038007885 G2 box; other site 685038007886 Switch II region; other site 685038007887 G3 box; other site 685038007888 G4 box; other site 685038007889 G5 box; other site 685038007890 KH domain; Region: KH_2; pfam07650 685038007891 ribonuclease III; Reviewed; Region: rnc; PRK00102 685038007892 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 685038007893 dimerization interface [polypeptide binding]; other site 685038007894 active site 685038007895 metal binding site [ion binding]; metal-binding site 685038007896 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 685038007897 dsRNA binding site [nucleotide binding]; other site 685038007898 signal peptidase I; Provisional; Region: PRK10861 685038007899 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 685038007900 Catalytic site [active] 685038007901 GTP-binding protein LepA; Provisional; Region: PRK05433 685038007902 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 685038007903 G1 box; other site 685038007904 putative GEF interaction site [polypeptide binding]; other site 685038007905 GTP/Mg2+ binding site [chemical binding]; other site 685038007906 Switch I region; other site 685038007907 G2 box; other site 685038007908 G3 box; other site 685038007909 Switch II region; other site 685038007910 G4 box; other site 685038007911 G5 box; other site 685038007912 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 685038007913 Elongation Factor G, domain II; Region: EFG_II; pfam14492 685038007914 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 685038007915 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 685038007916 SoxR reducing system protein RseC; Provisional; Region: PRK10862 685038007917 anti-sigma E factor; Provisional; Region: rseB; PRK09455 685038007918 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 685038007919 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 685038007920 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 685038007921 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 685038007922 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 685038007923 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 685038007924 DNA binding residues [nucleotide binding] 685038007925 L-aspartate oxidase; Provisional; Region: PRK09077 685038007926 L-aspartate oxidase; Provisional; Region: PRK06175 685038007927 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 685038007928 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 685038007929 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685038007930 S-adenosylmethionine binding site [chemical binding]; other site 685038007931 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 685038007932 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 685038007933 ATP binding site [chemical binding]; other site 685038007934 Mg++ binding site [ion binding]; other site 685038007935 motif III; other site 685038007936 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 685038007937 nucleotide binding region [chemical binding]; other site 685038007938 ATP-binding site [chemical binding]; other site 685038007939 Transcriptional regulator [Transcription]; Region: LysR; COG0583 685038007940 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685038007941 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 685038007942 dimerization interface [polypeptide binding]; other site 685038007943 cysteine/O-acetylserine exporter; Provisional; Region: PRK10323 685038007944 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 685038007945 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 685038007946 ligand binding site [chemical binding]; other site 685038007947 active site 685038007948 UGI interface [polypeptide binding]; other site 685038007949 catalytic site [active] 685038007950 putative methyltransferase; Provisional; Region: PRK10864 685038007951 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 685038007952 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 685038007953 thioredoxin 2; Provisional; Region: PRK10996 685038007954 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 685038007955 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 685038007956 catalytic residues [active] 685038007957 Uncharacterized conserved protein [Function unknown]; Region: COG3148 685038007958 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 685038007959 CoA binding domain; Region: CoA_binding_2; pfam13380 685038007960 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 685038007961 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 685038007962 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 685038007963 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 685038007964 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 685038007965 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 685038007966 domain interface [polypeptide binding]; other site 685038007967 putative active site [active] 685038007968 catalytic site [active] 685038007969 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 685038007970 domain interface [polypeptide binding]; other site 685038007971 putative active site [active] 685038007972 catalytic site [active] 685038007973 lipoprotein; Provisional; Region: PRK10759 685038007974 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 685038007975 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038007976 putative substrate translocation pore; other site 685038007977 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl19066 685038007978 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 685038007979 helix-hairpin-helix signature motif; other site 685038007980 Transposase; Region: DEDD_Tnp_IS110; pfam01548 685038007981 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 685038007982 HTH-like domain; Region: HTH_21; pfam13276 685038007983 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 685038007984 Integrase core domain; Region: rve; pfam00665 685038007985 Integrase core domain; Region: rve_2; pfam13333 685038007986 potential frameshift: common BLAST hit: gi|110644430|ref|YP_672160.1| IS transposase 685038007987 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 685038007988 Helix-turn-helix domain; Region: HTH_28; pfam13518 685038007989 protein disaggregation chaperone; Provisional; Region: PRK10865 685038007990 Clp amino terminal domain; Region: Clp_N; pfam02861 685038007991 Clp amino terminal domain; Region: Clp_N; pfam02861 685038007992 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685038007993 Walker A motif; other site 685038007994 ATP binding site [chemical binding]; other site 685038007995 Walker B motif; other site 685038007996 arginine finger; other site 685038007997 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685038007998 Walker A motif; other site 685038007999 ATP binding site [chemical binding]; other site 685038008000 Walker B motif; other site 685038008001 arginine finger; other site 685038008002 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 685038008003 hypothetical protein; Provisional; Region: PRK10723 685038008004 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 685038008005 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 685038008006 RNA binding surface [nucleotide binding]; other site 685038008007 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 685038008008 active site 685038008009 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 685038008010 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 685038008011 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 685038008012 30S subunit binding site; other site 685038008013 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 685038008014 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 685038008015 Prephenate dehydratase; Region: PDT; pfam00800 685038008016 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 685038008017 putative L-Phe binding site [chemical binding]; other site 685038008018 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 685038008019 Chorismate mutase type II; Region: CM_2; cl00693 685038008020 prephenate dehydrogenase; Validated; Region: PRK08507 685038008021 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 685038008022 lipoprotein; Provisional; Region: PRK11443 685038008023 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 685038008024 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 685038008025 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 685038008026 metal binding site [ion binding]; metal-binding site 685038008027 active site 685038008028 I-site; other site 685038008029 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 685038008030 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 685038008031 ligand binding site [chemical binding]; other site 685038008032 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 685038008033 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 685038008034 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 685038008035 RimM N-terminal domain; Region: RimM; pfam01782 685038008036 PRC-barrel domain; Region: PRC; pfam05239 685038008037 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 685038008038 signal recognition particle protein; Provisional; Region: PRK10867 685038008039 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 685038008040 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 685038008041 P loop; other site 685038008042 GTP binding site [chemical binding]; other site 685038008043 Signal peptide binding domain; Region: SRP_SPB; pfam02978 685038008044 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 685038008045 hypothetical protein; Provisional; Region: PRK11573 685038008046 Domain of unknown function DUF21; Region: DUF21; pfam01595 685038008047 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 685038008048 Transporter associated domain; Region: CorC_HlyC; smart01091 685038008049 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; cl19511 685038008050 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 685038008051 dimer interface [polypeptide binding]; other site 685038008052 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 685038008053 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 685038008054 recombination and repair protein; Provisional; Region: PRK10869 685038008055 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 685038008056 Walker A/P-loop; other site 685038008057 ATP binding site [chemical binding]; other site 685038008058 Q-loop/lid; other site 685038008059 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 685038008060 Q-loop/lid; other site 685038008061 ABC transporter signature motif; other site 685038008062 Walker B; other site 685038008063 D-loop; other site 685038008064 H-loop/switch region; other site 685038008065 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 685038008066 hypothetical protein; Validated; Region: PRK01777 685038008067 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 685038008068 putative coenzyme Q binding site [chemical binding]; other site 685038008069 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 685038008070 SmpB-tmRNA interface; other site 685038008071 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 685038008072 substrate binding pocket [chemical binding]; other site 685038008073 active site 685038008074 iron coordination sites [ion binding]; other site 685038008075 hydroxyglutarate oxidase; Provisional; Region: PRK11728 685038008076 Predicted dehydrogenase [General function prediction only]; Region: COG0579 685038008077 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 685038008078 tetramerization interface [polypeptide binding]; other site 685038008079 NAD(P) binding site [chemical binding]; other site 685038008080 catalytic residues [active] 685038008081 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 685038008082 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 685038008083 inhibitor-cofactor binding pocket; inhibition site 685038008084 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685038008085 catalytic residue [active] 685038008086 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 685038008087 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 685038008088 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 685038008089 helix_turn_helix gluconate operon transcriptional repressor; Region: HTH_GNTR; smart00345 685038008090 DNA-binding site [nucleotide binding]; DNA binding site 685038008091 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 685038008092 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 685038008093 bacterial OsmY and nodulation domain; Region: BON; smart00749 685038008094 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 685038008095 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 685038008096 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 685038008097 dimerization interface [polypeptide binding]; other site 685038008098 putative DNA binding site [nucleotide binding]; other site 685038008099 Transcriptional regulators [Transcription]; Region: MarR; COG1846 685038008100 putative Zn2+ binding site [ion binding]; other site 685038008101 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YgaP, and similar uncharacterized putative rhodanese-related sulfurtransferases; Region: RHOD_YgaP; cd01527 685038008102 active site residue [active] 685038008103 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 685038008104 Domain in histone-like proteins of HNS family; Region: HNS; cl19571 685038008105 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 685038008106 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 685038008107 hypothetical protein; Provisional; Region: PRK10556 685038008108 hypothetical protein; Provisional; Region: PRK10132 685038008109 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 685038008110 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 685038008111 DNA-binding site [nucleotide binding]; DNA binding site 685038008112 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 685038008113 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685038008114 homodimer interface [polypeptide binding]; other site 685038008115 catalytic residue [active] 685038008116 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 685038008117 Uncharacterized conserved protein [Function unknown]; Region: COG2128 685038008118 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 685038008119 catalytic residues [active] 685038008120 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 685038008121 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 685038008122 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 685038008123 Class I ribonucleotide reductase; Region: RNR_I; cd01679 685038008124 active site 685038008125 dimer interface [polypeptide binding]; other site 685038008126 catalytic residues [active] 685038008127 effector binding site; other site 685038008128 R2 peptide binding site; other site 685038008129 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 685038008130 dimer interface [polypeptide binding]; other site 685038008131 putative radical transfer pathway; other site 685038008132 diiron center [ion binding]; other site 685038008133 tyrosyl radical; other site 685038008134 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 685038008135 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 685038008136 Walker A/P-loop; other site 685038008137 ATP binding site [chemical binding]; other site 685038008138 Q-loop/lid; other site 685038008139 ABC transporter signature motif; other site 685038008140 Walker B; other site 685038008141 D-loop; other site 685038008142 H-loop/switch region; other site 685038008143 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 685038008144 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 685038008145 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685038008146 dimer interface [polypeptide binding]; other site 685038008147 conserved gate region; other site 685038008148 putative PBP binding loops; other site 685038008149 ABC-ATPase subunit interface; other site 685038008150 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 685038008151 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 685038008152 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038008153 putative substrate translocation pore; other site 685038008154 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 685038008155 putative L-valine exporter; Provisional; Region: PRK10408 685038008156 transcriptional repressor MprA; Provisional; Region: PRK10870 685038008157 Transcriptional regulators [Transcription]; Region: MarR; COG1846 685038008158 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 685038008159 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 685038008160 HlyD family secretion protein; Region: HlyD_3; pfam13437 685038008161 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 685038008162 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038008163 putative substrate translocation pore; other site 685038008164 S-ribosylhomocysteinase; Provisional; Region: PRK02260 685038008165 glutamate--cysteine ligase; Provisional; Region: PRK02107 685038008166 Predicted membrane protein [Function unknown]; Region: COG1238 685038008167 potential frameshift: common BLAST hit: gi|260869368|ref|YP_003235770.1| putative hydrolase 685038008168 carbon storage regulator; Provisional; Region: PRK01712 685038008169 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 685038008170 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 685038008171 motif 1; other site 685038008172 active site 685038008173 motif 2; other site 685038008174 motif 3; other site 685038008175 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 685038008176 DHHA1 domain; Region: DHHA1; pfam02272 685038008177 recombination regulator RecX; Reviewed; Region: recX; PRK00117 685038008178 recombinase A; Provisional; Region: recA; PRK09354 685038008179 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 685038008180 hexamer interface [polypeptide binding]; other site 685038008181 Walker A motif; other site 685038008182 ATP binding site [chemical binding]; other site 685038008183 Walker B motif; other site 685038008184 hypothetical protein; Validated; Region: PRK03661 685038008185 murein hydrolase B; Provisional; Region: PRK10760 685038008186 lytic murein transglycosylase B; Region: MltB; TIGR02282 685038008187 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 685038008188 N-acetyl-D-glucosamine binding site [chemical binding]; other site 685038008189 PTS system, glucitol/sorbitol-specific, IIC component; Region: EII-GUT; TIGR00821 685038008190 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 685038008191 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 685038008192 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 685038008193 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 685038008194 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 685038008195 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 685038008196 putative NAD(P) binding site [chemical binding]; other site 685038008197 active site 685038008198 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 685038008199 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 685038008200 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 685038008201 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 685038008202 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 685038008203 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 685038008204 putative active site [active] 685038008205 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 685038008206 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 685038008207 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 685038008208 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685038008209 Walker A motif; other site 685038008210 ATP binding site [chemical binding]; other site 685038008211 Walker B motif; other site 685038008212 arginine finger; other site 685038008213 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 685038008214 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 685038008215 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 685038008216 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 685038008217 iron binding site [ion binding]; other site 685038008218 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 685038008219 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 685038008220 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 685038008221 Acylphosphatase; Region: Acylphosphatase; pfam00708 685038008222 [NiFe] hydrogenase maturation protein HypF; Region: hypF; TIGR00143 685038008223 HypF finger; Region: zf-HYPF; pfam07503 685038008224 HypF finger; Region: zf-HYPF; pfam07503 685038008225 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 685038008226 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 685038008227 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 685038008228 Transcriptional regulators [Transcription]; Region: PurR; COG1609 685038008229 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 685038008230 DNA binding site [nucleotide binding] 685038008231 domain linker motif; other site 685038008232 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 685038008233 dimerization interface (closed form) [polypeptide binding]; other site 685038008234 ligand binding site [chemical binding]; other site 685038008235 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 685038008236 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 685038008237 active site turn [active] 685038008238 phosphorylation site [posttranslational modification] 685038008239 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 685038008240 cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852 685038008241 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 685038008242 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 685038008243 nickel binding site [ion binding]; other site 685038008244 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 685038008245 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 685038008246 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 685038008247 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 685038008248 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 685038008249 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 685038008250 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 685038008251 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 685038008252 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 685038008253 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 685038008254 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 685038008255 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 685038008256 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 685038008257 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 685038008258 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 685038008259 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 685038008260 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 685038008261 hydrogenase assembly chaperone; Provisional; Region: PRK10409 685038008262 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 685038008263 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 685038008264 dimerization interface [polypeptide binding]; other site 685038008265 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 685038008266 ATP binding site [chemical binding]; other site 685038008267 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 685038008268 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 685038008269 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 685038008270 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685038008271 Walker A motif; other site 685038008272 ATP binding site [chemical binding]; other site 685038008273 Walker B motif; other site 685038008274 arginine finger; other site 685038008275 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 685038008276 TOBE domain; Region: TOBE; cl01440 685038008277 TOBE domain; Region: TOBE; cl01440 685038008278 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 685038008279 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 685038008280 MutS domain I; Region: MutS_I; pfam01624 685038008281 MutS domain II; Region: MutS_II; pfam05188 685038008282 MutS domain III; Region: MutS_III; pfam05192 685038008283 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 685038008284 Walker A/P-loop; other site 685038008285 ATP binding site [chemical binding]; other site 685038008286 Q-loop/lid; other site 685038008287 ABC transporter signature motif; other site 685038008288 Walker B; other site 685038008289 D-loop; other site 685038008290 H-loop/switch region; other site 685038008291 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 685038008292 active site 685038008293 metal binding site [ion binding]; metal-binding site 685038008294 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 685038008295 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 685038008296 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 685038008297 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 685038008298 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 685038008299 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 685038008300 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 685038008301 putative aldolase; Validated; Region: PRK08130 685038008302 intersubunit interface [polypeptide binding]; other site 685038008303 active site 685038008304 Zn2+ binding site [ion binding]; other site 685038008305 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 685038008306 hypothetical protein; Provisional; Region: PRK09989 685038008307 putative transporter; Provisional; Region: PRK09821 685038008308 GntP family permease; Region: GntP_permease; pfam02447 685038008309 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 685038008310 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 685038008311 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 685038008312 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 685038008313 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 685038008314 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 685038008315 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 685038008316 DNA binding residues [nucleotide binding] 685038008317 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 685038008318 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 685038008319 Peptidase family M23; Region: Peptidase_M23; pfam01551 685038008320 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685038008321 S-adenosylmethionine binding site [chemical binding]; other site 685038008322 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 685038008323 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 685038008324 Permutation of conserved domain; other site 685038008325 active site 685038008326 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 685038008327 homotrimer interaction site [polypeptide binding]; other site 685038008328 zinc binding site [ion binding]; other site 685038008329 CDP-binding sites; other site 685038008330 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 685038008331 substrate binding site; other site 685038008332 dimer interface; other site 685038008333 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 685038008334 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 685038008335 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 685038008336 ligand-binding site [chemical binding]; other site 685038008337 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 685038008338 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 685038008339 CysD dimerization site [polypeptide binding]; other site 685038008340 G1 box; other site 685038008341 putative GEF interaction site [polypeptide binding]; other site 685038008342 GTP/Mg2+ binding site [chemical binding]; other site 685038008343 Switch I region; other site 685038008344 G2 box; other site 685038008345 G3 box; other site 685038008346 Switch II region; other site 685038008347 G4 box; other site 685038008348 G5 box; other site 685038008349 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 685038008350 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 685038008351 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 685038008352 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 685038008353 Active Sites [active] 685038008354 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 685038008355 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 685038008356 metal binding site [ion binding]; metal-binding site 685038008357 Hok/gef family; Region: HOK_GEF; pfam01848 685038008358 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 685038008359 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 685038008360 Active Sites [active] 685038008361 sulfite reductase subunit beta; Provisional; Region: PRK13504 685038008362 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 685038008363 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 685038008364 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 685038008365 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 685038008366 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 685038008367 Flavodoxin; Region: Flavodoxin_1; pfam00258 685038008368 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 685038008369 FAD binding pocket [chemical binding]; other site 685038008370 FAD binding motif [chemical binding]; other site 685038008371 catalytic residues [active] 685038008372 NAD binding pocket [chemical binding]; other site 685038008373 phosphate binding motif [ion binding]; other site 685038008374 beta-alpha-beta structure motif; other site 685038008375 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 685038008376 active site 685038008377 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 685038008378 putative oxidoreductase FixC; Provisional; Region: PRK10157 685038008379 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 685038008380 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 685038008381 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 685038008382 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 685038008383 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 685038008384 Electron transfer flavoprotein, beta subunit [Energy production and conversion]; Region: FixA; COG2086 685038008385 Ligand Binding Site [chemical binding]; other site 685038008386 benzoate transport; Region: 2A0115; TIGR00895 685038008387 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038008388 putative substrate translocation pore; other site 685038008389 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 685038008390 FAD binding domain; Region: FAD_binding_4; pfam01565 685038008391 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 685038008392 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 685038008393 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 685038008394 NADP binding site [chemical binding]; other site 685038008395 homodimer interface [polypeptide binding]; other site 685038008396 active site 685038008397 Major Facilitator Superfamily; Region: MFS_1; pfam07690 685038008398 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038008399 putative substrate translocation pore; other site 685038008400 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 685038008401 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 685038008402 nucleotide binding site [chemical binding]; other site 685038008403 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 685038008404 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 685038008405 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 685038008406 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 685038008407 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 685038008408 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 685038008409 enolase; Provisional; Region: eno; PRK00077 685038008410 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 685038008411 dimer interface [polypeptide binding]; other site 685038008412 metal binding site [ion binding]; metal-binding site 685038008413 substrate binding pocket [chemical binding]; other site 685038008414 CTP synthetase; Validated; Region: pyrG; PRK05380 685038008415 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 685038008416 Catalytic site [active] 685038008417 active site 685038008418 UTP binding site [chemical binding]; other site 685038008419 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 685038008420 active site 685038008421 putative oxyanion hole; other site 685038008422 catalytic triad [active] 685038008423 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 685038008424 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 685038008425 homodimer interface [polypeptide binding]; other site 685038008426 metal binding site [ion binding]; metal-binding site 685038008427 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 685038008428 homodimer interface [polypeptide binding]; other site 685038008429 active site 685038008430 putative chemical substrate binding site [chemical binding]; other site 685038008431 metal binding site [ion binding]; metal-binding site 685038008432 toxin MazF; Provisional; Region: PRK09907 685038008433 antitoxin MazE; Provisional; Region: PRK09798 685038008434 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 685038008435 HD domain; Region: HD_4; pfam13328 685038008436 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 685038008437 synthetase active site [active] 685038008438 NTP binding site [chemical binding]; other site 685038008439 metal binding site [ion binding]; metal-binding site 685038008440 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 685038008441 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 685038008442 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 685038008443 TRAM domain; Region: TRAM; pfam01938 685038008444 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685038008445 S-adenosylmethionine binding site [chemical binding]; other site 685038008446 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 685038008447 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 685038008448 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 685038008449 dimerization interface [polypeptide binding]; other site 685038008450 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 685038008451 dimer interface [polypeptide binding]; other site 685038008452 phosphorylation site [posttranslational modification] 685038008453 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685038008454 ATP binding site [chemical binding]; other site 685038008455 Mg2+ binding site [ion binding]; other site 685038008456 G-X-G motif; other site 685038008457 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 685038008458 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685038008459 active site 685038008460 phosphorylation site [posttranslational modification] 685038008461 intermolecular recognition site; other site 685038008462 dimerization interface [polypeptide binding]; other site 685038008463 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 685038008464 putative binding surface; other site 685038008465 active site 685038008466 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 685038008467 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 685038008468 active site 685038008469 tetramer interface [polypeptide binding]; other site 685038008470 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 685038008471 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 685038008472 active site 685038008473 tetramer interface [polypeptide binding]; other site 685038008474 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038008475 D-galactonate transporter; Region: 2A0114; TIGR00893 685038008476 putative substrate translocation pore; other site 685038008477 flavodoxin; Provisional; Region: PRK08105 685038008478 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 685038008479 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 685038008480 probable active site [active] 685038008481 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 685038008482 SecY interacting protein Syd; Provisional; Region: PRK04968 685038008483 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 685038008484 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 685038008485 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 685038008486 Domain of unknown function (DUF4478); Region: DUF4478; pfam14793 685038008487 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 685038008488 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 685038008489 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 685038008490 serine transporter; Region: stp; TIGR00814 685038008491 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 685038008492 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 685038008493 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 685038008494 flap endonuclease-like protein; Provisional; Region: PRK09482 685038008495 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 685038008496 active site 685038008497 metal binding site 1 [ion binding]; metal-binding site 685038008498 putative 5' ssDNA interaction site; other site 685038008499 metal binding site 3; metal-binding site 685038008500 metal binding site 2 [ion binding]; metal-binding site 685038008501 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 685038008502 putative DNA binding site [nucleotide binding]; other site 685038008503 putative metal binding site [ion binding]; other site 685038008504 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 685038008505 dimer interface [polypeptide binding]; other site 685038008506 active site 685038008507 metal binding site [ion binding]; metal-binding site 685038008508 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 685038008509 intersubunit interface [polypeptide binding]; other site 685038008510 active site 685038008511 Zn2+ binding site [ion binding]; other site 685038008512 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 685038008513 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038008514 putative substrate translocation pore; other site 685038008515 L-fucose isomerase; Provisional; Region: fucI; PRK10991 685038008516 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 685038008517 hexamer (dimer of trimers) interface [polypeptide binding]; other site 685038008518 trimer interface [polypeptide binding]; other site 685038008519 substrate binding site [chemical binding]; other site 685038008520 Mn binding site [ion binding]; other site 685038008521 L-fuculokinase; Provisional; Region: PRK10331 685038008522 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 685038008523 nucleotide binding site [chemical binding]; other site 685038008524 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 685038008525 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 685038008526 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 685038008527 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 685038008528 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 685038008529 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 685038008530 hypothetical protein; Provisional; Region: PRK10873 685038008531 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 685038008532 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685038008533 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 685038008534 dimerization interface [polypeptide binding]; other site 685038008535 substrate binding pocket [chemical binding]; other site 685038008536 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 685038008537 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 685038008538 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 685038008539 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 685038008540 catalytic residue [active] 685038008541 CsdA-binding activator; Provisional; Region: PRK15019 685038008542 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 685038008543 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 685038008544 putative ATP binding site [chemical binding]; other site 685038008545 putative substrate interface [chemical binding]; other site 685038008546 murein transglycosylase A; Provisional; Region: mltA; PRK11162 685038008547 MltA specific insert domain; Region: MltA; smart00925 685038008548 3D domain; Region: 3D; pfam06725 685038008549 Protein of unknown function (DUF770); Region: DUF770; pfam05591 685038008550 Protein of unknown function (DUF877); Region: DUF877; cl05484 685038008551 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 685038008552 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 685038008553 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 685038008554 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 685038008555 ligand binding site [chemical binding]; other site 685038008556 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 685038008557 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 685038008558 Clp amino terminal domain; Region: Clp_N; pfam02861 685038008559 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685038008560 Walker A motif; other site 685038008561 ATP binding site [chemical binding]; other site 685038008562 Walker B motif; other site 685038008563 arginine finger; other site 685038008564 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685038008565 Walker A motif; other site 685038008566 ATP binding site [chemical binding]; other site 685038008567 Walker B motif; other site 685038008568 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 685038008569 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 685038008570 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 685038008571 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 685038008572 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 685038008573 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 685038008574 PAAR motif; Region: PAAR_motif; pfam05488 685038008575 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 685038008576 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 685038008577 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 685038008578 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 685038008579 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 685038008580 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 685038008581 PAAR motif; Region: PAAR_motif; pfam05488 685038008582 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 685038008583 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 685038008584 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 685038008585 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 685038008586 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 685038008587 ImpA domain protein; Region: DUF3702; pfam12486 685038008588 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 685038008589 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 685038008590 putative ligand binding site [chemical binding]; other site 685038008591 putative NAD binding site [chemical binding]; other site 685038008592 catalytic site [active] 685038008593 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 685038008594 putative active site [active] 685038008595 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 685038008596 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 685038008597 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685038008598 homodimer interface [polypeptide binding]; other site 685038008599 catalytic residue [active] 685038008600 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 685038008601 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 685038008602 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 685038008603 active site turn [active] 685038008604 phosphorylation site [posttranslational modification] 685038008605 CAT RNA binding domain; Region: CAT_RBD; pfam03123 685038008606 PRD domain; Region: PRD; pfam00874 685038008607 PRD domain; Region: PRD; pfam00874 685038008608 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 685038008609 AMIN domain; Region: AMIN; pfam11741 685038008610 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 685038008611 active site 685038008612 metal binding site [ion binding]; metal-binding site 685038008613 N-acetylglutamate synthase; Validated; Region: PRK05279 685038008614 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 685038008615 putative feedback inhibition sensing region; other site 685038008616 putative nucleotide binding site [chemical binding]; other site 685038008617 putative substrate binding site [chemical binding]; other site 685038008618 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 685038008619 Coenzyme A binding pocket [chemical binding]; other site 685038008620 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 685038008621 AAA domain; Region: AAA_30; pfam13604 685038008622 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 685038008623 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 685038008624 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 685038008625 protease3; Provisional; Region: PRK15101 685038008626 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 685038008627 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 685038008628 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 685038008629 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 685038008630 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 685038008631 hypothetical protein; Provisional; Region: PRK10332 685038008632 hypothetical protein; Provisional; Region: PRK11521 685038008633 hypothetical protein; Provisional; Region: PRK10557 685038008634 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 685038008635 hypothetical protein; Provisional; Region: PRK10506 685038008636 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 685038008637 Bacterial shufflon protein, N-terminal constant region; Region: Shufflon_N; pfam04917 685038008638 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 685038008639 dimerization interface [polypeptide binding]; other site 685038008640 active site 685038008641 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 685038008642 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 685038008643 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 685038008644 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 685038008645 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 685038008646 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 685038008647 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 685038008648 putative active site [active] 685038008649 Ap4A binding site [chemical binding]; other site 685038008650 nudix motif; other site 685038008651 putative metal binding site [ion binding]; other site 685038008652 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 685038008653 putative DNA-binding cleft [nucleotide binding]; other site 685038008654 putative DNA clevage site; other site 685038008655 molecular lever; other site 685038008656 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 685038008657 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 685038008658 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 685038008659 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 685038008660 active site 685038008661 catalytic tetrad [active] 685038008662 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038008663 putative substrate translocation pore; other site 685038008664 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 685038008665 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 685038008666 putative acyl-acceptor binding pocket; other site 685038008667 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 685038008668 acyl-activating enzyme (AAE) consensus motif; other site 685038008669 putative AMP binding site [chemical binding]; other site 685038008670 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 685038008671 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 685038008672 DNA binding site [nucleotide binding] 685038008673 domain linker motif; other site 685038008674 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 685038008675 dimerization interface (closed form) [polypeptide binding]; other site 685038008676 ligand binding site [chemical binding]; other site 685038008677 diaminopimelate decarboxylase; Provisional; Region: PRK11165 685038008678 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 685038008679 active site 685038008680 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 685038008681 substrate binding site [chemical binding]; other site 685038008682 catalytic residues [active] 685038008683 dimer interface [polypeptide binding]; other site 685038008684 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 685038008685 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685038008686 The C-terminal substrate binding domain of LysR, transcriptional regulator for lysine biosynthesis, contains the type 2 periplasmic binding fold; Region: PBP2_LysR; cd08456 685038008687 putative dimerization interface [polypeptide binding]; other site 685038008688 putative racemase; Provisional; Region: PRK10200 685038008689 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 685038008690 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038008691 putative substrate translocation pore; other site 685038008692 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 685038008693 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 685038008694 NADP binding site [chemical binding]; other site 685038008695 homodimer interface [polypeptide binding]; other site 685038008696 active site 685038008697 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 685038008698 putative acyltransferase; Provisional; Region: PRK05790 685038008699 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 685038008700 dimer interface [polypeptide binding]; other site 685038008701 active site 685038008702 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 685038008703 serine transporter; Region: stp; TIGR00814 685038008704 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 685038008705 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 685038008706 Peptidase family M23; Region: Peptidase_M23; pfam01551 685038008707 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 685038008708 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 685038008709 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 685038008710 xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971 685038008711 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 685038008712 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 685038008713 xanthine dehydrogenase subunit XdhC; Provisional; Region: PRK09908 685038008714 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 685038008715 catalytic loop [active] 685038008716 iron binding site [ion binding]; other site 685038008717 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 685038008718 GAF domain; Region: GAF; cl17456 685038008719 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 685038008720 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 685038008721 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685038008722 Walker A motif; other site 685038008723 ATP binding site [chemical binding]; other site 685038008724 Walker B motif; other site 685038008725 arginine finger; other site 685038008726 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 685038008727 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 685038008728 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 685038008729 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 685038008730 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 685038008731 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 685038008732 catalytic residue [active] 685038008733 peptidase; Reviewed; Region: PRK13004 685038008734 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 685038008735 putative metal binding site [ion binding]; other site 685038008736 putative dimer interface [polypeptide binding]; other site 685038008737 D-hydantoinase; Region: D-hydantoinase; TIGR02033 685038008738 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 685038008739 tetramer interface [polypeptide binding]; other site 685038008740 active site 685038008741 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 685038008742 putative substrate binding site [chemical binding]; other site 685038008743 nucleotide binding site [chemical binding]; other site 685038008744 nucleotide binding site [chemical binding]; other site 685038008745 homodimer interface [polypeptide binding]; other site 685038008746 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 685038008747 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 685038008748 XdhC Rossmann domain; Region: XdhC_C; pfam13478 685038008749 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 685038008750 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 685038008751 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 685038008752 Ligand binding site; other site 685038008753 metal-binding site 685038008754 putative selenate reductase subunit YgfK; Provisional; Region: PRK09853 685038008755 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 685038008756 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 685038008757 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 685038008758 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 685038008759 putative selenium metabolism protein SsnA; Region: Se_ssnA; TIGR03314 685038008760 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 685038008761 active site 685038008762 putative substrate binding pocket [chemical binding]; other site 685038008763 FAD binding domain; Region: FAD_binding_4; cl19922 685038008764 probable selenate reductase, FAD-binding subunit; Region: Se_sel_red_FAD; TIGR03312 685038008765 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 685038008766 probable selenate reductase, molybdenum-binding subunit; Region: Se_sel_red_Mo; TIGR03313 685038008767 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 685038008768 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 685038008769 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 685038008770 uracil-xanthine permease; Region: ncs2; TIGR00801 685038008771 Sulfate transporter family; Region: Sulfate_transp; cl19250 685038008772 guanine deaminase; Provisional; Region: PRK09228 685038008773 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 685038008774 active site 685038008775 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 685038008776 Sulfate transporter family; Region: Sulfate_transp; cl19250 685038008777 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 685038008778 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 685038008779 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12809 685038008780 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 685038008781 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 685038008782 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 685038008783 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 685038008784 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 685038008785 Sulfate transporter family; Region: Sulfate_transp; cl19250 685038008786 xanthine permease; Region: pbuX; TIGR03173 685038008787 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 685038008788 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 685038008789 active site 685038008790 metal binding site [ion binding]; metal-binding site 685038008791 nudix motif; other site 685038008792 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 685038008793 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 685038008794 dimer interface [polypeptide binding]; other site 685038008795 putative anticodon binding site; other site 685038008796 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 685038008797 motif 1; other site 685038008798 active site 685038008799 motif 2; other site 685038008800 motif 3; other site 685038008801 peptide chain release factor 2; Validated; Region: prfB; PRK00578 685038008802 This domain is found in peptide chain release factors; Region: PCRF; smart00937 685038008803 RF-1 domain; Region: RF-1; pfam00472 685038008804 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 685038008805 DHH family; Region: DHH; pfam01368 685038008806 DHHA1 domain; Region: DHHA1; pfam02272 685038008807 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 685038008808 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 685038008809 dimerization domain [polypeptide binding]; other site 685038008810 dimer interface [polypeptide binding]; other site 685038008811 catalytic residues [active] 685038008812 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 685038008813 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 685038008814 active site 685038008815 Int/Topo IB signature motif; other site 685038008816 flavodoxin FldB; Provisional; Region: PRK12359 685038008817 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 685038008818 hypothetical protein; Provisional; Region: PRK10878 685038008819 putative global regulator; Reviewed; Region: PRK09559 685038008820 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 685038008821 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 685038008822 hemolysin; Provisional; Region: PRK15087 685038008823 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 685038008824 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 685038008825 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 685038008826 glycine dehydrogenase; Provisional; Region: PRK05367 685038008827 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 685038008828 tetramer interface [polypeptide binding]; other site 685038008829 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685038008830 catalytic residue [active] 685038008831 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 685038008832 tetramer interface [polypeptide binding]; other site 685038008833 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685038008834 catalytic residue [active] 685038008835 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 685038008836 lipoyl attachment site [posttranslational modification]; other site 685038008837 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 685038008838 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 685038008839 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 685038008840 oxidoreductase; Provisional; Region: PRK08013 685038008841 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 685038008842 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 685038008843 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 685038008844 proline aminopeptidase P II; Provisional; Region: PRK10879 685038008845 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 685038008846 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 685038008847 active site 685038008848 hypothetical protein; Reviewed; Region: PRK01736 685038008849 Z-ring-associated protein; Provisional; Region: PRK10972 685038008850 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 685038008851 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 685038008852 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 685038008853 ligand binding site [chemical binding]; other site 685038008854 NAD binding site [chemical binding]; other site 685038008855 tetramer interface [polypeptide binding]; other site 685038008856 catalytic site [active] 685038008857 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 685038008858 L-serine binding site [chemical binding]; other site 685038008859 ACT domain interface; other site 685038008860 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 685038008861 tetramer (dimer of dimers) interface [polypeptide binding]; other site 685038008862 active site 685038008863 dimer interface [polypeptide binding]; other site 685038008864 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 685038008865 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 685038008866 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685038008867 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 685038008868 putative dimerization interface [polypeptide binding]; other site 685038008869 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 685038008870 Transcriptional regulator [Transcription]; Region: LysR; COG0583 685038008871 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685038008872 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 685038008873 dimerization interface [polypeptide binding]; other site 685038008874 oxidative stress defense protein; Provisional; Region: PRK11087 685038008875 arginine exporter protein; Provisional; Region: PRK09304 685038008876 mechanosensitive channel MscS; Provisional; Region: PRK10334 685038008877 Conserved TM helix; Region: TM_helix; pfam05552 685038008878 Mechanosensitive ion channel; Region: MS_channel; pfam00924 685038008879 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 685038008880 active site 685038008881 intersubunit interface [polypeptide binding]; other site 685038008882 zinc binding site [ion binding]; other site 685038008883 Na+ binding site [ion binding]; other site 685038008884 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 685038008885 substrate binding site [chemical binding]; other site 685038008886 hinge regions; other site 685038008887 ADP binding site [chemical binding]; other site 685038008888 catalytic site [active] 685038008889 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 685038008890 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 685038008891 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 685038008892 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 685038008893 trimer interface [polypeptide binding]; other site 685038008894 putative Zn binding site [ion binding]; other site 685038008895 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 685038008896 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 685038008897 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 685038008898 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 685038008899 Walker A/P-loop; other site 685038008900 ATP binding site [chemical binding]; other site 685038008901 Q-loop/lid; other site 685038008902 ABC transporter signature motif; other site 685038008903 Walker B; other site 685038008904 D-loop; other site 685038008905 H-loop/switch region; other site 685038008906 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 685038008907 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 685038008908 Walker A/P-loop; other site 685038008909 ATP binding site [chemical binding]; other site 685038008910 Q-loop/lid; other site 685038008911 ABC transporter signature motif; other site 685038008912 Walker B; other site 685038008913 D-loop; other site 685038008914 H-loop/switch region; other site 685038008915 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 685038008916 active site 685038008917 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10022 685038008918 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 685038008919 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 685038008920 putative NAD(P) binding site [chemical binding]; other site 685038008921 catalytic Zn binding site [ion binding]; other site 685038008922 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 685038008923 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 685038008924 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 685038008925 active site 685038008926 P-loop; other site 685038008927 phosphorylation site [posttranslational modification] 685038008928 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 685038008929 active site 685038008930 phosphorylation site [posttranslational modification] 685038008931 prohibitin homologues; Region: PHB; smart00244 685038008932 Prohibitin family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_prohibitin; cd03401 685038008933 transketolase; Reviewed; Region: PRK12753 685038008934 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 685038008935 TPP-binding site [chemical binding]; other site 685038008936 dimer interface [polypeptide binding]; other site 685038008937 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 685038008938 PYR/PP interface [polypeptide binding]; other site 685038008939 dimer interface [polypeptide binding]; other site 685038008940 TPP binding site [chemical binding]; other site 685038008941 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 685038008942 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 685038008943 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 685038008944 oligomer interface [polypeptide binding]; other site 685038008945 putative active site [active] 685038008946 Mn binding site [ion binding]; other site 685038008947 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 685038008948 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 685038008949 dimer interface [polypeptide binding]; other site 685038008950 active site 685038008951 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 685038008952 catalytic residues [active] 685038008953 substrate binding site [chemical binding]; other site 685038008954 Protein of unknown function (DUF2684); Region: DUF2684; pfam10885 685038008955 S-adenosylmethionine synthetase; Validated; Region: PRK05250 685038008956 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 685038008957 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 685038008958 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 685038008959 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 685038008960 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038008961 putative substrate translocation pore; other site 685038008962 hypothetical protein; Provisional; Region: PRK04860 685038008963 DNA-specific endonuclease I; Provisional; Region: PRK15137 685038008964 RNA methyltransferase, RsmE family; Region: TIGR00046 685038008965 glutathione synthetase; Provisional; Region: PRK05246 685038008966 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 685038008967 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 685038008968 hypothetical protein; Validated; Region: PRK00228 685038008969 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 685038008970 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 685038008971 Walker A motif; other site 685038008972 ATP binding site [chemical binding]; other site 685038008973 Walker B motif; other site 685038008974 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 685038008975 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 685038008976 YGGT family; Region: YGGT; pfam02325 685038008977 Predicted integral membrane protein [Function unknown]; Region: COG0762 685038008978 hypothetical protein; Validated; Region: PRK05090 685038008979 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 685038008980 active site 685038008981 dimerization interface [polypeptide binding]; other site 685038008982 HemN family oxidoreductase; Provisional; Region: PRK05660 685038008983 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 685038008984 FeS/SAM binding site; other site 685038008985 HemN C-terminal domain; Region: HemN_C; pfam06969 685038008986 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 685038008987 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 685038008988 active site 685038008989 homodimer interface [polypeptide binding]; other site 685038008990 hypothetical protein; Provisional; Region: PRK10626 685038008991 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 685038008992 hypothetical protein; Provisional; Region: PRK11702 685038008993 Predicted S-adenosylmethionine-dependent methyltransferase [General function prediction only]; Region: COG0220 685038008994 adenine DNA glycosylase; Provisional; Region: PRK10880 685038008995 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 685038008996 minor groove reading motif; other site 685038008997 helix-hairpin-helix signature motif; other site 685038008998 substrate binding pocket [chemical binding]; other site 685038008999 active site 685038009000 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 685038009001 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 685038009002 DNA binding and oxoG recognition site [nucleotide binding] 685038009003 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2924 685038009004 murein transglycosylase C; Provisional; Region: mltC; PRK11671 685038009005 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 685038009006 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 685038009007 N-acetyl-D-glucosamine binding site [chemical binding]; other site 685038009008 catalytic residue [active] 685038009009 nucleoside transporter; Region: 2A0110; TIGR00889 685038009010 Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825 685038009011 ornithine decarboxylase; Provisional; Region: PRK13578 685038009012 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 685038009013 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 685038009014 homodimer interface [polypeptide binding]; other site 685038009015 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685038009016 catalytic residue [active] 685038009017 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 685038009018 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 685038009019 KpsF/GutQ family protein; Region: kpsF; TIGR00393 685038009020 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 685038009021 putative active site [active] 685038009022 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 685038009023 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 685038009024 Chain length determinant protein; Region: Wzz; cl19730 685038009025 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 685038009026 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 685038009027 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 685038009028 Ligand binding site; other site 685038009029 oligomer interface; other site 685038009030 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 685038009031 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 685038009032 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 685038009033 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 685038009034 Transposase, Mutator family; Region: Transposase_mut; cl19537 685038009035 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 685038009036 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 685038009037 Tetratricopeptide repeat; Region: TPR_19; pfam14559 685038009038 TPR motif; other site 685038009039 TPR repeat; Region: TPR_11; pfam13414 685038009040 binding surface 685038009041 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; cl19502 685038009042 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 685038009043 active site 685038009044 nucleotide binding site [chemical binding]; other site 685038009045 HIGH motif; other site 685038009046 KMSKS motif; other site 685038009047 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 685038009048 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 685038009049 Walker A/P-loop; other site 685038009050 ATP binding site [chemical binding]; other site 685038009051 Q-loop/lid; other site 685038009052 ABC transporter signature motif; other site 685038009053 Walker B; other site 685038009054 D-loop; other site 685038009055 H-loop/switch region; other site 685038009056 ABC-2 type transporter; Region: ABC2_membrane; cl17235 685038009057 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 685038009058 putative general secretion pathway protein YghD; Provisional; Region: PRK09731 685038009059 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 685038009060 GspL-like protein; Provisional; Region: PRK09662 685038009061 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 685038009062 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl19066 685038009063 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 685038009064 type II secretion system protein J; Region: gspJ; TIGR01711 685038009065 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 685038009066 type II secretion system protein I; Region: gspI; TIGR01707 685038009067 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 685038009068 Prokaryotic N-terminal methylation motif; Region: N_methyl; pfam07963 685038009069 Type II transport protein GspH; Region: GspH; pfam12019 685038009070 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 685038009071 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 685038009072 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 685038009073 type II secretion system protein F; Region: GspF; TIGR02120 685038009074 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 685038009075 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 685038009076 type II secretion system protein E; Region: type_II_gspE; TIGR02533 685038009077 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 685038009078 Walker A motif; other site 685038009079 ATP binding site [chemical binding]; other site 685038009080 Walker B motif; other site 685038009081 type II secretion system protein D; Region: type_II_gspD; TIGR02517 685038009082 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 685038009083 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 685038009084 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 685038009085 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 685038009086 putative type II secretion protein GspC; Provisional; Region: PRK09681 685038009087 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 685038009088 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 685038009089 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 685038009090 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 685038009091 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 685038009092 Domain of unknown function (DUF4092); Region: DUF4092; pfam13322 685038009093 Peptidase M60-like family; Region: M60-like; pfam13402 685038009094 glycolate transporter; Provisional; Region: PRK09695 685038009095 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 685038009096 active site 685038009097 hypothetical protein; Provisional; Region: PRK09732 685038009098 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 685038009099 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 685038009100 Cysteine-rich domain; Region: CCG; pfam02754 685038009101 Cysteine-rich domain; Region: CCG; pfam02754 685038009102 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 685038009103 FAD binding domain; Region: FAD_binding_4; pfam01565 685038009104 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 685038009105 FAD binding domain; Region: FAD_binding_4; pfam01565 685038009106 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 685038009107 DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990 685038009108 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 685038009109 DNA-binding site [nucleotide binding]; DNA binding site 685038009110 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 685038009111 acyl-CoA synthetase; Validated; Region: PRK09192 685038009112 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 685038009113 acyl-activating enzyme (AAE) consensus motif; other site 685038009114 active site 685038009115 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 685038009116 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685038009117 NAD(P) binding site [chemical binding]; other site 685038009118 active site 685038009119 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 685038009120 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 685038009121 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 685038009122 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 685038009123 catalytic residue [active] 685038009124 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 685038009125 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 685038009126 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; pfam09695 685038009127 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 685038009128 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 685038009129 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 685038009130 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 685038009131 active site 685038009132 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 685038009133 TMP-binding site; other site 685038009134 ATP-binding site [chemical binding]; other site 685038009135 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 685038009136 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 685038009137 TMP-binding site; other site 685038009138 ATP-binding site [chemical binding]; other site 685038009139 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 685038009140 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 685038009141 CHAP domain; Region: CHAP; pfam05257 685038009142 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 685038009143 putative S-transferase; Provisional; Region: PRK11752 685038009144 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 685038009145 C-terminal domain interface [polypeptide binding]; other site 685038009146 GSH binding site (G-site) [chemical binding]; other site 685038009147 dimer interface [polypeptide binding]; other site 685038009148 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 685038009149 dimer interface [polypeptide binding]; other site 685038009150 N-terminal domain interface [polypeptide binding]; other site 685038009151 active site 685038009152 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 685038009153 hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380 685038009154 hydrogenase 2-specific chaperone; Provisional; Region: PRK10465 685038009155 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 685038009156 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 685038009157 putative substrate-binding site; other site 685038009158 nickel binding site [ion binding]; other site 685038009159 hydrogenase 2 large subunit; Provisional; Region: PRK10467 685038009160 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 685038009161 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 685038009162 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 685038009163 hydrogenase 2 small subunit; Provisional; Region: PRK10468 685038009164 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 685038009165 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 685038009166 NiFe/NiFeSe hydrogenase small subunit C-terminal; Region: NiFe_hyd_SSU_C; pfam14720 685038009167 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 685038009168 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 685038009169 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 685038009170 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 685038009171 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 685038009172 active site 685038009173 catalytic tetrad [active] 685038009174 hypothetical protein; Provisional; Region: PRK05208 685038009175 oxidoreductase; Provisional; Region: PRK07985 685038009176 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 685038009177 NAD binding site [chemical binding]; other site 685038009178 metal binding site [ion binding]; metal-binding site 685038009179 active site 685038009180 biopolymer transport protein ExbD; Provisional; Region: PRK11267 685038009181 biopolymer transport protein ExbB; Provisional; Region: PRK10414 685038009182 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 685038009183 homodimer interface [polypeptide binding]; other site 685038009184 substrate-cofactor binding pocket; other site 685038009185 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685038009186 catalytic residue [active] 685038009187 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 685038009188 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 685038009189 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 685038009190 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 685038009191 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 685038009192 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 685038009193 dimer interface [polypeptide binding]; other site 685038009194 active site 685038009195 metal binding site [ion binding]; metal-binding site 685038009196 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 685038009197 active site 685038009198 catalytic tetrad [active] 685038009199 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 685038009200 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 685038009201 putative outer membrane lipoprotein; Provisional; Region: PRK09973 685038009202 hypothetical protein; Provisional; Region: PRK01254 685038009203 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 685038009204 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 685038009205 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 685038009206 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 685038009207 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 685038009208 DNA-binding site [nucleotide binding]; DNA binding site 685038009209 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 685038009210 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 685038009211 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 685038009212 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 685038009213 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 685038009214 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 685038009215 putative NAD(P) binding site [chemical binding]; other site 685038009216 catalytic Zn binding site [ion binding]; other site 685038009217 structural Zn binding site [ion binding]; other site 685038009218 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 685038009219 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 685038009220 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 685038009221 DctM-like transporters; Region: DctM; pfam06808 685038009222 TRAP transporter, DctM subunit; Region: dctM; TIGR00786 685038009223 FtsI repressor; Provisional; Region: PRK10883 685038009224 The first Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_1_CueO_FtsP; cd04232 685038009225 Domain 2 interface [polypeptide binding]; other site 685038009226 Domain 3 interface [polypeptide binding]; other site 685038009227 trinuclear Cu binding site [ion binding]; other site 685038009228 The second Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_2_CueO_FtsP; cd13867 685038009229 Domain 1 interface [polypeptide binding]; other site 685038009230 Domain 3 interface [polypeptide binding]; other site 685038009231 The third Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_3_CueO_FtsP; cd13890 685038009232 Domain 2 interface [polypeptide binding]; other site 685038009233 Domain 1 interface [polypeptide binding]; other site 685038009234 Type 1 (T1) Cu binding site [ion binding]; other site 685038009235 trinuclear Cu binding site [ion binding]; other site 685038009236 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 685038009237 putative acyl-acceptor binding pocket; other site 685038009238 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 685038009239 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 685038009240 CAP-like domain; other site 685038009241 active site 685038009242 primary dimer interface [polypeptide binding]; other site 685038009243 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 685038009244 putative ABC transporter periplasmic-binding protein; Provisional; Region: PRK09755 685038009245 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 685038009246 peptide binding site [polypeptide binding]; other site 685038009247 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 685038009248 TIGR00156 family protein; Region: TIGR00156 685038009249 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 685038009250 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685038009251 active site 685038009252 phosphorylation site [posttranslational modification] 685038009253 intermolecular recognition site; other site 685038009254 dimerization interface [polypeptide binding]; other site 685038009255 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 685038009256 DNA binding site [nucleotide binding] 685038009257 sensor protein QseC; Provisional; Region: PRK10337 685038009258 HAMP domain; Region: HAMP; pfam00672 685038009259 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 685038009260 dimer interface [polypeptide binding]; other site 685038009261 phosphorylation site [posttranslational modification] 685038009262 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685038009263 ATP binding site [chemical binding]; other site 685038009264 Mg2+ binding site [ion binding]; other site 685038009265 G-X-G motif; other site 685038009266 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 685038009267 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 685038009268 Uncharacterized conserved protein [Function unknown]; Region: COG1359 685038009269 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 685038009270 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 685038009271 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 685038009272 putative active site [active] 685038009273 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 685038009274 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 685038009275 siderophore binding site; other site 685038009276 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 685038009277 ABC-ATPase subunit interface; other site 685038009278 dimer interface [polypeptide binding]; other site 685038009279 putative PBP binding regions; other site 685038009280 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 685038009281 ABC-ATPase subunit interface; other site 685038009282 dimer interface [polypeptide binding]; other site 685038009283 putative PBP binding regions; other site 685038009284 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 685038009285 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 685038009286 Walker A/P-loop; other site 685038009287 ATP binding site [chemical binding]; other site 685038009288 Q-loop/lid; other site 685038009289 ABC transporter signature motif; other site 685038009290 Walker B; other site 685038009291 D-loop; other site 685038009292 H-loop/switch region; other site 685038009293 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 685038009294 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 685038009295 N-terminal plug; other site 685038009296 ligand-binding site [chemical binding]; other site 685038009297 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 685038009298 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685038009299 ATP binding site [chemical binding]; other site 685038009300 Mg2+ binding site [ion binding]; other site 685038009301 G-X-G motif; other site 685038009302 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 685038009303 anchoring element; other site 685038009304 dimer interface [polypeptide binding]; other site 685038009305 ATP binding site [chemical binding]; other site 685038009306 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 685038009307 active site 685038009308 metal binding site [ion binding]; metal-binding site 685038009309 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 685038009310 esterase YqiA; Provisional; Region: PRK11071 685038009311 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 685038009312 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 685038009313 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 685038009314 active site 685038009315 metal binding site [ion binding]; metal-binding site 685038009316 hexamer interface [polypeptide binding]; other site 685038009317 putative dehydrogenase; Provisional; Region: PRK11039 685038009318 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 685038009319 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 685038009320 dimer interface [polypeptide binding]; other site 685038009321 ADP-ribose binding site [chemical binding]; other site 685038009322 active site 685038009323 nudix motif; other site 685038009324 metal binding site [ion binding]; metal-binding site 685038009325 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 685038009326 Outer membrane efflux protein; Region: OEP; pfam02321 685038009327 Outer membrane efflux protein; Region: OEP; pfam02321 685038009328 hypothetical protein; Provisional; Region: PRK11653 685038009329 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 685038009330 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 685038009331 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 685038009332 catalytic residues [active] 685038009333 hinge region; other site 685038009334 alpha helical domain; other site 685038009335 putative disulfide oxidoreductase; Provisional; Region: PRK04307 685038009336 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 685038009337 putative active site [active] 685038009338 metal binding site [ion binding]; metal-binding site 685038009339 zinc transporter ZupT; Provisional; Region: PRK04201 685038009340 Protein of unknown function (DUF4051); Region: DUF4051; pfam13260 685038009341 putative fimbrial protein; Provisional; Region: PRK09733 685038009342 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 685038009343 PapC N-terminal domain; Region: PapC_N; pfam13954 685038009344 Outer membrane usher protein; Region: Usher; pfam00577 685038009345 PapC C-terminal domain; Region: PapC_C; pfam13953 685038009346 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 685038009347 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 685038009348 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 685038009349 Fimbrial protein; Region: Fimbrial; pfam00419 685038009350 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 685038009351 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 685038009352 glycogen synthesis protein GlgS; Provisional; Region: PRK02922 685038009353 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 685038009354 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 685038009355 Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_flotillin; cd03399 685038009356 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 685038009357 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 685038009358 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 685038009359 putative ribose interaction site [chemical binding]; other site 685038009360 putative ADP binding site [chemical binding]; other site 685038009361 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 685038009362 active site 685038009363 nucleotide binding site [chemical binding]; other site 685038009364 HIGH motif; other site 685038009365 KMSKS motif; other site 685038009366 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 685038009367 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 685038009368 metal binding triad; other site 685038009369 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 685038009370 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 685038009371 metal binding triad; other site 685038009372 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; cl19627 685038009373 Uncharacterized conserved protein [Function unknown]; Region: COG3025 685038009374 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 685038009375 putative active site [active] 685038009376 putative metal binding residues [ion binding]; other site 685038009377 signature motif; other site 685038009378 putative triphosphate binding site [ion binding]; other site 685038009379 CHAD domain; Region: CHAD; pfam05235 685038009380 SH3 domain-containing protein; Provisional; Region: PRK10884 685038009381 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 685038009382 Bacterial SH3 domain homologues; Region: SH3b; smart00287 685038009383 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 685038009384 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 685038009385 active site 685038009386 NTP binding site [chemical binding]; other site 685038009387 metal binding triad [ion binding]; metal-binding site 685038009388 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 685038009389 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 685038009390 Zn2+ binding site [ion binding]; other site 685038009391 Mg2+ binding site [ion binding]; other site 685038009392 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 685038009393 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 685038009394 homooctamer interface [polypeptide binding]; other site 685038009395 active site 685038009396 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 685038009397 transcriptional activator TtdR; Provisional; Region: PRK09801 685038009398 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685038009399 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 685038009400 putative effector binding pocket; other site 685038009401 putative dimerization interface [polypeptide binding]; other site 685038009402 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 685038009403 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 685038009404 Sodium:sulfate symporter transmembrane region; Region: Na_sulph_symp; pfam00939 685038009405 anion transporter; Region: dass; TIGR00785 685038009406 transmembrane helices; other site 685038009407 UGMP family protein; Validated; Region: PRK09604 685038009408 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 685038009409 nucleotide binding site [chemical binding]; other site 685038009410 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 685038009411 DNA primase; Validated; Region: dnaG; PRK05667 685038009412 CHC2 zinc finger; Region: zf-CHC2; pfam01807 685038009413 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 685038009414 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 685038009415 active site 685038009416 metal binding site [ion binding]; metal-binding site 685038009417 interdomain interaction site; other site 685038009418 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 685038009419 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 685038009420 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 685038009421 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 685038009422 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 685038009423 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 685038009424 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 685038009425 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 685038009426 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 685038009427 DNA binding residues [nucleotide binding] 685038009428 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 685038009429 active site 685038009430 SUMO-1 interface [polypeptide binding]; other site 685038009431 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 685038009432 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 685038009433 FAD binding pocket [chemical binding]; other site 685038009434 FAD binding motif [chemical binding]; other site 685038009435 phosphate binding motif [ion binding]; other site 685038009436 NAD binding pocket [chemical binding]; other site 685038009437 Predicted transcriptional regulators [Transcription]; Region: COG1695 685038009438 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 685038009439 PAS fold; Region: PAS_3; pfam08447 685038009440 putative active site [active] 685038009441 heme pocket [chemical binding]; other site 685038009442 HAMP domain; Region: HAMP; pfam00672 685038009443 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 685038009444 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 685038009445 dimer interface [polypeptide binding]; other site 685038009446 putative CheW interface [polypeptide binding]; other site 685038009447 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 685038009448 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 685038009449 inhibitor-cofactor binding pocket; inhibition site 685038009450 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685038009451 catalytic residue [active] 685038009452 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 685038009453 dimer interface [polypeptide binding]; other site 685038009454 putative tRNA-binding site [nucleotide binding]; other site 685038009455 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 685038009456 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 685038009457 DNA binding site [nucleotide binding] 685038009458 domain linker motif; other site 685038009459 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 685038009460 putative dimerization interface [polypeptide binding]; other site 685038009461 putative ligand binding site [chemical binding]; other site 685038009462 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 685038009463 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 685038009464 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 685038009465 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 685038009466 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 685038009467 cryptic beta-D-galactosidase subunit beta; Reviewed; Region: ebgC; PRK10202 685038009468 inner membrane transporter YjeM; Provisional; Region: PRK15238 685038009469 alpha-glucosidase; Provisional; Region: PRK10137 685038009470 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 685038009471 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 685038009472 active site 685038009473 FMN binding site [chemical binding]; other site 685038009474 2,4-decadienoyl-CoA binding site; other site 685038009475 catalytic residue [active] 685038009476 4Fe-4S cluster binding site [ion binding]; other site 685038009477 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 685038009478 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 685038009479 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 685038009480 non-specific DNA binding site [nucleotide binding]; other site 685038009481 salt bridge; other site 685038009482 sequence-specific DNA binding site [nucleotide binding]; other site 685038009483 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 685038009484 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685038009485 S-adenosylmethionine binding site [chemical binding]; other site 685038009486 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 685038009487 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 685038009488 putative active site [active] 685038009489 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 685038009490 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 685038009491 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 685038009492 serine/threonine transporter SstT; Provisional; Region: PRK13628 685038009493 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 685038009494 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 685038009495 galactarate dehydratase; Region: galactar-dH20; TIGR03248 685038009496 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 685038009497 glucuronate isomerase; Reviewed; Region: PRK02925 685038009498 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038009499 D-galactonate transporter; Region: 2A0114; TIGR00893 685038009500 putative substrate translocation pore; other site 685038009501 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 685038009502 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 685038009503 DNA-binding site [nucleotide binding]; DNA binding site 685038009504 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 685038009505 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 685038009506 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 685038009507 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 685038009508 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 685038009509 Predicted membrane protein [Function unknown]; Region: COG5393 685038009510 YqjK-like protein; Region: YqjK; pfam13997 685038009511 Predicted membrane protein [Function unknown]; Region: COG2259 685038009512 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 685038009513 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 685038009514 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 685038009515 putative dimer interface [polypeptide binding]; other site 685038009516 N-terminal domain interface [polypeptide binding]; other site 685038009517 putative substrate binding pocket (H-site) [chemical binding]; other site 685038009518 Predicted membrane protein [Function unknown]; Region: COG3152 685038009519 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685038009520 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 685038009521 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 685038009522 dimerization interface [polypeptide binding]; other site 685038009523 Pirin-related protein [General function prediction only]; Region: COG1741 685038009524 Pirin; Region: Pirin; pfam02678 685038009525 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 685038009526 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 685038009527 serine transporter; Region: stp; TIGR00814 685038009528 L-serine dehydratase TdcG; Provisional; Region: PRK15040 685038009529 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 685038009530 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 685038009531 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 685038009532 homotrimer interaction site [polypeptide binding]; other site 685038009533 putative active site [active] 685038009534 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 685038009535 Pyruvate formate lyase 1; Region: PFL1; cd01678 685038009536 coenzyme A binding site [chemical binding]; other site 685038009537 active site 685038009538 catalytic residues [active] 685038009539 glycine loop; other site 685038009540 propionate/acetate kinase; Provisional; Region: PRK12379 685038009541 threonine/serine transporter TdcC; Provisional; Region: PRK13629 685038009542 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 685038009543 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 685038009544 tetramer interface [polypeptide binding]; other site 685038009545 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685038009546 catalytic residue [active] 685038009547 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 685038009548 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685038009549 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 685038009550 putative substrate binding pocket [chemical binding]; other site 685038009551 putative dimerization interface [polypeptide binding]; other site 685038009552 DNA-binding transcriptional activator TdcR; Provisional; Region: PRK11424 685038009553 glycerate kinase I; Provisional; Region: PRK10342 685038009554 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 685038009555 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 685038009556 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 685038009557 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 685038009558 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038009559 D-galactonate transporter; Region: 2A0114; TIGR00893 685038009560 putative substrate translocation pore; other site 685038009561 galactarate dehydratase; Region: galactar-dH20; TIGR03248 685038009562 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 685038009563 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 685038009564 putative regulator PrlF; Provisional; Region: PRK09974 685038009565 Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663 685038009566 DNA-binding transcriptional regulator AgaR; Provisional; Region: PRK09802 685038009567 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 685038009568 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 685038009569 tagatose 6-phosphate aldolase subunit KbaZ; Provisional; Region: PRK15458 685038009570 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 685038009571 active site 685038009572 phosphorylation site [posttranslational modification] 685038009573 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 685038009574 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 685038009575 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 685038009576 active pocket/dimerization site; other site 685038009577 active site 685038009578 phosphorylation site [posttranslational modification] 685038009579 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 685038009580 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 685038009581 active site 685038009582 dimer interface [polypeptide binding]; other site 685038009583 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 685038009584 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 685038009585 dimer interface [polypeptide binding]; other site 685038009586 active site 685038009587 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 685038009588 putative active site [active] 685038009589 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cd00453 685038009590 active site 685038009591 intersubunit interface [polypeptide binding]; other site 685038009592 zinc binding site [ion binding]; other site 685038009593 Na+ binding site [ion binding]; other site 685038009594 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 685038009595 active site 685038009596 phosphorylation site [posttranslational modification] 685038009597 PTS system N-acetylgalactosamine-specific transporter subunit IIC; Provisional; Region: PRK09757 685038009598 PTS system N-acetylgalactosamine-specific transporter subunit IID; Provisional; Region: PRK09855 685038009599 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 685038009600 active site 685038009601 trimer interface [polypeptide binding]; other site 685038009602 allosteric site; other site 685038009603 active site lid [active] 685038009604 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 685038009605 putative SAM binding site [chemical binding]; other site 685038009606 putative homodimer interface [polypeptide binding]; other site 685038009607 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 685038009608 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 685038009609 putative ligand binding site [chemical binding]; other site 685038009610 TIGR00252 family protein; Region: TIGR00252 685038009611 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 685038009612 dimer interface [polypeptide binding]; other site 685038009613 active site 685038009614 outer membrane lipoprotein; Provisional; Region: PRK11023 685038009615 BON domain; Region: BON; pfam04972 685038009616 BON domain; Region: BON; pfam04972 685038009617 Predicted permease; Region: DUF318; pfam03773 685038009618 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685038009619 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 685038009620 NAD(P) binding site [chemical binding]; other site 685038009621 active site 685038009622 hypothetical protein; Provisional; Region: PRK03467 685038009623 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 685038009624 GIY-YIG motif/motif A; other site 685038009625 putative active site [active] 685038009626 putative metal binding site [ion binding]; other site 685038009627 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 685038009628 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 685038009629 Coenzyme A binding pocket [chemical binding]; other site 685038009630 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 685038009631 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 685038009632 putative protease; Provisional; Region: PRK15447 685038009633 hypothetical protein; Provisional; Region: PRK10508 685038009634 tryptophan permease; Provisional; Region: PRK10483 685038009635 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 685038009636 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 685038009637 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 685038009638 ATP binding site [chemical binding]; other site 685038009639 Mg++ binding site [ion binding]; other site 685038009640 motif III; other site 685038009641 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 685038009642 nucleotide binding region [chemical binding]; other site 685038009643 ATP-binding site [chemical binding]; other site 685038009644 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 685038009645 putative RNA binding site [nucleotide binding]; other site 685038009646 lipoprotein NlpI; Provisional; Region: PRK11189 685038009647 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 685038009648 binding surface 685038009649 TPR motif; other site 685038009650 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 685038009651 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 685038009652 RNase E interface [polypeptide binding]; other site 685038009653 trimer interface [polypeptide binding]; other site 685038009654 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 685038009655 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 685038009656 RNase E interface [polypeptide binding]; other site 685038009657 trimer interface [polypeptide binding]; other site 685038009658 active site 685038009659 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 685038009660 putative nucleic acid binding region [nucleotide binding]; other site 685038009661 G-X-X-G motif; other site 685038009662 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 685038009663 RNA binding site [nucleotide binding]; other site 685038009664 domain interface; other site 685038009665 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 685038009666 16S/18S rRNA binding site [nucleotide binding]; other site 685038009667 S13e-L30e interaction site [polypeptide binding]; other site 685038009668 25S rRNA binding site [nucleotide binding]; other site 685038009669 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 685038009670 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 685038009671 RNA binding site [nucleotide binding]; other site 685038009672 active site 685038009673 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 685038009674 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 685038009675 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 685038009676 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 685038009677 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; cl01201 685038009678 translation initiation factor IF-2; Validated; Region: infB; PRK05306 685038009679 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 685038009680 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 685038009681 G1 box; other site 685038009682 putative GEF interaction site [polypeptide binding]; other site 685038009683 GTP/Mg2+ binding site [chemical binding]; other site 685038009684 Switch I region; other site 685038009685 G2 box; other site 685038009686 G3 box; other site 685038009687 Switch II region; other site 685038009688 G4 box; other site 685038009689 G5 box; other site 685038009690 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 685038009691 Translation-initiation factor 2; Region: IF-2; pfam11987 685038009692 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 685038009693 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 685038009694 NusA N-terminal domain; Region: NusA_N; pfam08529 685038009695 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 685038009696 RNA binding site [nucleotide binding]; other site 685038009697 homodimer interface [polypeptide binding]; other site 685038009698 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 685038009699 G-X-X-G motif; other site 685038009700 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 685038009701 G-X-X-G motif; other site 685038009702 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 685038009703 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 685038009704 hypothetical protein; Provisional; Region: PRK14641 685038009705 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 685038009706 putative oligomer interface [polypeptide binding]; other site 685038009707 putative RNA binding site [nucleotide binding]; other site 685038009708 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 685038009709 ANP binding site [chemical binding]; other site 685038009710 Substrate Binding Site II [chemical binding]; other site 685038009711 Substrate Binding Site I [chemical binding]; other site 685038009712 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 685038009713 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 685038009714 Sulfatase; Region: Sulfatase; pfam00884 685038009715 Preprotein translocase SecG subunit; Region: SecG; pfam03840 685038009716 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 685038009717 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 685038009718 active site 685038009719 substrate binding site [chemical binding]; other site 685038009720 metal binding site [ion binding]; metal-binding site 685038009721 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 685038009722 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 685038009723 substrate binding pocket [chemical binding]; other site 685038009724 dimer interface [polypeptide binding]; other site 685038009725 inhibitor binding site; inhibition site 685038009726 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 685038009727 FtsH Extracellular; Region: FtsH_ext; pfam06480 685038009728 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685038009729 Walker A motif; other site 685038009730 ATP binding site [chemical binding]; other site 685038009731 Walker B motif; other site 685038009732 arginine finger; other site 685038009733 Peptidase family M41; Region: Peptidase_M41; pfam01434 685038009734 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685038009735 S-adenosylmethionine binding site [chemical binding]; other site 685038009736 RNA-binding protein YhbY; Provisional; Region: PRK10343 685038009737 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 685038009738 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 685038009739 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 685038009740 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 685038009741 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 685038009742 GTPase CgtA; Reviewed; Region: obgE; PRK12298 685038009743 GTP1/OBG; Region: GTP1_OBG; pfam01018 685038009744 Obg GTPase; Region: Obg; cd01898 685038009745 G1 box; other site 685038009746 GTP/Mg2+ binding site [chemical binding]; other site 685038009747 Switch I region; other site 685038009748 G2 box; other site 685038009749 G3 box; other site 685038009750 Switch II region; other site 685038009751 G4 box; other site 685038009752 G5 box; other site 685038009753 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 685038009754 EamA-like transporter family; Region: EamA; pfam00892 685038009755 EamA-like transporter family; Region: EamA; pfam00892 685038009756 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 685038009757 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 685038009758 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 685038009759 substrate binding pocket [chemical binding]; other site 685038009760 chain length determination region; other site 685038009761 substrate-Mg2+ binding site; other site 685038009762 catalytic residues [active] 685038009763 aspartate-rich region 1; other site 685038009764 active site lid residues [active] 685038009765 aspartate-rich region 2; other site 685038009766 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 685038009767 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 685038009768 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 685038009769 hinge; other site 685038009770 active site 685038009771 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 685038009772 Predicted NTP binding protein (contains STAS domain) [General function prediction only]; Region: COG3113 685038009773 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 685038009774 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 685038009775 mce related protein; Region: MCE; pfam02470 685038009776 conserved hypothetical integral membrane protein; Region: TIGR00056 685038009777 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 685038009778 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 685038009779 Walker A/P-loop; other site 685038009780 ATP binding site [chemical binding]; other site 685038009781 Q-loop/lid; other site 685038009782 ABC transporter signature motif; other site 685038009783 Walker B; other site 685038009784 D-loop; other site 685038009785 H-loop/switch region; other site 685038009786 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 685038009787 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 685038009788 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 685038009789 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 685038009790 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 685038009791 putative active site [active] 685038009792 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 685038009793 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 685038009794 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 685038009795 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 685038009796 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 685038009797 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 685038009798 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 685038009799 Walker A/P-loop; other site 685038009800 ATP binding site [chemical binding]; other site 685038009801 Q-loop/lid; other site 685038009802 ABC transporter signature motif; other site 685038009803 Walker B; other site 685038009804 D-loop; other site 685038009805 H-loop/switch region; other site 685038009806 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 685038009807 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 685038009808 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 685038009809 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 685038009810 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 685038009811 30S subunit binding site; other site 685038009812 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 685038009813 active site 685038009814 phosphorylation site [posttranslational modification] 685038009815 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 685038009816 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 685038009817 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 685038009818 dimerization domain swap beta strand [polypeptide binding]; other site 685038009819 regulatory protein interface [polypeptide binding]; other site 685038009820 active site 685038009821 regulatory phosphorylation site [posttranslational modification]; other site 685038009822 hypothetical protein; Provisional; Region: PRK10345 685038009823 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 685038009824 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 685038009825 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 685038009826 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 685038009827 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 685038009828 conserved cys residue [active] 685038009829 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 685038009830 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 685038009831 putative active site [active] 685038009832 heme pocket [chemical binding]; other site 685038009833 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 685038009834 dimer interface [polypeptide binding]; other site 685038009835 phosphorylation site [posttranslational modification] 685038009836 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685038009837 ATP binding site [chemical binding]; other site 685038009838 Mg2+ binding site [ion binding]; other site 685038009839 G-X-G motif; other site 685038009840 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685038009841 active site 685038009842 phosphorylation site [posttranslational modification] 685038009843 intermolecular recognition site; other site 685038009844 dimerization interface [polypeptide binding]; other site 685038009845 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 685038009846 putative binding surface; other site 685038009847 active site 685038009848 radical SAM protein, TIGR01212 family; Region: TIGR01212 685038009849 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 685038009850 FeS/SAM binding site; other site 685038009851 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 685038009852 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 685038009853 active site 685038009854 dimer interface [polypeptide binding]; other site 685038009855 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 685038009856 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 685038009857 active site 685038009858 FMN binding site [chemical binding]; other site 685038009859 substrate binding site [chemical binding]; other site 685038009860 3Fe-4S cluster binding site [ion binding]; other site 685038009861 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 685038009862 domain interface; other site 685038009863 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 685038009864 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 685038009865 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 685038009866 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 685038009867 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 685038009868 uncharacterized protein, YhcH/YjgK/YiaL family; Region: TIGR00022 685038009869 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 685038009870 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 685038009871 nucleotide binding site [chemical binding]; other site 685038009872 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 685038009873 putative active site cavity [active] 685038009874 putative sialic acid transporter; Provisional; Region: PRK03893 685038009875 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038009876 putative substrate translocation pore; other site 685038009877 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 685038009878 inhibitor site; inhibition site 685038009879 active site 685038009880 dimer interface [polypeptide binding]; other site 685038009881 catalytic residue [active] 685038009882 transcriptional regulator NanR; Provisional; Region: PRK03837 685038009883 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 685038009884 DNA-binding site [nucleotide binding]; DNA binding site 685038009885 FCD domain; Region: FCD; pfam07729 685038009886 Stringent starvation protein B [General function prediction only]; Region: SspB; COG2969 685038009887 stringent starvation protein A; Provisional; Region: sspA; PRK09481 685038009888 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 685038009889 C-terminal domain interface [polypeptide binding]; other site 685038009890 putative GSH binding site (G-site) [chemical binding]; other site 685038009891 dimer interface [polypeptide binding]; other site 685038009892 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 685038009893 dimer interface [polypeptide binding]; other site 685038009894 N-terminal domain interface [polypeptide binding]; other site 685038009895 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 685038009896 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 685038009897 23S rRNA interface [nucleotide binding]; other site 685038009898 L3 interface [polypeptide binding]; other site 685038009899 Predicted ATPase [General function prediction only]; Region: COG1485 685038009900 hypothetical protein; Provisional; Region: PRK11677 685038009901 serine endoprotease; Provisional; Region: PRK10139 685038009902 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 685038009903 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 685038009904 protein binding site [polypeptide binding]; other site 685038009905 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 685038009906 serine endoprotease; Provisional; Region: PRK10898 685038009907 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 685038009908 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 685038009909 protein binding site [polypeptide binding]; other site 685038009910 malate dehydrogenase; Provisional; Region: PRK05086 685038009911 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 685038009912 NAD binding site [chemical binding]; other site 685038009913 dimerization interface [polypeptide binding]; other site 685038009914 Substrate binding site [chemical binding]; other site 685038009915 arginine repressor; Provisional; Region: PRK05066 685038009916 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 685038009917 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 685038009918 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 685038009919 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 685038009920 RNAase interaction site [polypeptide binding]; other site 685038009921 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 685038009922 Fusaric acid resistance protein family; Region: FUSC; pfam04632 685038009923 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 685038009924 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 685038009925 HlyD family secretion protein; Region: HlyD_3; pfam13437 685038009926 efflux system membrane protein; Provisional; Region: PRK11594 685038009927 transcriptional regulator; Provisional; Region: PRK10632 685038009928 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685038009929 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 685038009930 putative effector binding pocket; other site 685038009931 dimerization interface [polypeptide binding]; other site 685038009932 protease TldD; Provisional; Region: tldD; PRK10735 685038009933 hypothetical protein; Provisional; Region: PRK10899 685038009934 Protein of unknown function; Region: DUF3971; pfam13116 685038009935 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 685038009936 ribonuclease G; Provisional; Region: PRK11712 685038009937 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 685038009938 homodimer interface [polypeptide binding]; other site 685038009939 oligonucleotide binding site [chemical binding]; other site 685038009940 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 685038009941 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 685038009942 active site 685038009943 dimer interface [polypeptide binding]; other site 685038009944 rod shape-determining protein MreD; Provisional; Region: PRK11060 685038009945 rod shape-determining protein MreC; Region: mreC; TIGR00219 685038009946 rod shape-determining protein MreB; Provisional; Region: PRK13927 685038009947 MreB and similar proteins; Region: MreB_like; cd10225 685038009948 nucleotide binding site [chemical binding]; other site 685038009949 Mg binding site [ion binding]; other site 685038009950 putative protofilament interaction site [polypeptide binding]; other site 685038009951 RodZ interaction site [polypeptide binding]; other site 685038009952 regulatory protein CsrD; Provisional; Region: PRK11059 685038009953 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 685038009954 metal binding site [ion binding]; metal-binding site 685038009955 active site 685038009956 I-site; other site 685038009957 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 685038009958 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 685038009959 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 685038009960 NADP binding site [chemical binding]; other site 685038009961 dimer interface [polypeptide binding]; other site 685038009962 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 685038009963 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 685038009964 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 685038009965 carboxyltransferase (CT) interaction site; other site 685038009966 biotinylation site [posttranslational modification]; other site 685038009967 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 685038009968 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 685038009969 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 685038009970 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 685038009971 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 685038009972 active site 685038009973 catalytic residues [active] 685038009974 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 685038009975 substrate binding site [chemical binding]; other site 685038009976 ATP binding site [chemical binding]; other site 685038009977 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 685038009978 TM-ABC transporter signature motif; other site 685038009979 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 685038009980 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 685038009981 Walker A/P-loop; other site 685038009982 ATP binding site [chemical binding]; other site 685038009983 Q-loop/lid; other site 685038009984 ABC transporter signature motif; other site 685038009985 Walker B; other site 685038009986 D-loop; other site 685038009987 H-loop/switch region; other site 685038009988 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 685038009989 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 685038009990 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_12; cd06322 685038009991 putative ligand binding site [chemical binding]; other site 685038009992 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 685038009993 intersubunit interface [polypeptide binding]; other site 685038009994 active site 685038009995 zinc binding site [ion binding]; other site 685038009996 Na+ binding site [ion binding]; other site 685038009997 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 685038009998 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 685038009999 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 685038010000 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 685038010001 substrate binding site [chemical binding]; other site 685038010002 ATP binding site [chemical binding]; other site 685038010003 hypothetical protein; Provisional; Region: PRK10633 685038010004 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 685038010005 Na binding site [ion binding]; other site 685038010006 ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406 685038010007 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685038010008 S-adenosylmethionine binding site [chemical binding]; other site 685038010009 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 685038010010 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 685038010011 FMN binding site [chemical binding]; other site 685038010012 active site 685038010013 catalytic residues [active] 685038010014 substrate binding site [chemical binding]; other site 685038010015 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 685038010016 putative methyltransferase; Provisional; Region: PRK11524 685038010017 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685038010018 Protein of unknown function (DUF2556); Region: DUF2556; pfam10831 685038010019 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 685038010020 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685038010021 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 685038010022 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 685038010023 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 685038010024 HlyD family secretion protein; Region: HlyD_3; pfam13437 685038010025 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 685038010026 MMPL family; Region: MMPL; cl14618 685038010027 MMPL family; Region: MMPL; cl14618 685038010028 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 685038010029 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 685038010030 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 685038010031 substrate binding pocket [chemical binding]; other site 685038010032 membrane-bound complex binding site; other site 685038010033 hinge residues; other site 685038010034 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 685038010035 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 685038010036 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685038010037 dimer interface [polypeptide binding]; other site 685038010038 conserved gate region; other site 685038010039 putative PBP binding loops; other site 685038010040 ABC-ATPase subunit interface; other site 685038010041 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 685038010042 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685038010043 dimer interface [polypeptide binding]; other site 685038010044 conserved gate region; other site 685038010045 putative PBP binding loops; other site 685038010046 ABC-ATPase subunit interface; other site 685038010047 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 685038010048 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 685038010049 Walker A/P-loop; other site 685038010050 ATP binding site [chemical binding]; other site 685038010051 Q-loop/lid; other site 685038010052 ABC transporter signature motif; other site 685038010053 Walker B; other site 685038010054 D-loop; other site 685038010055 H-loop/switch region; other site 685038010056 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 685038010057 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 685038010058 trimer interface [polypeptide binding]; other site 685038010059 putative metal binding site [ion binding]; other site 685038010060 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 685038010061 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 685038010062 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 685038010063 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 685038010064 shikimate binding site; other site 685038010065 NAD(P) binding site [chemical binding]; other site 685038010066 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 685038010067 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 685038010068 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 685038010069 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 685038010070 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 685038010071 hypothetical protein; Validated; Region: PRK03430 685038010072 hypothetical protein; Provisional; Region: PRK10736 685038010073 DNA protecting protein DprA; Region: dprA; TIGR00732 685038010074 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 685038010075 active site 685038010076 catalytic residues [active] 685038010077 metal binding site [ion binding]; metal-binding site 685038010078 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 685038010079 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 685038010080 putative active site [active] 685038010081 substrate binding site [chemical binding]; other site 685038010082 putative cosubstrate binding site; other site 685038010083 catalytic site [active] 685038010084 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 685038010085 substrate binding site [chemical binding]; other site 685038010086 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 685038010087 putative RNA binding site [nucleotide binding]; other site 685038010088 16S rRNA methyltransferase B; Provisional; Region: PRK10901 685038010089 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685038010090 S-adenosylmethionine binding site [chemical binding]; other site 685038010091 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 685038010092 TrkA-N domain; Region: TrkA_N; pfam02254 685038010093 TrkA-C domain; Region: TrkA_C; pfam02080 685038010094 TrkA-N domain; Region: TrkA_N; pfam02254 685038010095 TrkA-C domain; Region: TrkA_C; pfam02080 685038010096 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 685038010097 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 685038010098 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 685038010099 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 685038010100 DNA binding residues [nucleotide binding] 685038010101 dimer interface [polypeptide binding]; other site 685038010102 metal binding site [ion binding]; metal-binding site 685038010103 hypothetical protein; Provisional; Region: PRK10203 685038010104 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 685038010105 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 685038010106 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 685038010107 alphaNTD homodimer interface [polypeptide binding]; other site 685038010108 alphaNTD - beta interaction site [polypeptide binding]; other site 685038010109 alphaNTD - beta' interaction site [polypeptide binding]; other site 685038010110 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 685038010111 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 685038010112 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 685038010113 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 685038010114 RNA binding surface [nucleotide binding]; other site 685038010115 30S ribosomal protein S11; Validated; Region: PRK05309 685038010116 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 685038010117 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 685038010118 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 685038010119 SecY translocase; Region: SecY; pfam00344 685038010120 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 685038010121 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 685038010122 23S rRNA binding site [nucleotide binding]; other site 685038010123 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 685038010124 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 685038010125 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 685038010126 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 685038010127 23S rRNA interface [nucleotide binding]; other site 685038010128 5S rRNA interface [nucleotide binding]; other site 685038010129 L27 interface [polypeptide binding]; other site 685038010130 L5 interface [polypeptide binding]; other site 685038010131 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 685038010132 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 685038010133 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 685038010134 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 685038010135 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 685038010136 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 685038010137 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 685038010138 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 685038010139 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 685038010140 RNA binding site [nucleotide binding]; other site 685038010141 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 685038010142 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 685038010143 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 685038010144 23S rRNA interface [nucleotide binding]; other site 685038010145 putative translocon interaction site; other site 685038010146 signal recognition particle (SRP54) interaction site; other site 685038010147 L23 interface [polypeptide binding]; other site 685038010148 trigger factor interaction site; other site 685038010149 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 685038010150 23S rRNA interface [nucleotide binding]; other site 685038010151 5S rRNA interface [nucleotide binding]; other site 685038010152 putative antibiotic binding site [chemical binding]; other site 685038010153 L25 interface [polypeptide binding]; other site 685038010154 L27 interface [polypeptide binding]; other site 685038010155 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 685038010156 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 685038010157 G-X-X-G motif; other site 685038010158 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 685038010159 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 685038010160 protein-rRNA interface [nucleotide binding]; other site 685038010161 putative translocon binding site; other site 685038010162 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 685038010163 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 685038010164 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 685038010165 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 685038010166 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 685038010167 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 685038010168 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 685038010169 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 685038010170 protein secretion protein GspB; Provisional; Region: PRK09697 685038010171 AAA domain; Region: AAA_22; pfam13401 685038010172 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 685038010173 Type II secretory pathway, component PulC [Intracellular trafficking and secretion]; Region: PulC; COG3031 685038010174 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 685038010175 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 685038010176 type II secretion system protein D; Region: type_II_gspD; TIGR02517 685038010177 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 685038010178 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 685038010179 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 685038010180 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 685038010181 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 685038010182 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 685038010183 Walker A motif; other site 685038010184 ATP binding site [chemical binding]; other site 685038010185 Walker B motif; other site 685038010186 type II secretion system protein F; Region: GspF; TIGR02120 685038010187 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 685038010188 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 685038010189 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 685038010190 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 685038010191 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 685038010192 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 685038010193 Type II transport protein GspH; Region: GspH; pfam12019 685038010194 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 685038010195 type II secretion system protein I; Region: gspI; TIGR01707 685038010196 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 685038010197 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 685038010198 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 685038010199 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 685038010200 Type II secretory pathway, component PulK [Intracellular trafficking and secretion]; Region: PulK; COG3156 685038010201 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 685038010202 Type II secretory pathway, component PulL [Intracellular trafficking and secretion]; Region: PulL; COG3297 685038010203 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 685038010204 GspL periplasmic domain; Region: GspL_C; pfam12693 685038010205 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 685038010206 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 685038010207 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 685038010208 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 685038010209 Ferritin-like domain; Region: Ferritin; pfam00210 685038010210 heme binding site [chemical binding]; other site 685038010211 ferroxidase pore; other site 685038010212 ferroxidase diiron center [ion binding]; other site 685038010213 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 685038010214 Chitin-binding domain type 3; Region: ChtBD3; smart00495 685038010215 Chitin-binding domain type 3; Region: ChtBD3; smart00495 685038010216 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 685038010217 aromatic chitin/cellulose binding site residues [chemical binding]; other site 685038010218 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 685038010219 active site 685038010220 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 685038010221 elongation factor Tu; Reviewed; Region: PRK00049 685038010222 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 685038010223 G1 box; other site 685038010224 GEF interaction site [polypeptide binding]; other site 685038010225 GTP/Mg2+ binding site [chemical binding]; other site 685038010226 Switch I region; other site 685038010227 G2 box; other site 685038010228 G3 box; other site 685038010229 Switch II region; other site 685038010230 G4 box; other site 685038010231 G5 box; other site 685038010232 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 685038010233 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 685038010234 Antibiotic Binding Site [chemical binding]; other site 685038010235 elongation factor G; Reviewed; Region: PRK00007 685038010236 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 685038010237 G1 box; other site 685038010238 putative GEF interaction site [polypeptide binding]; other site 685038010239 GTP/Mg2+ binding site [chemical binding]; other site 685038010240 Switch I region; other site 685038010241 G2 box; other site 685038010242 G3 box; other site 685038010243 Switch II region; other site 685038010244 G4 box; other site 685038010245 G5 box; other site 685038010246 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 685038010247 Elongation Factor G, domain II; Region: EFG_II; pfam14492 685038010248 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 685038010249 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 685038010250 30S ribosomal protein S7; Validated; Region: PRK05302 685038010251 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 685038010252 S17 interaction site [polypeptide binding]; other site 685038010253 S8 interaction site; other site 685038010254 16S rRNA interaction site [nucleotide binding]; other site 685038010255 streptomycin interaction site [chemical binding]; other site 685038010256 23S rRNA interaction site [nucleotide binding]; other site 685038010257 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 685038010258 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 685038010259 sulfur relay protein TusC; Validated; Region: PRK00211 685038010260 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 685038010261 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 685038010262 YheO-like PAS domain; Region: PAS_6; pfam08348 685038010263 HTH domain; Region: HTH_22; pfam13309 685038010264 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 685038010265 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 685038010266 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 685038010267 phi X174 lysis protein; Provisional; Region: PRK02793 685038010268 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10737 685038010269 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 685038010270 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 685038010271 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 685038010272 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 685038010273 TrkA-N domain; Region: TrkA_N; pfam02254 685038010274 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 685038010275 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 685038010276 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 685038010277 ABC transporter; Region: ABC_tran_2; pfam12848 685038010278 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 685038010279 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 685038010280 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 685038010281 putative hydrolase; Provisional; Region: PRK10985 685038010282 hypothetical protein; Provisional; Region: PRK04966 685038010283 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 685038010284 active site 685038010285 hypothetical protein; Provisional; Region: PRK10738 685038010286 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 685038010287 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 685038010288 ligand binding site [chemical binding]; other site 685038010289 flexible hinge region; other site 685038010290 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 685038010291 putative switch regulator; other site 685038010292 non-specific DNA interactions [nucleotide binding]; other site 685038010293 DNA binding site [nucleotide binding] 685038010294 sequence specific DNA binding site [nucleotide binding]; other site 685038010295 putative cAMP binding site [chemical binding]; other site 685038010296 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 685038010297 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 685038010298 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 685038010299 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 685038010300 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 685038010301 inhibitor-cofactor binding pocket; inhibition site 685038010302 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685038010303 catalytic residue [active] 685038010304 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 685038010305 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 685038010306 glutamine binding [chemical binding]; other site 685038010307 catalytic triad [active] 685038010308 cell filamentation protein Fic; Provisional; Region: PRK10347 685038010309 Protein of unknown function (DUF2559); Region: DUF2559; cl08097 685038010310 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 685038010311 substrate binding site [chemical binding]; other site 685038010312 putative transporter; Provisional; Region: PRK03699 685038010313 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038010314 putative substrate translocation pore; other site 685038010315 nitrite reductase subunit NirD; Provisional; Region: PRK14989 685038010316 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 685038010317 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 685038010318 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 685038010319 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 685038010320 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 685038010321 nitrite transporter NirC; Provisional; Region: PRK11562 685038010322 siroheme synthase; Provisional; Region: cysG; PRK10637 685038010323 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 685038010324 Sirohaem biosynthesis protein central; Region: Sirohm_synth_M; pfam14824 685038010325 Sirohaem synthase dimerization region; Region: CysG_dimeriser; pfam10414 685038010326 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 685038010327 active site 685038010328 SAM binding site [chemical binding]; other site 685038010329 homodimer interface [polypeptide binding]; other site 685038010330 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 685038010331 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 685038010332 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 685038010333 catalytic residue [active] 685038010334 Protein of unknown function; Region: YhfT; pfam10797 685038010335 Protein of unknown function DUF2620; Region: DUF2620; pfam10941 685038010336 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 685038010337 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 685038010338 active site 685038010339 substrate binding pocket [chemical binding]; other site 685038010340 homodimer interaction site [polypeptide binding]; other site 685038010341 putative mutase; Provisional; Region: PRK12383 685038010342 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme yhfX; Region: PLPDE_III_yhfX_like; cd06811 685038010343 dimer interface [polypeptide binding]; other site 685038010344 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 685038010345 active site 685038010346 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 685038010347 substrate binding site [chemical binding]; other site 685038010348 catalytic residue [active] 685038010349 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 685038010350 Helix-turn-helix domain; Region: HTH_41; pfam14502 685038010351 YhfZ C-terminal domain; Region: YhfZ_C; pfam14503 685038010352 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927 685038010353 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 685038010354 active site 685038010355 HIGH motif; other site 685038010356 dimer interface [polypeptide binding]; other site 685038010357 KMSKS motif; other site 685038010358 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 685038010359 phosphoglycolate phosphatase; Provisional; Region: PRK13222 685038010360 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 685038010361 motif II; other site 685038010362 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 685038010363 substrate binding site [chemical binding]; other site 685038010364 hexamer interface [polypeptide binding]; other site 685038010365 metal binding site [ion binding]; metal-binding site 685038010366 DNA adenine methylase; Provisional; Region: PRK10904 685038010367 cell division protein DamX; Validated; Region: PRK10905 685038010368 Sporulation related domain; Region: SPOR; pfam05036 685038010369 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 685038010370 active site 685038010371 dimer interface [polypeptide binding]; other site 685038010372 metal binding site [ion binding]; metal-binding site 685038010373 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 685038010374 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 685038010375 ADP binding site [chemical binding]; other site 685038010376 magnesium binding site [ion binding]; other site 685038010377 putative shikimate binding site; other site 685038010378 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 685038010379 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 685038010380 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 685038010381 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 685038010382 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 685038010383 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 685038010384 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 685038010385 Transglycosylase; Region: Transgly; pfam00912 685038010386 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 685038010387 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 685038010388 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 685038010389 ADP-ribose binding site [chemical binding]; other site 685038010390 dimer interface [polypeptide binding]; other site 685038010391 active site 685038010392 nudix motif; other site 685038010393 metal binding site [ion binding]; metal-binding site 685038010394 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 685038010395 GMP/IMP nucleotidase; Provisional; Region: PRK14988 685038010396 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 685038010397 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 685038010398 motif II; other site 685038010399 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 685038010400 RNA binding surface [nucleotide binding]; other site 685038010401 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 685038010402 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 685038010403 dimerization interface [polypeptide binding]; other site 685038010404 domain crossover interface; other site 685038010405 redox-dependent activation switch; other site 685038010406 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 685038010407 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 685038010408 active site 685038010409 substrate-binding site [chemical binding]; other site 685038010410 metal-binding site [ion binding] 685038010411 ATP binding site [chemical binding]; other site 685038010412 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 685038010413 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 685038010414 dimerization interface [polypeptide binding]; other site 685038010415 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 685038010416 dimer interface [polypeptide binding]; other site 685038010417 phosphorylation site [posttranslational modification] 685038010418 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685038010419 ATP binding site [chemical binding]; other site 685038010420 Mg2+ binding site [ion binding]; other site 685038010421 G-X-G motif; other site 685038010422 osmolarity response regulator; Provisional; Region: ompR; PRK09468 685038010423 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685038010424 active site 685038010425 phosphorylation site [posttranslational modification] 685038010426 intermolecular recognition site; other site 685038010427 dimerization interface [polypeptide binding]; other site 685038010428 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 685038010429 DNA binding site [nucleotide binding] 685038010430 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 685038010431 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 685038010432 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 685038010433 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 685038010434 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 685038010435 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 685038010436 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 685038010437 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 685038010438 RNA binding site [nucleotide binding]; other site 685038010439 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 685038010440 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 685038010441 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 685038010442 G1 box; other site 685038010443 GTP/Mg2+ binding site [chemical binding]; other site 685038010444 Switch I region; other site 685038010445 G2 box; other site 685038010446 G3 box; other site 685038010447 Switch II region; other site 685038010448 G4 box; other site 685038010449 G5 box; other site 685038010450 Nucleoside recognition; Region: Gate; pfam07670 685038010451 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 685038010452 Nucleoside recognition; Region: Gate; pfam07670 685038010453 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 685038010454 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 685038010455 carboxylesterase BioH; Provisional; Region: PRK10349 685038010456 Putative lysophospholipase; Region: Hydrolase_4; cl19140 685038010457 Putative lysophospholipase; Region: Hydrolase_4; cl19140 685038010458 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 685038010459 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 685038010460 active site 685038010461 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 685038010462 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 685038010463 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 685038010464 high-affinity gluconate transporter; Provisional; Region: PRK14984 685038010465 GntP family permease; Region: GntP_permease; pfam02447 685038010466 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 685038010467 4-alpha-glucanotransferase; Region: malQ; TIGR00217 685038010468 maltodextrin phosphorylase; Provisional; Region: PRK14985 685038010469 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 685038010470 homodimer interface [polypeptide binding]; other site 685038010471 active site pocket [active] 685038010472 transcriptional regulator MalT; Provisional; Region: PRK04841 685038010473 AAA ATPase domain; Region: AAA_16; pfam13191 685038010474 Cohesin loading factor; Region: Cohesin_load; pfam10345 685038010475 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 685038010476 DNA binding residues [nucleotide binding] 685038010477 dimerization interface [polypeptide binding]; other site 685038010478 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 685038010479 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 685038010480 putative active site [active] 685038010481 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690 685038010482 tRNA-splicing ligase RtcB; Region: RtcB; pfam01139 685038010483 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 685038010484 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 685038010485 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685038010486 Walker A motif; other site 685038010487 ATP binding site [chemical binding]; other site 685038010488 Walker B motif; other site 685038010489 arginine finger; other site 685038010490 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 685038010491 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 685038010492 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 685038010493 intramembrane serine protease GlpG; Provisional; Region: PRK10907 685038010494 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 685038010495 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 685038010496 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 685038010497 active site residue [active] 685038010498 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 685038010499 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 685038010500 hypothetical protein; Provisional; Region: PRK09781; cl08057 685038010501 Fimbrial protein; Region: Fimbrial; cl01416 685038010502 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 685038010503 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 685038010504 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 685038010505 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 685038010506 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 685038010507 outer membrane usher protein; Provisional; Region: PRK15193 685038010508 PapC N-terminal domain; Region: PapC_N; pfam13954 685038010509 Outer membrane usher protein; Region: Usher; pfam00577 685038010510 PapC C-terminal domain; Region: PapC_C; pfam13953 685038010511 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 685038010512 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 685038010513 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 685038010514 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 685038010515 glycogen phosphorylase; Provisional; Region: PRK14986 685038010516 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 685038010517 homodimer interface [polypeptide binding]; other site 685038010518 active site pocket [active] 685038010519 glycogen synthase; Provisional; Region: glgA; PRK00654 685038010520 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 685038010521 ADP-binding pocket [chemical binding]; other site 685038010522 homodimer interface [polypeptide binding]; other site 685038010523 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 685038010524 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 685038010525 ligand binding site; other site 685038010526 oligomer interface; other site 685038010527 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 685038010528 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 685038010529 dimer interface [polypeptide binding]; other site 685038010530 N-terminal domain interface [polypeptide binding]; other site 685038010531 sulfate 1 binding site; other site 685038010532 glycogen debranching enzyme; Provisional; Region: PRK03705 685038010533 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 685038010534 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 685038010535 active site 685038010536 catalytic site [active] 685038010537 glycogen branching enzyme; Provisional; Region: PRK05402 685038010538 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 685038010539 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 685038010540 active site 685038010541 catalytic site [active] 685038010542 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 685038010543 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 685038010544 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 685038010545 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 685038010546 putative antibiotic transporter; Provisional; Region: PRK10739 685038010547 low affinity gluconate transporter; Provisional; Region: PRK10472 685038010548 GntP family permease; Region: GntP_permease; pfam02447 685038010549 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 685038010550 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 685038010551 ATP-binding site [chemical binding]; other site 685038010552 Gluconate-6-phosphate binding site [chemical binding]; other site 685038010553 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 685038010554 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 685038010555 DNA binding site [nucleotide binding] 685038010556 domain linker motif; other site 685038010557 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 685038010558 putative ligand binding site [chemical binding]; other site 685038010559 putative dimerization interface [polypeptide binding]; other site 685038010560 Pirin-related protein [General function prediction only]; Region: COG1741 685038010561 Pirin; Region: Pirin; pfam02678 685038010562 putative oxidoreductase; Provisional; Region: PRK10206 685038010563 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 685038010564 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 685038010565 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 685038010566 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 685038010567 Coenzyme A binding pocket [chemical binding]; other site 685038010568 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 685038010569 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 685038010570 active site 685038010571 Immunity protein 19; Region: Imm19; pfam15567 685038010572 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 685038010573 hypothetical protein; Provisional; Region: PRK10350 685038010574 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 685038010575 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 685038010576 putative active site [active] 685038010577 catalytic site [active] 685038010578 putative metal binding site [ion binding]; other site 685038010579 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 685038010580 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 685038010581 Walker A/P-loop; other site 685038010582 ATP binding site [chemical binding]; other site 685038010583 Q-loop/lid; other site 685038010584 ABC transporter signature motif; other site 685038010585 Walker B; other site 685038010586 D-loop; other site 685038010587 H-loop/switch region; other site 685038010588 TOBE domain; Region: TOBE_2; pfam08402 685038010589 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 685038010590 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685038010591 dimer interface [polypeptide binding]; other site 685038010592 conserved gate region; other site 685038010593 putative PBP binding loops; other site 685038010594 ABC-ATPase subunit interface; other site 685038010595 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 685038010596 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685038010597 dimer interface [polypeptide binding]; other site 685038010598 conserved gate region; other site 685038010599 putative PBP binding loops; other site 685038010600 ABC-ATPase subunit interface; other site 685038010601 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 685038010602 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 685038010603 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 685038010604 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 685038010605 Walker A/P-loop; other site 685038010606 ATP binding site [chemical binding]; other site 685038010607 Q-loop/lid; other site 685038010608 ABC transporter signature motif; other site 685038010609 Walker B; other site 685038010610 D-loop; other site 685038010611 H-loop/switch region; other site 685038010612 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 685038010613 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 685038010614 Walker A/P-loop; other site 685038010615 ATP binding site [chemical binding]; other site 685038010616 Q-loop/lid; other site 685038010617 ABC transporter signature motif; other site 685038010618 Walker B; other site 685038010619 D-loop; other site 685038010620 H-loop/switch region; other site 685038010621 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 685038010622 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 685038010623 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 685038010624 TM-ABC transporter signature motif; other site 685038010625 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 685038010626 TM-ABC transporter signature motif; other site 685038010627 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 685038010628 dimerization interface [polypeptide binding]; other site 685038010629 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 685038010630 ligand binding site [chemical binding]; other site 685038010631 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 685038010632 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 685038010633 dimerization interface [polypeptide binding]; other site 685038010634 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 685038010635 ligand binding site [chemical binding]; other site 685038010636 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 685038010637 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 685038010638 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 685038010639 DNA binding residues [nucleotide binding] 685038010640 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 685038010641 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 685038010642 cell division protein FtsE; Provisional; Region: PRK10908 685038010643 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685038010644 Walker A/P-loop; other site 685038010645 ATP binding site [chemical binding]; other site 685038010646 Q-loop/lid; other site 685038010647 ABC transporter signature motif; other site 685038010648 Walker B; other site 685038010649 D-loop; other site 685038010650 H-loop/switch region; other site 685038010651 Mitochondria Localisation Sequence; Region: AIF-MLS; pfam14962 685038010652 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 685038010653 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 685038010654 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 685038010655 P loop; other site 685038010656 GTP binding site [chemical binding]; other site 685038010657 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685038010658 S-adenosylmethionine binding site [chemical binding]; other site 685038010659 hypothetical protein; Provisional; Region: PRK10910 685038010660 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 685038010661 Predicted membrane protein [Function unknown]; Region: COG3714 685038010662 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 685038010663 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 685038010664 metal-binding site [ion binding] 685038010665 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 685038010666 Soluble P-type ATPase [General function prediction only]; Region: COG4087 685038010667 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 685038010668 CPxP motif; other site 685038010669 hypothetical protein; Provisional; Region: PRK11212 685038010670 hypothetical protein; Provisional; Region: PRK11615 685038010671 major facilitator superfamily transporter; Provisional; Region: PRK05122 685038010672 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038010673 putative substrate translocation pore; other site 685038010674 Domain of unknown function DUF20; Region: UPF0118; cl00465 685038010675 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 685038010676 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 685038010677 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 685038010678 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 685038010679 substrate binding site [chemical binding]; other site 685038010680 nickel transporter permease NikB; Provisional; Region: PRK10352 685038010681 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685038010682 dimer interface [polypeptide binding]; other site 685038010683 conserved gate region; other site 685038010684 putative PBP binding loops; other site 685038010685 ABC-ATPase subunit interface; other site 685038010686 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 685038010687 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685038010688 dimer interface [polypeptide binding]; other site 685038010689 conserved gate region; other site 685038010690 putative PBP binding loops; other site 685038010691 ABC-ATPase subunit interface; other site 685038010692 nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418 685038010693 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 685038010694 Walker A/P-loop; other site 685038010695 ATP binding site [chemical binding]; other site 685038010696 Q-loop/lid; other site 685038010697 ABC transporter signature motif; other site 685038010698 Walker B; other site 685038010699 D-loop; other site 685038010700 H-loop/switch region; other site 685038010701 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 685038010702 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 685038010703 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 685038010704 Walker A/P-loop; other site 685038010705 ATP binding site [chemical binding]; other site 685038010706 Q-loop/lid; other site 685038010707 ABC transporter signature motif; other site 685038010708 Walker B; other site 685038010709 D-loop; other site 685038010710 H-loop/switch region; other site 685038010711 nickel responsive regulator; Provisional; Region: PRK02967 685038010712 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 685038010713 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 685038010714 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 685038010715 DNA-binding site [nucleotide binding]; DNA binding site 685038010716 UTRA domain; Region: UTRA; pfam07702 685038010717 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 685038010718 active site 685038010719 phosphorylation site [posttranslational modification] 685038010720 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 685038010721 active site 685038010722 P-loop; other site 685038010723 phosphorylation site [posttranslational modification] 685038010724 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 685038010725 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 685038010726 uncharacterized subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_1; cd07774 685038010727 putative N- and C-terminal domain interface [polypeptide binding]; other site 685038010728 putative active site [active] 685038010729 putative MgATP binding site [chemical binding]; other site 685038010730 catalytic site [active] 685038010731 metal binding site [ion binding]; metal-binding site 685038010732 putative carbohydrate binding site [chemical binding]; other site 685038010733 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 685038010734 dimerization domain swap beta strand [polypeptide binding]; other site 685038010735 regulatory protein interface [polypeptide binding]; other site 685038010736 active site 685038010737 regulatory phosphorylation site [posttranslational modification]; other site 685038010738 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 685038010739 intersubunit interface [polypeptide binding]; other site 685038010740 active site 685038010741 zinc binding site [ion binding]; other site 685038010742 Na+ binding site [ion binding]; other site 685038010743 Structural glycoprotein p40/gp41 conserved region; Region: Baculo_gp41; pfam04700 685038010744 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 685038010745 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 685038010746 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 685038010747 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 685038010748 Walker A/P-loop; other site 685038010749 ATP binding site [chemical binding]; other site 685038010750 Q-loop/lid; other site 685038010751 ABC transporter signature motif; other site 685038010752 Walker B; other site 685038010753 D-loop; other site 685038010754 H-loop/switch region; other site 685038010755 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 685038010756 Walker A/P-loop; other site 685038010757 ATP binding site [chemical binding]; other site 685038010758 Q-loop/lid; other site 685038010759 ABC transporter signature motif; other site 685038010760 Walker B; other site 685038010761 D-loop; other site 685038010762 H-loop/switch region; other site 685038010763 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 685038010764 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 685038010765 HlyD family secretion protein; Region: HlyD; pfam00529 685038010766 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 685038010767 HlyD family secretion protein; Region: HlyD_3; pfam13437 685038010768 Protein of unknown function (DUF2776); Region: DUF2776; pfam10951 685038010769 Predicted flavoproteins [General function prediction only]; Region: COG2081 685038010770 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 685038010771 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 685038010772 universal stress protein UspB; Provisional; Region: PRK04960 685038010773 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 685038010774 Ligand Binding Site [chemical binding]; other site 685038010775 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 685038010776 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038010777 putative substrate translocation pore; other site 685038010778 putative methyltransferase; Provisional; Region: PRK10742 685038010779 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685038010780 S-adenosylmethionine binding site [chemical binding]; other site 685038010781 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 685038010782 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 685038010783 active site 685038010784 Zn binding site [ion binding]; other site 685038010785 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 685038010786 glutathione reductase; Validated; Region: PRK06116 685038010787 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 685038010788 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 685038010789 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 685038010790 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 685038010791 catalytic residues [active] 685038010792 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 685038010793 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 685038010794 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 685038010795 DNA binding residues [nucleotide binding] 685038010796 dimerization interface [polypeptide binding]; other site 685038010797 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 685038010798 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 685038010799 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 685038010800 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 685038010801 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 685038010802 N-terminal plug; other site 685038010803 ligand-binding site [chemical binding]; other site 685038010804 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 685038010805 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 685038010806 putative hemin binding site; other site 685038010807 coproporphyrinogen III oxidase; Provisional; Region: PRK09058 685038010808 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 685038010809 FeS/SAM binding site; other site 685038010810 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugX; COG3721 685038010811 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 685038010812 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 685038010813 NAD(P) binding site [chemical binding]; other site 685038010814 putative active site [active] 685038010815 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 685038010816 ABC-ATPase subunit interface; other site 685038010817 dimer interface [polypeptide binding]; other site 685038010818 putative PBP binding regions; other site 685038010819 ABC-type hemin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG4559 685038010820 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 685038010821 Walker A/P-loop; other site 685038010822 ATP binding site [chemical binding]; other site 685038010823 Q-loop/lid; other site 685038010824 ABC transporter signature motif; other site 685038010825 Walker B; other site 685038010826 D-loop; other site 685038010827 H-loop/switch region; other site 685038010828 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 685038010829 MgtC family; Region: MgtC; pfam02308 685038010830 acid-resistance protein; Provisional; Region: hdeB; PRK11566 685038010831 acid-resistance protein; Provisional; Region: PRK10208 685038010832 acid-resistance membrane protein; Provisional; Region: PRK10209 685038010833 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 685038010834 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 685038010835 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 685038010836 HlyD family secretion protein; Region: HlyD_3; pfam13437 685038010837 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 685038010838 MMPL family; Region: MMPL; cl14618 685038010839 MMPL family; Region: MMPL; cl14618 685038010840 transcriptional regulator YdeO; Provisional; Region: PRK09940 685038010841 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 685038010842 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 685038010843 DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978 685038010844 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 685038010845 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 685038010846 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 685038010847 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685038010848 catalytic residue [active] 685038010849 Haem-binding domain; Region: Haem_bd; pfam14376 685038010850 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 685038010851 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 685038010852 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 685038010853 trehalase; Provisional; Region: treF; PRK13270 685038010854 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 685038010855 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 685038010856 DNA binding residues [nucleotide binding] 685038010857 dimerization interface [polypeptide binding]; other site 685038010858 Transcriptional regulator [Transcription]; Region: LysR; COG0583 685038010859 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685038010860 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 685038010861 putative effector binding pocket; other site 685038010862 putative dimerization interface [polypeptide binding]; other site 685038010863 inner membrane protein YhjD; Region: TIGR00766 685038010864 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038010865 metabolite-proton symporter; Region: 2A0106; TIGR00883 685038010866 putative substrate translocation pore; other site 685038010867 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 685038010868 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 685038010869 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 685038010870 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 685038010871 substrate binding site [chemical binding]; other site 685038010872 ATP binding site [chemical binding]; other site 685038010873 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 685038010874 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 685038010875 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 685038010876 putative diguanylate cyclase; Provisional; Region: PRK13561 685038010877 HAMP domain; Region: HAMP; pfam00672 685038010878 diguanylate cyclase; Region: GGDEF; smart00267 685038010879 metal binding site [ion binding]; metal-binding site 685038010880 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 685038010881 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 685038010882 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 685038010883 binding surface 685038010884 TPR motif; other site 685038010885 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 685038010886 binding surface 685038010887 TPR motif; other site 685038010888 Trypsin-like peptidase domain; Region: Trypsin_2; cl19303 685038010889 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 685038010890 TPR motif; other site 685038010891 binding surface 685038010892 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 685038010893 endo-1,4-D-glucanase; Provisional; Region: PRK11097 685038010894 cellulose synthase regulator protein; Provisional; Region: PRK11114 685038010895 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 685038010896 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 685038010897 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 685038010898 DXD motif; other site 685038010899 PilZ domain; Region: PilZ; pfam07238 685038010900 cell division protein; Provisional; Region: PRK10037 685038010901 YhjQ protein; Region: YhjQ; pfam06564 685038010902 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 685038010903 Protein of unknown function (DUF2819); Region: DUF2819; cl17862 685038010904 celllulose biosynthesis operon protein BcsF/YhjT; Region: cellullose_BcsF; TIGR03493 685038010905 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 685038010906 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 685038010907 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 685038010908 serine transporter; Region: stp; TIGR00814 685038010909 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 685038010910 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 685038010911 Walker A/P-loop; other site 685038010912 ATP binding site [chemical binding]; other site 685038010913 Q-loop/lid; other site 685038010914 ABC transporter signature motif; other site 685038010915 Walker B; other site 685038010916 D-loop; other site 685038010917 H-loop/switch region; other site 685038010918 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 685038010919 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 685038010920 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 685038010921 Walker A/P-loop; other site 685038010922 ATP binding site [chemical binding]; other site 685038010923 Q-loop/lid; other site 685038010924 ABC transporter signature motif; other site 685038010925 Walker B; other site 685038010926 D-loop; other site 685038010927 H-loop/switch region; other site 685038010928 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 685038010929 dipeptide transporter; Provisional; Region: PRK10913 685038010930 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 685038010931 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685038010932 dimer interface [polypeptide binding]; other site 685038010933 conserved gate region; other site 685038010934 putative PBP binding loops; other site 685038010935 ABC-ATPase subunit interface; other site 685038010936 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 685038010937 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685038010938 dimer interface [polypeptide binding]; other site 685038010939 conserved gate region; other site 685038010940 putative PBP binding loops; other site 685038010941 ABC-ATPase subunit interface; other site 685038010942 antimicrobial peptide ABC transporter periplasmic binding protein SapA; Provisional; Region: PRK15109 685038010943 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 685038010944 peptide binding site [polypeptide binding]; other site 685038010945 phosphoethanolamine transferase; Provisional; Region: PRK11560 685038010946 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 685038010947 Sulfatase; Region: Sulfatase; pfam00884 685038010948 long polar fimbrial protein LpfE; Provisional; Region: PRK15205 685038010949 Fimbrial protein; Region: Fimbrial; cl01416 685038010950 long polar fimbrial outer membrane usher protein LpfC; Provisional; Region: PRK15207 685038010951 PapC N-terminal domain; Region: PapC_N; pfam13954 685038010952 Outer membrane usher protein; Region: Usher; pfam00577 685038010953 PapC C-terminal domain; Region: PapC_C; pfam13953 685038010954 long polar fimbrial chaperone LpfB; Provisional; Region: PRK15208 685038010955 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 685038010956 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 685038010957 long polar fimbrial protein LpfA; Provisional; Region: PRK15209 685038010958 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 685038010959 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038010960 putative substrate translocation pore; other site 685038010961 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 685038010962 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 685038010963 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 685038010964 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 685038010965 Coenzyme A binding pocket [chemical binding]; other site 685038010966 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 685038010967 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 685038010968 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 685038010969 molybdopterin cofactor binding site [chemical binding]; other site 685038010970 substrate binding site [chemical binding]; other site 685038010971 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 685038010972 molybdopterin cofactor binding site; other site 685038010973 putative outer membrane lipoprotein; Provisional; Region: PRK10510 685038010974 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 685038010975 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 685038010976 ligand binding site [chemical binding]; other site 685038010977 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 685038010978 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 685038010979 dimerization interface [polypeptide binding]; other site 685038010980 ligand binding site [chemical binding]; other site 685038010981 NADP binding site [chemical binding]; other site 685038010982 catalytic site [active] 685038010983 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 685038010984 Predicted transcriptional regulator [Transcription]; Region: COG2944 685038010985 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 685038010986 non-specific DNA binding site [nucleotide binding]; other site 685038010987 salt bridge; other site 685038010988 sequence-specific DNA binding site [nucleotide binding]; other site 685038010989 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 685038010990 DNA-binding site [nucleotide binding]; DNA binding site 685038010991 RNA-binding motif; other site 685038010992 small toxic polypeptide; Provisional; Region: PRK09759 685038010993 glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211 685038010994 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 685038010995 DALR anticodon binding domain; Region: DALR_1; pfam05746 685038010996 anticodon binding site; other site 685038010997 tRNA binding surface [nucleotide binding]; other site 685038010998 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 685038010999 dimer interface [polypeptide binding]; other site 685038011000 motif 1; other site 685038011001 active site 685038011002 motif 2; other site 685038011003 motif 3; other site 685038011004 YsaB-like lipoprotein; Region: YsaB; pfam13983 685038011005 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 685038011006 hypothetical protein; Provisional; Region: PRK11383 685038011007 yiaA/B two helix domain; Region: YiaAB; pfam05360 685038011008 yiaA/B two helix domain; Region: YiaAB; pfam05360 685038011009 hypothetical protein; Provisional; Region: PRK11403 685038011010 yiaA/B two helix domain; Region: YiaAB; pfam05360 685038011011 xylulokinase; Provisional; Region: PRK15027 685038011012 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 685038011013 N- and C-terminal domain interface [polypeptide binding]; other site 685038011014 active site 685038011015 MgATP binding site [chemical binding]; other site 685038011016 catalytic site [active] 685038011017 metal binding site [ion binding]; metal-binding site 685038011018 xylulose binding site [chemical binding]; other site 685038011019 homodimer interface [polypeptide binding]; other site 685038011020 xylose isomerase; Provisional; Region: PRK05474 685038011021 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 685038011022 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 685038011023 putative ligand binding site [chemical binding]; other site 685038011024 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 685038011025 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 685038011026 Walker A/P-loop; other site 685038011027 ATP binding site [chemical binding]; other site 685038011028 Q-loop/lid; other site 685038011029 ABC transporter signature motif; other site 685038011030 Walker B; other site 685038011031 D-loop; other site 685038011032 H-loop/switch region; other site 685038011033 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 685038011034 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 685038011035 TM-ABC transporter signature motif; other site 685038011036 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 685038011037 putative dimerization interface [polypeptide binding]; other site 685038011038 Transcriptional regulators [Transcription]; Region: PurR; COG1609 685038011039 putative ligand binding site [chemical binding]; other site 685038011040 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 685038011041 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 685038011042 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 685038011043 hypothetical protein; Provisional; Region: PRK10356 685038011044 Lysozyme subfamily 2; Region: LYZ2; smart00047 685038011045 alpha-amylase; Reviewed; Region: malS; PRK09505 685038011046 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 685038011047 active site 685038011048 catalytic site [active] 685038011049 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 685038011050 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 685038011051 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685038011052 homodimer interface [polypeptide binding]; other site 685038011053 catalytic residue [active] 685038011054 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 685038011055 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 685038011056 Transcriptional regulator [Transcription]; Region: IclR; COG1414 685038011057 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 685038011058 Bacterial transcriptional regulator; Region: IclR; pfam01614 685038011059 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 685038011060 uncharacterized protein, YhcH/YjgK/YiaL family; Region: TIGR00022 685038011061 2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM; Provisional; Region: PRK09877 685038011062 L-dehydroascorbate transporter large permease subunit; Provisional; Region: PRK15060 685038011063 DctM-like transporters; Region: DctM; pfam06808 685038011064 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 685038011065 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 685038011066 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 685038011067 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 685038011068 putative N- and C-terminal domain interface [polypeptide binding]; other site 685038011069 putative active site [active] 685038011070 MgATP binding site [chemical binding]; other site 685038011071 catalytic site [active] 685038011072 metal binding site [ion binding]; metal-binding site 685038011073 putative xylulose binding site [chemical binding]; other site 685038011074 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 685038011075 active site 685038011076 dimer interface [polypeptide binding]; other site 685038011077 magnesium binding site [ion binding]; other site 685038011078 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 685038011079 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 685038011080 AP (apurinic/apyrimidinic) site pocket; other site 685038011081 DNA interaction; other site 685038011082 Metal-binding active site; metal-binding site 685038011083 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 685038011084 intersubunit interface [polypeptide binding]; other site 685038011085 active site 685038011086 Zn2+ binding site [ion binding]; other site 685038011087 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II and Staphylococcus aureus AldA1 (SACOL0154)-like; Region: ALDH_ACDHII_AcoD-like; cd07559 685038011088 NAD(P) binding site [chemical binding]; other site 685038011089 catalytic residues [active] 685038011090 Fic family protein [Function unknown]; Region: COG3177 685038011091 Fic/DOC family; Region: Fic; pfam02661 685038011092 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 685038011093 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 685038011094 dimer interface [polypeptide binding]; other site 685038011095 active site 685038011096 metal binding site [ion binding]; metal-binding site 685038011097 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 685038011098 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 685038011099 G1 box; other site 685038011100 putative GEF interaction site [polypeptide binding]; other site 685038011101 GTP/Mg2+ binding site [chemical binding]; other site 685038011102 Switch I region; other site 685038011103 G2 box; other site 685038011104 G3 box; other site 685038011105 Switch II region; other site 685038011106 G4 box; other site 685038011107 G5 box; other site 685038011108 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 685038011109 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 685038011110 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 685038011111 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 685038011112 selenocysteine synthase; Provisional; Region: PRK04311 685038011113 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 685038011114 L-seryl-tRNA selenium transferase; Region: SelA; pfam03841 685038011115 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 685038011116 catalytic residue [active] 685038011117 putative glutathione S-transferase; Provisional; Region: PRK10357 685038011118 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 685038011119 putative C-terminal domain interface [polypeptide binding]; other site 685038011120 putative GSH binding site (G-site) [chemical binding]; other site 685038011121 putative dimer interface [polypeptide binding]; other site 685038011122 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 685038011123 dimer interface [polypeptide binding]; other site 685038011124 N-terminal domain interface [polypeptide binding]; other site 685038011125 putative substrate binding pocket (H-site) [chemical binding]; other site 685038011126 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 685038011127 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 685038011128 HlyD family secretion protein; Region: HlyD_3; pfam13437 685038011129 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 685038011130 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 685038011131 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 685038011132 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 685038011133 active site 685038011134 P-loop; other site 685038011135 phosphorylation site [posttranslational modification] 685038011136 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 685038011137 active site 685038011138 phosphorylation site [posttranslational modification] 685038011139 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 685038011140 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 685038011141 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 685038011142 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 685038011143 hypothetical protein; Provisional; Region: PRK11020 685038011144 Protein of unknown function (DUF3251); Region: DUF3251; cl08186 685038011145 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 685038011146 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 685038011147 trimer interface [polypeptide binding]; other site 685038011148 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 685038011149 trimer interface [polypeptide binding]; other site 685038011150 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 685038011151 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 685038011152 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 685038011153 trimer interface [polypeptide binding]; other site 685038011154 Coiled stalk of trimeric autotransporter adhesin; Region: YadA_stalk; pfam05662 685038011155 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 685038011156 trimer interface [polypeptide binding]; other site 685038011157 Coiled stalk of trimeric autotransporter adhesin; Region: YadA_stalk; pfam05662 685038011158 YadA-like C-terminal region; Region: YadA_anchor; pfam03895 685038011159 L-lactate permease; Provisional; Region: PRK10420 685038011160 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 685038011161 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 685038011162 DNA-binding site [nucleotide binding]; DNA binding site 685038011163 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 685038011164 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 685038011165 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 685038011166 active site 685038011167 substrate binding site [chemical binding]; other site 685038011168 FMN binding site [chemical binding]; other site 685038011169 putative catalytic residues [active] 685038011170 putative rRNA methylase; Provisional; Region: PRK10358 685038011171 serine acetyltransferase; Provisional; Region: cysE; PRK11132 685038011172 Serine acetyltransferase, N-terminal; Region: SATase_N; smart00971 685038011173 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 685038011174 trimer interface [polypeptide binding]; other site 685038011175 active site 685038011176 substrate binding site [chemical binding]; other site 685038011177 CoA binding site [chemical binding]; other site 685038011178 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 685038011179 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 685038011180 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 685038011181 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 685038011182 SecA binding site; other site 685038011183 Preprotein binding site; other site 685038011184 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 685038011185 GSH binding site [chemical binding]; other site 685038011186 catalytic residues [active] 685038011187 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 685038011188 active site residue [active] 685038011189 phosphoglyceromutase; Provisional; Region: PRK05434 685038011190 AmiB activator; Provisional; Region: PRK11637 685038011191 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 685038011192 HemX; Region: HemX; cl19375 685038011193 Peptidase family M23; Region: Peptidase_M23; pfam01551 685038011194 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 685038011195 NodB motif; other site 685038011196 putative active site [active] 685038011197 putative catalytic site [active] 685038011198 Zn binding site [ion binding]; other site 685038011199 putative glycosyl transferase; Provisional; Region: PRK10073 685038011200 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 685038011201 active site 685038011202 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 685038011203 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 685038011204 NAD(P) binding site [chemical binding]; other site 685038011205 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 685038011206 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 685038011207 substrate-cofactor binding pocket; other site 685038011208 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685038011209 catalytic residue [active] 685038011210 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 685038011211 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 685038011212 NADP binding site [chemical binding]; other site 685038011213 homopentamer interface [polypeptide binding]; other site 685038011214 substrate binding site [chemical binding]; other site 685038011215 active site 685038011216 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 685038011217 putative active site [active] 685038011218 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 685038011219 putative active site [active] 685038011220 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 685038011221 O-Antigen ligase; Region: Wzy_C; pfam04932 685038011222 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 685038011223 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 685038011224 active site 685038011225 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 685038011226 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 685038011227 Ligand binding site; other site 685038011228 metal-binding site 685038011229 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 685038011230 Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; pfam06176 685038011231 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 685038011232 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 685038011233 Ligand binding site; other site 685038011234 metal-binding site 685038011235 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 685038011236 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 685038011237 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 685038011238 Ligand binding site; other site 685038011239 metal-binding site 685038011240 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 685038011241 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 685038011242 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 685038011243 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 685038011244 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 685038011245 putative active site [active] 685038011246 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 685038011247 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 685038011248 Glycosyl transferases group 1; Region: Glycos_transf_1; cl19138 685038011249 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 685038011250 active site 685038011251 (T/H)XGH motif; other site 685038011252 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 685038011253 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 685038011254 DNA binding site [nucleotide binding] 685038011255 catalytic residue [active] 685038011256 H2TH interface [polypeptide binding]; other site 685038011257 putative catalytic residues [active] 685038011258 turnover-facilitating residue; other site 685038011259 intercalation triad [nucleotide binding]; other site 685038011260 8OG recognition residue [nucleotide binding]; other site 685038011261 putative reading head residues; other site 685038011262 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 685038011263 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 685038011264 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 685038011265 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 685038011266 hypothetical protein; Reviewed; Region: PRK00024 685038011267 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 685038011268 MPN+ (JAMM) motif; other site 685038011269 Zinc-binding site [ion binding]; other site 685038011270 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 685038011271 Flavoprotein; Region: Flavoprotein; cl19190 685038011272 DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127 685038011273 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 685038011274 trimer interface [polypeptide binding]; other site 685038011275 active site 685038011276 division inhibitor protein; Provisional; Region: slmA; PRK09480 685038011277 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685038011278 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 685038011279 active site 685038011280 ribonuclease PH; Reviewed; Region: rph; PRK00173 685038011281 Ribonuclease PH; Region: RNase_PH_bact; cd11362 685038011282 hexamer interface [polypeptide binding]; other site 685038011283 active site 685038011284 hypothetical protein; Provisional; Region: PRK11820 685038011285 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 685038011286 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 685038011287 DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525 685038011288 BRO family, N-terminal domain; Region: Bro-N; pfam02498 685038011289 Predicted membrane protein [Function unknown]; Region: COG2860 685038011290 UPF0126 domain; Region: UPF0126; pfam03458 685038011291 UPF0126 domain; Region: UPF0126; pfam03458 685038011292 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 685038011293 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 685038011294 nucleotide binding pocket [chemical binding]; other site 685038011295 K-X-D-G motif; other site 685038011296 catalytic site [active] 685038011297 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 685038011298 Guanylate kinase; Region: Guanylate_kin; pfam00625 685038011299 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 685038011300 catalytic site [active] 685038011301 G-X2-G-X-G-K; other site 685038011302 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 685038011303 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 685038011304 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 685038011305 Zn2+ binding site [ion binding]; other site 685038011306 Mg2+ binding site [ion binding]; other site 685038011307 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 685038011308 synthetase active site [active] 685038011309 NTP binding site [chemical binding]; other site 685038011310 metal binding site [ion binding]; metal-binding site 685038011311 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 685038011312 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 685038011313 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 685038011314 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 685038011315 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 685038011316 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 685038011317 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 685038011318 generic binding surface II; other site 685038011319 ssDNA binding site; other site 685038011320 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 685038011321 ATP binding site [chemical binding]; other site 685038011322 putative Mg++ binding site [ion binding]; other site 685038011323 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 685038011324 nucleotide binding region [chemical binding]; other site 685038011325 ATP-binding site [chemical binding]; other site 685038011326 Sodium/glutamate symporter; Region: Glt_symporter; cl19414 685038011327 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 685038011328 Sulfate transporter family; Region: Sulfate_transp; cl19250 685038011329 AsmA family; Region: AsmA; pfam05170 685038011330 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 685038011331 Protein of unknown function (DUF1498); Region: DUF1498; pfam07385 685038011332 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 685038011333 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 685038011334 nucleotide binding site [chemical binding]; other site 685038011335 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 685038011336 intersubunit interface [polypeptide binding]; other site 685038011337 active site 685038011338 zinc binding site [ion binding]; other site 685038011339 Na+ binding site [ion binding]; other site 685038011340 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 685038011341 intersubunit interface [polypeptide binding]; other site 685038011342 active site 685038011343 zinc binding site [ion binding]; other site 685038011344 Na+ binding site [ion binding]; other site 685038011345 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 685038011346 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 685038011347 active site 685038011348 P-loop; other site 685038011349 phosphorylation site [posttranslational modification] 685038011350 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 685038011351 active site 685038011352 phosphorylation site [posttranslational modification] 685038011353 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 685038011354 HTH domain; Region: HTH_11; pfam08279 685038011355 Mga helix-turn-helix domain; Region: Mga; pfam05043 685038011356 PRD domain; Region: PRD; pfam00874 685038011357 PRD domain; Region: PRD; pfam00874 685038011358 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 685038011359 active site 685038011360 P-loop; other site 685038011361 phosphorylation site [posttranslational modification] 685038011362 putative alpha-glucosidase; Provisional; Region: PRK10658 685038011363 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 685038011364 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 685038011365 active site 685038011366 homotrimer interface [polypeptide binding]; other site 685038011367 catalytic site [active] 685038011368 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 685038011369 putative transporter; Provisional; Region: PRK11462 685038011370 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 685038011371 Virulence protein [General function prediction only]; Region: COG3943 685038011372 EamA-like transporter family; Region: EamA; pfam00892 685038011373 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 685038011374 EamA-like transporter family; Region: EamA; pfam00892 685038011375 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 685038011376 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 685038011377 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038011378 putative substrate translocation pore; other site 685038011379 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 685038011380 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 685038011381 cryptic adenine deaminase; Provisional; Region: PRK10027 685038011382 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 685038011383 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 685038011384 active site 685038011385 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 685038011386 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038011387 putative substrate translocation pore; other site 685038011388 regulatory protein UhpC; Provisional; Region: PRK11663 685038011389 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038011390 putative substrate translocation pore; other site 685038011391 sensory histidine kinase UhpB; Provisional; Region: PRK11644 685038011392 MASE1; Region: MASE1; pfam05231 685038011393 Histidine kinase; Region: HisKA_3; pfam07730 685038011394 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685038011395 ATP binding site [chemical binding]; other site 685038011396 Mg2+ binding site [ion binding]; other site 685038011397 G-X-G motif; other site 685038011398 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 685038011399 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685038011400 active site 685038011401 phosphorylation site [posttranslational modification] 685038011402 intermolecular recognition site; other site 685038011403 dimerization interface [polypeptide binding]; other site 685038011404 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 685038011405 DNA binding residues [nucleotide binding] 685038011406 dimerization interface [polypeptide binding]; other site 685038011407 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 685038011408 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 685038011409 putative valine binding site [chemical binding]; other site 685038011410 dimer interface [polypeptide binding]; other site 685038011411 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 685038011412 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 685038011413 PYR/PP interface [polypeptide binding]; other site 685038011414 dimer interface [polypeptide binding]; other site 685038011415 TPP binding site [chemical binding]; other site 685038011416 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 685038011417 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 685038011418 TPP-binding site [chemical binding]; other site 685038011419 dimer interface [polypeptide binding]; other site 685038011420 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 685038011421 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038011422 putative substrate translocation pore; other site 685038011423 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 685038011424 Domain of unknown function (DUF202); Region: DUF202; pfam02656 685038011425 Predicted membrane protein [Function unknown]; Region: COG2149 685038011426 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 685038011427 Sulfatase; Region: Sulfatase; pfam00884 685038011428 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 685038011429 Na binding site [ion binding]; other site 685038011430 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 685038011431 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 685038011432 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 685038011433 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 685038011434 putative transporter; Validated; Region: PRK03818 685038011435 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 685038011436 TrkA-C domain; Region: TrkA_C; pfam02080 685038011437 TrkA-C domain; Region: TrkA_C; pfam02080 685038011438 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 685038011439 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 685038011440 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 685038011441 putative dimer interface [polypeptide binding]; other site 685038011442 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 685038011443 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 685038011444 putative dimer interface [polypeptide binding]; other site 685038011445 hypothetical protein; Provisional; Region: PRK11616 685038011446 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 685038011447 putative oxidoreductase; Provisional; Region: PRK11445 685038011448 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 685038011449 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038011450 D-galactonate transporter; Region: 2A0114; TIGR00893 685038011451 putative substrate translocation pore; other site 685038011452 galactonate dehydratase; Provisional; Region: PRK14017 685038011453 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 685038011454 putative active site pocket [active] 685038011455 putative metal binding site [ion binding]; other site 685038011456 Entner-Doudoroff aldolase; Region: eda; TIGR01182 685038011457 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 685038011458 active site 685038011459 intersubunit interface [polypeptide binding]; other site 685038011460 catalytic residue [active] 685038011461 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 685038011462 Transcriptional regulators [Transcription]; Region: FadR; COG2186 685038011463 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 685038011464 DNA-binding site [nucleotide binding]; DNA binding site 685038011465 FCD domain; Region: FCD; pfam07729 685038011466 hypothetical protein; Provisional; Region: PRK10215 685038011467 sugar phosphate phosphatase; Provisional; Region: PRK10513 685038011468 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 685038011469 active site 685038011470 motif I; other site 685038011471 motif II; other site 685038011472 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 685038011473 hypothetical protein; Provisional; Region: PRK11426 685038011474 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 685038011475 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685038011476 ATP binding site [chemical binding]; other site 685038011477 Mg2+ binding site [ion binding]; other site 685038011478 G-X-G motif; other site 685038011479 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 685038011480 anchoring element; other site 685038011481 dimer interface [polypeptide binding]; other site 685038011482 ATP binding site [chemical binding]; other site 685038011483 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 685038011484 active site 685038011485 putative metal-binding site [ion binding]; other site 685038011486 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 685038011487 recF protein; Region: recf; TIGR00611 685038011488 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685038011489 Walker A/P-loop; other site 685038011490 ATP binding site [chemical binding]; other site 685038011491 Q-loop/lid; other site 685038011492 ABC transporter signature motif; other site 685038011493 Walker B; other site 685038011494 D-loop; other site 685038011495 H-loop/switch region; other site 685038011496 DNA polymerase III subunit beta; Validated; Region: PRK05643 685038011497 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 685038011498 putative DNA binding surface [nucleotide binding]; other site 685038011499 dimer interface [polypeptide binding]; other site 685038011500 beta-clamp/clamp loader binding surface; other site 685038011501 beta-clamp/translesion DNA polymerase binding surface; other site 685038011502 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 685038011503 DnaA N-terminal domain; Region: DnaA_N; pfam11638 685038011504 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 685038011505 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685038011506 Walker A motif; other site 685038011507 ATP binding site [chemical binding]; other site 685038011508 Walker B motif; other site 685038011509 arginine finger; other site 685038011510 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 685038011511 DnaA box-binding interface [nucleotide binding]; other site 685038011512 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 685038011513 ribonuclease P; Reviewed; Region: rnpA; PRK01732 685038011514 hypothetical protein; Validated; Region: PRK00041 685038011515 membrane protein insertase; Provisional; Region: PRK01318 685038011516 YidC periplasmic domain; Region: YidC_periplas; pfam14849 685038011517 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 685038011518 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 685038011519 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 685038011520 trmE is a tRNA modification GTPase; Region: trmE; cd04164 685038011521 G1 box; other site 685038011522 GTP/Mg2+ binding site [chemical binding]; other site 685038011523 Switch I region; other site 685038011524 G2 box; other site 685038011525 Switch II region; other site 685038011526 G3 box; other site 685038011527 G4 box; other site 685038011528 G5 box; other site 685038011529 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 685038011530 Tryptophanase [Amino acid transport and metabolism]; Region: TnaA; COG3033 685038011531 tryptophanase, leader peptide-associated; Region: tnaA_trp_ase; TIGR02617 685038011532 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 685038011533 catalytic residue [active] 685038011534 tryptophan permease TnaB; Provisional; Region: PRK09664 685038011535 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 685038011536 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 685038011537 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038011538 putative substrate translocation pore; other site 685038011539 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 685038011540 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685038011541 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 685038011542 substrate binding pocket [chemical binding]; other site 685038011543 dimerization interface [polypeptide binding]; other site 685038011544 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 685038011545 Predicted flavoprotein [General function prediction only]; Region: COG0431 685038011546 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 685038011547 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 685038011548 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 685038011549 active site 685038011550 motif I; other site 685038011551 motif II; other site 685038011552 putative inner membrane protein; Provisional; Region: PRK09823 685038011553 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 685038011554 active site 685038011555 trimer interface [polypeptide binding]; other site 685038011556 allosteric site; other site 685038011557 active site lid [active] 685038011558 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 685038011559 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 685038011560 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 685038011561 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 685038011562 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 685038011563 maltoporin; Provisional; Region: lamB; PRK09360 685038011564 trimer interface; other site 685038011565 sugar binding site [chemical binding]; other site 685038011566 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 685038011567 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 685038011568 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 685038011569 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 685038011570 active site turn [active] 685038011571 phosphorylation site [posttranslational modification] 685038011572 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 685038011573 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 685038011574 HPr interaction site; other site 685038011575 glycerol kinase (GK) interaction site [polypeptide binding]; other site 685038011576 active site 685038011577 phosphorylation site [posttranslational modification] 685038011578 transcriptional antiterminator BglG; Provisional; Region: PRK09772 685038011579 CAT RNA binding domain; Region: CAT_RBD; pfam03123 685038011580 PRD domain; Region: PRD; pfam00874 685038011581 PRD domain; Region: PRD; pfam00874 685038011582 transcriptional regulator PhoU; Provisional; Region: PRK11115 685038011583 PhoU domain; Region: PhoU; pfam01895 685038011584 PhoU domain; Region: PhoU; pfam01895 685038011585 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 685038011586 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 685038011587 Walker A/P-loop; other site 685038011588 ATP binding site [chemical binding]; other site 685038011589 Q-loop/lid; other site 685038011590 ABC transporter signature motif; other site 685038011591 Walker B; other site 685038011592 D-loop; other site 685038011593 H-loop/switch region; other site 685038011594 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 685038011595 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685038011596 dimer interface [polypeptide binding]; other site 685038011597 conserved gate region; other site 685038011598 putative PBP binding loops; other site 685038011599 ABC-ATPase subunit interface; other site 685038011600 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 685038011601 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685038011602 dimer interface [polypeptide binding]; other site 685038011603 conserved gate region; other site 685038011604 putative PBP binding loops; other site 685038011605 ABC-ATPase subunit interface; other site 685038011606 phosphate ABC transporter periplasmic substrate-binding protein PstS; Provisional; Region: PRK10918 685038011607 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 685038011608 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 685038011609 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 685038011610 glutaminase active site [active] 685038011611 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 685038011612 dimer interface [polypeptide binding]; other site 685038011613 active site 685038011614 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 685038011615 dimer interface [polypeptide binding]; other site 685038011616 active site 685038011617 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 685038011618 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 685038011619 Substrate binding site; other site 685038011620 Mg++ binding site; other site 685038011621 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 685038011622 active site 685038011623 substrate binding site [chemical binding]; other site 685038011624 CoA binding site [chemical binding]; other site 685038011625 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 685038011626 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 685038011627 gamma subunit interface [polypeptide binding]; other site 685038011628 epsilon subunit interface [polypeptide binding]; other site 685038011629 LBP interface [polypeptide binding]; other site 685038011630 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 685038011631 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 685038011632 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 685038011633 alpha subunit interaction interface [polypeptide binding]; other site 685038011634 Walker A motif; other site 685038011635 ATP binding site [chemical binding]; other site 685038011636 Walker B motif; other site 685038011637 inhibitor binding site; inhibition site 685038011638 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 685038011639 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 685038011640 core domain interface [polypeptide binding]; other site 685038011641 delta subunit interface [polypeptide binding]; other site 685038011642 epsilon subunit interface [polypeptide binding]; other site 685038011643 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 685038011644 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 685038011645 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 685038011646 beta subunit interaction interface [polypeptide binding]; other site 685038011647 Walker A motif; other site 685038011648 ATP binding site [chemical binding]; other site 685038011649 Walker B motif; other site 685038011650 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 685038011651 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 685038011652 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 685038011653 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 685038011654 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 685038011655 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 685038011656 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 685038011657 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 685038011658 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685038011659 S-adenosylmethionine binding site [chemical binding]; other site 685038011660 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 685038011661 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 685038011662 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 685038011663 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 685038011664 FMN-binding protein MioC; Provisional; Region: PRK09004 685038011665 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 685038011666 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 685038011667 putative DNA binding site [nucleotide binding]; other site 685038011668 putative Zn2+ binding site [ion binding]; other site 685038011669 AsnC family; Region: AsnC_trans_reg; pfam01037 685038011670 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 685038011671 dimer interface [polypeptide binding]; other site 685038011672 active site 685038011673 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2425 685038011674 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 685038011675 metal ion-dependent adhesion site (MIDAS); other site 685038011676 regulatory ATPase RavA; Provisional; Region: PRK13531 685038011677 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685038011678 Walker A motif; other site 685038011679 ATP binding site [chemical binding]; other site 685038011680 Walker B motif; other site 685038011681 arginine finger; other site 685038011682 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 685038011683 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 685038011684 D-ribose pyranase; Provisional; Region: PRK11797 685038011685 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 685038011686 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 685038011687 Walker A/P-loop; other site 685038011688 ATP binding site [chemical binding]; other site 685038011689 Q-loop/lid; other site 685038011690 ABC transporter signature motif; other site 685038011691 Walker B; other site 685038011692 D-loop; other site 685038011693 H-loop/switch region; other site 685038011694 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 685038011695 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 685038011696 TM-ABC transporter signature motif; other site 685038011697 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 685038011698 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 685038011699 ligand binding site [chemical binding]; other site 685038011700 dimerization interface [polypeptide binding]; other site 685038011701 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 685038011702 substrate binding site [chemical binding]; other site 685038011703 dimer interface [polypeptide binding]; other site 685038011704 ATP binding site [chemical binding]; other site 685038011705 transcriptional repressor RbsR; Provisional; Region: PRK10423 685038011706 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 685038011707 DNA binding site [nucleotide binding] 685038011708 domain linker motif; other site 685038011709 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 685038011710 dimerization interface [polypeptide binding]; other site 685038011711 ligand binding site [chemical binding]; other site 685038011712 putative transporter; Provisional; Region: PRK10504 685038011713 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038011714 putative substrate translocation pore; other site 685038011715 Transcriptional regulators [Transcription]; Region: FadR; COG2186 685038011716 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 685038011717 DNA-binding site [nucleotide binding]; DNA binding site 685038011718 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 685038011719 transcriptional regulator HdfR; Provisional; Region: PRK03601 685038011720 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685038011721 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 685038011722 dimerization interface [polypeptide binding]; other site 685038011723 hypothetical protein; Provisional; Region: PRK11027 685038011724 putative ATP-dependent protease; Provisional; Region: PRK09862 685038011725 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 685038011726 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685038011727 Walker A motif; other site 685038011728 ATP binding site [chemical binding]; other site 685038011729 Walker B motif; other site 685038011730 arginine finger; other site 685038011731 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 685038011732 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 685038011733 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 685038011734 PYR/PP interface [polypeptide binding]; other site 685038011735 dimer interface [polypeptide binding]; other site 685038011736 TPP binding site [chemical binding]; other site 685038011737 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 685038011738 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 685038011739 TPP-binding site [chemical binding]; other site 685038011740 dimer interface [polypeptide binding]; other site 685038011741 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 685038011742 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 685038011743 homodimer interface [polypeptide binding]; other site 685038011744 substrate-cofactor binding pocket; other site 685038011745 catalytic residue [active] 685038011746 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 685038011747 threonine dehydratase; Reviewed; Region: PRK09224 685038011748 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 685038011749 tetramer interface [polypeptide binding]; other site 685038011750 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685038011751 catalytic residue [active] 685038011752 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 685038011753 putative Ile/Val binding site [chemical binding]; other site 685038011754 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 685038011755 putative Ile/Val binding site [chemical binding]; other site 685038011756 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685038011757 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 685038011758 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 685038011759 putative dimerization interface [polypeptide binding]; other site 685038011760 ketol-acid reductoisomerase; Validated; Region: PRK05225 685038011761 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 685038011762 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 685038011763 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 685038011764 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 685038011765 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 685038011766 Part of AAA domain; Region: AAA_19; pfam13245 685038011767 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 685038011768 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 685038011769 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 685038011770 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 685038011771 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 685038011772 ATP binding site [chemical binding]; other site 685038011773 Mg++ binding site [ion binding]; other site 685038011774 motif III; other site 685038011775 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 685038011776 nucleotide binding region [chemical binding]; other site 685038011777 ATP-binding site [chemical binding]; other site 685038011778 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 685038011779 catalytic residues [active] 685038011780 putative rho operon leader peptide; Provisional; Region: PRK09979 685038011781 transcription termination factor Rho; Provisional; Region: rho; PRK09376 685038011782 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 685038011783 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 685038011784 RNA binding site [nucleotide binding]; other site 685038011785 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 685038011786 multimer interface [polypeptide binding]; other site 685038011787 Walker A motif; other site 685038011788 ATP binding site [chemical binding]; other site 685038011789 Walker B motif; other site 685038011790 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380 685038011791 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 685038011792 Mg++ binding site [ion binding]; other site 685038011793 putative catalytic motif [active] 685038011794 substrate binding site [chemical binding]; other site 685038011795 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 685038011796 Chain length determinant protein; Region: Wzz; pfam02706 685038011797 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 685038011798 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 685038011799 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 685038011800 active site 685038011801 homodimer interface [polypeptide binding]; other site 685038011802 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 685038011803 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 685038011804 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 685038011805 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 685038011806 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 685038011807 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 685038011808 NAD binding site [chemical binding]; other site 685038011809 substrate binding site [chemical binding]; other site 685038011810 homodimer interface [polypeptide binding]; other site 685038011811 active site 685038011812 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 685038011813 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 685038011814 substrate binding site; other site 685038011815 tetramer interface; other site 685038011816 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 685038011817 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 685038011818 inhibitor-cofactor binding pocket; inhibition site 685038011819 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685038011820 catalytic residue [active] 685038011821 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 685038011822 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 685038011823 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 685038011824 putative common antigen polymerase; Provisional; Region: PRK02975 685038011825 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 685038011826 putative transport protein YifK; Provisional; Region: PRK10746 685038011827 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 685038011828 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 685038011829 FeS/SAM binding site; other site 685038011830 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 685038011831 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 685038011832 Sulfatase; Region: Sulfatase; pfam00884 685038011833 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 685038011834 HemY protein N-terminus; Region: HemY_N; pfam07219 685038011835 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 685038011836 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 685038011837 active site 685038011838 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 685038011839 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 685038011840 domain interfaces; other site 685038011841 active site 685038011842 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 685038011843 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 685038011844 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 685038011845 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 685038011846 putative iron binding site [ion binding]; other site 685038011847 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 685038011848 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 685038011849 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 685038011850 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 685038011851 hypothetical protein; Provisional; Region: PRK10963 685038011852 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 685038011853 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 685038011854 active site 685038011855 Int/Topo IB signature motif; other site 685038011856 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 685038011857 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 685038011858 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 685038011859 motif II; other site 685038011860 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 685038011861 Part of AAA domain; Region: AAA_19; pfam13245 685038011862 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 685038011863 Uncharacterized conserved protein [Function unknown]; Region: COG1912 685038011864 Predicted periplasmic protein [Function unknown]; Region: COG3698 685038011865 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 685038011866 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 685038011867 Cl binding site [ion binding]; other site 685038011868 oligomer interface [polypeptide binding]; other site 685038011869 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 685038011870 Protein of unknown function (DUF3289); Region: DUF3289; cl11840 685038011871 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 685038011872 Multidrug resistance efflux transporter; Region: EmrE; cl19304 685038011873 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 685038011874 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 685038011875 CoenzymeA binding site [chemical binding]; other site 685038011876 subunit interaction site [polypeptide binding]; other site 685038011877 PHB binding site; other site 685038011878 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 685038011879 dimerization interface [polypeptide binding]; other site 685038011880 substrate binding site [chemical binding]; other site 685038011881 active site 685038011882 calcium binding site [ion binding]; other site 685038011883 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 685038011884 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 685038011885 ATP binding site [chemical binding]; other site 685038011886 putative Mg++ binding site [ion binding]; other site 685038011887 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 685038011888 nucleotide binding region [chemical binding]; other site 685038011889 ATP-binding site [chemical binding]; other site 685038011890 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 685038011891 Helicase and RNase D C-terminal; Region: HRDC; smart00341 685038011892 threonine efflux system; Provisional; Region: PRK10229 685038011893 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 685038011894 lysophospholipase L2; Provisional; Region: PRK10749 685038011895 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 685038011896 putative hydrolase; Provisional; Region: PRK10976 685038011897 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 685038011898 active site 685038011899 motif I; other site 685038011900 motif II; other site 685038011901 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 685038011902 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 685038011903 EamA-like transporter family; Region: EamA; pfam00892 685038011904 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 685038011905 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685038011906 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 685038011907 putative dimerization interface [polypeptide binding]; other site 685038011908 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 685038011909 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 685038011910 THF binding site; other site 685038011911 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 685038011912 substrate binding site [chemical binding]; other site 685038011913 THF binding site; other site 685038011914 zinc-binding site [ion binding]; other site 685038011915 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 685038011916 tetramer interface [polypeptide binding]; other site 685038011917 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 685038011918 active site 685038011919 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 685038011920 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 685038011921 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 685038011922 active site turn [active] 685038011923 phosphorylation site [posttranslational modification] 685038011924 transketolase; Reviewed; Region: PRK12753 685038011925 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 685038011926 TPP-binding site [chemical binding]; other site 685038011927 dimer interface [polypeptide binding]; other site 685038011928 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 685038011929 PYR/PP interface [polypeptide binding]; other site 685038011930 dimer interface [polypeptide binding]; other site 685038011931 TPP binding site [chemical binding]; other site 685038011932 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 685038011933 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 685038011934 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 685038011935 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 685038011936 putative active site [active] 685038011937 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 685038011938 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685038011939 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 685038011940 dimerization interface [polypeptide binding]; other site 685038011941 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 685038011942 Na binding site [ion binding]; other site 685038011943 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl18951 685038011944 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 685038011945 putative substrate binding site [chemical binding]; other site 685038011946 nucleotide binding site [chemical binding]; other site 685038011947 nucleotide binding site [chemical binding]; other site 685038011948 homodimer interface [polypeptide binding]; other site 685038011949 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 685038011950 CoA binding domain; Region: CoA_binding; pfam02629 685038011951 CoA-ligase; Region: Ligase_CoA; pfam00549 685038011952 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 685038011953 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 685038011954 catalytic triad [active] 685038011955 conserved cis-peptide bond; other site 685038011956 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 685038011957 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 685038011958 uridine phosphorylase; Provisional; Region: PRK11178 685038011959 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 685038011960 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 685038011961 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 685038011962 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 685038011963 active site 685038011964 intersubunit interface [polypeptide binding]; other site 685038011965 catalytic residue [active] 685038011966 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 685038011967 Transcriptional regulator [Transcription]; Region: IclR; COG1414 685038011968 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 685038011969 Bacterial transcriptional regulator; Region: IclR; pfam01614 685038011970 DNA recombination protein RmuC; Provisional; Region: PRK10361 685038011971 RmuC family; Region: RmuC; pfam02646 685038011972 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 685038011973 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685038011974 S-adenosylmethionine binding site [chemical binding]; other site 685038011975 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 685038011976 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 685038011977 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 685038011978 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 685038011979 sec-independent translocase; Provisional; Region: PRK01770 685038011980 sec-independent translocase; Provisional; Region: tatB; PRK00404 685038011981 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 685038011982 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 685038011983 active site 685038011984 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 685038011985 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 685038011986 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 685038011987 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 685038011988 FMN reductase; Validated; Region: fre; PRK08051 685038011989 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 685038011990 FAD binding pocket [chemical binding]; other site 685038011991 FAD binding motif [chemical binding]; other site 685038011992 phosphate binding motif [ion binding]; other site 685038011993 beta-alpha-beta structure motif; other site 685038011994 NAD binding pocket [chemical binding]; other site 685038011995 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 685038011996 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 685038011997 dimer interface [polypeptide binding]; other site 685038011998 active site 685038011999 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 685038012000 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 685038012001 substrate binding site [chemical binding]; other site 685038012002 oxyanion hole (OAH) forming residues; other site 685038012003 trimer interface [polypeptide binding]; other site 685038012004 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 685038012005 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 685038012006 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 685038012007 proline dipeptidase; Provisional; Region: PRK13607 685038012008 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 685038012009 active site 685038012010 hypothetical protein; Provisional; Region: PRK11568 685038012011 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 685038012012 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 685038012013 potassium transporter; Provisional; Region: PRK10750 685038012014 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 685038012015 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 685038012016 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 685038012017 Walker A motif; other site 685038012018 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 685038012019 GTP binding site; other site 685038012020 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 685038012021 serine/threonine protein kinase; Provisional; Region: PRK11768 685038012022 Phosphotransferase enzyme family; Region: APH; pfam01636 685038012023 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 685038012024 catalytic residues [active] 685038012025 hinge region; other site 685038012026 alpha helical domain; other site 685038012027 hypothetical protein; Provisional; Region: PRK11367 685038012028 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 685038012029 putative acyl-acceptor binding pocket; other site 685038012030 DNA polymerase I; Provisional; Region: PRK05755 685038012031 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 685038012032 active site 685038012033 metal binding site 1 [ion binding]; metal-binding site 685038012034 putative 5' ssDNA interaction site; other site 685038012035 metal binding site 3; metal-binding site 685038012036 metal binding site 2 [ion binding]; metal-binding site 685038012037 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 685038012038 putative DNA binding site [nucleotide binding]; other site 685038012039 putative metal binding site [ion binding]; other site 685038012040 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 685038012041 active site 685038012042 catalytic site [active] 685038012043 substrate binding site [chemical binding]; other site 685038012044 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 685038012045 active site 685038012046 DNA binding site [nucleotide binding] 685038012047 catalytic site [active] 685038012048 Predicted GTPase [General function prediction only]; Region: COG0218 685038012049 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 685038012050 G1 box; other site 685038012051 GTP/Mg2+ binding site [chemical binding]; other site 685038012052 Switch I region; other site 685038012053 G2 box; other site 685038012054 G3 box; other site 685038012055 Switch II region; other site 685038012056 G4 box; other site 685038012057 G5 box; other site 685038012058 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078 685038012059 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 685038012060 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 685038012061 FeS/SAM binding site; other site 685038012062 HemN C-terminal domain; Region: HemN_C; pfam06969 685038012063 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 685038012064 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685038012065 active site 685038012066 phosphorylation site [posttranslational modification] 685038012067 intermolecular recognition site; other site 685038012068 dimerization interface [polypeptide binding]; other site 685038012069 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685038012070 Walker A motif; other site 685038012071 ATP binding site [chemical binding]; other site 685038012072 Walker B motif; other site 685038012073 arginine finger; other site 685038012074 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 685038012075 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 685038012076 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 685038012077 putative active site [active] 685038012078 heme pocket [chemical binding]; other site 685038012079 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 685038012080 dimer interface [polypeptide binding]; other site 685038012081 phosphorylation site [posttranslational modification] 685038012082 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685038012083 ATP binding site [chemical binding]; other site 685038012084 Mg2+ binding site [ion binding]; other site 685038012085 G-X-G motif; other site 685038012086 glutamine synthetase; Provisional; Region: glnA; PRK09469 685038012087 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 685038012088 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 685038012089 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 685038012090 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 685038012091 G1 box; other site 685038012092 putative GEF interaction site [polypeptide binding]; other site 685038012093 GTP/Mg2+ binding site [chemical binding]; other site 685038012094 Switch I region; other site 685038012095 G2 box; other site 685038012096 G3 box; other site 685038012097 Switch II region; other site 685038012098 G4 box; other site 685038012099 G5 box; other site 685038012100 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 685038012101 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 685038012102 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 685038012103 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 685038012104 active site 685038012105 motif I; other site 685038012106 motif II; other site 685038012107 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 685038012108 FeS/SAM binding site; other site 685038012109 coproporphyrinogen III oxidase; Validated; Region: PRK08208 685038012110 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 685038012111 FeS/SAM binding site; other site 685038012112 HemN C-terminal domain; Region: HemN_C; pfam06969 685038012113 Sulfatase; Region: Sulfatase; cl19157 685038012114 ATP-grasp domain; Region: ATP-grasp_4; cl17255 685038012115 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 685038012116 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 685038012117 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 685038012118 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 685038012119 substrate binding site [chemical binding]; other site 685038012120 ATP binding site [chemical binding]; other site 685038012121 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 685038012122 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 685038012123 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 685038012124 Class I aldolases; Region: Aldolase_Class_I; cl17187 685038012125 catalytic residue [active] 685038012126 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 685038012127 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 685038012128 NAD(P) binding site [chemical binding]; other site 685038012129 benzoate transport; Region: 2A0115; TIGR00895 685038012130 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038012131 putative substrate translocation pore; other site 685038012132 shikimate transporter; Provisional; Region: PRK09952 685038012133 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038012134 putative substrate translocation pore; other site 685038012135 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 685038012136 active site 685038012137 catalytic residues [active] 685038012138 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 685038012139 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 685038012140 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 685038012141 motif II; other site 685038012142 hypothetical protein; Reviewed; Region: PRK01637 685038012143 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 685038012144 putative active site [active] 685038012145 dimerization interface [polypeptide binding]; other site 685038012146 putative tRNAtyr binding site [nucleotide binding]; other site 685038012147 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 685038012148 Coenzyme A binding pocket [chemical binding]; other site 685038012149 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 685038012150 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 685038012151 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 685038012152 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 685038012153 non-specific DNA binding site [nucleotide binding]; other site 685038012154 salt bridge; other site 685038012155 sequence-specific DNA binding site [nucleotide binding]; other site 685038012156 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 685038012157 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 685038012158 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 685038012159 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 685038012160 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 685038012161 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 685038012162 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 685038012163 molybdopterin cofactor binding site; other site 685038012164 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 685038012165 molybdopterin cofactor binding site; other site 685038012166 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 685038012167 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 685038012168 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 685038012169 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 685038012170 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 685038012171 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 685038012172 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 685038012173 intersubunit interface [polypeptide binding]; other site 685038012174 active site 685038012175 Zn2+ binding site [ion binding]; other site 685038012176 L-rhamnose isomerase; Provisional; Region: PRK01076 685038012177 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 685038012178 N- and C-terminal domain interface [polypeptide binding]; other site 685038012179 active site 685038012180 putative catalytic site [active] 685038012181 metal binding site [ion binding]; metal-binding site 685038012182 ATP binding site [chemical binding]; other site 685038012183 rhamnulokinase; Provisional; Region: rhaB; PRK10640 685038012184 carbohydrate binding site [chemical binding]; other site 685038012185 transcriptional activator RhaS; Provisional; Region: PRK13503 685038012186 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 685038012187 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 685038012188 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 685038012189 transcriptional activator RhaR; Provisional; Region: PRK13500 685038012190 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 685038012191 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 685038012192 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 685038012193 Sugar transport protein; Region: Sugar_transport; cl19288 685038012194 superoxide dismutase; Provisional; Region: PRK10925 685038012195 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 685038012196 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 685038012197 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 685038012198 2-keto-3-deoxygluconate permease; Region: KdgT; cl14653 685038012199 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 685038012200 MOSC domain; Region: MOSC; pfam03473 685038012201 3-alpha domain; Region: 3-alpha; pfam03475 685038012202 two-component sensor protein; Provisional; Region: cpxA; PRK09470 685038012203 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 685038012204 dimerization interface [polypeptide binding]; other site 685038012205 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 685038012206 dimer interface [polypeptide binding]; other site 685038012207 phosphorylation site [posttranslational modification] 685038012208 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685038012209 ATP binding site [chemical binding]; other site 685038012210 Mg2+ binding site [ion binding]; other site 685038012211 G-X-G motif; other site 685038012212 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 685038012213 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685038012214 active site 685038012215 intermolecular recognition site; other site 685038012216 dimerization interface [polypeptide binding]; other site 685038012217 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 685038012218 DNA binding site [nucleotide binding] 685038012219 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 685038012220 dimer interface [polypeptide binding]; other site 685038012221 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 685038012222 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 685038012223 active site 685038012224 ADP/pyrophosphate binding site [chemical binding]; other site 685038012225 dimerization interface [polypeptide binding]; other site 685038012226 allosteric effector site; other site 685038012227 fructose-1,6-bisphosphate binding site; other site 685038012228 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 685038012229 substrate binding pocket [chemical binding]; other site 685038012230 membrane-bound complex binding site; other site 685038012231 hinge residues; other site 685038012232 CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672 685038012233 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 685038012234 substrate binding site [chemical binding]; other site 685038012235 dimer interface [polypeptide binding]; other site 685038012236 catalytic triad [active] 685038012237 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 685038012238 Predicted membrane protein [Function unknown]; Region: COG3152 685038012239 hypothetical protein; Provisional; Region: PRK09981 685038012240 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 685038012241 Ligand Binding Site [chemical binding]; other site 685038012242 ferredoxin-NADP reductase; Provisional; Region: PRK10926 685038012243 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 685038012244 FAD binding pocket [chemical binding]; other site 685038012245 FAD binding motif [chemical binding]; other site 685038012246 phosphate binding motif [ion binding]; other site 685038012247 beta-alpha-beta structure motif; other site 685038012248 NAD binding pocket [chemical binding]; other site 685038012249 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 685038012250 putative active site [active] 685038012251 glycerol kinase; Provisional; Region: glpK; PRK00047 685038012252 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 685038012253 N- and C-terminal domain interface [polypeptide binding]; other site 685038012254 active site 685038012255 MgATP binding site [chemical binding]; other site 685038012256 catalytic site [active] 685038012257 metal binding site [ion binding]; metal-binding site 685038012258 glycerol binding site [chemical binding]; other site 685038012259 homotetramer interface [polypeptide binding]; other site 685038012260 homodimer interface [polypeptide binding]; other site 685038012261 FBP binding site [chemical binding]; other site 685038012262 protein IIAGlc interface [polypeptide binding]; other site 685038012263 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 685038012264 amphipathic channel; other site 685038012265 Asn-Pro-Ala signature motifs; other site 685038012266 septal ring assembly protein ZapB; Provisional; Region: PRK15422 685038012267 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 685038012268 1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Region: PT_UbiA_UBIAD1; cd13962 685038012269 putative active site [active] 685038012270 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 685038012271 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685038012272 Walker A motif; other site 685038012273 ATP binding site [chemical binding]; other site 685038012274 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 685038012275 Walker B motif; other site 685038012276 arginine finger; other site 685038012277 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 685038012278 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 685038012279 active site 685038012280 HslU subunit interaction site [polypeptide binding]; other site 685038012281 essential cell division protein FtsN; Provisional; Region: PRK10927 685038012282 Sporulation related domain; Region: SPOR; pfam05036 685038012283 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 685038012284 DNA binding site [nucleotide binding] 685038012285 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 685038012286 domain linker motif; other site 685038012287 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 685038012288 dimerization interface [polypeptide binding]; other site 685038012289 ligand binding site [chemical binding]; other site 685038012290 primosome assembly protein PriA; Validated; Region: PRK05580 685038012291 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 685038012292 ATP binding site [chemical binding]; other site 685038012293 putative Mg++ binding site [ion binding]; other site 685038012294 helicase superfamily c-terminal domain; Region: HELICc; smart00490 685038012295 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 685038012296 hypothetical protein; Provisional; Region: PRK10030 685038012297 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 685038012298 dimerization interface [polypeptide binding]; other site 685038012299 DNA binding site [nucleotide binding] 685038012300 corepressor binding sites; other site 685038012301 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 685038012302 homodimer interface [polypeptide binding]; other site 685038012303 substrate-cofactor binding pocket; other site 685038012304 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685038012305 catalytic residue [active] 685038012306 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 685038012307 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 685038012308 putative catalytic residues [active] 685038012309 putative nucleotide binding site [chemical binding]; other site 685038012310 putative aspartate binding site [chemical binding]; other site 685038012311 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 685038012312 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 685038012313 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 685038012314 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 685038012315 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 685038012316 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 685038012317 active site 685038012318 metal binding site [ion binding]; metal-binding site 685038012319 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 685038012320 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 685038012321 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 685038012322 active site 685038012323 metal binding site [ion binding]; metal-binding site 685038012324 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 685038012325 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 685038012326 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 685038012327 active site 685038012328 metal binding site [ion binding]; metal-binding site 685038012329 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 685038012330 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 685038012331 FAD binding site [chemical binding]; other site 685038012332 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 685038012333 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 685038012334 heme binding site [chemical binding]; other site 685038012335 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 685038012336 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 685038012337 EamA-like transporter family; Region: EamA; pfam00892 685038012338 EamA-like transporter family; Region: EamA; pfam00892 685038012339 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738 685038012340 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 685038012341 dimer interface [polypeptide binding]; other site 685038012342 active site 685038012343 metal binding site [ion binding]; metal-binding site 685038012344 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 685038012345 active site 685038012346 intersubunit interactions; other site 685038012347 catalytic residue [active] 685038012348 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 685038012349 dimerization domain swap beta strand [polypeptide binding]; other site 685038012350 regulatory protein interface [polypeptide binding]; other site 685038012351 active site 685038012352 regulatory phosphorylation site [posttranslational modification]; other site 685038012353 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 685038012354 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 685038012355 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 685038012356 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 685038012357 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 685038012358 active site 685038012359 phosphorylation site [posttranslational modification] 685038012360 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 685038012361 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 685038012362 active site 685038012363 P-loop; other site 685038012364 phosphorylation site [posttranslational modification] 685038012365 putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983 685038012366 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 685038012367 dimer interface [polypeptide binding]; other site 685038012368 active site 685038012369 glycine loop; other site 685038012370 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 685038012371 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 685038012372 FeS/SAM binding site; other site 685038012373 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 685038012374 active site 685038012375 P-loop; other site 685038012376 phosphorylation site [posttranslational modification] 685038012377 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 685038012378 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 685038012379 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 685038012380 hypothetical protein; Provisional; Region: PRK10649 685038012381 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 685038012382 Sulfatase; Region: Sulfatase; pfam00884 685038012383 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 685038012384 acetylornithine deacetylase (ArgE); Region: AcOrn-deacetyl; TIGR01892 685038012385 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 685038012386 metal binding site [ion binding]; metal-binding site 685038012387 putative dimer interface [polypeptide binding]; other site 685038012388 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 685038012389 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 685038012390 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl19935 685038012391 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 685038012392 nucleotide binding site [chemical binding]; other site 685038012393 N-acetyl-L-glutamate binding site [chemical binding]; other site 685038012394 argininosuccinate lyase; Provisional; Region: PRK04833 685038012395 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 685038012396 active sites [active] 685038012397 tetramer interface [polypeptide binding]; other site 685038012398 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 685038012399 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 685038012400 putative active site pocket [active] 685038012401 putative metal binding site [ion binding]; other site 685038012402 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038012403 D-galactonate transporter; Region: 2A0114; TIGR00893 685038012404 putative substrate translocation pore; other site 685038012405 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 685038012406 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685038012407 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 685038012408 dimerization interface [polypeptide binding]; other site 685038012409 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 685038012410 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 685038012411 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 685038012412 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 685038012413 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 685038012414 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 685038012415 metal binding site [ion binding]; metal-binding site 685038012416 putative dimer interface [polypeptide binding]; other site 685038012417 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038012418 metabolite-proton symporter; Region: 2A0106; TIGR00883 685038012419 putative substrate translocation pore; other site 685038012420 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 685038012421 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685038012422 hypothetical protein; Provisional; Region: PRK11056 685038012423 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 685038012424 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685038012425 S-adenosylmethionine binding site [chemical binding]; other site 685038012426 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 685038012427 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 685038012428 N-terminal plug; other site 685038012429 ligand-binding site [chemical binding]; other site 685038012430 glutamate racemase; Provisional; Region: PRK00865 685038012431 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 685038012432 FAD binding domain; Region: FAD_binding_4; pfam01565 685038012433 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 685038012434 Biotin operon repressor [Transcription]; Region: BirA; COG1654 685038012435 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 685038012436 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 685038012437 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 685038012438 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 685038012439 ATP-binding site [chemical binding]; other site 685038012440 CoA-binding site [chemical binding]; other site 685038012441 Mg2+-binding site [ion binding]; other site 685038012442 elongation factor Tu; Reviewed; Region: PRK00049 685038012443 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 685038012444 G1 box; other site 685038012445 GEF interaction site [polypeptide binding]; other site 685038012446 GTP/Mg2+ binding site [chemical binding]; other site 685038012447 Switch I region; other site 685038012448 G2 box; other site 685038012449 G3 box; other site 685038012450 Switch II region; other site 685038012451 G4 box; other site 685038012452 G5 box; other site 685038012453 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 685038012454 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 685038012455 Antibiotic Binding Site [chemical binding]; other site 685038012456 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 685038012457 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 685038012458 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 685038012459 putative homodimer interface [polypeptide binding]; other site 685038012460 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 685038012461 heterodimer interface [polypeptide binding]; other site 685038012462 homodimer interface [polypeptide binding]; other site 685038012463 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 685038012464 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 685038012465 23S rRNA interface [nucleotide binding]; other site 685038012466 L7/L12 interface [polypeptide binding]; other site 685038012467 putative thiostrepton binding site; other site 685038012468 L25 interface [polypeptide binding]; other site 685038012469 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 685038012470 mRNA/rRNA interface [nucleotide binding]; other site 685038012471 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 685038012472 23S rRNA interface [nucleotide binding]; other site 685038012473 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 685038012474 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 685038012475 core dimer interface [polypeptide binding]; other site 685038012476 peripheral dimer interface [polypeptide binding]; other site 685038012477 L10 interface [polypeptide binding]; other site 685038012478 L11 interface [polypeptide binding]; other site 685038012479 putative EF-Tu interaction site [polypeptide binding]; other site 685038012480 putative EF-G interaction site [polypeptide binding]; other site 685038012481 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 685038012482 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 685038012483 RPB12 interaction site [polypeptide binding]; other site 685038012484 RPB1 interaction site [polypeptide binding]; other site 685038012485 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 685038012486 RPB10 interaction site [polypeptide binding]; other site 685038012487 RPB11 interaction site [polypeptide binding]; other site 685038012488 RPB3 interaction site [polypeptide binding]; other site 685038012489 Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609 685038012490 beta and beta' interface [polypeptide binding]; other site 685038012491 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 685038012492 beta' and sigma factor interface [polypeptide binding]; other site 685038012493 Zn-binding [ion binding]; other site 685038012494 active site region [active] 685038012495 catalytic site [active] 685038012496 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 685038012497 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 685038012498 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 685038012499 G-loop; other site 685038012500 DNA binding site [nucleotide binding] 685038012501 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 685038012502 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 685038012503 FeS/SAM binding site; other site 685038012504 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 685038012505 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 685038012506 ThiS interaction site; other site 685038012507 putative active site [active] 685038012508 tetramer interface [polypeptide binding]; other site 685038012509 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 685038012510 thiS-thiF/thiG interaction site; other site 685038012511 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 685038012512 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 685038012513 ATP binding site [chemical binding]; other site 685038012514 substrate interface [chemical binding]; other site 685038012515 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 685038012516 thiamine phosphate binding site [chemical binding]; other site 685038012517 active site 685038012518 pyrophosphate binding site [ion binding]; other site 685038012519 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 685038012520 ThiC-associated domain; Region: ThiC-associated; pfam13667 685038012521 ThiC family; Region: ThiC; pfam01964 685038012522 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 685038012523 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 685038012524 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 685038012525 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 685038012526 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 685038012527 putative NADH binding site [chemical binding]; other site 685038012528 putative active site [active] 685038012529 nudix motif; other site 685038012530 putative metal binding site [ion binding]; other site 685038012531 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 685038012532 substrate binding site [chemical binding]; other site 685038012533 active site 685038012534 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 685038012535 Active_site [active] 685038012536 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 685038012537 histone-like DNA-binding protein HU; Region: HU; cd13831 685038012538 dimer interface [polypeptide binding]; other site 685038012539 DNA binding site [nucleotide binding] 685038012540 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 685038012541 zinc resistance protein; Provisional; Region: zraP; PRK11546 685038012542 dimer interface [polypeptide binding]; other site 685038012543 sensor protein ZraS; Provisional; Region: PRK10364 685038012544 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 685038012545 dimer interface [polypeptide binding]; other site 685038012546 phosphorylation site [posttranslational modification] 685038012547 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685038012548 ATP binding site [chemical binding]; other site 685038012549 Mg2+ binding site [ion binding]; other site 685038012550 G-X-G motif; other site 685038012551 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 685038012552 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685038012553 active site 685038012554 phosphorylation site [posttranslational modification] 685038012555 intermolecular recognition site; other site 685038012556 dimerization interface [polypeptide binding]; other site 685038012557 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685038012558 Walker A motif; other site 685038012559 ATP binding site [chemical binding]; other site 685038012560 Walker B motif; other site 685038012561 arginine finger; other site 685038012562 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 685038012563 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 685038012564 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 685038012565 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 685038012566 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 685038012567 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 685038012568 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 685038012569 purine monophosphate binding site [chemical binding]; other site 685038012570 dimer interface [polypeptide binding]; other site 685038012571 putative catalytic residues [active] 685038012572 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 685038012573 hypothetical protein; Provisional; Region: PRK10039 685038012574 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 685038012575 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 685038012576 Coenzyme A binding pocket [chemical binding]; other site 685038012577 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 685038012578 proposed active site lysine [active] 685038012579 conserved cys residue [active] 685038012580 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 685038012581 active site 685038012582 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 685038012583 tetramer interface [polypeptide binding]; other site 685038012584 active site 685038012585 Mg2+/Mn2+ binding site [ion binding]; other site 685038012586 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 685038012587 transcriptional repressor IclR; Provisional; Region: PRK11569 685038012588 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 685038012589 Bacterial transcriptional regulator; Region: IclR; pfam01614 685038012590 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 685038012591 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 685038012592 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 685038012593 substrate binding pocket [chemical binding]; other site 685038012594 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 685038012595 B12 binding site [chemical binding]; other site 685038012596 cobalt ligand [ion binding]; other site 685038012597 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 685038012598 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 685038012599 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 685038012600 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 685038012601 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 685038012602 active site pocket [active] 685038012603 oxyanion hole [active] 685038012604 catalytic triad [active] 685038012605 active site nucleophile [active] 685038012606 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 685038012607 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 685038012608 putative NAD(P) binding site [chemical binding]; other site 685038012609 catalytic Zn binding site [ion binding]; other site 685038012610 PTS system, mannose/fructose/sorbose family, IID component; Region: EIID-AGA; TIGR00828 685038012611 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 685038012612 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 685038012613 active site 685038012614 phosphorylation site [posttranslational modification] 685038012615 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 685038012616 active pocket/dimerization site; other site 685038012617 active site 685038012618 phosphorylation site [posttranslational modification] 685038012619 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 685038012620 classical (c) SDRs; Region: SDR_c; cd05233 685038012621 NAD(P) binding site [chemical binding]; other site 685038012622 active site 685038012623 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 685038012624 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 685038012625 putative DNA binding site [nucleotide binding]; other site 685038012626 putative Zn2+ binding site [ion binding]; other site 685038012627 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 685038012628 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 685038012629 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 685038012630 RNA binding surface [nucleotide binding]; other site 685038012631 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 685038012632 probable active site [active] 685038012633 hypothetical protein; Provisional; Region: PRK10515 685038012634 aspartate kinase III; Validated; Region: PRK09084 685038012635 AAK_AKiii-LysC-EC: Amino Acid Kinase Superfamily (AAK), AKiii-LysC-EC: this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKIII. AKIII is a monofunctional class enzyme (LysC) found in some...; Region: AAK_AKiii-LysC-EC; cd04258 685038012636 nucleotide binding site [chemical binding]; other site 685038012637 putative catalytic residues [active] 685038012638 aspartate binding site [chemical binding]; other site 685038012639 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 685038012640 lysine allosteric regulatory site; other site 685038012641 dimer interface [polypeptide binding]; other site 685038012642 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 685038012643 dimer interface [polypeptide binding]; other site 685038012644 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 685038012645 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 685038012646 active site 685038012647 dimer interface [polypeptide binding]; other site 685038012648 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 685038012649 dimer interface [polypeptide binding]; other site 685038012650 active site 685038012651 Exopolysaccharide production protein YjbE; Region: YjbE; pfam11106 685038012652 Group 4 capsule polysaccharide formation lipoprotein gfcB; Region: Cap_synth_GfcB; pfam11102 685038012653 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 685038012654 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 685038012655 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 685038012656 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 685038012657 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 685038012658 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685038012659 dimer interface [polypeptide binding]; other site 685038012660 conserved gate region; other site 685038012661 putative PBP binding loops; other site 685038012662 ABC-ATPase subunit interface; other site 685038012663 maltose transporter membrane protein; Provisional; Region: malF; PRK10999 685038012664 Maltose transport system permease protein MalF P2 domain; Region: MalF_P2; pfam14785 685038012665 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685038012666 dimer interface [polypeptide binding]; other site 685038012667 conserved gate region; other site 685038012668 putative PBP binding loops; other site 685038012669 ABC-ATPase subunit interface; other site 685038012670 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 685038012671 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 685038012672 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 685038012673 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 685038012674 Walker A/P-loop; other site 685038012675 ATP binding site [chemical binding]; other site 685038012676 Q-loop/lid; other site 685038012677 ABC transporter signature motif; other site 685038012678 Walker B; other site 685038012679 D-loop; other site 685038012680 H-loop/switch region; other site 685038012681 TOBE domain; Region: TOBE_2; pfam08402 685038012682 maltoporin; Provisional; Region: lamB; PRK09360 685038012683 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 685038012684 trimer interface; other site 685038012685 sugar binding site [chemical binding]; other site 685038012686 maltose regulon periplasmic protein; Provisional; Region: PRK10564 685038012687 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 685038012688 4-Hydroxybenzoate polyprenyltransferase; Region: PT_UbiA_COQ2; cd13959 685038012689 putative active site [active] 685038012690 Glycerol-3-phosphate O-acyltransferase [Lipid metabolism]; Region: PlsB; COG2937 685038012691 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 685038012692 putative acyl-acceptor binding pocket; other site 685038012693 Integral membrane diacylglycerol kinase; Region: DAGK_IM; cd14264 685038012694 putative active site [active] 685038012695 trimer interface [polypeptide binding]; other site 685038012696 putative active site [active] 685038012697 Zn binding site [ion binding]; other site 685038012698 LexA repressor; Validated; Region: PRK00215 685038012699 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 685038012700 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 685038012701 Catalytic site [active] 685038012702 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 685038012703 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 685038012704 hypothetical protein; Provisional; Region: PRK10428 685038012705 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 685038012706 metal binding site 2 [ion binding]; metal-binding site 685038012707 putative DNA binding helix; other site 685038012708 metal binding site 1 [ion binding]; metal-binding site 685038012709 dimer interface [polypeptide binding]; other site 685038012710 structural Zn2+ binding site [ion binding]; other site 685038012711 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 685038012712 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 685038012713 FMN binding site [chemical binding]; other site 685038012714 active site 685038012715 catalytic residues [active] 685038012716 substrate binding site [chemical binding]; other site 685038012717 phage shock protein G; Reviewed; Region: pspG; PRK09459 685038012718 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 685038012719 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 685038012720 NADP binding site [chemical binding]; other site 685038012721 dimer interface [polypeptide binding]; other site 685038012722 replicative DNA helicase; Provisional; Region: PRK08006 685038012723 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 685038012724 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 685038012725 Walker A motif; other site 685038012726 ATP binding site [chemical binding]; other site 685038012727 Walker B motif; other site 685038012728 DNA binding loops [nucleotide binding] 685038012729 alanine racemase; Reviewed; Region: alr; PRK00053 685038012730 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 685038012731 active site 685038012732 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 685038012733 substrate binding site [chemical binding]; other site 685038012734 catalytic residues [active] 685038012735 dimer interface [polypeptide binding]; other site 685038012736 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 685038012737 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 685038012738 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685038012739 homodimer interface [polypeptide binding]; other site 685038012740 catalytic residue [active] 685038012741 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 685038012742 Der GTPase activator (YihI); Region: YihI; cl01172 685038012743 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 685038012744 TPP-binding site [chemical binding]; other site 685038012745 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 685038012746 dimer interface [polypeptide binding]; other site 685038012747 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 685038012748 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 685038012749 E3 interaction surface; other site 685038012750 lipoyl attachment site [posttranslational modification]; other site 685038012751 e3 binding domain; Region: E3_binding; pfam02817 685038012752 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 685038012753 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 685038012754 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 685038012755 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 685038012756 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 685038012757 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 685038012758 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 685038012759 CoA-ligase; Region: Ligase_CoA; pfam00549 685038012760 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 685038012761 CoA binding domain; Region: CoA_binding; smart00881 685038012762 CoA-ligase; Region: Ligase_CoA; pfam00549 685038012763 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 685038012764 anion transporter; Region: dass; TIGR00785 685038012765 transmembrane helices; other site 685038012766 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 685038012767 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 685038012768 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685038012769 active site 685038012770 phosphorylation site [posttranslational modification] 685038012771 intermolecular recognition site; other site 685038012772 dimerization interface [polypeptide binding]; other site 685038012773 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685038012774 Walker A motif; other site 685038012775 ATP binding site [chemical binding]; other site 685038012776 Walker B motif; other site 685038012777 arginine finger; other site 685038012778 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 685038012779 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 685038012780 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 685038012781 dimer interface [polypeptide binding]; other site 685038012782 phosphorylation site [posttranslational modification] 685038012783 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685038012784 ATP binding site [chemical binding]; other site 685038012785 Mg2+ binding site [ion binding]; other site 685038012786 G-X-G motif; other site 685038012787 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 685038012788 active site 685038012789 motif I; other site 685038012790 motif II; other site 685038012791 secondary thiamine-phosphate synthase enzyme; Region: TIGR00149_YjbQ 685038012792 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 685038012793 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 685038012794 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 685038012795 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 685038012796 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 685038012797 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 685038012798 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 685038012799 dimer interface [polypeptide binding]; other site 685038012800 ssDNA binding site [nucleotide binding]; other site 685038012801 tetramer (dimer of dimers) interface [polypeptide binding]; other site 685038012802 putative single-stranded DNA-binding protein; Region: PHA01740 685038012803 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 685038012804 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 685038012805 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 685038012806 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 685038012807 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 685038012808 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 685038012809 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 685038012810 DNA binding residues [nucleotide binding] 685038012811 dimer interface [polypeptide binding]; other site 685038012812 [2Fe-2S] cluster binding site [ion binding]; other site 685038012813 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 685038012814 Sulfate transporter family; Region: Sulfate_transp; cl19250 685038012815 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 685038012816 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 685038012817 Transcriptional regulator [Transcription]; Region: LysR; COG0583 685038012818 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685038012819 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 685038012820 putative dimerization interface [polypeptide binding]; other site 685038012821 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 685038012822 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 685038012823 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 685038012824 Na binding site [ion binding]; other site 685038012825 Predicted membrane protein [Function unknown]; Region: COG3162 685038012826 acetyl-CoA synthetase; Provisional; Region: PRK00174 685038012827 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 685038012828 active site 685038012829 CoA binding site [chemical binding]; other site 685038012830 acyl-activating enzyme (AAE) consensus motif; other site 685038012831 AMP binding site [chemical binding]; other site 685038012832 acetate binding site [chemical binding]; other site 685038012833 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 685038012834 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 685038012835 Cytochrome c7; Region: Cytochrome_C7; cl19206 685038012836 Cytochrome c3; Region: Cytochrom_c3_2; pfam14537 685038012837 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 685038012838 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 685038012839 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 685038012840 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 685038012841 heme lyase subunit NrfE; Provisional; Region: PRK10369 685038012842 formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144 685038012843 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 685038012844 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 685038012845 binding surface 685038012846 TPR motif; other site 685038012847 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 685038012848 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 685038012849 Sel1-like repeats; Region: SEL1; smart00671 685038012850 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 685038012851 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 685038012852 Walker A/P-loop; other site 685038012853 ATP binding site [chemical binding]; other site 685038012854 Q-loop/lid; other site 685038012855 ABC transporter signature motif; other site 685038012856 Walker B; other site 685038012857 D-loop; other site 685038012858 H-loop/switch region; other site 685038012859 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 685038012860 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 685038012861 Walker A/P-loop; other site 685038012862 ATP binding site [chemical binding]; other site 685038012863 Q-loop/lid; other site 685038012864 ABC transporter signature motif; other site 685038012865 Walker B; other site 685038012866 D-loop; other site 685038012867 H-loop/switch region; other site 685038012868 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 685038012869 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 685038012870 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685038012871 dimer interface [polypeptide binding]; other site 685038012872 conserved gate region; other site 685038012873 putative PBP binding loops; other site 685038012874 ABC-ATPase subunit interface; other site 685038012875 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 685038012876 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685038012877 dimer interface [polypeptide binding]; other site 685038012878 conserved gate region; other site 685038012879 putative PBP binding loops; other site 685038012880 ABC-ATPase subunit interface; other site 685038012881 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 685038012882 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 685038012883 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 685038012884 molybdopterin cofactor binding site; other site 685038012885 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 685038012886 molybdopterin cofactor binding site; other site 685038012887 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 685038012888 putative outer membrane efflux protein MdtP; Provisional; Region: PRK09915 685038012889 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 685038012890 Outer membrane efflux protein; Region: OEP; pfam02321 685038012891 multidrug efflux system protein MdtO; Provisional; Region: PRK11427 685038012892 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 685038012893 multidrug resistance protein MdtN; Provisional; Region: PRK10476 685038012894 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 685038012895 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 685038012896 HlyD family secretion protein; Region: HlyD_3; pfam13437 685038012897 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 685038012898 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 685038012899 Alkyl sulfatase dimerization; Region: Alkyl_sulf_dimr; pfam14863 685038012900 Alkyl sulfatase C-terminal; Region: Alkyl_sulf_C; pfam14864 685038012901 D-allose kinase; Provisional; Region: PRK09698 685038012902 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 685038012903 nucleotide binding site [chemical binding]; other site 685038012904 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 685038012905 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 685038012906 substrate binding site [chemical binding]; other site 685038012907 hexamer interface [polypeptide binding]; other site 685038012908 metal binding site [ion binding]; metal-binding site 685038012909 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 685038012910 TM-ABC transporter signature motif; other site 685038012911 D-allose transporter ATP-binding protein; Provisional; Region: PRK09700 685038012912 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 685038012913 Walker A/P-loop; other site 685038012914 ATP binding site [chemical binding]; other site 685038012915 Q-loop/lid; other site 685038012916 ABC transporter signature motif; other site 685038012917 Walker B; other site 685038012918 D-loop; other site 685038012919 H-loop/switch region; other site 685038012920 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 685038012921 D-allose transporter subunit; Provisional; Region: PRK09701 685038012922 Periplasmic allose-binding domain of bacterial transport systems that function as a primary receptor of active transport and chemotaxis; Region: PBP1_allose_binding; cd06320 685038012923 ligand binding site [chemical binding]; other site 685038012924 dimerization interface [polypeptide binding]; other site 685038012925 zinc binding site [ion binding]; other site 685038012926 DNA-binding transcriptional repressor RpiR; Provisional; Region: PRK11337 685038012927 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 685038012928 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 685038012929 putative active site [active] 685038012930 ribose 5-phosphate isomerase B; Region: rpiB; TIGR01120 685038012931 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 685038012932 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 685038012933 Coenzyme A binding pocket [chemical binding]; other site 685038012934 ribose 1,5-bisphosphokinase; Provisional; Region: PRK10078 685038012935 Guanylate kinase; Region: Guanylate_kin; pfam00625 685038012936 active site 685038012937 Metal-dependent hydrolase involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3454 685038012938 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 685038012939 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 685038012940 active site 685038012941 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 685038012942 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685038012943 Walker A/P-loop; other site 685038012944 ATP binding site [chemical binding]; other site 685038012945 Q-loop/lid; other site 685038012946 ABC transporter signature motif; other site 685038012947 Walker B; other site 685038012948 D-loop; other site 685038012949 H-loop/switch region; other site 685038012950 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 685038012951 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 685038012952 Walker A/P-loop; other site 685038012953 ATP binding site [chemical binding]; other site 685038012954 Q-loop/lid; other site 685038012955 ABC transporter signature motif; other site 685038012956 Walker B; other site 685038012957 D-loop; other site 685038012958 H-loop/switch region; other site 685038012959 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 685038012960 Phosphonate metabolizm protein PhnJ; Region: PhnJ; pfam06007 685038012961 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnI; COG3626 685038012962 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnH; COG3625 685038012963 Phosphonate metabolizm protein PhnG; Region: PhnG; pfam06754 685038012964 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 685038012965 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 685038012966 DNA-binding site [nucleotide binding]; DNA binding site 685038012967 UTRA domain; Region: UTRA; pfam07702 685038012968 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 685038012969 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685038012970 dimer interface [polypeptide binding]; other site 685038012971 conserved gate region; other site 685038012972 putative PBP binding loops; other site 685038012973 ABC-ATPase subunit interface; other site 685038012974 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 685038012975 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 685038012976 phosphonate/organophosphate ester transporter subunit; Provisional; Region: PRK09984 685038012977 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 685038012978 Walker A/P-loop; other site 685038012979 ATP binding site [chemical binding]; other site 685038012980 Q-loop/lid; other site 685038012981 ABC transporter signature motif; other site 685038012982 Walker B; other site 685038012983 D-loop; other site 685038012984 H-loop/switch region; other site 685038012985 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 685038012986 dimer interface [polypeptide binding]; other site 685038012987 hypothetical protein; Provisional; Region: PRK10220 685038012988 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 685038012989 PhnA protein; Region: PhnA; pfam03831 685038012990 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 685038012991 G1 box; other site 685038012992 GTP/Mg2+ binding site [chemical binding]; other site 685038012993 G2 box; other site 685038012994 Switch I region; other site 685038012995 G3 box; other site 685038012996 Switch II region; other site 685038012997 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 685038012998 G2 box; other site 685038012999 Switch I region; other site 685038013000 G3 box; other site 685038013001 Switch II region; other site 685038013002 G4 box; other site 685038013003 G5 box; other site 685038013004 Coronavirus S2 glycoprotein; Region: Corona_S2; pfam01601 685038013005 YjcZ-like protein; Region: YjcZ; pfam13990 685038013006 proline/glycine betaine transporter; Provisional; Region: PRK10642 685038013007 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038013008 putative substrate translocation pore; other site 685038013009 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 685038013010 sensor protein BasS/PmrB; Provisional; Region: PRK10755 685038013011 HAMP domain; Region: HAMP; pfam00672 685038013012 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 685038013013 dimer interface [polypeptide binding]; other site 685038013014 phosphorylation site [posttranslational modification] 685038013015 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685038013016 ATP binding site [chemical binding]; other site 685038013017 Mg2+ binding site [ion binding]; other site 685038013018 G-X-G motif; other site 685038013019 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 685038013020 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685038013021 active site 685038013022 phosphorylation site [posttranslational modification] 685038013023 intermolecular recognition site; other site 685038013024 dimerization interface [polypeptide binding]; other site 685038013025 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 685038013026 DNA binding site [nucleotide binding] 685038013027 putative metal dependent hydrolase; Provisional; Region: PRK11598 685038013028 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 685038013029 Sulfatase; Region: Sulfatase; pfam00884 685038013030 arginine:agmatin antiporter; Provisional; Region: PRK10644 685038013031 Spore germination protein; Region: Spore_permease; cl17796 685038013032 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 685038013033 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 685038013034 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 685038013035 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 685038013036 arginine decarboxylase; Provisional; Region: PRK15029 685038013037 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 685038013038 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 685038013039 homodimer interface [polypeptide binding]; other site 685038013040 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685038013041 catalytic residue [active] 685038013042 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 685038013043 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 685038013044 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 685038013045 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 685038013046 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 685038013047 alpha-galactosidase; Provisional; Region: PRK15076 685038013048 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 685038013049 NAD binding site [chemical binding]; other site 685038013050 sugar binding site [chemical binding]; other site 685038013051 divalent metal binding site [ion binding]; other site 685038013052 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 685038013053 dimer interface [polypeptide binding]; other site 685038013054 hypothetical protein; Provisional; Region: PRK09867 685038013055 fumarate hydratase FumB; Provisional; Region: PRK15391 685038013056 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 685038013057 Fumarase C-terminus; Region: Fumerase_C; pfam05683 685038013058 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 685038013059 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 685038013060 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685038013061 active site 685038013062 phosphorylation site [posttranslational modification] 685038013063 intermolecular recognition site; other site 685038013064 dimerization interface [polypeptide binding]; other site 685038013065 sensory histidine kinase DcuS; Provisional; Region: PRK11086 685038013066 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 685038013067 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 685038013068 putative active site [active] 685038013069 heme pocket [chemical binding]; other site 685038013070 Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689 685038013071 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685038013072 ATP binding site [chemical binding]; other site 685038013073 Mg2+ binding site [ion binding]; other site 685038013074 G-X-G motif; other site 685038013075 Uncharacterized conserved protein [Function unknown]; Region: COG3592 685038013076 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 685038013077 Coenzyme A binding pocket [chemical binding]; other site 685038013078 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 685038013079 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 685038013080 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 685038013081 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 685038013082 dimer interface [polypeptide binding]; other site 685038013083 putative anticodon binding site; other site 685038013084 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 685038013085 motif 1; other site 685038013086 active site 685038013087 motif 2; other site 685038013088 motif 3; other site 685038013089 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 685038013090 POT family; Region: PTR2; cl17359 685038013091 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038013092 putative substrate translocation pore; other site 685038013093 lysine decarboxylase CadA; Provisional; Region: PRK15400 685038013094 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 685038013095 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 685038013096 homodimer interface [polypeptide binding]; other site 685038013097 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685038013098 catalytic residue [active] 685038013099 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 685038013100 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 685038013101 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 685038013102 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 685038013103 DNA binding site [nucleotide binding] 685038013104 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 685038013105 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 685038013106 P-loop; other site 685038013107 Magnesium ion binding site [ion binding]; other site 685038013108 replicative DNA helicase; Region: DnaB; TIGR00665 685038013109 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 685038013110 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 685038013111 Walker A motif; other site 685038013112 ATP binding site [chemical binding]; other site 685038013113 Walker B motif; other site 685038013114 DNA binding loops [nucleotide binding] 685038013115 integrating conjugative element, PFGI_1 class, ParB family protein; Region: ICE_PFGI_1_parB; TIGR03764 685038013116 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 685038013117 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 685038013118 Protein of unknown function (DUF2857); Region: DUF2857; pfam11198 685038013119 Helix-turn-helix domain; Region: HTH_36; pfam13730 685038013120 Domain of unknown function (DUF1845); Region: DUF1845; pfam08900 685038013121 DNA topoisomerase III; Provisional; Region: PRK07726 685038013122 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 685038013123 active site 685038013124 putative interdomain interaction site [polypeptide binding]; other site 685038013125 putative metal-binding site [ion binding]; other site 685038013126 putative nucleotide binding site [chemical binding]; other site 685038013127 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 685038013128 domain I; other site 685038013129 DNA binding groove [nucleotide binding] 685038013130 phosphate binding site [ion binding]; other site 685038013131 domain II; other site 685038013132 domain III; other site 685038013133 nucleotide binding site [chemical binding]; other site 685038013134 catalytic site [active] 685038013135 domain IV; other site 685038013136 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 685038013137 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271 685038013138 Protein of unknown function (DUF3577); Region: DUF3577; pfam12101 685038013139 conjugative transfer region protein, TIGR03748 family; Region: conj_PilL 685038013140 integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759 685038013141 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 685038013142 N-acetyl-D-glucosamine binding site [chemical binding]; other site 685038013143 Protein of unknown function (DUF2859); Region: DUF2859; pfam11072 685038013144 conjugative coupling factor TraD, TOL family; Region: conj_TOL_TraD; TIGR03754 685038013145 integrating conjugative element membrane protein, PFL_4697 family; Region: conj_TIGR03747 685038013146 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 685038013147 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 685038013148 P-loop; other site 685038013149 Magnesium ion binding site [ion binding]; other site 685038013150 Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686 685038013151 Protein of unknown function (DUF3262); Region: DUF3262; pfam11660 685038013152 Protein of unknown function (DUF2976); Region: DUF2976; cl12739 685038013153 conjugative transfer region protein, TIGR03750 family; Region: conj_TIGR03750 685038013154 integrating conjugative element protein, PFL_4703 family; Region: conj_TIGR03746 685038013155 Protein of unknown function (DUF3438); Region: DUF3438; pfam11920 685038013156 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 685038013157 conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751 685038013158 conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744 685038013159 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 685038013160 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 685038013161 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 685038013162 active site 685038013163 Zn binding site [ion binding]; other site 685038013164 Protein of unknown function (DUF1525); Region: DUF1525; pfam07511 685038013165 integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756 685038013166 integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755 685038013167 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 685038013168 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 685038013169 DNA-binding site [nucleotide binding]; DNA binding site 685038013170 RNA-binding motif; other site 685038013171 Phage integrase, N-terminal; Region: Phage_int_SAM_2; pfam12834 685038013172 Integrase; Region: Integrase_1; pfam12835 685038013173 Antirestriction protein; Region: Antirestrict; pfam03230 685038013174 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 685038013175 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 685038013176 Bacterial SH3 domain; Region: SH3_3; pfam08239 685038013177 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 685038013178 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 685038013179 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 685038013180 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_1; cl12235 685038013181 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 685038013182 active site 685038013183 catalytic residues [active] 685038013184 DNA binding site [nucleotide binding] 685038013185 Int/Topo IB signature motif; other site 685038013186 putative transcriptional regulator; Provisional; Region: PRK11640 685038013187 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 685038013188 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 685038013189 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 685038013190 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 685038013191 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 685038013192 DsbD alpha interface [polypeptide binding]; other site 685038013193 catalytic residues [active] 685038013194 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 685038013195 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 685038013196 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 685038013197 Aspartase; Region: Aspartase; cd01357 685038013198 active sites [active] 685038013199 tetramer interface [polypeptide binding]; other site 685038013200 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 685038013201 putative transporter; Provisional; Region: PRK11021 685038013202 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 685038013203 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 685038013204 oligomerisation interface [polypeptide binding]; other site 685038013205 mobile loop; other site 685038013206 roof hairpin; other site 685038013207 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 685038013208 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 685038013209 ring oligomerisation interface [polypeptide binding]; other site 685038013210 ATP/Mg binding site [chemical binding]; other site 685038013211 stacking interactions; other site 685038013212 hinge regions; other site 685038013213 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 685038013214 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 685038013215 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 685038013216 FeS/SAM binding site; other site 685038013217 elongation factor P; Validated; Region: PRK00529 685038013218 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 685038013219 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 685038013220 RNA binding site [nucleotide binding]; other site 685038013221 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 685038013222 RNA binding site [nucleotide binding]; other site 685038013223 entericidin A; Provisional; Region: PRK09810 685038013224 entericidin B membrane lipoprotein; Provisional; Region: PRK10081 685038013225 multidrug efflux system protein; Provisional; Region: PRK11431 685038013226 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 685038013227 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 685038013228 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 685038013229 Iron-sulfur protein interface; other site 685038013230 proximal quinone binding site [chemical binding]; other site 685038013231 C-subunit interface; other site 685038013232 distal quinone binding site; other site 685038013233 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 685038013234 D-subunit interface [polypeptide binding]; other site 685038013235 Iron-sulfur protein interface; other site 685038013236 proximal quinone binding site [chemical binding]; other site 685038013237 distal quinone binding site [chemical binding]; other site 685038013238 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 685038013239 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 685038013240 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 685038013241 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 685038013242 L-aspartate oxidase; Provisional; Region: PRK06175 685038013243 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 685038013244 poxB regulator PoxA; Provisional; Region: PRK09350 685038013245 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 685038013246 motif 1; other site 685038013247 dimer interface [polypeptide binding]; other site 685038013248 active site 685038013249 motif 2; other site 685038013250 motif 3; other site 685038013251 inner membrane transporter YjeM; Provisional; Region: PRK15238 685038013252 putative mechanosensitive channel protein; Provisional; Region: PRK10929 685038013253 linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated...; Region: H15; cl00073 685038013254 DNA-binding site [nucleotide binding]; DNA binding site 685038013255 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 685038013256 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 685038013257 Mechanosensitive ion channel; Region: MS_channel; pfam00924 685038013258 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 685038013259 GTPase RsgA; Reviewed; Region: PRK12288 685038013260 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 685038013261 RNA binding site [nucleotide binding]; other site 685038013262 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 685038013263 GTPase/Zn-binding domain interface [polypeptide binding]; other site 685038013264 GTP/Mg2+ binding site [chemical binding]; other site 685038013265 G4 box; other site 685038013266 G5 box; other site 685038013267 G1 box; other site 685038013268 Switch I region; other site 685038013269 G2 box; other site 685038013270 G3 box; other site 685038013271 Switch II region; other site 685038013272 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 685038013273 catalytic site [active] 685038013274 putative active site [active] 685038013275 putative substrate binding site [chemical binding]; other site 685038013276 dimer interface [polypeptide binding]; other site 685038013277 epoxyqueuosine reductase; Region: TIGR00276 685038013278 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 685038013279 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 685038013280 putative carbohydrate kinase; Provisional; Region: PRK10565 685038013281 yjeF N-terminal region; Region: yjeF_nterm; TIGR00197 685038013282 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 685038013283 putative substrate binding site [chemical binding]; other site 685038013284 putative ATP binding site [chemical binding]; other site 685038013285 ADP-binding protein; Provisional; Region: PRK10646 685038013286 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 685038013287 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 685038013288 AMIN domain; Region: AMIN; pfam11741 685038013289 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 685038013290 active site 685038013291 metal binding site [ion binding]; metal-binding site 685038013292 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 685038013293 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685038013294 ATP binding site [chemical binding]; other site 685038013295 Mg2+ binding site [ion binding]; other site 685038013296 G-X-G motif; other site 685038013297 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 685038013298 ATP binding site [chemical binding]; other site 685038013299 MutL C terminal dimerization domain; Region: MutL_C; pfam08676 685038013300 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 685038013301 bacterial Hfq-like; Region: Hfq; cd01716 685038013302 hexamer interface [polypeptide binding]; other site 685038013303 Sm1 motif; other site 685038013304 RNA binding site [nucleotide binding]; other site 685038013305 Sm2 motif; other site 685038013306 GTPase HflX; Provisional; Region: PRK11058 685038013307 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 685038013308 HflX GTPase family; Region: HflX; cd01878 685038013309 G1 box; other site 685038013310 GTP/Mg2+ binding site [chemical binding]; other site 685038013311 Switch I region; other site 685038013312 G2 box; other site 685038013313 G3 box; other site 685038013314 Switch II region; other site 685038013315 G4 box; other site 685038013316 G5 box; other site 685038013317 FtsH protease regulator HflK; Provisional; Region: PRK10930 685038013318 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 685038013319 High frequency of lysogenization K (HflK) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_HflK; cd03404 685038013320 HflC protein; Region: hflC; TIGR01932 685038013321 High frequency of lysogenization C (HflC) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_HflC; cd03405 685038013322 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 685038013323 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 685038013324 GDP-binding site [chemical binding]; other site 685038013325 ACT binding site; other site 685038013326 IMP binding site; other site 685038013327 transcriptional repressor NsrR; Provisional; Region: PRK11014 685038013328 Rrf2 family protein; Region: rrf2_super; TIGR00738 685038013329 exoribonuclease R; Provisional; Region: PRK11642 685038013330 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 685038013331 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 685038013332 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 685038013333 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 685038013334 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 685038013335 RNA binding site [nucleotide binding]; other site 685038013336 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 685038013337 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 685038013338 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 685038013339 Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; cl01551 685038013340 PspA/IM30 family; Region: PspA_IM30; pfam04012 685038013341 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 685038013342 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 685038013343 Predicted membrane protein [Function unknown]; Region: COG3766 685038013344 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 685038013345 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 685038013346 Predicted integral membrane protein [Function unknown]; Region: COG5463 685038013347 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 685038013348 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 685038013349 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 685038013350 FAD binding site [chemical binding]; other site 685038013351 substrate binding site [chemical binding]; other site 685038013352 catalytic residues [active] 685038013353 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 685038013354 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 685038013355 esterase; Provisional; Region: PRK10566 685038013356 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 685038013357 transcriptional repressor UlaR; Provisional; Region: PRK13509 685038013358 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 685038013359 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 685038013360 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 685038013361 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 685038013362 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 685038013363 active site 685038013364 P-loop; other site 685038013365 phosphorylation site [posttranslational modification] 685038013366 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 685038013367 active site 685038013368 phosphorylation site [posttranslational modification] 685038013369 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 685038013370 active site 685038013371 dimer interface [polypeptide binding]; other site 685038013372 magnesium binding site [ion binding]; other site 685038013373 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 685038013374 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 685038013375 AP (apurinic/apyrimidinic) site pocket; other site 685038013376 DNA interaction; other site 685038013377 Metal-binding active site; metal-binding site 685038013378 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 685038013379 intersubunit interface [polypeptide binding]; other site 685038013380 active site 685038013381 Zn2+ binding site [ion binding]; other site 685038013382 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 685038013383 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 685038013384 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 685038013385 dimer interface [polypeptide binding]; other site 685038013386 ssDNA binding site [nucleotide binding]; other site 685038013387 tetramer (dimer of dimers) interface [polypeptide binding]; other site 685038013388 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 685038013389 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 685038013390 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 685038013391 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 685038013392 HipA N-terminal domain; Region: Couple_hipA; cl11853 685038013393 HipA-like N-terminal domain; Region: HipA_N; pfam07805 685038013394 HipA-like C-terminal domain; Region: HipA_C; pfam07804 685038013395 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038013396 D-galactonate transporter; Region: 2A0114; TIGR00893 685038013397 putative substrate translocation pore; other site 685038013398 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK06263 685038013399 L-aspartate oxidase; Provisional; Region: PRK06175 685038013400 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 685038013401 Coenzyme A transferase; Region: CoA_trans; smart00882 685038013402 Coenzyme A transferase; Region: CoA_trans; cl17247 685038013403 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 685038013404 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 685038013405 substrate binding site [chemical binding]; other site 685038013406 oxyanion hole (OAH) forming residues; other site 685038013407 trimer interface [polypeptide binding]; other site 685038013408 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 685038013409 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 685038013410 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 685038013411 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 1, classical (c) SDR; Region: BKR_1_SDR_c; cd05337 685038013412 putative NAD(P) binding site [chemical binding]; other site 685038013413 active site 685038013414 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685038013415 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685038013416 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 685038013417 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 685038013418 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 685038013419 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 685038013420 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 685038013421 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 685038013422 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 685038013423 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 685038013424 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 685038013425 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 685038013426 Hemerythrin-like domain; Region: Hr-like; cd12108 685038013427 Fe binding site [ion binding]; other site 685038013428 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 685038013429 EamA-like transporter family; Region: EamA; pfam00892 685038013430 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 685038013431 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 685038013432 NADP binding site [chemical binding]; other site 685038013433 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 685038013434 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 685038013435 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 685038013436 active site 685038013437 metal binding site [ion binding]; metal-binding site 685038013438 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 685038013439 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 685038013440 active site 685038013441 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 685038013442 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 685038013443 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 685038013444 Domain of unknown function DUF21; Region: DUF21; pfam01595 685038013445 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 685038013446 Transporter associated domain; Region: CorC_HlyC; smart01091 685038013447 methionine sulfoxide reductase A; Provisional; Region: PRK00058 685038013448 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 685038013449 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 685038013450 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 685038013451 Surface antigen; Region: Bac_surface_Ag; pfam01103 685038013452 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 685038013453 Family of unknown function (DUF490); Region: DUF490; pfam04357 685038013454 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 685038013455 putative active site pocket [active] 685038013456 dimerization interface [polypeptide binding]; other site 685038013457 putative catalytic residue [active] 685038013458 Sel1-like repeats; Region: SEL1; smart00671 685038013459 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 685038013460 Sel1-like repeats; Region: SEL1; smart00671 685038013461 Sel1-like repeats; Region: SEL1; smart00671 685038013462 Sel1-like repeats; Region: SEL1; smart00671 685038013463 Sel1-like repeats; Region: SEL1; smart00671 685038013464 Sel1-like repeats; Region: SEL1; smart00671 685038013465 Sel1-like repeats; Region: SEL1; smart00671 685038013466 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 685038013467 Sel1-like repeats; Region: SEL1; smart00671 685038013468 Sel1-like repeats; Region: SEL1; smart00671 685038013469 Sel1-like repeats; Region: SEL1; smart00671 685038013470 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 685038013471 dimer interface [polypeptide binding]; other site 685038013472 substrate binding site [chemical binding]; other site 685038013473 metal binding sites [ion binding]; metal-binding site 685038013474 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 685038013475 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 685038013476 putative ligand binding site [chemical binding]; other site 685038013477 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 685038013478 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 685038013479 Walker A/P-loop; other site 685038013480 ATP binding site [chemical binding]; other site 685038013481 Q-loop/lid; other site 685038013482 ABC transporter signature motif; other site 685038013483 Walker B; other site 685038013484 D-loop; other site 685038013485 H-loop/switch region; other site 685038013486 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 685038013487 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 685038013488 TM-ABC transporter signature motif; other site 685038013489 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 685038013490 TM-ABC transporter signature motif; other site 685038013491 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 685038013492 AMP binding site [chemical binding]; other site 685038013493 metal binding site [ion binding]; metal-binding site 685038013494 active site 685038013495 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 685038013496 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 685038013497 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 685038013498 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 685038013499 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3028 685038013500 peptidase PmbA; Provisional; Region: PRK11040 685038013501 cytochrome b562; Provisional; Region: PRK15058 685038013502 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; PRK11121 685038013503 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 685038013504 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 685038013505 ATP cone domain; Region: ATP-cone; pfam03477 685038013506 Class III ribonucleotide reductase; Region: RNR_III; cd01675 685038013507 effector binding site; other site 685038013508 active site 685038013509 Zn binding site [ion binding]; other site 685038013510 glycine loop; other site 685038013511 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 685038013512 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 685038013513 Ca binding site [ion binding]; other site 685038013514 active site 685038013515 catalytic site [active] 685038013516 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 685038013517 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 685038013518 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 685038013519 active site turn [active] 685038013520 phosphorylation site [posttranslational modification] 685038013521 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 685038013522 trehalose repressor; Provisional; Region: treR; PRK09492 685038013523 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 685038013524 DNA binding site [nucleotide binding] 685038013525 domain linker motif; other site 685038013526 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 685038013527 dimerization interface [polypeptide binding]; other site 685038013528 ligand binding site [chemical binding]; other site 685038013529 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 685038013530 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 685038013531 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 685038013532 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 685038013533 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 685038013534 motif II; other site 685038013535 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 685038013536 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 685038013537 homotrimer interaction site [polypeptide binding]; other site 685038013538 putative active site [active] 685038013539 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 685038013540 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 685038013541 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 685038013542 aspartate carbamoyltransferase; Region: asp_carb_tr; TIGR00670 685038013543 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 685038013544 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 685038013545 PyrBI operon leader peptide; Region: PyrBI_leader; pfam08052 685038013546 Arginine repressor [Transcription]; Region: ArgR; COG1438 685038013547 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 685038013548 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 685038013549 Predicted membrane protein [Function unknown]; Region: COG1288 685038013550 ornithine carbamoyltransferase; Validated; Region: PRK02102 685038013551 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 685038013552 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 685038013553 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 685038013554 putative substrate binding site [chemical binding]; other site 685038013555 nucleotide binding site [chemical binding]; other site 685038013556 nucleotide binding site [chemical binding]; other site 685038013557 homodimer interface [polypeptide binding]; other site 685038013558 arginine deiminase; Provisional; Region: PRK01388 685038013559 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 685038013560 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 685038013561 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 685038013562 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 685038013563 RNase E inhibitor protein; Provisional; Region: PRK11191 685038013564 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 685038013565 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 685038013566 Coenzyme A binding pocket [chemical binding]; other site 685038013567 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 685038013568 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 685038013569 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 685038013570 active site 685038013571 HIGH motif; other site 685038013572 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 685038013573 KMSKS motif; other site 685038013574 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 685038013575 tRNA binding surface [nucleotide binding]; other site 685038013576 anticodon binding site; other site 685038013577 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 685038013578 DNA polymerase III subunit chi; Validated; Region: PRK05728 685038013579 multifunctional aminopeptidase A; Provisional; Region: PRK00913 685038013580 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 685038013581 interface (dimer of trimers) [polypeptide binding]; other site 685038013582 Substrate-binding/catalytic site; other site 685038013583 Zn-binding sites [ion binding]; other site 685038013584 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 685038013585 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 685038013586 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 685038013587 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685038013588 Walker A motif; other site 685038013589 ATP binding site [chemical binding]; other site 685038013590 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 685038013591 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 685038013592 DNA binding site [nucleotide binding] 685038013593 domain linker motif; other site 685038013594 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 685038013595 putative dimerization interface [polypeptide binding]; other site 685038013596 putative ligand binding site [chemical binding]; other site 685038013597 gluconate transporter; Region: gntP; TIGR00791 685038013598 GntP family permease; Region: GntP_permease; pfam02447 685038013599 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 685038013600 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 685038013601 NADP binding site [chemical binding]; other site 685038013602 homodimer interface [polypeptide binding]; other site 685038013603 active site 685038013604 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 685038013605 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 685038013606 putative NAD(P) binding site [chemical binding]; other site 685038013607 catalytic Zn binding site [ion binding]; other site 685038013608 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 685038013609 AAA domain; Region: AAA_33; pfam13671 685038013610 ATP-binding site [chemical binding]; other site 685038013611 Gluconate-6-phosphate binding site [chemical binding]; other site 685038013612 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 685038013613 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 685038013614 putative NAD(P) binding site [chemical binding]; other site 685038013615 putative substrate binding site [chemical binding]; other site 685038013616 catalytic Zn binding site [ion binding]; other site 685038013617 structural Zn binding site [ion binding]; other site 685038013618 dimer interface [polypeptide binding]; other site 685038013619 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 685038013620 FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cl15270 685038013621 DNA methylase; Region: N6_N4_Mtase; pfam01555 685038013622 type III restriction-modification system StyLTI enzyme res; Provisional; Region: PRK15483 685038013623 Domain of unknown function (DUF303); Region: DUF303; pfam03629 685038013624 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 685038013625 Kelch motif; Region: Kelch_1; pfam01344 685038013626 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 685038013627 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 685038013628 Int/Topo IB signature motif; other site 685038013629 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 685038013630 Int/Topo IB signature motif; other site 685038013631 Fimbrial protein; Region: Fimbrial; cl01416 685038013632 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 685038013633 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 685038013634 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 685038013635 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 685038013636 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 685038013637 PapC N-terminal domain; Region: PapC_N; pfam13954 685038013638 Outer membrane usher protein; Region: Usher; pfam00577 685038013639 PapC C-terminal domain; Region: PapC_C; pfam13953 685038013640 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 685038013641 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 685038013642 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 685038013643 mannosyl binding site [chemical binding]; other site 685038013644 Fimbrial protein; Region: Fimbrial; pfam00419 685038013645 mannonate dehydratase; Region: uxuA; TIGR00695 685038013646 mannonate dehydratase; Provisional; Region: PRK03906 685038013647 D-mannonate oxidoreductase; Provisional; Region: PRK15037 685038013648 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 685038013649 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 685038013650 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 685038013651 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 685038013652 DNA-binding site [nucleotide binding]; DNA binding site 685038013653 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 685038013654 DNA replication/recombination/repair protein; Provisional; Region: iraD; PRK14128 685038013655 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 685038013656 dihydroxyacetone kinase, phosphotransfer subunit; Region: dha_pts; TIGR02364 685038013657 active pocket/dimerization site; other site 685038013658 active site 685038013659 phosphorylation site [posttranslational modification] 685038013660 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 685038013661 dimerization domain swap beta strand [polypeptide binding]; other site 685038013662 regulatory protein interface [polypeptide binding]; other site 685038013663 active site 685038013664 regulatory phosphorylation site [posttranslational modification]; other site 685038013665 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 685038013666 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 685038013667 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 685038013668 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 685038013669 dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005 685038013670 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 685038013671 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 685038013672 dimer interface [polypeptide binding]; other site 685038013673 active site 685038013674 metal binding site [ion binding]; metal-binding site 685038013675 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038013676 Major Facilitator Superfamily; Region: MFS_1; pfam07690 685038013677 putative substrate translocation pore; other site 685038013678 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 685038013679 BCCT family transporter; Region: BCCT; pfam02028 685038013680 glycerate kinase; Region: TIGR00045 685038013681 tartronate semialdehyde reductase; Provisional; Region: PRK15059 685038013682 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 685038013683 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 685038013684 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 685038013685 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 685038013686 glyoxylate carboligase; Provisional; Region: PRK11269 685038013687 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 685038013688 PYR/PP interface [polypeptide binding]; other site 685038013689 dimer interface [polypeptide binding]; other site 685038013690 TPP binding site [chemical binding]; other site 685038013691 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 685038013692 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 685038013693 TPP-binding site [chemical binding]; other site 685038013694 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 685038013695 GAF domain; Region: GAF; pfam01590 685038013696 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 685038013697 putative active site [active] 685038013698 heme pocket [chemical binding]; other site 685038013699 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685038013700 Walker A motif; other site 685038013701 ATP binding site [chemical binding]; other site 685038013702 Walker B motif; other site 685038013703 arginine finger; other site 685038013704 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 685038013705 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 685038013706 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 685038013707 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 685038013708 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 685038013709 cell density-dependent motility repressor; Provisional; Region: PRK10082 685038013710 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685038013711 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 685038013712 dimerization interface [polypeptide binding]; other site 685038013713 Isoaspartyl dipeptidase hydrolyzes the beta-L-isoaspartyl linkages in dipeptides, as part of the degradative pathway to eliminate proteins with beta-L-isoaspartyl peptide bonds, bonds whereby the beta-group of an aspartate forms the peptide link with the...; Region: Isoaspartyl-dipeptidase; cd01308 685038013714 isoaspartyl dipeptidase IadA; Region: isoAsp_dipep; TIGR01975 685038013715 dimer interface [polypeptide binding]; other site 685038013716 active site 685038013717 hypothetical protein; Provisional; Region: PRK10519 685038013718 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 685038013719 Nucleoside recognition; Region: Gate; pfam07670 685038013720 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 685038013721 RNA 2'-phosphotransferase, Tpt1 / KptA family; Region: PTS_2-RNA; cl19470 685038013722 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038013723 Major Facilitator Superfamily; Region: MFS_1; pfam07690 685038013724 putative substrate translocation pore; other site 685038013725 SdiA-regulated; Region: SdiA-regulated; cd09971 685038013726 putative active site [active] 685038013727 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 685038013728 CoA-substrate-specific enzyme activase, putative; Region: CoA_E_activ; TIGR00241 685038013729 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 685038013730 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 685038013731 Predicted membrane protein [Function unknown]; Region: COG2733 685038013732 Protein of unknown function (DUF445); Region: DUF445; pfam04286 685038013733 Uncharacterized conserved protein [Function unknown]; Region: COG5464 685038013734 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 685038013735 Uncharacterized conserved protein [Function unknown]; Region: COG1479 685038013736 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 685038013737 Uncharacterized conserved protein [Function unknown]; Region: COG3586 685038013738 endoribonuclease SymE; Provisional; Region: PRK13605 685038013739 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 685038013740 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 685038013741 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 685038013742 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 685038013743 HsdM N-terminal domain; Region: HsdM_N; pfam12161 685038013744 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 685038013745 Methyltransferase domain; Region: Methyltransf_26; pfam13659 685038013746 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 685038013747 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 685038013748 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 685038013749 ATP binding site [chemical binding]; other site 685038013750 putative Mg++ binding site [ion binding]; other site 685038013751 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 685038013752 Protein of unknown function DUF262; Region: DUF262; pfam03235 685038013753 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 685038013754 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 685038013755 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 685038013756 P-loop, Walker A motif; other site 685038013757 Base recognition motif; other site 685038013758 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 685038013759 Uncharacterized small protein [Function unknown]; Region: COG2879 685038013760 carbon starvation protein A; Provisional; Region: PRK15015 685038013761 Carbon starvation protein CstA; Region: CstA; pfam02554 685038013762 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 685038013763 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 685038013764 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 685038013765 dimer interface [polypeptide binding]; other site 685038013766 ligand binding site [chemical binding]; other site 685038013767 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 685038013768 dimerization interface [polypeptide binding]; other site 685038013769 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 685038013770 dimer interface [polypeptide binding]; other site 685038013771 putative CheW interface [polypeptide binding]; other site 685038013772 DctM-like transporters; Region: DctM; pfam06808 685038013773 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 685038013774 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 685038013775 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 685038013776 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 685038013777 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 685038013778 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 685038013779 DNA-binding site [nucleotide binding]; DNA binding site 685038013780 Transcriptional regulators [Transcription]; Region: GntR; COG1802 685038013781 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 685038013782 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 685038013783 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 685038013784 putative NAD(P) binding site [chemical binding]; other site 685038013785 catalytic Zn binding site [ion binding]; other site 685038013786 structural Zn binding site [ion binding]; other site 685038013787 phosphoglycerol transferase I; Provisional; Region: PRK03776 685038013788 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 685038013789 hypothetical protein; Provisional; Region: PRK11667 685038013790 DNA replication protein DnaC; Validated; Region: PRK07952 685038013791 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685038013792 Walker A motif; other site 685038013793 ATP binding site [chemical binding]; other site 685038013794 Walker B motif; other site 685038013795 primosomal protein DnaI; Provisional; Region: PRK02854 685038013796 hypothetical protein; Provisional; Region: PRK09917 685038013797 Uncharacterized conserved protein [Function unknown]; Region: COG2966 685038013798 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 685038013799 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 685038013800 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 685038013801 DNA binding residues [nucleotide binding] 685038013802 dimerization interface [polypeptide binding]; other site 685038013803 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 685038013804 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 685038013805 DNA binding residues [nucleotide binding] 685038013806 dimerization interface [polypeptide binding]; other site 685038013807 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 685038013808 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 685038013809 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 685038013810 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 685038013811 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 685038013812 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 685038013813 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685038013814 S-adenosylmethionine binding site [chemical binding]; other site 685038013815 DNA polymerase III, psi subunit [DNA replication, recombination, and repair]; Region: HolD; COG3050 685038013816 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 685038013817 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 685038013818 Coenzyme A binding pocket [chemical binding]; other site 685038013819 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 685038013820 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 685038013821 motif II; other site 685038013822 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 685038013823 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 685038013824 G1 box; other site 685038013825 putative GEF interaction site [polypeptide binding]; other site 685038013826 GTP/Mg2+ binding site [chemical binding]; other site 685038013827 Switch I region; other site 685038013828 G2 box; other site 685038013829 G3 box; other site 685038013830 Switch II region; other site 685038013831 G4 box; other site 685038013832 G5 box; other site 685038013833 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 685038013834 Elongation Factor G, domain II; Region: EFG_II; pfam14492 685038013835 periplasmic protein; Provisional; Region: PRK10568 685038013836 BON domain; Region: BON; pfam04972 685038013837 BON domain; Region: BON; pfam04972 685038013838 Small integral membrane protein [Function unknown]; Region: COG5487 685038013839 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 685038013840 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 685038013841 active site 685038013842 nucleophile elbow; other site 685038013843 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 685038013844 active site 685038013845 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 685038013846 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 685038013847 FeS/SAM binding site; other site 685038013848 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 685038013849 hypothetical protein; Provisional; Region: PRK10977 685038013850 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 685038013851 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 685038013852 intersubunit interface [polypeptide binding]; other site 685038013853 active site 685038013854 catalytic residue [active] 685038013855 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 685038013856 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 685038013857 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 685038013858 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 685038013859 phosphopentomutase; Provisional; Region: PRK05362 685038013860 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 685038013861 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09775 685038013862 HipA-like N-terminal domain; Region: HipA_N; pfam07805 685038013863 HipA-like C-terminal domain; Region: HipA_C; pfam07804 685038013864 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 685038013865 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 685038013866 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 685038013867 hypothetical protein; Provisional; Region: PRK11246 685038013868 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 685038013869 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 685038013870 motif II; other site 685038013871 DNA repair protein RadA; Region: sms; TIGR00416 685038013872 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 685038013873 Walker A motif/ATP binding site; other site 685038013874 ATP binding site [chemical binding]; other site 685038013875 Walker B motif; other site 685038013876 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 685038013877 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 685038013878 non-specific DNA binding site [nucleotide binding]; other site 685038013879 salt bridge; other site 685038013880 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 685038013881 sequence-specific DNA binding site [nucleotide binding]; other site 685038013882 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 685038013883 active site 685038013884 (T/H)XGH motif; other site 685038013885 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 685038013886 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 685038013887 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 685038013888 non-specific DNA binding site [nucleotide binding]; other site 685038013889 salt bridge; other site 685038013890 sequence-specific DNA binding site [nucleotide binding]; other site 685038013891 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 685038013892 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 685038013893 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 685038013894 ABC transporter; Region: ABC_tran_2; pfam12848 685038013895 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 685038013896 lytic murein transglycosylase; Provisional; Region: PRK11619 685038013897 Soluble lytic murein transglycosylase L domain; Region: SLT_L; pfam14718 685038013898 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 685038013899 N-acetyl-D-glucosamine binding site [chemical binding]; other site 685038013900 catalytic residue [active] 685038013901 Trp operon repressor; Provisional; Region: PRK01381 685038013902 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 685038013903 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 685038013904 catalytic core [active] 685038013905 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 685038013906 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 685038013907 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 685038013908 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 685038013909 hypothetical protein; Provisional; Region: PRK10756 685038013910 DNA-binding response regulator CreB; Provisional; Region: PRK11083 685038013911 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685038013912 active site 685038013913 phosphorylation site [posttranslational modification] 685038013914 intermolecular recognition site; other site 685038013915 dimerization interface [polypeptide binding]; other site 685038013916 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 685038013917 DNA binding site [nucleotide binding] 685038013918 sensory histidine kinase CreC; Provisional; Region: PRK11100 685038013919 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 685038013920 dimerization interface [polypeptide binding]; other site 685038013921 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 685038013922 dimer interface [polypeptide binding]; other site 685038013923 phosphorylation site [posttranslational modification] 685038013924 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685038013925 ATP binding site [chemical binding]; other site 685038013926 Mg2+ binding site [ion binding]; other site 685038013927 G-X-G motif; other site 685038013928 Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452 685038013929 two-component response regulator; Provisional; Region: PRK11173 685038013930 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685038013931 active site 685038013932 phosphorylation site [posttranslational modification] 685038013933 intermolecular recognition site; other site 685038013934 dimerization interface [polypeptide binding]; other site 685038013935 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 685038013936 DNA binding site [nucleotide binding] 685038013937 putative RNA methyltransferase; Provisional; Region: PRK10433 685038013938 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050 685038013939 transposase fragments; sequence similarity to: YP_002330505.1 predicted transposase [Escherichia coli O127:H6 str. E2348/69] 685038013940 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 685038013941 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 685038013942 homodimer interface [polypeptide binding]; other site 685038013943 active site 685038013944 TDP-binding site; other site 685038013945 acceptor substrate-binding pocket; other site 685038013946 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 685038013947 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 685038013948 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685038013949 Walker A/P-loop; other site 685038013950 ATP binding site [chemical binding]; other site 685038013951 Q-loop/lid; other site 685038013952 ABC transporter signature motif; other site 685038013953 Walker B; other site 685038013954 D-loop; other site 685038013955 H-loop/switch region; other site 685038013956 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 685038013957 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 685038013958 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685038013959 Walker A/P-loop; other site 685038013960 ATP binding site [chemical binding]; other site 685038013961 Q-loop/lid; other site 685038013962 ABC transporter signature motif; other site 685038013963 Walker B; other site 685038013964 D-loop; other site 685038013965 H-loop/switch region; other site 685038013966 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 685038013967 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 685038013968 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 685038013969 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 685038013970 outer membrane receptor FepA; Provisional; Region: PRK13528 685038013971 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 685038013972 N-terminal plug; other site 685038013973 ligand-binding site [chemical binding]; other site 685038013974 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 685038013975 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 685038013976 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 685038013977 Sequence similarity to: YP_002401113.1 Colicin V secretion/processing ATP-binding protein CvaB [Escherichia coli S88] 685038013978 Sequence similarity to: ACO91612.1 colicin B activity protein [Escherichia coli] (fragment) 685038013979 Sequence similarity to: YP_002527508.1 colicin B immunity protein Cbi [Escherichia coli] & YP_001481274.1 Cbi [Escherichia coli APEC O1] 685038013980 Colicin M; Region: Colicin_M; pfam14859 685038013981 YebF-like protein; Region: YebF; pfam13995 685038013982 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 685038013983 active site 685038013984 catalytic residues [active] 685038013985 DNA binding site [nucleotide binding] 685038013986 Int/Topo IB signature motif; other site 685038013987 biotin/lipoate protein ligase; Provisional; Region: PTZ00276 685038013988 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 685038013989 Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; pfam10137 685038013990 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 685038013991 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 685038013992 oligomeric interface; other site 685038013993 putative active site [active] 685038013994 homodimer interface [polypeptide binding]; other site 685038013995 AAA domain; Region: AAA_13; pfam13166 685038013996 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685038013997 Walker B; other site 685038013998 D-loop; other site 685038013999 H-loop/switch region; other site 685038014000 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685038014001 Walker A/P-loop; other site 685038014002 ATP binding site [chemical binding]; other site 685038014003 FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cl15270 685038014004 putative kissing complex interaction region; other site 685038014005 putative RNA binding sites [nucleotide binding]; other site 685038014006 Predicted permease; Region: DUF318; cl17795 685038014007 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 685038014008 dimerization interface [polypeptide binding]; other site 685038014009 putative DNA binding site [nucleotide binding]; other site 685038014010 putative Zn2+ binding site [ion binding]; other site 685038014011 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 685038014012 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 685038014013 catalytic triad [active] 685038014014 conserved cis-peptide bond; other site 685038014015 EamA-like transporter family; Region: EamA; pfam00892 685038014016 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 685038014017 EamA-like transporter family; Region: EamA; pfam00892 685038014018 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038014019 Major Facilitator Superfamily; Region: MFS_1; pfam07690 685038014020 putative substrate translocation pore; other site 685038014021 tetracycline repressor protein TetR; Provisional; Region: PRK13756 685038014022 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685038014023 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 685038014024 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 685038014025 Sequence similarity to: YP_001338843.1 hypothetical protein KPN_pKPN5p08233 [Klebsiella pneumoniae subsp. pneumoniae MGH 78578] 685038014026 chloramphenicol acetyltransferase; Provisional; Region: PRK13757 685038014027 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 685038014028 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 685038014029 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 685038014030 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 685038014031 Divergent AAA domain; Region: AAA_4; pfam04326 685038014032 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 685038014033 Transposase; Region: HTH_Tnp_1; cl17663 685038014034 Integrase core domain; Region: rve; pfam00665 685038014035 beta-lactamase TEM; Provisional; Region: PRK15442 685038014036 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 685038014037 Resolvase, N terminal domain; Region: Resolvase; pfam00239 685038014038 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393 685038014039 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 685038014040 Transposase; Region: HTH_Tnp_1; cl17663 685038014041 Integrase core domain; Region: rve; pfam00665 685038014042 Sequence similarity to: NP_044309.1 replication protein A [Plasmid RSF1010]; fragment missing N-terminus 685038014043 Replication initiator protein A; Region: RPA; cl19398 685038014044 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 685038014045 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 685038014046 substrate binding pocket [chemical binding]; other site 685038014047 dimer interface [polypeptide binding]; other site 685038014048 inhibitor binding site; inhibition site 685038014049 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 685038014050 Phosphotransferase enzyme family; Region: APH; pfam01636 685038014051 active site 685038014052 ATP binding site [chemical binding]; other site 685038014053 antibiotic binding site [chemical binding]; other site 685038014054 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; pfam04655 685038014055 integrase/recombinase; Provisional; Region: PRK15417 685038014056 IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193 685038014057 Int/Topo IB signature motif; other site 685038014058 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 685038014059 folate binding site [chemical binding]; other site 685038014060 NADP+ binding site [chemical binding]; other site 685038014061 aminoglycoside resistance protein; Provisional; Region: PRK13746 685038014062 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 685038014063 active site 685038014064 NTP binding site [chemical binding]; other site 685038014065 metal binding triad [ion binding]; metal-binding site 685038014066 antibiotic binding site [chemical binding]; other site 685038014067 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 685038014068 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 685038014069 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 685038014070 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 685038014071 substrate binding pocket [chemical binding]; other site 685038014072 dimer interface [polypeptide binding]; other site 685038014073 inhibitor binding site; inhibition site 685038014074 transposase/IS protein; Provisional; Region: PRK09183 685038014075 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685038014076 Walker A motif; other site 685038014077 ATP binding site [chemical binding]; other site 685038014078 Walker B motif; other site 685038014079 arginine finger; other site 685038014080 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 685038014081 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 685038014082 Integrase core domain; Region: rve; pfam00665 685038014083 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 685038014084 Bacterial TniB protein; Region: TniB; pfam05621 685038014085 Sequence similarity to: YP_001355220.1 hypothetical protein mma_3530 [Janthinobacterium sp. Marseille]; putative diguanylate cyclase 685038014086 Beta-lactamase; Region: Beta-lactamase; pfam00144 685038014087 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685038014088 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685038014089 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 685038014090 Putative lysophospholipase; Region: Hydrolase_4; cl19140 685038014091 TAP-like protein; Region: Abhydrolase_4; pfam08386 685038014092 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152 685038014093 Phosphotransferase enzyme family; Region: APH; pfam01636 685038014094 putative active site [active] 685038014095 putative substrate binding site [chemical binding]; other site 685038014096 ATP binding site [chemical binding]; other site 685038014097 Bacterial TniB protein; Region: TniB; pfam05621 685038014098 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 685038014099 Putative transposase; Region: Y2_Tnp; pfam04986 685038014100 Integrase core domain; Region: rve; pfam00665 685038014101 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 685038014102 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 685038014103 putative mercury resistance protein; Provisional; Region: PRK13747 685038014104 transcriptional regulator MerD; Provisional; Region: PRK13749 685038014105 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 685038014106 DNA binding residues [nucleotide binding] 685038014107 putative mercuric reductase; Provisional; Region: PRK13748 685038014108 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 685038014109 metal-binding site [ion binding] 685038014110 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 685038014111 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 685038014112 putative mercury transport protein MerC; Provisional; Region: PRK13755 685038014113 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 685038014114 metal-binding site [ion binding] 685038014115 putative mercuric transport protein; Provisional; Region: PRK13751 685038014116 putative transcriptional regulator MerR; Provisional; Region: PRK13752 685038014117 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 685038014118 DNA binding residues [nucleotide binding] 685038014119 dimer interface [polypeptide binding]; other site 685038014120 mercury binding site [ion binding]; other site 685038014121 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 685038014122 PemK-like protein; Region: PemK; cl00995 685038014123 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 685038014124 CAAX protease self-immunity; Region: Abi; pfam02517 685038014125 Sequence similarity to: YP_001739890.1 replication initiation protein repA4 [Escherichia coli SMS-3-5]; internal stop codon 685038014126 replication protein; Provisional; Region: PRK13750 685038014127 IncFII RepA protein family; Region: IncFII_repA; cl11495 685038014128 replication protein; Provisional; Region: PRK13702 685038014129 Hok/gef family; Region: HOK_GEF; pfam01848 685038014130 Sequence similarity to: YP_001919156.1 staphylococcal nuclease homolog [Escherichia coli 53638] 685038014131 Sequence similarity to: YP_313453.1 hypothetical protein SSON_P199 [Shigella sonnei Ss046]; internal stop codon 685038014132 conjugal transfer fertility inhibition protein FinO; Provisional; Region: PRK13754 685038014133 Fertility inhibition protein N terminal; Region: FinO_N; pfam12602 685038014134 FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cd00236 685038014135 putative kissing complex interaction region; other site 685038014136 putative RNA binding sites [nucleotide binding]; other site 685038014137 Putative lysophospholipase; Region: Hydrolase_4; cl19140 685038014138 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 685038014139 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 685038014140 conjugal transfer pilus acetylation protein TraX; Provisional; Region: PRK13706 685038014141 conjugal transfer nickase/helicase TraI; Provisional; Region: PRK13709 685038014142 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 685038014143 AAA domain; Region: AAA_30; pfam13604 685038014144 DNA helicase TraI; Region: TraI; pfam07057 685038014145 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 685038014146 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 685038014147 oligomeric interface; other site 685038014148 putative active site [active] 685038014149 homodimer interface [polypeptide binding]; other site 685038014150 conjugal transfer protein TraD; Provisional; Region: PRK13700 685038014151 F sex factor protein N terminal; Region: TraD_N; pfam12615 685038014152 Bacterial conjugation protein TrwB, ATP binding domain. TrwB is a homohexamer encoded by conjugative plasmids in Gram-negative bacteria. TrwB also has an all alpha domain which has been hypothesized to be responsible for DNA binding. TrwB is a component...; Region: TrwB; cd01127 685038014153 multimer interface [polypeptide binding]; other site 685038014154 Walker A motif; other site 685038014155 ATP binding site [chemical binding]; other site 685038014156 Walker B motif; other site 685038014157 conjugal transfer surface exclusion protein TraT; Provisional; Region: PRK13731 685038014158 Plasmid conjugative transfer entry exclusion protein TraS; Region: TraS; pfam10624 685038014159 conjugal transfer mating pair stabilization protein TraG; Provisional; Region: PRK13735 685038014160 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 685038014161 conjugal transfer pilus assembly protein TraB; Provisional; Region: PRK13729 685038014162 Extensin-like region; Region: Extensin_2; pfam04554 685038014163 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 685038014164 Conjugative relaxosome accessory transposon protein; Region: TraH; cl05580 685038014165 conjugal transfer protein TraK; Provisional; Region: PRK13736 685038014166 conjugal transfer pilus assembly protein TraE; Provisional; Region: PRK13726 685038014167 conjugal transfer pilus assembly protein TraL; Provisional; Region: PRK13707 685038014168 conjugal transfer pilin subunit TraA; Provisional; Region: PRK13734 685038014169 conjugal transfer protein TraY; Provisional; Region: PRK13740 685038014170 TraY domain; Region: TraY; pfam05509 685038014171 TraY domain; Region: TraY; pfam05509 685038014172 conjugal transfer transcriptional regulator TraJ; Provisional; Region: PRK13719 685038014173 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 685038014174 dimerization interface [polypeptide binding]; other site 685038014175 DNA binding residues [nucleotide binding] 685038014176 TraM protein, DNA-binding; Region: Tra_M; pfam05261 685038014177 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 685038014178 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 685038014179 N-acetyl-D-glucosamine binding site [chemical binding]; other site 685038014180 catalytic residue [active] 685038014181 Domain of unknown function (DUF932); Region: DUF932; pfam06067 685038014182 modulator of post-segregation killing protein; Provisional; Region: PRK13720 685038014183 plasmid SOS inhibition protein A; Provisional; Region: PRK13704 685038014184 plasmid SOS inhibition protein B; Provisional; Region: psiB; PRK13701 685038014185 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 685038014186 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 685038014187 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 685038014188 dimer interface [polypeptide binding]; other site 685038014189 ssDNA binding site [nucleotide binding]; other site 685038014190 tetramer (dimer of dimers) interface [polypeptide binding]; other site 685038014191 Protein of unknown function (DUF1472); Region: DUF1472; pfam07339 685038014192 plasmid-partitioning protein; Provisional; Region: PRK13698 685038014193 ParB-like nuclease domain; Region: ParB; smart00470 685038014194 plasmid-partitioning protein SopA; Provisional; Region: PRK13705 685038014195 MerR family regulatory protein; Region: MerR; pfam00376 685038014196 DNA binding residues [nucleotide binding] 685038014197 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 685038014198 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 685038014199 P-loop; other site 685038014200 Magnesium ion binding site [ion binding]; other site 685038014201 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 685038014202 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 685038014203 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 685038014204 N-terminal plug; other site 685038014205 ligand-binding site [chemical binding]; other site 685038014206 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 685038014207 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 685038014208 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 685038014209 IucA / IucC family; Region: IucA_IucC; pfam04183 685038014210 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 685038014211 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 685038014212 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 685038014213 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 685038014214 IucA / IucC family; Region: IucA_IucC; pfam04183 685038014215 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 685038014216 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685038014217 putative substrate translocation pore; other site 685038014218 Major Facilitator Superfamily; Region: MFS_1; pfam07690 685038014219 chromosome condensation membrane protein; Provisional; Region: PRK14196 685038014220 Telomerase activating protein Est1; Region: EST1; pfam10374 685038014221 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 685038014222 ABC-ATPase subunit interface; other site 685038014223 dimer interface [polypeptide binding]; other site 685038014224 putative PBP binding regions; other site 685038014225 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 685038014226 ABC-ATPase subunit interface; other site 685038014227 dimer interface [polypeptide binding]; other site 685038014228 putative PBP binding regions; other site 685038014229 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 685038014230 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 685038014231 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 685038014232 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 685038014233 metal binding site [ion binding]; metal-binding site 685038014234 Sequence similarity to IS1 transposase fragments 685038014235 Sequence similarity to: NP_052473.1 hypothetical protein ColIb-P9_p027 [Plasmid ColIb-P9]; fragment of plasmid stability protein ParB 685038014236 Sequence similarity to: YP_002418712.1 DNA polymerase type-Y, UV protection protein impB [Escherichia coli]; fragment of DNA polymerase V subunit UmuC 685038014237 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 685038014238 Homeodomain-like domain; Region: HTH_23; pfam13384 685038014239 Transposase family tnp2; Region: Transposase_21; pfam02992 685038014240 Initiator Replication protein; Region: Rep_3; pfam01051 685038014241 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 685038014242 active site 685038014243 catalytic residues [active] 685038014244 DNA binding site [nucleotide binding] 685038014245 Int/Topo IB signature motif; other site 685038014246 antimicrobial resistance protein Mig-14; Provisional; Region: PRK15312 685038014247 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685038014248 Male sterility protein; Region: NAD_binding_4; pfam07993 685038014249 NAD(P) binding site [chemical binding]; other site 685038014250 active site 685038014251 outer membrane protease; Reviewed; Region: PRK10993 685038014252 Sequence similarity to: YP_444075.1 transposase [Escherichia coli]; fragments 685038014253 putative transposase OrfB; Reviewed; Region: PHA02517 685038014254 HTH-like domain; Region: HTH_21; pfam13276 685038014255 Integrase core domain; Region: rve; pfam00665 685038014256 Integrase core domain; Region: rve_3; pfam13683 685038014257 Sequence similarity to: NP_835957.1 IS911 orfA [Shigella flexneri 2a str. 2457T] 685038014258 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 685038014259 Winged helix-turn helix; Region: HTH_29; pfam13551 685038014260 Helix-turn-helix domain; Region: HTH_28; pfam13518 685038014261 Homeodomain-like domain; Region: HTH_32; pfam13565 685038014262 Integrase core domain; Region: rve; pfam00665 685038014263 Sequence similarity to: NP_839078.2 insertion element IS2 transposase InsD [Shigella flexneri 2a str. 2457T]; fragment 685038014264 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 685038014265 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 685038014266 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 685038014267 Sequence similarity to: NP_928533.1 transposase IS100 [Photorhabdus luminescens subsp. laumondii TTO1]; fragments 685038014268 IS2 transposase TnpB; Reviewed; Region: PRK09409 685038014269 HTH-like domain; Region: HTH_21; pfam13276 685038014270 Integrase core domain; Region: rve; pfam00665 685038014271 Integrase core domain; Region: rve_3; pfam13683 685038014272 Transposase; Region: HTH_Tnp_1; cl17663 685038014273 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 685038014274 Sequence similarity to: NP_753473.1 Bor protein homolog from lambdoid prophage DLP12 precursor [Escherichia coli CFT073] 685038014275 Sequence similarity to: YP_410579.1 hypothetical protein SBO_4335 [Shigella boydii Sb227]; fragment 685038014276 Sequence similarity to: YP_540317.1 putative Rz endopeptidase from lambdoid prophage DLP12 [Escherichia coli UTI89]; fragments